Dr.  Panagiotis Paliogiannis, MD, PhD - University of Sassari - Department of Medical, Surgical and Experimental Sciences

Dr. Panagiotis Paliogiannis

MD, PhD

University of Sassari

Department of Medical, Surgical and Experimental Sciences

Sassari, Sardinia | Italy

Main Specialties: Chemical Pathology, Molecular Genetic Pathology, Surgery

Additional Specialties: Clinical Pathology, Surgery

ORCID logohttps://orcid.org/0000-0001-5485-6056

Dr.  Panagiotis Paliogiannis, MD, PhD - University of Sassari - Department of Medical, Surgical and Experimental Sciences

Dr. Panagiotis Paliogiannis

MD, PhD

Introduction

Primary Affiliation: University of Sassari - Sassari, Sardinia , Italy

Specialties:

Additional Specialties:

Research Interests:

Publications

140Publications

1215Reads

433Profile Views

81PubMed Central Citations

Mean Platelet Volume, Red Cell Distribution Width, and Complete Blood Cell Count Indices in Retinal Vein Occlusions.

Ophthalmic epidemiology

PURPOSE:To evaluate the role of some complete blood cell count (CBC)-derived measures in retinal vein occlusion (RVO). METHODS:This was a retrospective case-control study, including 127 newly diagnosed RVO patients and 127 sex- and age-matched subjects without RVO. A blood sample was obtained and a complete blood cell count was performed. Neutrophil/lymphocyte ratio (NLR), derived NLR [dNLR = neutrophils/(white blood cells‒neutrophils)], and platelet/lymphocyte ratio (PLR) were calculated. We also performed a meta-analysis of the available data, ours included, on the correlation between mean platelet volume (MPV) and RVO. Standardized mean differences (SMD) were used to build forest plots and assess differences in MPV values between RVO patients and controls. RESULTS:Median MPV and red cell distribution width (RDW) were 8.7 fL (IQR = 7.8-9.5) and 13.2% (IQR = 12.4-14.2) in RVO patients and 7.8 fL (IQR = 7.1-8.5) and 13% (IQR = 12-14) in controls. RVO patients had significantly higher values of MPV (P < .0001) and RDW (P = .005). There were no significant differences between the values of white blood cells, lymphocytes, neutrophils, platelets, NLR, dNLR, and PLR. Multivariable logistic regression analysis revealed a statistically significant correlation between increased MPV and RVO (OR = 1.74, 95% CI = 1.38-2.2, P < .0001). 519 RVO patients and 414 controls from 6 case-control studies were included in the meta-analysis. Pooled results disclosed that MPV values were significantly higher in RVO patients (SMD = 0.41 fL, 95% CI = 0.04-0.79, P = .032), but extreme heterogeneity was observed (I2 = 86.1%, P < .001). CONCLUSION:Results suggest lack of association between CBC-derived inflammatory indices and RVO. Conversely, MPV and, to a lesser extent, RDW may be disease biomarkers in RVO.

https://doi.org/10.1080/09286586.2020.1791349

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July 2020

Resveratrol Inhibits Oxidative Stress and Prevents Mitochondrial Damage Induced by Zinc Oxide Nanoparticles in Zebrafish (Danio rerio)

International Journal of Molecular Sciences

Despite their wide industrial use, Zinc oxide (ZnO) nanoparticles (NPs) exhibit a high toxic potential while concerns of their health-related risks are still present, urging additional in vivo clarification studies. Oxidative stress is recognized as the primary trigger of NP-associated toxicity, suggesting antioxidants as a promising counteractive approach. Here, we investigated the protective effect of the natural antioxidant resveratrol against ZnO NP-induced toxicity in vivo using the zebrafish model. Our findings demonstrate that resveratrol counteracts ZnO NP-induced zebrafish lethality preventing cardiac morphological and functional damage. NP-induced vascular structural abnormalities during embryonic fish development were significantly counteracted by resveratrol treatment. Mechanistically, we further showed that resveratrol inhibits ROS increase, prevents mitochondrial membrane potential dysfunction, and counteracts cell apoptosis/necrosis elicited by ZnO NP. Overall, our data provide further evidence demonstrating the primary role of oxidative stress in NP-induced damage, and highlight new insights concerning the protective mechanism of antioxidants against nanomaterial toxicity.

http://dx.doi.org/10.3390/ijms21113838

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May 2020

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May 2020
1 Read

Role of the mTOR pathway in liver cancer: from molecular genetics to targeted therapies.

Hepatology (Baltimore, Md.)

Primary liver cancers, including hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (iCCA), are highly lethal and frequent tumors worldwide, with few effective treatment options. The mammalian target of Rapamycin (mTOR) complex is a central regulator of cell growth and metabolism by its ability to integrate inputs from amino acids, nutrients and extracellular signals. The mTOR protein is incorporated into two distinct complexes: mammalian target of Rapamycin complex 1 (mTORC1) and mammalian target of Rapamycin complex 2 (mTORC2). Specifically, mTORC1 regulates protein synthesis, glucose and lipid metabolism, and autophagy, whereas mTORC2 promotes liver tumorigenesis via modulating the AGC family of serine/threonine kinases, especially the AKT (protein kinase B) proteins. In human HCC and iCCA samples, genomics analyses have unraveled the frequent de-regulation of the mTOR complexes. Both in vitro and in vivo studies have demonstrated the key role of mTORC1 and mTORC2 in liver tumor development and progression. The first generation mTOR inhibitors have been evaluated for effectiveness in liver tumor treatment and provided unsatisfactory results. Current research efforts are devoted to generating more efficacious mTOR inhibitors and identify biomarkers for patient selection as well as for novel combination therapies. Here, we provide a comprehensive review of the mechanisms leading to deregulated mTOR signaling cascade in liver cancers, the mechanisms whereby the mTOR pathway contributes to HCC and iCCA molecular pathogenesis, the therapeutic strategies, and the challenges that we need to overcome to effectively inhibit mTOR in liver cancer treatment. In conclusion: Deregulated mTOR signaling significantly contributes to HCC and iCCA molecular pathogenesis. mTOR inhibitors, presumably administered in association with other drugs, might be effective against subsets of human liver tumors.

https://doi.org/10.1002/hep.31310

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May 2020
1 Read

Bilirubin levels in patients with mild and severe Covid-19: a pooled analysis.

In press

Liver International

The article comments on a recent commentary published in Liver International entitled “COVID-19 and liver disease” by Sun et al., and describes a pooled analysis of data on bilirubin levels in patients with and without severe Covid-19. This is the first pooled analysis of data on bilirubin in Covid-19 patients. The results evidence that bilirubin levels are significantly associated with the severity of the disease.

