Publications by authors named "Pamela J McLean"

79Publications

Detection of Extracellular Adenosine Triphosphate in a Mouse Model of Traumatic Brain Injury.

J Neurotrauma 2020 Oct 19. Epub 2020 Oct 19.

Department of Neuroscience, Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic College of Medicine, Mayo Clinic, Jacksonville, Florida, USA.

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http://dx.doi.org/10.1089/neu.2020.7226DOI Listing
October 2020

Screening non-MAPT genes of the Chr17q21 H1 haplotype in Parkinson's disease.

Parkinsonism Relat Disord 2020 Aug 1;78:138-144. Epub 2020 Aug 1.

Department of Neuroscience, Mayo Clinic, Jacksonville, FL, 32224, USA; Department of Clinical Genomics, Mayo Clinic, Jacksonville, FL, 32224, USA; School of Medicine and Medical Science, University College Dublin, Dublin, Ireland; Neuroscience PhD Program, Mayo Clinic Graduate School of Biomedical Sciences, USA; Department of Biology, College of Arts and Sciences, University of North Florida, Jacksonville, FL, 32224, USA. Electronic address:

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http://dx.doi.org/10.1016/j.parkreldis.2020.07.022DOI Listing
August 2020

Alpha-synuclein-induced mitochondrial dysfunction is mediated via a sirtuin 3-dependent pathway.

Mol Neurodegener 2020 01 13;15(1). Epub 2020 Jan 13.

Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL, 32224, USA.

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http://dx.doi.org/10.1186/s13024-019-0349-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6956494PMC
January 2020

Cellular models of alpha-synuclein toxicity and aggregation.

J Neurochem 2019 09 30;150(5):566-576. Epub 2019 Jul 30.

Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA.

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http://dx.doi.org/10.1111/jnc.14806DOI Listing
September 2019

Bimolecular Fluorescence Complementation of Alpha-synuclein Demonstrates its Oligomerization with Dopaminergic Phenotype in Mice.

EBioMedicine 2018 Mar 31;29:13-22. Epub 2018 Jan 31.

MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, USA; Shanghai Huashan Hospital, Fudan University, Shanghai, China. Electronic address:

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http://dx.doi.org/10.1016/j.ebiom.2018.01.035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5925445PMC
March 2018

Impaired endo-lysosomal membrane integrity accelerates the seeding progression of α-synuclein aggregates.

Sci Rep 2017 08 9;7(1):7690. Epub 2017 Aug 9.

Department of Neuroscience, Mayo Clinic, Jacksonville, FL, 32224, USA.

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http://dx.doi.org/10.1038/s41598-017-08149-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5550496PMC
August 2017

Neonatal AAV delivery of alpha-synuclein induces pathology in the adult mouse brain.

Acta Neuropathol Commun 2017 06 23;5(1):51. Epub 2017 Jun 23.

Department of Neuroscience, Mayo Clinic, 4500 San Pablo Rd, Jacksonville, FL, 32224, USA.

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http://dx.doi.org/10.1186/s40478-017-0455-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5481919PMC
June 2017

Histones facilitate α-synuclein aggregation during neuronal apoptosis.

Acta Neuropathol 2017 04 21;133(4):547-558. Epub 2016 Dec 21.

Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL, 32224, USA.

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http://dx.doi.org/10.1007/s00401-016-1660-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5350017PMC
April 2017

Commentary: alpha-synuclein interacts with SOD1 and promotes its oligomerization.

J Neurol Neuromedicine 2016 ;1(7):28-30

Department of Neurology, Ulm University, Albert-Einstein-Allee 11, 89081 Ulm, Germany.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5108581PMC
http://dx.doi.org/10.29245/2572.942x/2016/7.1065DOI Listing
January 2016

The neural chaperone proSAAS blocks α-synuclein fibrillation and neurotoxicity.

Proc Natl Acad Sci U S A 2016 08 25;113(32):E4708-15. Epub 2016 Jul 25.

School of Medicine, University of Maryland, Baltimore, MD 21201;

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http://dx.doi.org/10.1073/pnas.1601091113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4987805PMC
August 2016

Intracellular formation of α-synuclein oligomers and the effect of heat shock protein 70 characterized by confocal single particle spectroscopy.

Biochem Biophys Res Commun 2016 08 7;477(1):76-82. Epub 2016 Jun 7.

Center for Neuropathology and Prion Research, Ludwig-Maximilians-University, Feodor-Lynen-Str. 23, 81377 Munich, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2016.06.023DOI Listing
August 2016

Proaggregant nuclear factor(s) trigger rapid formation of α-synuclein aggregates in apoptotic neurons.

Acta Neuropathol 2016 07 2;132(1):77-91. Epub 2016 Feb 2.

Neuropathology Laboratory, Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL, 32224, USA.

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http://dx.doi.org/10.1007/s00401-016-1542-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4911378PMC
July 2016

A Rapid, Semi-Quantitative Assay to Screen for Modulators of Alpha-Synuclein Oligomerization Ex vivo.

Front Neurosci 2015 19;9:511. Epub 2016 Jan 19.

Department of Neuroscience, Mayo ClinicJacksonville, FL, USA; Mayo Graduate School, Mayo ClinicJacksonville, FL, USA.

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http://dx.doi.org/10.3389/fnins.2015.00511DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4717311PMC
February 2016

α-synuclein interacts with SOD1 and promotes its oligomerization.

Mol Neurodegener 2015 Dec 8;10:66. Epub 2015 Dec 8.

Department of Neurology, Ulm University, Albert-Einstein-Allee 11, 89081, Ulm, Germany.

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http://dx.doi.org/10.1186/s13024-015-0062-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4672499PMC
December 2015

Transmission of Soluble and Insoluble α-Synuclein to Mice.

J Neuropathol Exp Neurol 2015 Dec;74(12):1158-69

From the Department of Neuroscience (DRJ, MD, ATB, MD, MEM, DWD, PJM) and Mayo Graduate School (PJM), Mayo Clinic, Jacksonville, Florida.

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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
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http://dx.doi.org/10.1097/NEN.0000000000000262DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4654695PMC
December 2015

Untangling a role for tau in synucleinopathies.

Biol Psychiatry 2015 Nov;78(10):666-7

Department of Neuroscience, Mayo Clinic, Jacksonville, Florida. Electronic address:

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http://dx.doi.org/10.1016/j.biopsych.2015.08.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5127588PMC
November 2015

Biomarkers in Parkinson's disease: Advances and strategies.

Parkinsonism Relat Disord 2016 Jan 30;22 Suppl 1:S106-10. Epub 2015 Sep 30.

