Pamela Kearns

Pamela Kearns

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Pamela Kearns

Pamela Kearns

Publications by authors named "Pamela Kearns"

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54Publications

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Targeting the arginine metabolic brake enhances immunotherapy for leukaemia.

Int J Cancer 2019 Oct 11;145(8):2201-2208. Epub 2019 Jan 11.

Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, United Kingdom.

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http://dx.doi.org/10.1002/ijc.32028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6767531PMC
October 2019

A European paediatric cancer mission: aspiration or reality?

Lancet Oncol 2019 Sep;20(9):1200-1202

Department of Pediatrics and Adolescent Medicine, Rigshospitalet University Hospital, and Institute of Clinical Medicine, Faculty of Medicine, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.1016/S1470-2045(19)30487-5DOI Listing
September 2019

Long-term analysis of children with metastatic neuroblastoma treated in the ENSG5 randomised clinical trial.

Pediatr Blood Cancer 2019 04 5;66(4):e27565. Epub 2018 Dec 5.

Children and Young People's Unit, The Royal Marsden NHS Foundation Trust, Sutton, United Kingdom (retired).

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http://doi.wiley.com/10.1002/pbc.27565
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http://dx.doi.org/10.1002/pbc.27565DOI Listing
April 2019

Synergistic action of dual IGF1/R and MEK inhibition sensitizes childhood acute lymphoblastic leukemia (ALL) cells to cytotoxic agents and involves downregulation of STAT6 and PDAP1.

Exp Hematol 2018 07 12;63:52-63.e5. Epub 2018 Apr 12.

Institute of Cancer and Genomic Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK. Electronic address:

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http://dx.doi.org/10.1016/j.exphem.2018.04.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371922PMC
July 2018

Dasatinib in Pediatric Patients With Chronic Myeloid Leukemia in Chronic Phase: Results From a Phase II Trial.

J Clin Oncol 2018 05 2;36(13):1330-1338. Epub 2018 Mar 2.

Lia Gore, University of Colorado School of Medicine/Children's Hospital Colorado, Aurora, CO; Pamela R. Kearns, University of Birmingham, Birmingham, West Midlands; Donna Lancaster, Royal Marsden Hospital, Sutton, Surrey, United Kingdom; Maria Lucia de Martino Lee, Support Group for Children and Adolescents with Cancer; Carmino Antonio De Souza, University of Campinas, São Paulo, Brazil; Yves Bertrand, L'Institut d'Hématologie et d'Oncologie Pédiatrique, Lyon, France; Nobuko Hijiya, Ann and Robert H. Lurie Children's Hospital of Chicago, and Northwestern University Feinberg School of Medicine, Chicago, IL; Linda C. Stork, Oregon Health & Science University, Portland, OR; Nack-Gyun Chung, The Catholic University of Korea, Seoul St. Mary's Hospital; Jong Jin Seo, University of Ulsan College of Medicine, and Asan Medical Center, Seoul, Republic of Korea; Rocio Cardenas Cardos, Instituto Nacional De Pediatria, Mexico City, Mexico; Tapan Saikia, Prince Aly Khan Hospital, Mumbai, India; Franca Fagioli, Regina Margherita Hospital, Turin, Italy; Judith Landman-Parker, Hôpital Enfants Armand-Trousseau, Paris, France; Andrew E. Place, Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, MA; Karen R. Rabin, Texas Children's Cancer Center, and Baylor College of Medicine, Houston, TX; Mariana Sacchi and Rene Swanink, Bristol-Myers Squibb, Princeton, NJ; C. Michel Zwaan, Erasmus MC-Sophia Children's Hospital, Rotterdam, Netherlands; Pamela R. Kearns and C. Michel Zwaan, Innovative Therapies for Children with Cancer Consortium, European Union.

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http://dx.doi.org/10.1200/JCO.2017.75.9597DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5929218PMC
May 2018

10-year report on the European Paediatric Regulation and its impact on new drugs for children's cancers.

