Pak-Chung Sham

Pak-Chung Sham

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Pak-Chung Sham

Publications by authors named "Pak-Chung Sham"

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QTLbase: an integrative resource for quantitative trait loci across multiple human molecular phenotypes.

Nucleic Acids Res 2019 Oct 10. Epub 2019 Oct 10.

Department of Pharmacology, Tianjin Key Laboratory of Inflammation Biology, 2011 Collaborative Innovation Center of Tianjin for Medical Epigenetics, School of Basic Medical Sciences, National Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin Medical University, Tianjin 300070, China.

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http://dx.doi.org/10.1093/nar/gkz888DOI Listing
October 2019

Single-cell transcriptomics reveals the landscape of intra-tumoral heterogeneity and stemness-related subpopulations in liver cancer.

Cancer Lett 2019 Sep 10;459:176-185. Epub 2019 Jun 10.

Department of Pathology, The University of Hong Kong, Hong Kong; State Key Laboratory of Liver Research, The University of Hong Kong, Hong Kong. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2019.06.002DOI Listing
September 2019

regBase: whole genome base-wise aggregation and functional prediction for human non-coding regulatory variants.

Nucleic Acids Res 2019 Sep 12. Epub 2019 Sep 12.

Department of Pharmacology, School of Basic Medical Sciences, Tianjin Key Laboratory of Inflammation Biology, National Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin Medical University, Tianjin, China.

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http://dx.doi.org/10.1093/nar/gkz774DOI Listing
September 2019

LINE1 and methylation of the adult striatum and prefrontal cortex exposed to prenatal immune activation.

Data Brief 2019 Aug 23;25:104003. Epub 2019 May 23.

Department of Psychiatry, The University of Hong Kong, Pokfulam, Hong Kong S.A.R., China.

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http://dx.doi.org/10.1016/j.dib.2019.104003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6545381PMC
August 2019

Positive effects of low LDL-C and statins on bone mineral density: an integrated epidemiological observation analysis and Mendelian randomization study.

Int J Epidemiol 2019 Jul 13. Epub 2019 Jul 13.

Centre for Genomic Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong.

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http://dx.doi.org/10.1093/ije/dyz145DOI Listing
July 2019

Exploring shared genetic bases and causal relationships of schizophrenia and bipolar disorder with 28 cardiovascular and metabolic traits.

Psychol Med 2019 Jun 26;49(8):1286-1298. Epub 2018 Jul 26.

Department of Psychiatry,University of Hong Kong,Pokfulam,Hong Kong.

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http://dx.doi.org/10.1017/S0033291718001812DOI Listing
June 2019

Commonality in dysregulated expression of gene sets in cortical brains of individuals with autism, schizophrenia, and bipolar disorder.

Transl Psychiatry 2019 05 24;9(1):152. Epub 2019 May 24.

Department of Psychiatry, The University of Hong Kong, Hong Kong, China.

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http://dx.doi.org/10.1038/s41398-019-0488-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6534650PMC
May 2019

Chemotherapy-Induced Cognitive Impairment Is Associated with Cytokine Dysregulation and Disruptions in Neuroplasticity.

Mol Neurobiol 2019 Mar 14;56(3):2234-2243. Epub 2018 Jul 14.

School of Chinese Medicine, LKS Faculty of Medicine, The University of Hong Kong, 10 Sassoon Road, Pokfulam, Hong Kong, China.

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http://dx.doi.org/10.1007/s12035-018-1224-4DOI Listing
March 2019

A powerful conditional gene-based association approach implicated functionally important genes for schizophrenia.

Bioinformatics 2019 Feb;35(4):628-635

The Centre for Genomic Sciences, The University of Hong Kong, Pokfulam, Hong Kong, China.

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http://dx.doi.org/10.1093/bioinformatics/bty682DOI Listing
February 2019

A joint study of whole exome sequencing and structural MRI analysis in major depressive disorder.

