Publications by authors named "Pan-Chyr Yang"

100Publications

Monocarboxylate Transporter 4 Is a Therapeutic Target in Non-small Cell Lung Cancer with Aerobic Glycolysis Preference.

Mol Ther Oncolytics 2020 Sep 24;18:189-201. Epub 2020 Jun 24.

Department of Internal Medicine, College of Medicine, National Taiwan University, Taipei 10051, Taiwan.

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http://dx.doi.org/10.1016/j.omto.2020.06.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7364124PMC
September 2020

Precision radiotherapy for non-small cell lung cancer.

J Biomed Sci 2020 Jul 22;27(1):82. Epub 2020 Jul 22.

Graduate Institute of Oncology, National Taiwan University College of Medicine, Taipei, Taiwan.

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http://dx.doi.org/10.1186/s12929-020-00676-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7374898PMC
July 2020

Nanomodified strategies to overcome EGFR-tyrosine kinase inhibitors resistance in non-small cell lung cancer.

J Control Release 2020 Aug 1;324:482-492. Epub 2020 Jun 1.

Institute of Biomedical Sciences, Academia Sinica, Taipei 11529, Taiwan; The Genomics Research Center, Academia Sinica, Taipei 11529, Taiwan; Department of Internal Medicine, National Taiwan University College of Medicine, Taipei 10051, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.jconrel.2020.05.043DOI Listing
August 2020

Suppression of Drug-Resistant Non-Small-Cell Lung Cancer with Inhibitors Targeting Minichromosomal Maintenance Protein.

J Med Chem 2020 03 17;63(6):3172-3187. Epub 2020 Mar 17.

Genome and Systems Biology Degree Program, National Taiwan University and Academia Sinica, Taipei 100, Taiwan.

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http://dx.doi.org/10.1021/acs.jmedchem.9b01783DOI Listing
March 2020

Precision Management of Advanced Non-Small Cell Lung Cancer.

Annu Rev Med 2020 01;71:117-136

Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan; email:

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http://dx.doi.org/10.1146/annurev-med-051718-013524DOI Listing
January 2020

Use of DosR Dormancy Antigens from for Serodiagnosis of Active and Latent Tuberculosis.

ACS Infect Dis 2020 02 20;6(2):272-280. Epub 2019 Dec 20.

Department of Biomedical Sciences and Institute of Molecular Biology , National Chung Cheng University , No. 168 University Road, Min-Hsiung , Chia-Yi , Taiwan 62102 , ROC.

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http://dx.doi.org/10.1021/acsinfecdis.9b00329DOI Listing
February 2020

Discovery of an Oleanolic Acid/Hederagenin-Nitric Oxide Donor Hybrid as an EGFR Tyrosine Kinase Inhibitor for Non-Small-Cell Lung Cancer.

J Nat Prod 2019 11 13;82(11):3065-3073. Epub 2019 Nov 13.

Natural Products Research Laboratories, UNC Eshelman School of Pharmacy , University of North Carolina , Chapel Hill , North Carolina 27599-7369 , United States.

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http://dx.doi.org/10.1021/acs.jnatprod.9b00659DOI Listing
November 2019

4(1H)-quinolone derivatives overcome acquired resistance to anti-microtubule agents by targeting the colchicine site of β-tubulin.

Eur J Med Chem 2019 Nov 2;181:111584. Epub 2019 Aug 2.

Program in Molecular Medicine, National Yang-Ming University and Academia Sinica, Taipei, Taiwan; Institute of Biomedical Sciences, Academia Sinica, Taipei, 115, Taiwan; Department of Internal Medicine, College of Medicine, National Taiwan University, Taipei, 100, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2019.111584DOI Listing
November 2019

Taiwan's health-care system and administration are independent of China.

Lancet 2019 10 15;394(10208):1516. Epub 2019 Jul 15.

Genomics Research Center, Academia Sinica, Taipei, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/S0140-6736(19)31622-8DOI Listing
October 2019

Tuberculosis infection and lung adenocarcinoma: Mendelian randomization and pathway analysis of genome-wide association study data from never-smoking Asian women.

Authors:
Jason Y Y Wong Han Zhang Chao A Hsiung Kouya Shiraishi Kai Yu Keitaro Matsuo Maria Pik Wong Yun-Chul Hong Jiucun Wang Wei Jie Seow Zhaoming Wang Minsun Song Hee Nam Kim I-Shou Chang Nilanjan Chatterjee Wei Hu Chen Wu Tetsuya Mitsudomi Wei Zheng Jin Hee Kim Adeline Seow Neil E Caporaso Min-Ho Shin Lap Ping Chung She-Juan An Ping Wang Yang Yang Hong Zheng Yasushi Yatabe Xu-Chao Zhang Young Tae Kim Qiuyin Cai Zhihua Yin Young-Chul Kim Bryan A Bassig Jiang Chang James Chung Man Ho Bu-Tian Ji Yataro Daigo Hidemi Ito Yukihide Momozawa Kyota Ashikawa Yoichiro Kamatani Takayuki Honda H Dean Hosgood Hiromi Sakamoto Hideo Kunitoh Koji Tsuta Shun-Ichi Watanabe Michiaki Kubo Yohei Miyagi Haruhiko Nakayama Shingo Matsumoto Masahiro Tsuboi Koichi Goto Jianxin Shi Lei Song Xing Hua Atsushi Takahashi Akiteru Goto Yoshihiro Minamiya Kimihiro Shimizu Kazumi Tanaka Fusheng Wei Fumihiko Matsuda Jian Su Yeul Hong Kim In-Jae Oh Fengju Song Wu-Chou Su Yu-Min Chen Gee-Chen Chang Kuan-Yu Chen Ming-Shyan Huang Li-Hsin Chien Yong-Bing Xiang Jae Yong Park Sun-Seog Kweon Chien-Jen Chen Kyoung-Mu Lee Batel Blechter Haixin Li Yu-Tang Gao Biyun Qian Daru Lu Jianjun Liu Hyo-Sung Jeon Chin-Fu Hsiao Jae Sook Sung Ying-Huang Tsai Yoo Jin Jung Huan Guo Zhibin Hu Wen-Chang Wang Charles C Chung Laurie Burdett Meredith Yeager Amy Hutchinson Sonja I Berndt Wei Wu Herbert Pang Yuqing Li Jin Eun Choi Kyong Hwa Park Sook Whan Sung Li Liu C H Kang Meng Zhu Chung-Hsing Chen Tsung-Ying Yang Jun Xu Peng Guan Wen Tan Chih-Liang Wang Michael Hsin Ko-Yung Sit James Ho Ying Chen Yi Young Choi Jen-Yu Hung Jun Suk Kim Ho Il Yoon Chien-Chung Lin In Kyu Park Ping Xu Yuzhuo Wang Qincheng He Reury-Perng Perng Chih-Yi Chen Roel Vermeulen Junjie Wu Wei-Yen Lim Kun-Chieh Chen Yao-Jen Li Jihua Li Hongyan Chen Chong-Jen Yu Li Jin Tzu-Yu Chen Shih-Sheng Jiang Jie Liu Taiki Yamaji Belynda Hicks Kathleen Wyatt Shengchao A Li Juncheng Dai Hongxia Ma Guangfu Jin Bao Song Zhehai Wang Sensen Cheng Xuelian Li Yangwu Ren Ping Cui Motoki Iwasaki Taichi Shimazu Shoichiro Tsugane Junjie Zhu Ying Chen Kaiyun Yang Gening Jiang Ke Fei Guoping Wu Hsien-Chin Lin Hui-Ling Chen Yao-Huei Fang Fang-Yu Tsai Wan-Shan Hsieh Jinming Yu Victoria L Stevens Ite A Laird-Offringa Crystal N Marconett Linda Rieswijk Ann Chao Pan-Chyr Yang Xiao-Ou Shu Tangchun Wu Y L Wu Dongxin Lin Kexin Chen Baosen Zhou Yun-Chao Huang Takashi Kohno Hongbing Shen Stephen J Chanock Nathaniel Rothman Qing Lan

Genomics 2020 03 12;112(2):1223-1232. Epub 2019 Jul 12.