Department of Neurology, Mayo Clinic, Jacksonville, FL 32224, USA. Electronic address:

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http://dx.doi.org/10.1016/j.parkreldis.2015.09.048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5120398PMC
January 2016

Role for the microtubule-associated protein tau variant p.A152T in risk of α-synucleinopathies.

Neurology 2015 Nov 2;85(19):1680-6. Epub 2015 Sep 2.

From the Departments of Neuroscience (C.L., K.O., O.L.-B., A.I.S.-O., R.L.W., S.R., M.E.M., P.J.M., R.R., N.E.-T., D.W.D., O.A.R.), Neurology (S.F., N.E.-T., N.R.G.-R., R.J.U., Z.K.W.), and Psychiatry and Psychology (T.J.F.), Division of Biomedical Statistics and Informatics (M.G.H.), and Mayo Graduate School (P.J.M., O.A.R.), Mayo Clinic, Jacksonville, FL; Dublin Neurological Institute at the Mater Misericordiae University Hospital (A.M., T.L.), Conway; Institute of Biomolecular & Biomedical Research (A.M., T.L.), University College Dublin, Ireland; Department of Clinical Sciences (A.P.), Lund University, and Department of Neurology, Skåne University Hospital, Sweden; Department of Neurology (J.S., G.O.), Medical University of Silesia, Katowice; Department of Neurology (M.R., A.K.-W.), Jagiellonian University, Krakow; Department of Neurodegenerative Disorders (M.B.), Medical Research Centre, Polish Academy of Sciences, Warsaw; Department of Neurology (K.C.), Central Hospital of the Ministry of Interior and Administration, Warsaw, Poland; Lviv Regional Clinical Hospital (Y.S.), Ukraine; Department of Neurology and School of Medicine (I.R.), Central European Institute of Technology, Masaryk University, Brno, Czech Republic; Departments of Neurology (A.H., J.E.A., B.F.B., R.C.P.) and Pathology and Laboratory Medicine (J.E.P.), Mayo Clinic, Rochester, MN; Department of Neurology (D.M.M.), NorthShore University Health System, Evanston, IL; and Department of Neurology (C.H.A.), Mayo Clinic, Scottsdale, AZ.

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http://dx.doi.org/10.1212/WNL.0000000000001946DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4653108PMC
November 2015

Targeting α-synuclein oligomers by protein-fragment complementation for drug discovery in synucleinopathies.

Expert Opin Ther Targets 2015 May 18;19(5):589-603. Epub 2015 Mar 18.

Mayo Clinic Florida, Neuroscience , 4500 San Pablo road, Jacksonville, 32224, FL , USA

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http://dx.doi.org/10.1517/14728222.2015.1009448DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4608017PMC
May 2015

Extracellular ATP induces intracellular alpha-synuclein accumulation via P2X1 receptor-mediated lysosomal dysfunction.

Neurobiol Aging 2015 Feb 5;36(2):1209-20. Epub 2014 Nov 5.

Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA; Mayo Graduate School, Mayo Clinic, Jacksonville, FL, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2014.10.037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4315767PMC
February 2015

Alpha-synuclein and tau: teammates in neurodegeneration?

Mol Neurodegener 2014 Oct 29;9:43. Epub 2014 Oct 29.

Mayo Clinic Jacksonville, 4500 San Pablo Road, Jacksonville, FL 32224, USA.

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http://dx.doi.org/10.1186/1750-1326-9-43DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4230508PMC
October 2014

α-synuclein multimers cluster synaptic vesicles and attenuate recycling.

Curr Biol 2014 Oct 25;24(19):2319-26. Epub 2014 Sep 25.

Department of Pathology, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA; Department of Neurosciences, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cub.2014.08.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4190006PMC
October 2014

Direct visualization of CHIP-mediated degradation of alpha-synuclein in vivo: implications for PD therapeutics.

PLoS One 2014 24;9(3):e92098. Epub 2014 Mar 24.

MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, United States of America; Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0092098PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3963877PMC
January 2015

Direct detection of alpha synuclein oligomers in vivo.

Acta Neuropathol Commun 2013 May 9;1. Epub 2013 May 9.

MassGeneral Institute for Neurodegenerative Disease, Department Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1186/2051-5960-1-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3776213PMC
May 2013

Development and screening of contrast agents for in vivo imaging of Parkinson's disease.

Mol Imaging Biol 2013 Oct;15(5):585-95

MassGeneral Institute of Neurodegenerative Disease, Massachusetts General Hospital, 114 16th Street, Charlestown, MA, 02129, USA.

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http://dx.doi.org/10.1007/s11307-013-0634-yDOI Listing
October 2013

α-Synuclein oligomers and clinical implications for Parkinson disease.

Ann Neurol 2013 Feb 7;73(2):155-69. Epub 2012 Dec 7.

Morton and Gloria Shulman Movement Disorders Centre and Edmond J. Safra Program in Parkinson's Disease, Toronto Western Hospital, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/ana.23746DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3608838PMC
February 2013

Guidelines for the use and interpretation of assays for monitoring autophagy.

