Pamela J Lein

Pamela J Lein

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Pamela J Lein

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Sex-Dependent Effects of 2,2',3,5',6-Pentachlorobiphenyl on Dendritic Arborization of Primary Mouse Neurons.

Toxicol Sci 2019 Mar;168(1):95-109

Department of Molecular Biosciences, School of Veterinary Medicine, University of California Davis, Davis, California 95616.

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http://dx.doi.org/10.1093/toxsci/kfy277DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390665PMC
March 2019

Pretreatment with pyridostigmine bromide has no effect on seizure behavior or 24 hour survival in the rat model of acute diisopropylfluorophosphate intoxication.

Neurotoxicology 2019 Mar 7;73:81-84. Epub 2019 Mar 7.

Department of Molecular Biosciences, School of Veterinary Medicine, University of California-Davis, 1089 Veterinary Medicine Drive, Davis, CA, 95616, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuro.2019.03.001DOI Listing
March 2019

Increased severity of fragile X spectrum disorders in the agricultural community of Ricaurte, Colombia.

Int J Dev Neurosci 2019 Feb 29;72:1-5. Epub 2018 Oct 29.

Medical Investigation of Neurodevelopmental Disorders (MIND) Institute, University of California Davis, Sacramento, CA, USA; Department of Pediatrics, University of California Davis School of Medicine, Sacramento, CA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ijdevneu.2018.10.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354926PMC
February 2019

Effects of thyroid hormone disruption on the ontogenetic expression of thyroid hormone signaling genes in developing zebrafish (Danio rerio).

Gen Comp Endocrinol 2019 02 15;272:20-32. Epub 2018 Nov 15.

Department of Molecular Biosciences, University of California-Davis School of Veterinary Medicine, Davis, CA 95616, United States. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00166480183030
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http://dx.doi.org/10.1016/j.ygcen.2018.11.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331280PMC
February 2019

Genetic mutations in Ca signaling alter dendrite morphology and social approach in juvenile mice.

Genes Brain Behav 2019 01 6;18(1):e12526. Epub 2018 Nov 6.

Department of Molecular Biosciences, University of California-Davis, School of Veterinary Medicine, Davis, California.

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http://dx.doi.org/10.1111/gbb.12526DOI Listing
January 2019

Teratological and Behavioral Screening of the National Toxicology Program 91-Compound Library in Zebrafish (Danio rerio).

Toxicol Sci 2019 Jan;167(1):77-91

Department of Molecular Biosciences, School of Veterinary Medicine, University of California-Davis, Davis, CA California 95616.

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http://dx.doi.org/10.1093/toxsci/kfy266DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317431PMC
January 2019

Developmental exposure to silver nanoparticles at environmentally relevant concentrations alters swimming behavior in zebrafish (Danio rerio).

Environ Toxicol Chem 2018 12 8;37(12):3018-3024. Epub 2018 Nov 8.

Department of Molecular Biosciences, University of California-Davis School of Veterinary Medicine, Davis, California, USA.

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http://doi.wiley.com/10.1002/etc.4275
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http://dx.doi.org/10.1002/etc.4275DOI Listing
December 2018

3,3'-Dichlorobiphenyl (PCB 11) promotes dendritic arborization in primary rat cortical neurons via a CREB-dependent mechanism.

Arch Toxicol 2018 Nov 17;92(11):3337-3345. Epub 2018 Sep 17.

Department of Molecular Biosciences, School of Veterinary Medicine, University of California-Davis, 1089 Veterinary Medicine Drive, Davis, CA, 95616, USA.

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http://dx.doi.org/10.1007/s00204-018-2307-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6196112PMC
November 2018

Mechanisms of organophosphorus pesticide toxicity in the context of airway hyperreactivity and asthma.

Am J Physiol Lung Cell Mol Physiol 2018 Oct 28;315(4):L485-L501. Epub 2018 Jun 28.

Department of Molecular Biosciences, University of California , Davis, California.