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.

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http://dx.doi.org/10.1016/j.ygeno.2019.07.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6954985PMC
March 2020

Cancer-Associated Fibroblasts Produce Netrin-1 to Control Cancer Cell Plasticity.

Cancer Res 2019 07 14;79(14):3651-3661. Epub 2019 May 14.

Apoptosis, Cancer and Development Laboratory - Equipe labellisée 'La Ligue', LabEX DEVweCAN, Institut Convergence Plascan, Centre de Cancérologie de Lyon, INSERM U1052-CNRS UMR5286, Université de Lyon, Université Claude Bernard Lyon1, Centre Léon Bérard, Lyon, France.

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http://dx.doi.org/10.1158/0008-5472.CAN-18-2952DOI Listing
July 2019

A Novel TNF-α-Targeting Aptamer for TNF-α-Mediated Acute Lung Injury and Acute Liver Failure.

Theranostics 2019 28;9(6):1741-1751. Epub 2019 Feb 28.

Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.

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http://www.thno.org/v09p1741.htm
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http://dx.doi.org/10.7150/thno.30972DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6485186PMC
March 2020

Population-Based Cohort Study Reveals Distinct Associations Between Female Lung Cancer and Breast Cancer in Taiwan.

JCO Clin Cancer Inform 2018 12;2:1-14

Emily Pei-Ying Lin and Ching-Yao Yang, National Taiwan University Hospital; Chong-Jen Yu, K. Arnold Chan, and Pan-Chyr Yang, National Taiwan University Hospital and College of Medicine; Tzu-Pin Lu, National Taiwan University; Bo-Tsang Huang and Pan-Chyr Yang, Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan; Ching-Heng Lin, Shih-Ni Chang, and Tzu-Hung Hsiao, Taichung Veterans General Hospital; and Shih-Ni Chang, China Medical University Hospital, Taichung, Taiwan.

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http://ascopubs.org/doi/10.1200/CCI.18.00065
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http://dx.doi.org/10.1200/CCI.18.00065DOI Listing
December 2018

Hypoxia-induced Slug SUMOylation enhances lung cancer metastasis.

J Exp Clin Cancer Res 2019 Jan 6;38(1). Epub 2019 Jan 6.

Graduate Institute of Medical Genomics and Proteomics, College of Medicine, National Taiwan University, No. 2, Syu-Jhou Rd, Taipei, 100, Taiwan.

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https://jeccr.biomedcentral.com/articles/10.1186/s13046-018-
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http://dx.doi.org/10.1186/s13046-018-0996-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322271PMC
January 2019

EGFR-Mutant SCLC Exhibits Heterogeneous Phenotypes and Resistance to Common Antineoplastic Drugs.

J Thorac Oncol 2019 03 3;14(3):513-526. Epub 2018 Dec 3.

Department of Internal Medicine, National Taiwan University Hospital, Taiwan. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15560864183349
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http://dx.doi.org/10.1016/j.jtho.2018.11.021DOI Listing
March 2019

Targeting Tumor Microenvironment by Bioreduction-Activated Nanoparticles for Light-Triggered Virotherapy.

ACS Nano 2018 10 5;12(10):9894-9902. Epub 2018 Oct 5.

Institute of Medical Science and Technology , National Sun Yat-sen University , Kaohsiung 80424 , Taiwan.

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http://dx.doi.org/10.1021/acsnano.8b02813DOI Listing
October 2018

Trajectories of caregiver burden and related factors in family caregivers of patients with lung cancer.

Psychooncology 2018 06 30;27(6):1493-1500. Epub 2018 Mar 30.

School of Nursing, College of Medicine, National Taiwan University, Taipei, Taiwan.

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http://dx.doi.org/10.1002/pon.4678DOI Listing
June 2018

FAM198B Is Associated with Prolonged Survival and Inhibits Metastasis in Lung Adenocarcinoma via Blockage of ERK-Mediated MMP-1 Expression.

Clin Cancer Res 2018 02 7;24(4):916-926. Epub 2017 Dec 7.

Department of Clinical and Laboratory Sciences and Medical Biotechnology, National Taiwan University College of Medicine, Taipei, Taiwan.

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http://dx.doi.org/10.1158/1078-0432.CCR-17-1347DOI Listing
February 2018

Astrocyte-elevated gene-1 confers resistance to pemetrexed in non-small cell lung cancer by upregulating thymidylate synthase expression.

Oncotarget 2017 Sep 28;8(37):61901-61916. Epub 2017 Jun 28.

Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan.

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http://dx.doi.org/10.18632/oncotarget.18717DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5617473PMC
September 2017

A CTLA-4 Antagonizing DNA Aptamer with Antitumor Effect.

Mol Ther Nucleic Acids 2017 Sep 15;8:520-528. Epub 2017 Aug 15.

Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan; Department of Internal Medicine, National Taiwan University Hospital and College of Medicine, National Taiwan University, Taipei, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.omtn.2017.08.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5573796PMC
September 2017

Lung adenocarcinoma patients of young age have lower mutation rate and poorer efficacy of EGFR tyrosine kinase inhibitors.

ERJ Open Res 2017 Jul 12;3(3). Epub 2017 Jul 12.

Dept of Internal Medicine, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taiwan.

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http://dx.doi.org/10.1183/23120541.00092-2016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5507146PMC
July 2017

Upregulation of microRNA-137 expression by Slug promotes tumor invasion and metastasis of non-small cell lung cancer cells through suppression of TFAP2C.

Cancer Lett 2017 08 10;402:190-202. Epub 2017 Jun 10.

Department of Internal Medicine, National Taiwan University Hospital, National Taiwan University, Taipei 10002, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2017.06.002DOI Listing
August 2017

Phosphoproteomics Reveals HMGA1, a CK2 Substrate, as a Drug-Resistant Target in Non-Small Cell Lung Cancer.

Sci Rep 2017 03 14;7:44021. Epub 2017 Mar 14.

Chemical Biology and Molecular Biophysics Program, Taiwan International Graduate Program, Institute of Chemistry, Academia Sinica, Taipei, 11529, Taiwan.

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http://dx.doi.org/10.1038/srep44021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5349541PMC
March 2017

High PD-L1 expression is associated with stage IV disease and poorer overall survival in 186 cases of small cell lung cancers.

Oncotarget 2017 Mar;8(11):18021-18030

Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei 10002, Taiwan.

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http://dx.doi.org/10.18632/oncotarget.14935DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5392304PMC
March 2017

Turning Diversity Toward Precision.

J Natl Cancer Inst 2017 Jan;109(1):1-2

Department of Internal Medicine, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan.

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http://dx.doi.org/10.1093/jnci/djw238DOI Listing
January 2017

Association between GWAS-identified lung adenocarcinoma susceptibility loci and EGFR mutations in never-smoking Asian women, and comparison with findings from Western populations.

