Pamela S Ohashi

Pamela S Ohashi

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Pamela S Ohashi

Publications by authors named "Pamela S Ohashi"

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Expression of costimulatory and inhibitory receptors in FoxP3 regulatory T cells within the tumor microenvironment: Implications for combination immunotherapy approaches.

Adv Cancer Res 2019 6;144:193-261. Epub 2019 Jun 6.

The Campbell Family Institute for Breast Cancer Research, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada; Department of Immunology, University of Toronto, Toronto, ON, Canada. Electronic address:

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http://dx.doi.org/10.1016/bs.acr.2019.05.001DOI Listing
June 2019

In vitro-generated MART-1-specific CD8 T cells display a broader T-cell receptor repertoire than ex vivo naïve and tumor-infiltrating lymphocytes.

Immunol Cell Biol 2019 04 15;97(4):427-434. Epub 2019 Feb 15.

Biological Sciences, Sunnybrook Research Institute, Toronto, ON, Canada.

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http://dx.doi.org/10.1111/imcb.12231DOI Listing
April 2019

Turning the Tide Against Regulatory T Cells.

Front Oncol 2019 16;9:279. Epub 2019 Apr 16.

Princess Margaret Cancer Centre, Campbell Family Institute for Breast Cancer Research, University Health Network, Toronto, ON, Canada.

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http://dx.doi.org/10.3389/fonc.2019.00279DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6477083PMC
April 2019

Phase I study of local radiation and tremelimumab in patients with inoperable locally recurrent or metastatic breast cancer.

Oncotarget 2019 Apr 26;10(31):2947-2958. Epub 2019 Apr 26.

Department of Medical Oncology, Princess Margaret Cancer Centre, University Health Network, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.18632/oncotarget.26893DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6508206PMC
April 2019

ILC regulation of T cell responses in inflammatory diseases and cancer.

Semin Immunol 2019 Feb 2;41:101284. Epub 2019 Aug 2.

Princess Margaret Cancer Centre, University Health Network, University of Toronto, 610 University Ave., Toronto, Ontario, M5G 2M9, Canada; Campbell Family Institute for Breast Cancer Research, Canada; Department of Immunology, University of Toronto, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.smim.2019.101284DOI Listing
February 2019

Regulatory T Cells in Ovarian Cancer Are Characterized by a Highly Activated Phenotype Distinct from that in Melanoma.

Clin Cancer Res 2018 11 31;24(22):5685-5696. Epub 2018 Jul 31.

The Campbell Family Institute for Breast Cancer Research, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1158/1078-0432.CCR-18-0554DOI Listing
November 2018

Immunoregulatory functions of innate lymphoid cells.

J Immunother Cancer 2018 11 19;6(1):121. Epub 2018 Nov 19.

Department of Immunology, Faculty of Medicine, University of Toronto, Toronto, ON, Canada.

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https://jitc.biomedcentral.com/articles/10.1186/s40425-018-0
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http://dx.doi.org/10.1186/s40425-018-0433-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245864PMC
November 2018

Radiation and Heat Improve the Delivery and Efficacy of Nanotherapeutics by Modulating Intratumoral Fluid Dynamics.

ACS Nano 2018 08 20;12(8):7583-7600. Epub 2018 Jul 20.

Department of Medical Biophysics , University of Toronto , Toronto , ON M5G 1L7 , Canada.

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http://dx.doi.org/10.1021/acsnano.7b06301DOI Listing
August 2018

Timed Regulation of 3BP2 Induction Is Critical for Sustaining CD8 T Cell Expansion and Differentiation.

Cell Rep 2018 07;24(5):1123-1135

Princess Margaret Cancer Center, Toronto Medical Discovery Tower, Toronto, ON M5G 1L7, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON M5S 1L7, Canada; Department of Immunology, University of Toronto, Toronto, ON M5S 1L7, Canada; Department of Medicine, University of Toronto, Toronto, ON M5S 1L7, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.06.075DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6701191PMC
July 2018

Rational design and identification of immuno-oncology drug combinations.

