Paola Chiarugi

Paola Chiarugi

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Paola Chiarugi

Publications by authors named "Paola Chiarugi"

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Stromal-induced downregulation of miR-1247 promotes prostate cancer malignancy.

J Cell Physiol 2019 Jun 30;234(6):8274-8285. Epub 2018 Oct 30.

Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy.

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http://doi.wiley.com/10.1002/jcp.27679
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http://dx.doi.org/10.1002/jcp.27679DOI Listing
June 2019

Stromal-induced mitochondrial re-education: Impact on epithelial-to-mesenchymal transition and cancer aggressiveness.

Semin Cell Dev Biol 2019 May 21. Epub 2019 May 21.

Department of Experimental and Clinical Biomedical Sciences, University of Florence, 50134 Florence, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.semcdb.2019.05.009DOI Listing
May 2019

Lactate: A Metabolic Driver in the Tumour Landscape.

Trends Biochem Sci 2019 02 22;44(2):153-166. Epub 2018 Nov 22.

Department of Experimental and Clinical Biomedical Sciences, University of Florence, 50134 Florence, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.tibs.2018.10.011DOI Listing
February 2019

Zoledronic Acid Inhibits the RhoA-mediated Amoeboid Motility of Prostate Cancer Cells.

Curr Cancer Drug Targets 2019 Jan 15. Epub 2019 Jan 15.

Dipartimento di Medicina Sperimentale e Clinica, Università degli Studi di Firenze, Viale Morgagni 50, 50142 Firenze. Italy.

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http://dx.doi.org/10.2174/1568009619666190115142858DOI Listing
January 2019

Increased Lactate Secretion by Cancer Cells Sustains Non-cell-autonomous Adaptive Resistance to MET and EGFR Targeted Therapies.

Cell Metab 2018 12 30;28(6):848-865.e6. Epub 2018 Aug 30.

Candiolo Cancer Institute - FPO, IRCCS, Strada Provinciale 142, Torino, Candiolo 10060, Italy; University of Torino, Department of Oncology, 10060, Torino, Candiolo, Italy. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15504131183050
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http://dx.doi.org/10.1016/j.cmet.2018.08.006DOI Listing
December 2018

MYC Mediates Large Oncosome-Induced Fibroblast Reprogramming in Prostate Cancer.

Cancer Res 2017 05 15;77(9):2306-2317. Epub 2017 Feb 15.

Division of Cancer Biology and Therapeutics, Departments of Surgery, Biomedical Sciences and Pathology and Laboratory Medicine, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California.

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http://dx.doi.org/10.1158/0008-5472.CAN-16-2942DOI Listing
May 2017

Multiwalled carbon nanotubes for drug delivery: Efficiency related to length and incubation time.

Int J Pharm 2017 Apr 13;521(1-2):69-72. Epub 2017 Feb 13.

Chemistry Department "Ugo Schiff", Università di Firenze, Via della Lastruccia 3-13, 50019 Sesto Fiorentino (Fi), Italy.

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http://dx.doi.org/10.1016/j.ijpharm.2017.02.023DOI Listing
April 2017

Targeting the Metabolic Reprogramming That Controls Epithelial-to-Mesenchymal Transition in Aggressive Tumors.

Front Oncol 2017 14;7:40. Epub 2017 Mar 14.

Department of Experimental and Clinical Biomedical Sciences, University of Florence , Florence , Italy.

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http://dx.doi.org/10.3389/fonc.2017.00040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5348536PMC
March 2017

Nutrient Exploitation within the Tumor-Stroma Metabolic Crosstalk.

Trends Cancer 2016 12 6;2(12):736-746. Epub 2016 Dec 6.

Department of Experimental and Clinical Biomedical Sciences, University of Florence, Viale G.B. Morgagni, 50, 50134 Florence, Italy; Tuscany Tumor Institute (ITT) and Excellence Centre for Research, Transfer and High Education DenoTHE, Florence, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.trecan.2016.11.001DOI Listing
December 2016

Mesenchymal Stem Cells are Recruited and Activated into Carcinoma-Associated Fibroblasts by Prostate Cancer Microenvironment-Derived TGF-β1.