Psychol Med 2019 Feb 6:1-12. Epub 2019 Feb 6.

Psychiatric Laboratory and Mental Health Center, The State Key Laboratory of Biotherapy,West China Hospital of Sichuan University,Chengdu, Sichuan,China.

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http://dx.doi.org/10.1017/S0033291719000072DOI Listing
February 2019

Leveraging genome-wide association and clinical data in revealing schizophrenia subgroups.

J Psychiatr Res 2018 11 22;106:106-117. Epub 2018 Sep 22.

School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong; KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research of Common Diseases, Kunming Zoology Institute of Zoology and the Chinese University of Hong Kong, China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00223956183041
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http://dx.doi.org/10.1016/j.jpsychires.2018.09.010DOI Listing
November 2018

Age-Biomarkers-Clinical Risk Factors for Prediction of Cardiovascular Events in Patients With Coronary Artery Disease.

Arterioscler Thromb Vasc Biol 2018 10;38(10):2519-2527

From the Department of Medicine (Y.-K.W., C.Y.Y.C., K.-W.A., J.S.H.H., C.-H.L., K.-K.L., B.M.Y.C., A.X., K.S.L.L., H.-F.T.), the University of Hong Kong, China.

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https://www.ahajournals.org/doi/10.1161/ATVBAHA.118.311726
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http://dx.doi.org/10.1161/ATVBAHA.118.311726DOI Listing
October 2018

A powerful approach reveals numerous expression quantitative trait haplotypes in multiple tissues.

Bioinformatics 2018 09;34(18):3145-3150

Department of Psychiatry, The Centre for Genomic Sciences, State Key Laboratory of Brain and Cognitive Sciences, The University of Hong Kong, Pokfulam, Hong Kong, China.

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http://dx.doi.org/10.1093/bioinformatics/bty318DOI Listing
September 2018

GWAS4D: multidimensional analysis of context-specific regulatory variant for human complex diseases and traits.

Nucleic Acids Res 2018 07;46(W1):W114-W120

Department of Pharmacology, Collaborative Innovation Center of Tianjin for Medical Epigenetics, Tianjin Key Laboratory of Medical Epigenetics, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China.

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https://academic.oup.com/nar/article/46/W1/W114/4996581
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http://dx.doi.org/10.1093/nar/gky407DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6030885PMC
July 2018

Gabrb2-knockout mice displayed schizophrenia-like and comorbid phenotypes with interneuron-astrocyte-microglia dysregulation.

Transl Psychiatry 2018 07 17;8(1):128. Epub 2018 Jul 17.

Division of Life Science, Applied Genomics Center and State Key Laboratory of Molecular Neuroscience, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, People's Republic of China.

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http://dx.doi.org/10.1038/s41398-018-0176-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6048160PMC
July 2018

Rare variants and de novo variants in mesial temporal lobe epilepsy with hippocampal sclerosis.

Neurol Genet 2018 Jun 11;4(3):e245. Epub 2018 Jun 11.

Centre for Genomic Sciences and Department of Psychiatry (J.K.L.W., H.G., L.B., P.C.S., S.S.C.), Li Ka Shing Faculty of Medicine, The University of Hong Kong; Department of Medicine and Therapeutics (M.K., P.K.), The Chinese University of Hong Kong; Department of Medicine (P.W.N.), United Christian Hospital; Department of Medicine (C.H.T.L.), Queen Elizabeth Hospital, Hong Kong, China; Departments of Medicine and Neurology (P.K.), The University of Melbourne, Royal Melbourne Hospital, Australia; Department of Epidemiology and Preventive Medicine (S.S.C.) and Department of Anatomy and Anthropology (S.S.C.), Sackler Faculty of Medicine, Tel Aviv University, Israel; and The State Key Laboratory of Brain and Cognitive Sciences (P.C.S., S.S.C.).