Authors:
Wei Jie Seow Keitaro Matsuo Chao Agnes Hsiung Kouya Shiraishi Minsun Song Hee Nam Kim Maria Pik Wong Yun-Chul Hong H Dean Hosgood Zhaoming Wang I-Shou Chang Jiu-Cun Wang Nilanjan Chatterjee Margaret Tucker Hu Wei Tetsuya Mitsudomi Wei Zheng Jin Hee Kim Baosen Zhou Neil E Caporaso Demetrius Albanes Min-Ho Shin Lap Ping Chung She-Juan An Ping Wang Hong Zheng Yasushi Yatabe Xu-Chao Zhang Young Tae Kim Xiao-Ou Shu Young-Chul Kim Bryan A Bassig Jiang Chang James Chung Man Ho Bu-Tian Ji Michiaki Kubo Yataro Daigo Hidemi Ito Yukihide Momozawa Kyota Ashikawa Yoichiro Kamatani Takayuki Honda Hiromi Sakamoto Hideo Kunitoh Koji Tsuta Shun-Ichi Watanabe Hiroshi Nokihara Yohei Miyagi Haruhiko Nakayama Shingo Matsumoto Masahiro Tsuboi Koichi Goto Zhihua Yin Jianxin Shi Atsushi Takahashi Akiteru Goto Yoshihiro Minamiya Kimihiro Shimizu Kazumi Tanaka Tangchun Wu Fusheng Wei Jason Y Y Wong Fumihiko Matsuda Jian Su Yeul Hong Kim In-Jae Oh Fengju Song Victor Ho Fun Lee Wu-Chou Su Yuh-Min Chen Gee-Chen Chang Kuan-Yu Chen Ming-Shyan Huang Pan-Chyr Yang Hsien-Chih Lin Yong-Bing Xiang Adeline Seow Jae Yong Park Sun-Seog Kweon Chien-Jen Chen Haixin Li Yu-Tang Gao Chen Wu Biyun Qian Daru Lu Jianjun Liu Hyo-Sung Jeon Chin-Fu Hsiao Jae Sook Sung Ying-Huang Tsai Yoo Jin Jung Huan Guo Zhibin Hu Wen-Chang Wang Charles C Chung Charles Lawrence Laurie Burdett Meredith Yeager Kevin B Jacobs Amy Hutchinson Sonja I Berndt Xingzhou He Wei Wu Junwen Wang Yuqing Li Jin Eun Choi Kyong Hwa Park Sook Whan Sung Li Liu Chang Hyun Kang Lingmin Hu Chung-Hsing Chen Tsung-Ying Yang Jun Xu Peng Guan Wen Tan Chih-Liang Wang Alan Dart Loon Sihoe Ying Chen Yi Young Choi Jen-Yu Hung Jun Suk Kim Ho-Il Yoon Qiuyin Cai Chien-Chung Lin In Kyu Park Ping Xu Jing Dong Christopher Kim Qincheng He Reury-Perng Perng Chih-Yi Chen Roel Vermeulen Junjie Wu Wei-Yen Lim Kun-Chieh Chen John K C Chan Minjie Chu Yao-Jen Li Jihua Li Hongyan Chen Chong-Jen Yu Li Jin Yen-Li Lo Ying-Hsiang Chen Joseph F Fraumeni Jie Liu Taiki Yamaji Yang Yang Belynda Hicks Kathleen Wyatt Shengchao A Li Juncheng Dai Hongxia Ma Guangfu Jin Bao Song Zhehai Wang Sensen Cheng Xuelian Li Yangwu Ren Ping Cui Motoki Iwasaki Taichi Shimazu Shoichiro Tsugane Junjie Zhu Gening Jiang Ke Fei Guoping Wu Li-Hsin Chien Hui-Ling Chen Yu-Chun Su Fang-Yu Tsai Yi-Song Chen Jinming Yu Victoria L Stevens Ite A Laird-Offringa Crystal N Marconett Dongxin Lin Kexin Chen Yi-Long Wu Maria Teresa Landi Hongbing Shen Nathaniel Rothman Takashi Kohno Stephen J Chanock Qing Lan

Hum Mol Genet 2017 01;26(2):454-465

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.

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http://dx.doi.org/10.1093/hmg/ddw414DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5856088PMC
January 2017

A Novel PD-L1-targeting Antagonistic DNA Aptamer With Antitumor Effects.

Mol Ther Nucleic Acids 2016 Dec 13;5(12):e397. Epub 2016 Dec 13.

Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.

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http://dx.doi.org/10.1038/mtna.2016.102DOI Listing
December 2016

Remote Control of Light-Triggered Virotherapy.

ACS Nano 2016 11 7;10(11):10339-10346. Epub 2016 Nov 7.

Institute of Biomedical Sciences, Academia Sinica , Taipei 11529, Taiwan.

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http://dx.doi.org/10.1021/acsnano.6b06051DOI Listing
November 2016

Kinesin-5 Contributes to Spindle-length Scaling in the Evolution of Cancer toward Metastasis.

Sci Rep 2016 10 21;6:35767. Epub 2016 Oct 21.

Institute of Molecular and Cellular Biology, National Taiwan University, Taipei 10617, Taiwan.

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http://dx.doi.org/10.1038/srep35767DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5073351PMC
October 2016

The Role of PIK3CA Mutations among Lung Adenocarcinoma Patients with Primary and Acquired Resistance to EGFR Tyrosine Kinase Inhibition.

Sci Rep 2016 10 13;6:35249. Epub 2016 Oct 13.

Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan.

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http://dx.doi.org/10.1038/srep35249DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5062358PMC
October 2016

Mesenchymal Transitions in Development and Disease.

Stem Cells Int 2016 2;2016:5107517. Epub 2016 Aug 2.

School of Medicine and Surgery, University of Milano-Bicocca, 20900 Monza, Italy.

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http://dx.doi.org/10.1155/2016/5107517DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4985584PMC
August 2016

Randomized Phase II Trial of Gefitinib With and Without Pemetrexed as First-Line Therapy in Patients With Advanced Nonsquamous Non-Small-Cell Lung Cancer With Activating Epidermal Growth Factor Receptor Mutations.

J Clin Oncol 2016 09 9;34(27):3258-66. Epub 2016 Aug 9.

Ying Cheng, Jilin Provincial Cancer Hospital, Changchun; Jianxing He, The First Affiliated Hospital of Guangzhou Medical University, Guangdong; Xin Wang, Eli Lilly, Shanghai, China; Haruyasu Murakami, Shizuoka Cancer Center, Shizuoka; Kazuhiko Nakagawa, Kinki University School of Medicine, Osaka; Sotaro Enatsu, Eli Lilly Japan, Kobe, Japan; Pan-Chyr Yang and James Chih-Hsin Yang, National Taiwan University Hospital; James Chih-Hsin Yang, National Taiwan University Cancer Center, Taipei, Taiwan; Jin Hyoung Kang, The Catholic University of Korea, Seoul; Joo-Hang Kim, CHA Bundang Medical Center, CHA University, Gyeonggi-do, Korea; Tarun Puri, Eli Lilly, Gurgaon, Haryana, India; and Mauro Orlando, Eli Lilly Interamérica, Buenos Aires, Argentina.

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http://dx.doi.org/10.1200/JCO.2016.66.9218DOI Listing
September 2016

Female chromosome X mosaicism is age-related and preferentially affects the inactivated X chromosome.

