Pamela Shaw

Pamela Shaw

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Pamela Shaw

Publications by authors named "Pamela Shaw"

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Critical design considerations for time-to-event endpoints in amyotrophic lateral sclerosis clinical trials.

J Neurol Neurosurg Psychiatry 2019 Dec 10;90(12):1331-1337. Epub 2019 Jul 10.

Department of Neurology, Brain Center Rudolf Magnus, University Medical Centre Utrecht, Utrecht, The Netherlands.

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http://dx.doi.org/10.1136/jnnp-2019-320998DOI Listing
December 2019

Effect of Escalating Financial Incentive Rewards on Maintenance of Weight Loss: A Randomized Clinical Trial.

JAMA Netw Open 2019 Nov 1;2(11):e1914393. Epub 2019 Nov 1.

Leonard Davis Institute Center for Health Incentives and Behavioral Economics, Perelman School of Medicine, University of Pennsylvania, Philadelphia.

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http://dx.doi.org/10.1001/jamanetworkopen.2019.14393DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826643PMC
November 2019

Disrupted glycosylation of lipids and proteins is a cause of neurodegeneration.

Brain 2019 Nov 14. Epub 2019 Nov 14.

Sheffield Institute for Translational Neuroscience (SITraN), Sheffield, UK.

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http://dx.doi.org/10.1093/brain/awz358DOI Listing
November 2019

Longitudinal multi-modal muscle-based biomarker assessment in motor neuron disease.

J Neurol 2019 Oct 17. Epub 2019 Oct 17.

Sheffield Institute for Translational Neuroscience, University of Sheffield, 385a Glossop Road, Sheffield, S10 2HQ, UK.

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http://dx.doi.org/10.1007/s00415-019-09580-xDOI Listing
October 2019

Using telehealth in motor neuron disease to increase access to specialist multidisciplinary care: a UK-based pilot and feasibility study.

BMJ Open 2019 Oct 22;9(10):e028525. Epub 2019 Oct 22.

Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield, UK.

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http://dx.doi.org/10.1136/bmjopen-2018-028525DOI Listing
October 2019

Process evaluation and exploration of telehealth in motor neuron disease in a UK specialist centre.

BMJ Open 2019 Oct 22;9(10):e028526. Epub 2019 Oct 22.

Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield, UK.

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http://dx.doi.org/10.1136/bmjopen-2018-028526DOI Listing
October 2019

Analyses of Physical Activity and Health-Are Our Methods Too Sedentary?

Authors:
Pamela A Shaw

JAMA Netw Open 2019 Oct 2;2(10):e1914085. Epub 2019 Oct 2.

Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia.

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http://dx.doi.org/10.1001/jamanetworkopen.2019.14085DOI Listing
October 2019

The role of mitochondria in amyotrophic lateral sclerosis.

Neurosci Lett 2019 Sep 30;710:132933. Epub 2017 Jun 30.

Sheffield Institute for Translational Neuroscience (SITraN), Department of Neuroscience, University of Sheffield, Sheffield, S10 2HQ, UK. Electronic address:

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http://dx.doi.org/10.1016/j.neulet.2017.06.052DOI Listing
September 2019

The effect of transfer to adult transplant care on kidney function and immunosuppressant drug level variability in pediatric kidney transplant recipients.

Pediatr Transplant 2019 Sep 17;23(6):e13527. Epub 2019 Jun 17.

Division of Nephrology, Department of Pediatrics, Children's Hospital of Philadelphia, and University of Pennsylvania, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1111/petr.13527DOI Listing
September 2019

Associations of plasma, RBCs, and hair carbon and nitrogen isotope ratios with fish, meat, and sugar-sweetened beverage intake in a 12-wk inpatient feeding study.

Am J Clin Nutr 2019 Sep 12. Epub 2019 Sep 12.

Center for Alaska Native Health Research, Institute of Arctic Biology, Department of Biology and Wildlife, University of Alaska Fairbanks, Fairbanks, AK, USA.

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http://dx.doi.org/10.1093/ajcn/nqz208DOI Listing
September 2019

Multiwalled Carbon Nanotubes of Varying Size Lead to DNA Methylation Changes That Correspond to Lung Inflammation and Injury in a Mouse Model.

Chem Res Toxicol 2019 Aug 16;32(8):1545-1553. Epub 2019 Jul 16.

Center for Environmental Health Sciences, Department of Biomedical and Pharmaceutical Sciences , University of Montana , Missoula , Montana 59812 , United States.

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http://dx.doi.org/10.1021/acs.chemrestox.9b00075DOI Listing
August 2019

C9orf72 intermediate expansions of 24-30 repeats are associated with ALS.

Acta Neuropathol Commun 2019 Jul 17;7(1):115. Epub 2019 Jul 17.

Department of Basic and Clinical Neuroscience, King's College London, Maurice Wohl Clinical Neuroscience Institute, London, UK.

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http://dx.doi.org/10.1186/s40478-019-0724-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6637621PMC
July 2019

Hazard ratio inference in stratified clinical trials with time-to-event endpoints and limited sample size.