Eur J Cancer 2018 05 7;95:38-51. Epub 2018 Apr 7.

Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre, University Health Network, University of Toronto, 610 University Ave, Toronto, Ontario, M5G 2M9, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ejca.2018.02.027DOI Listing
May 2018

International validation of the consensus Immunoscore for the classification of colon cancer: a prognostic and accuracy study.

Authors:
Franck Pagès Bernhard Mlecnik Florence Marliot Gabriela Bindea Fang-Shu Ou Carlo Bifulco Alessandro Lugli Inti Zlobec Tilman T Rau Martin D Berger Iris D Nagtegaal Elisa Vink-Börger Arndt Hartmann Carol Geppert Julie Kolwelter Susanne Merkel Robert Grützmann Marc Van den Eynde Anne Jouret-Mourin Alex Kartheuser Daniel Léonard Christophe Remue Julia Y Wang Prashant Bavi Michael H A Roehrl Pamela S Ohashi Linh T Nguyen SeongJun Han Heather L MacGregor Sara Hafezi-Bakhtiari Bradly G Wouters Giuseppe V Masucci Emilia K Andersson Eva Zavadova Michal Vocka Jan Spacek Lubos Petruzelka Bohuslav Konopasek Pavel Dundr Helena Skalova Kristyna Nemejcova Gerardo Botti Fabiana Tatangelo Paolo Delrio Gennaro Ciliberto Michele Maio Luigi Laghi Fabio Grizzi Tessa Fredriksen Bénédicte Buttard Mihaela Angelova Angela Vasaturo Pauline Maby Sarah E Church Helen K Angell Lucie Lafontaine Daniela Bruni Carine El Sissy Nacilla Haicheur Amos Kirilovsky Anne Berger Christine Lagorce Jeffrey P Meyers Christopher Paustian Zipei Feng Carmen Ballesteros-Merino Jeroen Dijkstra Carlijn van de Water Shannon van Lent-van Vliet Nikki Knijn Ana-Maria Mușină Dragos-Viorel Scripcariu Boryana Popivanova Mingli Xu Tomonobu Fujita Shoichi Hazama Nobuaki Suzuki Hiroaki Nagano Kiyotaka Okuno Toshihiko Torigoe Noriyuki Sato Tomohisa Furuhata Ichiro Takemasa Kyogo Itoh Prabhu S Patel Hemangini H Vora Birva Shah Jayendrakumar B Patel Kruti N Rajvik Shashank J Pandya Shilin N Shukla Yili Wang Guanjun Zhang Yutaka Kawakami Francesco M Marincola Paolo A Ascierto Daniel J Sargent Bernard A Fox Jérôme Galon

Lancet 2018 05 10;391(10135):2128-2139. Epub 2018 May 10.

INSERM, Laboratory of Integrative Cancer Immunology, Paris, France; Université Paris Descartes, Sorbonne Paris Cité, Paris, France; Centre de Recherche des Cordeliers, Université Pierre et Marie Curie, Sorbonne Universités, Paris, France. Electronic address:

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http://dx.doi.org/10.1016/S0140-6736(18)30789-XDOI Listing
May 2018

Glycogen Synthase Kinase-3 Modulates Cbl-b and Constrains T Cell Activation.

J Immunol 2017 12 6;199(12):4056-4065. Epub 2017 Nov 6.

The Campbell Family Institute for Breast Cancer Research, Princess Margaret Cancer Centre, Toronto, Ontario M5G 2M9, Canada;

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http://dx.doi.org/10.4049/jimmunol.1600396DOI Listing
December 2017

Notch Shapes the Innate Immunophenotype in Breast Cancer.

Cancer Discov 2017 11 8;7(11):1320-1335. Epub 2017 Aug 8.