Authors:
Mitchell J Machiela Weiyin Zhou Eric Karlins Joshua N Sampson Neal D Freedman Qi Yang Belynda Hicks Casey Dagnall Christopher Hautman Kevin B Jacobs Christian C Abnet Melinda C Aldrich Christopher Amos Laufey T Amundadottir Alan A Arslan Laura E Beane-Freeman Sonja I Berndt Amanda Black William J Blot Cathryn H Bock Paige M Bracci Louise A Brinton H Bas Bueno-de-Mesquita Laurie Burdett Julie E Buring Mary A Butler Federico Canzian Tania Carreón Kari G Chaffee I-Shou Chang Nilanjan Chatterjee Chu Chen Constance Chen Kexin Chen Charles C Chung Linda S Cook Marta Crous Bou Michael Cullen Faith G Davis Immaculata De Vivo Ti Ding Jennifer Doherty Eric J Duell Caroline G Epstein Jin-Hu Fan Jonine D Figueroa Joseph F Fraumeni Christine M Friedenreich Charles S Fuchs Steven Gallinger Yu-Tang Gao Susan M Gapstur Montserrat Garcia-Closas Mia M Gaudet J Michael Gaziano Graham G Giles Elizabeth M Gillanders Edward L Giovannucci Lynn Goldin Alisa M Goldstein Christopher A Haiman Goran Hallmans Susan E Hankinson Curtis C Harris Roger Henriksson Elizabeth A Holly Yun-Chul Hong Robert N Hoover Chao A Hsiung Nan Hu Wei Hu David J Hunter Amy Hutchinson Mazda Jenab Christoffer Johansen Kay-Tee Khaw Hee Nam Kim Yeul Hong Kim Young Tae Kim Alison P Klein Robert Klein Woon-Puay Koh Laurence N Kolonel Charles Kooperberg Peter Kraft Vittorio Krogh Robert C Kurtz Andrea LaCroix Qing Lan Maria Teresa Landi Loic Le Marchand Donghui Li Xiaolin Liang Linda M Liao Dongxin Lin Jianjun Liu Jolanta Lissowska Lingeng Lu Anthony M Magliocco Nuria Malats Keitaro Matsuo Lorna H McNeill Robert R McWilliams Beatrice S Melin Lisa Mirabello Lee Moore Sara H Olson Irene Orlow Jae Yong Park Ana Patiño-Garcia Beata Peplonska Ulrike Peters Gloria M Petersen Loreall Pooler Jennifer Prescott Ludmila Prokunina-Olsson Mark P Purdue You-Lin Qiao Preetha Rajaraman Francisco X Real Elio Riboli Harvey A Risch Benjamin Rodriguez-Santiago Avima M Ruder Sharon A Savage Fredrick Schumacher Ann G Schwartz Kendra L Schwartz Adeline Seow Veronica Wendy Setiawan Gianluca Severi Hongbing Shen Xin Sheng Min-Ho Shin Xiao-Ou Shu Debra T Silverman Margaret R Spitz Victoria L Stevens Rachael Stolzenberg-Solomon Daniel Stram Ze-Zhong Tang Philip R Taylor Lauren R Teras Geoffrey S Tobias David Van Den Berg Kala Visvanathan Sholom Wacholder Jiu-Cun Wang Zhaoming Wang Nicolas Wentzensen William Wheeler Emily White John K Wiencke Brian M Wolpin Maria Pik Wong Chen Wu Tangchun Wu Xifeng Wu Yi-Long Wu Jay S Wunder Lucy Xia Hannah P Yang Pan-Chyr Yang Kai Yu Krista A Zanetti Anne Zeleniuch-Jacquotte Wei Zheng Baosen Zhou Regina G Ziegler Luis A Perez-Jurado Neil E Caporaso Nathaniel Rothman Margaret Tucker Michael C Dean Meredith Yeager Stephen J Chanock

Nat Commun 2016 06 13;7:11843. Epub 2016 Jun 13.

Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1038/ncomms11843DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4909985PMC
June 2016

The Prognostic Significance of pSTAT1 and CD163 Expressions in Surgically Resected Stage 1 Pulmonary Squamous Cell Carcinomas.

Ann Surg Oncol 2016 09 5;23(9):3071-81. Epub 2016 May 5.

Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.

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http://dx.doi.org/10.1245/s10434-016-5244-xDOI Listing
September 2016

High co-expression of PD-L1 and HIF-1α correlates with tumour necrosis in pulmonary pleomorphic carcinoma.

Eur J Cancer 2016 06 22;60:125-35. Epub 2016 Apr 22.

Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, No. 7, Chung-Shan S. Rd., Taipei 10002, Taiwan; Graduate Institute of Pathology, National Taiwan University College of Medicine, No. 7, Chung-Shan S. Rd., Taipei 10002, Taiwan; National Taiwan University, No. 1, Sec. 4, Roosevelt Rd., Taipei 10617, Taiwan.

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http://dx.doi.org/10.1016/j.ejca.2016.03.012DOI Listing
June 2016

Efficacy of Pemetrexed-Based Chemotherapy in Patients with ROS1 Fusion-Positive Lung Adenocarcinoma Compared with in Patients Harboring Other Driver Mutations in East Asian Populations.

J Thorac Oncol 2016 07 16;11(7):1140-52. Epub 2016 Apr 16.

Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei 10002, Republic of China; Department of Internal Medicine, National Taiwan University Hospital, Taipei, Republic of China. Electronic address:

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http://dx.doi.org/10.1016/j.jtho.2016.03.022DOI Listing
July 2016

Association of BIM Deletion Polymorphism With Intrinsic Resistance to EGFR Tyrosine Kinase Inhibitors in Patients With Lung Adenocarcinoma.

JAMA Oncol 2016 Jun;2(6):826-8

Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei City, Taiwan3Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.

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http://dx.doi.org/10.1001/jamaoncol.2016.0016DOI Listing
June 2016

Noncoding RNAs in Tumor Epithelial-to-Mesenchymal Transition.

Stem Cells Int 2016 16;2016:2732705. Epub 2016 Feb 16.

Institute of Biomedical Sciences, Academia Sinica, Taipei 11529, Taiwan; Department of Internal Medicine, National Taiwan University Hospital and College of Medicine, National Taiwan University, Taipei 70101, Taiwan.

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http://dx.doi.org/10.1155/2016/2732705DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4773551PMC
March 2016

Heterogeneous nuclear ribonucleoproteins A1 and A2 modulate expression of Tid1 isoforms and EGFR signaling in non-small cell lung cancer.

Oncotarget 2016 Mar;7(13):16760-72

Department of Molecular and Cellular Biology, College of Medicine, Chang Gung University, Kwei-San, Tao-Yuan 333, Taiwan.

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March 2016

Programmed cell death-ligand 1 expression is associated with a favourable immune microenvironment and better overall survival in stage I pulmonary squamous cell carcinoma.

Eur J Cancer 2016 Apr 21;57:91-103. Epub 2016 Feb 21.

Department of Internal Medicine, Taiwan, ROC; Graduate Institute of Pathology, National Taiwan University College of Medicine, Taipei 10002, Taiwan, ROC.

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April 2016

Factors in Association Between Parkinson Disease and Risk of Cancer in Taiwan--Reply.

JAMA Oncol 2016 Jan;2(1):145-6

Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan4Department of Internal Medicine, National Taiwan University Hospital and College of Medicine, National Taiwan University, Taipei, Taiwan.

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January 2016

MicroRNA and Pathogenesis of Enterovirus Infection.

Viruses 2016 Jan 6;8(1). Epub 2016 Jan 6.

Department of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, No. 1 Chang-Te Street, Taipei 10048, Taiwan.

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January 2016

Meta-analysis of genome-wide association studies identifies multiple lung cancer susceptibility loci in never-smoking Asian women.