Pharm Stat 2019 05 31;18(3):366-376. Epub 2019 Jan 31.

Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1002/pst.1928DOI Listing
May 2019

Telomere length is greater in ALS than in controls: a whole genome sequencing study.

Amyotroph Lateral Scler Frontotemporal Degener 2019 05 1;20(3-4):229-234. Epub 2019 Apr 1.

a Department of Basic and Clinical Neuroscience , King's College London, Maurice Wohl Clinical Neuroscience Institute , London , UK.

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http://dx.doi.org/10.1080/21678421.2019.1586951DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6567548PMC
May 2019

Biomarkers in Motor Neuron Disease: A State of the Art Review.

Front Neurol 2019 3;10:291. Epub 2019 Apr 3.

Department of Neuroscience, Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, Sheffield, United Kingdom.

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https://www.frontiersin.org/article/10.3389/fneur.2019.00291
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http://dx.doi.org/10.3389/fneur.2019.00291DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456669PMC
April 2019

Striking phenotypic variation in a family with the P506S UBQLN2 mutation including amyotrophic lateral sclerosis, spastic paraplegia, and frontotemporal dementia.

Neurobiol Aging 2019 01 24;73:229.e5-229.e9. Epub 2018 Aug 24.

United Kingdom Dementia Research Institute Centre, Maurice Wohl Clinical Neuroscience Institute, Institute of Psychiatry, Psychology and Neuroscience, King's College London, Camberwell, London, UK. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01974580183030
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http://dx.doi.org/10.1016/j.neurobiolaging.2018.08.015DOI Listing
January 2019

The Healthy Weigh study of lottery-based incentives and environmental strategies for weight loss: Design and baseline characteristics.

Contemp Clin Trials 2019 01 26;76:24-30. Epub 2018 Oct 26.

University of Pennsylvania Center for Health Incentives and Behavioral Economics, 423 Guardian Drive, 11th Floor Blockley Hall, Philadelphia, PA 19104, United States. Electronic address:

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http://dx.doi.org/10.1016/j.cct.2018.10.013DOI Listing
January 2019

Organophosphate Pesticide Metabolite Concentrations in Urine during Pregnancy and Offspring Nonverbal IQ at Age 6 Years.

Environ Health Perspect 2019 01;127(1):17007

Epidemiology Branch, National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH), Department of Health and Human Services, Durham, North Carolina, USA.

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https://ehp.niehs.nih.gov/doi/10.1289/EHP3024
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http://dx.doi.org/10.1289/EHP3024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381821PMC
January 2019

Novel genotype-phenotype and MRI correlations in a large cohort of patients with mutations.

Neurol Genet 2018 Dec 24;4(6):e279. Epub 2018 Oct 24.

Academic Directorate of Neurosciences (C.A.A.H., R.O'.M., M.K.R., S.P., Z.P., S.B., C.J.M., P.J.S., M.H.), Sheffield Teaching Hospitals NHS Foundation Trust, Royal Hallamshire Hospital; Sheffield Institute for Translational Neuroscience (SITraN) (C.A.A.H., R.S., T.R., C.J.M., P.J.S., M.H.), University of Sheffield; Sheffield Diagnostic Genetics Service (N.J.B., J.M.), Sheffield Children's NHS Foundation Trust; Department of Clinical Neurophysiology (G.R., P.S.), Sheffield Teaching Hospitals NHS Foundation Trust, Royal Hallamshire Hospital; Academic Unit of Radiology (N.H.), University of Sheffield, Royal Hallamshire Hospital; and Sheffield NIHR Biomedical Research Centre for Translational Neuroscience (C.A.A.H., N.H., R.S., P.S., S.B., C.J.M., P.J.S., M.H.), United Kingdom.

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http://dx.doi.org/10.1212/NXG.0000000000000279DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6244025PMC
December 2018

Thyroid Dysfunction in Heart Failure and Cardiovascular Outcomes.

Circ Heart Fail 2018 12;11(12):e005266

Division of Endocrinology, Diabetes, and Metabolism (L.K., A.R.C.) at the Perelman School of Medicine at the University of Pennsylvania, Philadelphia.

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http://dx.doi.org/10.1161/CIRCHEARTFAILURE.118.005266DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352308PMC
December 2018

Epidemiologic analyses with error-prone exposures: review of current practice and recommendations.

Ann Epidemiol 2018 11 18;28(11):821-828. Epub 2018 Sep 18.

Information Management Services, Inc, Rockville, MD; Biostatistics Unit, Gertner Institute for Epidemiology and Health Policy Research, Sheba Medical Center, Tel Hashomer, Israel.

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https://linkinghub.elsevier.com/retrieve/pii/S10472797183015
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http://dx.doi.org/10.1016/j.annepidem.2018.09.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6734186PMC
November 2018

Stable transgenic C9orf72 zebrafish model key aspects of the ALS/FTD phenotype and reveal novel pathological features.

Acta Neuropathol Commun 2018 11 19;6(1):125. Epub 2018 Nov 19.

