Pablo Pelegrin

Pablo Pelegrin

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Pablo Pelegrin

Pablo Pelegrin

Publications by authors named "Pablo Pelegrin"

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3D chitosan scaffolds impair NLRP3 inflammasome response in macrophages.

Acta Biomater 2019 Jun 17;91:123-134. Epub 2019 Apr 17.

i3S - Instituto de Inovação e Investigação em Saúde, Universidade do Porto, Rua Alfredo Allen, 208, 4200-125 Porto, Portugal; INEB - Instituto de Engenharia Biomédica, Rua Alfredo Allen, 208, 4200-125 Porto, Portugal; ICBAS - Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S17427061193027
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http://dx.doi.org/10.1016/j.actbio.2019.04.035DOI Listing
June 2019

MCC950 closes the active conformation of NLRP3 to an inactive state.

Nat Chem Biol 2019 Jun 13;15(6):560-564. Epub 2019 May 13.

Biomedical Research Institute of Murcia (IMIB-Arrixaca), University Clinical Hospital Virgen de la Arrixaca, Murcia, Spain.

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http://www.nature.com/articles/s41589-019-0278-6
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http://dx.doi.org/10.1038/s41589-019-0278-6DOI Listing
June 2019

Purinergic receptors and the inflammatory response mediated by lipids.

Curr Opin Pharmacol 2019 Apr 2;47:90-96. Epub 2019 Apr 2.

Instituto Murciano de Investigación Biosanitaria IMIB-Arrixaca, Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.coph.2019.02.004DOI Listing
April 2019

Early endosome autoantigen 1 regulates IL-1β release upon caspase-1 activation independently of gasdermin D membrane permeabilization.

Sci Rep 2019 Apr 8;9(1):5788. Epub 2019 Apr 8.

Inflammation and Experimental Surgery Unit, Biomedical Research Institute of Murcia IMIB-Arrixaca, Clinical University Hospital Virgen de la Arrixaca, 30120, Murcia, Spain.

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http://dx.doi.org/10.1038/s41598-019-42298-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6453936PMC
April 2019

The inflammasome in host response to biomaterials: Bridging inflammation and tissue regeneration.

Acta Biomater 2019 Jan 29;83:1-12. Epub 2018 Sep 29.

i3S - Instituto de Inovação e Investigação em Saúde, Universidade do Porto, Rua Alfredo Allen, 208, 4200-125 Porto, Portugal; INEB - Instituto de Engenharia Biomédica, Rua Alfredo Allen, 208, 4200-125 Porto, Portugal; ICBAS - Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S17427061183058
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http://dx.doi.org/10.1016/j.actbio.2018.09.056DOI Listing
January 2019

NLRP3 lacking the leucine-rich repeat domain can be fully activated via the canonical inflammasome pathway.

Nat Commun 2018 12 5;9(1):5182. Epub 2018 Dec 5.

Department of Synthetic Biology and Immunology, National Institute of Chemistry, Hajdrihova 19, 1000, Ljubljana, Slovenia.

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http://dx.doi.org/10.1038/s41467-018-07573-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6281599PMC
December 2018

Chloride regulates dynamic NLRP3-dependent ASC oligomerization and inflammasome priming.

Proc Natl Acad Sci U S A 2018 10 19;115(40):E9371-E9380. Epub 2018 Sep 19.

Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, M13 9PT Manchester, United Kingdom;

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http://www.pnas.org/lookup/doi/10.1073/pnas.1812744115
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http://dx.doi.org/10.1073/pnas.1812744115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6176575PMC
October 2018

Methods to Study Cell Swelling-Induced Inflammasome Activation.

Methods Mol Biol 2018 ;1714:191-197

Molecular Inflammation Unit, Biomedical Research Institute of Murcia (IMIB-Arrixaca), Clinical University Hospital Virgen de la Arrixaca, University of Murcia, LAIB building, Room 4.15, Carretera Buenavista, s/n, 30120 El Palmar, Murcia, Spain.

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http://link.springer.com/10.1007/978-1-4939-7519-8_12
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http://dx.doi.org/10.1007/978-1-4939-7519-8_12DOI Listing
July 2018

Ion homeostasis and ion channels in NLRP3 inflammasome activation and regulation.