Authors:
Daniel J Klionsky Fabio C Abdalla Hagai Abeliovich Robert T Abraham Abraham Acevedo-Arozena Khosrow Adeli Lotta Agholme Maria Agnello Patrizia Agostinis Julio A Aguirre-Ghiso Hyung Jun Ahn Ouardia Ait-Mohamed Slimane Ait-Si-Ali Takahiko Akematsu Shizuo Akira Hesham M Al-Younes Munir A Al-Zeer Matthew L Albert Roger L Albin Javier Alegre-Abarrategui Maria Francesca Aleo Mehrdad Alirezaei Alexandru Almasan Maylin Almonte-Becerril Atsuo Amano Ravi Amaravadi Shoba Amarnath Amal O Amer Nathalie Andrieu-Abadie Vellareddy Anantharam David K Ann Shailendra Anoopkumar-Dukie Hiroshi Aoki Nadezda Apostolova Giuseppe Arancia John P Aris Katsuhiko Asanuma Nana Y O Asare Hisashi Ashida Valerie Askanas David S Askew Patrick Auberger Misuzu Baba Steven K Backues Eric H Baehrecke Ben A Bahr Xue-Yuan Bai Yannick Bailly Robert Baiocchi Giulia Baldini Walter Balduini Andrea Ballabio Bruce A Bamber Edward T W Bampton Gábor Bánhegyi Clinton R Bartholomew Diane C Bassham Robert C Bast Henri Batoko Boon-Huat Bay Isabelle Beau Daniel M Béchet Thomas J Begley Christian Behl Christian Behrends Soumeya Bekri Bryan Bellaire Linda J Bendall Luca Benetti Laura Berliocchi Henri Bernardi Francesca Bernassola Sébastien Besteiro Ingrid Bhatia-Kissova Xiaoning Bi Martine Biard-Piechaczyk Janice S Blum Lawrence H Boise Paolo Bonaldo David L Boone Beat C Bornhauser Karina R Bortoluci Ioannis Bossis Frédéric Bost Jean-Pierre Bourquin Patricia Boya Michaël Boyer-Guittaut Peter V Bozhkov Nathan R Brady Claudio Brancolini Andreas Brech Jay E Brenman Ana Brennand Emery H Bresnick Patrick Brest Dave Bridges Molly L Bristol Paul S Brookes Eric J Brown John H Brumell Nicola Brunetti-Pierri Ulf T Brunk Dennis E Bulman Scott J Bultman Geert Bultynck Lena F Burbulla Wilfried Bursch Jonathan P Butchar Wanda Buzgariu Sergio P Bydlowski Ken Cadwell Monika Cahová Dongsheng Cai Jiyang Cai Qian Cai Bruno Calabretta Javier Calvo-Garrido Nadine Camougrand Michelangelo Campanella Jenny Campos-Salinas Eleonora Candi Lizhi Cao Allan B Caplan Simon R Carding Sandra M Cardoso Jennifer S Carew Cathleen R Carlin Virginie Carmignac Leticia A M Carneiro Serena Carra Rosario A Caruso Giorgio Casari Caty Casas Roberta Castino Eduardo Cebollero Francesco Cecconi Jean Celli Hassan Chaachouay Han-Jung Chae Chee-Yin Chai David C Chan Edmond Y Chan Raymond Chuen-Chung Chang Chi-Ming Che Ching-Chow Chen Guang-Chao Chen Guo-Qiang Chen Min Chen Quan Chen Steve S-L Chen WenLi Chen Xi Chen Xiangmei Chen Xiequn Chen Ye-Guang Chen Yingyu Chen Yongqiang Chen Yu-Jen Chen Zhixiang Chen Alan Cheng Christopher H K Cheng Yan Cheng Heesun Cheong Jae-Ho Cheong Sara Cherry Russ Chess-Williams Zelda H Cheung Eric Chevet Hui-Ling Chiang Roberto Chiarelli Tomoki Chiba Lih-Shen Chin Shih-Hwa Chiou Francis V Chisari Chi Hin Cho Dong-Hyung Cho Augustine M K Choi DooSeok Choi Kyeong Sook Choi Mary E Choi Salem Chouaib Divaker Choubey Vinay Choubey Charleen T Chu Tsung-Hsien Chuang Sheau-Huei Chueh Taehoon Chun Yong-Joon Chwae Mee-Len Chye Roberto Ciarcia Maria R Ciriolo Michael J Clague Robert S B Clark Peter G H Clarke Robert Clarke Patrice Codogno Hilary A Coller María I Colombo Sergio Comincini Maria Condello Fabrizio Condorelli Mark R Cookson Graham H Coombs Isabelle Coppens Ramon Corbalan Pascale Cossart Paola Costelli Safia Costes Ana Coto-Montes Eduardo Couve Fraser P Coxon James M Cregg José L Crespo Marianne J Cronjé Ana Maria Cuervo Joseph J Cullen Mark J Czaja Marcello D'Amelio Arlette Darfeuille-Michaud Lester M Davids Faith E Davies Massimo De Felici John F de Groot Cornelis A M de Haan Luisa De Martino Angelo De Milito Vincenzo De Tata Jayanta Debnath Alexei Degterev Benjamin Dehay Lea M D Delbridge Francesca Demarchi Yi Zhen Deng Jörn Dengjel Paul Dent Donna Denton Vojo Deretic Shyamal D Desai Rodney J Devenish Mario Di Gioacchino Gilbert Di Paolo Chiara Di Pietro Guillermo Díaz-Araya Inés Díaz-Laviada Maria T Diaz-Meco Javier Diaz-Nido Ivan Dikic Savithramma P Dinesh-Kumar Wen-Xing Ding Clark W Distelhorst Abhinav Diwan Mojgan Djavaheri-Mergny Svetlana Dokudovskaya Zheng Dong Frank C Dorsey Victor Dosenko James J Dowling Stephen Doxsey Marlène Dreux Mark E Drew Qiuhong Duan Michel A Duchosal Karen Duff Isabelle Dugail Madeleine Durbeej Michael Duszenko Charles L Edelstein Aimee L Edinger Gustavo Egea Ludwig Eichinger N Tony Eissa Suhendan Ekmekcioglu Wafik S El-Deiry Zvulun Elazar Mohamed Elgendy Lisa M Ellerby Kai Er Eng Anna-Mart Engelbrecht Simone Engelender Jekaterina Erenpreisa Ricardo Escalante Audrey Esclatine Eeva-Liisa Eskelinen Lucile Espert Virginia Espina Huizhou Fan Jia Fan Qi-Wen Fan Zhen Fan Shengyun Fang Yongqi Fang Manolis Fanto Alessandro Fanzani Thomas Farkas Jean-Claude Farré Mathias Faure Marcus Fechheimer Carl G Feng Jian Feng Qili Feng Youji Feng László Fésüs Ralph Feuer Maria E Figueiredo-Pereira Gian Maria Fimia Diane C Fingar Steven Finkbeiner Toren Finkel