Paola Dongiovanni

Paola Dongiovanni

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Paola Dongiovanni

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Lipid accumulation impairs lysosomal acid lipase activity in hepatocytes: Evidence in NAFLD patients and cell cultures.

Biochim Biophys Acta Mol Cell Biol Lipids 2019 Sep 7:158523. Epub 2019 Sep 7.

Department of Pathophysiology and Transplantation, Unit of Metabolic and Internal Medicine, University of Milan, Ca' Granda IRCCS Foundation, Maggiore Policlinico Hospital, Milan, Italy.

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http://dx.doi.org/10.1016/j.bbalip.2019.158523DOI Listing
September 2019

FGF23 and Fetuin-A Interaction in the Liver and in the Circulation.

Int J Biol Sci 2018 25;14(6):586-598. Epub 2018 Apr 25.

Renal Research Laboratory Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy.

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http://dx.doi.org/10.7150/ijbs.23256DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6001652PMC
June 2019

Genetic and Epigenetic Modifiers of Alcoholic Liver Disease.

Int J Mol Sci 2018 Dec 3;19(12). Epub 2018 Dec 3.

General Medicine and Metabolic Diseases, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Pad. Granelli, via F Sforza 35, 20122 Milan, Italy.

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http://www.mdpi.com/1422-0067/19/12/3857
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http://dx.doi.org/10.3390/ijms19123857DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320903PMC
December 2018

FibroScan Detects Cardiovascular Damage in Patients With NAFLD.

Clin Gastroenterol Hepatol 2018 Dec 8. Epub 2018 Dec 8.

Department of Pathophysiology and Transplantation Ca' Granda IRCCS Foundation, Policlinico Hospital, University of Milan, Milan, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.cgh.2018.11.011DOI Listing
December 2018

miRNA Signature in NAFLD: A Turning Point for a Non-Invasive Diagnosis.

Int J Mol Sci 2018 Dec 10;19(12). Epub 2018 Dec 10.

General Medicine and Metabolic Diseases, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano 20122, Italy.

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http://dx.doi.org/10.3390/ijms19123966DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320931PMC
December 2018

Degradation of PHLPP2 by KCTD17, via a Glucagon-Dependent Pathway, Promotes Hepatic Steatosis.

Gastroenterology 2017 12 30;153(6):1568-1580.e10. Epub 2017 Aug 30.

Department of Medicine, Columbia University, New York, NY. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2017.08.039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5705280PMC
December 2017

Liver and Cardiovascular Damage in Patients With Lean Nonalcoholic Fatty Liver Disease, and Association With Visceral Obesity.

Clin Gastroenterol Hepatol 2017 Oct 26;15(10):1604-1611.e1. Epub 2017 May 26.

Department of Pathophysiology and Transplantation, Unit of Metabolic and Internal Medicine, University of Milan, Milan, Italy.

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http://dx.doi.org/10.1016/j.cgh.2017.04.045DOI Listing
October 2017

Mutant PNPLA3 I148M protein as pharmacological target for liver disease.

Hepatology 2017 10 26;66(4):1026-1028. Epub 2017 Aug 26.

Internal Medicine and Metabolic Diseases, Fondazione IRCCS Ca' Granda Ospedale Policlinico Milano, Milan, Italy.

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http://doi.wiley.com/10.1002/hep.29298
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http://dx.doi.org/10.1002/hep.29298DOI Listing
October 2017

Iron overload induces hypogonadism in male mice via extrahypothalamic mechanisms.

Mol Cell Endocrinol 2017 10 23;454:135-145. Epub 2017 Jun 23.

Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, 20133 Milan, Italy.

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http://dx.doi.org/10.1016/j.mce.2017.06.019DOI Listing
October 2017

A Nutrigenomic Approach to Non-Alcoholic Fatty Liver Disease.

Int J Mol Sci 2017 Jul 16;18(7). Epub 2017 Jul 16.

Internal Medicine and Metabolic Diseases, Fondazione IRCCS Ca' Granda Ospedale Policlinico Milano, Milan 20122, Italy.

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http://dx.doi.org/10.3390/ijms18071534DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5536022PMC
July 2017

GNPAT p.D519G variant and iron metabolism during oral iron tolerance test.

Hepatology 2017 01 24;65(1):384-385. Epub 2016 Aug 24.

Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Internal Medicine and Metabolic Diseases, Fondazione IRCCS Ca' Granda Ospedale, Maggiore Policlinico, Milan, Italy.

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http://dx.doi.org/10.1002/hep.28745DOI Listing
January 2017

The role of insulin resistance in nonalcoholic steatohepatitis and liver disease development--a potential therapeutic target?

Expert Rev Gastroenterol Hepatol 2016 5;10(2):229-42. Epub 2015 Dec 5.

a Department of Pathophysiology and Transplantation , Università degli Studi di Milano, and Internal Medicine and Metabolic Diseases, Fondazione IRCCS Ca' Granda Ospedale Policlinico Milano , Milano , Italy.

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http://dx.doi.org/10.1586/17474124.2016.1110018DOI Listing
November 2016

Hepcidin resistance in dysmetabolic iron overload.

Liver Int 2016 10 6;36(10):1540-8. Epub 2016 Apr 6.

Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Milan, Italy.

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http://dx.doi.org/10.1111/liv.13124DOI Listing
October 2016

Genetics of nonalcoholic fatty liver disease.

Metabolism 2016 Aug 1;65(8):1026-37. Epub 2015 Sep 1.

Internal Medicine and Metabolic Diseases, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico; Department of Pathophysiology and Transplantation, Università degli Studi Milano, Milan, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.metabol.2015.08.018DOI Listing
August 2016

Liver fat accumulation is associated with circulating PCSK9.

Ann Med 2016 08 25;48(5):384-91. Epub 2016 May 25.

d Internal Medicine and Metabolic Diseases , Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico , Milano , Italy ;

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http://dx.doi.org/10.1080/07853890.2016.1188328DOI Listing
August 2016

Genetic Factors in the Pathogenesis of Nonalcoholic Fatty Liver and Steatohepatitis.

Biomed Res Int 2015 27;2015:460190. Epub 2015 Jul 27.

Internal Medicine and Metabolic Diseases, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Via Francesco Sforza 35, 20122 Milan, Italy ; Department of Pathophysiology and Transplantation, University of Milan, Via Francesco Sforza 35, 20122 Milan, Italy.

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http://downloads.hindawi.com/journals/bmri/2015/460190.pdf
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http://www.hindawi.com/journals/bmri/2015/460190/
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http://dx.doi.org/10.1155/2015/460190DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4530215PMC
May 2016

The MBOAT7-TMC4 Variant rs641738 Increases Risk of Nonalcoholic Fatty Liver Disease in Individuals of European Descent.

Gastroenterology 2016 05 2;150(5):1219-1230.e6. Epub 2016 Feb 2.

Department of Molecular and Clinical Medicine, University of Gothenburg, Sweden; Clinical Nutrition Unit, Department of Medical and Surgical Sciences, University Magna Graecia, Catanzaro, Italy; Cardiology Department, Sahlgrenska University Hospital, Gothenburg, Sweden. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2016.01.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4844071PMC
May 2016

CDKN1A: a double-edged sword in fatty liver?

Cell Cycle 2014 3;13(9):1371-2. Epub 2014 Apr 3.

Internal Medicine; Fondazione IRCCS Ca' Granda Ospedale Policlinico Milano; Milan, Italy.

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http://dx.doi.org/10.4161/cc.28754DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4050133PMC
April 2016

Nutritional therapy for nonalcoholic fatty liver disease.

J Nutr Biochem 2016 Mar 23;29:1-11. Epub 2015 Oct 23.

Internal Medicine and Metabolic Diseases, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20122 Milano, Italy; Department of Pathophysiology and Transplantation (DEPT), Università degli Studi di Milano, 20122 Milano, Italy.

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http://dx.doi.org/10.1016/j.jnutbio.2015.08.024DOI Listing
March 2016

High fat diet subverts hepatocellular iron uptake determining dysmetabolic iron overload.

PLoS One 2015 3;10(2):e0116855. Epub 2015 Feb 3.

Internal Medicine and Metabolic Diseases, Fondazione IRCCS Ca' Granda Ospedale Policlinico, Milano, Italy; Department of Pathophysiology and Transplantation, Metabolic Liver Diseases Research Center, Università degli Studi di Milano, Milano, Italy.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0116855PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4315491PMC
January 2016

Reply to "Statin treatment for non-alcoholic steatohepatitis".

