Paivi Peltomaki

Paivi Peltomaki

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Paivi Peltomaki

Paivi Peltomaki

Publications by authors named "Paivi Peltomaki"

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91Publications

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Biallelic germline nonsense variant of MLH3 underlies polyposis predisposition.

Genet Med 2019 Aug 21;21(8):1868-1873. Epub 2018 Dec 21.

Department of Medical and Clinical Genetics, Medicum, University of Helsinki, Helsinki, Finland.

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http://www.nature.com/articles/s41436-018-0405-x
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http://dx.doi.org/10.1038/s41436-018-0405-xDOI Listing
August 2019

Epidemiological, clinical and molecular characterization of Lynch-like syndrome: A population-based study.

Int J Cancer 2019 Jul 7;145(1):87-98. Epub 2019 Jan 7.

Department of Medical and Clinical Genetics, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1002/ijc.32085DOI Listing
July 2019

Molecular changes preceding endometrial and ovarian cancer: a study of consecutive endometrial specimens from Lynch syndrome surveillance.

Mod Pathol 2018 08 27;31(8):1291-1301. Epub 2018 Mar 27.

Department of Medical and Clinical Genetics, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1038/s41379-018-0044-4DOI Listing
August 2018

Converging endometrial and ovarian tumorigenesis in Lynch syndrome: Shared origin of synchronous carcinomas.

Gynecol Oncol 2018 07 30;150(1):92-98. Epub 2018 Apr 30.

Department of Medical and Clinical Genetics, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1016/j.ygyno.2018.04.566DOI Listing
July 2018

Disorders of DNA repair mechanisms and their clinical significance.

Duodecim 2017;133(3):259-5

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January 2018

Sequencing of Lynch syndrome tumors reveals the importance of epigenetic alterations.

Oncotarget 2017 Dec 14;8(64):108020-108030. Epub 2017 Nov 14.

Department of Medical and Clinical Genetics, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.18632/oncotarget.22445DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5746122PMC
December 2017

MicroRNA Methylation in Colorectal Cancer.

Adv Exp Med Biol 2016;937:109-22

Department of Medical and Clinical Genetics, University of Helsinki, Helsinki, Finland.

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http://link.springer.com/10.1007/978-3-319-42059-2_6
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http://dx.doi.org/10.1007/978-3-319-42059-2_6DOI Listing
July 2017

Update on Lynch syndrome genomics.

Fam Cancer 2016 07;15(3):385-93

Department of Medical and Clinical Genetics, University of Helsinki, P. O. Box 63, Haartmaninkatu 8, 00014, Helsinki, Finland.

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http://link.springer.com/10.1007/s10689-016-9882-8
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http://dx.doi.org/10.1007/s10689-016-9882-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4901089PMC
July 2016

Desmoid tumor patients carry an elevated risk of familial adenomatous polyposis.

J Surg Oncol 2016 Feb 10;113(2):209-12. Epub 2015 Dec 10.

Department of Colorectal Surgery, Abdominal Center, Helsinki University Hospital, Helsinki, Finland.

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http://dx.doi.org/10.1002/jso.24117DOI Listing
February 2016

Methyltransferase expression and tumor suppressor gene methylation in sporadic and familial colorectal cancer.

Genes Chromosomes Cancer 2015 Dec 25;54(12):776-87. Epub 2015 Aug 25.

Department of Medical and Clinical Genetics, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1002/gcc.22289DOI Listing
December 2015

Identification of subgroup-specific miRNA patterns by epigenetic profiling of sporadic and Lynch syndrome-associated colorectal and endometrial carcinoma.

Clin Epigenetics 2015 10;7:20. Epub 2015 Mar 10.

Department of Medical Genetics, Biomedicum Helsinki, University of Helsinki, Haartmaninkatu 8, P.O. Box 63, Helsinki, FIN-00014 Finland.

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http://dx.doi.org/10.1186/s13148-015-0059-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4357086PMC
March 2015

Reply: To PMID 24941021.

Gastroenterology 2015 Jan 22;148(1):259. Epub 2014 Nov 22.