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http://dx.doi.org/10.1152/ajplung.00211.2018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6230874PMC
October 2018

PCB 95 promotes dendritic growth in primary rat hippocampal neurons via mTOR-dependent mechanisms.

Arch Toxicol 2018 Oct 21;92(10):3163-3173. Epub 2018 Aug 21.

Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, 1089 Veterinary Medicine Drive, Davis, CA, 95616, USA.

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http://dx.doi.org/10.1007/s00204-018-2285-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6162988PMC
October 2018

Opportunities and challenges for using the zebrafish to study neuronal connectivity as an endpoint of developmental neurotoxicity.

Neurotoxicology 2018 07 25;67:102-111. Epub 2018 Apr 25.

Department of Molecular Biosciences, University of California, Davis, CA, 95616, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuro.2018.04.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6177215PMC
July 2018

Simultaneous quantification of T4, T3, rT3, 3,5-T2 and 3,3'-T2 in larval zebrafish (Danio rerio) as a model to study exposure to polychlorinated biphenyls.

Biomed Chromatogr 2018 Jun 29;32(6):e4185. Epub 2018 Jan 29.

Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, CA, USA.

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http://dx.doi.org/10.1002/bmc.4185DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5980666PMC
June 2018

A Microfluidic Platform to Study Astrocyte Adhesion on Nanoporous Gold Thin Films.

Nanomaterials (Basel) 2018 Jun 21;8(7). Epub 2018 Jun 21.

Department of Electrical and Computer Engineering, University of California-Davis, Davis, CA 95616, USA.

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http://dx.doi.org/10.3390/nano8070452DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6070884PMC
June 2018

A magnetic resonance imaging study of early brain injury in a rat model of acute DFP intoxication.

Neurotoxicology 2018 05 26;66:170-178. Epub 2017 Nov 26.

Biomedical Magnetic Resonance Laboratory, Mallinckrodt Institute of Radiology, School of Medicine,Washington University in St. Louis, St. Louis, MO, 63110, United States. Electronic address:

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http://dx.doi.org/10.1016/j.neuro.2017.11.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5940565PMC
May 2018

Fc gamma receptors are expressed in the developing rat brain and activate downstream signaling molecules upon cross-linking with immune complex.

J Neuroinflammation 2018 Jan 6;15(1). Epub 2018 Jan 6.

Department of Molecular Biosciences, School of Veterinary Medicine, University of California, 1089 Veterinary Medicine Drive, Davis, CA, 95616, USA.

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https://jneuroinflammation.biomedcentral.com/articles/10.118
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http://dx.doi.org/10.1186/s12974-017-1050-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5756609PMC
January 2018

Species and Sex Differences in the Morphogenic Response of Primary Rodent Neurons to 3,3'-Dichlorobiphenyl (PCB 11).

Toxics 2017 Dec 23;6(1). Epub 2017 Dec 23.

Department of Molecular Biosciences, University of California, Davis, CA 95616, USA.

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http://dx.doi.org/10.3390/toxics6010004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5874777PMC
December 2017

A multi-tiered, in vivo, quantitative assay suite for environmental disruptors of thyroid hormone signaling.

Aquat Toxicol 2017 Sep 21;190:1-10. Epub 2017 Jun 21.

Department of Neurobiology, Physiology, and Behavior, College of Biological Sciences, University of California, Davis 95616-8519, USA. Electronic address:

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http://dx.doi.org/10.1016/j.aquatox.2017.06.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5558850PMC
September 2017

In vivo and in vitro sex differences in the dendritic morphology of developing murine hippocampal and cortical neurons.

Sci Rep 2017 08 16;7(1):8486. Epub 2017 Aug 16.

Department of Molecular Biosciences, School of Veterinary Medicine, University of California Davis, Davis, CA, USA.