J Hepatol 2016 Jan 8;64(1):242-3. Epub 2015 Oct 8.

Internal Medicine, Fondazione IRCCS Ca' Granda Ospedale Policlinico Milano, Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Milan, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2015.09.023DOI Listing
January 2016

Increased circulating adiponectin in males with chronic HCV hepatitis.

Eur J Intern Med 2015 Oct 17;26(8):635-9. Epub 2015 Aug 17.

Internal Medicine, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico Milano, Department of Pathophysiology and Transplantation, Centro Malattie Metaboliche del Fegato, Università degli Studi di Milano, Milano, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.ejim.2015.08.001DOI Listing
October 2015

Statin use and non-alcoholic steatohepatitis in at risk individuals.

J Hepatol 2015 Sep 14;63(3):705-12. Epub 2015 May 14.

Internal Medicine, Fondazione IRCCS Ca' Granda Ospedale Policlinico Milano, Milan, Italy; Department of Pathophysiology and Transplantation (R.R., S.F., L.V.), Università degli Studi di Milano, Milan, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2015.05.006DOI Listing
September 2015

Reply: To PMID 25251399.

Hepatology 2015 Aug 17;62(2):660. Epub 2015 Jun 17.

Department of Internal Medicine and Metabolic Diseases, Fondazione IRCCS Ca' Granda Ospedale Policlinico Milano, Pad. Granelli, Milano, Italy.

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http://dx.doi.org/10.1002/hep.27642DOI Listing
August 2015

PNPLA3 I148M Variant Influences Circulating Retinol in Adults with Nonalcoholic Fatty Liver Disease or Obesity.

J Nutr 2015 Aug 1;145(8):1687-91. Epub 2015 Jul 1.

Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg, Sweden; Department of Medical and Surgical Sciences, Clinical Nutrition Unit, University Magna Graecia of Catanzaro, Catanzaro, Italy; and Department of Cardiology, Sahlgrenska University Hospital, Gothenburg, Sweden

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http://dx.doi.org/10.3945/jn.115.210633DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4516767PMC
August 2015

Interaction between PNPLA3 I148M variant and age at infection in determining fibrosis progression in chronic hepatitis C.

PLoS One 2014 29;9(8):e106022. Epub 2014 Aug 29.

Department of Internal Medicine, Fondazione IRCCS Ca' Granda Ospedale Policlinico Milano, Milano, Italy; Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Milano, Italy.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0106022PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4149487PMC
June 2015

Juvenile hemochromatosis associated with heterozygosity for novel hemojuvelin mutations and with unknown cofactors.

Ann Hepatol 2014 Sep-Oct;13(5):568-71

Internal Medicine, Fondazione IRCCS Ca' Granda Ospedale Policlinico, Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Milan, Italy.

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May 2015

The UCP2 -866 G>A promoter region polymorphism is associated with nonalcoholic steatohepatitis.

Liver Int 2015 May 20;35(5):1574-80. Epub 2014 Nov 20.

Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Fondazione IRCCS Ca' Granda Ospedale Policlinico Milano, Milan, Italy.

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http://dx.doi.org/10.1111/liv.12707DOI Listing
May 2015

Hepatocellular carcinoma in nonalcoholic fatty liver: role of environmental and genetic factors.

World J Gastroenterol 2014 Sep;20(36):12945-55

Paola Dongiovanni, Luca Valenti, Internal Medicine 1B, Fondazione IRCCS Ca' Granda Ospedale Policlinico, 20122 Milano, Italy.

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http://dx.doi.org/10.3748/wjg.v20.i36.12945DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4177475PMC
September 2014

PNPLA3 has retinyl-palmitate lipase activity in human hepatic stellate cells.

Hum Mol Genet 2014 Aug 25;23(15):4077-85. Epub 2014 Mar 25.

Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Center for Cardiovascular and Metabolic Research, Wallenberg Laboratory and Department of Medical and Surgical Sciences, Clinical Nutrition Unit, University Magna Graecia of Catanzaro, Catanzaro, Italy

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http://dx.doi.org/10.1093/hmg/ddu121DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4082369PMC
August 2014

Hepatic steatosis and PNPLA3 I148M variant are associated with serum Fetuin-A independently of insulin resistance.

Eur J Clin Invest 2014 Jul;44(7):627-33

Department of Pathophysiology and Transplantation, Internal Medicine, Fondazione IRCCS Ca' Granda Ospedale Policlinico Milano, Università degli Studi di Milano, Milano, Italy.