Sheffield Institute for Translational Neuroscience, University of Sheffield, 385a Glossop Road, Sheffield, S10 2HQ, UK.

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http://dx.doi.org/10.1186/s40478-018-0629-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6240957PMC
November 2018

Incorporating baseline measurements into the analysis of crossover trials with time-to-event endpoints.

Stat Med 2018 10 11;37(23):3280-3292. Epub 2018 Jun 11.

Department of Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, USA.

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http://doi.wiley.com/10.1002/sim.7834
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http://dx.doi.org/10.1002/sim.7834DOI Listing
October 2018

Ursodeoxycholic Acid Improves Mitochondrial Function and Redistributes Drp1 in Fibroblasts from Patients with Either Sporadic or Familial Alzheimer's Disease.

J Mol Biol 2018 10 29;430(21):3942-3953. Epub 2018 Aug 29.

Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, 385a Glossop Road, Sheffield, S10 2HQ, UK. Electronic address:

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http://dx.doi.org/10.1016/j.jmb.2018.08.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6193139PMC
October 2018

Lost in translation: microRNAs mediate pathological cross-talk between motor neurons and astrocytes.

Brain 2018 09;141(9):2534-2536

Sheffield Institute for Translational Neuroscience, Department of Neuroscience, University of Sheffield, 385 Glossop Road, Sheffield, UK.

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http://dx.doi.org/10.1093/brain/awy213DOI Listing
September 2018

The TiM system: developing a novel telehealth service to improve access to specialist care in motor neurone disease using user-centered design.

Amyotroph Lateral Scler Frontotemporal Degener 2018 08 16;19(5-6):351-361. Epub 2018 Feb 16.

a Sheffield Institute for Translational Neuroscience , University of Sheffield (SITraN) , Sheffield , UK.

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http://dx.doi.org/10.1080/21678421.2018.1440408DOI Listing
August 2018

Efficacy of the Head Up collar in facilitating functional head movements in patients with Amyotrophic Lateral Sclerosis.

Clin Biomech (Bristol, Avon) 2018 08 25;57:114-120. Epub 2018 Jun 25.

NIHR Devices for Dignity MedTech Healthcare Technology Co-operative, Sheffield Teaching Hospitals NHS Foundation Trust, Royal Hallamshire Hospital, Sheffield, UK; Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield, UK.

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http://dx.doi.org/10.1016/j.clinbiomech.2018.06.016DOI Listing
August 2018

Use of composite outcomes to assess risk-benefit in clinical trials.

Authors:
Pamela A Shaw

Clin Trials 2018 08;15(4):352-358

Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.1177/1740774518784010DOI Listing
August 2018

Considerations for analysis of time-to-event outcomes subject to competing risks in veterinary clinical studies.

J Vet Cardiol 2018 Jun 18;20(3):143-153. Epub 2018 Apr 18.

Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, 8th Floor Blockley Hall, 423 Guardian Drive, Philadelphia PA 19104, USA; Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, 8th Floor Blockley Hall, 423 Guardian Drive, Philadelphia PA 19104, USA.

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http://dx.doi.org/10.1016/j.jvc.2018.03.001DOI Listing
June 2018

Financial incentive strategies for maintenance of weight loss: results from an internet-based randomized controlled trial.

Nutr Diabetes 2018 05 25;8(1):33. Epub 2018 May 25.

Leonard Davis Institute Center for Health Incentives and Behavioral Economics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.1038/s41387-018-0036-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5968035PMC
May 2018

Can Astrocytes Be a Target for Precision Medicine?

Adv Exp Med Biol 2017 ;1007:111-128

Department of Neuroscience, Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield, S10 2HQ, UK.

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http://link.springer.com/10.1007/978-3-319-60733-7_7
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http://dx.doi.org/10.1007/978-3-319-60733-7_7DOI Listing
April 2018

Gene Therapy in the Nervous System: Failures and Successes.

Adv Exp Med Biol 2017 ;1007:241-257

Sheffield Institute for Translational Neuroscience, University of Sheffield, 385a Glossop Road, Sheffield, S10 2HQ, UK.

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http://dx.doi.org/10.1007/978-3-319-60733-7_13DOI Listing
April 2018

Considerations for analysis of time-to-event outcomes measured with error: Bias and correction with SIMEX.

Stat Med 2018 04 29;37(8):1276-1289. Epub 2017 Nov 29.

Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, U.S.A.

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http://dx.doi.org/10.1002/sim.7554DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5810403PMC
April 2018

Genome-wide Analyses Identify KIF5A as a Novel ALS Gene.