Campbell Family Institute for Cancer Research, Ontario Cancer Institute, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1158/2159-8290.CD-17-0037DOI Listing
November 2017

Exposure to sequestered self-antigens in vivo is not sufficient for the induction of autoimmune diabetes.

PLoS One 2017 3;12(3):e0173176. Epub 2017 Mar 3.

Campbell Family Institute for Breast Cancer Research, Princess Margaret Cancer Centre, Departments of Medical Biophysics and Immunology, Toronto, Ontario, Canada.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0173176PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5336264PMC
August 2017

Molecular Pathways: Evaluating the Potential for B7-H4 as an Immunoregulatory Target.

Clin Cancer Res 2017 Jun 21;23(12):2934-2941. Epub 2017 Mar 21.

Campbell Family Institute for Breast Cancer Research, Princess Margaret Cancer Centre, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1158/1078-0432.CCR-15-2440DOI Listing
June 2017

Costimulation, a surprising connection for immunotherapy.

Science 2017 03;355(6332):1373-1374

Princess Margaret Cancer Centre, Campbell Family Institute for Breast Cancer Research, Toronto, ON, Canada.

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http://dx.doi.org/10.1126/science.aan1467DOI Listing
March 2017

An interaction between Scribble and the NADPH oxidase complex controls M1 macrophage polarization and function.

Nat Cell Biol 2016 Nov 3;18(11):1244-1252. Epub 2016 Oct 3.

Princess Margaret Cancer Center and Department of Medical Biophysics, University of Toronto, Toronto M5G 2M9, Canada.

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http://dx.doi.org/10.1038/ncb3413DOI Listing
November 2016

Zeroing in on Tumor-Reactive TILs.

Authors:
Pamela S Ohashi

Cancer Immunol Res 2016 09;4(9):719

Princess Margaret Cancer Centre, Ontario Cancer Institute, UHN, University of Toronto, Departments of Medical Biophysics and Immunology, Toronto, Canada.

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http://dx.doi.org/10.1158/2326-6066.CIR-16-0179DOI Listing
September 2016

Central tolerance: what you see is what you don't get!

Nat Immunol 2016 Feb;17(2):115-6

Campbell Family Institute for Breast Cancer Research, Princess Margaret Cancer Centre, Toronto, Canada, and the Department of Medical Biophysics and Immunology, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.1038/ni.3373DOI Listing
February 2016

miR-155 Upregulation in Dendritic Cells Is Sufficient To Break Tolerance In Vivo by Negatively Regulating SHIP1.

J Immunol 2015 Nov 7;195(10):4632-40. Epub 2015 Oct 7.

Campbell Family Institute for Breast Cancer Research, Princess Margaret Cancer Centre, Toronto, Ontario M5G 2C1, Canada; Department of Immunology, University of Toronto, University Health Network, Toronto, Ontario M5G 2C1, Canada;

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http://dx.doi.org/10.4049/jimmunol.1302941DOI Listing
November 2015

A Lymphotoxin/Type I IFN Axis Programs CD8+ T Cells To Infiltrate a Self-Tissue and Propagate Immunopathology.

J Immunol 2015 Nov 12;195(10):4650-9. Epub 2015 Oct 12.

Department of Immunology, University of Toronto, Toronto, Ontario M5S 1A8, Canada;

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http://dx.doi.org/10.4049/jimmunol.1501053DOI Listing
November 2015

B7-H4 is a positive regulator of antitumor immunity.

Oncoimmunology 2016;5(1):e1050575. Epub 2015 Jun 1.

Campbell Family Institute for Breast Cancer Research; Princess Margaret Cancer Centre; Toronto, Ontario, Canada; Department of Immunology; Department of Medical Biophysics; University of Toronto; Toronto, Ontario, Canada.

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http://dx.doi.org/10.1080/2162402X.2015.1050575DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4760282PMC
June 2015

Deficiency of the B cell-activating factor receptor results in limited CD169+ macrophage function during viral infection.