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http://dx.doi.org/10.1111/eci.12280DOI Listing
July 2014

PNPLA3 I148M polymorphism, clinical presentation, and survival in patients with hepatocellular carcinoma.

PLoS One 2013 14;8(10):e75982. Epub 2013 Oct 14.

Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Milano, Italy ; Internal Medicine, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Ca' Granda - Ospedale Maggiore Policlinico Milano, Milano, Italy.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0075982PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3796509PMC
June 2014

A randomized trial of iron depletion in patients with nonalcoholic fatty liver disease and hyperferritinemia.

World J Gastroenterol 2014 Mar;20(11):3002-10

Luca Valenti, Anna Ludovica Fracanzani, Paola Dongiovanni, Serena Rovida, Raffaela Rametta, Erika Fatta, Edoardo Alessandro Pulixi, Silvia Fargion, Department of Pathophysiology and Transplantation, Metabolic Liver Diseases Research Center, Università degli Studi di Milano, Fondazione IRCCS Ca' Granda Ospedale Policlinico, via F Sforza 35, 20122, Milano, Italy.

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http://www.wjgnet.com/1007-9327/full/v20/i11/3002.htm
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http://dx.doi.org/10.3748/wjg.v20.i11.3002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3961977PMC
March 2014

Genetic predisposition in NAFLD and NASH: impact on severity of liver disease and response to treatment.

Curr Pharm Des 2013 ;19(29):5219-38

Department of Pathophysiology and Transplantation, section Internal Medicine, Università degli Studi Milano, UO Medicina Interna1B, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3850262PMC
http://dx.doi.org/10.2174/13816128113199990381DOI Listing
February 2014

PNPLA3 I148M polymorphism and progressive liver disease.

World J Gastroenterol 2013 Nov;19(41):6969-78

Paola Dongiovanni, Benedetta Donati, Roberta Fares, Rosa Lombardi, Luca Valenti, Internal Medicine, Fondazione IRCCS Ca' Granda Ospedale Policlinico Milano, Department of Pathophysiology and Transplantation, Università degli Studi di Milano, 20122 Milano, Italy.

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http://dx.doi.org/10.3748/wjg.v19.i41.6969DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3819533PMC
November 2013

PNPLA3 I148M variant and hepatocellular carcinoma: a common genetic variant for a rare disease.

Dig Liver Dis 2013 Aug 16;45(8):619-24. Epub 2013 Jan 16.

Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Section of Internal Medicine, Italy.

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http://dx.doi.org/10.1016/j.dld.2012.12.006DOI Listing
August 2013

A novel alpha1-antitrypsin null variant (PiQ0Milano ).

World J Hepatol 2013 Aug;5(8):458-61

Raffaela Rametta, Silvia Fargion, Luca Valenti, Department of Pathophysiology and Transplantation, Università degli Studi di Milano, 20122 Milano, Italy.

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http://dx.doi.org/10.4254/wjh.v5.i8.458DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3767846PMC
August 2013

Dietary iron overload induces visceral adipose tissue insulin resistance.

Am J Pathol 2013 Jun 8;182(6):2254-63. Epub 2013 Apr 8.

Department of Pathophysiology and Transplantation, Centro Malattie Metaboliche del Fegato, Università degli Studi di Milano, and Internal Medicine, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano, Italy.

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http://dx.doi.org/10.1016/j.ajpath.2013.02.019DOI Listing
June 2013

The A736V TMPRSS6 polymorphism influences hepatic iron overload in nonalcoholic fatty liver disease.

PLoS One 2012 5;7(11):e48804. Epub 2012 Nov 5.

Department of Pathophysiology and Transplantation, Section Internal Medicine, Università degli Studi, Fondazione Ca' Granda IRCCS Ospedale Maggiore Policlinico, Milano, Italy.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0048804PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3489825PMC
May 2013

Liver transplantation for hepatocellular carcinoma in a patient with a novel telomerase mutation and steatosis.

J Hepatol 2013 Feb 19;58(2):399-401. Epub 2012 Sep 19.

Section of Internal Medicine, Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Italy.

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http://dx.doi.org/10.1016/j.jhep.2012.09.011DOI Listing
February 2013

Peroxisome proliferator-activated receptor genetic polymorphisms and nonalcoholic Fatty liver disease: any role in disease susceptibility?