Authors:
Aude Nicolas Kevin P Kenna Alan E Renton Nicola Ticozzi Faraz Faghri Ruth Chia Janice A Dominov Brendan J Kenna Mike A Nalls Pamela Keagle Alberto M Rivera Wouter van Rheenen Natalie A Murphy Joke J F A van Vugt Joshua T Geiger Rick A Van der Spek Hannah A Pliner Shankaracharya Bradley N Smith Giuseppe Marangi Simon D Topp Yevgeniya Abramzon Athina Soragia Gkazi John D Eicher Aoife Kenna Gabriele Mora Andrea Calvo Letizia Mazzini Nilo Riva Jessica Mandrioli Claudia Caponnetto Stefania Battistini Paolo Volanti Vincenzo La Bella Francesca L Conforti Giuseppe Borghero Sonia Messina Isabella L Simone Francesca Trojsi Fabrizio Salvi Francesco O Logullo Sandra D'Alfonso Lucia Corrado Margherita Capasso Luigi Ferrucci Cristiane de Araujo Martins Moreno Sitharthan Kamalakaran David B Goldstein Aaron D Gitler Tim Harris Richard M Myers Hemali Phatnani Rajeeva Lochan Musunuri Uday Shankar Evani Avinash Abhyankar Michael C Zody Julia Kaye Steven Finkbeiner Stacia K Wyman Alex LeNail Leandro Lima Ernest Fraenkel Clive N Svendsen Leslie M Thompson Jennifer E Van Eyk James D Berry Timothy M Miller Stephen J Kolb Merit Cudkowicz Emily Baxi Michael Benatar J Paul Taylor Evadnie Rampersaud Gang Wu Joanne Wuu Giuseppe Lauria Federico Verde Isabella Fogh Cinzia Tiloca Giacomo P Comi Gianni Sorarù Cristina Cereda Philippe Corcia Hannu Laaksovirta Liisa Myllykangas Lilja Jansson Miko Valori John Ealing Hisham Hamdalla Sara Rollinson Stuart Pickering-Brown Richard W Orrell Katie C Sidle Andrea Malaspina John Hardy Andrew B Singleton Janel O Johnson Sampath Arepalli Peter C Sapp Diane McKenna-Yasek Meraida Polak Seneshaw Asress Safa Al-Sarraj Andrew King Claire Troakes Caroline Vance Jacqueline de Belleroche Frank Baas Anneloor L M A Ten Asbroek José Luis Muñoz-Blanco Dena G Hernandez Jinhui Ding J Raphael Gibbs Sonja W Scholz Mary Kay Floeter Roy H Campbell Francesco Landi Robert Bowser Stefan M Pulst John M Ravits Daniel J L MacGowan Janine Kirby Erik P Pioro Roger Pamphlett James Broach Glenn Gerhard Travis L Dunckley Christopher B Brady Neil W Kowall Juan C Troncoso Isabelle Le Ber Kevin Mouzat Serge Lumbroso Terry D Heiman-Patterson Freya Kamel Ludo Van Den Bosch Robert H Baloh Tim M Strom Thomas Meitinger Aleksey Shatunov Kristel R Van Eijk Mamede de Carvalho Maarten Kooyman Bas Middelkoop Matthieu Moisse Russell L McLaughlin Michael A Van Es Markus Weber Kevin B Boylan Marka Van Blitterswijk Rosa Rademakers Karen E Morrison A Nazli Basak Jesús S Mora Vivian E Drory Pamela J Shaw Martin R Turner Kevin Talbot Orla Hardiman Kelly L Williams Jennifer A Fifita Garth A Nicholson Ian P Blair Guy A Rouleau Jesús Esteban-Pérez Alberto García-Redondo Ammar Al-Chalabi Ekaterina Rogaeva Lorne Zinman Lyle W Ostrow Nicholas J Maragakis Jeffrey D Rothstein Zachary Simmons Johnathan Cooper-Knock Alexis Brice Stephen A Goutman Eva L Feldman Summer B Gibson Franco Taroni Antonia Ratti Cinzia Gellera Philip Van Damme Wim Robberecht Pietro Fratta Mario Sabatelli Christian Lunetta Albert C Ludolph Peter M Andersen Jochen H Weishaupt William Camu John Q Trojanowski Vivianna M Van Deerlin Robert H Brown Leonard H van den Berg Jan H Veldink Matthew B Harms Jonathan D Glass David J Stone Pentti Tienari Vincenzo Silani Adriano Chiò Christopher E Shaw Bryan J Traynor John E Landers

Neuron 2018 03;97(6):1268-1283.e6

Department of Neurology, University of Massachusetts Medical School, Worcester, MA 01605, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2018.02.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5867896PMC
March 2018

Small RNA Sequencing of Sporadic Amyotrophic Lateral Sclerosis Cerebrospinal Fluid Reveals Differentially Expressed miRNAs Related to Neural and Glial Activity.

Front Neurosci 2017 9;11:731. Epub 2018 Jan 9.

Department of Neuroscience, Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield, United Kingdom.

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http://dx.doi.org/10.3389/fnins.2017.00731DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5767269PMC
January 2018

Advances, challenges and future directions for stem cell therapy in amyotrophic lateral sclerosis.

Mol Neurodegener 2017 Nov 13;12(1):85. Epub 2017 Nov 13.

Sheffield Institute for Translational Neuroscience (SITraN), Department of Neuroscience, Faculty of Medicine, Dentistry and Health, University of Sheffield, 385a Glossop Rd S10 2HQ, Sheffield, UK.