J Virol 2015 May 11;89(9):4748-59. Epub 2015 Feb 11.

Campell Family Institute for Breast Cancer Research, Princess Margaret Cancer Centre, University Health Network (UHN), Toronto, Ontario, Canada Department of Gastroenterology, Hepatology and Infectious Diseases, University of Düsseldorf, Düsseldorf, Germany Department of Molecular Medicine II, Düsseldorf, Germany

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http://dx.doi.org/10.1128/JVI.02976-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4403498PMC
May 2015

B7-H4 expression by nonhematopoietic cells in the tumor microenvironment promotes antitumor immunity.

Cancer Immunol Res 2015 Feb 19;3(2):184-95. Epub 2014 Dec 19.

Campbell Family Institute for Breast Cancer Research, Princess Margaret Cancer Centre, Toronto, Ontario, Canada. Department of Immunology, University of Toronto, Toronto, Ontario, Canada. Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1158/2326-6066.CIR-14-0113DOI Listing
February 2015

Clinical blockade of PD1 and LAG3--potential mechanisms of action.

Nat Rev Immunol 2015 Jan;15(1):45-56

Immune Therapy Program, Princess Margaret Cancer Centre, 610 University Avenue, Toronto, Ontario, M5G 2M9, Canada.

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http://dx.doi.org/10.1038/nri3790DOI Listing
January 2015

Peptide-pulsed dendritic cells have superior ability to induce immune-mediated tissue destruction compared to peptide with adjuvant.

PLoS One 2014 19;9(3):e92380. Epub 2014 Mar 19.

Campbell Family Institute for Breast Cancer Research, Princess Margaret Cancer Center, University Health Network, Toronto, Ontario, Canada; Department of Immunology, University of Toronto, Toronto, Ontario, Canada.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0092380PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3960236PMC
November 2014

Type I interferon protects antiviral CD8+ T cells from NK cell cytotoxicity.

Immunity 2014 Jun 5;40(6):949-60. Epub 2014 Jun 5.

Department of Gastroenterology, Hepatology, and Infectious Diseases, Heinrich-Heine-University Düsseldorf, Universitätsstrasse 1, 40225 Düsseldorf, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2014.05.004DOI Listing
June 2014

Toso controls encephalitogenic immune responses by dendritic cells and regulatory T cells.

Proc Natl Acad Sci U S A 2014 Jan 7;111(3):1060-5. Epub 2014 Jan 7.

The Campbell Family Cancer Research Institute, Ontario Cancer Institute, University Health Network, Toronto, ON, Canada M5G 2C1.

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http://dx.doi.org/10.1073/pnas.1323166111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3903229PMC
January 2014

Mir-155, a central modulator of T-cell responses.

Eur J Immunol 2014 Jan;44(1):11-5

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http://dx.doi.org/10.1002/eji.201343962DOI Listing
January 2014

Mobilizing and evaluating anticancer T cells: pitfalls and solutions.

Expert Rev Vaccines 2013 Nov 16;12(11):1325-40. Epub 2013 Oct 16.

Campbell Family Institute for Breast Cancer Research, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, M5G 2C1, Canada.

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http://www.tandfonline.com/doi/full/10.1586/14760584.2013.84
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http://dx.doi.org/10.1586/14760584.2013.843456DOI Listing
November 2013

Natural killer cells regulate diverse T cell responses.

Trends Immunol 2013 Jul 17;34(7):342-9. Epub 2013 Apr 17.

Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, University Health Network, Toronto, ON, Canada.

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http://dx.doi.org/10.1016/j.it.2013.03.002DOI Listing
July 2013

Shp1 regulates T cell homeostasis by limiting IL-4 signals.

J Exp Med 2013 Jul;210(7):1419-31

Campbell Family Institute for Breast Cancer Research, Princess Margaret Cancer Center, University Health Network, Toronto, ON M5G 2C1, Canada.