Stem Cells 2016 10 4;34(10):2536-2547. Epub 2016 Jul 4.

Department of Experimental and Clinical Biomedical Sciences, University of Florence, Tuscany Tumor Institute and "Center for Research, Transfer and High Education DenoTHE", Florence, Italy.

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http://dx.doi.org/10.1002/stem.2412DOI Listing
October 2016

Down-Regulation of SOX2 Underlies the Inhibitory Effects of the Triphenylmethane Gentian Violet on Melanoma Cell Self-Renewal and Survival.

J Invest Dermatol 2016 10 29;136(10):2059-2069. Epub 2016 Jun 29.

Core Research Laboratory-Istituto Toscano Tumori, Viale Pieraccini 6, Florence, Italy; Department of Oncology, Careggi University Hospital, Florence, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.jid.2016.06.610DOI Listing
October 2016

Metabolic exchanges within tumor microenvironment.

Cancer Lett 2016 09 4;380(1):272-80. Epub 2015 Nov 4.

Department of Experimental and Clinical Biomedical Sciences, University of Florence, 50134 Florence, Italy.

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http://dx.doi.org/10.1016/j.canlet.2015.10.027DOI Listing
September 2016

Etoposide-Bevacizumab a new strategy against human melanoma cells expressing stem-like traits.

Oncotarget 2016 Aug;7(32):51138-51149

Department of Experimental and Clinical Biomedical Sciences, University of Florence, 50134, Florence, Italy.

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http://dx.doi.org/10.18632/oncotarget.9939DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5239464PMC
August 2016

β3-adrenoreceptor and tumor microenvironment: a new hub.

Oncoimmunology 2015 Nov 2;4(11):e1026532. Epub 2015 Apr 2.

Neonatal Intensive Care Unit; Medical Surgical Fetal-Neonatal Department; A. Meyer University Children's Hospital ; Florence, Italy.

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http://dx.doi.org/10.1080/2162402X.2015.1026532DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4589043PMC
November 2015

Cancer stemness and progression: mitochondria on the stage.

Oncotarget 2015 Nov;6(35):36924-5

Department of Experimental and Clinical Biomedical Sciences, Università degli Studi di Firenze, Florence, Italy.

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http://dx.doi.org/10.18632/oncotarget.6244DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741904PMC
November 2015

Norepinephrine promotes tumor microenvironment reactivity through β3-adrenoreceptors during melanoma progression.

Oncotarget 2015 Mar;6(7):4615-32

Department of Experimental and Clinical Biomedical Sciences, University of Florence, Tuscany Tumor Institute and "Center for Research, Transfer and High Education DenoTHE", Florence, Italy.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4467103PMC
http://dx.doi.org/10.18632/oncotarget.2652DOI Listing
March 2015

Senescent stroma promotes prostate cancer progression: the role of miR-210.

Mol Oncol 2014 Dec 21;8(8):1729-46. Epub 2014 Jul 21.

Department of Experimental and Clinical Biomedical Sciences, University of Florence, Viale Morgagni 50, 50134 Florence, Italy; Center for Research, Transfer and High Education 'Study at Molecular and Clinical Level of Chronic, Inflammatory, Degenerative and Neoplastic Disorders for the Development on Novel Therapies', Italy.

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http://ac.els-cdn.com/S1574789114001641/1-s2.0-S157478911400
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http://linkinghub.elsevier.com/retrieve/pii/S157478911400164
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http://dx.doi.org/10.1016/j.molonc.2014.07.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5528604PMC
December 2014

Redox circuitries driving Src regulation.

Antioxid Redox Signal 2014 May 20;20(13):2011-25. Epub 2013 Sep 20.

1 Department of Experimental and Clinical Biomedical Sciences, University of Florence , Florence, Italy .

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http://dx.doi.org/10.1089/ars.2013.5525DOI Listing
May 2014

Mesenchymal to amoeboid transition is associated with stem-like features of melanoma cells.

Cell Commun Signal 2014 Apr 1;12:24. Epub 2014 Apr 1.

Department of Experimental and Clinical Biomedical Sciences, Tuscany Tumor Institute, University of Florence, viale Morgagni 50, Florence 50134, Italy.

