Padmanee Sharma

Padmanee Sharma

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Padmanee Sharma

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Dissecting the mechanisms of immune checkpoint therapy.

Authors:
Padmanee Sharma James P Allison

Nat Rev Immunol 2020 Feb;20(2):75-76

Department of Immunology, The University of Texas, MD Anderson Cancer Center, Houston, TX, USA.

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http://dx.doi.org/10.1038/s41577-020-0275-8DOI Listing
February 2020

Efficacy and Tolerability of Tremelimumab in Locally Advanced or Metastatic Urothelial Carcinoma Patients Who Have Failed First-Line Platinum-Based Chemotherapy.

Authors:
Padmanee Sharma Joohyuk Sohn Sang Joon Shin Do-Youn Oh Bhumsuk Keam Hyo Jin Lee Marco Gizzi Ewa Kalinka Filip Y F L de Vos Dario Ruscica Salvatore Ferro Feng Xiao Paul Baverel Cecil Chi-Keung Chen Kobby Asubonteng Nassim Morsli Luc Dirix

Clin Cancer Res 2020 Jan 4;26(1):61-70. Epub 2019 Dec 4.

St-Augustinus Ziekenhuis, Antwerp, Belgium.

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http://dx.doi.org/10.1158/1078-0432.CCR-19-1635DOI Listing
January 2020

Immune profiling of human tumors identifies CD73 as a combinatorial target in glioblastoma.

Authors:
Sangeeta Goswami Thomas Walle Andrew E Cornish Sreyashi Basu Swetha Anandhan Irina Fernandez Luis Vence Jorge Blando Hao Zhao Shalini Singh Yadav Martina Ott Ling Y Kong Amy B Heimberger John de Groot Boris Sepesi Michael Overman Scott Kopetz James P Allison Dana Pe'er Padmanee Sharma

Nat Med 2020 Jan 23;26(1):39-46. Epub 2019 Dec 23.

Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

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http://dx.doi.org/10.1038/s41591-019-0694-xDOI Listing
January 2020

B cells and tertiary lymphoid structures promote immunotherapy response.

Authors:
Beth A Helmink Sangeetha M Reddy Jianjun Gao Shaojun Zhang Rafet Basar Rohit Thakur Keren Yizhak Moshe Sade-Feldman Jorge Blando Guangchun Han Vancheswaran Gopalakrishnan Yuanxin Xi Hao Zhao Rodabe N Amaria Hussein A Tawbi Alex P Cogdill Wenbin Liu Valerie S LeBleu Fernanda G Kugeratski Sapna Patel Michael A Davies Patrick Hwu Jeffrey E Lee Jeffrey E Gershenwald Anthony Lucci Reetakshi Arora Scott Woodman Emily Z Keung Pierre-Olivier Gaudreau Alexandre Reuben Christine N Spencer Elizabeth M Burton Lauren E Haydu Alexander J Lazar Roberta Zapassodi Courtney W Hudgens Deborah A Ledesma SuFey Ong Michael Bailey Sarah Warren Disha Rao Oscar Krijgsman Elisa A Rozeman Daniel Peeper Christian U Blank Ton N Schumacher Lisa H Butterfield Monika A Zelazowska Kevin M McBride Raghu Kalluri James Allison Florent Petitprez Wolf Herman Fridman Catherine Sautès-Fridman Nir Hacohen Katayoun Rezvani Padmanee Sharma Michael T Tetzlaff Linghua Wang Jennifer A Wargo

Nature 2020 01 15;577(7791):549-555. Epub 2020 Jan 15.

Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

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http://dx.doi.org/10.1038/s41586-019-1922-8DOI Listing
January 2020

Comprehensive T cell repertoire characterization of non-small cell lung cancer.

Authors:
Alexandre Reuben Jiexin Zhang Shin-Heng Chiou Rachel M Gittelman Jun Li Won-Chul Lee Junya Fujimoto Carmen Behrens Xiaoke Liu Feng Wang Kelly Quek Chunlin Wang Farrah Kheradmand Runzhe Chen Chi-Wan Chow Heather Lin Chantale Bernatchez Ali Jalali Xin Hu Chang-Jiun Wu Agda Karina Eterovic Edwin Roger Parra Erik Yusko Ryan Emerson Sharon Benzeno Marissa Vignali Xifeng Wu Yuanqing Ye Latasha D Little Curtis Gumbs Xizeng Mao Xingzhi Song Samantha Tippen Rebecca L Thornton Tina Cascone Alexandra Snyder Jennifer A Wargo Roy Herbst Stephen Swisher Humam Kadara Cesar Moran Neda Kalhor Jianhua Zhang Paul Scheet Ara A Vaporciyan Boris Sepesi Don L Gibbons Harlan Robins Patrick Hwu John V Heymach Padmanee Sharma James P Allison Veera Baladandayuthapani Jack J Lee Mark M Davis Ignacio I Wistuba P Andrew Futreal Jianjun Zhang

Nat Commun 2020 Jan 30;11(1):603. Epub 2020 Jan 30.

Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe, Houston, TX, 77030, USA.

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http://dx.doi.org/10.1038/s41467-019-14273-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6992630PMC
January 2020

Phase II Trial of Ipilimumab with Stereotactic Radiation Therapy for Metastatic Disease: Outcomes, Toxicities, and Low-Dose Radiation-Related Abscopal Responses.

Authors:
James W Welsh Chad Tang Patricia de Groot Aung Naing Kenneth R Hess John V Heymach Vassiliki A Papadimitrakopoulou Taylor R Cushman Vivek Subbiah Joe Y Chang George R Simon Rishab Ramapriyan Hampartsoum B Barsoumian Hari Menon Maria Angelica Cortez Erminia Massarelli Quynh Nguyen Padmanee Sharma James P Allison Adi Diab Vivek Verma Uma Raju Sherif G Shaaban Ramona Dadu Maria E Cabanillas Kelvin Wang Clark Anderson Daniel R Gomez Stephen Hahn Ritsuko Komaki David S Hong

Cancer Immunol Res 2019 Dec 28;7(12):1903-1909. Epub 2019 Oct 28.

Department of Investigational Cancer Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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http://dx.doi.org/10.1158/2326-6066.CIR-18-0793DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6891218PMC
December 2019

High OX-40 expression in the tumor immune infiltrate is a favorable prognostic factor of overall survival in non-small cell lung cancer.

Authors:
Erminia Massarelli Vincent K Lam Edwin R Parra Jaime Rodriguez-Canales Carmen Behrens Lixia Diao Jing Wang Jorge Blando Lauren A Byers Niranjan Yanamandra Sara Brett Peter Morley Padmanee Sharma James Allison Ignacio I Wistuba John V Heymach

J Immunother Cancer 2019 Dec 16;7(1):351. Epub 2019 Dec 16.

Department of Thoracic Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

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http://dx.doi.org/10.1186/s40425-019-0827-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6915970PMC
December 2019

Fibroblast Growth Factor Receptor 3 Alterations and Response to PD-1/PD-L1 Blockade in Patients with Metastatic Urothelial Cancer.

Authors:
Li Wang Yixuan Gong Abdel Saci Peter M Szabo Alberto Martini Andrea Necchi Arlene Siefker-Radtke Sumanta Pal Elizabeth R Plimack John P Sfakianos Nina Bhardwaj Amir Horowitz Adam M Farkas David Mulholland Bruce S Fischer William K Oh Padmanee Sharma Jun Zhu Matthew D Galsky

Eur Urol 2019 Nov 1;76(5):599-603. Epub 2019 Jul 1.

Department of Medicine, Division of Hematology Oncology, Icahn School of Medicine at Mount Sinai, Tisch Cancer Institute, New York, NY, USA. Electronic address:

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http://dx.doi.org/10.1016/j.eururo.2019.06.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6801024PMC
November 2019

Characterization and Comparison of GITR Expression in Solid Tumors.

Authors:
Luis Vence Samantha L Bucktrout Irina Fernandez Curbelo Jorge Blando Bevin M Smith Ashley E Mahne John C Lin Terrence Park Edward Pascua Tao Sai Javier Chaparro-Riggers Sumit K Subudhi Jorge B Scutti Maria G Higa Hao Zhao Shalini S Yadav Anirban Maitra Ignacio I Wistuba James P Allison Padmanee Sharma

Clin Cancer Res 2019 Nov 29;25(21):6501-6510. Epub 2019 Jul 29.

The Immunotherapy Platform, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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http://dx.doi.org/10.1158/1078-0432.CCR-19-0289DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6825542PMC
November 2019

Blockade of CTLA-4 and PD-1 Enhances Adoptive T-cell Therapy Efficacy in an ICOS-Mediated Manner.

Authors:
Lewis Zhichang Shi Sangeeta Goswami Tihui Fu Baoxiang Guan Jianfeng Chen Liangwen Xiong Jan Zhang Derek Ng Tang Xuejun Zhang Luis Vence Jorge Blando James P Allison Renata Collazo Jianjun Gao Padmanee Sharma

Cancer Immunol Res 2019 Nov 29;7(11):1803-1812. Epub 2019 Aug 29.

Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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http://dx.doi.org/10.1158/2326-6066.CIR-18-0873DOI Listing
November 2019

Differences in Tumor Microenvironment Dictate T Helper Lineage Polarization and Response to Immune Checkpoint Therapy.

Authors:
Shiping Jiao Sumit K Subudhi Ana Aparicio Zhongqi Ge Baoxiang Guan Yuji Miura Padmanee Sharma

Cell 2019 Nov;179(5):1177-1190.e13

Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Graduate School of Biomedical Sciences, The University of Texas MD Anderson Cancer Center UTHealth, Houston, TX 77030, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2019.10.029DOI Listing
November 2019

Window-of-opportunity clinical trial of pembrolizumab in patients with recurrent glioblastoma reveals predominance of immune-suppressive macrophages.

Authors:
J de Groot M Penas-Prado K D Alfaro-Munoz K Hunter B Pei B O'brien S-P Weathers M Loghin Carlos Kamiya Matsouka W K Alfred Yung Jacob Mandel Jimin Wu Ying Yuan Shouhao Zhou Gregory N Fuller Jason Huse Ganesh Rao Jeffrey S Weinberg Sujit S Prabhu Ian E McCutcheon Frederick F Lang Sherise D Ferguson Raymond Sawaya Rivka Colen Shalini S Yadav Jorge Blando Luis Vence James Allison Padmanee Sharma Amy B Heimberger

Neuro Oncol 2019 Nov 22. Epub 2019 Nov 22.

Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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http://dx.doi.org/10.1093/neuonc/noz185DOI Listing
November 2019

Autoimmune antibodies correlate with immune checkpoint therapy-induced toxicities.