Curr Opin Immunol 2018 06 16;52:8-17. Epub 2018 Mar 16.

Molecular Inflammation Group, Biomedical Research Institute of Murcia (IMIB-Arrixaca), University Clinical Hospital "Virgen de la Arrixaca", University of Murcia, Carretera Buenavista s/n, 30120 El Palmar, Murcia, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.coi.2018.03.010DOI Listing
June 2018

Measuring IL-1β Processing by Bioluminescence Sensors I: Using a Bioluminescence Resonance Energy Transfer Biosensor.

Methods Mol Biol 2016 ;1417:89-95

Molecular Inflammation Group, Murcia Biomedical Research Institute (IMIB-Arrixaca), Hospital Virgen de la Arrixaca, Carretera Buenavista, s/n, Murcia, 30120, Spain.

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http://dx.doi.org/10.1007/978-1-4939-3566-6_5DOI Listing
December 2017

Measuring NLR Oligomerization III: Detection of NLRP3 Complex by Bioluminescence Resonance Energy Transfer.

Methods Mol Biol 2016 ;1417:159-68

Molecular Inflammation Group, Murcia Biomedical Research Institute (IMIB-Arrixaca), Hospital Virgen de la Arrixaca, Carretera Buenavista, s/n., Murcia, 30120, Spain.

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http://dx.doi.org/10.1007/978-1-4939-3566-6_10DOI Listing
December 2017

Extracellular ATP Activates the NLRP3 Inflammasome and Is an Early Danger Signal of Skin Allograft Rejection.

Cell Rep 2017 Dec;21(12):3414-3426

Experimental Surgery Group, Biomedical Research Institute of Murcia (IMIB-Arrixaca), University Clinical Hospital Virgen de la Arrixaca, 30120 Murcia, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.11.079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5746605PMC
December 2017

An emerging case for membrane pore formation as a common mechanism for the unconventional secretion of FGF2 and IL-1β.

J Cell Sci 2017 Oct 4;130(19):3197-3202. Epub 2017 Sep 4.

Heidelberg University Biochemistry Center, Im Neuenheimer Feld 328, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.1242/jcs.204206DOI Listing
October 2017

M1 and M2 Functional Imprinting of Primary Microglia: Role of P2X7 Activation and miR-125b.

Mediators Inflamm 2016 20;2016:2989548. Epub 2016 Dec 20.

CNR-Institute of Cell Biology and Neurobiology, Via del Fosso di Fiorano 65, 00143 Rome, Italy; Fondazione Santa Lucia, Via del Fosso di Fiorano 65, 00143 Rome, Italy.

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http://dx.doi.org/10.1155/2016/2989548DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5206439PMC
August 2017

Lytic cell death induced by melittin bypasses pyroptosis but induces NLRP3 inflammasome activation and IL-1β release.

Cell Death Dis 2017 08 10;8(8):e2984. Epub 2017 Aug 10.

Inflammation and Experimental Surgery Unit, Biomedical Research Institute of Murcia IMIB-Arrixaca, University Clinical Hospital Virgen de la Arrixaca, Murcia 30120, Spain.

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http://www.nature.com/doifinder/10.1038/cddis.2017.390
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http://dx.doi.org/10.1038/cddis.2017.390DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5596576PMC
August 2017

P2X7 Receptor Induces Tumor Necrosis Factor-α Converting Enzyme Activation and Release to Boost TNF-α Production.

Front Immunol 2017 24;8:862. Epub 2017 Jul 24.

Biomedical Research Institute of Murcia (IMIB-Arrixaca), Clinical University Hospital Virgen de la Arrixaca, Murcia, Spain.

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http://dx.doi.org/10.3389/fimmu.2017.00862DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5523084PMC
July 2017

Reprogramming macrophages by plasmin.

Authors:
Pablo Pelegrín

Blood 2017 05;129(21):2823-2824

BIOMEDICAL RESEARCH INSTITUTE OF MURCIA.

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http://dx.doi.org/10.1182/blood-2017-04-776377DOI Listing
May 2017

Inflammasomes in Liver Fibrosis.