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http://dx.doi.org/10.1186/1478-811X-12-24DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4022383PMC
April 2014

Tumor microenvironment and metabolism in prostate cancer.

Semin Oncol 2014 Apr 5;41(2):267-80. Epub 2014 Mar 5.

Dipartimento di Scienze Biomediche Sperimentali e Cliniche, University of Florence, Tuscany Tumor Institute, viale Morgagni 50, 50134 Florence, Italy.

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http://dx.doi.org/10.1053/j.seminoncol.2014.03.004DOI Listing
April 2014

miR-205 hinders the malignant interplay between prostate cancer cells and associated fibroblasts.

Antioxid Redox Signal 2014 Mar 17;20(7):1045-59. Epub 2013 Sep 17.

1 Department of Experimental Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori , Milan, Italy .

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http://dx.doi.org/10.1089/ars.2013.5292DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3929333PMC
March 2014

Tumor-stroma metabolic relationship based on lactate shuttle can sustain prostate cancer progression.

BMC Cancer 2014 Mar 5;14:154. Epub 2014 Mar 5.

Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, Via Vetoio, Coppito 2, 67100 L'Aquila, Italy.

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http://dx.doi.org/10.1186/1471-2407-14-154DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3945608PMC
March 2014

Metabolic implication of tumor:stroma crosstalk in breast cancer.

J Mol Med (Berl) 2014 Feb 24;92(2):117-26. Epub 2014 Jan 24.

Department of Experimental and Clinical Biomedical Sciences, University of Florence, viale GB Morgagni 50, Florence, I-50134, Italy.

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http://dx.doi.org/10.1007/s00109-014-1124-7DOI Listing
February 2014

Anoikis molecular pathways and its role in cancer progression.

Biochim Biophys Acta 2013 Dec 2;1833(12):3481-3498. Epub 2013 Jul 2.

Department of Experimental and Clinical Biomedical Sciences, University of Florence, 50134 Florence, Italy; Tuscany Tumor Institute and "Center for Research, Transfer and High Education, DENOTHE", 50134 Florence, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.bbamcr.2013.06.026DOI Listing
December 2013

Tumor microenvironment: bone marrow-mesenchymal stem cells as key players.

Biochim Biophys Acta 2013 Dec 29;1836(2):321-35. Epub 2013 Oct 29.

Department of Experimental and Clinical Biomedical Sciences, University of Florence, Tuscany Tumor Institute and Center for Research, Transfer and High Education DenoTHE, Florence, Italy; CAPES Foundation, Ministry of Education of Brazil, Brasília, DF, Brazil. Electronic address:

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http://dx.doi.org/10.1016/j.bbcan.2013.10.004DOI Listing
December 2013

Redox molecular machines involved in tumor progression.

Antioxid Redox Signal 2013 Nov 8;19(15):1828-45. Epub 2013 Jan 8.

1 Department of Biochemical Science, University of Florence , Florence, Italy .

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http://dx.doi.org/10.1089/ars.2012.5040DOI Listing
November 2013

Microenvironment and tumor cell plasticity: an easy way out.

Cancer Lett 2013 Nov 31;341(1):80-96. Epub 2013 Jan 31.

Department of Biochemical Sciences, University of Florence, Viale Morgagni 50, 50134 Firenze, Italy.

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https://linkinghub.elsevier.com/retrieve/pii/S03043835130008
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http://dx.doi.org/10.1016/j.canlet.2013.01.042DOI Listing
November 2013

The effects of CA IX catalysis products within tumor microenvironment.

Cell Commun Signal 2013 Oct 29;11:81. Epub 2013 Oct 29.

Dipartimento di Scienze Biomediche Sperimentali e Cliniche, Università degli Studi di Firenze, Viale Morgagni 50, 50134 Firenze, Italy.

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http://link.springer.com/content/pdf/10.1186%2F1478-811X-11-
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http://biosignaling.biomedcentral.com/articles/10.1186/1478-
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http://dx.doi.org/10.1186/1478-811X-11-81DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3874735PMC
October 2013

Cancer-associated fibroblasts and macrophages: Friendly conspirators for malignancy.

Authors:
Paola Chiarugi

Oncoimmunology 2013 Sep 3;2(9):e25563. Epub 2013 Jul 3.