Authors:
Salahaldin A Tahir Jianjun Gao Yuji Miura Jorge Blando Rebecca S S Tidwell Hao Zhao Sumit K Subudhi Hussein Tawbi Emily Keung Jennifer Wargo James P Allison Padmanee Sharma

Proc Natl Acad Sci U S A 2019 Oct 14;116(44):22246-22251. Epub 2019 Oct 14.

Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030;

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http://dx.doi.org/10.1073/pnas.1908079116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6825284PMC
October 2019

Nivolumab in patients with unresectable locally advanced or metastatic urothelial carcinoma: CheckMate 275 2-year global and Japanese patient population analyses.

Authors:
Chikara Ohyama Takahiro Kojima Tsunenori Kondo Yoshio Naya Takamitsu Inoue Yoshihiko Tomita Masatoshi Eto Shinichi Hisasue Hirotsugu Uemura Wataru Obara Eiji Kikuchi Padmanee Sharma Matthew D Galsky Arlene Siefker-Radtke Gary Grossfeld Sandra Collette Kyna Gooden Go Kimura

Int J Clin Oncol 2019 Sep 19;24(9):1089-1098. Epub 2019 Jun 19.

Department of Urology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo, 113-8603, Japan.

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http://dx.doi.org/10.1007/s10147-019-01450-wDOI Listing
September 2019

Immunologic Correlates of Pathologic Complete Response to Preoperative Immunotherapy in Hepatocellular Carcinoma.

Authors:
Ahmed Omar Kaseb Luis Vence Jorge Blando Shalini S Yadav Naruhiko Ikoma Roberto Carmagnani Pestana Jean Nicolas Vauthey James P Allison Padmanee Sharma

Cancer Immunol Res 2019 Sep 9;7(9):1390-1395. Epub 2019 Jul 9.

Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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http://dx.doi.org/10.1158/2326-6066.CIR-18-0605DOI Listing
September 2019

Idarubicin, cytarabine, and nivolumab in patients with newly diagnosed acute myeloid leukaemia or high-risk myelodysplastic syndrome: a single-arm, phase 2 study.

Authors:
Farhad Ravandi Rita Assi Naval Daver Christopher B Benton Tapan Kadia Philip A Thompson Gautam Borthakur Yesid Alvarado Elias J Jabbour Marina Konopleva Koichi Takahashi Steven Kornblau Courtney D DiNardo Zeev Estrov Wilmer Flores Sreyashi Basu James Allison Padmanee Sharma Sherry Pierce Allison Pike Jorge E Cortes Guillermo Garcia-Manero Hagop M Kantarjian

Lancet Haematol 2019 Sep 7;6(9):e480-e488. Epub 2019 Aug 7.

Department of Leukaemia, the University of Texas MD Anderson Cancer Center, Houston, TX, USA.

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http://dx.doi.org/10.1016/S2352-3026(19)30114-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6778960PMC
September 2019

Nivolumab for the Treatment of Patients with Metastatic Non-Clear Cell Renal Cell Carcinoma (nccRCC): A Single-Institutional Experience and Literature Meta-Analysis.

Authors:
Jad Chahoud Pavlos Msaouel Matthew T Campbell Tharakeswara Bathala Lianchun Xiao Jianjun Gao Amado J Zurita Amishi Yogesh Shah Eric Jonasch Padmanee Sharma Nizar M Tannir

Oncologist 2019 Sep 9. Epub 2019 Sep 9.

The University of Texas MD Anderson Cancer Center, Houston, Texas, USA

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http://dx.doi.org/10.1634/theoncologist.2019-0372DOI Listing
September 2019

Nivolumab Alone and With Ipilimumab in Previously Treated Metastatic Urothelial Carcinoma: CheckMate 032 Nivolumab 1 mg/kg Plus Ipilimumab 3 mg/kg Expansion Cohort Results.

Authors:
Padmanee Sharma Arlene Siefker-Radtke Filippo de Braud Umberto Basso Emiliano Calvo Petri Bono Michael A Morse Paolo A Ascierto Jose Lopez-Martin Peter Brossart Kristoffer Rohrberg Begoña Mellado Bruce S Fischer Stephanie Meadows-Shropshire Abdel Saci Margaret K Callahan Jonathan Rosenberg

J Clin Oncol 2019 Jul 17;37(19):1608-1616. Epub 2019 May 17.

14 Memorial Sloan Kettering Cancer Center, New York, NY.

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http://dx.doi.org/10.1200/JCO.19.00538DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6879315PMC
July 2019

Anti-CTLA-4 Immunotherapy Does Not Deplete FOXP3 Regulatory T Cells (Tregs) in Human Cancers-Response.

Authors:
Anu Sharma Sumit K Subudhi Jorge Blando Luis Vence Jennifer Wargo James P Allison Antoni Ribas Padmanee Sharma

Clin Cancer Res 2019 06;25(11):3469-3470

Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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http://clincancerres.aacrjournals.org/lookup/doi/10.1158/107
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http://dx.doi.org/10.1158/1078-0432.CCR-19-0402DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6662573PMC
June 2019

The distribution of T-cell subsets and the expression of immune checkpoint receptors and ligands in patients with newly diagnosed and relapsed acute myeloid leukemia.

Authors:
Patrick Williams Sreyashi Basu Guillermo Garcia-Manero Christopher S Hourigan Karolyn A Oetjen Jorge E Cortes Farhad Ravandi Elias J Jabbour Zainab Al-Hamal Marina Konopleva Jing Ning Lianchun Xiao Juliana Hidalgo Lopez Steve M Kornblau Michael Andreeff Wilmer Flores Carlos Bueso-Ramos Jorge Blando Pallavi Galera Katherine R Calvo Gheath Al-Atrash James P Allison Hagop M Kantarjian Padmanee Sharma Naval G Daver

Cancer 2019 05 30;125(9):1470-1481. Epub 2018 Nov 30.

Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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http://doi.wiley.com/10.1002/cncr.31896
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http://dx.doi.org/10.1002/cncr.31896DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467779PMC
May 2019

Update on Immunotherapy in AML and MDS: Monoclonal Antibodies and Checkpoint Inhibitors Paving the Road for Clinical Practice.

Authors:
Lucia Masarova Hagop Kantarjian Farhad Ravandi Padmanee Sharma Guillermo Garcia-Manero Naval Daver

Adv Exp Med Biol 2018;995:97-116

Department of Leukemia, MD Anderson Cancer Center, Houston, TX, USA.

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http://link.springer.com/10.1007/978-3-030-02505-2_4
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http://dx.doi.org/10.1007/978-3-030-02505-2_4DOI Listing
May 2019

Negative Co-stimulation Constrains T Cell Differentiation by Imposing Boundaries on Possible Cell States.

Authors:
Spencer C Wei Roshan Sharma Nana-Ama A S Anang Jacob H Levine Yang Zhao James J Mancuso Manu Setty Padmanee Sharma Jing Wang Dana Pe'er James P Allison

Immunity 2019 04 26;50(4):1084-1098.e10. Epub 2019 Mar 26.

Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Parker Institute for Cancer Immunotherapy, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10747613193009
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http://dx.doi.org/10.1016/j.immuni.2019.03.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6664799PMC
April 2019

Efficacy, Safety, and Biomarkers of Response to Azacitidine and Nivolumab in Relapsed/Refractory Acute Myeloid Leukemia: A Nonrandomized, Open-Label, Phase II Study.

Authors:
Naval Daver Guillermo Garcia-Manero Sreyashi Basu Prajwal C Boddu Mansour Alfayez Jorge E Cortes Marina Konopleva Farhad Ravandi-Kashani Elias Jabbour Tapan Kadia Graciela M Nogueras-Gonzalez Jing Ning Naveen Pemmaraju Courtney D DiNardo Michael Andreeff Sherry A Pierce Tauna Gordon Steven M Kornblau Wilmer Flores Zainab Alhamal Carlos Bueso-Ramos Jeffrey L Jorgensen Keyur P Patel Jorge Blando James P Allison Padmanee Sharma Hagop Kantarjian

Cancer Discov 2019 03 8;9(3):370-383. Epub 2018 Nov 8.

Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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http://cancerdiscovery.aacrjournals.org/lookup/doi/10.1158/2
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http://dx.doi.org/10.1158/2159-8290.CD-18-0774DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397669PMC
March 2019

Anti-CTLA-4 Immunotherapy Does Not Deplete FOXP3 Regulatory T Cells (Tregs) in Human Cancers.

Authors:
Anu Sharma Sumit K Subudhi Jorge Blando Jorge Scutti Luis Vence Jennifer Wargo James P Allison Antoni Ribas Padmanee Sharma

Clin Cancer Res 2019 02 27;25(4):1233-1238. Epub 2018 Jul 27.

Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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http://clincancerres.aacrjournals.org/lookup/doi/10.1158/107
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http://dx.doi.org/10.1158/1078-0432.CCR-18-0762DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348141PMC
February 2019

Author Correction: Fecal microbiota transplantation for refractory immune checkpoint inhibitor-associated colitis.

Authors:
Yinghong Wang Diana H Wiesnoski Beth A Helmink Vancheswaran Gopalakrishnan Kati Choi Hebert L DuPont Zhi-Dong Jiang Hamzah Abu-Sbeih Christopher A Sanchez Chia-Chi Chang Edwin R Parra Alejandro Francisco-Cruz Gottumukkala S Raju John R Stroehlein Matthew T Campbell Jianjun Gao Sumit K Subudhi Dipen M Maru Jorge M Blando Alexander J Lazar James P Allison Padmanee Sharma Michael T Tetzlaff Jennifer A Wargo Robert R Jenq

Nat Med 2019 Jan;25(1):188

Department of Genomic Medicine, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

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http://dx.doi.org/10.1038/s41591-018-0305-2DOI Listing
January 2019

Comparison of immune infiltrates in melanoma and pancreatic cancer highlights VISTA as a potential target in pancreatic cancer.

Authors:
Jorge Blando Anu Sharma Maria Gisela Higa Hao Zhao Luis Vence Shalini S Yadav Jiseong Kim Alejandro M Sepulveda Michael Sharp Anirban Maitra Jennifer Wargo Michael Tetzlaff Russell Broaddus Matthew H G Katz Gauri R Varadhachary Michael Overman Huamin Wang Cassian Yee Chantale Bernatchez Christine Iacobuzio-Donahue Sreyashi Basu James P Allison Padmanee Sharma

Proc Natl Acad Sci U S A 2019 01 11;116(5):1692-1697. Epub 2019 Jan 11.