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April 2020
4 Reads

Blood cell count indexes as predictors of anastomotic leakage in elective colorectal surgery: a multicenter study on 1,432 patients.

18;89

World Journal of Surgical Oncology

Background. The aim of this study was to evaluate a series of blood count inflammation indexes in predicting anastomotic leakage (AL) in elective colorectal surgery. Methods. Demographic, pathologic and clinical data of 1,432 consecutive patients submitted to colorectal surgery in eight surgical centers were retrospectively evaluated. The neutrophil to lymphocyte (NLR), derived neutrophil to lymphocyte (dNLR), lymphocyte to monocyte (LMR), and platelet to lymphocyte (PLR) ratios were calculated before surgery and on the 1st and 4th postoperative days, in patients with or without AL. Results. There were 106 patients with AL (65 males, mean age 67.4 years). The NLR, dNLR, and PLR were significantly higher in patients with AL in comparison to those without, on both the 1st and 4th postoperative day, but significance was greater on the 4th postoperative day. An NLR cut-off value of 7.1 on this day showed the best area under the curve (AUC 0.744. 95% CI: 0.719-0.768) in predicting AL. Conclusions. Among the blood cell indexes of inflammation evaluated, NLR on the 4th postoperative day showed the best ability to predict AL. NLR is a low cost, easy to perform and widely available index, which might be potentially used in clinical practice as a predictor of AL in patients undergoing elective colorectal surgery. 

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April 2020
1 Read

KIT and PDGFRa mutational patterns in Sardinian patients with gastrointestinal stromal tumors.

Eur J Cancer Prev 2020 Mar 9. Epub 2020 Mar 9.

Department of Medical, Surgical and Experimental Sciences, University of Sassari, Sassari, Italy.

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http://dx.doi.org/10.1097/CEJ.0000000000000581DOI Listing
March 2020
3.031 Impact Factor

Radio-Pathological Correlations in Patients with Liver Metastases for Colorectal Cancer.

Dig Surg 2020 Mar 30:1-7. Epub 2020 Mar 30.

The Center of Liver Diseases, Sheba Medical Center, Tel Aviv, Israel.

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http://dx.doi.org/10.1159/000506105DOI Listing
March 2020
1.742 Impact Factor

Complete Blood Cell Count-Derived Inflammation Biomarkers in Men with Age-Related Macular Degeneration.

Ocul Immunol Inflamm 2019 28;27(6):932-936. Epub 2018 Jun 28.

Department of Biomedical Sciences, University of Sassari , Sassari , Italy.

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http://dx.doi.org/10.1080/09273948.2018.1485960DOI Listing
February 2020
7 Reads
1.440 Impact Factor

MALONDIALDEHYDE LEVELS IN PATIENTS WITH AGE-RELATED MACULAR DEGENERATION: A Systematic Review and Meta-analysis.

Retina 2020 Feb;40(2):195-203

Department of Biomedical Sciences, University of Sassari, Sassari, Italy.

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http://dx.doi.org/10.1097/IAE.0000000000002574DOI Listing
February 2020
3.243 Impact Factor

reconstruction with autologous graft in the treatment of secondary aortoenteric fistulas: A retrospective case series.

Ann Med Surg (Lond) 2020 Jan 6;49:53-56. Epub 2019 Dec 6.

Department of Medical, Surgical and Experimental Sciences, University of Sassari, 07100, Sassari, Italy.

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http://dx.doi.org/10.1016/j.amsu.2019.11.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6926104PMC
January 2020

Pathogenetic, Prognostic, and Therapeutic Role of Fatty Acid Synthase in Human Hepatocellular Carcinoma.

Front Oncol 2019 11;9:1412. Epub 2019 Dec 11.

Department of Medical, Surgical and Experimental Medicine, University of Sassari, Sassari, Italy.

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http://dx.doi.org/10.3389/fonc.2019.01412DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6927283PMC
December 2019

Cryoablation In The Management Of Breast Cancer: Evidence To Date.

Breast Cancer (Dove Med Press) 2019 10;11:283-292. Epub 2019 Oct 10.

Unit of General Surgery 2 - Clinica Chirurgica, Department of Medical, Surgical and Experimental Sciences, University of Sassari, Sassari, Italy.

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http://dx.doi.org/10.2147/BCTT.S197406DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6791835PMC
October 2019

Germline and somatic mutations in patients with multiple primary melanomas: a next generation sequencing study.

BMC Cancer 2019 Aug 5;19(1):772. Epub 2019 Aug 5.

Unit of Cancer Genetics, Institute of Biomolecular Chemistry (ICB), National Research Council (CNR), Traversa La Crucca 3, Baldinca Li Punti, 07100, Sassari, Italy.

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http://dx.doi.org/10.1186/s12885-019-5984-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6683413PMC
August 2019
3 Reads
3.362 Impact Factor

Mutational concordance between primary and metastatic melanoma: a next-generation sequencing approach.

J Transl Med 2019 08 28;17(1):289. Epub 2019 Aug 28.

Unit of Cancer Genetics, Institute of Biomolecular Chemistry, National Research Council, Traversa La Crucca 3, 07100, Sassari, Italy.

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http://dx.doi.org/10.1186/s12967-019-2039-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6712827PMC
August 2019
2 Reads
3.930 Impact Factor

Effect of statin treatment on circulating malondialdehyde concentrations: a systematic review and meta-analysis

Therapeutic Advances in Chronic Disease

Background: The effect of statins on oxidative stress markers, such as malondialdehyde (MDA), is still a matter of debate. We sought to address this issue by conducting a systematic review and meta-analysis of published data on the effect of statin treatment on systemic MDA concentrations.

Methods: A literature search was conducted on MEDLINE/PubMed, ISI Web of Sciences and Scopus. Data were pooled using a random-effects model.

Results: A total of 35 studies assessing MDA concentrations before and after statin treatment in 1512 participants (mean age 53.6 years, 48.7% males) were identified. Extreme between-study heterogeneity was observed (I2 = 96.0%, p < 0.001). Pooled standardized mean difference (SMD) showed a significant reduction in plasma MDA concentrations after treatment (SMD = −1.47 μmol/l, 95% confidence interval = −1.89 to −1.05 μmol/l; p < 0.001). Similarly, a subgroup analysis of 10 studies that also included a placebo group showed a significant reduction in plasma MDA concentrations with statins (−1.03 μmol/l, 95% confidence interval = −1.52 to −0.29 μmol/l; p = 0.036).

Conclusions: This systematic review and meta-analysis showed that statin treatment significantly reduces systemic MDA concentrations. However, the results should be interpreted with caution because of extreme between-study heterogeneity, which warrants further intervention studies.