Department of Medical Genetics, Haartman Institute, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1053/j.gastro.2014.11.028DOI Listing
January 2015

Loss of p15INK⁴b expression in colorectal cancer is linked to ethnic origin.

Asian Pac J Cancer Prev 2014 ;15(5):2083-7

College of Health Sciences, University of Sharjah, and Sharjah Institute for Medical Research, Sharjah, United Arab Emirates E-mail :

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http://dx.doi.org/10.7314/apjcp.2014.15.5.2083DOI Listing
December 2014

Promoter-specific alterations of APC are a rare cause for mutation-negative familial adenomatous polyposis.

Genes Chromosomes Cancer 2014 Oct 20;53(10):857-64. Epub 2014 Jun 20.

Department of Medical Genetics, Haartman Institute, University of Helsinki, Helsinki, Finland; Laboratorio de Citogenética y Mutagénesis, Instituto Multidisciplinario de Biología Celular (IMBICE-CONICET-CICPBA), La Plata, Argentina.

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http://dx.doi.org/10.1002/gcc.22197DOI Listing
October 2014

3'-UTR poly(T/U) tract deletions and altered expression of EWSR1 are a hallmark of mismatch repair-deficient cancers.

Cancer Res 2014 Jan 24;74(1):224-34. Epub 2013 Oct 24.

Authors' Affiliations: Biozentrum, University of Basel; Research Group Human Genetics, Dept of Biomedicine, University of Basel, and Division of Medical Genetics, University Hospital Basel; Institute for Surgical Research and Hospital Management and Department of Biomedicine, University of Basel; Institute of Pathology, University Hospital of Basel, Basel; Pathologie Laenggasse Bern, Bern; Institute of Molecular Cancer Research, University of Zurich, Zurich, Switzerland; Department of Medical Genetics, Haartman Institute, University of Helsinki, Helsinki, Finland; and Paterson Institute for Cancer Research, University of Manchester, Manchester, United Kingdom.

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http://dx.doi.org/10.1158/0008-5472.CAN-13-2100DOI Listing
January 2014

Psychosocial consequences of predictive genetic testing for Lynch syndrome and associations to surveillance behaviour in a 7-year follow-up study.

Fam Cancer 2013 Dec;12(4):639-46

Department of Medical Genetics, Haartman Institute Biomedicum, University of Helsinki, PO Box 63, FIN-00014, Helsinki, Finland,

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http://link.springer.com/10.1007/s10689-013-9628-9
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http://dx.doi.org/10.1007/s10689-013-9628-9DOI Listing
December 2013

Distinct molecular profiles in Lynch syndrome-associated and sporadic ovarian carcinomas.

Int J Cancer 2013 Dec 21;133(11):2596-608. Epub 2013 Jun 21.

Department of Medical Genetics, Haartman Institute, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1002/ijc.28287DOI Listing
December 2013

BRAF mutation in sporadic colorectal cancer and Lynch syndrome.

Virchows Arch 2013 Nov 21;463(5):613-21. Epub 2013 Aug 21.

Division of Pathology and Genetics, HUSLAB, and Haartman Institute, Helsinki University Central Hospital and University of Helsinki, P.O. Box 400, Helsinki, FIN-00029 HUS, Finland.

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http://link.springer.com/content/pdf/10.1007/s00428-013-1470
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http://link.springer.com/10.1007/s00428-013-1470-9
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http://dx.doi.org/10.1007/s00428-013-1470-9DOI Listing
November 2013

Uroepithelial and kidney carcinoma in Lynch syndrome.

Fam Cancer 2012 Sep;11(3):395-401

Department of Surgery, Jyväskylä Central Hospital, Jyväskylä, Finland.

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http://link.springer.com/10.1007/s10689-012-9526-6
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http://dx.doi.org/10.1007/s10689-012-9526-6DOI Listing
September 2012

Differential roles of EPS8 in carcinogenesis: loss of protein expression in a subset of colorectal carcinoma and adenoma.

World J Gastroenterol 2012 Aug;18(29):3896-903

Department of Medical Laboratory Sciences, College of Health Sciences, University of Sharjah, Sharjah, United Arab Emirates.