Semin Liver Dis 2017 05 31;37(2):119-127. Epub 2017 May 31.

Department of Pediatric Gastroenterology, University of California San Diego (UCSD), and Rady Children's Hospital, San Diego, California.

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http://dx.doi.org/10.1055/s-0037-1601350DOI Listing
May 2017

Lipin-2 regulates NLRP3 inflammasome by affecting P2X7 receptor activation.

J Exp Med 2017 02 28;214(2):511-528. Epub 2016 Dec 28.

Instituto de Biología y Genética Molecular, Consejo Superior de Investigaciones Científicas, Universidad de Valladolid, 47003 Valladolid, Spain

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http://dx.doi.org/10.1084/jem.20161452DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5294860PMC
February 2017

The NLRP3 and Pyrin Inflammasomes: Implications in the Pathophysiology of Autoinflammatory Diseases.

Front Immunol 2017 27;8:43. Epub 2017 Jan 27.

Unidad de Inflamación Molecular, Instituto Murciano de Investigación Biosanitaria-Virgen de la Arrixaca (IMIB-Arrixaca), CIBERehd, Hospital Clínico Universitario Virgen de la Arrixaca , Murcia , Spain.

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http://dx.doi.org/10.3389/fimmu.2017.00043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5271383PMC
January 2017

The inflammasome pathway in stable COPD and acute exacerbations.

ERJ Open Res 2016 Jul 11;2(3). Epub 2016 Jul 11.

Fundació Clinic per a la Recerca Biomèdica, Barcelona, Spain; CIBER Respiratory Diseases (CIBERES), Barcelona, Spain; Institut Respiratori, Hospital Clinic, Barcelona, Spain; Biomedic Research Institute August Pi i Sunyer (IDIBAPS), Barcelona, Spain.

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http://dx.doi.org/10.1183/23120541.00002-2016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5034597PMC
July 2016

Macrophage activation and polarization modify P2X7 receptor secretome influencing the inflammatory process.

Sci Rep 2016 Mar 3;6:22586. Epub 2016 Mar 3.

Inflammation and Experimental Surgery Unit, CIBERehd, Murcia's BioHealth Research Institute IMIB-Arrixaca, Clinical University Hospital Virgen de la Arrixaca, 30120 Murcia, Spain.

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http://dx.doi.org/10.1038/srep22586DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4776275PMC
March 2016

Purinergic signaling during macrophage differentiation results in M2 alternative activated macrophages.

J Leukoc Biol 2016 Feb 17;99(2):289-99. Epub 2015 Sep 17.

Unidad de Inflamación Molecular y Cirugía Experimental, Centro de Investigación Biomédica en Red en el Área temática de Enfermedades Hepáticas y Digestivas (CIBERehd), Instituto Murciano de Investigación Biosanitaria, Hospital Clínico Universitario Virgen de la Arrixaca (IMIB-Arrixaca), Murcia, Spain

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http://dx.doi.org/10.1189/jlb.1A0514-267RRDOI Listing
February 2016

Understanding the roles of the P2X7 receptor in solid tumour progression and therapeutic perspectives.

Biochim Biophys Acta 2015 Oct 14;1848(10 Pt B):2584-602. Epub 2014 Nov 14.

School of Biomedical Sciences, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, United Kingdom.

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http://dx.doi.org/10.1016/j.bbamem.2014.10.029DOI Listing
October 2015

Isolation of Particles of Recombinant ASC and NLRP3.

Bio Protoc 2015 May;5(10)

Inflammation and Experimental Surgery Unit, Clinical University Hospital "Virgen de la Arrixaca", Murcia, Spain.

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http://dx.doi.org/10.21769/BioProtoc.1480DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5659372PMC
May 2015

AIM2 and NLRC4 inflammasomes contribute with ASC to acute brain injury independently of NLRP3.

Proc Natl Acad Sci U S A 2015 Mar 16;112(13):4050-5. Epub 2015 Mar 16.

Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, United Kingdom; and

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http://dx.doi.org/10.1073/pnas.1419090112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4386342PMC
March 2015

Apoptosis-associated speck-like protein containing a CARD forms specks but does not activate caspase-1 in the absence of NLRP3 during macrophage swelling.