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http://dx.doi.org/10.1084/jem.20122239DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3698519PMC
July 2013

Molecular programming of steady-state dendritic cells: impact on autoimmunity and tumor immune surveillance.

Ann N Y Acad Sci 2013 May;1284:46-51

Campbell Family Institute for Breast Cancer Research, Princess Margaret Cancer Center, University Health Network, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1111/nyas.12114DOI Listing
May 2013

Micro-RNA 155 is required for optimal CD8+ T cell responses to acute viral and intracellular bacterial challenges.

J Immunol 2013 Feb 28;190(3):1210-6. Epub 2012 Dec 28.

Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, Toronto, Ontario M5G 2C1, Canada.

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http://dx.doi.org/10.4049/jimmunol.1202700DOI Listing
February 2013

Tumoral lymphocytic infiltration and expression of the chemokine CXCL10 in breast cancers from the Ontario Familial Breast Cancer Registry.

Clin Cancer Res 2013 Jan 4;19(2):336-46. Epub 2012 Dec 4.

Keenan Research Centre, Li Ka Shing Knowledge Institute of St. Michael's Hospital, University of Toronto, Ontario, Canada.

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http://dx.doi.org/10.1158/1078-0432.CCR-11-3314DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3548938PMC
January 2013

The NF-κB regulator MALT1 determines the encephalitogenic potential of Th17 cells.

J Clin Invest 2012 Dec 1;122(12):4698-709. Epub 2012 Nov 1.

The Campbell Family Cancer Research Institute, University Health Network, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1172/JCI63528DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3590210PMC
December 2012

The 3BP2 adapter protein is required for chemoattractant-mediated neutrophil activation.

J Immunol 2012 Sep 18;189(5):2138-50. Epub 2012 Jul 18.

Department of Immunology, University of Toronto, Toronto, Ontario M5S 148, Canada.

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http://dx.doi.org/10.4049/jimmunol.1103184DOI Listing
September 2012

Dysregulation of immune homeostasis in autoimmune diseases.

Nat Med 2012 Jan 6;18(1):42-7. Epub 2012 Jan 6.

Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

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http://www.nature.com/articles/nm.2621
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http://dx.doi.org/10.1038/nm.2621DOI Listing
January 2012

Defining the critical hurdles in cancer immunotherapy.

Authors:
Bernard A Fox Dolores J Schendel Lisa H Butterfield Steinar Aamdal James P Allison Paolo Antonio Ascierto Michael B Atkins Jirina Bartunkova Lothar Bergmann Neil Berinstein Cristina C Bonorino Ernest Borden Jonathan L Bramson Cedrik M Britten Xuetao Cao William E Carson Alfred E Chang Dainius Characiejus A Raja Choudhury George Coukos Tanja de Gruijl Robert O Dillman Harry Dolstra Glenn Dranoff Lindy G Durrant James H Finke Jerome Galon Jared A Gollob Cécile Gouttefangeas Fabio Grizzi Michele Guida Leif Håkansson Kristen Hege Ronald B Herberman F Stephen Hodi Axel Hoos Christoph Huber Patrick Hwu Kohzoh Imai Elizabeth M Jaffee Sylvia Janetzki Carl H June Pawel Kalinski Howard L Kaufman Koji Kawakami Yutaka Kawakami Ulrich Keilholtz Samir N Khleif Rolf Kiessling Beatrix Kotlan Guido Kroemer Rejean Lapointe Hyam I Levitsky Michael T Lotze Cristina Maccalli Michele Maio Jens-Peter Marschner Michael J Mastrangelo Giuseppe Masucci Ignacio Melero Cornelius Melief William J Murphy Brad Nelson Andrea Nicolini Michael I Nishimura Kunle Odunsi Pamela S Ohashi Jill O'Donnell-Tormey Lloyd J Old Christian Ottensmeier Michael Papamichail Giorgio Parmiani Graham Pawelec Enrico Proietti Shukui Qin Robert Rees Antoni Ribas Ruggero Ridolfi Gerd Ritter Licia Rivoltini Pedro J Romero Mohamed L Salem Rik J Scheper Barbara Seliger Padmanee Sharma Hiroshi Shiku Harpreet Singh-Jasuja Wenru Song Per Thor Straten Hideaki Tahara Zhigang Tian Sjoerd H van Der Burg Paul von Hoegen Ena Wang Marij Jp Welters Hauke Winter Tara Withington Jedd D Wolchok Weihua Xiao Laurence Zitvogel Heinz Zwierzina Francesco M Marincola Thomas F Gajewski Jon M Wigginton Mary L Disis