Authors:
Zhaoming Wang Wei Jie Seow Kouya Shiraishi Chao A Hsiung Keitaro Matsuo Jie Liu Kexin Chen Taiki Yamji Yang Yang I-Shou Chang Chen Wu Yun-Chul Hong Laurie Burdett Kathleen Wyatt Charles C Chung Shengchao A Li Meredith Yeager Amy Hutchinson Wei Hu Neil Caporaso Maria T Landi Nilanjan Chatterjee Minsun Song Joseph F Fraumeni Takashi Kohno Jun Yokota Hideo Kunitoh Kyota Ashikawa Yukihide Momozawa Yataro Daigo Tetsuya Mitsudomi Yasushi Yatabe Toyoaki Hida Zhibin Hu Juncheng Dai Hongxia Ma Guangfu Jin Bao Song Zhehai Wang Sensen Cheng Zhihua Yin Xuelian Li Yangwu Ren Peng Guan Jiang Chang Wen Tan Chien-Jen Chen Gee-Chen Chang Ying-Huang Tsai Wu-Chou Su Kuan-Yu Chen Ming-Shyan Huang Yuh-Min Chen Hong Zheng Haixin Li Ping Cui Huan Guo Ping Xu Li Liu Motoki Iwasaki Taichi Shimazu Shoichiro Tsugane Junjie Zhu Gening Jiang Ke Fei Jae Yong Park Yeul Hong Kim Jae Sook Sung Kyong Hwa Park Young Tae Kim Yoo Jin Jung Chang Hyun Kang In Kyu Park Hee Nam Kim Hyo-Sung Jeon Jin Eun Choi Yi Young Choi Jin Hee Kim In-Jae Oh Young-Chul Kim Sook Whan Sung Jun Suk Kim Ho-Il Yoon Sun-Seog Kweon Min-Ho Shin Adeline Seow Ying Chen Wei-Yen Lim Jianjun Liu Maria Pik Wong Victor Ho Fun Lee Bryan A Bassig Margaret Tucker Sonja I Berndt Wong-Ho Chow Bu-Tian Ji Junwen Wang Jun Xu Alan Dart Loon Sihoe James C M Ho John K C Chan Jiu-Cun Wang Daru Lu Xueying Zhao Zhenhong Zhao Junjie Wu Hongyan Chen Li Jin Fusheng Wei Guoping Wu She-Juan An Xu-Chao Zhang Jian Su Yi-Long Wu Yu-Tang Gao Yong-Bing Xiang Xingzhou He Jihua Li Wei Zheng Xiao-Ou Shu Qiuyin Cai Robert Klein William Pao Charles Lawrence H Dean Hosgood Chin-Fu Hsiao Li-Hsin Chien Ying-Hsiang Chen Chung-Hsing Chen Wen-Chang Wang Chih-Yi Chen Chih-Liang Wang Chong-Jen Yu Hui-Ling Chen Yu-Chun Su Fang-Yu Tsai Yi-Song Chen Yao-Jen Li Tsung-Ying Yang Chien-Chung Lin Pan-Chyr Yang Tangchun Wu Dongxin Lin Baosen Zhou Jinming Yu Hongbing Shen Michiaki Kubo Stephen J Chanock Nathaniel Rothman Qing Lan

Hum Mol Genet 2016 Feb 4;25(3):620-9. Epub 2016 Jan 4.

Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD, USA.

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February 2016

Novel Noxipoint Therapy versus Conventional Physical Therapy for Chronic Neck and Shoulder Pain: Multicentre Randomised Controlled Trials.

Sci Rep 2015 Nov 10;5:16342. Epub 2015 Nov 10.

Diagnostic Radiology, Department of Radiology, Stanford University Medical Centre, Stanford, CA 94305, U.S.A.

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November 2015

Analysis of Heritability and Shared Heritability Based on Genome-Wide Association Studies for Thirteen Cancer Types.