J Immunol 2015 Feb 31;194(3):1261-73. Epub 2014 Dec 31.

Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, United Kingdom; and Unidad de Inflamación y Cirugía Experimental, Centro de Investigación Biomédica en Red en el Área Temática de Enfermedades Hepáticas y Digestivas, Hospital Clínico Universitario Virgen de la Arrixaca, Instituto Murciano de Investigación Biosanitaria-Arrixaca, 30120 Murcia, Spain

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http://www.jimmunol.org/content/194/3/1261.full.pdf
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http://www.jimmunol.org/cgi/doi/10.4049/jimmunol.1301676
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http://dx.doi.org/10.4049/jimmunol.1301676DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4883655PMC
February 2015

The NLRP3 inflammasome is released as a particulate danger signal that amplifies the inflammatory response.

Nat Immunol 2014 Aug 22;15(8):738-48. Epub 2014 Jun 22.

1] Inflammation and Experimental Surgery Unit, CIBERehd, Institute for Bio-Health Research of Murcia, Clinical University Hospital Virgen de la Arrixaca, Murcia, Spain. [2] Faculty of Life Sciences, University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1038/ni.2919DOI Listing
August 2014

ATP modulates acute inflammation in vivo through dual oxidase 1-derived H2O2 production and NF-κB activation.

J Immunol 2014 Jun 19;192(12):5710-9. Epub 2014 May 19.

Departamento de Biología Celular e Histología, Facultad de Biología, Universidad de Murcia, 30100 Murcia, Spain; Instituto Murciano de Investigación Biosanitaria, 30120 Murcia, Spain; and

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http://dx.doi.org/10.4049/jimmunol.1302902DOI Listing
June 2014

P2X7 receptors mediate resistance to toxin-induced cell lysis.

Biochim Biophys Acta 2014 May 31;1843(5):915-22. Epub 2014 Jan 31.

Institute of Anatomy, University of Bern, Bern, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.bbamcr.2014.01.024DOI Listing
May 2014

P2X7 receptor activation impairs exogenous MHC class I oligopeptides presentation in antigen presenting cells.

PLoS One 2013 5;8(8):e70577. Epub 2013 Aug 5.

Unidad de Inflamación y Cirugía Experimental, Centro de Investigación Biomédica en Red en el Área temática de Enfermedades Hepáticas y Digestivas (CIBERehd), Instituto Murciano de Investigación Biosanitaria (IMIB), Hospital Universitario Virgen de la Arrixaca - Fundación Formación Investigación Sanitaria Región Murcia (FFIS), Murcia, Spain.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0070577PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3734297PMC
March 2014

The participation of plasma membrane hemichannels to purinergic signaling.

Biochim Biophys Acta 2013 Jan 12;1828(1):79-93. Epub 2012 Jan 12.

University Hospital Virgen de la Arrixaca, Fundación Formación Investigación Sanitaria Región Murcia, Murcia, Spain.

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http://dx.doi.org/10.1016/j.bbamem.2012.01.002DOI Listing
January 2013

2-methoxyestradiol in the pathophysiology of endometriosis: focus on angiogenesis and therapeutic potential.

Reprod Sci 2012 Oct 8;19(10):1018-29. Epub 2012 Aug 8.

Department of Gynecology and Obstetrics, Hospital Virgen Arrixaca, Murcia, Spain.

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http://dx.doi.org/10.1177/1933719112446080DOI Listing
October 2012

A genetically encoded IL-1β bioluminescence resonance energy transfer sensor to monitor inflammasome activity.

J Immunol 2012 Sep 18;189(5):2131-7. Epub 2012 Jul 18.

Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, United Kingdom.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3437522PMC
http://dx.doi.org/10.4049/jimmunol.1201349DOI Listing
September 2012

Cell volume regulation modulates NLRP3 inflammasome activation.

Immunity 2012 Sep 13;37(3):487-500. Epub 2012 Sep 13.

Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, UK.

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http://dx.doi.org/10.1016/j.immuni.2012.06.013DOI Listing
September 2012

Modulating P2X7 Receptor Signaling during Rheumatoid Arthritis: New Therapeutic Approaches for Bisphosphonates.

