Paola Guglielmelli

Paola Guglielmelli

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Paola Guglielmelli

Paola Guglielmelli

Publications by authors named "Paola Guglielmelli"

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Myelodysplasia as assessed by multiparameter flow cytometry refines prognostic stratification provided by genotypic risk in systemic mastocytosis.

Am J Hematol 2019 Aug 21;94(8):845-852. Epub 2019 May 21.

CRIMM, Centro di Ricerca e Innovazione per le Malattie Mieloproliferative, Azienda Ospedaliera Universitaria Careggi, Dipartimento di Medicina Sperimentale e Clinica, Denothe Excellence Center, Università degli Studi, Firenze, Italy.

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http://dx.doi.org/10.1002/ajh.25506DOI Listing
August 2019

Spectrum of mutations in primary myelofibrosis: prognostic impact of the p.G646Wfs*12 mutation.

Blood 2019 Jun 10;133(26):2802-2808. Epub 2019 May 10.

Centro di Ricerca e Innovazione per le Malattie Mieloproliferative (CRIMM), Dipartimento di Medicina Sperimentale e Clinica, Azienda Ospedaliera Universitaria Careggi, and.

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http://dx.doi.org/10.1182/blood.2018879536DOI Listing
June 2019

Nano-GLADIATOR: real-time detection of copy number alterations from nanopore sequencing data.

Bioinformatics 2019 Apr 5. Epub 2019 Apr 5.

Department of Experimental and Clinical Medicine, CRIMM, Center Research and Innovation of Myeloproliferative Neoplasms, Azienda Ospedaliera Universitaria Careggi, University of Florence, Florence, Italy.

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http://dx.doi.org/10.1093/bioinformatics/btz241DOI Listing
April 2019

The JAK2 46/1 (GGCC) MPN-predisposing haplotype: A risky haplotype, after all.

Am J Hematol 2019 Mar 18;94(3):283-285. Epub 2018 Dec 18.

CRIMM, Centro di Ricerca e Innovazione per le Malattie Mieloproliferative, Azienda Ospedaliera Universitaria Careggi, Dipartimento di Medicina Sperimentale e Clinica, Università degli Studi Firenze, and DENOTHE Excellence Center, Firenze, Italy.

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http://dx.doi.org/10.1002/ajh.25367DOI Listing
March 2019

Validation of the Mayo alliance prognostic system for mastocytosis.

Blood Cancer J 2019 02 11;9(2):18. Epub 2019 Feb 11.

CRIMM, Centro di Ricerca e Innovazione per le Malattie Mieloproliferative, Azienda Ospedaliera Universitaria Careggi, Dipartimento di Medicina Sperimentale e Clinica, Università degli Studi, Firenze, Italy.

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http://dx.doi.org/10.1038/s41408-019-0179-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370807PMC
February 2019

Mutation landscape in patients with myelofibrosis receiving ruxolitinib or hydroxyurea.

Blood Cancer J 2018 11 22;8(12):122. Epub 2018 Nov 22.

CRIMM, Centro di Ricerca e Innovazione per le Malattie Mieloproliferative, Azienda Ospedaliera Universitaria Careggi, Dipartimento di Medicina Sperimentale e Clinica, Università degli Studi, Firenze, Italy.

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http://dx.doi.org/10.1038/s41408-018-0152-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6250726PMC
November 2018

Classification and Personalized Prognosis in Myeloproliferative Neoplasms.

N Engl J Med 2018 10;379(15):1416-1430

From the Wellcome-MRC Cambridge Stem Cell Institute and Cambridge Institute for Medical Research (J.G., C.E.M., F.L.N., A.R.G., P.J.C.), the Department of Haematology, University of Cambridge (J.G., E.J.B., C.M., J.C., C.E.M., F.L.N., A.R.G.), and the Department of Haematology, Cambridge University Hospitals NHS Foundation Trust (J.G., E.J.B., A.L.G., C.M., J.C., A.R.G.), Cambridge, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus (J.N., D.C.W., N.A., E.P., G.G., L.O., S.O., J.W.T., A.P.B., N.W., P.J.C.), and the European Molecular Biology Laboratory, European Bioinformatics Institute (R.C., M.G.), Hinxton, Big Data Institute, University of Oxford, Oxford (D.C.W.), the Department of Haematology, Queen's University Belfast, Belfast (M.F.M.), and the Department of Haematology, Guy's and St. Thomas' NHS Foundation Trust, London (C.N.H.) - all in the United Kingdom; the Center for Molecular Oncology and the Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York (E.P., G.G.); the Department of Hematology, Zealand University Hospital, Roskilde, and the University of Copenhagen, Copenhagen (C.L.A., H.C.H.); and the Department of Experimental and Clinical Medicine, Center of Research and Innovation of Myeloproliferative Neoplasms, Azienda Ospedaliera Universitaria Careggi, University of Florence, Florence, Italy (P.G., A.M.V.).