Kim D Finley Filomena Fiorito Edward A Fisher Paul B Fisher Marc Flajolet Maria L Florez-McClure Salvatore Florio Edward A Fon Francesco Fornai Franco Fortunato Rati Fotedar Daniel H Fowler Howard S Fox Rodrigo Franco Lisa B Frankel Marc Fransen José M Fuentes Juan Fueyo Jun Fujii Kozo Fujisaki Eriko Fujita Mitsunori Fukuda Ruth H Furukawa Matthias Gaestel Philippe Gailly Malgorzata Gajewska Brigitte Galliot Vincent Galy Subramaniam Ganesh Barry Ganetzky Ian G Ganley Fen-Biao Gao George F Gao Jinming Gao Lorena Garcia Guillermo Garcia-Manero Mikel Garcia-Marcos Marjan Garmyn Andrei L Gartel Evelina Gatti Mathias Gautel Thomas R Gawriluk Matthew E Gegg Jiefei Geng Marc Germain Jason E Gestwicki David A Gewirtz Saeid Ghavami Pradipta Ghosh Anna M Giammarioli Alexandra N Giatromanolaki Spencer B Gibson Robert W Gilkerson Michael L Ginger Henry N Ginsberg Jakub Golab Michael S Goligorsky Pierre Golstein Candelaria Gomez-Manzano Ebru Goncu Céline Gongora Claudio D Gonzalez Ramon Gonzalez Cristina González-Estévez Rosa Ana González-Polo Elena Gonzalez-Rey Nikolai V Gorbunov Sharon Gorski Sandro Goruppi Roberta A Gottlieb Devrim Gozuacik Giovanna Elvira Granato Gary D Grant Kim N Green Aleš Gregorc Frédéric Gros Charles Grose Thomas W Grunt Philippe Gual Jun-Lin Guan Kun-Liang Guan Sylvie M Guichard Anna S Gukovskaya Ilya Gukovsky Jan Gunst Asa B Gustafsson Andrew J Halayko Amber N Hale Sandra K Halonen Maho Hamasaki Feng Han Ting Han Michael K Hancock Malene Hansen Hisashi Harada Masaru Harada Stefan E Hardt J Wade Harper Adrian L Harris James Harris Steven D Harris Makoto Hashimoto Jeffrey A Haspel Shin-ichiro Hayashi Lori A Hazelhurst Congcong He You-Wen He Marie-Joseé Hébert Kim A Heidenreich Miep H Helfrich Gudmundur V Helgason Elizabeth P Henske Brian Herman Paul K Herman Claudio Hetz Sabine Hilfiker Joseph A Hill Lynne J Hocking Paul Hofman Thomas G Hofmann Jörg Höhfeld Tessa L Holyoake Ming-Huang Hong David A Hood Gökhan S Hotamisligil Ewout J Houwerzijl Maria Høyer-Hansen Bingren Hu Chien-An A Hu Hong-Ming Hu Ya Hua Canhua Huang Ju Huang Shengbing Huang Wei-Pang Huang Tobias B Huber Won-Ki Huh Tai-Ho Hung Ted R Hupp Gang Min Hur James B Hurley Sabah N A Hussain Patrick J Hussey Jung Jin Hwang Seungmin Hwang Atsuhiro Ichihara Shirin Ilkhanizadeh Ken Inoki Takeshi Into Valentina Iovane Juan L Iovanna Nancy Y Ip Yoshitaka Isaka Hiroyuki Ishida Ciro Isidoro Ken-ichi Isobe Akiko Iwasaki Marta Izquierdo Yotaro Izumi Panu M Jaakkola Marja Jäättelä George R Jackson William T Jackson Bassam Janji Marina Jendrach Ju-Hong Jeon Eui-Bae Jeung Hong Jiang Hongchi Jiang Jean X Jiang Ming Jiang Qing Jiang Xuejun Jiang Xuejun Jiang Alberto Jiménez Meiyan Jin Shengkan Jin Cheol O Joe Terje Johansen Daniel E Johnson Gail V W Johnson Nicola L Jones Bertrand Joseph Suresh K Joseph Annie M Joubert Gábor Juhász Lucienne Juillerat-Jeanneret Chang Hwa Jung Yong-Keun Jung Kai Kaarniranta Allen Kaasik Tomohiro Kabuta Motoni Kadowaki Katarina Kagedal Yoshiaki Kamada Vitaliy O Kaminskyy Harm H Kampinga Hiromitsu Kanamori Chanhee Kang Khong Bee Kang Kwang Il Kang Rui Kang Yoon-A Kang Tomotake Kanki Thirumala-Devi Kanneganti Haruo Kanno Anumantha G Kanthasamy Arthi Kanthasamy Vassiliki Karantza Gur P Kaushal Susmita Kaushik Yoshinori Kawazoe Po-Yuan Ke John H Kehrl Ameeta Kelekar Claus Kerkhoff David H Kessel Hany Khalil Jan A K W Kiel Amy A Kiger Akio Kihara Deok Ryong Kim Do-Hyung Kim Dong-Hou Kim Eun-Kyoung Kim Hyung-Ryong Kim Jae-Sung Kim Jeong Hun Kim Jin Cheon Kim John K Kim Peter K Kim Seong Who Kim Yong-Sun Kim Yonghyun Kim Adi Kimchi Alec C Kimmelman Jason S King Timothy J Kinsella Vladimir Kirkin Lorrie A Kirshenbaum Katsuhiko Kitamoto Kaio Kitazato Ludger Klein Walter T Klimecki Jochen Klucken Erwin Knecht Ben C B Ko Jan C Koch Hiroshi Koga Jae-Young Koh Young Ho Koh Masato Koike Masaaki Komatsu Eiki Kominami Hee Jeong Kong Wei-Jia Kong Viktor I Korolchuk Yaichiro Kotake Michael I Koukourakis Juan B Kouri Flores Attila L Kovács Claudine Kraft Dimitri Krainc Helmut Krämer Carole Kretz-Remy Anna M Krichevsky Guido Kroemer Rejko Krüger Oleg Krut Nicholas T Ktistakis Chia-Yi Kuan Roza Kucharczyk Ashok Kumar Raj Kumar Sharad Kumar Mondira Kundu Hsing-Jien Kung Tino Kurz Ho Jeong Kwon Albert R La Spada Frank Lafont Trond Lamark Jacques Landry Jon D Lane Pierre Lapaquette Jocelyn F Laporte Lajos László Sergio Lavandero Josée N Lavoie Robert Layfield Pedro A Lazo Weidong Le Laurent Le Cam Daniel J Ledbetter Alvin J X Lee Byung-Wan Lee Gyun Min Lee Jongdae Lee Ju-Hyun Lee Michael Lee Myung-Shik Lee Sug Hyung Lee Christiaan Leeuwenburgh Patrick Legembre Renaud Legouis Michael Lehmann Huan-Yao Lei Qun-Ying Lei David A Leib José Leiro John J Lemasters Antoinette Lemoine Maciej S Lesniak Dina Lev Victor V Levenson Beth Levine Efrat Levy Faqiang Li Jun-Lin Li Lian Li Sheng Li Weijie Li Xue-Jun Li Yan-bo Li Yi-Ping Li Chengyu Liang Qiangrong Liang