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http://dx.doi.org/10.1212/NXG.0000000000000245DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5999346PMC
June 2018

Linnorm: improved statistical analysis for single cell RNA-seq expression data.

Nucleic Acids Res 2017 Dec;45(22):e179

Department of Health Sciences Research and Center for Individualized Medicine, Mayo Clinic, Scottsdale, AZ 85259, USA.

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http://dx.doi.org/10.1093/nar/gkx828DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5727406PMC
December 2017

Corrigendum: Linnorm: improved statistical analysis for single cell RNA-seq expression data.

Nucleic Acids Res 2017 12;45(22):13097

Department of Health Sciences Research and Center for Individualized Medicine, Mayo Clinic, Scottsdale, AZ 85259, USA.

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http://dx.doi.org/10.1093/nar/gkx1189DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5728397PMC
December 2017

Genetically deprived vitamin D exposure predisposes to atrial fibrillation.

Europace 2017 Dec;19(suppl_4):iv25-iv31

Division of Cardiology, Queen Mary Hospital, The University of Hong Kong, Hong Kong SAR, China.

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http://dx.doi.org/10.1093/europace/eux312DOI Listing
December 2017

Burden of rare variants in ALS genes influences survival in familial and sporadic ALS.

Neurobiol Aging 2017 10 20;58:238.e9-238.e15. Epub 2017 Jun 20.

Division of Neurology, Department of Medicine, University of Hong Kong, Hong Kong, P.R. China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01974580173020
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http://dx.doi.org/10.1016/j.neurobiolaging.2017.06.007DOI Listing
October 2017

Analysis of genome-wide association data highlights candidates for drug repositioning in psychiatry.

Nat Neurosci 2017 Oct 14;20(10):1342-1349. Epub 2017 Aug 14.

Department of Psychiatry, University of Hong Kong, Pokfulam, Hong Kong, China.

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http://dx.doi.org/10.1038/nn.4618DOI Listing
October 2017

The role of gene variants in the pathogenesis of neurodegenerative disorders as revealed by next generation sequencing studies: a review.

Transl Neurodegener 2017 6;6:27. Epub 2017 Oct 6.

Division of Neurology, Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong, People's Republic of China.

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http://dx.doi.org/10.1186/s40035-017-0098-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5639582PMC
October 2017

Polygenic scores via penalized regression on summary statistics.

Genet Epidemiol 2017 09 8;41(6):469-480. Epub 2017 May 8.

Centre for Genomic Sciences, University of Hong Kong, Hong Kong.

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http://dx.doi.org/10.1002/gepi.22050DOI Listing
September 2017

Exploring genetic associations with ceRNA regulation in the human genome.

Nucleic Acids Res 2017 Jun;45(10):5653-5665

Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute and Harvard T.H.Chan School of Public Health, Boston, MA 02215, USA.

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http://dx.doi.org/10.1093/nar/gkx331DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5449616PMC
June 2017

Patient complexity and genotype-phenotype correlations in biliary atresia: a cross-sectional analysis.

BMC Med Genomics 2017 04 17;10(1):22. Epub 2017 Apr 17.

Department of Surgery, 1/F Hong Kong Jockey Club Building for Interdisciplinary Research, 5 Sassoon Road, Pokfulam, Hong Kong.

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http://dx.doi.org/10.1186/s12920-017-0259-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5392958PMC
April 2017

A fast and powerful W-test for pairwise epistasis testing.

Nucleic Acids Res 2016 12 26;44(21):10526. Epub 2016 Sep 26.

Division of Biostatistics and Centre for Clinical Research and Biostatistics, JC School of Public Health and Primary Care, the Chinese University of Hong Kong, Shatin, N.T., Hong Kong SAR, China.

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http://dx.doi.org/10.1093/nar/gkw866DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5137446PMC
December 2016

A single low dose of valproic acid in late prenatal life alters postnatal behavior and glutamic acid decarboxylase levels in the mouse.

Behav Brain Res 2016 11 4;314:190-8. Epub 2016 Aug 4.