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http://www.nejm.org/doi/10.1056/NEJMoa1716614
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http://dx.doi.org/10.1056/NEJMoa1716614DOI Listing
October 2018

JAK2 exon 12 mutated polycythemia vera: Mayo-Careggi MPN Alliance study of 33 consecutive cases and comparison with JAK2V617F mutated disease.

Am J Hematol 2018 08;93(4):E93-E96

Department of Experimental and Clinical Medicine, CRIMM, Center Research and Innovation of Myeloproliferative Neoplasms, Azienda Ospedaliera Universitaria Careggi, University of Florence, Florence, Italy.

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http://doi.wiley.com/10.1002/ajh.25017
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http://dx.doi.org/10.1002/ajh.25017DOI Listing
August 2018

GIPSS: genetically inspired prognostic scoring system for primary myelofibrosis.

Leukemia 2018 07 23;32(7):1631-1642. Epub 2018 Mar 23.

Department of Experimental and Clinical Medicine, CRIMM, Center Research and Innovation of Myeloproliferative Neoplasms, Azienda Ospedaliera Universitaria Careggi, University of Florence, Florence, Italy.

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http://dx.doi.org/10.1038/s41375-018-0107-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6035151PMC
July 2018

Myelofibrosis Treatment Algorithm 2018.

Blood Cancer J 2018 07 31;8(8):72. Epub 2018 Jul 31.

Department of Experimental and Clinical Medicine, CRIMM, Center Research and Innovation of Myeloproliferative Neoplasms, Azienda Ospedaliera Universitaria Careggi, University of Florence, Florence, Italy.

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http://dx.doi.org/10.1038/s41408-018-0109-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6068139PMC
July 2018

MIPSS70+ Version 2.0: Mutation and Karyotype-Enhanced International Prognostic Scoring System for Primary Myelofibrosis.

J Clin Oncol 2018 06 30;36(17):1769-1770. Epub 2018 Apr 30.

Ayalew Tefferi, Mayo Clinic, Rochester, MN; Paola Guglielmelli, University of Florence, Florence, Italy; Terra L. Lasho, Naseema Gangat, Rhett P. Ketterling, and Animesh Pardanani, Mayo Clinic, Rochester, MN; and Alessandro M. Vannucchi, University of Florence, Florence, Italy.

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http://dx.doi.org/10.1200/JCO.2018.78.9867DOI Listing
June 2018

Driver mutations and prognosis in primary myelofibrosis: Mayo-Careggi MPN alliance study of 1,095 patients.

Am J Hematol 2018 03 18;93(3):348-355. Epub 2017 Dec 18.

Department of Experimental and Clinical Medicine, CRIMM, Center Research and Innovation of Myeloproliferative Neoplasms, Azienda Ospedaliera Universitaria Careggi, University of Florence, Florence, Italy.

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http://dx.doi.org/10.1002/ajh.24978DOI Listing
March 2018

Polycythemia vera and essential thrombocythemia: algorithmic approach.

Curr Opin Hematol 2018 03;25(2):112-119

Department of Internal Medicine, Divisions of Hematology and Laboratory Medicine, Mayo Clinic, Rochester, Minnesota, USA.

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http://dx.doi.org/10.1097/MOH.0000000000000402DOI Listing
March 2018

Clonal architecture of JAK2V617F mutated cells during treatment with ruxolitinib.

Hematol Oncol 2018 Feb 5;36(1):357-359. Epub 2017 May 5.

CRIMM-Center for Research and Innovation of Myeloproliferative Neoplasms, AOU Careggi, Department of Experimental and Clinical medicine, University of Florence, Florence, Italy.

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http://dx.doi.org/10.1002/hon.2424DOI Listing
February 2018

MIPSS70: Mutation-Enhanced International Prognostic Score System for Transplantation-Age Patients With Primary Myelofibrosis.

J Clin Oncol 2018 02 9;36(4):310-318. Epub 2017 Dec 9.