PPAR Res 2013 4;2013:452061. Epub 2013 Feb 4.

Section of Internal Medicine, Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Pad. Granelli, Via F Sforza 35, 20122 Milano, Italy.

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http://dx.doi.org/10.1155/2013/452061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3575610PMC
February 2013

The A736V TMPRSS6 polymorphism influences hepcidin and iron metabolism in chronic hemodialysis patients: TMPRSS6 and hepcidin in hemodialysis.

BMC Nephrol 2013 Feb 22;14:48. Epub 2013 Feb 22.

Department of Pathophysiology and Transplantation, Internal Medicine, Università degli Studi di Milano, Fondazione IRCCS Ca' Granda Ospedale Policlinico Milano, Milano, Italy.

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http://dx.doi.org/10.1186/1471-2369-14-48DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3585892PMC
February 2013

Effect of the A736V TMPRSS6 polymorphism on the penetrance and clinical expression of hereditary hemochromatosis.

J Hepatol 2012 Dec 8;57(6):1319-25. Epub 2012 Aug 8.

Department of Internal Medicine, UO Medicina Interna 1B, Università degli Studi, Fondazione Ca' Granda IRCCS Ospedale Maggiore Policlinico, Milano, Italy.

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http://linkinghub.elsevier.com/retrieve/pii/S016882781200617
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http://dx.doi.org/10.1016/j.jhep.2012.07.041DOI Listing
December 2012

Diagnostic and therapeutic implications of the association between ferritin level and severity of nonalcoholic fatty liver disease.

World J Gastroenterol 2012 Aug;18(29):3782-6

Università degli Studi di Milano, Fondazione Ca' Granda IRCCS Ospedale Maggiore Policlinico, Milan, Italy.

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http://dx.doi.org/10.3748/wjg.v18.i29.3782DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3413047PMC
August 2012

The I148M PNPLA3 polymorphism influences serum adiponectin in patients with fatty liver and healthy controls.

BMC Gastroenterol 2012 Aug 16;12:111. Epub 2012 Aug 16.

Department of Internal Medicine, Università degli Studi Milano, UO Medicina Interna 1B, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.

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http://dx.doi.org/10.1186/1471-230X-12-111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3444917PMC
August 2012

LPIN1 rs13412852 polymorphism in pediatric nonalcoholic fatty liver disease.

J Pediatr Gastroenterol Nutr 2012 May;54(5):588-93

Department of Internal Medicine, Università degli Studi, Ospedale Maggiore Policlinico Ca' Granda IRCCS, Milan, Italy.

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http://dx.doi.org/10.1097/MPG.0b013e3182442a55DOI Listing
May 2012

The APOC3 T-455C and C-482T promoter region polymorphisms are not associated with the severity of liver damage independently of PNPLA3 I148M genotype in patients with nonalcoholic fatty liver.

J Hepatol 2011 Dec 21;55(6):1409-14. Epub 2011 Jul 21.

Department of Internal Medicine, Università degli Studi Milano, UO Medicina Interna 1B, Ospedale Maggiore Ca' Granda Fondazione Policlinico IRCCS, Milan, Italy.

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http://dx.doi.org/10.1016/j.jhep.2011.03.035DOI Listing
December 2011

Iron in fatty liver and in the metabolic syndrome: a promising therapeutic target.

J Hepatol 2011 Oct 28;55(4):920-32. Epub 2011 Jun 28.

Department of Internal Medicine, Centro Malattie Metaboliche del Fegato, Università degli Studi di Milano, and Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.

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http://dx.doi.org/10.1016/j.jhep.2011.05.008DOI Listing
October 2011

Serum hepcidin and macrophage iron correlate with MCP-1 release and vascular damage in patients with metabolic syndrome alterations.

Arterioscler Thromb Vasc Biol 2011 Mar 23;31(3):683-90. Epub 2010 Dec 23.

Centro Malattie Metaboliche del Fegato, Department of Internal Medicine, Università degli Studi, Ospedale Maggiore Policlinico Ca' Granda IRCCS, Milano, Via F Sforza 35, 20122 Milano, Italy.

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http://dx.doi.org/10.1161/ATVBAHA.110.214858DOI Listing
March 2011

Patatin-like phospholipase domain-containing 3 I148M polymorphism, steatosis, and liver damage in chronic hepatitis C.