Authors:
Joshua N Sampson William A Wheeler Meredith Yeager Orestis Panagiotou Zhaoming Wang Sonja I Berndt Qing Lan Christian C Abnet Laufey T Amundadottir Jonine D Figueroa Maria Teresa Landi Lisa Mirabello Sharon A Savage Philip R Taylor Immaculata De Vivo Katherine A McGlynn Mark P Purdue Preetha Rajaraman Hans-Olov Adami Anders Ahlbom Demetrius Albanes Maria Fernanda Amary She-Juan An Ulrika Andersson Gerald Andriole Irene L Andrulis Emanuele Angelucci Stephen M Ansell Cecilia Arici Bruce K Armstrong Alan A Arslan Melissa A Austin Dalsu Baris Donald A Barkauskas Bryan A Bassig Nikolaus Becker Yolanda Benavente Simone Benhamou Christine Berg David Van Den Berg Leslie Bernstein Kimberly A Bertrand Brenda M Birmann Amanda Black Heiner Boeing Paolo Boffetta Marie-Christine Boutron-Ruault Paige M Bracci Louise Brinton Angela R Brooks-Wilson H Bas Bueno-de-Mesquita Laurie Burdett Julie Buring Mary Ann Butler Qiuyin Cai Geraldine Cancel-Tassin Federico Canzian Alfredo Carrato Tania Carreon Angela Carta John K C Chan Ellen T Chang Gee-Chen Chang I-Shou Chang Jiang Chang Jenny Chang-Claude Chien-Jen Chen Chih-Yi Chen Chu Chen Chung-Hsing Chen Constance Chen Hongyan Chen Kexin Chen Kuan-Yu Chen Kun-Chieh Chen Ying Chen Ying-Hsiang Chen Yi-Song Chen Yuh-Min Chen Li-Hsin Chien María-Dolores Chirlaque Jin Eun Choi Yi Young Choi Wong-Ho Chow Charles C Chung Jacqueline Clavel Françoise Clavel-Chapelon Pierluigi Cocco Joanne S Colt Eva Comperat Lucia Conde Joseph M Connors David Conti Victoria K Cortessis Michelle Cotterchio Wendy Cozen Simon Crouch Marta Crous-Bou Olivier Cussenot Faith G Davis Ti Ding W Ryan Diver Miren Dorronsoro Laure Dossus Eric J Duell Maria Grazia Ennas Ralph L Erickson Maria Feychting Adrienne M Flanagan Lenka Foretova Joseph F Fraumeni Neal D Freedman Laura E Beane Freeman Charles Fuchs Manuela Gago-Dominguez Steven Gallinger Yu-Tang Gao Susan M Gapstur Montserrat Garcia-Closas Reina García-Closas Randy D Gascoyne Julie Gastier-Foster Mia M Gaudet J Michael Gaziano Carol Giffen Graham G Giles Edward Giovannucci Bengt Glimelius Michael Goggins Nalan Gokgoz Alisa M Goldstein Richard Gorlick Myron Gross Robert Grubb Jian Gu Peng Guan Marc Gunter Huan Guo Thomas M Habermann Christopher A Haiman Dina Halai Goran Hallmans Manal Hassan Claudia Hattinger Qincheng He Xingzhou He Kathy Helzlsouer Brian Henderson Roger Henriksson Henrik Hjalgrim Judith Hoffman-Bolton Chancellor Hohensee Theodore R Holford Elizabeth A Holly Yun-Chul Hong Robert N Hoover Pamela L Horn-Ross G M Monawar Hosain H Dean Hosgood Chin-Fu Hsiao Nan Hu Wei Hu Zhibin Hu Ming-Shyan Huang Jose-Maria Huerta Jen-Yu Hung Amy Hutchinson Peter D Inskip Rebecca D Jackson Eric J Jacobs Mazda Jenab Hyo-Sung Jeon Bu-Tian Ji Guangfu Jin Li Jin Christoffer Johansen Alison Johnson Yoo Jin Jung Rudolph Kaaks Aruna Kamineni Eleanor Kane Chang Hyun Kang Margaret R Karagas Rachel S Kelly Kay-Tee Khaw Christopher Kim Hee Nam Kim Jin Hee Kim Jun Suk Kim Yeul Hong Kim Young Tae Kim Young-Chul Kim Cari M Kitahara Alison P Klein Robert J Klein Manolis Kogevinas Takashi Kohno Laurence N Kolonel Charles Kooperberg Anne Kricker Vittorio Krogh Hideo Kunitoh Robert C Kurtz Sun-Seog Kweon Andrea LaCroix Charles Lawrence Fernando Lecanda Victor Ho Fun Lee Donghui Li Haixin Li Jihua Li Yao-Jen Li Yuqing Li Linda M Liao Mark Liebow Tracy Lightfoot Wei-Yen Lim Chien-Chung Lin Dongxin Lin Sara Lindstrom Martha S Linet Brian K Link Chenwei Liu Jianjun Liu Li Liu Börje Ljungberg Josep Lloreta Simonetta Di Lollo Daru Lu Eiluv Lund Nuria Malats Satu Mannisto Loic Le Marchand Neyssa Marina Giovanna Masala Giuseppe Mastrangelo Keitaro Matsuo Marc Maynadie James McKay Roberta McKean-Cowdin Mads Melbye Beatrice S Melin Dominique S Michaud Tetsuya Mitsudomi Alain Monnereau Rebecca Montalvan Lee E Moore Lotte Maxild Mortensen Alexandra Nieters Kari E North Anne J Novak Ann L Oberg Kenneth Offit In-Jae Oh Sara H Olson Domenico Palli William Pao In Kyu Park Jae Yong Park Kyong Hwa Park Ana Patiño-Garcia Sofia Pavanello Petra H M Peeters Reury-Perng Perng Ulrike Peters Gloria M Petersen Piero Picci Malcolm C Pike Stefano Porru Jennifer Prescott Ludmila Prokunina-Olsson Biyun Qian You-Lin Qiao Marco Rais Elio Riboli Jacques Riby Harvey A Risch Cosmeri Rizzato Rebecca Rodabough Eve Roman Morgan Roupret Avima M Ruder Silvia de Sanjose Ghislaine Scelo Alan Schned Fredrick Schumacher Kendra Schwartz Molly Schwenn Katia Scotlandi Adeline Seow Consol Serra Massimo Serra Howard D Sesso Veronica Wendy Setiawan Gianluca Severi Richard K Severson Tait D Shanafelt Hongbing Shen Wei Shen Min-Ho Shin Kouya Shiraishi Xiao-Ou Shu Afshan Siddiq Luis Sierrasesúmaga Alan Dart Loon Sihoe Christine F Skibola Alex Smith Martyn T Smith Melissa C Southey John J Spinelli Anthony Staines Meir Stampfer Marianna C Stern Victoria L Stevens Rachael S Stolzenberg-Solomon Jian Su Wu-Chou Su Malin Sund Jae Sook Sung Sook Whan Sung Wen Tan Wei Tang Adonina Tardón David Thomas Carrie A Thompson Lesley F Tinker Roberto Tirabosco Anne Tjønneland Ruth C Travis Dimitrios Trichopoulos Fang-Yu Tsai Ying-Huang Tsai Margaret Tucker Jenny Turner Claire M Vajdic Roel C H Vermeulen Danylo J Villano Paolo Vineis Jarmo Virtamo Kala Visvanathan Jean Wactawski-Wende Chaoyu Wang Chih-Liang Wang Jiu-Cun Wang Junwen Wang Fusheng Wei Elisabete Weiderpass George J Weiner Stephanie Weinstein Nicolas Wentzensen Emily White Thomas E Witzig Brian M Wolpin Maria Pik Wong Chen Wu Guoping Wu Junjie Wu Tangchun Wu Wei Wu Xifeng Wu Yi-Long Wu Jay S Wunder Yong-Bing Xiang Jun Xu Ping Xu Pan-Chyr Yang Tsung-Ying Yang Yuanqing Ye Zhihua Yin Jun Yokota Ho-Il Yoon Chong-Jen Yu Herbert Yu Kai Yu Jian-Min Yuan Andrew Zelenetz Anne Zeleniuch-Jacquotte Xu-Chao Zhang Yawei Zhang Xueying Zhao Zhenhong Zhao Hong Zheng Tongzhang Zheng Wei Zheng Baosen Zhou Meng Zhu Mariagrazia Zucca Simina M Boca James R Cerhan Giovanni M Ferri Patricia Hartge Chao Agnes Hsiung Corrado Magnani Lucia Miligi Lindsay M Morton Karin E Smedby Lauren R Teras Joseph Vijai Sophia S Wang Paul Brennan Neil E Caporaso David J Hunter Peter Kraft Nathaniel Rothman Debra T Silverman Susan L Slager Stephen J Chanock Nilanjan Chatterjee

J Natl Cancer Inst 2015 Dec 12;107(12):djv279. Epub 2015 Oct 12.

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD (JNS, OP, SIB, QL, CCA, LTA, JDF, MTL, LM, SAS, PRT, KAM, PR, DA, DB, BAB, AB, LBr, WHC, CCC, JSC, JFFJr, NDF, LEBF, MGC, AMG, RNH, NH, WH, PDI, BTJ, CK, CMK, LML, MSL, LEM, LPO, RSSS, WeiT, MT, CWa, SW, NW, KY, PH, LMM, NEC, NR, DTS, SJC, NC); Information Management Services, Silver Spring, MD (WAW, CG); Cancer Genomics Research Laboratory, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Gaithersburg, MD (MY, ZW, LBu, AH, CLi); Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA (IDV, KAB, BMB, CoC, MCB, CF, EG, SL, JP, MSt, DJH); Department of Epidemiology, Harvard School of Public Health, Boston, MA (IDV, OA, KAB, CoC, MCB, EG, RSK, SL, JP, HDS, MSt, DTr, DJH, PK); Ontario Health Study, Toronto, Ontario, Canada (MPP); Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden (HOA, EWe); Unit of Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden (AA, MF); UCL Cancer Institute, London, UK (MFA, AMF, DH); Royal National Orthopaedic Hospital NHS Trust, Stanmore, Middlesex, UK (MFA, AMF, DH, RT); Guangdong Lung Cancer Institute, Guangdong Provincial Key Laboratory of Translational Medicine in Lung Cancer, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China (SJA, JS, YLW, XCZ); Department of Radiation Sciences, Oncology, Umea University, Umea, Sweden (UA, RH, BSM); Division of Urologic Surgery, Washington University School of Medicine, Saint Louis, MO (GAJr, RGIII); Litwin Centre for Cancer Genetics, University of Toronto, Ontario, Canada (ILA, NG, JSW); Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada (ILA, SG, NG, JSW); Hematology Unit, Ospedale Oncologico di Riferimento Regionale A. Businco, Cagliari, Italy (EA); Department of Medicin

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December 2015

Opposite Effects of M1 and M2 Macrophage Subtypes on Lung Cancer Progression.

Sci Rep 2015 Sep 24;5:14273. Epub 2015 Sep 24.

Department of Internal Medicine, National Taiwan University College of Medicine, Taipei, Taiwan.

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September 2015

EGFR-L858R mutant enhances lung adenocarcinoma cell invasive ability and promotes malignant pleural effusion formation through activation of the CXCL12-CXCR4 pathway.

Sci Rep 2015 Sep 4;5:13574. Epub 2015 Sep 4.

Department of Internal Medicine, National Taiwan University Hospital, and College of Medicine, National Taiwan University, Taipei 10002, Taiwan.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4559673PMC
September 2015

Estrogen Receptor Gene Polymorphisms and Lung Adenocarcinoma Risk in Never-Smoking Women.