Department of Experimental and Clinical Biomedical Sciences; Tuscany Tumor Institute; University of Florence; Florence, Italy ; "Center for Research, Transfer and High Education DenoTHE"; Florence, Italy.

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http://dx.doi.org/10.4161/onci.25563DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3850271PMC
September 2013

Multivalent presentation of a hydrolytically stable GM(3) lactone mimetic as modulator of melanoma cells motility and adhesion.

Bioorg Med Chem 2013 May 24;21(10):2756-63. Epub 2013 Mar 24.

Department of Chemistry, University of Florence, via della Lastruccia 3, 13 50019 Sesto F. no, FI, Italy.

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http://dx.doi.org/10.1016/j.bmc.2013.03.021DOI Listing
May 2013

Chronic resveratrol treatment ameliorates cell adhesion and mitigates the inflammatory phenotype in senescent human fibroblasts.

J Gerontol A Biol Sci Med Sci 2013 Apr 29;68(4):371-81. Epub 2012 Aug 29.

Department of Preclinical and Clinical Pharmacology, University of Florence, Italy.

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http://dx.doi.org/10.1093/gerona/gls183DOI Listing
April 2013

β-adrenoceptors are upregulated in human melanoma and their activation releases pro-tumorigenic cytokines and metalloproteases in melanoma cell lines.

Lab Invest 2013 Mar 14;93(3):279-90. Epub 2013 Jan 14.

Section of Clinical, Preventive and Oncologic Dermatology, Department of Surgery and Translational Medicine, University of Florence, Florence, Italy.

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http://dx.doi.org/10.1038/labinvest.2012.175DOI Listing
March 2013

Tumors and their stroma: mitochondria at the crossroad.

Cell Cycle 2013 Jan 15;12(2):204-5. Epub 2012 Jan 15.

Department of Biochemical Sciences, University of Florence, Florence, Italy.

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http://dx.doi.org/10.4161/cc.23421DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3575448PMC
January 2013

22 : 6n-3 DHA inhibits differentiation of prostate fibroblasts into myofibroblasts and tumorigenesis.

Br J Nutr 2012 Dec 6;108(12):2129-37. Epub 2012 Mar 6.

Department of Experimental Pathology and Oncology, University of Florence, Viale G.B. Morgagni 50, 50134 Florence, Italy.

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http://dx.doi.org/10.1017/S0007114512000359DOI Listing
December 2012

Stromal fibroblasts synergize with hypoxic oxidative stress to enhance melanoma aggressiveness.

Cancer Lett 2012 Nov 1;324(1):31-41. Epub 2012 Jun 1.

Department of Biochemical Sciences, University of Florence, Tuscany Tumor Institute and Center for Research, Transfer and High Education DenoTHE, 50134 Florence, Italy.

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http://dx.doi.org/10.1016/j.canlet.2012.04.025DOI Listing
November 2012

Reciprocal metabolic reprogramming through lactate shuttle coordinately influences tumor-stroma interplay.

Cancer Res 2012 Oct 31;72(19):5130-40. Epub 2012 Jul 31.

Department of Biochemical Sciences, Tuscany Tumor Institute and Center for Research, Transfer and High Education DenoTHE, University of Florence, Florence, Italy.

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http://dx.doi.org/10.1158/0008-5472.CAN-12-1949DOI Listing
October 2012

Redox Regulation of Nonmuscle Myosin Heavy Chain during Integrin Engagement.

J Signal Transduct 2012 19;2012:754964. Epub 2011 Dec 19.

Department of Biochemical Sciences, University of Florence, Viale Morgagni 50, 50134 Florence, Italy.

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http://dx.doi.org/10.1155/2012/754964DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3246775PMC
August 2012

Mitochondrial Oxidative Stress due to Complex I Dysfunction Promotes Fibroblast Activation and Melanoma Cell Invasiveness.

J Signal Transduct 2012 4;2012:684592. Epub 2012 Jan 4.

Department of Biochemical Sciences, Tuscany Tumor Institute, University of Florence, Morgagni Avenue 50, 50134 Florence, Italy.