Department of Forensic and Neurodevelopmental Science, The Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK.

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http://dx.doi.org/10.1016/j.bbr.2016.08.006DOI Listing
November 2016

Inheritance-mode specific pathogenicity prioritization (ISPP) for human protein coding genes.

Bioinformatics 2016 10 26;32(20):3065-3071. Epub 2016 Jun 26.

Department of Psychiatry Centre for Genomics Science, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong.

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http://dx.doi.org/10.1093/bioinformatics/btw381DOI Listing
October 2016

Impact of Genetic Loci Identified in Genome-Wide Association Studies on Diabetic Retinopathy in Chinese Patients With Type 2 Diabetes.

Invest Ophthalmol Vis Sci 2016 Oct;57(13):5518-5524

Department of Medicine, The University of Hong Kong, Hong Kong 4Research Center of Heart, Brain, Hormone and Healthy Aging, The University of Hong Kong, Hong Kong 5State Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, Hong Kong.

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http://dx.doi.org/10.1167/iovs.16-20094DOI Listing
October 2016

Predicting regulatory variants with composite statistic.

Bioinformatics 2016 09 6;32(18):2729-36. Epub 2016 Jun 6.

Centre for Genomic Sciences, Department of Health Sciences Research, Center for Individualized Medicine, Mayo Clinic, Scottsdale, AZ 85259, USA and Department of Biomedical Informatics, Arizona State University, Scottsdale, AZ 85259, USA.

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http://dx.doi.org/10.1093/bioinformatics/btw288DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6280872PMC
September 2016

Association of BDNF Polymorphisms with the Risk of Epilepsy: a Multicenter Study.

Mol Neurobiol 2016 07 16;53(5):2869-2877. Epub 2015 Apr 16.

Pharmacogenomics Laboratory, Department of Pharmacology, Faculty of Medicine, University of Malaya, Lembah Pantai, 59100, Kuala Lumpur, Malaysia.

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http://dx.doi.org/10.1007/s12035-015-9150-1DOI Listing
July 2016

Local True Discovery Rate Weighted Polygenic Scores Using GWAS Summary Data.

Behav Genet 2016 07 9;46(4):573-82. Epub 2016 Jan 9.

Centre for Genomic Sciences, University of Hong Kong, 5 Sassoon Road, Hong Kong, China.

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http://dx.doi.org/10.1007/s10519-015-9770-2DOI Listing
July 2016

A fast and powerful W-test for pairwise epistasis testing.

Nucleic Acids Res 2016 07 25;44(12):e115. Epub 2016 Apr 25.

Division of Biostatistics and Centre for Clinical Research and Biostatistics, JC School of Public Health and Primary Care, the Chinese University of Hong Kong, Shatin, N.T., Hong Kong SAR, China CUHK Shenzhen Research Institute, Shenzhen, China.

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http://dx.doi.org/10.1093/nar/gkw347DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4937324PMC
July 2016

The Effect of Oxytocin on Social and Non-Social Behaviour and Striatal Protein Expression in C57BL/6N Mice.

PLoS One 2015 30;10(12):e0145638. Epub 2015 Dec 30.

Department of Forensic and Neurodevelopmental Sciences, The Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0145638PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4696826PMC
June 2016

Novel pre-mRNA splicing of intronically integrated HBV generates oncogenic chimera in hepatocellular carcinoma.

J Hepatol 2016 06 8;64(6):1256-64. Epub 2016 Feb 8.

State Key Laboratory for Liver Research, The University of Hong Kong, Hong Kong; Department of Pathology, The University of Hong Kong, Hong Kong. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2016.02.005DOI Listing
June 2016

Whole-exome sequencing identifies MST1R as a genetic susceptibility gene in nasopharyngeal carcinoma.

Proc Natl Acad Sci U S A 2016 Mar 7;113(12):3317-22. Epub 2016 Mar 7.