J Thorac Oncol 2015 Oct;10(10):1413-20

*Division of Pulmonary Medicine, Department of Internal Medicine, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan; †Division of Biostatistics and Bioinformatics, Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan; ‡Division of Chest Medicine, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan; §Department of Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan; ‖Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Chang Gung Memorial Hospital, Chiayi, Taiwan; ¶Division of Hematology/Oncology, Department of Internal Medicine, National Cheng Kung University, Tainan, Taiwan; #Department of Chest Medicine, Taipei Veterans General Hospital, School of Medicine, National Yang-Ming University, and Taipei Cancer Center, Taipei Medical University, Taipei, Taiwan; **Department of Internal Medicine, Kaohsiung Medical University Hospital, School of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; ††National Institute of Cancer Research, National Health Research Institutes, Zhunan, Taiwan; ‡‡Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan; §§Institute of Medicine, Chung-Shan Medical University, Taichung, Taiwan; ‖‖Department of Thoracic Surgery, Chung Shan Medical University Hospital, Taichung, Taiwan; ¶¶Genomics Research Center, Academia Sinica, Taipei, Taiwan; and ##Graduate Institute of Epidemiology, College of Public Health, National Taiwan University, Taipei, Taiwan.

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October 2015

Association Between Parkinson Disease and Risk of Cancer in Taiwan.

JAMA Oncol 2015 Aug;1(5):633-40

Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan4Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University Medical College, Taipei, Taiwan.

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August 2015

Gender-Dimorphic Impact of PXR Genotype and Haplotype on Hepatotoxicity During Antituberculosis Treatment.

Medicine (Baltimore) 2015 Jun;94(24):e982

From the Department of Internal Medicine, National Taiwan University Hospital (JYW, CLH, CJY, PCY); Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University (CHT, YLL); and Department of Laboratory Medicine, National Taiwan University Hospital, Zhongzheng District, Taipei, Taiwan (LNL, HCC, JMC, CAH).

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June 2015

R331W Missense Mutation of Oncogene YAP1 Is a Germline Risk Allele for Lung Adenocarcinoma With Medical Actionability.

J Clin Oncol 2015 Jul 8;33(20):2303-10. Epub 2015 Jun 8.

Hsuan-Yu Chen, Yi-Chiung Hsu, Chi-Sheng Chang, Yu-Cheng Li, Hao Ho, Ya-Hsuan Chang, Shinsheng Yuan, Chia-Hsin Liu, Guan-I Wu, and Ker-Chau Li, Institute of Statistical Science, and Shi-Yi Yang, Hwai-I Yang, and Chien-Jen Chen, Genomics Research Center, Academia Sinica; Hsuan-Yu Chen, Sung-Liang Yu, Bing-Ching Ho, Kang-Yi Su, and Pin-Yen Hsu, College of Medicine; Hsuan-Yu Chen, College of Life Science; Sung-Liang Yu, Kang-Yi Su, and Pan-Chyr Yang, Center of Genomic Medicine; Huei-Wen Chen, Graduate Institute of Toxicology, National Taiwan University; Sung-Liang Yu, Chong-Jen Yu, Kuan-Yu Chen, and Pan-Chyr Yang, National Taiwan University Hospital; Yuh-Min Chen, Taipei Veterans General Hospital; Chung-Ping Hsu, Tsung-Ying Yang, and Gee-Chen Chang, School of Medicine, National Yang-Ming University; Mei-Hsuan Lee, Institute of Clinical Medicine, National Yang-Ming University, Taipei; Chih-Yi Chen, Chung Shan Medical University; Chung-Ping Hsu, Tsung-Ying Yang, Kun-Chieh Chen, Kuo-Hsuan Hsu, Jeng-Sen Tseng, Jiun-Yi Hsia, Cheng-Yen Chuang, and Gee-Chen Chang, Taichung Veterans General Hospital; Kun-Chieh Chen, Kuo-Hsuan Hsu, Jeng-Sen Tseng, and Jeremy J.W. Chen, Institute of Biomedical Sciences, National Chung-Hsing University; Gee-Chen Chang, Comprehensive Cancer Center, Taichung Veterans General Hospital, Taichung; Chao A. Hsiung, Institute of Population Health Sciences, National Health Research Institutes, Zhunan; Chih-Liang Wang, Chang Gung Memorial Hospital, Tao-Yuan; Ying-Huang Tsai, Chang-Gung Memorial Hospital, Chia-Yi; Ming-Shyan Huang, Kaohsiung Medical University Hospital, College of Medicine, Kaohsiung Medical University, Kaohsiung; Wu-Chou Su, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan; and Ker-Chau Li, University of California Los Angeles, Los Angeles, CA.

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July 2015

Pathway-based gene signatures predicting clinical outcome of lung adenocarcinoma.

Sci Rep 2015 Jun 4;5:10979. Epub 2015 Jun 4.

Department of Internal Medicine, National Taiwan University College of Medicine, No.1, Section 1, Jen-Ai Road, Taipei, Taiwan.

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June 2015

Effect of sialylation on EGFR phosphorylation and resistance to tyrosine kinase inhibition.

Proc Natl Acad Sci U S A 2015 Jun 13;112(22):6955-60. Epub 2015 May 13.

Institute of Biochemical Sciences and Genomics Research Center,

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June 2015

PD-L1 is highly expressed in lung lymphoepithelioma-like carcinoma: A potential rationale for immunotherapy.

Lung Cancer 2015 Jun 21;88(3):254-9. Epub 2015 Mar 21.

Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan; Graduate Institute of Pathology, National Taiwan University College of Medicine, Taipei, Taiwan; National Taiwan University, Taipei, Taiwan.

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http://dx.doi.org/10.1016/j.lungcan.2015.03.017DOI Listing
June 2015

Identification of five driver gene mutations in patients with treatment-naïve lung adenocarcinoma in Taiwan.

PLoS One 2015 19;10(3):e0120852. Epub 2015 Mar 19.

Institute of Biomedical Sciences, National Chung Hsing University, Taichung, Taiwan; Division of Chest Medicine, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan; Faculty of Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4366385PMC
December 2015

Novel curcumin analogs to overcome EGFR-TKI lung adenocarcinoma drug resistance and reduce EGFR-TKI-induced GI adverse effects.

Bioorg Med Chem 2015 Apr 13;23(7):1507-1514. Epub 2015 Feb 13.

Natural Products Research Laboratories, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599-7568, USA.

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April 2015

Characterization of large structural genetic mosaicism in human autosomes.