The Immunotherapy Platform, The University of Texas MD Anderson Cancer Center, Houston, TX 77054;

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http://dx.doi.org/10.1073/pnas.1811067116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358697PMC
January 2019

Author Correction: Neoadjuvant immune checkpoint blockade in high-risk resectable melanoma.

Authors:
Rodabe N Amaria Sangeetha M Reddy Hussein A Tawbi Michael A Davies Merrick I Ross Isabella C Glitza Janice N Cormier Carol Lewis Wen-Jen Hwu Ehab Hanna Adi Diab Michael K Wong Richard Royal Neil Gross Randal Weber Stephen Y Lai Richard Ehlers Jorge Blando Denái R Milton Scott Woodman Robin Kageyama Daniel K Wells Patrick Hwu Sapna P Patel Anthony Lucci Amy Hessel Jeffrey E Lee Jeffrey Gershenwald Lauren Simpson Elizabeth M Burton Liberty Posada Lauren Haydu Linghua Wang Shaojun Zhang Alexander J Lazar Courtney W Hudgens Vancheswaran Gopalakrishnan Alexandre Reuben Miles C Andrews Christine N Spencer Victor Prieto Padmanee Sharma James Allison Michael T Tetzlaff Jennifer A Wargo

Nat Med 2018 Dec;24(12):1941

Department of Surgical Oncology, MD Anderson Cancer Center, Houston, TX, USA.

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http://www.nature.com/articles/s41591-018-0251-z
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http://dx.doi.org/10.1038/s41591-018-0251-zDOI Listing
December 2018

Publisher Correction: Neoadjuvant immune checkpoint blockade in high-risk resectable melanoma.

Authors:
Rodabe N Amaria Sangeetha M Reddy Hussein A Tawbi Michael A Davies Merrick I Ross Isabella C Glitza Janice N Cormier Carol Lewis Wen-Jen Hwu Ehab Hanna Adi Diab Michael K Wong Richard Royal Neil Gross Randal Weber Stephen Y Lai Richard Ehlers Jorge Blando Denái R Milton Scott Woodman Robin Kageyama Daniel K Wells Patrick Hwu Sapna P Patel Anthony Lucci Amy Hessel Jeffrey E Lee Jeffrey Gershenwald Lauren Simpson Elizabeth M Burton Liberty Posada Lauren Haydu Linghua Wang Shaojun Zhang Alexander J Lazar Courtney W Hudgens Vancheswaran Gopalakrishnan Alexandre Reuben Miles C Andrews Christine N Spencer Victor Prieto Padmanee Sharma James Allison Michael T Tetzlaff Jennifer A Wargo

Nat Med 2018 Dec;24(12):1942

Department of Surgical Oncology, MD Anderson Cancer Center, Houston, TX, USA.

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http://www.nature.com/articles/s41591-018-0252-y
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http://dx.doi.org/10.1038/s41591-018-0252-yDOI Listing
December 2018

Fecal microbiota transplantation for refractory immune checkpoint inhibitor-associated colitis.

Authors:
Yinghong Wang Diana H Wiesnoski Beth A Helmink Vancheswaran Gopalakrishnan Kati Choi Hebert L DuPont Zhi-Dong Jiang Hamzah Abu-Sbeih Christopher A Sanchez Chia-Chi Chang Edwin R Parra Alejandro Francisco-Cruz Gottumukkala S Raju John R Stroehlein Matthew T Campbell Jianjun Gao Sumit K Subudhi Dipen M Maru Jorge M Blando Alexander J Lazar James P Allison Padmanee Sharma Michael T Tetzlaff Jennifer A Wargo Robert R Jenq

Nat Med 2018 12 12;24(12):1804-1808. Epub 2018 Nov 12.

Department of Genomic Medicine, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

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http://www.nature.com/articles/s41591-018-0238-9
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http://dx.doi.org/10.1038/s41591-018-0238-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322556PMC
December 2018

Neoadjuvant immune checkpoint blockade in high-risk resectable melanoma.

Authors:
Rodabe N Amaria Sangeetha M Reddy Hussein A Tawbi Michael A Davies Merrick I Ross Isabella C Glitza Janice N Cormier Carol Lewis Wen-Jen Hwu Ehab Hanna Adi Diab Michael K Wong Richard Royal Neil Gross Randal Weber Stephen Y Lai Richard Ehlers Jorge Blando Denái R Milton Scott Woodman Robin Kageyama Daniel K Wells Patrick Hwu Sapna P Patel Anthony Lucci Amy Hessel Jeffrey E Lee Jeffrey Gershenwald Lauren Simpson Elizabeth M Burton Liberty Posada Lauren Haydu Linghua Wang Shaojun Zhang Alexander J Lazar Courtney W Hudgens Vancheswaran Gopalakrishnan Alexandre Reuben Miles C Andrews Christine N Spencer Victor Prieto Padmanee Sharma James Allison Michael T Tetzlaff Jennifer A Wargo

Nat Med 2018 11 8;24(11):1649-1654. Epub 2018 Oct 8.

Department of Surgical Oncology, MD Anderson Cancer Center, Houston, TX, USA.

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http://www.nature.com/articles/s41591-018-0197-1
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http://dx.doi.org/10.1038/s41591-018-0197-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6481682PMC
November 2018

CheckMate-032 Study: Efficacy and Safety of Nivolumab and Nivolumab Plus Ipilimumab in Patients With Metastatic Esophagogastric Cancer.

Authors:
Yelena Y Janjigian Johanna Bendell Emiliano Calvo Joseph W Kim Paolo A Ascierto Padmanee Sharma Patrick A Ott Katriina Peltola Dirk Jaeger Jeffry Evans Filippo de Braud Ian Chau Christopher T Harbison Cecile Dorange Marina Tschaika Dung T Le

J Clin Oncol 2018 10 15;36(28):2836-2844. Epub 2018 Aug 15.

Yelena Y. Janjigian, Memorial Sloan Kettering Cancer Center and Weill Cornell Medical College, New York, NY; Johanna Bendell, Sarah Cannon Research Institute, Tennessee Oncology, Nashville, TN; Emiliano Calvo, START Madrid, Centro Integral Oncológico Clara Campal, Madrid, Spain; Joseph W. Kim, Yale Cancer Center, New Haven, CT; Paolo A. Ascierto, Istituto Nazionale Tumori IRCCS Fondazione Pascale, Naples; Filippo de Braud, Fondazione IRCCS Istituto Nazionale dei Tumori and University of Milan, Milan, Italy; Padmanee Sharma, The University of Texas MD Anderson Cancer Center, Houston, TX; Patrick A. Ott, Dana-Farber Cancer Institute, Boston, MA; Katriina Peltola, Docrates Cancer Center, Helsinki, Finland; Dirk Jaeger, University Hospital Heidelberg, Heidelberg, Germany; Jeffry Evans, University of Glasgow, Glasgow; Ian Chau, Royal Marsden Hospital, London and Surrey, United Kingdom; Christopher T. Harbison, Cecile Dorange, Marina Tschaika, Bristol-Myers Squibb, Princeton, NJ; and Dung T. Le, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD.

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http://dx.doi.org/10.1200/JCO.2017.76.6212DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161834PMC
October 2018

Radiomics to predict immunotherapy-induced pneumonitis: proof of concept.

Authors:
Rivka R Colen Takeo Fujii Mehmet Asim Bilen Aikaterini Kotrotsou Srishti Abrol Kenneth R Hess Joud Hajjar Maria E Suarez-Almazor Anas Alshawa David S Hong Dunia Giniebra-Camejo Bettzy Stephen Vivek Subbiah Ajay Sheshadri Tito Mendoza Siqing Fu Padmanee Sharma Funda Meric-Bernstam Aung Naing

Invest New Drugs 2018 08 27;36(4):601-607. Epub 2017 Oct 27.

Department of Investigational Cancer Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030-4004, USA.

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http://dx.doi.org/10.1007/s10637-017-0524-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5924418PMC
August 2018

Incidence of immune-related adverse events and its association with treatment outcomes: the MD Anderson Cancer Center experience.

Authors:
Takeo Fujii Rivka R Colen Mehmet Asim Bilen Kenneth R Hess Joud Hajjar Maria E Suarez-Almazor Anas Alshawa David S Hong Apostolia Tsimberidou Filip Janku Jing Gong Bettzy Stephen Vivek Subbiah Sarina A Piha-Paul Siqing Fu Padmanee Sharma Tito Mendoza Anisha Patel Selvi Thirumurthi Ajay Sheshadri Funda Meric-Bernstam Aung Naing

Invest New Drugs 2018 08 21;36(4):638-646. Epub 2017 Nov 21.

Department of Investigational Cancer Therapeutics, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX, 77030, USA.

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http://dx.doi.org/10.1007/s10637-017-0534-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5962379PMC
August 2018

Modulation of EZH2 expression in T cells improves efficacy of anti-CTLA-4 therapy.

Authors:
Sangeeta Goswami Irina Apostolou Jan Zhang Jill Skepner Swetha Anandhan Xuejun Zhang Liangwen Xiong Patrick Trojer Ana Aparicio Sumit K Subudhi James P Allison Hao Zhao Padmanee Sharma

J Clin Invest 2018 08 30;128(9):3813-3818. Epub 2018 Jul 30.

Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

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https://www.jci.org/articles/view/99760
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http://dx.doi.org/10.1172/JCI99760DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6118570PMC
August 2018

EMT- and stroma-related gene expression and resistance to PD-1 blockade in urothelial cancer.

Authors:
Li Wang Abdel Saci Peter M Szabo Scott D Chasalow Mireia Castillo-Martin Josep Domingo-Domenech Arlene Siefker-Radtke Padmanee Sharma John P Sfakianos Yixuan Gong Ana Dominguez-Andres William K Oh David Mulholland Alex Azrilevich Liangyuan Hu Carlos Cordon-Cardo Hélène Salmon Nina Bhardwaj Jun Zhu Matthew D Galsky

Nat Commun 2018 08 29;9(1):3503. Epub 2018 Aug 29.

Department of Medicine, Division of Hematology Oncology, Icahn School of Medicine at Mount Sinai, Tisch Cancer Institute, New York, NY, 10029, USA.

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http://www.nature.com/articles/s41467-018-05992-x
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6115401PMC
August 2018

Phase I clinical trial of combination imatinib and ipilimumab in patients with advanced malignancies.

Authors:
Matthew J Reilley Ann Bailey Vivek Subbiah Filip Janku Aung Naing Gerald Falchook Daniel Karp Sarina Piha-Paul Apostolia Tsimberidou Siqing Fu JoAnn Lim Stacie Bean Allison Bass Sandra Montez Luis Vence Padmanee Sharma James Allison Funda Meric-Bernstam David S Hong

J Immunother Cancer 2017 18;5:35. Epub 2017 Apr 18.