J Transl Med 2011 Dec 14;9:214. Epub 2011 Dec 14.

Earle A, Chiles Research Institute, Robert W, Franz Research Center, Providence Cancer Center, Providence Portland Medical Center, Portland, OR, USA.

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http://dx.doi.org/10.1186/1479-5876-9-214DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3338100PMC
December 2011

Nuclear factor-κB1 controls the functional maturation of dendritic cells and prevents the activation of autoreactive T cells.

Nat Med 2011 Nov 13;17(12):1663-7. Epub 2011 Nov 13.

Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, Toronto, Ontario, Canada.

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http://www.nature.com/articles/nm.2556
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http://dx.doi.org/10.1038/nm.2556DOI Listing
November 2011

Exposure to IL-15 and IL-21 enables autoreactive CD8 T cells to respond to weak antigens and cause disease in a mouse model of autoimmune diabetes.

J Immunol 2011 May 23;186(9):5131-41. Epub 2011 Mar 23.

Immunology Division, Department of Pediatrics, Faculty of Medicine and Health Sciences, University of Sherbrooke, Sherbrooke, Quebec J1H 5N4, Canada.

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http://dx.doi.org/10.4049/jimmunol.1001221DOI Listing
May 2011

Immunological perspective of self versus tumor antigens: insights from the RIP-gp model.

Immunol Rev 2011 May;241(1):164-79

Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, Toronto, ON, Canada.

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http://dx.doi.org/10.1111/j.1600-065X.2011.01014.xDOI Listing
May 2011

The Src-like adaptor protein regulates GM-CSFR signaling and monocytic dendritic cell maturation.

J Immunol 2011 Feb 10;186(4):1923-33. Epub 2011 Jan 10.

Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.4049/jimmunol.0903292DOI Listing
February 2011

Caspase 3 is not essential for the induction of anergy or multiple pathways of CD8+ T-cell death.

Eur J Immunol 2010 Dec;40(12):3372-7

Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, Toronto, ON, Canada.

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http://dx.doi.org/10.1002/eji.201040475DOI Listing
December 2010

Oxidized ATP inhibits T-cell-mediated autoimmunity.

Eur J Immunol 2010 Sep;40(9):2401-8

Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, UHN, Toronto, ON, Canada.

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http://dx.doi.org/10.1002/eji.200939838DOI Listing
September 2010

Fighting cancers from within: augmenting tumor immunity with cytokine therapy.

Trends Pharmacol Sci 2010 Aug 17;31(8):356-63. Epub 2010 Jun 17.

Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.

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http://dx.doi.org/10.1016/j.tips.2010.05.003DOI Listing
August 2010

Revised map of the human progenitor hierarchy shows the origin of macrophages and dendritic cells in early lymphoid development.

Nat Immunol 2010 Jul 13;11(7):585-93. Epub 2010 Jun 13.

Department of Stem Cell and Developmental Biology, Campbell Family Cancer Research Institute, Ontario Cancer Institute, University Health Network, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1038/ni.1889DOI Listing
July 2010

c-Rel phenocopies PKCtheta but not Bcl-10 in regulating CD8+ T-cell activation versus tolerance.

Eur J Immunol 2010 Mar;40(3):867-77

Campbell Family Institute, Ontario Cancer Institute, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1002/eji.200939445DOI Listing
March 2010

c-Rel but not NF-kappaB1 is important for T regulatory cell development.