Department of Clinical Oncology, University of Hong Kong, Hong Kong (Special Administrative Region), People's Republic of China; Center for Nasopharyngeal Carcinoma Research, University of Hong Kong, Hong Kong (Special Administrative Region), People's Republic of China;

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http://dx.doi.org/10.1073/pnas.1523436113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4812767PMC
March 2016

Psychiatric genetics in China: achievements and challenges.

Mol Psychiatry 2016 Jan 20;21(1):4-9. Epub 2015 Oct 20.

Neuropsychology and Applied Cognitive Neuroscience Laboratory, Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences.

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http://dx.doi.org/10.1038/mp.2015.95DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4830695PMC
January 2016

GWASdb v2: an update database for human genetic variants identified by genome-wide association studies.

Nucleic Acids Res 2016 Jan 28;44(D1):D869-76. Epub 2015 Nov 28.

Centre for Genomic Sciences, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China School of Biomedical Sciences, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China

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http://dx.doi.org/10.1093/nar/gkv1317DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4702921PMC
January 2016

Exome sequencing reveals a high genetic heterogeneity on familial Hirschsprung disease.

Sci Rep 2015 Nov 12;5:16473. Epub 2015 Nov 12.

Department of Genetics, Reproduction and Fetal Medicine, Institute of Biomedicine of Seville (IBIS), University Hospital Virgen del Rocío/CSIC/University of Seville, Seville, Spain.

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http://dx.doi.org/10.1038/srep16473DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4642299PMC
November 2015

SPS: A Simulation Tool for Calculating Power of Set-Based Genetic Association Tests.

Genet Epidemiol 2015 Jul 21;39(5):395-7. Epub 2015 May 21.

Department of Psychiatry, the University of Hong Kong, Pokfulam, Hong Kong.

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http://doi.wiley.com/10.1002/gepi.21898
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http://dx.doi.org/10.1002/gepi.21898DOI Listing
July 2015

PMCA4 (ATP2B4) mutation in familial spastic paraplegia.

PLoS One 2014 13;9(8):e104790. Epub 2014 Aug 13.

Division of Neurology, Department of Medicine, University of Hong Kong, Hong Kong, P. R. China; Research Centre of Heart, Brain, Hormone and Healthy Aging, University of Hong Kong, Hong Kong, P. R. China.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0104790PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4132067PMC
May 2015

wKGGSeq: A Comprehensive Strategy-Based and Disease-Targeted Online Framework to Facilitate Exome Sequencing Studies of Inherited Disorders.

Hum Mutat 2015 May 4;36(5):496-503. Epub 2015 Apr 4.

Centre for Genomic Sciences, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, SAR, China; Departments of Biochemistry, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, SAR, China; Shenzhen Institute of Research and Innovation, The University of Hong Kong, Shenzhen, Guangdong, 518057, China.

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http://dx.doi.org/10.1002/humu.22766DOI Listing
May 2015

HaploShare: identification of extended haplotypes shared by cases and evaluation against controls.

Genome Biol 2015 May 9;16:92. Epub 2015 May 9.

Department of Paediatrics and Adolescent Medicine, LKS Faculty of Medicine, The University of Hong Kong, 21 Sassoon Rd., Pokfulam, Hong Kong.

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http://dx.doi.org/10.1186/s13059-015-0662-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4432975PMC
May 2015

PMCA4 (ATP2B4) mutation in familial spastic paraplegia causes delay in intracellular calcium extrusion.

Brain Behav 2015 Apr 16;5(4):e00321. Epub 2015 Feb 16.

Division of Neurology, Department of Medicine, University of Hong Kong Hong Kong, China.

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http://dx.doi.org/10.1002/brb3.321DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4356846PMC
April 2015

HLAreporter: a tool for HLA typing from next generation sequencing data.

Genome Med 2015 16;7(1):25. Epub 2015 Mar 16.

Department of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Hong Kong, Hong Kong.