Department of Investigational Cancer Therapeutics, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030 USA.

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http://dx.doi.org/10.1186/s40425-017-0238-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5394629PMC
June 2018

Hypomethylating agents in combination with immune checkpoint inhibitors in acute myeloid leukemia and myelodysplastic syndromes.

Authors:
Naval Daver Prajwal Boddu Guillermo Garcia-Manero Shalini Singh Yadav Padmanee Sharma James Allison Hagop Kantarjian

Leukemia 2018 05 22;32(5):1094-1105. Epub 2018 Feb 22.

Department of Leukemia, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA.

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http://www.nature.com/articles/s41375-018-0070-8
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6916728PMC
May 2018

The emerging role of immune checkpoint based approaches in AML and MDS.

Authors:
Prajwal Boddu Hagop Kantarjian Guillermo Garcia-Manero James Allison Padmanee Sharma Naval Daver

Leuk Lymphoma 2018 04 6;59(4):790-802. Epub 2017 Jul 6.

a Department of Leukemia , The University of Texas M. D. Anderson Cancer Center , Houston , TX , USA.

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https://www.tandfonline.com/doi/full/10.1080/10428194.2017.1
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http://dx.doi.org/10.1080/10428194.2017.1344905DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5872841PMC
April 2018

Erratum to "CheckMate 025 Randomized Phase 3 Study: Outcomes by Key Baseline Factors and Prior Therapy for Nivolumab Versus Everolimus in Advanced Renal Cell Carcinoma" [Eur Urol 2017;72:962-71].

Authors:
Bernard Escudier Padmanee Sharma David F McDermott Saby George Hans J Hammers Sandhya Srinivas Scott S Tykodi Jeffrey A Sosman Giuseppe Procopio Elizabeth R Plimack Daniel Castellano Howard Gurney Frede Donskov Katriina Peltola John Wagstaff Thomas C Gauler Takeshi Ueda Huanyu Zhao Ian M Waxman Robert J Motzer

Eur Urol 2018 04 3;73(4):e116-e118. Epub 2018 Jan 3.

Memorial Sloan Kettering Cancer Center, New York, NY, USA.

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http://dx.doi.org/10.1016/j.eururo.2017.12.016DOI Listing
April 2018

Cancer vaccine formulation dictates synergy with CTLA-4 and PD-L1 checkpoint blockade therapy.

Authors:
Yared Hailemichael Amber Woods Tihui Fu Qiuming He Michael C Nielsen Farah Hasan Jason Roszik Zhilan Xiao Christina Vianden Hiep Khong Manisha Singh Meenu Sharma Faisal Faak Derek Moore Zhimin Dai Scott M Anthony Kimberly S Schluns Padmanee Sharma Victor H Engelhard Willem W Overwijk

J Clin Invest 2018 04 26;128(4):1338-1354. Epub 2018 Feb 26.

Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

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http://dx.doi.org/10.1172/JCI93303DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5873868PMC
April 2018

Nivolumab plus Ipilimumab versus Sunitinib in Advanced Renal-Cell Carcinoma.

Authors:
Robert J Motzer Nizar M Tannir David F McDermott Osvaldo Arén Frontera Bohuslav Melichar Toni K Choueiri Elizabeth R Plimack Philippe Barthélémy Camillo Porta Saby George Thomas Powles Frede Donskov Victoria Neiman Christian K Kollmannsberger Pamela Salman Howard Gurney Robert Hawkins Alain Ravaud Marc-Oliver Grimm Sergio Bracarda Carlos H Barrios Yoshihiko Tomita Daniel Castellano Brian I Rini Allen C Chen Sabeen Mekan M Brent McHenry Megan Wind-Rotolo Justin Doan Padmanee Sharma Hans J Hammers Bernard Escudier

N Engl J Med 2018 Apr 21;378(14):1277-1290. Epub 2018 Mar 21.

From Memorial Sloan Kettering Cancer Center, New York (R.J.M.), and Roswell Park Cancer Institute, Buffalo (S.G.) - both in New York; University of Texas M.D. Anderson Cancer Center, Houston (N.M.T., P. Sharma); Beth Israel Deaconess Medical Center, Dana-Farber/Harvard Cancer Center (D.F.M.), and Dana-Farber Cancer Institute, Brigham and Women's Hospital, and Harvard Medical School (T.K.C.), Boston; Centro Internacional de Estudios Clínicos (O.A.F.) and Fundación Arturo López Pérez (P. Salman), Santiago, Chile; Palacký University and University Hospital Olomouc, Olomouc, Czech Republic (B.M.); Fox Chase Cancer Center, Philadelphia (E.R.P.); Hôpitaux Universitaires de Strasbourg, Strasbourg (P.B.), Bordeaux University Hospital, Hôpital Saint-André, Bordeaux (A.R.), and Institut Gustave Roussy, Villejuif (B.E.) - all in France; Istituto di Ricovero e Cura a Carattere Scientifico San Matteo University Hospital Foundation, Pavia (C.P.), and Ospedale San Donato, Azienda Unità Sanitaria Locale Toscana Sud-Est, Istituto Toscano Tumori, Arezzo (S.B.) - both in Italy; Barts Cancer Institute, Cancer Research UK Experimental Cancer Medicine Centre, Queen Mary University of London, Royal Free NHS Trust (T.P.), and Cancer Research UK (R.H.), London; Aarhus University Hospital, Aarhus, Denmark (F.D.); Davidoff Cancer Center, Rabin Medical Center, Petah Tikva, and Tel Aviv University, Tel Aviv - both in Israel (V.N.); British Columbia Cancer Agency, Vancouver, Canada (C.K.K.); Westmead Hospital and Macquarie University, Sydney (H.G.); Jena University Hospital, Jena, Germany (M.-O.G.); Centro de Pesquisa em Oncologia, Hospital São Lucas, Porto Alegre, Brazil (C.H.B.); Niigata University, Niigata, Japan (Y.T.); Hospital Universitario 12 de Octubre, Madrid (D.C.); Cleveland Clinic Taussig Cancer Institute, Cleveland (B.I.R.); Bristol-Myers Squibb, Princeton, NJ (A.C.C., S.M., M.B.M., M.W.-R., J.D.); and Johns Hopkins Sidney Kimmel Comprehensive Cancer Center, Baltimore (H.J.H.).

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http://www.nejm.org/doi/10.1056/NEJMoa1712126
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5972549PMC
April 2018

Ipilimumab plus Lenalidomide after Allogeneic and Autologous Stem Cell Transplantation for Patients with Lymphoid Malignancies.

Authors:
Issa F Khouri Irina Fernandez Curbelo Francesco Turturro Elias J Jabbour Denái R Milton Roland L Bassett Luis M Vence James P Allison Alison M Gulbis Padmanee Sharma

Clin Cancer Res 2018 03 15;24(5):1011-1018. Epub 2017 Dec 15.

Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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http://dx.doi.org/10.1158/1078-0432.CCR-17-2777DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5844825PMC
March 2018

Robust Antitumor Responses Result from Local Chemotherapy and CTLA-4 Blockade.

Authors:
Charlotte E Ariyan Mary Sue Brady Robert H Siegelbaum Jian Hu Danielle M Bello Jamie Rand Charles Fisher Robert A Lefkowitz Kathleen S Panageas Melissa Pulitzer Marissa Vignali Ryan Emerson Christopher Tipton Harlan Robins Taha Merghoub Jianda Yuan Achim Jungbluth Jorge Blando Padmanee Sharma Alexander Y Rudensky Jedd D Wolchok James P Allison

Cancer Immunol Res 2018 02 16;6(2):189-200. Epub 2018 Jan 16.

Department of Immunology, MD Anderson Cancer Center, Houston, Texas.

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http://dx.doi.org/10.1158/2326-6066.CIR-17-0356DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6857638PMC
February 2018

Neoadjuvant plus adjuvant dabrafenib and trametinib versus standard of care in patients with high-risk, surgically resectable melanoma: a single-centre, open-label, randomised, phase 2 trial.

Authors:
Rodabe N Amaria Peter A Prieto Michael T Tetzlaff Alexandre Reuben Miles C Andrews Merrick I Ross Isabella C Glitza Janice Cormier Wen-Jen Hwu Hussein A Tawbi Sapna P Patel Jeffrey E Lee Jeffrey E Gershenwald Christine N Spencer Vancheswaran Gopalakrishnan Roland Bassett Lauren Simpson Rosalind Mouton Courtney W Hudgens Li Zhao Haifeng Zhu Zachary A Cooper Khalida Wani Alexander Lazar Patrick Hwu Adi Diab Michael K Wong Jennifer L McQuade Richard Royal Anthony Lucci Elizabeth M Burton Sangeetha Reddy Padmanee Sharma James Allison Phillip A Futreal Scott E Woodman Michael A Davies Jennifer A Wargo

Lancet Oncol 2018 02 18;19(2):181-193. Epub 2018 Jan 18.

Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. Electronic address:

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http://dx.doi.org/10.1016/S1470-2045(18)30015-9DOI Listing
February 2018

A potential biomarker for anti-PD-1 immunotherapy.

Authors:
Sangeeta Goswami Sreyashi Basu Padmanee Sharma

Nat Med 2018 02;24(2):123-124

Department of Immunology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

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http://www.nature.com/doifinder/10.1038/nm.4489
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February 2018

CheckMate 025 Randomized Phase 3 Study: Outcomes by Key Baseline Factors and Prior Therapy for Nivolumab Versus Everolimus in Advanced Renal Cell Carcinoma.

Authors:
Bernard Escudier Padmanee Sharma David F McDermott Saby George Hans J Hammers Sandhya Srinivas Scott S Tykodi Jeffrey A Sosman Giuseppe Procopio Elizabeth R Plimack Daniel Castellano Howard Gurney Frede Donskov Katriina Peltola John Wagstaff Thomas C Gauler Takeshi Ueda Huanyu Zhao Ian M Waxman Robert J Motzer

Eur Urol 2017 12 3;72(6):962-971. Epub 2017 Mar 3.

Memorial Sloan Kettering Cancer Center, New York, NY, USA.

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http://dx.doi.org/10.1016/j.eururo.2017.02.010DOI Listing
December 2017

Safety and Efficacy of Nivolumab in Combination With Ipilimumab in Metastatic Renal Cell Carcinoma: The CheckMate 016 Study.

Authors:
Hans J Hammers Elizabeth R Plimack Jeffrey R Infante Brian I Rini David F McDermott Lionel D Lewis Martin H Voss Padmanee Sharma Sumanta K Pal Albiruni R Abdul Razak Christian Kollmannsberger Daniel Y C Heng Jennifer Spratlin M Brent McHenry Asim Amin

J Clin Oncol 2017 Dec 5;35(34):3851-3858. Epub 2017 Jul 5.