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http://www.nature.com/articles/s41598-017-08459-z
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http://dx.doi.org/10.1038/s41598-017-08459-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5559594PMC
August 2017

From the Cover: MagneticResonance Imaging Reveals Progressive Brain Injury in Rats Acutely Intoxicated With Diisopropylfluorophosphate.

Toxicol Sci 2017 06;157(2):342-353

Department of Molecular Biosciences, School of Veterinary Medicine, University of California-Davis, Davis, California, USA.

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http://dx.doi.org/10.1093/toxsci/kfx049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5458789PMC
June 2017

Dental Pulp Stem Cells Model Early Life and Imprinted DNA Methylation Patterns.

Stem Cells 2017 04 19;35(4):981-988. Epub 2017 Jan 19.

Medical Microbiology and Immunology, UC Davis, Davis, California, USA.

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http://dx.doi.org/10.1002/stem.2563DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5367950PMC
April 2017

Valid statistical approaches for analyzing sholl data: Mixed effects versus simple linear models.

J Neurosci Methods 2017 03 16;279:33-43. Epub 2017 Jan 16.

Department of Molecular Biosciences, University of California, Davis, CA, United States. Electronic address:

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http://dx.doi.org/10.1016/j.jneumeth.2017.01.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5346342PMC
March 2017

BDE-99 impairs differentiation of human and mouse NPCs into the oligodendroglial lineage by species-specific modes of action.

Sci Rep 2017 03 20;7:44861. Epub 2017 Mar 20.

IUF- Leibniz Research Institute for Environmental Medicine, Auf'm Hennekamp 50, 40225, Duesseldorf, Germany.

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http://dx.doi.org/10.1038/srep44861DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5357893PMC
March 2017

Nanostructure Introduces Artifacts in Quantitative Immunofluorescence by Influencing Fluorophore Intensity.

Sci Rep 2017 03 27;7(1):427. Epub 2017 Mar 27.

Department of Electrical & Computer Engineering, University of California - Davis, Davis, CA, 95616, USA.

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http://dx.doi.org/10.1038/s41598-017-00447-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5428417PMC
March 2017

Neurotoxicity in Preclinical Models of Occupational Exposure to Organophosphorus Compounds.

Front Neurosci 2016 18;10:590. Epub 2017 Jan 18.

Department of Psychiatry, University of Iowa Carver College of MedicineIowa City, IA, USA; Interdisciplinary Graduate Program in Human Toxicology, University of Iowa Carver College of MedicineIowa City, IA, USA; Department of Neurology, University of Iowa Carver College of MedicineIowa City, IA, USA; Department of Free Radical and Radiation Biology Program, University of Iowa Carver College of MedicineIowa City, IA, USA; Department of Radiation Oncology Holden Comprehensive Cancer Center, University of Iowa Carver College of MedicineIowa City, IA, USA; Department of Veteran Affairs, University of Iowa Carver College of MedicineIowa City, IA, USA; Weill Cornell Autism Research Program, Weill Cornell Medical CollegeNew York, NY, USA.

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http://dx.doi.org/10.3389/fnins.2016.00590DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5241311PMC
January 2017

Nanoporous Gold Biointerfaces: Modifying Nanostructure to Control Neural Cell Coverage and Enhance Electrophysiological Recording Performance.

Adv Funct Mater 2017 Jan 12;27(3). Epub 2016 Dec 12.

Department of Electrical and Computer Engineering, University of California, Davis, Davis, CA 95616, USA.

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http://dx.doi.org/10.1002/adfm.201604631DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5471629PMC
January 2017

BMP7-induced dendritic growth in sympathetic neurons requires p75(NTR) signaling.

Dev Neurobiol 2016 09 22;76(9):1003-13. Epub 2016 Jan 22.

Center for Research on Occupational and Environmental Toxicology, Oregon Health and Science University, Portland, Oregon, 97239.

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http://dx.doi.org/10.1002/dneu.22371DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905816PMC
September 2016

Mechanisms of Reduced Astrocyte Surface Coverage in Cortical Neuron-Glia Co-cultures on Nanoporous Gold Surfaces.

