Paolo Bettica

HDAC inhibitors tune miRNAs in extracellular vesicles of dystrophic muscle-resident mesenchymal cells.

Authors:

Martina Sandonà Silvia Consalvi Luca Tucciarone Marco De Bardi Manuel Scimeca Daniela Francesca Angelini Valentina Buffa Adele D'Amico Enrico Silvio Bertini Sara Cazzaniga Paolo Bettica Marina Bouché Antonella Bongiovanni Pier Lorenzo Puri Valentina Saccone

EMBO Rep 2020 Sep 5;21(9):e50863. Epub 2020 Aug 5.

Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Fondazione Santa Lucia, Rome, Italy.

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September 2020

Real-world evidence of riluzole effectiveness in treating amyotrophic lateral sclerosis.

Authors:

Jinsy A Andrews Carlayne E Jackson Terry D Heiman-Patterson Paolo Bettica Benjamin Rix Brooks Erik P Pioro

Amyotroph Lateral Scler Frontotemporal Degener 2020 11 23;21(7-8):509-518. Epub 2020 Jun 23.

Neuromuscular Centre, Neurological Institute, Cleveland Clinic, Cleveland, OH, USA.

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November 2020

Safety and efficacy of the maximum tolerated dose of givinostat in polycythemia vera: a two-part Phase Ib/II study.

Leukemia 2020 08 11;34(8):2234-2237. Epub 2020 Feb 11.

Clinical R&D Department, Italfarmaco S.p.A., Cinisello Balsamo, Italy.

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August 2020

Riluzole Oral Suspension: Bioavailability Following Percutaneous Gastrostomy Tube-modeled Administration Versus Direct Oral Administration.

Authors:

Benjamin Rix Brooks Paolo Bettica Sara Cazzaniga

Clin Ther 2019 12 18;41(12):2490-2499. Epub 2019 Oct 18.

Italfarmaco SpA, Milan, Italy.

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December 2019

Reduced serotonin synthesis and regional cerebral blood flow after anxiolytic treatment of social anxiety disorder.

Authors:

Andreas Frick Fredrik Åhs Lieuwe Appel My Jonasson Kurt Wahlstedt Massimo Bani Emilio Merlo Pich Paolo Bettica Bengt Långström Mark Lubberink Mats Fredrikson Tomas Furmark

Eur Neuropsychopharmacol 2016 11 15;26(11):1775-1783. Epub 2016 Sep 15.

Department of Psychology, Uppsala University, Uppsala, Sweden.

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November 2016

Histological effects of givinostat in boys with Duchenne muscular dystrophy.

Neuromuscul Disord 2016 10 11;26(10):643-649. Epub 2016 Jul 11.

Department of Paediatric Neurology, Catholic University, Rome, Italy.

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October 2016

Amygdala-frontal couplings characterizing SSRI and placebo response in social anxiety disorder.

Authors:

Vanda Faria Fredrik Ahs Lieuwe Appel Clas Linnman Massimo Bani Paolo Bettica Emilio Merlo Pich Kurt Wahlstedt Mats Fredrikson Tomas Furmark

Int J Neuropsychopharmacol 2014 Aug 26;17(8):1149-57. Epub 2014 Mar 26.

Department of Psychology,Uppsala University,Uppsala,Sweden.

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August 2014

Anxiolytic effects of vestipitant in a sub-group of healthy volunteers known to be sensitive to CO2 challenge.

Authors:

Stefano Zanone Poma Emilio Merlo-Pich Paolo Bettica Massimo Bani Paolo Fina Luigi Ziviani Stefano Milleri

J Psychopharmacol 2014 May 9;28(5):491-7. Epub 2013 Oct 9.

1Department of Neuroscience, University of Padova, Italy.

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May 2014

Preclinical studies in the mdx mouse model of duchenne muscular dystrophy with the histone deacetylase inhibitor givinostat.

Authors:

Silvia Consalvi Chiara Mozzetta Paolo Bettica Massimiliano Germani Francesco Fiorentini Francesca Del Bene Maurizio Rocchetti Flavio Leoni Valmen Monzani Paolo Mascagni Pier Lorenzo Puri Valentina Saccone

Mol Med 2013 May 20;19:79-87. Epub 2013 May 20.

IRCCS Fondazione Santa Lucia, Rome, Italy.

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May 2013

Full central neurokinin-1 receptor blockade is required for efficacy in depression: evidence from orvepitant clinical studies.

Authors:

Emiliangelo Ratti Paolo Bettica Robert Alexander Graeme Archer David Carpenter Gary Evoniuk Roberto Gomeni Erica Lawson Monica Lopez Helen Millns Eugenii A Rabiner David Trist Michael Trower Stefano Zamuner Ranga Krishnan Maurizio Fava

J Psychopharmacol 2013 May 28;27(5):424-34. Epub 2013 Mar 28.

Neurosciences Center for Excellence in Drug Discovery, GlaxoSmithKline, Verona, Italy.

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May 2013

The orexin antagonist SB-649868 promotes and maintains sleep in men with primary insomnia.

Authors:

Paolo Bettica Lisa Squassante Stefano Zamuner Gianluca Nucci Heidi Danker-Hopfe Emiliangelo Ratti

Sleep 2012 Aug 1;35(8):1097-104. Epub 2012 Aug 1.

Neuroscience CEDD Discovery Medicine, GlaxoSmithKline, Verona, Italy.