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http://dx.doi.org/10.1186/s13024-017-0227-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5683324PMC
November 2017

Targeted Genetic Screen in Amyotrophic Lateral Sclerosis Reveals Novel Genetic Variants with Synergistic Effect on Clinical Phenotype.

Front Mol Neurosci 2017 9;10:370. Epub 2017 Nov 9.

Maurice Wohl Clinical Neuroscience Institute, King's College London, Department of Basic and Clinical Neuroscience, London, United Kingdom; Maurice Wohl Clinical Neuroscience Institute, King's College London, Department of Basic and Clinical Neuroscience, London, United Kingdom; Suna and Inan Kirac Foundation, Neurodegeneration Research Laboratory, Bogazici University, Istanbul, Turkey; Faculty of Medicine and Health Sciences, Macquarie University, Sydney, NSW, Australia; Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, Netherlands; Academic Unit of Neurology, Trinity College Dublin, Trinity Biomedical Sciences Institute, Dublin, Republic of Ireland; Department of Neurology, Beaumont Hospital, Dublin, Republic of Ireland; Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, Sheffield, United Kingdom; Biostatistics Department, Harvard School of Public Health, Boston, MA, United States; Department of Biostatistics, IoPPN, King's College London, London, United Kingdom; Department of Neurology, University of Massachusetts Medical School, Worcester, MA, United States; Department of Neurology, University of Massachusetts Medical School, Worcester, MA, United States; Population Genetics Laboratory, Smurfit Institute of Genetics, Trinity College Dublin, Dublin, Republic of Ireland; Maurice Wohl Clinical Neuroscience Institute, King's College London, Department of Basic and Clinical Neuroscience, London, United Kingdom; University of Exeter Medical School, Exeter University, St. Luke's Campus, Magdalen Street, Exeter EX1 2LU, United Kingdom; Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, Netherlands; KU Leuven - University of Leuven, Department of Neurosciences, Experimental Neurology and Leuven Research Institute for Neuroscience and Disease (LIND), B-3000 Leuven, Belgium; VIB, Vesalius Research Center, Laboratory of Neurobiology, Leuven, Belgium; University Hospitals Leuven, Department of Neurology, Leuven, Belgium; Hospital San Rafael, Madrid, Spain; Faculty of Medicine, University of Southampton, Southampton, United Kingdom; Department of Biostatistics, IoPPN, King's College London, London, United Kingdom; Biomedical Research Centre for Mental Health, IoPPN, King's College London, London, United Kingdom; Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, Netherlands; Maurice Wohl Clinical Neuroscience Institute, King's College London, Department of Basic and Clinical Neuroscience, London, United Kingdom; Maurice Wohl Clinical Neuroscience Institute, King's College London, Department of Basic and Clinical Neuroscience, London, United Kingdom; Maurice Wohl Clinical Neuroscience Institute, King's College London, Department of Basic and Clinical Neuroscience, London, United Kingdom; Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, Netherlands; KU Leuven - University of Leuven, Department of Neurosciences, Experimental Neurology and Leuven Research Institute for Neuroscience and Disease (LIND), B-3000 Leuven, Belgium, VIB, Vesalius Research Center, Laboratory of Neurobiology, Leuven, Belgium; University Hospitals Leuven, Department of Neurology, Leuven, Belgium; Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, Netherlands; Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, Netherlands; Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, Netherlands; Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, Netherlands; Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, Netherlands; Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, Netherlands; Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, Netherlands; SURFsara, Amsterdam, Netherlands; Emory University, Atlanta, United States; KU Leuven - University of Leuven, Department of Neurosciences, Experimental Neurology and Leuven Research Institute for Neuroscience and Disease (LIND), B-3000 Leuven, Belgium; VIB, Vesalius Research Center, Laboratory of Neurobiology, Leuven, Belgium; University Hospitals Leuven, Department of Neurology, Leuven, Belgium; Hadassah University Hospital, Jerusalem, Israel; Tel-Aviv Medical Center, Tel-Aviv, Israel; Faculty of Medicine and Health Sciences, Macquarie University, Sydney, NSW, Australia; Universidade de São Paulo, Brazil; Universidade de São Paulo, Brazil; Université de Limoges, France; Université François-Rabelais, Tours, France; IRCCS Instituto Auxologico Italiano, Milan, Italy; Universita degli Studi dei Torino, Turin, Italy; Instituto de Medicina Molecular, University of Lisbon, Lisbon, Portugal; Instituto de Medicina Molecular, University of Lisbon, Lisbon, Portugal; Hospital Carlos III, Madrid, Spain; Umeå University, Umeå, Sweden; Kantonspittal St. Gallen, St. Gallen, Switzerland; IRCCS Instituto Auxologico Italiano, Milan, Italy.

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http://dx.doi.org/10.3389/fnmol.2017.00370DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5684183PMC
November 2017

Rare genetic variation in UNC13A may modify survival in amyotrophic lateral sclerosis.