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July 2019
13 Reads

A diethylpyrocarbonate-based derivatization method for the LC-MS/MS measurement of plasma arginine and its chemically related metabolites and analogs.

Clin Chim Acta 2019 May 5;492:29-36. Epub 2019 Feb 5.

Department of Biomedical Sciences, School of Medicine, University of Sassari, Sassari, Italy; Quality Control Unit, University Hospital of Sassari (AOU-SS), Sassari, Italy.

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http://dx.doi.org/10.1016/j.cca.2019.02.004DOI Listing
May 2019
6 Reads
2.824 Impact Factor

MALONDIALDEHYDE LEVELS IN PATIENTS WITH AGE-RELATED MACULAR DEGENERATION: A Systematic Review and Meta-analysis.

Retina 2019 May 23. Epub 2019 May 23.

Department of Biomedical Sciences, University of Sassari, Sassari, Italy.

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http://dx.doi.org/10.1097/IAE.0000000000002574DOI Listing
May 2019
4 Reads
3.243 Impact Factor

Meta-Analysis of Asymmetric Dimethylarginine Concentrations in Rheumatic Diseases.

Sci Rep 2019 04 1;9(1):5426. Epub 2019 Apr 1.

Dipartimento di Scienze Biomediche, Università degli Studi di Sassari, Sassari, Italy.

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http://dx.doi.org/10.1038/s41598-019-41994-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443686PMC
April 2019
4 Reads
5.078 Impact Factor

Associations between the neutrophil-to-lymphocyte and the platelet-to-lymphocyte ratios and the presence and severity of psoriasis: a systematic review and meta-analysis.

Clin Exp Med 2019 Feb 26;19(1):37-45. Epub 2018 Nov 26.

Department of Biomedical Sciences, University of Sassari, Viale San Pietro 43, 07100, Sassari, Italy.

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http://link.springer.com/10.1007/s10238-018-0538-x
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http://dx.doi.org/10.1007/s10238-018-0538-xDOI Listing
February 2019
33 Reads
2.824 Impact Factor

Targeted Therapies in Cholangiocarcinoma: Emerging Evidence from Clinical Trials.

Medicina (Kaunas) 2019 Feb 8;55(2). Epub 2019 Feb 8.

Department of Medical, Surgical, and Experimental Sciences, University of Sassari, Viale San Pietro 43, 07100 Sassari, Italy.

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http://dx.doi.org/10.3390/medicina55020042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6409688PMC
February 2019
9 Reads
0.508 Impact Factor

Meta-analysis of neutrophil-to-lymphocyte and platelet-to-lymphocyte ratio in rheumatoid arthritis.

Eur J Clin Invest 2019 Jan 6;49(1):e13037. Epub 2018 Nov 6.

Dipartimento di Scienze Biomediche, Università degli Studi di Sassari, Sassari, Italy.

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http://doi.wiley.com/10.1111/eci.13037
Publisher Site
http://dx.doi.org/10.1111/eci.13037DOI Listing
January 2019
16 Reads
2.734 Impact Factor

Circulating serotonin levels in COPD patients: a pilot study.

BMC Pulm Med 2018 Nov 8;18(1):167. Epub 2018 Nov 8.

Department of Biomedical Sciences, University of Sassari, Sassari, Italy.

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http://dx.doi.org/10.1186/s12890-018-0730-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225723PMC
November 2018
7 Reads
2.490 Impact Factor

Oxidative stress-linked biomarkers in idiopathic pulmonary fibrosis: a systematic review and meta-analysis.

Biomark Med 2018 10 7;12(10):1175-1184. Epub 2018 Sep 7.

Department of Biomedical Sciences, University of Sassari, Viale San Pietro 43, 07100, Sassari, Italy.

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http://dx.doi.org/10.2217/bmm-2018-0108DOI Listing
October 2018
9 Reads
2.860 Impact Factor

Systemic concentrations of asymmetric dimethylarginine (ADMA) in chronic obstructive pulmonary disease (COPD): state of the art.

Amino Acids 2018 Sep 27;50(9):1169-1176. Epub 2018 Jun 27.

Department of Biomedical Sciences, University of Sassari, Sassari, Italy.

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http://dx.doi.org/10.1007/s00726-018-2606-7DOI Listing
September 2018
11 Reads
3.293 Impact Factor

Blood cell count indexes as predictors of outcomes in advanced non-small-cell lung cancer patients treated with Nivolumab.

Cancer Immunol Immunother 2018 Sep 9;67(9):1349-1353. Epub 2018 Jun 9.

Department of Biomedical Sciences, University of Sassari, Viale San Pietro 43, 07100, Sassari, Italy.

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http://dx.doi.org/10.1007/s00262-018-2182-4DOI Listing
September 2018
13 Reads
3.941 Impact Factor

Re: Neutrophil-to-lymphocyte ratio predicts anastomotic dehiscence.

ANZ J Surg 2018 09;88(9):939

Department of Clinical, Surgical and Experimental Sciences, University of Sassari, Sassari, Italy.

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http://dx.doi.org/10.1111/ans.14767DOI Listing
September 2018
5 Reads
1.120 Impact Factor

Red cell distribution width and mean platelet volume as predictors of anastomotic dehiscence in colorectal surgery: a pilot multicenter case-match study.

An Ital Chir

Aim. One of the most serious complications in modern colorectal surgery is the occurrence of an anastomotic dehiscence. The aim of this study was to evaluate the role of preoperative red cell distribution width (RDW) and mean platelet volume (MPV) as predictors of anastomotic dehiscence in elective surgery for colorectal cancer. Materials and methods. Forty-two patients with a clinically manifested anastomotic dehiscence after oncological colorectal surgery, and 42 controls matched for age, sex, pathological stage and tumor localization were enrolled. Correlations between the preoperative RDW and MPV values and anastomotic dehiscence were investigated. Results. Both the median RDW value (14.4 % vs 13.1%; p=0.007) and the median MPV value (8.0 fL vs 7.5 fL; p=0.037) were significantly higher in patients with anastomotic dehiscence than in those without. In multiple regression analysis only the RDW remained significantly associated with anastomotic dehiscence. Conclusions. The preoperative values of RDW may be useful in predicting anastomotic damage in elective oncological surgery.

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September 2018
12 Reads

Homoarginine and all-cause mortality: A systematic review and meta-analysis.

Eur J Clin Invest 2018 Aug 14;48(8):e12960. Epub 2018 Jun 14.

Department of Clinical Pharmacology, College of Medicine and Public Health, Flinders University and Flinders Medical Centre, Adelaide, Australia.