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http://dx.doi.org/10.1155/2012/684592DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3261495PMC
August 2012

Reactive oxygen species: friends and foes of signal transduction.

J Signal Transduct 2012 11;2012:534029. Epub 2012 Mar 11.

Department of Clinical and Biological Sciences, University of Turin, Regione Gonzole 10, 10043 Orbassano, Italy.

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http://dx.doi.org/10.1155/2012/534029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3317100PMC
August 2012

Oxidative stress, tumor microenvironment, and metabolic reprogramming: a diabolic liaison.

Int J Cell Biol 2012 13;2012:762825. Epub 2012 May 13.

Department of Biochemical Sciences, University of Florence, 50134 Florence, Italy.

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http://dx.doi.org/10.1155/2012/762825DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3361160PMC
August 2012

EMT and oxidative stress: a bidirectional interplay affecting tumor malignancy.

Antioxid Redox Signal 2012 Jun 2;16(11):1248-63. Epub 2011 Nov 2.

Department of Biochemical Sciences, University of Florence, Tuscany Tumor Institute, and Center for Research, Transfer and High Education DenoTHE, Florence, Italy.

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http://dx.doi.org/10.1089/ars.2011.4280DOI Listing
June 2012

Cancer-associated-fibroblasts and tumour cells: a diabolic liaison driving cancer progression.

Cancer Metastasis Rev 2012 Jun;31(1-2):195-208

Department of Biochemical Science, University of Florence, Florence, Italy.

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http://dx.doi.org/10.1007/s10555-011-9340-xDOI Listing
June 2012

Inflammatory response in human skeletal muscle cells: CXCL10 as a potential therapeutic target.

Eur J Cell Biol 2012 Feb 15;91(2):139-49. Epub 2011 Dec 15.

Department of Health Sciences, University of Rome Foro Italico, 00135 Rome, Italy.

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http://dx.doi.org/10.1016/j.ejcb.2011.09.011DOI Listing
February 2012

Cancer associated fibroblasts: the dark side of the coin.

Am J Cancer Res 2011 12;1(4):482-97. Epub 2011 Mar 12.

Department of Biochemical Science, University of Florence viale Morgagni 50, 50134 Florence, Italy.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3186047PMC
November 2011

HIF-1α stabilization by mitochondrial ROS promotes Met-dependent invasive growth and vasculogenic mimicry in melanoma cells.

Free Radic Biol Med 2011 Aug 12;51(4):893-904. Epub 2011 Jun 12.

Department of Biochemical Sciences, University of Florence, 50134 Firenze, Italy.

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http://dx.doi.org/10.1016/j.freeradbiomed.2011.05.042DOI Listing
August 2011

Cancer associated fibroblasts exploit reactive oxygen species through a proinflammatory signature leading to epithelial mesenchymal transition and stemness.

Antioxid Redox Signal 2011 Jun 28;14(12):2361-71. Epub 2011 Mar 28.

Department of Biochemical Sciences, University of Florence, Viale Morgagni 50, Florence, Italy.

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http://dx.doi.org/10.1089/ars.2010.3727DOI Listing
June 2011

EphA2 induces metastatic growth regulating amoeboid motility and clonogenic potential in prostate carcinoma cells.

Mol Cancer Res 2011 Feb 4;9(2):149-60. Epub 2011 Jan 4.

Department of Biochemical Sciences, University of Florence, Tuscany Tumor Institute, Florence, Italy.

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http://dx.doi.org/10.1158/1541-7786.MCR-10-0298DOI Listing
February 2011

Rac and Rho GTPases in cancer cell motility control.

Cell Commun Signal 2010 Sep 7;8:23. Epub 2010 Sep 7.

Department of Biochemical Sciences, University of Florence, Tuscany Tumor Institute and "Center for Research, Transfer and High Education DenoTHE", 50134 Florence, Italy.

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http://dx.doi.org/10.1186/1478-811X-8-23DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2941746PMC
September 2010

Escaping from, moving towards, following a path, squeezing through: lots of opportunities for moving cells.

Authors:
Paola Chiarugi

Cell Commun Signal 2010 Sep 7;8:25. Epub 2010 Sep 7.