Amyotroph Lateral Scler Frontotemporal Degener 2016 Oct - Nov;17(7-8):593-599. Epub 2016 Sep 1.

a Maurice Wohl Clinical Neuroscience Institute, King's College London, Institute of Psychiatry, Psychology and Neuroscience , London , UK.

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http://dx.doi.org/10.1080/21678421.2016.1213852DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5125285PMC
October 2017

Meta-analysis of pharmacogenetic interactions in amyotrophic lateral sclerosis clinical trials.

Neurology 2017 Oct 4;89(18):1915-1922. Epub 2017 Oct 4.

From the Department of Neurology, Brain Centre Rudolf Magnus (R.P.A.v.E., F.P.D., W.v.R., J.H.V., L.H.v.d.B., M.A.v.E.), and Department of Biostatistics and Research Support (M.J.C.E.), University Medical Centre Utrecht, the Netherlands; Maurice Wohl Clinical Neuroscience Institute and United Kingdom Dementia Research Institute Centre (A.R.J., W.S., A.S., C.E.S., A.A.-C.), Department of Basic and Clinical Neuroscience, King's College London; Sheffield Institute for Translational Neuroscience (SITraN) (P.J.S.), University of Sheffield, South Yorkshire; Department of Clinical Neuroscience (P.N.L.), Trafford Centre for Biomedical Research, Brighton and Sussex Medical School, Falmer, Brighton; The Walton Centre NHS Trust (C.A.Y.), Liverpool, UK; Istituti Clinici Scientifici Maugeri IRCSS (G.M.), Milan; Department of Neuroscience (J.M.), Sant'Agostino-Estense Hospital and University of Modena and Reggio Emilia, Modena; Department of Neurology (G.B.), Azienda Universitario Ospedaliera di Cagliari and University of Cagliari; Istituti Clinici Scientifici Maugeri IRCSS (P.V.), Mistretta, Italy; Rijnstate Ziekenhuis (E.V.), Arnhem, the Netherlands; Rita Levi Montalcini' Department of Neuroscience (A.C.), ALS Centre, University of Torino; and Azienda Ospedaliera Città della Salute e della Scienza (A.C.), Turin, Italy.

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http://dx.doi.org/10.1212/WNL.0000000000004606DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5664299PMC
October 2017

Amyotrophic lateral sclerosis.

Nat Rev Dis Primers 2017 Oct 5;3:17071. Epub 2017 Oct 5.

Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands.

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http://dx.doi.org/10.1038/nrdp.2017.71DOI Listing
October 2017

"Anything that makes life's journey better." Exploring the use of digital technology by people living with motor neurone disease.

Amyotroph Lateral Scler Frontotemporal Degener 2017 08 20;18(5-6):378-387. Epub 2017 Feb 20.

a Sheffield Institute for Translational Neurosciences, University of Sheffield , Sheffield , UK and.

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http://dx.doi.org/10.1080/21678421.2017.1288253DOI Listing
August 2017

Serum miRNAs miR-206, 143-3p and 374b-5p as potential biomarkers for amyotrophic lateral sclerosis (ALS).

Neurobiol Aging 2017 07 1;55:123-131. Epub 2017 Apr 1.

Department of Neuroscience, Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield, UK. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2017.03.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5455071PMC
July 2017

Comparison of the King's and MiToS staging systems for ALS.

Amyotroph Lateral Scler Frontotemporal Degener 2017 05 5;18(3-4):227-232. Epub 2017 Jan 5.

a Maurice Wohl Clinical Neuroscience Institute, Department of Basic and Clinical Neuroscience , King's College London , UK.

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http://dx.doi.org/10.1080/21678421.2016.1265565DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5425622PMC
May 2017

Protein Homeostasis in Amyotrophic Lateral Sclerosis: Therapeutic Opportunities?

Front Mol Neurosci 2017 2;10:123. Epub 2017 May 2.

Sheffield Institute for Translational Neuroscience (SITraN), Department of Neuroscience, University of SheffieldSheffield, UK.

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http://dx.doi.org/10.3389/fnmol.2017.00123DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5411428PMC
May 2017

Surgical and trauma care in low- and middle-income countries: a review of capacity assessments.

J Surg Res 2017 04 10;210:139-151. Epub 2016 Nov 10.

Department of Surgery, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.

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http://dx.doi.org/10.1016/j.jss.2016.11.005DOI Listing
April 2017

A multicentre evaluation of oropharyngeal secretion management practices in amyotrophic lateral sclerosis.

Amyotroph Lateral Scler Frontotemporal Degener 2017 02 31;18(1-2):1-9. Epub 2016 Aug 31.

a Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield, & Academic Directorate of Neurosciences, Royal Hallamshire Hospital, Sheffield Teaching Hospitals NHS Foundation Trust , Sheffield.

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http://dx.doi.org/10.1080/21678421.2016.1221433DOI Listing
February 2017

Cytokine Release Syndrome After Chimeric Antigen Receptor T Cell Therapy for Acute Lymphoblastic Leukemia.

