Publications by authors named "Padmanee Sharma"

138 Publications

Neoadjuvant nivolumab or nivolumab plus ipilimumab in operable non-small cell lung cancer: the phase 2 randomized NEOSTAR trial.

Authors:
Tina Cascone William N William Annikka Weissferdt Cheuk H Leung Heather Y Lin Apar Pataer Myrna C B Godoy Brett W Carter Lorenzo Federico Alexandre Reuben Md Abdul Wadud Khan Hitoshi Dejima Alejandro Francisco-Cruz Edwin R Parra Luisa M Solis Junya Fujimoto Hai T Tran Neda Kalhor Frank V Fossella Frank E Mott Anne S Tsao George Blumenschein Xiuning Le Jianjun Zhang Ferdinandos Skoulidis Jonathan M Kurie Mehmet Altan Charles Lu Bonnie S Glisson Lauren Averett Byers Yasir Y Elamin Reza J Mehran David C Rice Garrett L Walsh Wayne L Hofstetter Jack A Roth Mara B Antonoff Humam Kadara Cara Haymaker Chantale Bernatchez Nadim J Ajami Robert R Jenq Padmanee Sharma James P Allison Andrew Futreal Jennifer A Wargo Ignacio I Wistuba Stephen G Swisher J Jack Lee Don L Gibbons Ara A Vaporciyan John V Heymach Boris Sepesi

Nat Med 2021 Feb 18. Epub 2021 Feb 18.

Thoracic and Cardiovascular Surgery, University of Texas MD Anderson Cancer Center, Houston, TX, USA.

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February 2021

A Genetic Mouse Model Recapitulates Immune Checkpoint Inhibitor-Associated Myocarditis and Supports a Mechanism-Based Therapeutic Intervention.

Authors:
Spencer C Wei Wouter C Meijers Margaret L Axelrod Nana-Ama A S Anang Elles M Screever Elizabeth C Wescott Douglas B Johnson Elizabeth Whitley Lorenz Lehmann Pierre-Yves Courand James J Mancuso Lauren E Himmel Benedicte Lebrun-Vignes Matthew J Wleklinski Bjorn C Knollmann Jayashree Srinivasan Yu Li Oluwatomisin T Atolagbe Xiayu Rao Yang Zhao Jing Wang Lauren I R Ehrlich Padmanee Sharma Joe-Elie Salem Justin M Balko Javid J Moslehi James P Allison

Cancer Discov 2020 Nov 30. Epub 2020 Nov 30.

Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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November 2020

Outcomes of patients with metastatic renal cell carcinoma with sarcomatoid dedifferentiation to immune checkpoint inhibitors.

Authors:
Jad Chahoud Pavlos Msaouel Jeremy A Ross Barrett Z McCormick Tharakeswara K Bathala Jianjun Gao Robert Horn Lianchun Xiao Kanishka Sircar Matthew T Campbell Amishi Y Shah Sangeeta Goswami Amado J Zurita Eric Jonasch Surena F Matin Christopher G Wood Jose A Karam Padmanee Sharma Nizar M Tannir

Urol Oncol 2021 Feb 10;39(2):134.e9-134.e16. Epub 2020 Nov 10.

The University of Texas MD Anderson Cancer Center, Houston, TX. Electronic address:

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February 2021

Rationale and Outcomes for Neoadjuvant Immunotherapy in Urothelial Carcinoma of the Bladder.

Authors:
Mathieu Rouanne Dean F Bajorin Raquibul Hannan Matthew D Galsky Stephen B Williams Andrea Necchi Padmanee Sharma Thomas Powles

Eur Urol Oncol 2020 12 8;3(6):728-738. Epub 2020 Nov 8.

Experimental Cancer Medicine Centre Barts Cancer Institute, Queen Mary University of London, St Bartholomew's Hospital, London, UK.

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December 2020

Neoadjuvant PD-L1 plus CTLA-4 blockade in patients with cisplatin-ineligible operable high-risk urothelial carcinoma.