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http://dx.doi.org/10.1111/eci.12960DOI Listing
August 2018
7 Reads
2.734 Impact Factor

The neutrophil-to-lymphocyte ratio as a marker of chronic obstructive pulmonary disease and its exacerbations: A systematic review and meta-analysis.

Eur J Clin Invest 2018 Aug 5;48(8):e12984. Epub 2018 Jul 5.

Department of Biomedical Sciences, University of Sassari, Sassari, Italy.

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http://dx.doi.org/10.1111/eci.12984DOI Listing
August 2018
11 Reads
2.734 Impact Factor

Coronary flow reserve in systemic rheumatic diseases: a systematic review and meta-analysis.

Rheumatol Int 2018 07 7;38(7):1179-1190. Epub 2018 May 7.

Dipartimento di Scienze Biomediche, Università degli Studi di Sassari, Sassari, Italy.

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http://dx.doi.org/10.1007/s00296-018-4039-8DOI Listing
July 2018
7 Reads
1.630 Impact Factor

Circulating malondialdehyde concentrations in patients with stable chronic obstructive pulmonary disease: a systematic review and meta-analysis.

Biomark Med 2018 07 5;12(7):771-781. Epub 2018 Jun 5.

Department of Biomedical Sciences - University of Sassari, Sassari, Italy.

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http://dx.doi.org/10.2217/bmm-2017-0420DOI Listing
July 2018
9 Reads
2.860 Impact Factor

Mastectomy patterns, but not rates, are changing in the treatment of early breast cancer. Experience of a single European institution on 2315 consecutive patients.

Breast 2018 Jun 7;39:1-7. Epub 2018 Mar 7.

Unit of General Surgery 2-Clinica Chirurgica, Department of Clinical and Experimental Medicine, University of Sassari, Sassari, Italy.

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http://dx.doi.org/10.1016/j.breast.2018.02.003DOI Listing
June 2018
10 Reads
2.381 Impact Factor

Inflammatory cell indexes as preoperative predictors of hospital stay in open elective thoracic surgery.

ANZ J Surg 2018 Jun 24;88(6):616-620. Epub 2018 Apr 24.

Department of Biomedical Sciences, University of Sassari, Sassari, Italy.

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http://dx.doi.org/10.1111/ans.14557DOI Listing
June 2018
7 Reads
1.120 Impact Factor

A liquid chromatography-mass spectrometry study on the spirocyclization of ninhydrin with the aminothiols.

Microchemical Journal

Ninhydrin reacts with some aminothiols to form spiranes adducts whose optical and chromatographic properties have proved to be useful for chiral recognition. Liquid chromatography-mass spectrometry data along with spectroscopic analysis reveal that under certain conditions, in addition to the known single-spirane configuration, the spirothiazolidinic complexes can exist also as double- and mixed double-spiranes. The reaction was exploited to check the enantiomeric purity of two commercially available dosage form of D-penicillamine and to measure the aminothiol concentration in the urine sample from a subject under treatment with the drug. Separation of diastereoisomers was achieved on a C18 column in isocratic mode by using a mixture of an aqueous solution of formic acid (30 mmol/L)/acetonitrile (90:10, v/v) as a mobile phase. Diastereoisomers were detected by a fluorescence detector and mass spectrometer in short times and with a good resolution. Intra- and inter-assay reproducibility were under 4% with an average recovery of 98%. At a LOD of 0.01%, no evidence of the toxic distomer (l-enantiomer) was found in the biological sample and drugs.

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May 2018
15 Reads

Dermoscopy and confocal microscopy for metachronous multiple melanomas: morphological, clinical, and molecular correlations.

Eur J Dermatol 2018 Apr;28(2):149-156

Experimental Pathology and Oncology, Department of Clinical and Experimental Medicine, University of Sassari, Via Padre Manzella 4, 07100, Sassari, Italy, Skin Cancer Unit, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST), Meldola, FC, Italy.

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http://dx.doi.org/10.1684/ejd.2017.3206DOI Listing
April 2018
46 Reads
1.990 Impact Factor

Predictive Values of C-Reactive Protein and Neutrophil to Lymphocyte Ratio in Detecting Anastomotic Leak in Open Colorectal Surgery.

Dig Surg 2018 30;35(1):85. Epub 2017 Oct 30.

Departement of Biomedical Sciences, University of Sassari, Sassari, Italy.

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http://dx.doi.org/10.1159/000481415DOI Listing
April 2018
10 Reads
1.742 Impact Factor

Markers of oxidative stress, skeletal muscle mass and function, and their responses to resistance exercise training in older adults.

Exp Gerontol 2018 03 9;103:101-106. Epub 2018 Jan 9.

Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.exger.2017.12.024DOI Listing
March 2018
24 Reads
1 Citation
3.485 Impact Factor

Deciduoid mesothelioma of the thorax: A comprehensive review of the scientific literature.

Clin Respir J 2018 Mar 6;12(3):848-856. Epub 2017 Jan 6.

Pulmonology Clinic, Department of Clinical and Experimental Medicine, University of Sassari, Vle V.le San Pietro 43, Sassari 07100, Italy.

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http://dx.doi.org/10.1111/crj.12599DOI Listing
March 2018
38 Reads
2.200 Impact Factor

Neutrophil to lymphocyte ratio and clinical outcomes in COPD: recent evidence and future perspectives.

Eur Respir Rev 2018 Mar 7;27(147). Epub 2018 Feb 7.

Dept of Biomedical Sciences, University of Sassari, Sassari, Italy.

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http://dx.doi.org/10.1183/16000617.0113-2017DOI Listing
March 2018
9 Reads
2 Citations

Genetic alterations in main candidate genes during melanoma progression.

Oncotarget 2018 Feb 3;9(9):8531-8541. Epub 2018 Jan 3.

Unit of Cancer Genetics, Institute of Biomolecular Chemistry, National Research Council, Sassari, Italy.

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http://dx.doi.org/10.18632/oncotarget.23989DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5823576PMC
February 2018
41 Reads
6.360 Impact Factor

Spontaneous release of human serum albumin S-bound homocysteine in a thiol-free physiological medium.