Hans J. Hammers, Johns Hopkins Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD; Elizabeth R. Plimack, Fox Chase Cancer Center, Philadelphia, PA; Jeffrey R. Infante, Sarah Cannon Research Institute/Tennessee Oncology, Nashville, TN; Brian I. Rini, Cleveland Clinic Taussig Cancer Institute, Cleveland, OH; David F. McDermott, Beth Israel Deaconess Medical Center, Dana-Farber/Harvard Cancer Center, Boston, MA; Lionel D. Lewis, The Geisel School of Medicine and The Norris Cotton Cancer Center at Dartmouth-Hitchcock Medical Center, Lebanon, NH; Martin H. Voss, Memorial Sloan Kettering Cancer Center, New York, NY; Padmanee Sharma, MD Anderson Cancer Center, University of Texas, Houston, TX; Sumanta K. Pal, City of Hope Comprehensive Cancer Center, Duarte, CA; Albiruni R. Abdul Razak, Princess Margaret Cancer Centre, Toronto, Ontario; Christian Kollmannsberger, British Columbia Cancer Agency, Vancouver, British Columbia; Daniel Y.C. Heng, Tom Baker Cancer Center, University of Calgary, Calgary; Jennifer Spratlin, Cross Cancer Institute, University of Alberta, Edmonton, Alberta, Canada; M. Brent McHenry, Bristol-Myers Squibb, Princeton, NJ; and Asim Amin, Levine Cancer Institute, Carolinas HealthCare System, Charlotte, NC.

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http://ascopubs.org/doi/10.1200/JCO.2016.72.1985
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December 2017

Erythema nodosum-like panniculitis mimicking disease recurrence: A novel toxicity from immune checkpoint blockade therapy-Report of 2 patients.

Authors:
Michael T Tetzlaff Amir A Jazaeri Carlos A Torres-Cabala Brinda R Korivi Genie A Landon Priyadharsini Nagarajan Adrienne Choksi Leon Chen Marc Uemura Phyu P Aung Adi Diab Padmanee Sharma Michael A Davies Rodabe Amaria Victor G Prieto Jonathan L Curry

J Cutan Pathol 2017 Dec 13;44(12):1080-1086. Epub 2017 Oct 13.

Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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http://dx.doi.org/10.1111/cup.13044DOI Listing
December 2017

The Human Cell Atlas.

Authors:
Aviv Regev Sarah A Teichmann Eric S Lander Ido Amit Christophe Benoist Ewan Birney Bernd Bodenmiller Peter Campbell Piero Carninci Menna Clatworthy Hans Clevers Bart Deplancke Ian Dunham James Eberwine Roland Eils Wolfgang Enard Andrew Farmer Lars Fugger Berthold Göttgens Nir Hacohen Muzlifah Haniffa Martin Hemberg Seung Kim Paul Klenerman Arnold Kriegstein Ed Lein Sten Linnarsson Emma Lundberg Joakim Lundeberg Partha Majumder John C Marioni Miriam Merad Musa Mhlanga Martijn Nawijn Mihai Netea Garry Nolan Dana Pe'er Anthony Phillipakis Chris P Ponting Stephen Quake Wolf Reik Orit Rozenblatt-Rosen Joshua Sanes Rahul Satija Ton N Schumacher Alex Shalek Ehud Shapiro Padmanee Sharma Jay W Shin Oliver Stegle Michael Stratton Michael J T Stubbington Fabian J Theis Matthias Uhlen Alexander van Oudenaarden Allon Wagner Fiona Watt Jonathan Weissman Barbara Wold Ramnik Xavier Nir Yosef

Elife 2017 12 5;6. Epub 2017 Dec 5.

Ragon Institute of MGH, MIT and Harvard, Cambridge, United States.

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http://dx.doi.org/10.7554/eLife.27041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5762154PMC
December 2017

TCR Repertoire Intratumor Heterogeneity in Localized Lung Adenocarcinomas: An Association with Predicted Neoantigen Heterogeneity and Postsurgical Recurrence.

Authors:
Alexandre Reuben Rachel Gittelman Jianjun Gao Jiexin Zhang Erik C Yusko Chang-Jiun Wu Ryan Emerson Jianhua Zhang Christopher Tipton Jun Li Kelly Quek Vancheswaran Gopalakrishnan Runzhe Chen Luis M Vence Tina Cascone Marissa Vignali Junya Fujimoto Jaime Rodriguez-Canales Edwin R Parra Latasha D Little Curtis Gumbs Marie-Andrée Forget Lorenzo Federico Cara Haymaker Carmen Behrens Sharon Benzeno Chantale Bernatchez Boris Sepesi Don L Gibbons Jennifer A Wargo William N William Stephen Swisher John V Heymach Harlan Robins J Jack Lee Padmanee Sharma James P Allison P Andrew Futreal Ignacio I Wistuba Jianjun Zhang

Cancer Discov 2017 10 21;7(10):1088-1097. Epub 2017 Jul 21.

Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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http://cancerdiscovery.aacrjournals.org/lookup/doi/10.1158/2
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http://dx.doi.org/10.1158/2159-8290.CD-17-0256DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5628137PMC
October 2017

Harnessing the Immune System Against Leukemia: Monoclonal Antibodies and Checkpoint Strategies for AML.

Authors:
Lucia Masarova Hagop Kantarjian Guillermo Garcia-Mannero Farhad Ravandi Padmanee Sharma Naval Daver

Adv Exp Med Biol 2017 ;995:73-95

Department of Leukemia, MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX, 77030, USA.

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http://dx.doi.org/10.1007/978-3-319-53156-4_4DOI Listing
September 2017

Treatment Beyond Progression in Patients with Advanced Renal Cell Carcinoma Treated with Nivolumab in CheckMate 025.

Authors:
Bernard Escudier Robert J Motzer Padmanee Sharma John Wagstaff Elizabeth R Plimack Hans J Hammers Frede Donskov Howard Gurney Jeffrey A Sosman Pawel G Zalewski Ulrika Harmenberg David F McDermott Toni K Choueiri Martin Richardet Yoshihiko Tomita Alain Ravaud Justin Doan Huanyu Zhao Helene Hardy Saby George

Eur Urol 2017 09 12;72(3):368-376. Epub 2017 Apr 12.

Department of Medicine, Roswell Park Cancer Institute, Buffalo, NY, USA.

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http://dx.doi.org/10.1016/j.eururo.2017.03.037DOI Listing
September 2017

Distinct Cellular Mechanisms Underlie Anti-CTLA-4 and Anti-PD-1 Checkpoint Blockade.

Authors:
Spencer C Wei Jacob H Levine Alexandria P Cogdill Yang Zhao Nana-Ama A S Anang Miles C Andrews Padmanee Sharma Jing Wang Jennifer A Wargo Dana Pe'er James P Allison

Cell 2017 Sep 10;170(6):1120-1133.e17. Epub 2017 Aug 10.

Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Parker Institute for Cancer Immunotherapy, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2017.07.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5591072PMC
September 2017

Erratum to: Society for Immunotherapy of Cancer consensus statement on immunotherapy for the treatment of bladder carcinoma.

Authors:
Ashish M Kamat Joaquim Bellmunt Matthew D Galsky Badrinath R Konety Donald L Lamm David Langham Cheryl T Lee Matthew I Milowsky Michael A O'Donnell Peter H O'Donnell Daniel P Petrylak Padmanee Sharma Eila C Skinner Guru Sonpavde John A Taylor Prasanth Abraham Jonathan E Rosenberg

J Immunother Cancer 2017 09 28;5(1):80. Epub 2017 Sep 28.

Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.

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http://dx.doi.org/10.1186/s40425-017-0280-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5622592PMC
September 2017

Society for Immunotherapy of Cancer consensus statement on immunotherapy for the treatment of bladder carcinoma.

Authors:
Ashish M Kamat Joaquim Bellmunt Matthew D Galsky Badrinath R Konety Donald L Lamm David Langham Cheryl T Lee Matthew I Milowsky Michael A O'Donnell Peter H O'Donnell Daniel P Petrylak Padmanee Sharma Eila C Skinner Guru Sonpavde John A Taylor Prasanth Abraham Jonathan E Rosenberg

J Immunother Cancer 2017 08 15;5(1):68. Epub 2017 Aug 15.

Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.

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http://dx.doi.org/10.1186/s40425-017-0271-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5557323PMC
August 2017

The Phoenix Rises: The Rebirth of Cancer Immunotherapy.

Authors:
Ivan M Blasutig Sofia Farkona Elizabeth I Buchbinder Jason J Luke Padmanee Sharma Mario Sznol

Clin Chem 2017 07 17;63(7):1190-1195. Epub 2017 May 17.

Professor, Internal Medicine, Leader, Melanoma/Renal Cell Disease Research Team, Associate Chief, Section of Medical Oncology, Yale University, New Haven, CT.

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http://dx.doi.org/10.1373/clinchem.2016.267849DOI Listing
July 2017

Genetic biomarker for cancer immunotherapy.

Authors:
Sangeeta Goswami Padmanee Sharma

Science 2017 07;357(6349):358

Department of Genitourinary Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.

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http://dx.doi.org/10.1126/science.aao1894DOI Listing
July 2017

VISTA is an inhibitory immune checkpoint that is increased after ipilimumab therapy in patients with prostate cancer.

Authors:
Jianjun Gao John F Ward Curtis A Pettaway Lewis Z Shi Sumit K Subudhi Luis M Vence Hao Zhao Jianfeng Chen Hong Chen Eleni Efstathiou Patricia Troncoso James P Allison Christopher J Logothetis Ignacio I Wistuba Manuel A Sepulveda Jingjing Sun Jennifer Wargo Jorge Blando Padmanee Sharma

Nat Med 2017 May 27;23(5):551-555. Epub 2017 Mar 27.

Department of Genitourinary Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

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http://dx.doi.org/10.1038/nm.4308DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5466900PMC
May 2017

Erratum: Effective combinatorial immunotherapy for castration-resistant prostate cancer.

Authors:
Xin Lu James W Horner Erin Paul Xiaoying Shang Patricia Troncoso Pingna Deng Shan Jiang Qing Chang Denise J Spring Padmanee Sharma John A Zebala Dean Y Maeda Y Alan Wang Ronald A DePinho

Nature 2017 05;545(7652):116

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http://dx.doi.org/10.1038/nature22348DOI Listing
May 2017

Nivolumab for previously treated unresectable metastatic anal cancer (NCI9673): a multicentre, single-arm, phase 2 study.