Cell Mol Bioeng 2016 Sep 31;9(3):433-442. Epub 2016 May 31.

Department of Electrical and Computer Engineering, University of California - Davis, Davis, California 95616, United States.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5079442PMC
http://dx.doi.org/10.1007/s12195-016-0449-4DOI Listing
September 2016

Using the Morris water maze to assess spatial learning and memory in weanling mice.

PLoS One 2015 17;10(4):e0124521. Epub 2015 Apr 17.

Department of Molecular Biosciences, School of Veterinary Medicine, University of California Davis, Davis, CA, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0124521PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4401674PMC
April 2016

Chasing the Elusive Benzofuran Impurity of the THR Antagonist NH-3: Synthesis, Isotope Labeling, and Biological Activity.

J Org Chem 2016 Mar 18;81(5):1870-6. Epub 2016 Feb 18.

Department of Pharmacology, University of California , Davis, California 95616, United States.

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http://dx.doi.org/10.1021/acs.joc.5b02665DOI Listing
March 2016

DNA methylation: a mechanism linking environmental chemical exposures to risk of autism spectrum disorders?

Environ Epigenet 2016 Mar 30;2(1). Epub 2016 Jan 30.

Department of Molecular Biosciences, School of Veterinary Medicine, University of California Davis, Davis, CA, USA.

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http://dx.doi.org/10.1093/eep/dvv012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4856164PMC
March 2016

Repeated exposure to neurotoxic levels of chlorpyrifos alters hippocampal expression of neurotrophins and neuropeptides.

Toxicology 2016 Jan 13;340:53-62. Epub 2016 Jan 13.

United States Army Center for Environmental Health Research (USACEHR), Frederick, MD 21702-5010, United States. Electronic address:

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http://dx.doi.org/10.1016/j.tox.2016.01.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4777610PMC
January 2016

Subacute nicotine co-exposure has no effect on 2,2',3,5',6- pentachlorobiphenyl disposition but alters hepatic cytochrome P450 expression in the male rat.

Toxicology 2015 Dec 14;338:59-68. Epub 2015 Oct 14.

Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, California, USA.

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http://dx.doi.org/10.1016/j.tox.2015.10.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4658283PMC
December 2015

The influence of sensitization on mechanisms of organophosphorus pesticide-induced airway hyperreactivity.

Am J Respir Cell Mol Biol 2015 Nov;53(5):738-47

1 Pulmonary and Critical Care Medicine, Oregon Health and Science University, Portland, Oregon; and.

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http://dx.doi.org/10.1165/rcmb.2014-0444OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4742952PMC
November 2015

Behavioral assessment of NIH Swiss mice acutely intoxicated with tetramethylenedisulfotetramine.

Neurotoxicol Teratol 2015 Jan-Feb;47:36-45. Epub 2014 Nov 8.

Department of Molecular Biosciences, School of Veterinary Medicine, University of California Davis, Davis, CA, USA; MIND Institute, School of Medicine, University of California Davis, Sacramento, CA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ntt.2014.10.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4291292PMC
September 2015

Effect of pregnancy on the disposition of 2,2',3,5',6-pentachlorobiphenyl (PCB 95) atropisomers and their hydroxylated metabolites in female mice.

Chem Res Toxicol 2015 Sep 13;28(9):1774-83. Epub 2015 Aug 13.

Department of Occupational and Environmental Health, College of Public Health, The University of Iowa , Iowa City, Iowa 52242-5000, United States.

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http://dx.doi.org/10.1021/acs.chemrestox.5b00241DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4579038PMC
September 2015

Reactive oxygen species are involved in BMP-induced dendritic growth in cultured rat sympathetic neurons.

Mol Cell Neurosci 2015 Jul 14;67:116-25. Epub 2015 Jun 14.

Department of Molecular Biosciences, University of California, Davis, CA, USA.