Crit Care Med 2017 Feb;45(2):e124-e131

1Division of Critical Care Medicine, Department of Anesthesia and Critical Care, The Children's Hospital of Philadelphia and The University of Pennsylvania Perelman School of Medicine, Philadelphia, PA. 2Division of Oncology, Department of Pediatrics, The Children's Hospital of Philadelphia and The University of Pennsylvania Perelman School of Medicine, Philadelphia, PA. 3Center for Cellular Immunotherapies, Department of Pathology and Laboratory Medicine, The University of Pennsylvania Perelman School of Medicine, Philadelphia, PA. 4Department of Biostatistics and Epidemiology, The University of Pennsylvania Perelman School of Medicine, Philadelphia, PA. 5Division of Hematology-Oncology, Department of Medicine, Abramson Cancer Center, The University of Pennsylvania Perelman School of Medicine, Philadelphia, PA.

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http://dx.doi.org/10.1097/CCM.0000000000002053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5452983PMC
February 2017

The design and conduct of Keep It Off: An online randomized trial of financial incentives for weight-loss maintenance.

Clin Trials 2017 Feb 23;14(1):29-36. Epub 2016 Sep 23.

2 Center for Health Incentives and Behavioral Economics, Leonard Davis Institute of Health Economics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.1177/1740774516669679DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5300940PMC
February 2017

Mapping the evolving definitions of translational research.

J Clin Transl Sci 2017 Feb 2;1(1):60-66. Epub 2017 Feb 2.

Department of Preventive Medicine, Feinberg School of Medicine, Division of Health and Biomedical Informatics, Northwestern University, Chicago, IL, USA.

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http://dx.doi.org/10.1017/cts.2016.10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5408839PMC
February 2017

C9ORF72 interaction with cofilin modulates actin dynamics in motor neurons.

Nat Neurosci 2016 12 10;19(12):1610-1618. Epub 2016 Oct 10.

Institute of Clinical Neurobiology, University Hospital of Wuerzburg, Wuerzburg, Germany.

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http://dx.doi.org/10.1038/nn.4407DOI Listing
December 2016

"Big Data" for Breast Cancer: Where to look and what you will find.

NPJ Breast Cancer 2016 2;2. Epub 2016 Nov 2.

Biosciences & Bioinformatics Librarian, NIH Public Access Compliance Reporter (PACR), Galter Health Sciences Library, Feinberg School of Medicine, Northwestern University, 303 E. Chicago Ave., Room 1-285, Chicago, IL 60611.

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http://dx.doi.org/10.1038/npjbcancer.2016.31DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5289822PMC
November 2016

Use of administrative data to increase the practicality of clinical trials: Insights from the Women's Health Initiative.

Clin Trials 2016 10 30;13(5):519-26. Epub 2016 Jun 30.

Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, PA, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5059108PMC
http://dx.doi.org/10.1177/1740774516656579DOI Listing
October 2016

Autophagy deficiency in macrophages enhances NLRP3 inflammasome activity and chronic lung disease following silica exposure.

Toxicol Appl Pharmacol 2016 10 1;309:101-10. Epub 2016 Sep 1.

Center for Environmental Health Sciences, University of Montana, Missoula, Montana, United States. Electronic address:

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5054752PMC
http://dx.doi.org/10.1016/j.taap.2016.08.029DOI Listing
October 2016

Determinants of HIV Transmission Risk Among HIV-Infected Persons Engaged in Care.

AIDS Educ Prev 2016 10;28(5):440-452

Division of Infectious Diseases, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia.

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http://dx.doi.org/10.1521/aeap.2016.28.5.440DOI Listing
October 2016

Immune response in peripheral axons delays disease progression in SOD1 mice.

J Neuroinflammation 2016 10 7;13(1):261. Epub 2016 Oct 7.

Laboratory of Molecular Neurobiology, Department of Neuroscience, IRCCS - Istituto di Ricerche Farmacologiche Mario Negri, Via La Masa 19, 20156, Milan, Italy.

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http://dx.doi.org/10.1186/s12974-016-0732-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5055725PMC
October 2016

Prevalence and predictors of low muscle mass in HIV/viral hepatitis coinfection.

AIDS 2016 10;30(16):2519-2528

aDivision of Infectious Diseases, Department of Medicine bDepartment of Biostatistics and Epidemiology, Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania cDivision of Endocrinology, Diabetes, & Metabolism, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland dDepartment of Nutrition, University of Pennsylvania School of Nursing eDivision of Gastroenterology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania fJohn Bell Health Center, Philadelphia Field Initiating Group for HIV Trials, Philadelphia, Pennsylvania gDivision of Infectious Diseases, Department of Medicine, University of California San Francisco School of Medicine hDepartment of Medicine, San Francisco Veterans Affairs, Medical Center, San Francisco, California, USA.

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http://dx.doi.org/10.1097/QAD.0000000000001213DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5257196PMC
October 2016

Oligodendrocytes contribute to motor neuron death in ALS via SOD1-dependent mechanism.

Proc Natl Acad Sci U S A 2016 10 29;113(42):E6496-E6505. Epub 2016 Sep 29.