Authors:
Van K Morris Mohamed E Salem Halla Nimeiri Syma Iqbal Preet Singh Kristen Ciombor Blase Polite Dustin Deming Emily Chan James L Wade Lianchun Xiao Tanios Bekaii-Saab Luis Vence Jorge Blando Armeen Mahvash Wai Chin Foo Chimela Ohaji Manolo Pasia Gail Bland Aki Ohinata Jane Rogers Amir Mehdizadeh Kimberly Banks Richard Lanman Robert A Wolff Howard Streicher James Allison Padmanee Sharma Cathy Eng

Lancet Oncol 2017 04 18;18(4):446-453. Epub 2017 Feb 18.

The University of Texas-MD Anderson Cancer Center, Houston, TX, USA. Electronic address:

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http://dx.doi.org/10.1016/S1470-2045(17)30104-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5809128PMC
April 2017

Genomic and immune heterogeneity are associated with differential responses to therapy in melanoma.

Authors:
Alexandre Reuben Christine N Spencer Peter A Prieto Vancheswaran Gopalakrishnan Sangeetha M Reddy John P Miller Xizeng Mao Mariana Petaccia De Macedo Jiong Chen Xingzhi Song Hong Jiang Pei-Ling Chen Hannah C Beird Haven R Garber Whijae Roh Khalida Wani Eveline Chen Cara Haymaker Marie-Andrée Forget Latasha D Little Curtis Gumbs Rebecca L Thornton Courtney W Hudgens Wei-Shen Chen Jacob Austin-Breneman Robert Szczepaniak Sloane Luigi Nezi Alexandria P Cogdill Chantale Bernatchez Jason Roszik Patrick Hwu Scott E Woodman Lynda Chin Hussein Tawbi Michael A Davies Jeffrey E Gershenwald Rodabe N Amaria Isabella C Glitza Adi Diab Sapna P Patel Jianhua Hu Jeffrey E Lee Elizabeth A Grimm Michael T Tetzlaff Alexander J Lazar Ignacio I Wistuba Karen Clise-Dwyer Brett W Carter Jianhua Zhang P Andrew Futreal Padmanee Sharma James P Allison Zachary A Cooper Jennifer A Wargo

NPJ Genom Med 2017 7;2. Epub 2017 Apr 7.

Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA.

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http://dx.doi.org/10.1038/s41525-017-0013-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5557036PMC
April 2017

Ipilimumab with Stereotactic Ablative Radiation Therapy: Phase I Results and Immunologic Correlates from Peripheral T Cells.

Authors:
Chad Tang James W Welsh Patricia de Groot Erminia Massarelli Joe Y Chang Kenneth R Hess Sreyashi Basu Michael A Curran Maria E Cabanillas Vivek Subbiah Siqing Fu Apostolia M Tsimberidou Daniel Karp Daniel R Gomez Adi Diab Ritsuko Komaki John V Heymach Padmanee Sharma Aung Naing David S Hong

Clin Cancer Res 2017 Mar 20;23(6):1388-1396. Epub 2016 Sep 20.

Department of Investigational Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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http://dx.doi.org/10.1158/1078-0432.CCR-16-1432DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5355002PMC
March 2017

Nivolumab in metastatic urothelial carcinoma after platinum therapy (CheckMate 275): a multicentre, single-arm, phase 2 trial.

Authors:
Padmanee Sharma Margitta Retz Arlene Siefker-Radtke Ari Baron Andrea Necchi Jens Bedke Elizabeth R Plimack Daniel Vaena Marc-Oliver Grimm Sergio Bracarda José Ángel Arranz Sumanta Pal Chikara Ohyama Abdel Saci Xiaotao Qu Alexandre Lambert Suba Krishnan Alex Azrilevich Matthew D Galsky

Lancet Oncol 2017 03 26;18(3):312-322. Epub 2017 Jan 26.

Division of Hematology and Medical Oncology, Department of Medicine, Icahn School of Medicine at Mount Sinai/Tisch Cancer Institute, New York, NY, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S14702045173006
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http://dx.doi.org/10.1016/S1470-2045(17)30065-7DOI Listing
March 2017

Integrated molecular analysis of tumor biopsies on sequential CTLA-4 and PD-1 blockade reveals markers of response and resistance.

Authors:
Whijae Roh Pei-Ling Chen Alexandre Reuben Christine N Spencer Peter A Prieto John P Miller Vancheswaran Gopalakrishnan Feng Wang Zachary A Cooper Sangeetha M Reddy Curtis Gumbs Latasha Little Qing Chang Wei-Shen Chen Khalida Wani Mariana Petaccia De Macedo Eveline Chen Jacob L Austin-Breneman Hong Jiang Jason Roszik Michael T Tetzlaff Michael A Davies Jeffrey E Gershenwald Hussein Tawbi Alexander J Lazar Patrick Hwu Wen-Jen Hwu Adi Diab Isabella C Glitza Sapna P Patel Scott E Woodman Rodabe N Amaria Victor G Prieto Jianhua Hu Padmanee Sharma James P Allison Lynda Chin Jianhua Zhang Jennifer A Wargo P Andrew Futreal

Sci Transl Med 2017 03;9(379)

Department of Genomic Medicine, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

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http://dx.doi.org/10.1126/scitranslmed.aah3560DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5819607PMC
March 2017

Effective combinatorial immunotherapy for castration-resistant prostate cancer.

Authors:
Xin Lu James W Horner Erin Paul Xiaoying Shang Patricia Troncoso Pingna Deng Shan Jiang Qing Chang Denise J Spring Padmanee Sharma John A Zebala Dean Y Maeda Y Alan Wang Ronald A DePinho

Nature 2017 03 20;543(7647):728-732. Epub 2017 Mar 20.

Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1038/nature21676DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5374023PMC
March 2017

Suppression of Type I IFN Signaling in Tumors Mediates Resistance to Anti-PD-1 Treatment That Can Be Overcome by Radiotherapy.

Authors:
Xiaohong Wang Jonathan E Schoenhals Ailin Li David R Valdecanas Huiping Ye Fenglin Zang Chad Tang Ming Tang Chang-Gong Liu Xiuping Liu Sunil Krishnan James P Allison Padmanee Sharma Patrick Hwu Ritsuko Komaki Willem W Overwijk Daniel R Gomez Joe Y Chang Stephen M Hahn Maria Angelica Cortez James W Welsh

Cancer Res 2017 02 7;77(4):839-850. Epub 2016 Nov 7.

Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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http://dx.doi.org/10.1158/0008-5472.CAN-15-3142DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5875182PMC
February 2017

Metastatic Melanoma Patient Had a Complete Response with Clonal Expansion after Whole Brain Radiation and PD-1 Blockade.

Authors:
Cara L Haymaker DaeWon Kim Marc Uemura Luis M Vence Ann Phillip Natalie McQuail Paul D Brown Irina Fernandez Courtney W Hudgens Caitlin Creasy Wen-Jen Hwu Padmanee Sharma Michael T Tetzlaff James P Allison Patrick Hwu Chantale Bernatchez Adi Diab

Cancer Immunol Res 2017 02 6;5(2):100-105. Epub 2017 Jan 6.

Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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http://dx.doi.org/10.1158/2326-6066.CIR-16-0223DOI Listing
February 2017

Primary, Adaptive, and Acquired Resistance to Cancer Immunotherapy.

Authors:
Padmanee Sharma Siwen Hu-Lieskovan Jennifer A Wargo Antoni Ribas

Cell 2017 02;168(4):707-723

Department of Medicine, Division of Hematology-Oncology, University of California, Los Angeles and the Jonsson Comprehensive Cancer Center, Los Angeles, CA 90095, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2017.01.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5391692PMC
February 2017

Intratumoral modulation of the inducible co-stimulator ICOS by recombinant oncolytic virus promotes systemic anti-tumour immunity.

Authors:
Dmitriy Zamarin Rikke B Holmgaard Jacob Ricca Tamar Plitt Peter Palese Padmanee Sharma Taha Merghoub Jedd D Wolchok James P Allison

Nat Commun 2017 02 13;8:14340. Epub 2017 Feb 13.

Department of Immunology, MD Anderson Cancer Center, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1038/ncomms14340DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5316835PMC
February 2017

From the Guest Editor: Immune Checkpoint Therapy as a Weapon Against Cancer.

Authors:
Padmanee Sharma

Cancer J 2016 Mar-Apr;22(2):67

From the Departments of Genitourinary Medical Oncology and Immunology, M. D. Anderson Cancer Center, Houston, TX.

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http://dx.doi.org/10.1097/PPO.0000000000000184DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4847147PMC
January 2017

Immune Checkpoint Therapy and the Search for Predictive Biomarkers.

Authors:
Padmanee Sharma

Cancer J 2016 Mar-Apr;22(2):68-72

From the Departments of Immunology and Genitourinary Medical Oncology, M. D. Anderson Cancer Center, Houston, TX.P.S.'s work was supported by the SU2C-CRI Dream Team Cancer Immunotherapy Grant, PCF Challenge Grant in Immunology, NCI/NIH 1-R01 CA1633793-01, and Cancer Prevention Research in Texas (grant RP120108).

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http://dx.doi.org/10.1097/PPO.0000000000000185DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4847150PMC
January 2017

A Pilot Study of Preoperative Single-Dose Ipilimumab and/or Cryoablation in Women with Early-Stage Breast Cancer with Comprehensive Immune Profiling.

Authors:
Heather L McArthur Adi Diab David B Page Jianda Yuan Stephen B Solomon Virgilio Sacchini Christopher Comstock Jeremy C Durack Majid Maybody Janice Sung Arielle Ginsberg Phillip Wong Afsar Barlas Zhiwan Dong Chunjun Zhao Brian Blum Sujata Patil Deirdre Neville Elizabeth A Comen Elizabeth A Morris Alan Kotin Edi Brogi Y Hannah Wen Monica Morrow Mario E Lacouture Padmanee Sharma James P Allison Clifford A Hudis Jedd D Wolchok Larry Norton

Clin Cancer Res 2016 Dec 26;22(23):5729-5737. Epub 2016 Aug 26.

Memorial Sloan Kettering Cancer Center (MSKCC), New York, New York.

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http://clincancerres.aacrjournals.org/cgi/doi/10.1158/1078-0
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http://dx.doi.org/10.1158/1078-0432.CCR-16-0190DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5161031PMC
December 2016

Nivolumab monotherapy in recurrent metastatic urothelial carcinoma (CheckMate 032): a multicentre, open-label, two-stage, multi-arm, phase 1/2 trial.