Eur J Immunol 2010 Mar;40(3):677-81

Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, Toronto, Ont., Canada.

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http://dx.doi.org/10.1002/eji.201040298DOI Listing
March 2010

HUNK suppresses metastasis of basal type breast cancers by disrupting the interaction between PP2A and cofilin-1.

Proc Natl Acad Sci U S A 2010 Feb 22;107(6):2622-7. Epub 2010 Jan 22.

Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute at Princess Margaret Hospital, University Health Network, Toronto, ON M5G 2C1, Canada.

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http://dx.doi.org/10.1073/pnas.0914492107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2823890PMC
February 2010

Dendritic cells integrate signals from the tumor microenvironment to modulate immunity and tumor growth.

Immunol Lett 2010 Jan 22;127(2):77-84. Epub 2009 Sep 22.

Campbell Family Institute, Ontario Cancer Institute, Toronto, Ontario, Canada.

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http://linkinghub.elsevier.com/retrieve/pii/S016524780900232
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http://dx.doi.org/10.1016/j.imlet.2009.09.003DOI Listing
January 2010

Nfil3/E4bp4 is required for the development and maturation of NK cells in vivo.

J Exp Med 2009 Dec 7;206(13):2977-86. Epub 2009 Dec 7.

The Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, University Health Network, Ontario M5G 2C1, Canada.

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http://dx.doi.org/10.1084/jem.20092176DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2806474PMC
December 2009

LPS/TLR4 signal transduction pathway.

Cytokine 2008 May 4;42(2):145-151. Epub 2008 Mar 4.

The Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, 610 University Avenue, Toronto, Ont., Canada M5G 2M9; Department of Medical Biophysics, University of Toronto, Toronto, Ont., Canada M5G 2C1; Department of Immunology, University of Toronto, Toronto, Ont., Canada M5S1A8. Electronic address:

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http://dx.doi.org/10.1016/j.cyto.2008.01.006DOI Listing
May 2008

Targeting of pancreatic glia in type 1 diabetes.

Diabetes 2008 Apr 15;57(4):918-28. Epub 2008 Jan 15.

The Hospital for Sick Children, 555 University Ave., 10th Floor Elm Wing, Rm. 10126, Toronto, Ontario, M5G 1X8, Canada.

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http://dx.doi.org/10.2337/db07-0226DOI Listing
April 2008

CARD6 is interferon inducible but not involved in nucleotide-binding oligomerization domain protein signaling leading to NF-kappaB activation.

Mol Cell Biol 2008 Mar 26;28(5):1541-52. Epub 2007 Dec 26.

Campbell Family Institute for Breast Cancer Research and Ontario Cancer Institute, Toronto, Ontario M5G 2C1, Canada.

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http://dx.doi.org/10.1128/MCB.01359-07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2258768PMC
March 2008

IRAK-4 kinase activity is required for IRAK-4-dependent innate and adaptive immune responses.

Eur J Immunol 2008 Mar;38(3):870-6

The Campbell Family Institute for Breast Cancer Research, University Health Network, Toronto, Canada.

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http://dx.doi.org/10.1002/eji.200737429DOI Listing
March 2008

CD4 T cells, lymphopenia, and IL-7 in a multistep pathway to autoimmunity.

Proc Natl Acad Sci U S A 2008 Feb 14;105(8):2999-3004. Epub 2008 Feb 14.

The Campbell Family Institute for Breast Cancer Research, University Health Network, Toronto, ON, Canada.

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http://dx.doi.org/10.1073/pnas.0712135105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2268574PMC
February 2008

RIP2 contributes to Nod signaling but is not essential for T cell proliferation, T helper differentiation or TLR responses.

Eur J Immunol 2008 Jan;38(1):64-72

Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, Department of Immunology, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.1002/eji.200737393DOI Listing
January 2008