The Research Institute, Nationwide Children's Hospital, Columbus, OH 43205; Department of Neuroscience, The Ohio State University, Columbus, OH 43210; Molecular, Cellular, and Developmental Biology Graduate Program, The Ohio State University, Columbus, OH 43210; Integrated Biomedical Science Graduate Program, College of Medicine, The Ohio State University, Columbus, OH 43210

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http://dx.doi.org/10.1073/pnas.1607496113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5081600PMC
October 2016

NEK1 variants confer susceptibility to amyotrophic lateral sclerosis.

Nat Genet 2016 09 25;48(9):1037-42. Epub 2016 Jul 25.

Department of Neurology, University of Massachusetts Medical School, Worcester, Massachusetts, USA.

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http://dx.doi.org/10.1038/ng.3626DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5560030PMC
September 2016

Genome-wide association analyses identify new risk variants and the genetic architecture of amyotrophic lateral sclerosis.

Authors:
Wouter van Rheenen Aleksey Shatunov Annelot M Dekker Russell L McLaughlin Frank P Diekstra Sara L Pulit Rick A A van der Spek Urmo Võsa Simone de Jong Matthew R Robinson Jian Yang Isabella Fogh Perry Tc van Doormaal Gijs H P Tazelaar Max Koppers Anna M Blokhuis William Sproviero Ashley R Jones Kevin P Kenna Kristel R van Eijk Oliver Harschnitz Raymond D Schellevis William J Brands Jelena Medic Androniki Menelaou Alice Vajda Nicola Ticozzi Kuang Lin Boris Rogelj Katarina Vrabec Metka Ravnik-Glavač Blaž Koritnik Janez Zidar Lea Leonardis Leja Dolenc Grošelj Stéphanie Millecamps François Salachas Vincent Meininger Mamede de Carvalho Susana Pinto Jesus S Mora Ricardo Rojas-García Meraida Polak Siddharthan Chandran Shuna Colville Robert Swingler Karen E Morrison Pamela J Shaw John Hardy Richard W Orrell Alan Pittman Katie Sidle Pietro Fratta Andrea Malaspina Simon Topp Susanne Petri Susanne Abdulla Carsten Drepper Michael Sendtner Thomas Meyer Roel A Ophoff Kim A Staats Martina Wiedau-Pazos Catherine Lomen-Hoerth Vivianna M Van Deerlin John Q Trojanowski Lauren Elman Leo McCluskey A Nazli Basak Ceren Tunca Hamid Hamzeiy Yesim Parman Thomas Meitinger Peter Lichtner Milena Radivojkov-Blagojevic Christian R Andres Cindy Maurel Gilbert Bensimon Bernhard Landwehrmeyer Alexis Brice Christine A M Payan Safaa Saker-Delye Alexandra Dürr Nicholas W Wood Lukas Tittmann Wolfgang Lieb Andre Franke Marcella Rietschel Sven Cichon Markus M Nöthen Philippe Amouyel Christophe Tzourio Jean-François Dartigues Andre G Uitterlinden Fernando Rivadeneira Karol Estrada Albert Hofman Charles Curtis Hylke M Blauw Anneke J van der Kooi Marianne de Visser An Goris Markus Weber Christopher E Shaw Bradley N Smith Orietta Pansarasa Cristina Cereda Roberto Del Bo Giacomo P Comi Sandra D'Alfonso Cinzia Bertolin Gianni Sorarù Letizia Mazzini Viviana Pensato Cinzia Gellera Cinzia Tiloca Antonia Ratti Andrea Calvo Cristina Moglia Maura Brunetti Simona Arcuti Rosa Capozzo Chiara Zecca Christian Lunetta Silvana Penco Nilo Riva Alessandro Padovani Massimiliano Filosto Bernard Muller Robbert Jan Stuit Ian Blair Katharine Zhang Emily P McCann Jennifer A Fifita Garth A Nicholson Dominic B Rowe Roger Pamphlett Matthew C Kiernan Julian Grosskreutz Otto W Witte Thomas Ringer Tino Prell Beatrice Stubendorff Ingo Kurth Christian A Hübner P Nigel Leigh Federico Casale Adriano Chio Ettore Beghi Elisabetta Pupillo Rosanna Tortelli Giancarlo Logroscino John Powell Albert C Ludolph Jochen H Weishaupt Wim Robberecht Philip Van Damme Lude Franke Tune H Pers Robert H Brown Jonathan D Glass John E Landers Orla Hardiman Peter M Andersen Philippe Corcia Patrick Vourc'h Vincenzo Silani Naomi R Wray Peter M Visscher Paul I W de Bakker Michael A van Es R Jeroen Pasterkamp Cathryn M Lewis Gerome Breen Ammar Al-Chalabi Leonard H van den Berg Jan H Veldink

Nat Genet 2016 09 25;48(9):1043-8. Epub 2016 Jul 25.

Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, the Netherlands.

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http://dx.doi.org/10.1038/ng.3622DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5556360PMC
September 2016