Yung-Feng Liao Pawel P Liberski Andrew Lieberman Hyunjung J Lim Kah-Leong Lim Kyu Lim Chiou-Feng Lin Fu-Cheng Lin Jian Lin Jiandie D Lin Kui Lin Wan-Wan Lin Weei-Chin Lin Yi-Ling Lin Rafael Linden Paul Lingor Jennifer Lippincott-Schwartz Michael P Lisanti Paloma B Liton Bo Liu Chun-Feng Liu Kaiyu Liu Leyuan Liu Qiong A Liu Wei Liu Young-Chau Liu Yule Liu Richard A Lockshin Chun-Nam Lok Sagar Lonial Benjamin Loos Gabriel Lopez-Berestein Carlos López-Otín Laura Lossi Michael T Lotze Peter Lőw Binfeng Lu Bingwei Lu Bo Lu Zhen Lu Frédéric Luciano Nicholas W Lukacs Anders H Lund Melinda A Lynch-Day Yong Ma Fernando Macian Jeff P MacKeigan Kay F Macleod Frank Madeo Luigi Maiuri Maria Chiara Maiuri Davide Malagoli May Christine V Malicdan Walter Malorni Na Man Eva-Maria Mandelkow Stéphen Manon Irena Manov Kai Mao Xiang Mao Zixu Mao Philippe Marambaud Daniela Marazziti Yves L Marcel Katie Marchbank Piero Marchetti Stefan J Marciniak Mateus Marcondes Mohsen Mardi Gabriella Marfe Guillermo Mariño Maria Markaki Mark R Marten Seamus J Martin Camille Martinand-Mari Wim Martinet Marta Martinez-Vicente Matilde Masini Paola Matarrese Saburo Matsuo Raffaele Matteoni Andreas Mayer Nathalie M Mazure David J McConkey Melanie J McConnell Catherine McDermott Christine McDonald Gerald M McInerney Sharon L McKenna BethAnn McLaughlin Pamela J McLean Christopher R McMaster G Angus McQuibban Alfred J Meijer Miriam H Meisler Alicia Meléndez Thomas J Melia Gerry Melino Maria A Mena Javier A Menendez Rubem F S Menna-Barreto Manoj B Menon Fiona M Menzies Carol A Mercer Adalberto Merighi Diane E Merry Stefania Meschini Christian G Meyer Thomas F Meyer Chao-Yu Miao Jun-Ying Miao Paul A M Michels Carine Michiels Dalibor Mijaljica Ana Milojkovic Saverio Minucci Clelia Miracco Cindy K Miranti Ioannis Mitroulis Keisuke Miyazawa Noboru Mizushima Baharia Mograbi Simin Mohseni Xavier Molero Bertrand Mollereau Faustino Mollinedo Takashi Momoi Iryna Monastyrska Martha M Monick Mervyn J Monteiro Michael N Moore Rodrigo Mora Kevin Moreau Paula I Moreira Yuji Moriyasu Jorge Moscat Serge Mostowy Jeremy C Mottram Tomasz Motyl Charbel E-H Moussa Sylke Müller Sylviane Muller Karl Münger Christian Münz Leon O Murphy Maureen E Murphy Antonio Musarò Indira Mysorekar Eiichiro Nagata Kazuhiro Nagata Aimable Nahimana Usha Nair Toshiyuki Nakagawa Kiichi Nakahira Hiroyasu Nakano Hitoshi Nakatogawa Meera Nanjundan Naweed I Naqvi Derek P Narendra Masashi Narita Miguel Navarro Steffan T Nawrocki Taras Y Nazarko Andriy Nemchenko Mihai G Netea Thomas P Neufeld Paul A Ney Ioannis P Nezis Huu Phuc Nguyen Daotai Nie Ichizo Nishino Corey Nislow Ralph A Nixon Takeshi Noda Angelika A Noegel Anna Nogalska Satoru Noguchi Lucia Notterpek Ivana Novak Tomoyoshi Nozaki Nobuyuki Nukina Thorsten Nürnberger Beat Nyfeler Keisuke Obara Terry D Oberley Salvatore Oddo Michinaga Ogawa Toya Ohashi Koji Okamoto Nancy L Oleinick F Javier Oliver Laura J Olsen Stefan Olsson Onya Opota Timothy F Osborne Gary K Ostrander Kinya Otsu Jing-hsiung James Ou Mireille Ouimet Michael Overholtzer Bulent Ozpolat Paolo Paganetti Ugo Pagnini Nicolas Pallet Glen E Palmer Camilla Palumbo Tianhong Pan Theocharis Panaretakis Udai Bhan Pandey Zuzana Papackova Issidora Papassideri Irmgard Paris Junsoo Park Ohkmae K Park Jan B Parys Katherine R Parzych Susann Patschan Cam Patterson Sophie Pattingre John M Pawelek Jianxin Peng David H Perlmutter Ida Perrotta George Perry Shazib Pervaiz Matthias Peter Godefridus J Peters Morten Petersen Goran Petrovski James M Phang Mauro Piacentini Philippe Pierre Valérie Pierrefite-Carle Gérard Pierron Ronit Pinkas-Kramarski Antonio Piras Natik Piri Leonidas C Platanias Stefanie Pöggeler Marc Poirot Angelo Poletti Christian Poüs Mercedes Pozuelo-Rubio Mette Prætorius-Ibba Anil Prasad Mark Prescott Muriel Priault Nathalie Produit-Zengaffinen Ann Progulske-Fox Tassula Proikas-Cezanne Serge Przedborski Karin Przyklenk Rosa Puertollano Julien Puyal Shu-Bing Qian Liang Qin Zheng-Hong Qin Susan E Quaggin Nina Raben Hannah Rabinowich Simon W Rabkin Irfan Rahman Abdelhaq Rami Georg Ramm Glenn Randall Felix Randow V Ashutosh Rao Jeffrey C Rathmell Brinda Ravikumar Swapan K Ray Bruce H Reed John C Reed Fulvio Reggiori Anne Régnier-Vigouroux Andreas S Reichert John J Reiners Russel J Reiter Jun Ren José L Revuelta Christopher J Rhodes Konstantinos Ritis Elizete Rizzo Jeffrey Robbins Michel Roberge Hernan Roca Maria C Roccheri Stephane Rocchi H Peter Rodemann Santiago Rodríguez de Córdoba Bärbel Rohrer Igor B Roninson Kirill Rosen Magdalena M Rost-Roszkowska Mustapha Rouis Kasper M A Rouschop Francesca Rovetta Brian P Rubin David C Rubinsztein Klaus Ruckdeschel Edmund B Rucker Assaf Rudich Emil Rudolf Nelson Ruiz-Opazo Rossella Russo Tor Erik Rusten Kevin M Ryan Stefan W Ryter David M Sabatini Junichi Sadoshima Tapas Saha Tatsuya Saitoh Hiroshi Sakagami Yasuyoshi Sakai Ghasem Hoseini Salekdeh Paolo