Paola Guglielmelli, Giada Rotunno, Carmela Mannarelli, Annalisa Pacilli, Francesco Mannelli, and Alessandro M. Vannucchi, University of Florence, Azienda Ospedaliero Universitaria Careggi, Florence; Elisa Rumi, Vittorio Rosti, Giovanni Barosi, and Mario Cazzola, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo; Elisa Rumi and Mario Cazzola, University of Pavia, Pavia; Alessandro Rambaldi, University of Milan, Milan; Alessandro Rambaldi and Tiziano Barbui, Azienda Socio sanitaria Territoriale Papa Giovanni XXIII, Bergamo; Francesco Passamonti, University of Insubria, Varese, Italy; and Terra L. Lasho, Mythri Mudireddy, Maura Nicolosi, Animesh Pardanani, Curtis A. Hanson, Rhett P. Ketterling, Naseema Gangat, and Ayalew Tefferi, Mayo Clinic, Rochester, MN.

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http://dx.doi.org/10.1200/JCO.2017.76.4886DOI Listing
February 2018

What are the current treatment approaches for patients with polycythemia vera and essential thrombocythemia?

Hematology Am Soc Hematol Educ Program 2017 12;2017(1):480-488

Center of Research and Innovation of Myeloproliferative Neoplasms (CRIMM), Careggi University Hospital/University of Florence, Florence, Italy.

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http://dx.doi.org/10.1182/asheducation-2017.1.480DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6142598PMC
December 2017

Calreticulin affects hematopoietic stem/progenitor cell fate by impacting erythroid and megakaryocytic differentiation.

Stem Cells Dev 2017 Dec 19. Epub 2017 Dec 19.

Universita degli Studi di Modena e Reggio Emilia Dipartimento di Scienze della Vita, 117706, Centre for Regenerative Medicine, Department of Life Sciences , VIA CAMPI 287 , Modena, Italy , 41100 ;

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http://dx.doi.org/10.1089/scd.2017.0137DOI Listing
December 2017

Gender and survival in essential thrombocythemia: A two-center study of 1,494 patients.

Am J Hematol 2017 Nov 28;92(11):1193-1197. Epub 2017 Aug 28.

Department of Experimental and Clinical Medicine, CRIMM, Center Research and Innovation of Myeloproliferative Neoplasms, Azienda Ospedaliera Universitaria Careggi, University of Florence, Florence, Italy.

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http://dx.doi.org/10.1002/ajh.24882DOI Listing
November 2017

Inhibitors of the PI3K/mTOR pathway prevent STAT5 phosphorylation in mutated cells through PP2A/CIP2A axis.

Oncotarget 2017 Nov 22;8(57):96710-96724. Epub 2017 May 22.

CRIMM, Centro di Ricerca e Innovazione per le Malattie Mieloproliferative, Azienda Ospedaliera Universitaria Careggi, Florence, Italy.

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http://dx.doi.org/10.18632/oncotarget.18073DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5722516PMC
November 2017

A life-threatening ruxolitinib discontinuation syndrome.

Am J Hematol 2017 08 1;92(8):833-838. Epub 2017 Jun 1.

CRIMM, Centro di Ricerca e Innovazione per le Malattie Mieloproliferative, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy.

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http://dx.doi.org/10.1002/ajh.24775DOI Listing
August 2017

Traffic lights for ruxolitinib.

Blood 2017 08;130(9):1075-1077

UNIVERSITY OF FLORENCE.

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http://www.bloodjournal.org/lookup/doi/10.1182/blood-2017-07
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http://dx.doi.org/10.1182/blood-2017-07-795880DOI Listing
August 2017

Recommendations for molecular testing in classical Ph1-neg myeloproliferative disorders-A consensus project of the Italian Society of Hematology.

Leuk Res 2017 07 23;58:63-72. Epub 2017 Apr 23.

Center for the Study of Myelofibrosis, Biotechnology Research Area, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Policlinico S. Matteo, Pavia, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.leukres.2017.04.006DOI Listing
July 2017

Targeted deep sequencing in polycythemia vera and essential thrombocythemia.

Blood Adv 2016 Nov 22;1(1):21-30. Epub 2016 Nov 22.

Centro Ricerca e Innovazione Malattie Mieloproliferative, Azienda Ospedaliera Universitaria Careggi, and Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy; and.

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http://www.bloodadvances.org/lookup/doi/10.1182/bloodadvance
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http://dx.doi.org/10.1182/bloodadvances.2016000216DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5744051PMC
November 2016

The prognostic impact of bone marrow fibrosis in primary myelofibrosis.