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August 2012

Amygdala subregions tied to SSRI and placebo response in patients with social anxiety disorder.

Authors:

Vanda Faria Lieuwe Appel Fredrik Åhs Clas Linnman Anna Pissiota Örjan Frans Massimo Bani Paolo Bettica Emilio M Pich Eva Jacobsson Kurt Wahlstedt Mats Fredrikson Tomas Furmark

Neuropsychopharmacology 2012 Sep 23;37(10):2222-32. Epub 2012 May 23.

Department of Psychology, Uppsala University, Uppsala, Sweden.

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September 2012

Differential effects of a dual orexin receptor antagonist (SB-649868) and zolpidem on sleep initiation and consolidation, SWS, REM sleep, and EEG power spectra in a model of situational insomnia.

Authors:

Paolo Bettica Lisa Squassante John A Groeger Brian Gennery Raphaelle Winsky-Sommerer Derk-Jan Dijk

Neuropsychopharmacology 2012 Apr 11;37(5):1224-33. Epub 2012 Jan 11.

Neuroscience CEDD Discovery Medicine, GlaxoSmithKline, Verona, Italy.

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April 2012

Results from 2 randomized, double-blind, placebo-controlled studies of the novel NK1 receptor antagonist casopitant in patients with major depressive disorder.

Authors:

Emiliangelo Ratti Kevin Bellew Paolo Bettica Heather Bryson Stefano Zamuner Graeme Archer Lisa Squassante Alan Bye David Trist K Ranga Krishnan Sofia Fernandes

J Clin Psychopharmacol 2011 Dec;31(6):727-33

GlaxoSmithKline, Neurosciences Discovery Medicine, King of Prussia, PA, USA.

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December 2011

Phase I studies on the safety, tolerability, pharmacokinetics and pharmacodynamics of SB-649868, a novel dual orexin receptor antagonist.

Authors:

Paolo Bettica Gianluca Nucci Caroline Pyke Lisa Squassante Stefano Zamuner Emiliangelo Ratti Roberto Gomeni Robert Alexander

J Psychopharmacol 2012 Aug 5;26(8):1058-70. Epub 2011 Jul 5.

Neurosciences Center for Excellence in Drug Discovery, GlaxoSmithKline, Verona, Italy.

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August 2012

A selective neurokinin-1 receptor antagonist in chronic PTSD: a randomized, double-blind, placebo-controlled, proof-of-concept trial.

Authors:

Sanjay J Mathew Meena Vythilingam James W Murrough Carlos A Zarate Adriana Feder David A Luckenbaugh Becky Kinkead Michael K Parides David G Trist Massimo S Bani Paolo U Bettica Emiliangelo M Ratti Dennis S Charney

Eur Neuropsychopharmacol 2011 Mar 30;21(3):221-9. Epub 2010 Dec 30.

Mood & Anxiety Disorders Program, Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA.

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March 2011

Disposition and metabolism of [14C]SB-649868, an orexin 1 and 2 receptor antagonist, in humans.

Authors:

Cecilia Renzulli Mike Nash Mark Wright Steven Thomas Stefano Zamuner Mario Pellegatti Paolo Bettica Gary Boyle

Drug Metab Dispos 2011 Feb 2;39(2):215-27. Epub 2010 Nov 2.

Department of Drug Metabolism and Pharmacokinetics, GlaxoSmithKline Research and Development, Verona, Italy.

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February 2011

Effects of 7.5% CO2 challenge in generalized anxiety disorder.

Authors:

Kate Seddon Kelly Morris Jayne Bailey John Potokar Ann Rich Sue Wilson Paolo Bettica David J Nutt

J Psychopharmacol 2011 Jan 16;25(1):43-51. Epub 2010 Mar 16.

University of Bristol, Psychopharmacology Unit, Bristol, UK.

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January 2011

A link between serotonin-related gene polymorphisms, amygdala activity, and placebo-induced relief from social anxiety.

Authors:

Tomas Furmark Lieuwe Appel Susanne Henningsson Fredrik Ahs Vanda Faria Clas Linnman Anna Pissiota Orjan Frans Massimo Bani Paolo Bettica Emilio Merlo Pich Eva Jacobsson Kurt Wahlstedt Lars Oreland Bengt Långström Elias Eriksson Mats Fredrikson

J Neurosci 2008 Dec;28(49):13066-74

Department of Psychology, Uppsala University, Uppsala, Sweden.

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December 2008

A link between serotonin-related gene polymorphisms, amygdala activity, and placebo-induced relief from social anxiety.

Authors:

Tomas Furmark Lieuwe Appel Susanne Henningsson Fredrik Ahs Vanda Faria Clas Linnman Anna Pissiota Orjan Frans Massimo Bani Paolo Bettica Emilio Merlo Pich Eva Jacobsson Kurt Wahlstedt Lars Oreland Bengt Långström Elias Eriksson Mats Fredrikson

J Neurosci 2008 Dec;28(49):13066-74

Department of Psychology, Uppsala University, Uppsala, Sweden.

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December 2008

Evidence for increased bone resorption in patients with progressive knee osteoarthritis: longitudinal results from the Chingford study.

Authors:

Paolo Bettica Gary Cline Deborah J Hart Joan Meyer Tim D Spector

Arthritis Rheum 2002 Dec;46(12):3178-84

Procter & Gamble Pharmaceuticals, Staines, UK.

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December 2002

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