Authors:
Mitchell J Machiela Weiyin Zhou Joshua N Sampson Michael C Dean Kevin B Jacobs Amanda Black Louise A Brinton I-Shou Chang Chu Chen Constance Chen Kexin Chen Linda S Cook Marta Crous Bou Immaculata De Vivo Jennifer Doherty Christine M Friedenreich Mia M Gaudet Christopher A Haiman Susan E Hankinson Patricia Hartge Brian E Henderson Yun-Chul Hong H Dean Hosgood Chao A Hsiung Wei Hu David J Hunter Lea Jessop Hee Nam Kim Yeul Hong Kim Young Tae Kim Robert Klein Peter Kraft Qing Lan Dongxin Lin Jianjun Liu Loic Le Marchand Xiaolin Liang Jolanta Lissowska Lingeng Lu Anthony M Magliocco Keitaro Matsuo Sara H Olson Irene Orlow Jae Yong Park Loreall Pooler Jennifer Prescott Radhai Rastogi Harvey A Risch Fredrick Schumacher Adeline Seow Veronica Wendy Setiawan Hongbing Shen Xin Sheng Min-Ho Shin Xiao-Ou Shu David VanDen Berg Jiu-Cun Wang Nicolas Wentzensen Maria Pik Wong Chen Wu Tangchun Wu Yi-Long Wu Lucy Xia Hannah P Yang Pan-Chyr Yang Wei Zheng Baosen Zhou Christian C Abnet Demetrius Albanes Melinda C Aldrich Christopher Amos Laufey T Amundadottir Sonja I Berndt William J Blot Cathryn H Bock Paige M Bracci Laurie Burdett Julie E Buring Mary A Butler Tania Carreón Nilanjan Chatterjee Charles C Chung Michael B Cook Michael Cullen Faith G Davis Ti Ding Eric J Duell Caroline G Epstein Jin-Hu Fan Jonine D Figueroa Joseph F Fraumeni Neal D Freedman Charles S Fuchs Yu-Tang Gao Susan M Gapstur Ana Patiño-Garcia Montserrat Garcia-Closas J Michael Gaziano Graham G Giles Elizabeth M Gillanders Edward L Giovannucci Lynn Goldin Alisa M Goldstein Mark H Greene Goran Hallmans Curtis C Harris Roger Henriksson Elizabeth A Holly Robert N Hoover Nan Hu Amy Hutchinson Mazda Jenab Christoffer Johansen Kay-Tee Khaw Woon-Puay Koh Laurence N Kolonel Charles Kooperberg Vittorio Krogh Robert C Kurtz Andrea LaCroix Annelie Landgren Maria Teresa Landi Donghui Li Linda M Liao Nuria Malats Katherine A McGlynn Lorna H McNeill Robert R McWilliams Beatrice S Melin Lisa Mirabello Beata Peplonska Ulrike Peters Gloria M Petersen Ludmila Prokunina-Olsson Mark Purdue You-Lin Qiao Kari G Rabe Preetha Rajaraman Francisco X Real Elio Riboli Benjamín Rodríguez-Santiago Nathaniel Rothman Avima M Ruder Sharon A Savage Ann G Schwartz Kendra L Schwartz Howard D Sesso Gianluca Severi Debra T Silverman Margaret R Spitz Victoria L Stevens Rachael Stolzenberg-Solomon Daniel Stram Ze-Zhong Tang Philip R Taylor Lauren R Teras Geoffrey S Tobias Kala Viswanathan Sholom Wacholder Zhaoming Wang Stephanie J Weinstein William Wheeler Emily White John K Wiencke Brian M Wolpin Xifeng Wu Jay S Wunder Kai Yu Krista A Zanetti Anne Zeleniuch-Jacquotte Regina G Ziegler Mariza de Andrade Kathleen C Barnes Terri H Beaty Laura J Bierut Karl C Desch Kimberly F Doheny Bjarke Feenstra David Ginsburg John A Heit Jae H Kang Cecilia A Laurie Jun Z Li William L Lowe Mary L Marazita Mads Melbye Daniel B Mirel Jeffrey C Murray Sarah C Nelson Louis R Pasquale Kenneth Rice Janey L Wiggs Anastasia Wise Margaret Tucker Luis A Pérez-Jurado Cathy C Laurie Neil E Caporaso Meredith Yeager Stephen J Chanock

Am J Hum Genet 2015 Mar;96(3):487-97

Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA. Electronic address:

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March 2015

Severe lymphopenia is associated with elevated plasma interleukin-15 levels and increased mortality during severe sepsis.

Shock 2015 Jun;43(6):569-75

*Department of Internal Medicine, National Taiwan University Hospital Hsin-Chu Branch, National Taiwan University College of Medicine, Hsin-Chu, Taiwan; †Department of Laboratory Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan; ‡Department of Internal Medicine and Department of Critical Care Medicine, Far Eastern Memorial Hospital, New Taipei, Taiwan; §Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan; ∥Department of Epidemiology, Warren Alpert Medical School of Brown University, Rhode Island, USA; and ¶Department of Medical Research, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.

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June 2015

Estimated Creatinine Clearance Rate Is Associated With the Treatment Effectiveness and Toxicity of Pemetrexed As Continuation Maintenance Therapy for Advanced Nonsquamous Non-Small-Cell Lung Cancer.

Clin Lung Cancer 2015 Nov 10;16(6):e131-40. Epub 2015 Jan 10.

Division of Pulmonary Medicine, Department of Internal Medicine, National Taiwan University Hospital and College of Medicine, National Taiwan University, Taipei, Taiwan.

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November 2015

Genetic variants associated with longer telomere length are associated with increased lung cancer risk among never-smoking women in Asia: a report from the female lung cancer consortium in Asia.

Authors:
Mitchell J Machiela Chao Agnes Hsiung Xiao-Ou Shu Wei Jie Seow Zhaoming Wang Keitaro Matsuo Yun-Chul Hong Adeline Seow Chen Wu H Dean Hosgood Kexin Chen Jiu-Cun Wang Wanqing Wen Richard Cawthon Nilanjan Chatterjee Wei Hu Neil E Caporaso Jae Yong Park Chien-Jen Chen Yeul Hong Kim Young Tae Kim Maria Teresa Landi Hongbing Shen Charles Lawrence Laurie Burdett Meredith Yeager I-Shou Chang Tetsuya Mitsudomi Hee Nam Kim Gee-Chen Chang Bryan A Bassig Margaret Tucker Fusheng Wei Zhihua Yin She-Juan An Biyun Qian Victor Ho Fun Lee Daru Lu Jianjun Liu Hyo-Sung Jeon Chin-Fu Hsiao Jae Sook Sung Jin Hee Kim Yu-Tang Gao Ying-Huang Tsai Yoo Jin Jung Huan Guo Zhibin Hu Amy Hutchinson Wen-Chang Wang Robert J Klein Charles C Chung In-Jae Oh Kuan-Yu Chen Sonja I Berndt Wei Wu Jiang Chang Xu-Chao Zhang Ming-Shyan Huang Hong Zheng Junwen Wang Xueying Zhao Yuqing Li Jin Eun Choi Wu-Chou Su Kyong Hwa Park Sook Whan Sung Yuh-Min Chen Li Liu Chang Hyun Kang Lingmin Hu Chung-Hsing Chen William Pao Young-Chul Kim Tsung-Ying Yang Jun Xu Peng Guan Wen Tan Jian Su Chih-Liang Wang Haixin Li Alan Dart Loon Sihoe Zhenhong Zhao Ying Chen Yi Young Choi Jen-Yu Hung Jun Suk Kim Ho-Il Yoon Qiuyin Cai Chien-Chung Lin In Kyu Park Ping Xu Jing Dong Christopher Kim Qincheng He Reury-Perng Perng Takashi Kohno Sun-Seog Kweon Chih-Yi Chen Roel C H Vermeulen Junjie Wu Wei-Yen Lim Kun-Chieh Chen Wong-Ho Chow Bu-Tian Ji John K C Chan Minjie Chu Yao-Jen Li Jun Yokota Jihua Li Hongyan Chen Yong-Bing Xiang Chong-Jen Yu Hideo Kunitoh Guoping Wu Li Jin Yen-Li Lo Kouya Shiraishi Ying-Hsiang Chen Hsien-Chih Lin Tangchun Wu Maria Pik Wong Yi-Long Wu Pan-Chyr Yang Baosen Zhou Min-Ho Shin Joseph F Fraumeni Wei Zheng Dongxin Lin Stephen J Chanock Nathaniel Rothman Qing Lan

Int J Cancer 2015 Jul 29;137(2):311-9. Epub 2014 Dec 29.

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD.

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http://dx.doi.org/10.1002/ijc.29393DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4733320PMC
July 2015

miR-146a and miR-370 coordinate enterovirus 71-induced cell apoptosis through targeting SOS1 and GADD45β.

Cell Microbiol 2015 Jun 24;17(6):802-18. Epub 2015 Jan 24.

Institute of Molecular Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan.

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http://doi.wiley.com/10.1111/cmi.12401
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http://dx.doi.org/10.1111/cmi.12401DOI Listing
June 2015