Am J Hematol 2016 Oct 29;91(10):E454-5. Epub 2016 Jul 29.

CRIMM-Centro Ricerca E Innovazione Delle Malattie Mieloproliferative, Azienda Ospedaliera-Universitaria Careggi.

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http://dx.doi.org/10.1002/ajh.24482DOI Listing
October 2016

Germline transmission of LNKE208Q variant in a family with myeloproliferative neoplasms.

Am J Hematol 2016 09 4;91(9):E356. Epub 2016 Jul 4.

CRIMM, Centro Di Ricerca E Innovazione per Le Malattie Mieloproliferative, Azienda Ospedaliera Universitaria Careggi, Dipartimento di Medicina Sperimentale e Clinica, Università Degli Studi, Firenze, DENOTHE Excellence Center, Italy.

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http://dx.doi.org/10.1002/ajh.24437DOI Listing
September 2016

Prognostic impact of bone marrow fibrosis in primary myelofibrosis. A study of the AGIMM group on 490 patients.

Am J Hematol 2016 09 4;91(9):918-22. Epub 2016 Jul 4.

Department of Experimental and Clinical Medicine and DENOTHE Excellence Center, CRIMM-Center for Research and Innovation of Myeloproliferative Neoplasms, AOU Careggi, University of Florence, Florence, Italy.

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http://dx.doi.org/10.1002/ajh.24442DOI Listing
September 2016

Ruxolitinib is an effective treatment for CALR-positive patients with myelofibrosis.

Br J Haematol 2016 06 25;173(6):938-40. Epub 2015 Aug 25.

Laboratorio Congiunto per le Malattie Mieloproliferative, Università degli Studi di Firenze, Azienda Ospedaliera Universitaria Careggi, Florence, Italy.

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http://dx.doi.org/10.1111/bjh.13644DOI Listing
June 2016

STAT1 activation in association with JAK2 exon 12 mutations.

Haematologica 2016 Jan 3;101(1):e15-9. Epub 2015 Dec 3.

Cambridge Institute for Medical Research and Wellcome Trust/MRC Stem Cell Institute, University of Cambridge, UK Department of Haematology, Addenbrooke's Hospital, UK Department of Haematology, University of Cambridge, Cambridge, UK

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http://dx.doi.org/10.3324/haematol.2015.128546DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4697901PMC
January 2016

What Do Molecular Tests Add to Prognostic Stratification in MF: Is It Time to Add These to Our Clinical Practice?

Curr Hematol Malig Rep 2015 Dec;10(4):380-7

CRIMM-Centro Ricerca e Innovazione delle Malattie Mieloproliferative croniche, Azienda Ospedaliera Universitaria Careggi, Palazzina 27/B, Cubo 3 Largo Brambilla 3, 50134, Florence, Italy.

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http://dx.doi.org/10.1007/s11899-015-0285-yDOI Listing
December 2015

JAK2V617F complete molecular remission in polycythemia vera/essential thrombocythemia patients treated with ruxolitinib.

Blood 2015 May;125(21):3352-3

Laboratorio Congiunto Malattie Mieloproliferative Croniche, Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy Hematology Unit, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2015-01-62
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http://dx.doi.org/10.1182/blood-2015-01-624536DOI Listing
May 2015

Effect of mutation order on myeloproliferative neoplasms.

N Engl J Med 2015 Feb;372(7):601-612

Cambridge Institute for Medical Research and Wellcome Trust-Medical Research Council Stem Cell Institute (C.A.O., D.G.K., J.N., Y.S., J.G., E.J.B., C.E.M., A.L.G., D.D., A.R.G.) and Department of Hematology (C.A.O., D.G.K., J.N., Y.S., J.G., E.J.B., C.E.M., A.L.G., D.D., G.S.V., P.J.C., A.R.G.), University of Cambridge, Department of Haematology, Addenbrooke's Hospital (C.A.O., J.N., J.G., E.J.B., A.L.G., G.S.V., P.J.C., A.R.G.), Wellcome Trust Sanger Institute (D.C.W., E.P., G.S.V., P.J.C.), and Cancer Research U.K. Cambridge Institute, Li Ka Shing Centre (S.M.), Cambridge, and Guy's and St. Thomas' National Health Service Foundation Trust, Guy's Hospital, London (C.N.H.) - all in the United Kingdom; Dipartimento di Medicina Sperimentale e Clinica, University of Florence, Florence, Italy (P.G., A.V.); Departments of Pathology (B.B.) and Hematology (C.B.), Hospital del Mar, Barcelona; and the Department of Internal Medicine III, University Hospital of Ulm, Ulm, Germany (K.D.).