Department of Biochemical Sciences, University of Florence, Tuscany Tumor Institute and "Center for Research, Transfer and High Education DenoTHE", Viale Morgagni 50, 50134 Firenze, Italy.

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http://biosignaling.biomedcentral.com/articles/10.1186/1478-
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http://dx.doi.org/10.1186/1478-811X-8-25DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2942891PMC
September 2010

Src redox regulation: again in the front line.

Free Radic Biol Med 2010 Aug 29;49(4):516-27. Epub 2010 Apr 29.

Department of Biochemical Sciences, Tuscany Tumor Institute, and Center for Research, Transfer, and High Education DenoTHE, University of Florence, 50134 Florence, Italy.

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http://dx.doi.org/10.1016/j.freeradbiomed.2010.04.025DOI Listing
August 2010

Metastasis: cancer cell's escape from oxidative stress.

Cancer Metastasis Rev 2010 Jun;29(2):351-78

Institute of General Pathology, Catholic University Medical School, Rome, Italy.

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http://dx.doi.org/10.1007/s10555-010-9225-4DOI Listing
June 2010

Adiponectin in health and diseases: from metabolic syndrome to tissue regeneration.

Expert Opin Ther Targets 2010 Feb;14(2):193-206

University of Florence, Department of Biochemical Science, viale Morgagni 50, 50134 Firenze, Italy.

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http://www.tandfonline.com/doi/full/10.1517/1472822090353071
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http://dx.doi.org/10.1517/14728220903530712DOI Listing
February 2010

Survival or death: the redox paradox.

Authors:
Paola Chiarugi

Antioxid Redox Signal 2009 Nov;11(11):2651-4

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http://dx.doi.org/10.1089/ars.2009.2770DOI Listing
November 2009

Redox-based escape mechanism from death: the cancer lesson.

Antioxid Redox Signal 2009 Nov;11(11):2791-806

Institute of General Pathology, Catholic University Medical School , Rome, Italy.

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http://dx.doi.org/10.1089/ars.2009.2739DOI Listing
November 2009

Sphingosine 1-phosphate increases glucose uptake through trans-activation of insulin receptor.

Cell Mol Life Sci 2009 Oct 7;66(19):3207-18. Epub 2009 Aug 7.

Department of Biochemical Sciences, University of Florence, Viale G.B. Morgagni 50, 50134, Florence, Italy.

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http://dx.doi.org/10.1007/s00018-009-0106-3DOI Listing
October 2009

Redox regulation of ephrin/integrin cross-talk.

Cell Adh Migr 2007 Jan-Mar;1(1):33-42. Epub 2007 Jan 29.

Department of Biochemical Sciences, University of Florence, Florence, Italy.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2633678PMC
June 2009

Globular adiponectin induces differentiation and fusion of skeletal muscle cells.

Cell Res 2009 May;19(5):584-97

Department of Biochemical Sciences, University of Florence, V.le Morgagni 50, 50134 Florence, Italy.

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http://www.nature.com/articles/cr200939
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http://dx.doi.org/10.1038/cr.2009.39DOI Listing
May 2009

EphA2 reexpression prompts invasion of melanoma cells shifting from mesenchymal to amoeboid-like motility style.

Cancer Res 2009 Mar 24;69(5):2072-81. Epub 2009 Feb 24.

Department of Biochemical Sciences, University of Florence, Center for Research, Transfer and High Education Study, Italy.

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http://dx.doi.org/10.1158/0008-5472.CAN-08-1845DOI Listing
March 2009

Anoikis: a necessary death program for anchorage-dependent cells.

Biochem Pharmacol 2008 Dec 25;76(11):1352-64. Epub 2008 Jul 25.

Department of Biochemical Sciences, University of Florence, Italy.

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http://dx.doi.org/10.1016/j.bcp.2008.07.023DOI Listing
December 2008

Src redox regulation: there is more than meets the eye.

Authors:
Paola Chiarugi

Mol Cells 2008 Oct 5;26(4):329-37. Epub 2008 Sep 5.

Department of Biochemical Sciences, University of Florence, Centre for Research, Transfer and High Education Study at Molecular and Clinical Level of Chronic Disorders for the Development on Novel Therapies, Firenze, Italy.