Authors:
Jianjun Gao Neema Navai Omar Alhalabi Arlene Siefker-Radtke Matthew T Campbell Rebecca Slack Tidwell Charles C Guo Ashish M Kamat Surena F Matin John C Araujo Amishi Y Shah Pavlos Msaouel Paul Corn Jianbo Wang John N Papadopoulos Shalini S Yadav Jorge M Blando Fei Duan Sreyashi Basu Wenbin Liu Yu Shen Yuwei Zhang Marc Daniel Macaluso Ying Wang Jianfeng Chen Jianhua Zhang Andrew Futreal Colin Dinney James P Allison Sangeeta Goswami Padmanee Sharma

Nat Med 2020 12 12;26(12):1845-1851. Epub 2020 Oct 12.

Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

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December 2020

Nivolumab Plus Ipilimumab for Metastatic Castration-Resistant Prostate Cancer: Preliminary Analysis of Patients in the CheckMate 650 Trial.

Authors:
Padmanee Sharma Russell K Pachynski Vivek Narayan Aude Fléchon Gwenaelle Gravis Matthew D Galsky Hakim Mahammedi Akash Patnaik Sumit K Subudhi Marika Ciprotti Burcin Simsek Abdel Saci Yanhua Hu G Celine Han Karim Fizazi

Cancer Cell 2020 10 10;38(4):489-499.e3. Epub 2020 Sep 10.

Department of Cancer Medicine, Gustave Roussy, University of Paris Saclay, 94800 Villejuif, France.

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October 2020

mutation plus CXCL13 expression act as combinatorial biomarkers to predict responses to immune checkpoint therapy in mUCC.

Authors:
Sangeeta Goswami Yulong Chen Swetha Anandhan Peter M Szabo Sreyashi Basu Jorge M Blando Wenbin Liu Jan Zhang Seanu Meena Natarajan Liangwen Xiong Baoxiang Guan Shalini Singh Yadav Abdel Saci James P Allison Matthew D Galsky Padmanee Sharma

Sci Transl Med 2020 06;12(548)

Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

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June 2020

Nivolumab in Patients with Advanced Platinum-resistant Urothelial Carcinoma: Efficacy, Safety, and Biomarker Analyses with Extended Follow-up from CheckMate 275.

Authors:
Matthew D Galsky Abdel Saci Peter M Szabo G Celine Han Gary Grossfeld Sandra Collette Arlene Siefker-Radtke Andrea Necchi Padmanee Sharma

Clin Cancer Res 2020 Oct 12;26(19):5120-5128. Epub 2020 Jun 12.

MD Anderson Cancer Center, University of Texas, Houston, Texas.

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October 2020

Comprehensive Molecular Characterization Identifies Distinct Genomic and Immune Hallmarks of Renal Medullary Carcinoma.

Authors:
Pavlos Msaouel Gabriel G Malouf Xiaoping Su Hui Yao Durga N Tripathi Melinda Soeung Jianjun Gao Priya Rao Cristian Coarfa Chad J Creighton Jean-Philippe Bertocchio Selvi Kunnimalaiyaan Asha S Multani Jorge Blando Rong He Daniel D Shapiro Luigi Perelli Sanjana Srinivasan Federica Carbone Patrick G Pilié Menuka Karki Riyad N H Seervai Bujamin H Vokshi Dolores Lopez-Terrada Emily H Cheng Ximing Tang Wei Lu Ignacio I Wistuba Timothy C Thompson Irwin Davidson Virginia Giuliani Katharina Schlacher Alessandro Carugo Timothy P Heffernan Padmanee Sharma Jose A Karam Christopher G Wood Cheryl L Walker Giannicola Genovese Nizar M Tannir

Cancer Cell 2020 05 30;37(5):720-734.e13. Epub 2020 Apr 30.

Department of Genitourinary Medical Oncology, Unit 1374, The University of Texas MD Anderson Cancer Center, 1155 Pressler Street, Houston, TX 77030-3721, USA. Electronic address:

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May 2020

Spatially resolved analyses link genomic and immune diversity and reveal unfavorable neutrophil activation in melanoma.