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http://dx.doi.org/10.1056/NEJMoa1412098DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4660033PMC
February 2015

Ruxolitinib-induced reversal of alopecia universalis in a patient with essential thrombocythemia.

Am J Hematol 2015 Jan;90(1):82-3

Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.

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http://dx.doi.org/10.1002/ajh.23871DOI Listing
January 2015

Calreticulin: a new horizon for the testing and treatment of myeloproliferative neoplasms.

Expert Rev Hematol 2014 Aug 22;7(4):423-5. Epub 2014 May 22.

Laboratorio Congiunto MMPC, Department of Experimental and Clinical Medicine, University of Florence, Azienda Ospedaliera Universitaria Careggi, Florence, Italy.

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http://dx.doi.org/10.1586/17474086.2014.920250DOI Listing
August 2014

Discriminating between essential thrombocythemia and masked polycythemia vera in JAK2 mutated patients.

Am J Hematol 2014 Jun 3;89(6):588-90. Epub 2014 Mar 3.

Research Foundation, Papa Giovanni XXIII Hospital, Bergamo, Italy; Division of Hematology, Papa Giovanni XXIII Hospital, Bergamo, Italy.

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http://dx.doi.org/10.1002/ajh.23694DOI Listing
June 2014

CALR mutations in myeloproliferative neoplasms: hidden behind the reticulum.

Am J Hematol 2014 May 11;89(5):453-6. Epub 2014 Mar 11.

Laboratorio Congiunto MMPC, Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.

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http://dx.doi.org/10.1002/ajh.23678DOI Listing
May 2014

Mutational analysis of BCORL1 in the leukemic transformation of chronic myeloproliferative neoplasms.

Ann Hematol 2014 Mar 21;93(3):523-4. Epub 2013 Jun 21.

Dipartimento di Medicina Sperimentale e Clinica, University of Florence, Largo Brambilla 3, 50134, Florence, Italy.

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http://dx.doi.org/10.1007/s00277-013-1827-9DOI Listing
March 2014

Impact of calreticulin mutations on clinical and hematological phenotype and outcome in essential thrombocythemia.

Blood 2014 Mar 26;123(10):1552-5. Epub 2013 Dec 26.

Department of Experimental and Clinical Medicine, University of Florence; and Azienda Ospedaliera-Universitaria Careggi, Florence, Italy.

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http://dx.doi.org/10.1182/blood-2013-11-538983DOI Listing
March 2014

Struggling with myelofibrosis-associated anemia.

Leuk Res 2013 Nov 27;37(11):1429-31. Epub 2013 Aug 27.

Dipartimento di Medicina Sperimentale e Clinica, University of Florence, Florence, Italy.

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https://linkinghub.elsevier.com/retrieve/pii/S01452126130029
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http://dx.doi.org/10.1016/j.leukres.2013.08.008DOI Listing
November 2013

Rationale for targeting the PI3K/Akt/mTOR pathway in myeloproliferative neoplasms.

Clin Lymphoma Myeloma Leuk 2013 Sep;13 Suppl 2:S307-9

Department of Medical and Surgical Care, Section of Hematology, University of Florence, Florence, Italy.

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http://dx.doi.org/10.1016/j.clml.2013.07.011DOI Listing
September 2013

JAK2 mutation-related disease and thrombosis.

Semin Thromb Hemost 2013 Jul 30;39(5):496-506. Epub 2013 Apr 30.

Sezione di Ematologia, Dipartimento di Medicina Clinica e Sperimentale, Università degli Studi di Firenze, Largo Brambilla 3, Florence, Italy.

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http://dx.doi.org/10.1055/s-0033-1343890DOI Listing
July 2013

Improving survival trends in primary myelofibrosis: an international study.

J Clin Oncol 2012 Aug 23;30(24):2981-7. Epub 2012 Jul 23.

Hospital Clínic, Institut d’Investigació Biomèdica August Pi i Sunyer, University of Barcelona, Spain.

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http://dx.doi.org/10.1200/JCO.2012.42.0240DOI Listing
August 2012

BCR-ABL1-negative chronic myeloid neoplasms: an update on management techniques.

Future Oncol 2012 May;8(5):575-93

Section of Hematology, Department of Critical Care, University of Florence, Largo Brambilla 3, 50134 Florence, Italy.

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http://dx.doi.org/10.2217/fon.12.50DOI Listing
May 2012