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http://dx.doi.org/10.1016/j.mcn.2015.06.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4550485PMC
July 2015

Rapid throughput analysis demonstrates that chemicals with distinct seizurogenic mechanisms differentially alter Ca2+ dynamics in networks formed by hippocampal neurons in culture.

Mol Pharmacol 2015 Apr 12;87(4):595-605. Epub 2015 Jan 12.

State Key Laboratory of Natural Medicines and Jiangsu Provincial Key laboratory for TCM Evaluation and Translational Development, China Pharmaceutical University, Nanjing, P.R. China (Z.C., X.Z., Y.C.); Department of Molecular Biosciences, School of Veterinary Medicine (Z.C., Y.C., S.H., P.J.L., I.N.P.) and Department of Pharmacology, School of Medicine (H.W.),University of California, Davis, California

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http://dx.doi.org/10.1124/mol.114.096701DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4366799PMC
April 2015

Nanoporous gold as a neural interface coating: effects of topography, surface chemistry, and feature size.

ACS Appl Mater Interfaces 2015 Apr 2;7(13):7093-100. Epub 2015 Mar 2.

§Lawrence Livermore National Laboratory, Livermore, California 94551, United States.

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http://dx.doi.org/10.1021/acsami.5b00410DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4517587PMC
April 2015

Longitudinal assessment of occupational exposures to the organophosphorous insecticides chlorpyrifos and profenofos in Egyptian cotton field workers.

Int J Hyg Environ Health 2015 Mar 7;218(2):203-11. Epub 2014 Nov 7.

Department of Pharmacology & Toxicology, State University of New York at Buffalo, Buffalo, NY, USA; Department of Epidemiology and Environmental Health, State University of New York at Buffalo, Buffalo, NY, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ijheh.2014.10.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4323691PMC
March 2015

A novel carboline derivative inhibits nitric oxide formation in macrophages independent of effects on tumor necrosis factor α and interleukin-1β expression.

J Pharmacol Exp Ther 2015 Mar 23;352(3):438-47. Epub 2014 Dec 23.

Department of Molecular Biosciences, School of Veterinary Medicine (A.C.G.G., F.G., P.J.L.), and Department of Neurology, School of Medicine (N.P., F.G.), University of California, Davis, California; and Department of Chemistry, University of Louisville, Louisville, Kentucky (B.P., M.H.N.).

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http://dx.doi.org/10.1124/jpet.114.220186DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4352593PMC
March 2015

Hepatic metabolism affects the atropselective disposition of 2,2',3,3',6,6'-hexachlorobiphenyl (PCB 136) in mice.

Environ Sci Technol 2015 Jan 10;49(1):616-25. Epub 2014 Dec 10.

Department of Occupational and Environmental Health, College of Public Health, The University of Iowa , Iowa City, Iowa 52242, United States.

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http://dx.doi.org/10.1021/es504766pDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4291784PMC
January 2015

Factors influencing adverse skin responses in rats receiving repeated subcutaneous injections and potential impact on neurobehavior.

Curr Neurobiol 2014 Dec;5(1-2):1-10

Department of Molecular Biosciences, School of Veterinary Medicine, University of California-Davis, Davis, CA, 95616, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4334164PMC
December 2014

Characterization of α-cypermethrin exposure in Egyptian agricultural workers.

Int J Hyg Environ Health 2014 Apr-May;217(4-5):538-45. Epub 2013 Nov 4.

Department of Pharmacology & Toxicology, State University of New York at Buffalo, Buffalo, NY, USA; Department of Social and Preventative Medicine, State University of New York at Buffalo, Buffalo, NY, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ijheh.2013.10.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3972299PMC
November 2014

Microcystins alter chemotactic behavior in Caenorhabditis elegans by selectively targeting the AWA sensory neuron.

Toxins (Basel) 2014 Jun 10;6(6):1813-36. Epub 2014 Jun 10.

Department of Molecular Biosciences, School of Veterinary Medicine, 1089 Veterinary Medicine Drive, 2225 VM3B, University of California, Davis, Davis, CA 95616, USA.