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http://www.wjgnet.com/1007-9327/full/v18/i29/3896.htm
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http://dx.doi.org/10.3748/wjg.v18.i29.3896DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3413063PMC
August 2012

LINE-1 hypomethylation in familial and sporadic cancer.

J Mol Med (Berl) 2012 Jul 8;90(7):827-35. Epub 2012 Jan 8.

Department of Medical Genetics, Haartman Institute, University of Helsinki, Helsinki, PO Box 63 00014, Finland.

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http://link.springer.com/10.1007/s00109-011-0854-z
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http://dx.doi.org/10.1007/s00109-011-0854-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3383956PMC
July 2012

[Epigenetic modifications in cancer].

Duodecim 2012 ;128(1):62-71

Lääketieteellinen genetiikka, Haartman-instituutti.

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April 2012

Mutations and epimutations in the origin of cancer.

Exp Cell Res 2012 Feb 13;318(4):299-310. Epub 2011 Dec 13.

Department of Medical Genetics, Haartman Institute, P. O. Box 63 (Haartmaninkatu 8), FI-00014 University of Helsinki, Finland.

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http://dx.doi.org/10.1016/j.yexcr.2011.12.001DOI Listing
February 2012

Distinct genetic and epigenetic signatures of colorectal cancers according to ethnic origin.

Cancer Epidemiol Biomarkers Prev 2012 Jan 25;21(1):202-11. Epub 2011 Oct 25.

Department of Medical Genetics, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1158/1055-9965.EPI-11-0662DOI Listing
January 2012

Pathogenesis of endometriosis and its relationship to gynecological cancers.

Epigenomics 2011 Dec;3(6):689-90

Departments of Obstetrics, Gynecology & Pathology, Helsinki University Central Hospital, Helsinki, Finland.

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http://dx.doi.org/10.2217/epi.11.96DOI Listing
December 2011

Endometriosis as an epigenetic disease.

Epigenomics 2011 Dec;3(6):690-1

Departments of Obstetrics, Gynecology & Pathology, Helsinki University Central Hospital, Helsinki, Finland.

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December 2011

Epigenetic events in endometrial tumorigenesis.

Epigenomics 2011 Dec;3(6):691

Departments of Obstetrics, Gynecology & Pathology, Helsinki University Central Hospital, Helsinki, Finland.

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December 2011

Reducing the risk of type 2 diabetes with nutrition and physical activity - efficacy and implementation of lifestyle interventions in Finland.

Public Health Nutr 2010 Jun;13(6A):993-9

National Institute for Health and Welfare, Diabetes Prevention Unit, PO Box 30, FI-00271 Helsinki, Finland.

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http://dx.doi.org/10.1017/S1368980010000960DOI Listing
June 2010

Ten years after mutation testing for Lynch syndrome: cancer incidence and outcome in mutation-positive and mutation-negative family members.

J Clin Oncol 2009 Oct 31;27(28):4793-7. Epub 2009 Aug 31.

Department of Surgery, University of Helsinki, FI-00029 HUS, Helsinki, Finland.

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http://dx.doi.org/10.1200/JCO.2009.23.7784DOI Listing
October 2009

Lynch syndrome and related familial colorectal cancers.

Crit Rev Oncog 2008 ;14(1):1-22; discussion 23-31

Department of Medical Laboratory Technology, College of Health Sciences, University of Sharjah, Sharjah, United Arab Emirates.

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January 2009

Clinicopathological characterization and genomic aberrations in subcutaneous panniculitis-like T-cell lymphoma.

J Invest Dermatol 2008 Sep 13;128(9):2304-9. Epub 2008 Mar 13.

Department of Dermatology and Allergology, Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1038/jid.2008.6DOI Listing
September 2008

Epigenetic signatures of familial cancer are characteristic of tumor type and family category.

Cancer Res 2008 Jun;68(12):4597-605

Department of Medical Genetics, University of Helsinki, Finland.