International Journal of Peptide Research and Therapy

Elevated plasma homocysteine (Hcy) concentrations independently predict cardiovascular disease. However, the transport of Hcy into pathological tissues such as atherosclerotic plaques, characterized by relatively low local thiol concentrations, is largely unknown. We sought to address if albumin-bound Hcy can be released in a thiol-free medium with or without previous incubation with Hcy and homocysteine thiolactone (HTL). We found that Hcy release was dependent on the baseline amount of albumin-bound Hcy. After 48h incubation in a thiol- free medium the quantity of albumin-bound Hcy released from commercial human serum albumin (HSA) was 1.15 mmol/mol prot. If HSA was pre-incubated with 50 μmol/L reduced Hcy and then transferred into a free-thiol medium (HSA-S-Hcy), the amount of Hcy released after 48h increased to 33.5 mmol/mol prot. If HSA was pre-incubated with 5mmol/L HTL and then with 50 μmol/L of reduced Hcy (HSA-HTL-S-Hcy), the amount of Hcy released increased to 92.8 mmol/mol prot. Hcy release from HSA-HTL-S-Hcy further increased in presence of cysteine (Cys), glutathione (GSH), or Cys + GSH in the medium. Therefore, a significant amount of albumin bound Hcy is released into thiol-free environments, similar to atherosclerotic plaques, with potential deleterious effects on vascular homeostasis, atherosclerosis and thrombosis.

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December 2017
15 Reads

Pathophysiological roles, molecular interactions and clinical implications of long non-coding RNA CCAT2 in human cancer.

European Journal of Oncology

Less than 2% of human genome has protein-coding ability, while over 90 % is transcribed into non-coding RNA (ncRNA). NcRNA can be divided into small ncRNAs (<200 nucleotides) and long ncRNAs (>200 nucleotides). Small ncRNAs, including microRNAs (miRNAs), small interfering RNAs (siRNAs), and others have been investigated in recent years and recognized as key players in regulating cellular processes and diseases, including cancer. Long non-coding RNAs (lncRNAs) attracted increasing attention in recent years as researchers have revealed their crucial roles as regulators in embryogenesis, stem cell biology, and development. Furthermore, growing evidence indicates that dysregulation of lncRNAs is involved in cancer, and the regulatory functions and mechanisms of lncRNAs in human carcinomas have begun to emerge. Colon cancer-associated transcript 2 (CCAT2) is a lncRNA transcribed from human 8q24 gene desert, which has been recently found to be deregulated in several tumor types. In this review, we will briefly analyse the roles and mechanisms of lncRNAs CCAT2 involvement in human cancer, and we will discuss the future perspectives for research and clinical applications.

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December 2017
14 Reads

Vitamin D status and risk for malignant cutaneous melanoma: recent advances.

Eur J Cancer Prev 2017 11;26(6):532-541

aInstitute of Food Sciences, National Research Council (CNR), Avellino bDepartment of Surgical, Microsurgical and Medical Sciences, University of Sassari cInstitute of Biomolecular Chemistry, National Research Council (CNR), Cancer Genetics Unit, Sassari dRomagna Scientific Institute for the Study and Cure of Tumors, Skin Cancer Unit, Meldola, Italy.

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http://dx.doi.org/10.1097/CEJ.0000000000000334DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5627529PMC
November 2017
46 Reads
1 Citation
3.031 Impact Factor

Evaluation of global genomic DNA methylation in human whole blood by capillary electrophoresis UV detection.

J Anal Methods Chem

Alterations in global DNA methylation are implicated in various pathophysiological processes. The development of simple and quick, yet robust, methods to assess DNA methylation are required to facilitate its measurement and interpretation in clinical practice. We describe a highly sensitive and reproducible capillary electrophoresis method with UV detection for the separation and detection of cytosine and methylcytosine, after formic acid hydrolysis of DNA extracted from human whole blood. Hydrolysed samples were dried and re-suspended with water and directly injected into the capillary without sample derivatization procedures. The use of a run buffer containing 50 mmol/L of BIS-TRIS propane (BTP) phosphate buffer at pH 3.25 and 60 mmol/L sodium acetate buffer at pH 3.60 (4:1, v/v) allowed full analyte identification within 11 min. Precision tests indicated an elevated reproducibility with an inter-assay CV of 1.98% when starting from 2μg of extracted DNA. The method was successfully tested by measuring the DNA methylation degree both in healthy volunteers and in calf thymus reference DNA.

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November 2017
15 Reads

Desmoplastic small round cell tumors of the pleura: a review of the clinical literature.

Multidisciplinary Respiratory Medicine

Desmoplastic small round cell tumor of the pleura is a rare malignancy, with only a few cases reported in the scientific literature. The aim of the present review is to discuss the demographic, pathological, clinical, and therapeutic features of this rare tumor. English-language articles published since 1989 when the first case of desmoplastic small round cell tumor of the pleura was described were retrieved, and fifteen cases included in fourteen articles were revised. The mean age of the patients was 25.5 years, and 60% of them were males. Chest pain, pleural effusion and dyspnea were the most common clinical manifestations, while chest roentgenogram and computed tomography were the imaging techniques most commonly used. Surgical biopsy was employed in 80% of the cases for diagnosis. A multidisciplinary approach consisting in a combination of surgery with chemotherapy and radiation therapy was adopted in most cases. Only two patients (13.3%) were alive after 3 years from diagnosis, reflecting the aggressiveness of the disease, and the poor outcomes of the treatments currently available. Desmoplastic small round cell tumors of the pleura are extremely rare and challenging to diagnose, because of their rarity and unspecific demographic, clinical, and radiological features. An in-depth knowledge of such features is necessary for the optimal management of patients with this rare malignancy.

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August 2017
15 Reads

Epidemiology and genetic susceptibility of malignant melanoma in North Sardinia, Italy.

Eur J Cancer Prev 2017 05;26(3):263-267

aUnit of Pathology, Azienda Ospedaliero Universitaria (AOU) bUnit of Cancer Genetics, Institute of Biomolecular Chemistry, CNR cSassari Cancer Registry, Azienda Sanitaria Locale (ASL) n. 1 dSurgical Pathology Unit, AOU Sassari, Sassari, Italy.

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http://dx.doi.org/10.1097/CEJ.0000000000000223DOI Listing
May 2017
27 Reads
3 Citations
3.031 Impact Factor

Mutation analysis of mucosal and cutaneous melanomas during progression.