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http://dx.doi.org/10.3390/toxins6061813DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4073131PMC
June 2014

Cytochrome p450 mRNA expression in the rodent brain: species-, sex-, and region-dependent differences.

Drug Metab Dispos 2014 Feb 19;42(2):239-44. Epub 2013 Nov 19.

Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, California (M.S., P.J.L.) and Department of Occupational and Environmental Health, College of Public Health, The University of Iowa, Iowa City, Iowa (X.W., I.K.-K., H.-J.L.).

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http://dx.doi.org/10.1124/dmd.113.054239DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3912540PMC
February 2014

The environmental neurotoxicant PCB 95 promotes synaptogenesis via ryanodine receptor-dependent miR132 upregulation.

J Neurosci 2014 Jan;34(3):717-25

Integrative Physiology and Neuroscience, Washington State University, Pullman, Washington 99164, Department of Molecular Biosciences, University of California, Davis, California 95616, and Oregon Stem Cell Center, Oregon Health and Science University, Portland, Oregon 97239.

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http://dx.doi.org/10.1523/JNEUROSCI.2884-13.2014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3891953PMC
January 2014

Metabolism of 2,2',3,3',6,6'-hexachlorobiphenyl (PCB 136) atropisomers in tissue slices from phenobarbital or dexamethasone-induced rats is sex-dependent.

Xenobiotica 2013 Nov 12;43(11):933-47. Epub 2013 Apr 12.

Department of Occupational and Environmental Health, College of Public Health, The University of Iowa , Iowa City, IA , USA .

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http://dx.doi.org/10.3109/00498254.2013.785626DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3878182PMC
November 2013

Neuronal connectivity as a convergent target of gene × environment interactions that confer risk for Autism Spectrum Disorders.

Neurotoxicol Teratol 2013 Mar-Apr;36:3-16. Epub 2012 Dec 23.

Department of Molecular Biosciences, University of California at Davis School of Veterinary Medicine, Davis, CA 95616, United States.

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http://dx.doi.org/10.1016/j.ntt.2012.12.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3610799PMC
September 2013

Oxygen tension modulates differentiation and primary macrophage functions in the human monocytic THP-1 cell line.

PLoS One 2013 23;8(1):e54926. Epub 2013 Jan 23.

Department of Molecular Biosciences, School of Veterinary Medicine, University of California Davis, Davis, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0054926PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3552948PMC
June 2013

Macrophage TNF-α mediates parathion-induced airway hyperreactivity in guinea pigs.

Am J Physiol Lung Cell Mol Physiol 2013 Apr 1;304(8):L519-29. Epub 2013 Feb 1.

Division of Pulmonary and Critical Care Medicine, Oregon Health and Science University, Portland, OR 97239, USA.

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http://dx.doi.org/10.1152/ajplung.00381.2012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3625991PMC
April 2013

Advancing the science of developmental neurotoxicity (DNT): testing for better safety evaluation.

ALTEX 2012 ;29(2):202-15

Validation of Alternative Methods Unit, Institute for Health and Consumer Protection, European Commission Joint Research Centre, Ispra (VA), Italy.

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http://dx.doi.org/10.14573/altex.2012.2.202DOI Listing
January 2013

PON1 status does not influence cholinesterase activity in Egyptian agricultural workers exposed to chlorpyrifos.

Toxicol Appl Pharmacol 2012 Dec 10;265(3):308-15. Epub 2012 Sep 10.

Department of Pharmacology and Toxicology, School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, NY 14214, USA.

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http://dx.doi.org/10.1016/j.taap.2012.08.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3513664PMC
December 2012

2,2',3,5',6-Pentachlorobiphenyl (PCB 95) and its hydroxylated metabolites are enantiomerically enriched in female mice.

Environ Sci Technol 2012 Oct 28;46(20):11393-401. Epub 2012 Sep 28.