J Osteoporos 2012 8;2012:408242. Epub 2012 Jul 8.

Inflammation and Experimental Surgery Unit, CIBERehd, University Hospital "Virgen de la Arrixaca" and Foundation for Healthcare Training and Research of The Region of Murcia (FFIS), Carretera Madrid-Cartagena s/n, 30120 Murcia, Spain.

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http://dx.doi.org/10.1155/2012/408242DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3399340PMC
August 2012

P2X7 receptor-stimulation causes fever via PGE2 and IL-1β release.

FASEB J 2012 Jul 6;26(7):2951-62. Epub 2012 Apr 6.

Inflammation and Experimental Surgery Unit, Centro de Investigación Biomédica en Red de Enfermedades Hepaticas y Digestivas, University Hospital Virgen de Arrixaca-Fundación Formación Investigación Sanitaria Región Murcia, Murcia, Spain.

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http://www.fasebj.org/content/26/7/2951.full.pdf
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http://www.fasebj.org/cgi/doi/10.1096/fj.12-205765
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http://dx.doi.org/10.1096/fj.12-205765DOI Listing
July 2012

Current status of inflammasome blockers as anti-inflammatory drugs.

Expert Opin Investig Drugs 2012 Jul 22;21(7):995-1007. Epub 2012 May 22.

University of Manchester, Faculty of Life Science, AV Hill Building, 2.021, Manchester, M13 9PT, UK.

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https://www.tandfonline.com/doi/full/10.1517/13543784.2012.6
Publisher Site
http://dx.doi.org/10.1517/13543784.2012.690032DOI Listing
July 2012

Novel macrophage polarization model: from gene expression to identification of new anti-inflammatory molecules.

Cell Mol Life Sci 2011 Sep 28;68(18):3095-107. Epub 2010 Dec 28.

Faculty of Life Science, University of Manchester, Michael Smith Building D3315, Manchester, M13 9PT, UK.

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http://dx.doi.org/10.1007/s00018-010-0609-yDOI Listing
September 2011

P2X7 receptor-dependent intestinal afferent hypersensitivity in a mouse model of postinfectious irritable bowel syndrome.

J Immunol 2011 Aug 22;187(3):1467-74. Epub 2011 Jun 22.

Department of Biomedical Sciences, University of Sheffield, Sheffield S10 2TN, United Kingdom.

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http://dx.doi.org/10.4049/jimmunol.1100423DOI Listing
August 2011

Many ways to dilate the P2X7 receptor pore.

Authors:
Pablo Pelegrín

Br J Pharmacol 2011 Jul;163(5):908-11

Inflammation and Experimental Surgery Unit, University Hospital, Murcia, Spain.

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http://dx.doi.org/10.1111/j.1476-5381.2011.01325.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3130938PMC
July 2011

P2X7 receptor antagonism in the treatment of cancers.

Expert Opin Investig Drugs 2011 Jul 27;20(7):875-80. Epub 2011 May 27.

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http://dx.doi.org/10.1517/13543784.2011.583918DOI Listing
July 2011

P2X(7) receptor-mediated release of cathepsins from macrophages is a cytokine-independent mechanism potentially involved in joint diseases.

J Immunol 2010 Aug 16;185(4):2611-9. Epub 2010 Jul 16.

Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom.

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http://dx.doi.org/10.4049/jimmunol.1000436DOI Listing
August 2010

C-terminal calmodulin-binding motif differentially controls human and rat P2X7 receptor current facilitation.

J Biol Chem 2010 Jun 8;285(23):17514-24. Epub 2010 Apr 8.

Inserm U921, Université François Rabelais de Tours, 10 Boulevard Tonnellé, 37032 Tours, France.

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http://dx.doi.org/10.1074/jbc.M109.053082DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2878516PMC
June 2010

Dynamics of macrophage polarization reveal new mechanism to inhibit IL-1beta release through pyrophosphates.

EMBO J 2009 Jul 18;28(14):2114-27. Epub 2009 Jun 18.

Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, UK.

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http://dx.doi.org/10.1038/emboj.2009.163DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2699392PMC
July 2009

The P2X(7) receptor-pannexin connection to dye uptake and IL-1beta release.