Journal of Clinical Oncology

Background: The prevalence of mutations in driver genes during progression in cutaneous and mucosal melanomas remains inconclusive. We investigated the prevalence and distribution of mutations in main candidate genes involved in melanomagenesis among different melanoma tissues using a next-generation sequencing (NGS) approach. Methods: Forty-eight tumor samples from 36 patients with mucosal melanoma (MM) and fifty-two tumor samples from 34 patients with cutaneous melanoma (CM) were collected, after obtaining patients’ written informed consent for tissue sampling. Genomic DNA was isolated from macrodissected tumor tissues containing at least 80% neoplastic cells and analyzed for mutations in 25 most common melanoma-associated oncogenes and tumor suppressor genes, using the IMI Diagnostic Melanoma Panel on the Ion Torrent platform (Life Technologies, USA). Results: A total of 100 tumor tissues from 70 melanoma patients were analyzed. BRAF mutations were detected in 21/34 (62%) CM patients and 13/36 (36%) mm patients. The second most prevalent mutations were found in K-/N-RAS (6/34; 18%) and cKIT (6/36; 17%) genes among CM and mm patients, respectively. No concomitant mutations of BRAF, RAS, and cKIT genes were detected. Among others, mutations were more frequently found in CCND1 (20%), ARID2 (16%), and NF1(12%) genes, considering the entire series of patients. Vast majority of patients who had paired samples of primary and secondary melanomas showed consistent mutation patterns between primary tumors and metastatic lesions. Similar frequencies of mutations in driver genes were seen across metastatic sites. Conclusions: In the era of targeted therapies, assessment of the spectrum and distribution of mutations in main molecular targets among patients with melanoma is needed. Our findings about the prevalence of mutations in driver genes in paired tumor lesions from patients with cutaneous and mucosal melanoma may be useful in the management of such diseases. The Italian Melanoma Intergroup (IMI) includes the following additional members who participated as investigators in this study: Mario Mandalà, Paola Queirolo, Ignazio Stanganelli, Vanna Chiarion Sileni, Pietro Quaglino, Anna Maria Di Giacomo.

http://dx.doi.org/10.1200/jco.2017.35.15_suppl.e21047

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May 2017
1 Read

Wirsung duct occlusion versus pancreaticojejunostomy after pancreaticoduodenectomy.

4:054

Inter J Surg Res and Pract

Background: Postoperative pancreatic fistula is still a cause of major morbidity after pancreaticoduodenectomy. The optimal management of the pancreatic remnant is still controversial. Our aim was to analyze the role of two different procedures in the management of pancreatic stump in a single surgical unit. Methods: We report our experience on 40 consecutive patients who underwent pancreaticoduodenectomy over a 6-year period and compare results between occlusion of the pancreatic duct and pancreaticojejunostomy. Results: A total of 40 patients who underwent pancreaticoduodenectomy were included in the study, 20 with a pancreaticojejunostomy and 20 with chemical occlusion of the pancreatic duct. Patient’s characteristics, operative and recovery data were similar between groups. The most frequent postoperative complication was pancreatic fistula; although incidence rate was higher in the duct occlusion group the difference was not statistically significant. Conclusions: There is no agreement on the optimal approach to the pancreatic stump after pancreaticoduodenectomy. Pancreaticojejunostomy is still the procedure of choice but further large randomized trials are needed to compare different methods of pancreatic remnant management. Nevertheless, it seems wise for pancreatic surgeons as well as general surgeons to be able to perform more than one technique

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May 2017
22 Reads

Perivascular Epithelioid Cell Tumors (PEComas) of the Orbit.

J Pathol Transl Med 2017 Jan 5;51(1):7-8. Epub 2017 Jan 5.

Department of Surgical, Microsurgical and Medical Sciences, University of Sassari, Sassari, Italy.

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http://dx.doi.org/10.4132/jptm.2016.10.26DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5267545PMC
January 2017
8 Reads
1 Citation

Long non-coding RNA CASC2 in human cancer.

Critical Reviews in Oncology/Hematology

Long non-coding RNAs cover large part of the non-coding information of the human DNA, which represents more than 90% of the whole genome. They constitute a wide and complex group of molecules with more than 200 nucleotides, which generally lack an open reading frame, and are involved in various ways in the pathophysiology of cancer. Their roles in the regulation of gene expression, imprinting, transcription, and post-translational processing have been described in several types of cancer. CASC2 was discovered in 2004 in patients with endometrial carcinoma as a potential tumor suppressor. Since then, additional studies in other types of neoplasia have been carried out, and both mechanisms and interactions of CASC2 in cancer have been better elucidated. In this review, we summarize the current knowledge on the role of CASC2 in the genesis, progression, and clinical management of human cancer.

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January 2017
20 Reads

Female adnexal tumors of probable Wolffian origin (FATWO): a case series with next-generation sequencing mutation analysis.

In press

International Journal of gynecological Pathology

Female adnexal tumours of probable wolffian origin (FATWO) are rare gynecological tumours with less than 90 cases reported in the current scientific literature. Their clinical features have been extensively described; less is known about the pathophysiological mechanisms and the molecular alterations underlying their development and growth. We performed a complete histopathological examination and a systematic mutation analysis using a next-generation sequencing (NGS) approach on three FATWOs from the archives of our institution in order to detect possible genetic alterations, and explore their role in the development of these rare tumors. The three cases presented missense mutations in different genes belonging to distinct molecular pathways: CTNNB1 and MET mutations for the first case; PIK3CA for the second one; BRAF and CDKN2A for the third one. Two variants with unknown functional effect on the protein were found in KDR and TP53 genes. In conclusion, a genetic heterogeneity was found in our series. No constant involvement of the most common pathways involved in tumorigenesis was found; nevertheless further studies are necessary to confirm the results of this pilot study.

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October 2016
15 Reads

Thoracoscopic treatment of a broncho-esophageal fistula: A case report.

Int J Surg Case Rep 2016 21;28:74-77. Epub 2016 Sep 21.

Unit of General Surgery, Department of Clinical and Experimental Medicine, University of Sassari, Viale San Pietro 43, 07100, Sassari, Italy. Electronic address:

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5043393PMC
http://dx.doi.org/10.1016/j.ijscr.2016.09.013DOI Listing
September 2016
15 Reads
2 Citations

Nonfunctional paraganglioma of the head of the pancreas: a rare case report.

In press

Int J Surg Case Rep

Background. Paragangliomas are rare neoplasms that originate from the neural crest. They are malignant in approximately 10% of cases, with a 50% survival rate at 5 years from diagnosis. In most cases, manifestations of malignancy (such as metastasis) are lacking, and paragangliomas are considered benign lesions. Pancreatic paragangliomas are extremely rare, with only 31 cases described in the scientific literature to date. Case summary. Here we describe a case of a 55-year- old Caucasian male patient referred to our institution in September 2013 for lumbar pain lasting five months. The ultrasound and the CT scan revealed a 2.5cm solid nodule located in the uncinate process of the pancreas. On the basis of this evidence, the preoperative diagnosis was a pancreatic neuroendocrine tumor (NET), which was further confirmed by a subsequent In-Pentetreotide Scan examination. A pylorus-preserving duodenocephalopancreasectomy was performed. Pancreatic paraganglioma was the final pathological diagnosis. Rare localizations of paraganglioma are often discovered casually, during imaging examinations for other clinical reasons, as happened in the case of our patient. It appears evident that the preoperative diagnosis of pancreatic paragangliomas is extremely challenging. Surgery represents the cornerstone of the clinical management of these neoplasms, primarily for the need of a definitive diagnosis, which is difficult to assess preoperatively in most cases. Conclusions. Our strategy is the same as that adopted for the management of pancreatic NETs; the dimensional limit for a conservative resection is 2cm, while major resections (Whipple’s approach or distal pancreatectomy) should be employed in larger tumors, which are generally associated with a worse prognosis.