Authors:
Padmanee Sharma Margaret K Callahan Petri Bono Joseph Kim Pavlina Spiliopoulou Emiliano Calvo Rathi N Pillai Patrick A Ott Filippo de Braud Michael Morse Dung T Le Dirk Jaeger Emily Chan Chris Harbison Chen-Sheng Lin Marina Tschaika Alex Azrilevich Jonathan E Rosenberg

Lancet Oncol 2016 Nov 9;17(11):1590-1598. Epub 2016 Oct 9.

Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

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http://dx.doi.org/10.1016/S1470-2045(16)30496-XDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5648054PMC
November 2016

Loss of IFN-γ Pathway Genes in Tumor Cells as a Mechanism of Resistance to Anti-CTLA-4 Therapy.

Authors:
Jianjun Gao Lewis Zhichang Shi Hao Zhao Jianfeng Chen Liangwen Xiong Qiuming He Tenghui Chen Jason Roszik Chantale Bernatchez Scott E Woodman Pei-Ling Chen Patrick Hwu James P Allison Andrew Futreal Jennifer A Wargo Padmanee Sharma

Cell 2016 Oct 22;167(2):397-404.e9. Epub 2016 Sep 22.

Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. Electronic address:

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5088716PMC
http://dx.doi.org/10.1016/j.cell.2016.08.069DOI Listing
October 2016

Clonal expansion of CD8 T cells in the systemic circulation precedes development of ipilimumab-induced toxicities.

Authors:
Sumit K Subudhi Ana Aparicio Jianjun Gao Amado J Zurita John C Araujo Christopher J Logothetis Salahaldin A Tahir Brinda R Korivi Rebecca S Slack Luis Vence Ryan O Emerson Erik Yusko Marissa Vignali Harlan S Robins Jingjing Sun James P Allison Padmanee Sharma

Proc Natl Acad Sci U S A 2016 10 3;113(42):11919-11924. Epub 2016 Oct 3.

Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030; Immunotherapy Platform, The University of Texas MD Anderson Cancer Center, Houston, TX 77030; Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030

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http://dx.doi.org/10.1073/pnas.1611421113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5081579PMC
October 2016

Selective inhibition of autoimmune exacerbation while preserving the anti-tumor clinical benefit using IL-6 blockade in a patient with advanced melanoma and Crohn's disease: a case report.

Authors:
Marc Uemura Van A Trinh Cara Haymaker Natalie Jackson Dae Won Kim James P Allison Padmanee Sharma Luis Vence Chantale Bernatchez Patrick Hwu Adi Diab

J Hematol Oncol 2016 09 5;9(1):81. Epub 2016 Sep 5.

DDepartment of Melanoma Medical Oncology, University of Texas-MD Anderson Cancer Center, 1515 Holcolmbe Blvd., Houston, TX, 77030, USA.

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http://dx.doi.org/10.1186/s13045-016-0309-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5011857PMC
September 2016

Strategies for combining immunotherapy with radiation for anticancer therapy.

Authors:
Steven N Seyedin Jonathan E Schoenhals Dean A Lee Maria A Cortez Xiaohong Wang Sharareh Niknam Chad Tang David S Hong Aung Naing Padmanee Sharma James P Allison Joe Y Chang Daniel R Gomez John V Heymach Ritsuko U Komaki Laurence J Cooper James W Welsh

Immunotherapy 2015 27;7(9):967-980. Epub 2015 Aug 27.

Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA.

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http://dx.doi.org/10.2217/imt.15.65DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4825325PMC
August 2016

Monitoring immune responses in the tumor microenvironment.

Authors:
Jennifer A Wargo Sangeetha M Reddy Alexandre Reuben Padmanee Sharma

Curr Opin Immunol 2016 08 27;41:23-31. Epub 2016 May 27.

Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, 1155 Pressler Street, Unit 1374, Houston, TX 77030, USA. Electronic address:

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http://dx.doi.org/10.1016/j.coi.2016.05.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5257261PMC
August 2016

Analysis of Immune Signatures in Longitudinal Tumor Samples Yields Insight into Biomarkers of Response and Mechanisms of Resistance to Immune Checkpoint Blockade.

Authors:
Pei-Ling Chen Whijae Roh Alexandre Reuben Zachary A Cooper Christine N Spencer Peter A Prieto John P Miller Roland L Bassett Vancheswaran Gopalakrishnan Khalida Wani Mariana Petaccia De Macedo Jacob L Austin-Breneman Hong Jiang Qing Chang Sangeetha M Reddy Wei-Shen Chen Michael T Tetzlaff Russell J Broaddus Michael A Davies Jeffrey E Gershenwald Lauren Haydu Alexander J Lazar Sapna P Patel Patrick Hwu Wen-Jen Hwu Adi Diab Isabella C Glitza Scott E Woodman Luis M Vence Ignacio I Wistuba Rodabe N Amaria Lawrence N Kwong Victor Prieto R Eric Davis Wencai Ma Willem W Overwijk Arlene H Sharpe Jianhua Hu P Andrew Futreal Jorge Blando Padmanee Sharma James P Allison Lynda Chin Jennifer A Wargo

Cancer Discov 2016 08 14;6(8):827-37. Epub 2016 Jun 14.

Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas. Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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http://cancerdiscovery.aacrjournals.org/cgi/doi/10.1158/2159
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5082984PMC
http://dx.doi.org/10.1158/2159-8290.CD-15-1545DOI Listing
August 2016

Interdependent IL-7 and IFN-γ signalling in T-cell controls tumour eradication by combined α-CTLA-4+α-PD-1 therapy.

Authors:
Lewis Zhichang Shi Tihui Fu Baoxiang Guan Jianfeng Chen Jorge M Blando James P Allison Liangwen Xiong Sumit K Subudhi Jianjun Gao Padmanee Sharma

Nat Commun 2016 08 8;7:12335. Epub 2016 Aug 8.

Department of Genitourinary Medical Oncology, MD Anderson Cancer Center, Houston, Texas 77030, USA.

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http://www.nature.com/articles/ncomms12335
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http://dx.doi.org/10.1038/ncomms12335DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4979067PMC
August 2016

ICOS Promotes the Function of CD4+ Effector T Cells during Anti-OX40-Mediated Tumor Rejection.

Authors:
Todd C Metzger Hua Long Shobha Potluri Thomas Pertel Samantha L Bailey-Bucktrout John C Lin Tihui Fu Padmanee Sharma James P Allison Reid M R Feldman

Cancer Res 2016 07 4;76(13):3684-9. Epub 2016 May 4.

Rinat Laboratories, Pfizer Inc., South San Francisco, California.

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http://dx.doi.org/10.1158/0008-5472.CAN-15-3412DOI Listing
July 2016

Nivolumab alone and nivolumab plus ipilimumab in recurrent small-cell lung cancer (CheckMate 032): a multicentre, open-label, phase 1/2 trial.

Authors:
Scott J Antonia José A López-Martin Johanna Bendell Patrick A Ott Matthew Taylor Joseph Paul Eder Dirk Jäger M Catherine Pietanza Dung T Le Filippo de Braud Michael A Morse Paolo A Ascierto Leora Horn Asim Amin Rathi N Pillai Jeffry Evans Ian Chau Petri Bono Akin Atmaca Padmanee Sharma Christopher T Harbison Chen-Sheng Lin Olaf Christensen Emiliano Calvo

Lancet Oncol 2016 Jul 4;17(7):883-895. Epub 2016 Jun 4.

START Madrid, Centro Integral Oncológico Clara Campal, Madrid, Spain. Electronic address:

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http://dx.doi.org/10.1016/S1470-2045(16)30098-5DOI Listing
July 2016

Acute rhabdomyolysis with severe polymyositis following ipilimumab-nivolumab treatment in a cancer patient with elevated anti-striated muscle antibody.

Authors:
Mehmet Asim Bilen Sumit K Subudhi Jianjun Gao Nizar M Tannir Shi-Ming Tu Padmanee Sharma

J Immunother Cancer 2016 21;4:36. Epub 2016 Jun 21.

Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Unit 1374, 1155 Pressler Street, Houston, TX 77030-3721 USA.

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http://dx.doi.org/10.1186/s40425-016-0139-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4915058PMC
June 2016

Distinct clinical patterns and immune infiltrates are observed at time of progression on targeted therapy versus immune checkpoint blockade for melanoma.

Authors:
Zachary A Cooper Alexandre Reuben Christine N Spencer Peter A Prieto Jacob L Austin-Breneman Hong Jiang Cara Haymaker Vancheswaran Gopalakrishnan Michael T Tetzlaff Dennie T Frederick Ryan J Sullivan Rodabe N Amaria Sapna P Patel Patrick Hwu Scott E Woodman Isabella C Glitza Adi Diab Luis M Vence Jaime Rodriguez-Canales Edwin R Parra Ignacio I Wistuba Lisa M Coussens Arlene H Sharpe Keith T Flaherty Jeffrey E Gershenwald Lynda Chin Michael A Davies Karen Clise-Dwyer James P Allison Padmanee Sharma Jennifer A Wargo

Oncoimmunology 2016 Mar 2;5(3):e1136044. Epub 2016 Feb 2.

Department of Surgical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA; Genomic Medicine, University of Texas MD Anderson Cancer Center, Houston, TX, USA.

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http://dx.doi.org/10.1080/2162402X.2015.1136044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4839346PMC
March 2016

Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival.

Authors:
Berna C Özdemir Tsvetelina Pentcheva-Hoang Julienne L Carstens Xiaofeng Zheng Chia-Chin Wu Tyler R Simpson Hanane Laklai Hikaru Sugimoto Christoph Kahlert Sergey V Novitskiy Ana De Jesus-Acosta Padmanee Sharma Pedram Heidari Umar Mahmood Lynda Chin Harold L Moses Valerie M Weaver Anirban Maitra James P Allison Valerie S LeBleu Raghu Kalluri

Cancer Cell 2015 Dec 14;28(6):831-833. Epub 2015 Dec 14.

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http://dx.doi.org/10.1016/j.ccell.2015.11.002DOI Listing
December 2015

Nivolumab versus Everolimus in Advanced Renal-Cell Carcinoma.

Authors:
Robert J Motzer Bernard Escudier David F McDermott Saby George Hans J Hammers Sandhya Srinivas Scott S Tykodi Jeffrey A Sosman Giuseppe Procopio Elizabeth R Plimack Daniel Castellano Toni K Choueiri Howard Gurney Frede Donskov Petri Bono John Wagstaff Thomas C Gauler Takeshi Ueda Yoshihiko Tomita Fabio A Schutz Christian Kollmannsberger James Larkin Alain Ravaud Jason S Simon Li-An Xu Ian M Waxman Padmanee Sharma

N Engl J Med 2015 Nov 25;373(19):1803-13. Epub 2015 Sep 25.