Department of Occupational and Environmental Health, College of Public Health, The University of Iowa, Iowa City, Iowa, USA.

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http://dx.doi.org/10.1021/es302810tDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3475189PMC
October 2012

Translating neurobehavioural endpoints of developmental neurotoxicity tests into in vitro assays and readouts.

Neurotoxicology 2012 Aug 12;33(4):911-24. Epub 2011 Oct 12.

Neurobehavioural Toxicology and Chemosensation, IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund, Germany.

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http://dx.doi.org/10.1016/j.neuro.2011.10.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3288589PMC
August 2012

PCB-95 promotes dendritic growth via ryanodine receptor-dependent mechanisms.

Environ Health Perspect 2012 Jul 25;120(7):997-1002. Epub 2012 Apr 25.

Program in Neuroscience, Department of Veterinary and Comparative Anatomy, Pharmacology and Physiology, Washington State University, Pullman, Washington, USA.

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http://dx.doi.org/10.1289/ehp.1104832DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3404670PMC
July 2012

PCB-95 modulates the calcium-dependent signaling pathway responsible for activity-dependent dendritic growth.

Environ Health Perspect 2012 Jul 25;120(7):1003-9. Epub 2012 Apr 25.

Program in Neuroscience, Department of Veterinary and Comparative Anatomy, Pharmacology and Physiology, Washington State University, Pullman, Washington, USA.

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http://dx.doi.org/10.1289/ehp.1104833DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3404671PMC
July 2012

Neuregulin-1 is neuroprotective in a rat model of organophosphate-induced delayed neuronal injury.

Toxicol Appl Pharmacol 2012 Jul 11;262(2):194-204. Epub 2012 May 11.

Department of Neurobiology, Neuroscience Institute, Morehouse School of Medicine, Atlanta, GA 30310, USA.

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http://dx.doi.org/10.1016/j.taap.2012.05.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3607352PMC
July 2012

Spatiotemporal patterns of GFAP upregulation in rat brain following acute intoxication with diisopropylfluorophosphate (DFP).

Curr Neurobiol 2012 Jul;3(2):90-97

Department of Neurobiology, Neuroscience Institute, Morehouse School of Medicine, Atlanta, GA, 30310, USA ; Institute of Infectious Disease, Xiangya Hospital, Central-South University, Changsha, China.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3772776PMC
July 2012

A review of experimental evidence linking neurotoxic organophosphorus compounds and inflammation.

Neurotoxicology 2012 Jun 10;33(3):575-84. Epub 2012 Feb 10.

Department of Molecular Biosciences, UC Davis School of Veterinary Medicine, One Shields Ave., Davis, CA 95616, USA.

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http://dx.doi.org/10.1016/j.neuro.2012.02.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3358519PMC
June 2012

Emerging concepts in neurotoxicology: models, mechanisms and modifying factors.

Authors:
Pamela J Lein

Neurotoxicology 2012 Jun 12;33(3):516-7. Epub 2012 Apr 12.

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June 2012

Allele and genotype frequencies of CYP2B6 and CYP2C19 polymorphisms in Egyptian agricultural workers.

J Toxicol Environ Health A 2012 ;75(4):232-41

Department of Pharmacology and Toxicology, School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, New York 14214, USA.

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http://www.tandfonline.com/doi/abs/10.1080/15287394.2012.641
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http://dx.doi.org/10.1080/15287394.2012.641201DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3500531PMC
April 2012

Inducing dendritic growth in cultured sympathetic neurons.

J Vis Exp 2012 Mar 21(61). Epub 2012 Mar 21.

Department of Molecular Biosciences, University of California, Davis, CA, USA.

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http://dx.doi.org/10.3791/3546DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3460579PMC
March 2012

Transcriptional responses of cultured rat sympathetic neurons during BMP-7-induced dendritic growth.

PLoS One 2011 13;6(7):e21754. Epub 2011 Jul 13.