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September 2016
16 Reads

Breast Nodular Fasciitis: A Comprehensive Review.

Breast Care (Basel) 2016 Aug 11;11(4):270-274. Epub 2016 Aug 11.

O.U. of Surgery I (Surgical Pathology), A.O.U. Sassari, Sassari, Italy.

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http://dx.doi.org/10.1159/000448185DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5040882PMC
August 2016
32 Reads
1 Citation
0.911 Impact Factor

Impact of novel histopathological factors on the outcomes of liver surgery for colorectal cancer metastasis

European Journal of Surgical Oncology

Introduction: We evaluated the impacts of a series of novel histopathological factors on clinical-surgical outcomes and survival of patients who underwent surgery for colorectal cancer liver metastasis, with and without neoadjuvant chemotherapy. Materials and methods: A prospective database including 150 consecutive patients who underwent 183 hepatic resections for metastatic colorectal cancer was evaluated. Among them, 74 (49.3%) received neoadjuvant chemotherapy before surgery. The histopathological fac- tors studied were: a) microsatellitosis, b) type and pattern of tumour growth, c) nuclear grade and the number of mitoses/mm2, d) perile- sional pseudocapsule, e) intratumoural fibrosis, f) lesion cellularity, g) hypoxic-angiogenic perilesional growth pattern, and h) the tumour normal interface. Results: Three or more metastatic lesions, R1 resection margins, and <50% tumour necrosis were prognostic factors for a worse OS, but only the former was confirmed to be an independent prognostic factor in the multivariate analysis. Furthermore, tumour fibrosis <40% and cellularity >10% were predictive of a worse neoadjuvant therapy response, but these findings were not confirmed in the multivariate anal- ysis. Finally, tumour necrosis <50%, cellularity >10%, and TNI >5 mm were prognostic factors for a worse DFS and AS in the univariate but not in the multivariate analysis. Conclusions: Several factors seem to influence the outcomes of surgery for colorectal cancer liver metastasis, especially the number of the lesions, the margins of resection, the percentage of necrosis and fibrosis, as well as the cellularity and the TNI.

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February 2016
15 Reads

Spigelian hernia A series of cases and literature review.

Ann Ital Chir 2016;87:306-311

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January 2016
9 Reads
2 Citations
0.683 Impact Factor

Multiple Molecular Pathways in Melanomagenesis: Characterization of Therapeutic Targets.

Front Oncol 2015 10;5:183. Epub 2015 Aug 10.

Dipartimento di Scienze Chirurgiche, Microchirurgiche e Mediche, Università di Sassari , Sassari , Italy.

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http://dx.doi.org/10.3389/fonc.2015.00183DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4530319PMC
August 2015
17 Reads
12 Citations

Radiofrequency ablation in the management of advanced stage thymomas: a case report on a novel multidisciplinary therapeutic approach.

Case Rep Radiol 2014 10;2014:697480. Epub 2014 Dec 10.

Department of Radio-Oncology, Oncological Hospital of Cagliari, Via E. Jenner 1, 09100 Cagliari, Italy.

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http://dx.doi.org/10.1155/2014/697480DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4276356PMC
January 2015
9 Reads

Robotic left ventricular epicardial lead positioning

Multimedia manual of cardiothoracic surgery : MMCTS / European Association for Cardio-Thoracic Surgery

http://www.scopus.com/inward/record.url?eid=2-s2.0-84944872483&partnerID=MN8TOARS

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January 2015
14 Reads

mutational concordance between primary and metastatic colorectal adenocarcinoma.

Oncol Lett 2014 Oct 4;8(4):1422-1426. Epub 2014 Aug 4.

Institute of Biomolecular Chemistry, Cancer Genetics Unit, National Research Council, Sassari I-07040, Italy.

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http://dx.doi.org/10.3892/ol.2014.2411DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4156255PMC
October 2014
8 Reads
7 Citations
0.990 Impact Factor

Discrepant alterations in main candidate genes among multiple primary melanomas.

J Transl Med 2014 May 8;12:117. Epub 2014 May 8.

Unit of Cancer Genetics, Institute of Biomolecular Chemistry (ICB), National Research Council (CNR) - Traversa La Crucca 3, Baldinca Li Punti, 07100 Sassari, Italy.

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http://dx.doi.org/10.1186/1479-5876-12-117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4023698PMC
May 2014
39 Reads
6 Citations
3.930 Impact Factor

Immunoreactivity for Ca 125 and INI 1 loss of expression are useful markers in the diagnosis of vulvar proximal-type epithelioid sarcomas: report of two cases.

Eur J Gynaecol Oncol 2013 ;34(5):469-72

lnstitute of Biomolecular Chemistry, Cancer Genetics Unit, C.N.R., Sarsari, Sassari, Italy.

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April 2014
6 Reads
0.602 Impact Factor

Unexpected distribution of cKIT and BRAF mutations among southern Italian patients with sinonasal melanoma.

Dermatology 2013 29;226(3):279-84. Epub 2013 Jun 29.

Unit of Cancer Genetics, Institute of Biomolecular Chemistry, CNR, University of Sassari, Sassari, Italy.

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http://dx.doi.org/10.1159/000350683DOI Listing
April 2014
13 Reads
3 Citations
1.685 Impact Factor

A case of gross haematuria due to an ureteric-iliac artery fistula.

Ann Ital Chir 2013 Dec 23;84(ePub). Epub 2013 Dec 23.

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December 2013
9 Reads
0.683 Impact Factor

Basal cell carcinoma of the nipple-areola complex: report of a case and literature review.

Ann Ital Chir 2013 Sep 12;84(ePub). Epub 2013 Sep 12.

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September 2013
7 Reads
1 Citation
0.683 Impact Factor

Lung cancer epidemiology in North Sardinia, Italy.

Multidiscip Respir Med 2013 Jul 12;8(1):45. Epub 2013 Jul 12.

Institute of Biomolecular Chemistry, Cancer Genetics Unit, C.N.R., TraversaLa Crucca 3, 07040, Sassari, Italy.

