Publications by authors named "Paola Infante"

38Publications

The SHH/GLI signaling pathway: a therapeutic target for medulloblastoma.

Expert Opin Ther Targets 2020 Sep 29:1-23. Epub 2020 Sep 29.

Department of Molecular Medicine, University of Rome La Sapienza , 00161, Rome, Italy.

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http://dx.doi.org/10.1080/14728222.2020.1823967DOI Listing
September 2020

DUBs Activating the Hedgehog Signaling Pathway: A Promising Therapeutic Target in Cancer.

Cancers (Basel) 2020 Jun 10;12(6). Epub 2020 Jun 10.

Department of Molecular Medicine, Sapienza University, Viale Regina Elena 291, 00161 Rome, Italy.

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http://dx.doi.org/10.3390/cancers12061518DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7352588PMC
June 2020

Hedgehog signaling pathway inhibitors: an updated patent review (2015-present).

Expert Opin Ther Pat 2020 Apr 19;30(4):235-250. Epub 2020 Feb 19.

Department of Biotechnology, Chemistry and Pharmacy, Department of Excellence 2018-2022, University of Siena, Siena, Italy.

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http://dx.doi.org/10.1080/13543776.2020.1730327DOI Listing
April 2020

Phenformin Inhibits Hedgehog-Dependent Tumor Growth through a Complex I-Independent Redox/Corepressor Module.

Cell Rep 2020 02;30(6):1735-1752.e7

Department of Molecular Medicine, Sapienza University of Rome, 00161 Rome, Italy; Istituto Pasteur, Fondazione Cenci-Bolognetti, Sapienza University of Rome, 00161 Rome, Italy; International Polyamines Foundation-ONLUS, 00159 Rome, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2020.01.024DOI Listing
February 2020

Discovery, characterization and potential roles of a novel NF-YAx splice variant in human neuroblastoma.

J Exp Clin Cancer Res 2019 Dec 5;38(1):482. Epub 2019 Dec 5.

Department of Applied Clinical and Biotechnological Sciences, University of L'Aquila, Via Vetoio, Coppito 2, 67100, L'Aquila, Italy.

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http://dx.doi.org/10.1186/s13046-019-1481-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6896337PMC
December 2019

Natural Products Inspired Modulators of Cancer Stem Cells-specific Signaling Pathways Notch and Hedgehog.

Curr Pharm Des 2018 ;24(36):4251-4269

Department of Biotechnology, Chemistry and Pharmacy, "Department of Excellence 2018-2022", University of Siena, via Aldo Moro 2, 53100 Siena, Italy.

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http://dx.doi.org/10.2174/1381612825666190111124822DOI Listing
October 2019

Current trends in Hedgehog signaling pathway inhibition by small molecules.

Bioorg Med Chem Lett 2018 10 27;28(19):3131-3140. Epub 2018 Aug 27.

Center for Life Nano Science@Sapienza, Istituto Italiano di Tecnologia, Viale Regina Elena 291, 00161 Rome, Italy.

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http://dx.doi.org/10.1016/j.bmcl.2018.08.033DOI Listing
October 2018

Synergistic inhibition of the Hedgehog pathway by newly designed Smo and Gli antagonists bearing the isoflavone scaffold.

Eur J Med Chem 2018 Aug 9;156:554-562. Epub 2018 Jul 9.

Center for Life Nano Science@Sapienza, Istituto Italiano di Tecnologia, Viale Regina Elena 291, 00161 Rome, Italy.

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http://dx.doi.org/10.1016/j.ejmech.2018.07.017DOI Listing
August 2018

Polymeric glabrescione B nanocapsules for passive targeting of Hedgehog-dependent tumor therapy in vitro.

Nanomedicine (Lond) 2017 Apr 21;12(7):711-728. Epub 2017 Mar 21.

Institute of Pharmaceutical Science, Faculty of Life Sciences & Medicine, King's College London, Franklin-Wilkins Building, London, SE1 9NH, UK.

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http://dx.doi.org/10.2217/nnm-2016-0388DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5986025PMC
April 2017

Insights into Gli Factors Ubiquitylation Methods.

Methods Mol Biol 2015 ;1322:131-46

Center for Life NanoScience at Sapienza, Istituto Italiano di Tecnologia, 00161, Rome, Italy.

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http://dx.doi.org/10.1007/978-1-4939-2772-2_12DOI Listing
April 2016

Targeting GLI factors to inhibit the Hedgehog pathway.

Trends Pharmacol Sci 2015 Aug 10;36(8):547-58. Epub 2015 Jun 10.

Center for Life Nano Science@Sapienza, Istituto Italiano di Tecnologia, 00161 Rome, Italy; Department of Molecular Medicine, "La Sapienza" University, 00161 Rome, Italy; Pasteur Institute/Cenci Bolognetti Foundation, Rome, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.tips.2015.05.006DOI Listing
August 2015

Click Reaction as a Tool to Combine Pharmacophores: The Case of Vismodegib.

Chempluschem 2015 Jun 27;80(6):938-943. Epub 2015 Feb 27.

Dipartimento di Chimica, Università degli Studi di Milano, Via Golgi 19, 20133 Milano (Italy), Fax: (+39) 02-50314078.

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http://dx.doi.org/10.1002/cplu.201402435DOI Listing
June 2015

Yin-Yang strands of PCAF/Hedgehog axis in cancer control.

Trends Mol Med 2014 Aug 4;20(8):416-8. Epub 2014 Jun 4.

Department of Molecular Medicine, "La Sapienza" University, 00161 Rome, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.molmed.2014.05.003DOI Listing
August 2014

Control of stem cells and cancer stem cells by Hedgehog signaling: pharmacologic clues from pathway dissection.

Biochem Pharmacol 2013 Mar 10;85(5):623-628. Epub 2012 Nov 10.

Center for Life NanoScience@LaSapienza, Istituto Italiano di Tecnologia, Italy; Department of Molecular Medicine, Sapienza University, 00161 Rome, Italy; Neuromed Institute, 86077 Pozzilli, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.bcp.2012.11.001DOI Listing
March 2013

Protected from the inside: endogenous histone deacetylase inhibitors and the road to cancer.

Biochim Biophys Acta 2011 Apr 26;1815(2):241-52. Epub 2011 Jan 26.

Department of Molecular Medicine, Sapienza University, Rome, Italy.

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http://dx.doi.org/10.1016/j.bbcan.2011.01.002DOI Listing
April 2011