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http://dx.doi.org/10.1158/0008-5472.CAN-07-6645DOI Listing
June 2008

Truncation of MBD4 predisposes to reciprocal chromosomal translocations and alters the response to therapeutic agents in colon cancer cells.

DNA Repair (Amst) 2008 Feb 26;7(2):321-8. Epub 2007 Dec 26.

Department of Medical Genetics, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1016/j.dnarep.2007.11.009DOI Listing
February 2008

Development of colorectal tumors in colonoscopic surveillance in Lynch syndrome.

Gastroenterology 2007 Oct 14;133(4):1093-8. Epub 2007 Aug 14.

Department of Surgery, Jyväskylä Central Hospital, Jyväskylä, Finland.

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http://dx.doi.org/10.1053/j.gastro.2007.08.019DOI Listing
October 2007

Patterns of PIK3CA alterations in familial colorectal and endometrial carcinoma.

Int J Cancer 2007 Aug;121(4):915-20

Department of Medical Genetics, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1002/ijc.22768DOI Listing
August 2007

The genetics of HNPCC: application to diagnosis and screening.

Crit Rev Oncol Hematol 2006 Jun 23;58(3):208-20. Epub 2006 Jan 23.

Department of Medical Genetics, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1016/j.critrevonc.2005.11.001DOI Listing
June 2006

Gene conversion is a frequent mechanism of inactivation of the wild-type allele in cancers from MLH1/MSH2 deletion carriers.

Cancer Res 2006 Jan;66(2):659-64

Research Group Human Genetics, Division of Medical Genetics UKBB, Center of Biomedicine DKBW, University of Basel, Mattenstrasse 28, 4058 Basel, Switzerland.

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http://cancerres.aacrjournals.org/lookup/doi/10.1158/0008-54
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http://dx.doi.org/10.1158/0008-5472.CAN-05-4043DOI Listing
January 2006

Lynch syndrome genes.

Fam Cancer 2005 ;4(3):227-32

Department of Medical Genetics, Biomedicum Helsinki, University of Helsinki, P.O. Box 63, Haartmaninkatu 8, 00014, Finland.

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http://dx.doi.org/10.1007/s10689-004-7993-0DOI Listing
December 2005

p53 codon 72 and MDM2 SNP309 polymorphisms and age of colorectal cancer onset in Lynch syndrome.

Clin Cancer Res 2005 Oct;11(19 Pt 1):6840-4

Human Cancer Genetics Program, Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43210, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-05-1139DOI Listing
October 2005

APC and beta-catenin protein expression patterns in HNPCC-related endometrial and colorectal cancers.

Fam Cancer 2005 ;4(2):187-90

Department of Biological and Environmental Sciences, Genetics, University of Helsinki, Viikinkaari 5, 00014 Helsinki, Finland.

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http://link.springer.com/10.1007/s10689-004-6130-4
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http://dx.doi.org/10.1007/s10689-004-6130-4DOI Listing
September 2005

Adenomatous polyposis families that screen APC mutation-negative by conventional methods are genetically heterogeneous.

J Clin Oncol 2005 Aug;23(24):5651-9

Department of Medical Genetics, Institute of Dentistry, Biomedicum Helsinki, PO Box 63 (Haartmaninkatu 8), FIN-00014 University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1200/JCO.2005.14.712DOI Listing
August 2005

Mutations associated with HNPCC predisposition -- Update of ICG-HNPCC/INSiGHT mutation database.

Dis Markers 2004 ;20(4-5):269-76

Department of Medical Genetics, University of Helsinki, Helsinki, Finland.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3839397PMC
http://dx.doi.org/10.1155/2004/305058DOI Listing
May 2005

Molecular basis and diagnostics of hereditary colorectal cancers.

Ann Med 2004 ;36(5):379-88

Department of Medical Genetics, University of Helsinki, Helsinki, Finland. Wael.Abdel-Rahman@helsinki

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March 2005

The complex genotype-phenotype relationship in familial adenomatous polyposis.

Eur J Gastroenterol Hepatol 2004 Jan;16(1):5-8

Department of Gastroenterological Surgery, Helsinki University Central Hospital, Helsinki, Finland.