Hepatology 2011 Mar 11;53(3):791-9. Epub 2011 Feb 11.

Department of Internal Medicine, Università degli Studi, Fondazione IRCCS Ospedale Maggiore Policlinico "Ca' Granda" IRCCS, Milan, Italy.

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http://doi.wiley.com/10.1002/hep.24123
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http://dx.doi.org/10.1002/hep.24123DOI Listing
March 2011

Beta-globin mutations are associated with parenchymal siderosis and fibrosis in patients with non-alcoholic fatty liver disease.

J Hepatol 2010 Nov 25;53(5):927-33. Epub 2010 Jul 25.

Department of Internal Medicine, Università degli Studi Milano, UO Medicina Interna 1B, Fondazione Ospedale Policlinico MaRE IRCCS, Milan, Italy.

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http://dx.doi.org/10.1016/j.jhep.2010.05.023DOI Listing
November 2010

I148M patatin-like phospholipase domain-containing 3 gene variant and severity of pediatric nonalcoholic fatty liver disease.

Hepatology 2010 Oct;52(4):1274-80

Department of Internal Medicine, Università degli Studi, Ospedale Maggiore Policlinico (Ca' Granda) Istituto di Ricovero e Cura a Carattere Scientifico, Milan, Italy.

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http://dx.doi.org/10.1002/hep.23823DOI Listing
October 2010

Serum hyaluronic acid for the screening of progressive nonalcoholic steatohepatitis in children: a promising approach.

Transl Res 2010 Oct 8;156(4):226-8. Epub 2010 Jul 8.

Centro Malattie Metaboliche del Fegato, Department of Internal Medicine, Università degli Studi, Ospedale Maggiore Policlinico Ca' Granda IRCCS, Milano Via F Sforza 35, Milano, Italy.

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http://dx.doi.org/10.1016/j.trsl.2010.06.004DOI Listing
October 2010

Lack of association between peroxisome proliferator-activated receptors alpha and gamma2 polymorphisms and progressive liver damage in patients with non-alcoholic fatty liver disease: a case control study.

BMC Gastroenterol 2010 Sep 8;10:102. Epub 2010 Sep 8.

Department of Internal Medicine, Metabolic Liver Diseases Research Center, Università degli Studi di Milano, Fondazione Ospedale Policlinico Ca' Granda IRCCS, Milano, Italy.

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http://dx.doi.org/10.1186/1471-230X-10-102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2944335PMC
September 2010

Homozygosity for the patatin-like phospholipase-3/adiponutrin I148M polymorphism influences liver fibrosis in patients with nonalcoholic fatty liver disease.

Hepatology 2010 Apr;51(4):1209-17

Department of Internal Medicine, Università degli Studi Milano, UO Medicina Interna 1B, Fondazione Ospedale Policlinico MaRE Istituto di Ricovero e Cura a Carattere Scientifico, Milan, Italy.

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http://dx.doi.org/10.1002/hep.23622DOI Listing
April 2010

HFE genotype, parenchymal iron accumulation, and liver fibrosis in patients with nonalcoholic fatty liver disease.

Gastroenterology 2010 Mar 18;138(3):905-12. Epub 2009 Nov 18.

Department of Internal Medicine, Università degli Studi di Milano, Ospedale Maggiore Policlinico IRCCS, Milano, Italy.

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http://dx.doi.org/10.1053/j.gastro.2009.11.013DOI Listing
March 2010

Iron-dependent regulation of MDM2 influences p53 activity and hepatic carcinogenesis.

Am J Pathol 2010 Feb 17;176(2):1006-17. Epub 2009 Dec 17.

Center of Metabolic and Liver Diseases, Department of Internal Medicine, University of Milano, Ospedale Policlinico Mangiagalli e Regina Elena Fondazione IRCCS, 20122 Milano, Italy.

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http://dx.doi.org/10.2353/ajpath.2010.090249DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2808103PMC
February 2010

HFE mutations modulate the effect of iron on serum hepcidin-25 in chronic hemodialysis patients.

Clin J Am Soc Nephrol 2009 Aug 18;4(8):1331-7. Epub 2009 Jun 18.

Center for Metabolic and Liver Diseases, Department of Internal Medicine, Universitá degli Studi di Milano,Fondazione Ospedale Maggiore Policlinico MaRE IRCCS, Via F Sforza 35, 20122 Milano, Italy.