Lancet Oncol 2018 03;19(3):285-287

Innovative Therapy for Children with Cancer, Europe; SIOPE Brussels, Belgium; Department of Clinical Research, Gustave Roussy, Paris-Saclay University, Villejuif, France.

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http://dx.doi.org/10.1016/S1470-2045(18)30105-0DOI Listing
March 2018

The development of targeted new agents to improve the outcome for children with leukemia.

Expert Opin Drug Discov 2016 Nov 27;11(11):1111-1122. Epub 2016 Sep 27.

a Department of Pediatric Oncology, Hematology and Stem Cell Transplantation , Hospital Niño Jesús , Madrid , Spain.

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http://dx.doi.org/10.1080/17460441.2016.1237939DOI Listing
November 2016

The ability to cross the blood-cerebrospinal fluid barrier is a generic property of acute lymphoblastic leukemia blasts.

Blood 2016 Apr 11;127(16):1998-2006. Epub 2016 Feb 11.

Wolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, College of Medical, Veterinary, and Life Sciences, University of Glasgow, Glasgow, United Kingdom; and Department of Paediatric Haematology, Royal Hospital for Children, Glasgow, United Kingdom.

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http://dx.doi.org/10.1182/blood-2015-08-665034DOI Listing
April 2016

Adjunctive Treatment in Juvenile Nasopharyngeal Angiofibroma: How Should We Approach Recurrence?

J Pediatr Hematol Oncol 2016 Apr;38(3):235-9

*ENT Department, Whipps Cross Hospital, London †Department of Pathology ‡ENT Department, Birmingham Children's Hospital §School of Cancer Sciences, University of Birmingham ∥Paediatric Oncology Department, Birmingham Children's Hospital, Birmingham, UK.

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http://pdfs.journals.lww.com/jpho-online/2016/04000/Adjuncti
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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
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http://dx.doi.org/10.1097/MPH.0000000000000524DOI Listing
April 2016

Challenges of clinical trial design for targeted agents against pediatric leukemias.

Front Oncol 2014 6;4:374. Epub 2015 Jan 6.

Cancer Research UK Clinical Trials Unit, School of Cancer Sciences, University of Birmingham , Birmingham , UK.

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http://dx.doi.org/10.3389/fonc.2014.00374DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4285052PMC
January 2015

Comparison of anticipated and actual control group outcomes in randomised trials in paediatric oncology provides evidence that historically controlled studies are biased in favour of the novel treatment.

Trials 2014 Dec 10;15:481. Epub 2014 Dec 10.

Cancer Research UK Clinical Trials Unit, School of Cancer Sciences, University of Birmingham, Vincent Drive, Edgbaston, Birmingham B15 2TT, UK.

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http://dx.doi.org/10.1186/1745-6215-15-481DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4295234PMC
December 2014

Sequential treatment with cytarabine and decitabine has an increased anti-leukemia effect compared to cytarabine alone in xenograft models of childhood acute myeloid leukemia.

PLoS One 2014 28;9(1):e87475. Epub 2014 Jan 28.

Cancer Research UK Clinical Trials Unit, School of Cancer Sciences, University of Birmingham, Edgbaston, Birmingham, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0087475PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3905025PMC
November 2014

Long-term retinoblastoma follow-up with or without general anaesthesia.

Pediatr Blood Cancer 2014 Feb 4;61(2):260-4. Epub 2013 Sep 4.

Birmingham Children's Hospital, Birmingham, UK.

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http://dx.doi.org/10.1002/pbc.24755DOI Listing
February 2014

New drug development in childhood cancer.

Curr Opin Pediatr 2014 Feb;26(1):37-42

aUniversity of Birmingham bBirmingham Children's Hospital, Birmingham, West Midlands, UK.