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http://dx.doi.org/10.1097/00042737-200401000-00002DOI Listing
January 2004

Little evidence for involvement of MLH3 in colorectal cancer predisposition.

Int J Cancer 2003 Aug;106(2):292-6

Department of Medical Genetics, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1002/ijc.11218DOI Listing
August 2003

Y chromosome instability in lymphoproliferative disorders.

Mutat Res 2003 Apr;525(1-2):103-7

Instituto Multidisciplinario de Biología Celular, Calle 526 e/10 y 11, CC 403, 1900 La Plata, Argentina.

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http://dx.doi.org/10.1016/s0027-5107(03)00007-1DOI Listing
April 2003

Three new mutations in hereditary nonpolyposis colorectal cancer (Lynch syndrome II) in Uruguay.

Cancer Genet Cytogenet 2003 Apr;142(1):13-20

Uruguayan Collaborative Group: Survey of Hereditary Oncologic Disorders, Hospital Central de las Fuerzas Armadas, 11600 Montevideo, Uruguay.

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http://dx.doi.org/10.1016/s0165-4608(02)00766-5DOI Listing
April 2003

Role of DNA mismatch repair defects in the pathogenesis of human cancer.

J Clin Oncol 2003 Mar;21(6):1174-9

Department of Medical Genetics, University of Helsinki, Finland.

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http://ascopubs.org/doi/10.1200/JCO.2003.04.060
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http://dx.doi.org/10.1200/JCO.2003.04.060DOI Listing
March 2003

Occupational health services and maintenance of work ability at workplaces.

Arh Hig Rada Toksikol 2002 Dec;53(4):263-74

Finnish Institute of Occupational Health, FIOH, Department of Epidemiology and Biostatistics, Topeliuksenkatu 41 A, FIN-00250 Helsinki.

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December 2002

Networking between occupational health services, client enterprises and other experts: difficulties, supporting factors and benefits.

Int J Occup Med Environ Health 2002 ;15(2):139-45

Department of Research and Development in Occupational Health Services, Finnish Institute of Occupational Health, Helsinki.

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October 2002

PTEN mutational spectra, expression levels, and subcellular localization in microsatellite stable and unstable colorectal cancers.

Am J Pathol 2002 Aug;161(2):439-47

Clinical Cancer Genetics Program, Comprehensive Cancer Center and the Division of Human Genetics, Department of Internal Medicine, The Ohio State University, Columbus, Ohio 43210, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1850747PMC
http://dx.doi.org/10.1016/S0002-9440(10)64200-9DOI Listing
August 2002

Genome profiles of familial/bilateral and sporadic testicular germ cell tumors.

Genes Chromosomes Cancer 2002 Jun;34(2):168-74

Department of Genetics, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo, Norway.

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http://dx.doi.org/10.1002/gcc.10058DOI Listing
June 2002

Mosaic AZF deletions and susceptibility to testicular tumors.

Mutat Res 2002 Jun;503(1-2):51-62

Instituto Multidisciplinario de Biología Celular (IMBICE), La Plata, Argentina.

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http://dx.doi.org/10.1016/s0027-5107(02)00072-6DOI Listing
June 2002

Distinct epigenetic phenotypes in seminomatous and nonseminomatous testicular germ cell tumors.

Oncogene 2002 May;21(24):3909-16

Division of Human Cancer Genetics, Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University, 420 West 12th Avenue, Columbus, OH 43210, USA.

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http://dx.doi.org/10.1038/sj.onc.1205488DOI Listing
May 2002

Distinct PTEN mutational spectra in hereditary non-polyposis colon cancer syndrome-related endometrial carcinomas compared to sporadic microsatellite unstable tumors.

Hum Mol Genet 2002 Feb;11(4):445-50

Clinical Cancer Genetics Program and Human Cancer Genetics Program, Comprehensive Cancer Center and Division of Human Genetics, Department of Internal Medicine, The Ohio State University, Columbus, OH 43210, USA.

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http://dx.doi.org/10.1093/hmg/11.4.445DOI Listing
February 2002