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http://dx.doi.org/10.2215/CJN.01370209DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2723967PMC
August 2009

HFE genotype influences erythropoiesis support requirement in hemodialysis patients: a prospective study.

Am J Nephrol 2008 16;28(2):311-6. Epub 2007 Nov 16.

Department of Internal Medicine, University of Milan, Ospedale Policlinico Mangiagalli e Regina Elena Fondazione IRCCS, Milan, Italy.

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http://dx.doi.org/10.1159/000111387DOI Listing
May 2008

Increased expression and activity of the transcription factor FOXO1 in nonalcoholic steatohepatitis.

Diabetes 2008 May 3;57(5):1355-62. Epub 2008 Mar 3.

Department of Internal Medicine, Ospedale Maggiore Policlinico Mangiagalli Regina Elena IRCCS (Istituto di Ricovero e Cura a Carattere Scientifico), University of Milan, Milan, Italy.

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http://dx.doi.org/10.2337/db07-0714DOI Listing
May 2008

HFE mutations in nonalcoholic fatty liver disease.

Hepatology 2008 May;47(5):1794-5; author reply 1795-6

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http://dx.doi.org/10.1002/hep.22059DOI Listing
May 2008

Iron genes, dysmetabolism and fibrosis in chronic hepatitis C.

J Hepatol 2008 Mar 31;48(3):513-4; author reply 514-5. Epub 2007 Dec 31.

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http://dx.doi.org/10.1016/j.jhep.2007.12.001DOI Listing
March 2008

Iron depletion by deferoxamine up-regulates glucose uptake and insulin signaling in hepatoma cells and in rat liver.

Am J Pathol 2008 Mar 2;172(3):738-47. Epub 2008 Feb 2.

Department of Internal Medicine, Ospedale Maggiore Policlinico Mangiagalli Regina Elena Istituto Ricovero e Cura a Carattere Scientifico, Milano, Italy.

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http://dx.doi.org/10.2353/ajpath.2008.070097DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2258266PMC
March 2008

Relative contribution of iron genes, dysmetabolism and hepatitis C virus (HCV) in the pathogenesis of altered iron regulation in HCV chronic hepatitis.

Haematologica 2007 Aug 20;92(8):1037-42. Epub 2007 Jul 20.

Department of Internal Medicine, Medicina Interna IB, Universita' di Milano, Ospedale Policlinico Mangiagalli Regina Elena IRCCS, Milano, Italy.

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http://dx.doi.org/10.3324/haematol.11281DOI Listing
August 2007

Iron depletion by phlebotomy improves insulin resistance in patients with nonalcoholic fatty liver disease and hyperferritinemia: evidence from a case-control study.

Am J Gastroenterol 2007 Jun 27;102(6):1251-8. Epub 2007 Mar 27.

Department of Internal Medicine, Universita' di Milano, Ospedale Policlinico Mangiagalli Regina Elena IRCCS, Milano, Italy.

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http://dx.doi.org/10.1111/j.1572-0241.2007.01192.xDOI Listing
June 2007

HFE gene mutations and oxidative stress influence serum ferritin, associated with vascular damage, in hemodialysis patients.

Am J Nephrol 2007 13;27(1):101-7. Epub 2007 Feb 13.

Department of Internal Medicine, University of Milano, Ospedale Policlinico Mangiagalli e Regina Elena Fondazione IRCCS, Milano, Italy.

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http://dx.doi.org/10.1159/000099635DOI Listing
April 2007

TNFalpha genotype affects TNFalpha release, insulin sensitivity and the severity of liver disease in HCV chronic hepatitis.

J Hepatol 2005 Dec 5;43(6):944-50. Epub 2005 Jul 5.

Dipartimento di Medicina Interna, Ospedale Maggiore IRCCS, Università degli Studi, Pad Granelli, Via F Sforza 35, 20122 Milano, Italy.

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http://dx.doi.org/10.1016/j.jhep.2005.05.035DOI Listing
December 2005

TNFalpha promoter polymorphisms.

Methods Mol Med 2004 ;98:47-58

Department of Internal Medicine, Universitá delgi Studi, Milan, Italy.

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http://dx.doi.org/10.1385/1-59259-771-8:047DOI Listing
April 2004