Authors:
Akash Mitra Miles C Andrews Whijae Roh Marianna Petaccia De Macedo Courtney W Hudgens Fernando Carapeto Shailbala Singh Alexandre Reuben Feng Wang Xizeng Mao Xingzhi Song Khalida Wani Samantha Tippen Kwok-Shing Ng Aislyn Schalck Donald A Sakellariou-Thompson Eveline Chen Sangeetha M Reddy Christine N Spencer Diana Wiesnoski Latasha D Little Curtis Gumbs Zachary A Cooper Elizabeth M Burton Patrick Hwu Michael A Davies Jianhua Zhang Chantale Bernatchez Nicholas Navin Padmanee Sharma James P Allison Jennifer A Wargo Cassian Yee Michael T Tetzlaff Wen-Jen Hwu Alexander J Lazar P Andrew Futreal

Nat Commun 2020 04 15;11(1):1839. Epub 2020 Apr 15.

Department of Genomic Medicine, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

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April 2020

Neoantigen responses, immune correlates, and favorable outcomes after ipilimumab treatment of patients with prostate cancer.

Authors:
Sumit K Subudhi Luis Vence Hao Zhao Jorge Blando Shalini S Yadav Qing Xiong Alexandre Reuben Ana Aparicio Paul G Corn Brian F Chapin Louis L Pisters Patricia Troncoso Rebecca Slack Tidwell Peter Thall Chang-Jiun Wu Jianhua Zhang Christopher L Logothetis Andrew Futreal James P Allison Padmanee Sharma

Sci Transl Med 2020 04;12(537)

Department of Genitourinary Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

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April 2020

Nivolumab for the Treatment of Patients with Metastatic Non-Clear Cell Renal Cell Carcinoma (nccRCC): A Single-Institutional Experience and Literature Meta-Analysis.

Authors:
Jad Chahoud Pavlos Msaouel Matthew T Campbell Tharakeswara Bathala Lianchun Xiao Jianjun Gao Amado J Zurita Amishi Yogesh Shah Eric Jonasch Padmanee Sharma Nizar M Tannir

Oncologist 2020 03 9;25(3):252-258. Epub 2019 Sep 9.

The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

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March 2020

Posttransplantation cyclophosphamide improves transplantation outcomes in patients with AML/MDS who are treated with checkpoint inhibitors.

Authors:
Betül Oran Guillermo Garcia-Manero Rima M Saliba Mansour Alfayez Gheath Al-Atrash Stefan O Ciurea Elias J Jabbour Rohtesh S Mehta Uday R Popat Farhad Ravandi Amin M Alousi Tapan M Kadia Marina Konopleva Courtney D DiNardo Katy Rezvani Elizabeth J Shpall Padmanee Sharma Hagop M Kantarjian Richard E Champlin Naval Daver

Cancer 2020 05 3;126(10):2193-2205. Epub 2020 Mar 3.

Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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May 2020

Comprehensive T cell repertoire characterization of non-small cell lung cancer.

Authors:
Alexandre Reuben Jiexin Zhang Shin-Heng Chiou Rachel M Gittelman Jun Li Won-Chul Lee Junya Fujimoto Carmen Behrens Xiaoke Liu Feng Wang Kelly Quek Chunlin Wang Farrah Kheradmand Runzhe Chen Chi-Wan Chow Heather Lin Chantale Bernatchez Ali Jalali Xin Hu Chang-Jiun Wu Agda Karina Eterovic Edwin Roger Parra Erik Yusko Ryan Emerson Sharon Benzeno Marissa Vignali Xifeng Wu Yuanqing Ye Latasha D Little Curtis Gumbs Xizeng Mao Xingzhi Song Samantha Tippen Rebecca L Thornton Tina Cascone Alexandra Snyder Jennifer A Wargo Roy Herbst Stephen Swisher Humam Kadara Cesar Moran Neda Kalhor Jianhua Zhang Paul Scheet Ara A Vaporciyan Boris Sepesi Don L Gibbons Harlan Robins Patrick Hwu John V Heymach Padmanee Sharma James P Allison Veera Baladandayuthapani Jack J Lee Mark M Davis Ignacio I Wistuba P Andrew Futreal Jianjun Zhang

Nat Commun 2020 01 30;11(1):603. Epub 2020 Jan 30.

Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe, Houston, TX, 77030, USA.

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January 2020

B cells and tertiary lymphoid structures promote immunotherapy response.

Authors:
Beth A Helmink Sangeetha M Reddy Jianjun Gao Shaojun Zhang Rafet Basar Rohit Thakur Keren Yizhak Moshe Sade-Feldman Jorge Blando Guangchun Han Vancheswaran Gopalakrishnan Yuanxin Xi Hao Zhao Rodabe N Amaria Hussein A Tawbi Alex P Cogdill Wenbin Liu Valerie S LeBleu Fernanda G Kugeratski Sapna Patel Michael A Davies Patrick Hwu Jeffrey E Lee Jeffrey E Gershenwald Anthony Lucci Reetakshi Arora Scott Woodman Emily Z Keung Pierre-Olivier Gaudreau Alexandre Reuben Christine N Spencer Elizabeth M Burton Lauren E Haydu Alexander J Lazar Roberta Zapassodi Courtney W Hudgens Deborah A Ledesma SuFey Ong Michael Bailey Sarah Warren Disha Rao Oscar Krijgsman Elisa A Rozeman Daniel Peeper Christian U Blank Ton N Schumacher Lisa H Butterfield Monika A Zelazowska Kevin M McBride Raghu Kalluri James Allison Florent Petitprez Wolf Herman Fridman Catherine Sautès-Fridman Nir Hacohen Katayoun Rezvani Padmanee Sharma Michael T Tetzlaff Linghua Wang Jennifer A Wargo

Nature 2020 01 15;577(7791):549-555. Epub 2020 Jan 15.

Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

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January 2020

Dissecting the mechanisms of immune checkpoint therapy.

Authors:
Padmanee Sharma James P Allison

Nat Rev Immunol 2020 02;20(2):75-76

Department of Immunology, The University of Texas, MD Anderson Cancer Center, Houston, TX, USA.

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February 2020

Immune profiling of human tumors identifies CD73 as a combinatorial target in glioblastoma.

Authors:
Sangeeta Goswami Thomas Walle Andrew E Cornish Sreyashi Basu Swetha Anandhan Irina Fernandez Luis Vence Jorge Blando Hao Zhao Shalini Singh Yadav Martina Ott Ling Y Kong Amy B Heimberger John de Groot Boris Sepesi Michael Overman Scott Kopetz James P Allison Dana Pe'er Padmanee Sharma

Nat Med 2020 01 23;26(1):39-46. Epub 2019 Dec 23.

Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

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January 2020

High OX-40 expression in the tumor immune infiltrate is a favorable prognostic factor of overall survival in non-small cell lung cancer.

Authors:
Erminia Massarelli Vincent K Lam Edwin R Parra Jaime Rodriguez-Canales Carmen Behrens Lixia Diao Jing Wang Jorge Blando Lauren A Byers Niranjan Yanamandra Sara Brett Peter Morley Padmanee Sharma James Allison Ignacio I Wistuba John V Heymach

J Immunother Cancer 2019 12 16;7(1):351. Epub 2019 Dec 16.

Department of Thoracic Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

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December 2019

Efficacy and Tolerability of Tremelimumab in Locally Advanced or Metastatic Urothelial Carcinoma Patients Who Have Failed First-Line Platinum-Based Chemotherapy.

Authors:
Padmanee Sharma Joohyuk Sohn Sang Joon Shin Do-Youn Oh Bhumsuk Keam Hyo Jin Lee Marco Gizzi Ewa Kalinka Filip Y F L de Vos Dario Ruscica Salvatore Ferro Feng Xiao Paul Baverel Cecil Chi-Keung Chen Kobby Asubonteng Nassim Morsli Luc Dirix

Clin Cancer Res 2020 01 4;26(1):61-70. Epub 2019 Dec 4.