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http://dx.doi.org/10.1186/s13073-015-0145-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4407542PMC
April 2015

Functional variants regulating LGALS1 (Galectin 1) expression affect human susceptibility to influenza A(H7N9).

Sci Rep 2015 Feb 17;5:8517. Epub 2015 Feb 17.

1] State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, First Affiliated Hospital, College of Medicine, Zhejiang University [2] Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou, China.

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http://www.nature.com/articles/srep08517
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http://dx.doi.org/10.1038/srep08517DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4649671PMC
February 2015

Targeted next-generation sequencing on Hirschsprung disease: a pilot study exploits DNA pooling.

Ann Hum Genet 2014 Sep 20;78(5):381-7. Epub 2014 Jun 20.

Department of Surgery, The University of Hong Kong, Hong Kong, SAR, China; Department of Psychiatry, The University of Hong Kong, Hong Kong, SAR, China.

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http://dx.doi.org/10.1111/ahg.12076DOI Listing
September 2014

Common variants on Xq28 conferring risk of schizophrenia in Han Chinese.

Schizophr Bull 2014 Jul 16;40(4):777-86. Epub 2013 Sep 16.

Department of Psychiatry, The University of Hong Kong, Hong Kong, China; Centre for Genomic Sciences, The University of Hong Kong, Hong Kong, China; State Key Laboratory in Brain and Cognitive Sciences, The University of Hong Kong, Hong King, China;

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http://dx.doi.org/10.1093/schbul/sbt104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4059435PMC
July 2014

Genetic determinants of heel bone properties: genome-wide association meta-analysis and replication in the GEFOS/GENOMOS consortium.

Authors:
Alireza Moayyeri Yi-Hsiang Hsu David Karasik Karol Estrada Su-Mei Xiao Carrie Nielson Priya Srikanth Sylvie Giroux Scott G Wilson Hou-Feng Zheng Albert V Smith Stephen R Pye Paul J Leo Alexander Teumer Joo-Yeon Hwang Claes Ohlsson Fiona McGuigan Ryan L Minster Caroline Hayward José M Olmos Leo-Pekka Lyytikäinen Joshua R Lewis Karin M A Swart Laura Masi Chris Oldmeadow Elizabeth G Holliday Sulin Cheng Natasja M van Schoor Nicholas C Harvey Marcin Kruk Fabiola del Greco M Wilmar Igl Olivia Trummer Efi Grigoriou Robert Luben Ching-Ti Liu Yanhua Zhou Ling Oei Carolina Medina-Gomez Joseph Zmuda Greg Tranah Suzanne J Brown Frances M Williams Nicole Soranzo Johanna Jakobsdottir Kristin Siggeirsdottir Kate L Holliday Anke Hannemann Min Jin Go Melissa Garcia Ozren Polasek Marika Laaksonen Kun Zhu Anke W Enneman Mark McEvoy Roseanne Peel Pak Chung Sham Maciej Jaworski Åsa Johansson Andrew A Hicks Pawel Pludowski Rodney Scott Rosalie A M Dhonukshe-Rutten Nathalie van der Velde Mika Kähönen Jorma S Viikari Harri Sievänen Olli T Raitakari Jesús González-Macías Jose L Hernández Dan Mellström Osten Ljunggren Yoon Shin Cho Uwe Völker Matthias Nauck Georg Homuth Henry Völzke Robin Haring Matthew A Brown Eugene McCloskey Geoffrey C Nicholson Richard Eastell John A Eisman Graeme Jones Ian R Reid Elaine M Dennison John Wark Steven Boonen Dirk Vanderschueren Frederick C W Wu Thor Aspelund J Brent Richards Doug Bauer Albert Hofman Kay-Tee Khaw George Dedoussis Barbara Obermayer-Pietsch Ulf Gyllensten Peter P Pramstaller Roman S Lorenc Cyrus Cooper Annie Wai Chee Kung Paul Lips Markku Alen John Attia Maria Luisa Brandi Lisette C P G M de Groot Terho Lehtimäki José A Riancho Harry Campbell Yongmei Liu Tamara B Harris Kristina Akesson Magnus Karlsson Jong-Young Lee Henri Wallaschofski Emma L Duncan Terence W O'Neill Vilmundur Gudnason Timothy D Spector François Rousseau Eric Orwoll Steven R Cummings Nick J Wareham Fernando Rivadeneira Andre G Uitterlinden Richard L Prince Douglas P Kiel Jonathan Reeve Stephen K Kaptoge