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October 2008

From anchorage dependent proliferation to survival: lessons from redox signalling.

Authors:
Paola Chiarugi

IUBMB Life 2008 May;60(5):301-7

Department of Biochemical Sciences, University of Florence, Italy.

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http://dx.doi.org/10.1002/iub.45DOI Listing
May 2008

Dual role of mitochondrial reactive oxygen species in hypoxia signaling: activation of nuclear factor-{kappa}B via c-SRC and oxidant-dependent cell death.

Cancer Res 2007 Aug;67(15):7368-77

Liver Unit, Centro de Investigaciones Biomédicas Esther Koplowitz, Instituto de Malalties Digestives, Hospital Clinic I Provincial and CIBEREHD, Instituto Salud Carlos III, University of Barcelona, Barcelona, Spain.

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http://dx.doi.org/10.1158/0008-5472.CAN-07-0515DOI Listing
August 2007

EphrinA1 activates a Src/focal adhesion kinase-mediated motility response leading to rho-dependent actino/myosin contractility.

J Biol Chem 2007 Jul 22;282(27):19619-28. Epub 2007 Apr 22.

Department of Biochemical Sciences, University of Florence, Viale Morgagni 50, 50134 Florence, Italy.

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http://dx.doi.org/10.1074/jbc.M701319200DOI Listing
July 2007

Redox-dependent and ligand-independent trans-activation of insulin receptor by globular adiponectin.

Hepatology 2007 Jul;46(1):130-9

Department of Biochemical Sciences, University of Florence, Florence, Italy.

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http://dx.doi.org/10.1002/hep.21643DOI Listing
July 2007

Redox signalling in anchorage-dependent cell growth.

Cell Signal 2007 Apr 28;19(4):672-82. Epub 2006 Nov 28.

Department of Biochemical Sciences, University of Florence, Italy.

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http://linkinghub.elsevier.com/retrieve/pii/S089865680600305
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http://dx.doi.org/10.1016/j.cellsig.2006.11.009DOI Listing
April 2007

Integrin-mediated cell adhesion and spreading engage different sources of reactive oxygen species.

Antioxid Redox Signal 2007 Apr;9(4):469-81

Department of Biochemical Sciences, University of Florence, Florence, Italy.

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http://dx.doi.org/10.1089/ars.2006.1392DOI Listing
April 2007

Protein tyrosine phosphorylation and reversible oxidation: two cross-talking posttranslation modifications.

Antioxid Redox Signal 2007 Jan;9(1):1-24

Department of Biochemical Sciences, University of Florence Center for Research, Transfer and High Education, Florence, Italy.

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http://www.liebertpub.com/doi/10.1089/ars.2007.9.1
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http://dx.doi.org/10.1089/ars.2007.9.1DOI Listing
January 2007

A novel redox-based switch: LMW-PTP oxidation enhances Grb2 binding and leads to ERK activation.

Biochem Biophys Res Commun 2006 Sep 28;348(2):367-73. Epub 2006 Jul 28.

Department of Biochemical Sciences, University of Florence, Viale Morgagni 50, 50134 Florence, Italy.

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http://dx.doi.org/10.1016/j.bbrc.2006.07.091DOI Listing
September 2006

Redox regulation of beta-actin during integrin-mediated cell adhesion.

J Biol Chem 2006 Aug 5;281(32):22983-91. Epub 2006 Jun 5.

Department of Biochemical Sciences, Center of Excellence for Scientific Research DENOTHE, Department of Anatomy, University of Florence, Italy.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M603040200
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August 2006

During muscle ageing the activation of the mitogenic signalling is not sufficient to guarantee cellular duplication.

Ital J Biochem 2005 Sep-Dec;54(3-4):258-67

Dipartimento di Scienze Biochimiche, Università di Firenze, viale Morgagni 50, 50134 Firenze, Italia.

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June 2006

Oxidation and inactivation of low molecular weight protein tyrosine phosphatase by the anticancer drug Aplidin.

Int J Cancer 2006 Apr;118(8):2082-8

Department of Biochemical Sciences, University of Florence, viale Morgagni 50, 50134 Florence, Italy.

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http://dx.doi.org/10.1002/ijc.21602DOI Listing
April 2006