St-Augustinus Ziekenhuis, Antwerp, Belgium.

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January 2020

Window-of-opportunity clinical trial of pembrolizumab in patients with recurrent glioblastoma reveals predominance of immune-suppressive macrophages.

Authors:
John de Groot Marta Penas-Prado Kristin Alfaro-Munoz Kathy Hunter Be Lian Pei Barbara O'Brien Shiao-Pei Weathers Monica Loghin Carlos Kamiya Matsouka W K Alfred Yung Jacob Mandel Jimin Wu Ying Yuan Shouhao Zhou Gregory N Fuller Jason Huse Ganesh Rao Jeffrey S Weinberg Sujit S Prabhu Ian E McCutcheon Frederick F Lang Sherise D Ferguson Raymond Sawaya Rivka Colen Shalini S Yadav Jorge Blando Luis Vence James Allison Padmanee Sharma Amy B Heimberger

Neuro Oncol 2020 04;22(4):539-549

Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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April 2020

Differences in Tumor Microenvironment Dictate T Helper Lineage Polarization and Response to Immune Checkpoint Therapy.

Authors:
Shiping Jiao Sumit K Subudhi Ana Aparicio Zhongqi Ge Baoxiang Guan Yuji Miura Padmanee Sharma

Cell 2019 Nov;179(5):1177-1190.e13

Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Graduate School of Biomedical Sciences, The University of Texas MD Anderson Cancer Center UTHealth, Houston, TX 77030, USA. Electronic address:

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November 2019

Phase II Trial of Ipilimumab with Stereotactic Radiation Therapy for Metastatic Disease: Outcomes, Toxicities, and Low-Dose Radiation-Related Abscopal Responses.

Authors:
James W Welsh Chad Tang Patricia de Groot Aung Naing Kenneth R Hess John V Heymach Vassiliki A Papadimitrakopoulou Taylor R Cushman Vivek Subbiah Joe Y Chang George R Simon Rishab Ramapriyan Hampartsoum B Barsoumian Hari Menon Maria Angelica Cortez Erminia Massarelli Quynh Nguyen Padmanee Sharma James P Allison Adi Diab Vivek Verma Uma Raju Sherif G Shaaban Ramona Dadu Maria E Cabanillas Kelvin Wang Clark Anderson Daniel R Gomez Stephen Hahn Ritsuko Komaki David S Hong

Cancer Immunol Res 2019 12 28;7(12):1903-1909. Epub 2019 Oct 28.

Department of Investigational Cancer Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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December 2019

Autoimmune antibodies correlate with immune checkpoint therapy-induced toxicities.

Authors:
Salahaldin A Tahir Jianjun Gao Yuji Miura Jorge Blando Rebecca S S Tidwell Hao Zhao Sumit K Subudhi Hussein Tawbi Emily Keung Jennifer Wargo James P Allison Padmanee Sharma

Proc Natl Acad Sci U S A 2019 10 14;116(44):22246-22251. Epub 2019 Oct 14.

Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030;

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October 2019

Nivolumab for the Treatment of Patients with Metastatic Non-Clear Cell Renal Cell Carcinoma (nccRCC): A Single-Institutional Experience and Literature Meta-Analysis.

Authors:
Jad Chahoud Pavlos Msaouel Matthew T Campbell Tharakeswara Bathala Lianchun Xiao Jianjun Gao Amado J Zurita Amishi Yogesh Shah Eric Jonasch Padmanee Sharma Nizar M Tannir

Oncologist 2019 Sep 9. Epub 2019 Sep 9.

The University of Texas MD Anderson Cancer Center, Houston, Texas, USA

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September 2019

Blockade of CTLA-4 and PD-1 Enhances Adoptive T-cell Therapy Efficacy in an ICOS-Mediated Manner.