Salomoni Paul M Salvaterra Guy Salvesen Rosa Salvioli Anthony M J Sanchez José A Sánchez-Alcázar Ricardo Sánchez-Prieto Marco Sandri Uma Sankar Poonam Sansanwal Laura Santambrogio Shweta Saran Sovan Sarkar Minnie Sarwal Chihiro Sasakawa Ausra Sasnauskiene Miklós Sass Ken Sato Miyuki Sato Anthony H V Schapira Michael Scharl Hermann M Schätzl Wiep Scheper Stefano Schiaffino Claudio Schneider Marion E Schneider Regine Schneider-Stock Patricia V Schoenlein Daniel F Schorderet Christoph Schüller Gary K Schwartz Luca Scorrano Linda Sealy Per O Seglen Juan Segura-Aguilar Iban Seiliez Oleksandr Seleverstov Christian Sell Jong Bok Seo Duska Separovic Vijayasaradhi Setaluri Takao Setoguchi Carmine Settembre John J Shacka Mala Shanmugam Irving M Shapiro Eitan Shaulian Reuben J Shaw James H Shelhamer Han-Ming Shen Wei-Chiang Shen Zu-Hang Sheng Yang Shi Kenichi Shibuya Yoshihiro Shidoji Jeng-Jer Shieh Chwen-Ming Shih Yohta Shimada Shigeomi Shimizu Takahiro Shintani Orian S Shirihai Gordon C Shore Andriy A Sibirny Stan B Sidhu Beata Sikorska Elaine C M Silva-Zacarin Alison Simmons Anna Katharina Simon Hans-Uwe Simon Cristiano Simone Anne Simonsen David A Sinclair Rajat Singh Debasish Sinha Frank A Sinicrope Agnieszka Sirko Parco M Siu Efthimios Sivridis Vojtech Skop Vladimir P Skulachev Ruth S Slack Soraya S Smaili Duncan R Smith Maria S Soengas Thierry Soldati Xueqin Song Anil K Sood Tuck Wah Soong Federica Sotgia Stephen A Spector Claudia D Spies Wolfdieter Springer Srinivasa M Srinivasula Leonidas Stefanis Joan S Steffan Ruediger Stendel Harald Stenmark Anastasis Stephanou Stephan T Stern Cinthya Sternberg Björn Stork Peter Strålfors Carlos S Subauste Xinbing Sui David Sulzer Jiaren Sun Shi-Yong Sun Zhi-Jun Sun Joseph J Y Sung Kuninori Suzuki Toshihiko Suzuki Michele S Swanson Charles Swanton Sean T Sweeney Lai-King Sy Gyorgy Szabadkai Ira Tabas Heinrich Taegtmeyer Marco Tafani Krisztina Takács-Vellai Yoshitaka Takano Kaoru Takegawa Genzou Takemura Fumihiko Takeshita Nicholas J Talbot Kevin S W Tan Keiji Tanaka Kozo Tanaka Daolin Tang Dingzhong Tang Isei Tanida Bakhos A Tannous Nektarios Tavernarakis Graham S Taylor Gregory A Taylor J Paul Taylor Lance S Terada Alexei Terman Gianluca Tettamanti Karin Thevissen Craig B Thompson Andrew Thorburn Michael Thumm FengFeng Tian Yuan Tian Glauco Tocchini-Valentini Aviva M Tolkovsky Yasuhiko Tomino Lars Tönges Sharon A Tooze Cathy Tournier John Tower Roberto Towns Vladimir Trajkovic Leonardo H Travassos Ting-Fen Tsai Mario P Tschan Takeshi Tsubata Allan Tsung Boris Turk Lorianne S Turner Suresh C Tyagi Yasuo Uchiyama Takashi Ueno Midori Umekawa Rika Umemiya-Shirafuji Vivek K Unni Maria I Vaccaro Enza Maria Valente Greet Van den Berghe Ida J van der Klei Wouter van Doorn Linda F van Dyk Marjolein van Egmond Leo A van Grunsven Peter Vandenabeele Wim P Vandenberghe Ilse Vanhorebeek Eva C Vaquero Guillermo Velasco Tibor Vellai Jose Miguel Vicencio Richard D Vierstra Miquel Vila Cécile Vindis Giampietro Viola Maria Teresa Viscomi Olga V Voitsekhovskaja Clarissa von Haefen Marcela Votruba Keiji Wada Richard Wade-Martins Cheryl L Walker Craig M Walsh Jochen Walter Xiang-Bo Wan Aimin Wang Chenguang Wang Dawei Wang Fan Wang Fen Wang Guanghui Wang Haichao Wang Hong-Gang Wang Horng-Dar Wang Jin Wang Ke Wang Mei Wang Richard C Wang Xinglong Wang Xuejun Wang Ying-Jan Wang Yipeng Wang Zhen Wang Zhigang Charles Wang Zhinong Wang Derick G Wansink Diane M Ward Hirotaka Watada Sarah L Waters Paul Webster Lixin Wei Conrad C Weihl William A Weiss Scott M Welford Long-Ping Wen Caroline A Whitehouse J Lindsay Whitton Alexander J Whitworth Tom Wileman John W Wiley Simon Wilkinson Dieter Willbold Roger L Williams Peter R Williamson Bradly G Wouters Chenghan Wu Dao-Cheng Wu William K K Wu Andreas Wyttenbach Ramnik J Xavier Zhijun Xi Pu Xia Gengfu Xiao Zhiping Xie Zhonglin Xie Da-zhi Xu Jianzhen Xu Liang Xu Xiaolei Xu Ai Yamamoto Akitsugu Yamamoto Shunhei Yamashina Michiaki Yamashita Xianghua Yan Mitsuhiro Yanagida Dun-Sheng Yang Elizabeth Yang Jin-Ming Yang Shi Yu Yang Wannian Yang Wei Yuan Yang Zhifen Yang Meng-Chao Yao Tso-Pang Yao Behzad Yeganeh Wei-Lien Yen Jia-jing Yin Xiao-Ming Yin Ook-Joon Yoo Gyesoon Yoon Seung-Yong Yoon Tomohiro Yorimitsu Yuko Yoshikawa Tamotsu Yoshimori Kohki Yoshimoto Ho Jin You Richard J Youle Anas Younes Li Yu Long Yu Seong-Woon Yu Wai Haung Yu Zhi-Min Yuan Zhenyu Yue Cheol-Heui Yun Michisuke Yuzaki Olga Zabirnyk Elaine Silva-Zacarin David Zacks Eldad Zacksenhaus Nadia Zaffaroni Zahra Zakeri Herbert J Zeh Scott O Zeitlin Hong Zhang Hui-Ling Zhang Jianhua Zhang Jing-Pu Zhang Lin Zhang Long Zhang Ming-Yong Zhang Xu Dong Zhang Mantong Zhao Yi-Fang Zhao Ying Zhao Zhizhuang J Zhao Xiaoxiang Zheng Boris Zhivotovsky Qing Zhong Cong-Zhao Zhou Changlian Zhu Wei-Guo Zhu Xiao-Feng Zhu Xiongwei Zhu Yuangang Zhu Teresa Zoladek Wei-Xing Zong Antonio Zorzano Jürgen Zschocke Brian Zuckerbraun