Hum Mol Genet 2014 Jun 14;23(11):3054-68. Epub 2014 Jan 14.

Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1093/hmg/ddt675DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4038791PMC
June 2014

Prospective relationship between duration of untreated psychosis and 13-year clinical outcome: a first-episode psychosis study.

Schizophr Res 2014 Mar 11;153(1-3):1-8. Epub 2014 Feb 11.

Department of Psychiatry, The University of Hong Kong, Hong Kong; The State Key Laboratory of Brain and Cognitive Sciences, The University of Hong Kong, Hong Kong.

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http://dx.doi.org/10.1016/j.schres.2014.01.022DOI Listing
March 2014

dbPSHP: a database of recent positive selection across human populations.

Nucleic Acids Res 2014 Jan 4;42(Database issue):D910-6. Epub 2013 Nov 4.

Department of Biochemistry, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China, Shenzhen Institute of Research and Innovation, The University of Hong Kong, Shenzhen, Guangdong 518057, China, Department of Anaesthesiology, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China, Department of Pathology, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China, Department of Psychiatry, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China, State Key Laboratory in Cognitive and Brain Sciences, The University of Hong Kong, Hong Kong SAR, China and Centre for Genomic Sciences, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.

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http://dx.doi.org/10.1093/nar/gkt1052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3965004PMC
January 2014

Genetic variant in vitamin D binding protein is associated with serum 25-hydroxyvitamin D and vitamin D insufficiency in southern Chinese.

J Hum Genet 2013 Nov 8;58(11):749-51. Epub 2013 Aug 8.

1] Department of Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, China [2] Centre for Genomic Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, China [3] Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, China.

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http://dx.doi.org/10.1038/jhg.2013.84DOI Listing
November 2013

Genetic variants in GREM2 are associated with bone mineral density in a southern Chinese population.

J Clin Endocrinol Metab 2013 Sep 31;98(9):E1557-61. Epub 2013 Jul 31.

Department of Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, China.

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http://dx.doi.org/10.1210/jc.2013-1983DOI Listing
September 2013

GWAS3D: Detecting human regulatory variants by integrative analysis of genome-wide associations, chromosome interactions and histone modifications.

Nucleic Acids Res 2013 Jul 30;41(Web Server issue):W150-8. Epub 2013 May 30.

Department of Biochemistry, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.

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http://dx.doi.org/10.1093/nar/gkt456DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3692118PMC
July 2013

A fast and accurate SNP detection algorithm for next-generation sequencing data.

Nat Commun 2012 ;3:1258

Department of Biochemistry, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China.

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http://dx.doi.org/10.1038/ncomms2256DOI Listing
June 2013

Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians.

Am J Hum Genet 2013 Jan 27;92(1):41-51. Epub 2012 Dec 27.

Department of Paediatrics and Adolescent Medicine, Queen Mary Hospital, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Hong Kong.

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http://dx.doi.org/10.1016/j.ajhg.2012.11.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3542470PMC
January 2013

Assessment of gene-by-sex interaction effect on bone mineral density.

J Bone Miner Res 2012 Oct;27(10):2051-64

Department of Biostatistics, Boston University School of Public Health, 801 Massachusetts Avenue CT3, Boston,MA 02118, USA.

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http://dx.doi.org/10.1002/jbmr.1679DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3447125PMC
October 2012