Authors:
Lewis Zhichang Shi Sangeeta Goswami Tihui Fu Baoxiang Guan Jianfeng Chen Liangwen Xiong Jan Zhang Derek Ng Tang Xuejun Zhang Luis Vence Jorge Blando James P Allison Renata Collazo Jianjun Gao Padmanee Sharma

Cancer Immunol Res 2019 Nov 29;7(11):1803-1812. Epub 2019 Aug 29.

Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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November 2019

Idarubicin, cytarabine, and nivolumab in patients with newly diagnosed acute myeloid leukaemia or high-risk myelodysplastic syndrome: a single-arm, phase 2 study.

Authors:
Farhad Ravandi Rita Assi Naval Daver Christopher B Benton Tapan Kadia Philip A Thompson Gautam Borthakur Yesid Alvarado Elias J Jabbour Marina Konopleva Koichi Takahashi Steven Kornblau Courtney D DiNardo Zeev Estrov Wilmer Flores Sreyashi Basu James Allison Padmanee Sharma Sherry Pierce Allison Pike Jorge E Cortes Guillermo Garcia-Manero Hagop M Kantarjian

Lancet Haematol 2019 Sep 7;6(9):e480-e488. Epub 2019 Aug 7.

Department of Leukaemia, the University of Texas MD Anderson Cancer Center, Houston, TX, USA.

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September 2019

Characterization and Comparison of GITR Expression in Solid Tumors.

Authors:
Luis Vence Samantha L Bucktrout Irina Fernandez Curbelo Jorge Blando Bevin M Smith Ashley E Mahne John C Lin Terrence Park Edward Pascua Tao Sai Javier Chaparro-Riggers Sumit K Subudhi Jorge B Scutti Maria G Higa Hao Zhao Shalini S Yadav Anirban Maitra Ignacio I Wistuba James P Allison Padmanee Sharma

Clin Cancer Res 2019 11 29;25(21):6501-6510. Epub 2019 Jul 29.

The Immunotherapy Platform, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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November 2019

Immunologic Correlates of Pathologic Complete Response to Preoperative Immunotherapy in Hepatocellular Carcinoma.

Authors:
Ahmed Omar Kaseb Luis Vence Jorge Blando Shalini S Yadav Naruhiko Ikoma Roberto Carmagnani Pestana Jean Nicolas Vauthey James P Allison Padmanee Sharma

Cancer Immunol Res 2019 Sep 9;7(9):1390-1395. Epub 2019 Jul 9.

Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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September 2019

Fibroblast Growth Factor Receptor 3 Alterations and Response to PD-1/PD-L1 Blockade in Patients with Metastatic Urothelial Cancer.

Authors:
Li Wang Yixuan Gong Abdel Saci Peter M Szabo Alberto Martini Andrea Necchi Arlene Siefker-Radtke Sumanta Pal Elizabeth R Plimack John P Sfakianos Nina Bhardwaj Amir Horowitz Adam M Farkas David Mulholland Bruce S Fischer William K Oh Padmanee Sharma Jun Zhu Matthew D Galsky

Eur Urol 2019 11 1;76(5):599-603. Epub 2019 Jul 1.

Department of Medicine, Division of Hematology Oncology, Icahn School of Medicine at Mount Sinai, Tisch Cancer Institute, New York, NY, USA. Electronic address:

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November 2019

Nivolumab in patients with unresectable locally advanced or metastatic urothelial carcinoma: CheckMate 275 2-year global and Japanese patient population analyses.

Authors:
Chikara Ohyama Takahiro Kojima Tsunenori Kondo Yoshio Naya Takamitsu Inoue Yoshihiko Tomita Masatoshi Eto Shinichi Hisasue Hirotsugu Uemura Wataru Obara Eiji Kikuchi Padmanee Sharma Matthew D Galsky Arlene Siefker-Radtke Gary Grossfeld Sandra Collette Kyna Gooden Go Kimura

Int J Clin Oncol 2019 Sep 19;24(9):1089-1098. Epub 2019 Jun 19.

Department of Urology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo, 113-8603, Japan.

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September 2019