Gene Microarray Shared Resource, Oregon Health & Science University, Portland, Oregon, United States of America.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3135585PMC
November 2011

Acute hippocampal slice preparation and hippocampal slice cultures.

Methods Mol Biol 2011 ;758:115-34

Department of Molecular Biosciences, School of Veterinary Medicine and Center for Children's Environmental Health, University of California, Davis, CA, USA.

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http://dx.doi.org/10.1007/978-1-61779-170-3_8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3499947PMC
November 2011

Pharmacokinetics and pharmacodynamics of chlorpyrifos in adult male Long-Evans rats following repeated subcutaneous exposure to chlorpyrifos.

Toxicology 2011 Sep 17;287(1-3):137-44. Epub 2011 Jun 17.

Department of Pharmacology and Toxicology, State University of New York at Buffalo, Buffalo, NY 14214, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S0300483X1100236
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http://dx.doi.org/10.1016/j.tox.2011.06.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3176336PMC
September 2011

Biomarkers of chlorpyrifos exposure and effect in Egyptian cotton field workers.

Environ Health Perspect 2011 Jun 11;119(6):801-6. Epub 2011 Jan 11.

Department of Community Medicine and Public Health, Faculty of Medicine, Menoufia University, Shebin El-Kom, Egypt.

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http://dx.doi.org/10.1289/ehp.1002873DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3114814PMC
June 2011

Developmental neurotoxicity testing: recommendations for developing alternative methods for the screening and prioritization of chemicals.

ALTEX 2011 ;28(1):9-15

National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, Research triangle Park, NC 27711, USA.

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June 2011

Spatiotemporal pattern of neuronal injury induced by DFP in rats: a model for delayed neuronal cell death following acute OP intoxication.

Toxicol Appl Pharmacol 2011 Jun 12;253(3):261-9. Epub 2011 Apr 12.

Department of Neurobiology, Neuroscience Institute, Morehouse School of Medicine, Atlanta, GA 30310, USA.

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http://dx.doi.org/10.1016/j.taap.2011.03.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3108263PMC
June 2011

Epoxyeicosatrienoic acids enhance axonal growth in primary sensory and cortical neuronal cell cultures.

J Neurochem 2011 May 24;117(4):632-42. Epub 2011 Jan 24.

Department of Neurological Surgery, Oregon Health & Science University, Portland, Oregon, USA.

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http://dx.doi.org/10.1111/j.1471-4159.2010.07139.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3081369PMC
May 2011

Chlorpyrifos-oxon disrupts zebrafish axonal growth and motor behavior.

Toxicol Sci 2011 May 23;121(1):146-59. Epub 2011 Feb 23.

Department of Molecular Biosciences, University of California Davis School of Veterinary Medicine, Davis, California 95616, USA.

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http://dx.doi.org/10.1093/toxsci/kfr028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3080187PMC
May 2011

Para- and ortho-substitutions are key determinants of polybrominated diphenyl ether activity toward ryanodine receptors and neurotoxicity.

Environ Health Perspect 2011 Apr 24;119(4):519-26. Epub 2010 Nov 24.

Department of Molecular Biosciences, School of Veterinary Medicine, University of California-Davis, Davis, California 95616, USA.

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https://ehp.niehs.nih.gov/doi/10.1289/ehp.1002728
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http://dx.doi.org/10.1289/ehp.1002728DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3080935PMC
April 2011

IFNγ Increases M2 Muscarinic Receptor Expression in Cultured Sympathetic Neurons.

Curr Neurobiol 2011 Apr;2(1):23-29

Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, CA, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3515643PMC
April 2011

Correlating neurobehavioral performance with biomarkers of organophosphorous pesticide exposure.

Neurotoxicology 2011 Mar 21;32(2):268-76. Epub 2010 Dec 21.

Center for Research on Occupational and Environmental Toxicology, Oregon Health & Science University, Portland, OR 97239, USA.

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http://dx.doi.org/10.1016/j.neuro.2010.12.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3057226PMC
March 2011