Autophagy 2012 Apr;8(4):445-544

Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA.

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http://dx.doi.org/10.4161/auto.19496DOI Listing
April 2012

Exosomal cell-to-cell transmission of alpha synuclein oligomers.

Mol Neurodegener 2012 Aug 24;7:42. Epub 2012 Aug 24.

MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Charlestown, MA, USA.

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August 2012

Molecular chaperones and co-chaperones in Parkinson disease.

Neuroscientist 2012 Dec 24;18(6):589-601. Epub 2012 Jul 24.

MassGeneral Institute for Neurodegenerative Disease, Charlestown, MA 02219, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3904222PMC
December 2012

Protein degradation pathways in Parkinson's disease: curse or blessing.

Acta Neuropathol 2012 Aug 29;124(2):153-72. Epub 2012 Jun 29.

Institute of Anatomy and Cell Biology, Ruprecht-Karls University Heidelberg, INF 307, 69120, Heidelberg, Germany.

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August 2012

Alpha-synuclein's degradation in vivo: opening a new (cranial) window on the roles of degradation pathways in Parkinson disease.

Autophagy 2012 Feb 1;8(2):281-3. Epub 2012 Feb 1.

MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.

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February 2012

Molecular chaperones in Parkinson's disease--present and future.

J Parkinsons Dis 2011 ;1(4):299-320

MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA.

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June 2014

SIRT1 protects against α-synuclein aggregation by activating molecular chaperones.

J Neurosci 2012 Jan;32(1):124-32

Paul F. Glenn Laboratory and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3263206PMC
January 2012

Distinct roles in vivo for the ubiquitin-proteasome system and the autophagy-lysosomal pathway in the degradation of α-synuclein.

J Neurosci 2011 Oct;31(41):14508-20

Mass General Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3587176PMC
October 2011

Drug targets from genetics: α-synuclein.

CNS Neurol Disord Drug Targets 2011 Sep;10(6):712-23

MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, 02129, USA.

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http://dx.doi.org/10.2174/187152711797247867DOI Listing
September 2011

Gaucher disease glucocerebrosidase and α-synuclein form a bidirectional pathogenic loop in synucleinopathies.

Cell 2011 Jul 23;146(1):37-52. Epub 2011 Jun 23.

Department of Neurology, Massachusetts General Hospital, Harvard Medical School, MassGeneral Institute for Neurodegenerative Disease, Charlestown, MA 02129, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3132082PMC
July 2011

Characterization of oligomer formation of amyloid-beta peptide using a split-luciferase complementation assay.

J Biol Chem 2011 Aug 7;286(31):27081-91. Epub 2011 Jun 7.

Department of Neurology, Alzheimer's Disease Research Unit, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3149301PMC
August 2011

Ubiquitinylation of α-synuclein by carboxyl terminus Hsp70-interacting protein (CHIP) is regulated by Bcl-2-associated athanogene 5 (BAG5).

PLoS One 2011 Feb 16;6(2):e14695. Epub 2011 Feb 16.

Department of Neurology, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, United States of America.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3040167PMC
February 2011

Studying protein degradation pathways in vivo using a cranial window-based approach.

Methods 2011 Mar 25;53(3):194-200. Epub 2010 Dec 25.

Alzheimer's Research Unit, MassGeneral Institute for Neurodegenerative Disease, MGH, Harvard Medical School, CNY114, 16th St., Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1016/j.ymeth.2010.12.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3057351PMC
March 2011

Heat-shock protein 70 modulates toxic extracellular α-synuclein oligomers and rescues trans-synaptic toxicity.

FASEB J 2011 Jan 27;25(1):326-36. Epub 2010 Sep 27.

Department of Neurology, Massachusetts General Hospital, Harvard Medical School, MassGeneral Institute for Neurodegenerative Disease, 114 16th St., Charlestown, MA 02129, USA.

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January 2011

In vivo imaging of alpha-synuclein in mouse cortex demonstrates stable expression and differential subcellular compartment mobility.

PLoS One 2010 May 11;5(5):e10589. Epub 2010 May 11.

Alzheimer's Research Unit, MassGeneral Institute for Neurodegenerative Disease, MGH Harvard Medical School, Charlestown, Massachusetts, United States of America.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2868057PMC
May 2010

Brain-permeable small-molecule inhibitors of Hsp90 prevent alpha-synuclein oligomer formation and rescue alpha-synuclein-induced toxicity.

J Pharmacol Exp Ther 2010 Mar 24;332(3):849-57. Epub 2009 Nov 24.

Department of Neurology, Massachusetts General Hospital, MassGeneral Institute for Neurodegenerative Disease, 114 16th Street, Charlestown, MA 02129, USA.

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March 2010

Converse modulation of toxic alpha-synuclein oligomers in living cells by N'-benzylidene-benzohydrazide derivates and ferric iron.

Biochem Biophys Res Commun 2010 Jan 13;391(1):461-6. Epub 2009 Nov 13.

Center for Neuropathology and Prion Research, Ludwig-Maximilians-University, Feodor-Lynen-Str 23, 81377 Munich, Germany.

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January 2010

Tyrosine and serine phosphorylation of alpha-synuclein have opposing effects on neurotoxicity and soluble oligomer formation.

J Clin Invest 2009 Nov 12;119(11):3257-65. Epub 2009 Oct 12.

Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1172/JCI39088DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2769182PMC
November 2009

Dopamine-induced conformational changes in alpha-synuclein.

PLoS One 2009 Sep 4;4(9):e6906. Epub 2009 Sep 4.

MassGeneral Institute for Neurodegenerative Disease, Alzheimer Research Unit, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2731858PMC
September 2009

Alpha-synuclein S129 phosphorylation mutants do not alter nigrostriatal toxicity in a rat model of Parkinson disease.

J Neuropathol Exp Neurol 2009 May;68(5):515-24

MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129-4404, USA.