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http://dx.doi.org/10.1186/2049-6958-8-45DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3718671PMC
July 2013
33 Reads
9 Citations

Molecular analysis of appendiceal mucinous cystadenoma and rectal adenocarcinoma in a patient with urothelial carcinoma: a case report.

J Med Case Rep 2013 Jun 28;7:170. Epub 2013 Jun 28.

Department of Surgical, Microsurgical and Medical Sciences, University of Sassari, Viale San Pietro 43B, 07100 Sassari, Italy.

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http://dx.doi.org/10.1186/1752-1947-7-170DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3702410PMC
June 2013
11 Reads

Primary dermal melanoma in a patient with a history of multiple malignancies: a case report with molecular characterization.

Case Rep Dermatol 2013 May 18;5(2):192-7. Epub 2013 Jul 18.

Department of Surgical, Microsurgical and Medical Sciences, University of Sassari, Baronissi, Italy.

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http://dx.doi.org/10.1159/000354032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3728608PMC
May 2013
32 Reads
1 Citation

Epidemiology of thyroid cancer in an area of epidemic thyroid goiter.

J Cancer Epidemiol 2013 4;2013:584768. Epub 2013 Mar 4.

Department of Surgical, Microsurgical and Medical Sciences, University of Sassari, Via le San Pietro 43B, 07100 Sassari, Italy.

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http://dx.doi.org/10.1155/2013/584768DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3603222PMC
March 2013
31 Reads
3 Citations

Correction of an end colostomy prolapse with the Delorme technique. A case report.

Ann Ital Chir 2012 Nov-Dec;83(6):567-9

Department of Surgery, Microsurgery and Medical, Surgical Specialties, University of Sassari, Sassari, Italy.

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January 2013
10 Reads
0.683 Impact Factor

Impact of age on the quality of lymphadenectomy for colorectal cancer.

Cancer Invest 2013 Jan 19;31(1):39-42. Epub 2012 Dec 19.

Department of Surgical, Microsurgical and Medical Sciences, Surgical Pathology, University of Sassari, Sassari, Italy.

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http://dx.doi.org/10.3109/07357907.2012.749266DOI Listing
January 2013
25 Reads
1 Citation
2.060 Impact Factor

Warthin-like papillary carcinoma of the thyroid gland: case report and review of the literature.

Case Rep Oncol Med 2012 2;2012:689291. Epub 2012 Dec 2.

Department of Surgical, Microsurgical and Medical Sciences, University of Sassari, 07100 Sassari, Italy.

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http://dx.doi.org/10.1155/2012/689291DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3518096PMC
December 2012
10 Reads
3 Citations

Axillary lymph node dissection in patients with breast cancer and sentinel lymph node micrometastasis or isolated tumor cells: is it necessary?

Tumori 2012 May-Jun;98(3):320-3

Department of Surgical, Microsurgical and Medical Sciences, University of Sassari, Sassari, Italy.

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http://dx.doi.org/10.1700/1125.12399DOI Listing
October 2012
8 Reads
1 Citation
1.090 Impact Factor

Low-grade fibromatosis-like spindle cell metaplastic carcinoma of the breast: a case report and literature review.

Clin Breast Cancer 2012 Apr;12(2):147-50

Institute of Surgical Pathology, University of Sassari, Sassari, Italy.

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http://dx.doi.org/10.1016/j.clbc.2012.01.011DOI Listing
April 2012
10 Reads
5 Citations
2.110 Impact Factor

Conservative management of minor anastomotic leakage after open elective colorectal surgery.

Ann Ital Chir 2012 Jan-Feb;83(1):25-8

Department of Surgery, Microsurgery and Medical, Surgical Specialties, Institute of Surgical Pathology, University of Sassari, Sassari, Italy.

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April 2012
12 Reads
1 Citation
0.683 Impact Factor

[Gastrointestinal stromal tumors].

Ann Ital Chir 2011 Nov-Dec;82(6):515-6

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January 2012
8 Reads
0.683 Impact Factor

Surgical management of the glomus tumors of the fingers: a single center experience.

Ann Ital Chir 2011 Nov-Dec;82(6):465-8

Istituto di Patologia Chirurgica, Università di Sassari, Italy.

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January 2012
9 Reads
0.683 Impact Factor

[Surgical management of a voluminous abdominal paraganglioma and review of the literature].

Ann Ital Chir 2011 May-Jun;82(3):211-5

Istituto di Patologia Chirurgica, Università degli Studi di Sassari.

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August 2011
11 Reads
0.683 Impact Factor

[IPTH dosage as a prognosis predictor of postoperatory hypocalcemia in patients submitted to total thyroidectomy].

Ann Ital Chir 2011 Mar-Apr;82(2):111-5

Istituto di Patologia Chirurgica, Università degli Studi di Sassari Italia.

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July 2011
9 Reads
0.683 Impact Factor

T2-T4 sympathectomy versus T3-T4 sympathicotomy for palmar and axillary hyperhidrosis.

Clin Auton Res 2011 Apr 19;21(2):97-102. Epub 2011 Jan 19.

Department of Surgical Pathology, University of Sassari, Viale San Pietro 43b, 07100, Sassari, Italy.

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http://dx.doi.org/10.1007/s10286-010-0110-6DOI Listing
April 2011
49 Reads
2 Citations
1.864 Impact Factor

Multimodality approach to malignant pleural mesothelioma. A case report.

Ann Ital Chir 2010 Jan-Feb;81(1):37-40

Istituto di Patologia Chirurgica, Università degli Studi di Sassari, Italia.

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September 2010
11 Reads
1 Citation
0.683 Impact Factor

[Functional sequelae after low anterior rectal surgery].

Ann Ital Chir 2009 May-Jun;80(3):193-7

Istituto di Patologia Chirurgica, AOU, Sassari, Italy.

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March 2010
13 Reads
1 Citation
0.683 Impact Factor

Top co-authors

Antonio Cossu
Antonio Cossu

University of Sassari

26
Giuseppe Palmieri
Giuseppe Palmieri

University of Sassari

25
Angelo Zinellu
Angelo Zinellu

University of Sassari

24
Ciriaco Carru
Ciriaco Carru

University of Sassari

23
Mario Trignano
Mario Trignano

University of Sassari

19
Federico Attene
Federico Attene

Università degli Studi di Sassari

18
Maria Colombino
Maria Colombino

University of Sassari

17
Fabrizio Scognamillo
Fabrizio Scognamillo

University of Sassari

15
Arduino A Mangoni
Arduino A Mangoni

School of Medicine

13
Antonella Manca
Antonella Manca

Institute of Biomolecular Chemistry

12