From Memorial Sloan Kettering Cancer Center, New York (R.J.M.), and Roswell Park Cancer Institute, Buffalo (S.G.) - both in New York; Institut Gustave Roussy, Villejuif (B.E.), and Bordeaux University Hospital, Hôpital Saint André, Bordeaux (A.R.) - both in France; Beth Israel Deaconess Medical Center (D.F.M.) and Dana-Farber Cancer Institute, Brigham and Women's Hospital, and Harvard Medical School (T.K.C.) - all in Boston; Johns Hopkins Sidney Kimmel Comprehensive Cancer Center, Baltimore (H.J.H.); Stanford Cancer Institute, Stanford, CA (S.S.); University of Washington and Fred Hutchinson Cancer Research Center, Seattle (S.S.T.); Vanderbilt University Medical Center, Nashville (J.A.S.); Fondazione Istituto Nazionale Tumori, Milan (G.P.); Fox Chase Cancer Center, Philadelphia (E.R.P.); Hospital Universitario 12 De Octubre, Madrid (D.C.); Westmead Hospital and Macquarie University, Sydney (H.G.); Aarhus University Hospital, Aarhus, Denmark (F.D.); Helsinki University Central Hospital and University of Helsinki, Helsinki (P.B.); South West Wales Cancer Institute and Swansea University College of Medicine, Swansea (J.W.), and Royal Marsden Hospital, London (J.L.) - both in the United Kingdom; University Hospital Essen of University of Duisburg-Essen, Germany (T.C.G.); Chiba Cancer Center, Chiba (T.U.), and Niigata University, Niigata (Y.T.) - both in Japan; Hospital Sao Jose, Beneficencia Portuguesa de São Paulo, São Paulo (F.A.S.); British Columbia Cancer Agency, Vancouver, BC, Canada (C.K.); Bristol-Myers Squibb, Lawrenceville (J.S.S., I.M.W.) and Hopewell (L.-A.X.) - both in New Jersey; and M.D. Anderson Cancer Center, University of Texas, Houston (P.S.).

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http://dx.doi.org/10.1056/NEJMoa1510665DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5719487PMC
November 2015

Targeting the tumor niche to treat cancer.

Authors:
Sattva S Neelapu Padmanee Sharma

Proc Natl Acad Sci U S A 2015 Oct 8;112(42):12907-8. Epub 2015 Oct 8.

Center for Cancer Immunology Research, The University of Texas MD Anderson Cancer Center, Houston, TX 77030; Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030; Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030

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http://dx.doi.org/10.1073/pnas.1517389112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4620886PMC
October 2015

Resistance to Antiangiogenic Therapy Is Associated with an Immunosuppressive Tumor Microenvironment in Metastatic Renal Cell Carcinoma.

Authors:
Xian-De Liu Anh Hoang Lijun Zhou Sarathi Kalra Alper Yetil Mianen Sun Zhiyong Ding Xuesong Zhang Shanshan Bai Peter German Pheroze Tamboli Priya Rao Jose A Karam Christopher Wood Surena Matin Amado Zurita Axel Bex Arjan W Griffioen Jianjun Gao Padmanee Sharma Nizar Tannir Kanishka Sircar Eric Jonasch

Cancer Immunol Res 2015 Sep 26;3(9):1017-29. Epub 2015 May 26.

Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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http://dx.doi.org/10.1158/2326-6066.CIR-14-0244DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4561186PMC
September 2015

Co-occurring genomic alterations define major subsets of KRAS-mutant lung adenocarcinoma with distinct biology, immune profiles, and therapeutic vulnerabilities.

Authors:
Ferdinandos Skoulidis Lauren A Byers Lixia Diao Vassiliki A Papadimitrakopoulou Pan Tong Julie Izzo Carmen Behrens Humam Kadara Edwin R Parra Jaime Rodriguez Canales Jianjun Zhang Uma Giri Jayanthi Gudikote Maria A Cortez Chao Yang Youhong Fan Michael Peyton Luc Girard Kevin R Coombes Carlo Toniatti Timothy P Heffernan Murim Choi Garrett M Frampton Vincent Miller John N Weinstein Roy S Herbst Kwok-Kin Wong Jianhua Zhang Padmanee Sharma Gordon B Mills Waun K Hong John D Minna James P Allison Andrew Futreal Jing Wang Ignacio I Wistuba John V Heymach

Cancer Discov 2015 Aug 11;5(8):860-77. Epub 2015 Jun 11.

Department of Thoracic and Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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http://cancerdiscovery.aacrjournals.org/content/early/2015/0
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http://cancerdiscovery.aacrjournals.org/cgi/doi/10.1158/2159
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http://dx.doi.org/10.1158/2159-8290.CD-14-1236DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4527963PMC
August 2015

The future of immune checkpoint therapy.

Authors:
Padmanee Sharma James P Allison

Science 2015 Apr;348(6230):56-61

Department of Immunology, M.D. Anderson Cancer Center, Houston, TX, USA.

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http://dx.doi.org/10.1126/science.aaa8172DOI Listing
April 2015

Immune checkpoint targeting in cancer therapy: toward combination strategies with curative potential.

Authors:
Padmanee Sharma James P Allison

Cell 2015 Apr;161(2):205-14

Department of Immunology, MD Anderson Cancer Center, Houston, TX 77030, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2015.03.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5905674PMC
April 2015

Combining radiation and immunotherapy: a new systemic therapy for solid tumors?

Authors:
Chad Tang Xiaohong Wang Hendrick Soh Steven Seyedin Maria Angelica Cortez Sunil Krishnan Erminia Massarelli David Hong Aung Naing Adi Diab Daniel Gomez Huiping Ye John Heymach Ristuko Komaki James P Allison Padmanee Sharma James W Welsh

Cancer Immunol Res 2014 Sep;2(9):831-8

Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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http://dx.doi.org/10.1158/2326-6066.CIR-14-0069DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5367158PMC
September 2014

Cancer immunotherapy highlights from the 2014 ASCO Meeting.

Authors:
Lauren C Harshman Charles G Drake Jennifer A Wargo Padmanee Sharma Nina Bhardwaj

Cancer Immunol Res 2014 Aug;2(8):714-9

Icahn School of Medicine at Mount Sinai, New York, New York

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http://dx.doi.org/10.1158/2326-6066.CIR-14-0119DOI Listing
August 2014

Depletion of carcinoma-associated fibroblasts and fibrosis induces immunosuppression and accelerates pancreas cancer with reduced survival.

Authors:
Berna C Özdemir Tsvetelina Pentcheva-Hoang Julienne L Carstens Xiaofeng Zheng Chia-Chin Wu Tyler R Simpson Hanane Laklai Hikaru Sugimoto Christoph Kahlert Sergey V Novitskiy Ana De Jesus-Acosta Padmanee Sharma Pedram Heidari Umar Mahmood Lynda Chin Harold L Moses Valerie M Weaver Anirban Maitra James P Allison Valerie S LeBleu Raghu Kalluri

Cancer Cell 2014 Jun 22;25(6):719-34. Epub 2014 May 22.

Department of Cancer Biology, Metastasis Research Center, University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA; Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccr.2014.04.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4180632PMC
June 2014

Tumor immunology and cancer immunotherapy: summary of the 2013 SITC primer.

Authors:
Raju R Raval Andrew B Sharabi Amanda J Walker Charles G Drake Padmanee Sharma

J Immunother Cancer 2014 14;2:14. Epub 2014 May 14.

Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA ; Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

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http://dx.doi.org/10.1186/2051-1426-2-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4039332PMC
June 2014

Engagement of the ICOS pathway markedly enhances efficacy of CTLA-4 blockade in cancer immunotherapy.

Authors:
Xiaozhou Fan Sergio A Quezada Manuel A Sepulveda Padmanee Sharma James P Allison

J Exp Med 2014 Apr 31;211(4):715-25. Epub 2014 Mar 31.

Department of Immunology and 2 Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030.

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http://dx.doi.org/10.1084/jem.20130590DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3978270PMC
April 2014

PD-L1 expression in triple-negative breast cancer.

Authors:
Elizabeth A Mittendorf Anne V Philips Funda Meric-Bernstam Na Qiao Yun Wu Susan Harrington Xiaoping Su Ying Wang Ana M Gonzalez-Angulo Argun Akcakanat Akhil Chawla Michael Curran Patrick Hwu Padmanee Sharma Jennifer K Litton Jeffrey J Molldrem Gheath Alatrash

Cancer Immunol Res 2014 Apr 10;2(4):361-70. Epub 2014 Jan 10.

Authors' Affiliations: Departments of Department of Urology, The Mayo Clinic, Rochester, Minnesota.

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http://dx.doi.org/10.1158/2326-6066.CIR-13-0127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4000553PMC
April 2014

CD4 T cells require ICOS-mediated PI3K signaling to increase T-Bet expression in the setting of anti-CTLA-4 therapy.

Authors:
Hong Chen Tihui Fu Woong-Kyung Suh Dimitra Tsavachidou Sijin Wen Jianjun Gao Derek Ng Tang Qiuming He Jingjing Sun Padmanee Sharma

Cancer Immunol Res 2014 Feb 19;2(2):167-76. Epub 2013 Nov 19.

Authors' Affiliations: IRCM (Institut de recherches cliniques de Montreal) and Department of Medicine, University of Montreal, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1158/2326-6066.CIR-13-0155DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4004958PMC
February 2014

Increased frequency of ICOS+ CD4 T cells as a pharmacodynamic biomarker for anti-CTLA-4 therapy.

Authors:
Derek Ng Tang Yu Shen Jingjing Sun Sijin Wen Jedd D Wolchok Jianda Yuan James P Allison Padmanee Sharma

Cancer Immunol Res 2013 Oct 31;1(4):229-34. Epub 2013 Jul 31.

Authors' Affiliations: Ludwig Center for Cancer Immunotherapy, Memorial Sloan-Kettering Cancer Center, New York, New York.

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http://dx.doi.org/10.1158/2326-6066.CIR-13-0020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4636341PMC
October 2013

Harnessing the power of the immune system to target cancer.

Authors:
Gregory Lizée Willem W Overwijk Laszlo Radvanyi Jianjun Gao Padmanee Sharma Patrick Hwu

Annu Rev Med 2013 22;64:71-90. Epub 2012 Oct 22.

Department of Melanoma Medical Oncology, The Center for Cancer Immunology Research, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA.

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http://www.annualreviews.org/doi/10.1146/annurev-med-112311-
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http://dx.doi.org/10.1146/annurev-med-112311-083918DOI Listing
July 2013