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http://dx.doi.org/10.1097/NEN.0b013e3181a24b53DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2753269PMC
May 2009

Comparison of transduction efficiency of recombinant AAV serotypes 1, 2, 5, and 8 in the rat nigrostriatal system.

J Neurochem 2009 May 24;109(3):838-45. Epub 2009 Feb 24.

MassGeneral Institute for Neurodegenerative Disease (MIND), Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129-4404, USA.

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http://dx.doi.org/10.1111/j.1471-4159.2009.06010.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2698947PMC
May 2009

Targeted overexpression of human alpha-synuclein triggers microglial activation and an adaptive immune response in a mouse model of Parkinson disease.

J Neuropathol Exp Neurol 2008 Dec;67(12):1149-58

Center for Neurodegeneration and Experimental Therapeutics, The University of Alabama at Birmingham, Alabama 35294-0021, USA.

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http://dx.doi.org/10.1097/NEN.0b013e31818e5e99DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2753200PMC
December 2008

CHIP targets toxic alpha-Synuclein oligomers for degradation.

J Biol Chem 2008 Jun 24;283(26):17962-8. Epub 2008 Apr 24.

Department of Neurology, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1074/jbc.M802283200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2936239PMC
June 2008

Formation of toxic oligomeric alpha-synuclein species in living cells.

PLoS One 2008 Apr 2;3(4):e1867. Epub 2008 Apr 2.

Alzheimer's Research Unit, MassGeneral Institute for Neurodegenerative Disease, MGH Harvard Medical School, Charlestown, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0001867PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2270899PMC
April 2008

Transcriptional dysregulation in a transgenic model of Parkinson disease.

Neurobiol Dis 2008 Mar 28;29(3):515-28. Epub 2007 Nov 28.

Neurology Department, Center for Neurodegeneration and Experimental Therapeutics, University of Alabama at Birmingham, Birmingham, AL 35294, USA.

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http://dx.doi.org/10.1016/j.nbd.2007.11.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2707844PMC
March 2008

Dopaminergic neuron loss and up-regulation of chaperone protein mRNA induced by targeted over-expression of alpha-synuclein in mouse substantia nigra.

J Neurochem 2007 Mar 4;100(6):1449-57. Epub 2007 Jan 4.

Alzheimer's Disease Research Unit, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA.

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http://dx.doi.org/10.1111/j.1471-4159.2006.04310.xDOI Listing
March 2007

Small heat shock proteins protect against alpha-synuclein-induced toxicity and aggregation.

Biochem Biophys Res Commun 2006 Dec 26;351(3):631-8. Epub 2006 Oct 26.

Alzheimer's Research Unit, MassGeneral Institute for Neurodegenerative Disease, MGH, Harvard Medical School, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1016/j.bbrc.2006.10.085DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1934426PMC
December 2006

Detection of novel intracellular alpha-synuclein oligomeric species by fluorescence lifetime imaging.

FASEB J 2006 Oct;20(12):2050-7

MassGeneral Institute for Neurodegenerative Disease, Alzheimer's Disease Research Unit, Massachusetts General Hospital, 114 16 St., Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1096/fj.05-5422comDOI Listing
October 2006

Pharmacological promotion of inclusion formation: a therapeutic approach for Huntington's and Parkinson's diseases.

Proc Natl Acad Sci U S A 2006 Mar 6;103(11):4246-51. Epub 2006 Mar 6.

Center for Cancer Research, Massachusetts Institute of Technology, Room E18-505, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1073/pnas.0511256103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1449678PMC
March 2006

Caspase-3-derived C-terminal product of synphilin-1 displays antiapoptotic function via modulation of the p53-dependent cell death pathway.

J Biol Chem 2006 Apr 22;281(17):11515-22. Epub 2006 Feb 22.

Institut de Pharmacologie Moléculaire et Cellulaire, CNRS, UMR6097/Université de Nice Sophia Antipolis, Equipe Labellisée Fondation pour la Recherche Médicale, 660 Route des Lucioles, 06560, Valbonne, France.

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April 2006

Alpha-synuclein and chaperones in dementia with Lewy bodies.

J Neuropathol Exp Neurol 2005 Dec;64(12):1058-66

Massachusetts General Institute for Neurodegenerative Disease, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA.

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http://dx.doi.org/10.1097/01.jnen.0000190063.90440.69DOI Listing
December 2005

The co-chaperone carboxyl terminus of Hsp70-interacting protein (CHIP) mediates alpha-synuclein degradation decisions between proteasomal and lysosomal pathways.

J Biol Chem 2005 Jun 21;280(25):23727-34. Epub 2005 Apr 21.

Alzheimer Disease Research Unit, Department of Neurology, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M503326200
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June 2005

A single amino acid substitution differentiates Hsp70-dependent effects on alpha-synuclein degradation and toxicity.

Biochem Biophys Res Commun 2004 Dec;325(1):367-73

MassGeneral Institute for Neurodegenerative disease, Alzheimer Disease Research Unit, Massachusetts General Hospital, 114 16th Street, Charlestown, MA 02129, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S0006291X0402322
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http://dx.doi.org/10.1016/j.bbrc.2004.10.037DOI Listing
December 2004

Geldanamycin induces Hsp70 and prevents alpha-synuclein aggregation and toxicity in vitro.

Biochem Biophys Res Commun 2004 Aug;321(3):665-9

Department of Neurology, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, 114 16th Street, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1016/j.bbrc.2004.07.021DOI Listing
August 2004

Hsp70 Reduces alpha-Synuclein Aggregation and Toxicity.

J Biol Chem 2004 Jun 25;279(24):25497-502. Epub 2004 Mar 25.

Alzheimer's Disease Research Laboratory, Harvard Medical School, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA.

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http://dx.doi.org/10.1074/jbc.M400255200DOI Listing
June 2004

TorsinA and heat shock proteins act as molecular chaperones: suppression of alpha-synuclein aggregation.

J Neurochem 2002 Nov;83(4):846-54

Alzheimer's Disease Research Unit, Center for Aging, Genetics and Neurodegeneration, Massachusetts General Hospital East, Charlestown, Massachusetts 02129, USA.

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http://dx.doi.org/10.1046/j.1471-4159.2002.01190.xDOI Listing
November 2002

An alternatively spliced form of rodent alpha-synuclein forms intracellular inclusions in vitro: role of the carboxy-terminus in alpha-synuclein aggregation.

Neurosci Lett 2002 May;323(3):219-23

Alzheimer's Disease Research Unit, Center for Aging, Genetics and Neurodegeneration, Massachusetts General Hospital East, 114 16th Street, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1016/s0304-3940(02)00154-4DOI Listing
May 2002