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http://dx.doi.org/10.1097/MOP.0000000000000054DOI Listing
February 2014

The EBV oncogene LMP1 protects lymphoma cells from cell death through the collagen-mediated activation of DDR1.

Blood 2013 Dec 17;122(26):4237-45. Epub 2013 Oct 17.

School of Cancer Sciences, University of Birmingham, Birmingham, United Kingdom; and.

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http://dx.doi.org/10.1182/blood-2013-04-499004DOI Listing
December 2013

The need for proportionate regulation of clinical trials.

Authors:
Pamela Kearns

Lancet Oncol 2013 May 21;14(6):454-5. Epub 2013 Mar 21.

Cancer Research UK Clinical Trials Unit, School of Cancer Sciences, University of Birmingham, Birmingham B15 2TT, UK.

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http://dx.doi.org/10.1016/S1470-2045(13)70077-9DOI Listing
May 2013

Intra-abdominal Kaposiform hemangioendothelioma and the benefits of laparoscopic surveillance.

Pediatr Blood Cancer 2012 Jun 26;58(6):992-3. Epub 2011 Aug 26.

Department of Paediatric Surgery, Birmingham Children's Hospital, Birmingham, UK.

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http://dx.doi.org/10.1002/pbc.23309DOI Listing
June 2012

PEPtalk: postexposure prophylaxis against varicella in children with cancer.

Arch Dis Child 2011 Sep 28;96(9):841-5. Epub 2011 Jun 28.

Division of Clinical Sciences, St George's, University of London, London, UK.

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http://dx.doi.org/10.1136/adc.2010.209650DOI Listing
September 2011

The contribution of the Epstein-Barr virus to the pathogenesis of childhood lymphomas.

Cancer Treat Rev 2010 Jun 2;36(4):348-53. Epub 2010 Mar 2.

Cancer Research UK Institute for Cancer Studies, University of Birmingham, UK.

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http://dx.doi.org/10.1016/j.ctrv.2010.02.011DOI Listing
June 2010

The role of the 'innovative therapies for children with cancer' (ITCC) European consortium.

Cancer Treat Rev 2010 Jun 15;36(4):328-34. Epub 2010 Mar 15.

Dept. of Ped Oncology/Hematology, Erasmus MC/Sophia Children's Hospital, GJ Rotterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.ctrv.2010.02.008DOI Listing
June 2010

Expression of CD133 on leukemia-initiating cells in childhood ALL.

Blood 2009 Apr 15;113(14):3287-96. Epub 2009 Jan 15.

Bristol Institute for Transfusion Sciences, Bristol, United Kingdom.

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http://www.bloodjournal.org/content/113/14/3287.full.pdf
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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2008-04-15
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http://dx.doi.org/10.1182/blood-2008-04-154187DOI Listing
April 2009

Characterization of a progenitor cell population in childhood T-cell acute lymphoblastic leukemia.

Blood 2007 Jan 26;109(2):674-82. Epub 2006 Sep 26.

Bristol Institute for Transfusion Sciences, University of Bristol, BS10 5ND, United Kingdom.

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http://www.bloodjournal.org/content/109/2/674.full.pdf
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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2006-06-03
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http://dx.doi.org/10.1182/blood-2006-06-030445DOI Listing
January 2007

Potential clinical impact of taking multiple blood samples for research studies in paediatric oncology: how much do we really know?

Pediatr Blood Cancer 2006 Jun;46(7):723-7

Northern Institute for Cancer Research, University of Newcastle upon Tyne, Newcastle upon Tyne, United Kingdom.

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http://dx.doi.org/10.1002/pbc.20463DOI Listing
June 2006

Mu class glutathione S-transferase mRNA isoform expression in acute lymphoblastic leukaemia.

Br J Haematol 2003 Jan;120(1):80-8

Department of Paediatric Oncology, University of Bristol, UK.

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http://dx.doi.org/10.1046/j.1365-2141.2003.04039.xDOI Listing
January 2003