Purinergic Signal 2009 Jun 12;5(2):129-37. Epub 2009 Feb 12.

Faculty of Life Science, University of Manchester, Manchester, M13 9PT, UK.

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http://dx.doi.org/10.1007/s11302-009-9141-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2686830PMC
June 2009

Pharmacological characterization of pannexin-1 currents expressed in mammalian cells.

J Pharmacol Exp Ther 2009 Feb 20;328(2):409-18. Epub 2008 Nov 20.

Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom.

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http://dx.doi.org/10.1124/jpet.108.146365DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2682283PMC
February 2009

Pannexin-1-dependent caspase-1 activation and secretion of IL-1beta is regulated by zinc.

Eur J Immunol 2009 Feb;39(2):352-8

Faculty of Life Sciences, University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1002/eji.200838843DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2696683PMC
February 2009

Targeting interleukin-1 signaling in chronic inflammation: focus on P2X(7) receptor and Pannexin-1.

Authors:
Pablo Pelegrin

Drug News Perspect 2008 Oct;21(8):424-33

Faculty of Life Science, University of Manchester, Manchester, England, U.K.

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http://dx.doi.org/10.1358/dnp.2008.21.8.1265800DOI Listing
October 2008

P2X7 receptor differentially couples to distinct release pathways for IL-1beta in mouse macrophage.

J Immunol 2008 Jun;180(11):7147-57

Faculty of Life Science, University of Manchester, Manchester, United Kingdom.

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http://dx.doi.org/10.4049/jimmunol.180.11.7147DOI Listing
June 2008

Facilitation of P2X7 receptor currents and membrane blebbing via constitutive and dynamic calmodulin binding.

J Neurosci 2008 Jun;28(25):6393-401

Faculty of Life Science, University of Manchester, Manchester M13 9PT, United Kingdom.

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http://dx.doi.org/10.1523/JNEUROSCI.0696-08.2008DOI Listing
June 2008

Molecular and functional characterization of gilthead seabream Sparus aurata caspase-1: the first identification of an inflammatory caspase in fish.

Mol Immunol 2008 Jan 3;45(1):49-57. Epub 2007 Jul 3.

Department of Cell Biology, Faculty of Biology, University of Murcia, 30100 Murcia, Spain.

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http://dx.doi.org/10.1016/j.molimm.2007.05.015DOI Listing
January 2008

Amino acid residues in the P2X7 receptor that mediate differential sensitivity to ATP and BzATP.

Mol Pharmacol 2007 Jan 10;71(1):92-100. Epub 2006 Oct 10.

Department of Biomedical Science, Addison Building Western Bank, University of Sheffield, Sheffield S10 2TN, UK.

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http://dx.doi.org/10.1124/mol.106.030163DOI Listing
January 2007

Pannexin-1 couples to maitotoxin- and nigericin-induced interleukin-1beta release through a dye uptake-independent pathway.

J Biol Chem 2007 Jan 22;282(4):2386-94. Epub 2006 Nov 22.

Department of Biomedical Science, University of Sheffield, Sheffield S10 2TN, United Kingdom.

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http://dx.doi.org/10.1074/jbc.M610351200DOI Listing
January 2007

Pannexin-1 mediates large pore formation and interleukin-1beta release by the ATP-gated P2X7 receptor.

EMBO J 2006 Nov 12;25(21):5071-82. Epub 2006 Oct 12.

Department of Biomedical Science, University of Sheffield, Sheffield, UK.

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http://dx.doi.org/10.1038/sj.emboj.7601378DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1630421PMC
November 2006

Early innate immune response and redistribution of inflammatory cells in the bony fish gilthead seabream experimentally infected with Vibrio anguillarum.

Cell Tissue Res 2005 Apr 16;320(1):61-8. Epub 2005 Feb 16.

Department of Cell Biology, Faculty of Biology, University of Murcia, Campus Universitario de Espinardo, 30100, Murcia, Spain.

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http://dx.doi.org/10.1007/s00441-004-1063-7DOI Listing
April 2005

Acidophilic granulocytes of the marine fish gilthead seabream (Sparus aurata L.) produce interleukin-1beta following infection with Vibrio anguillarum.

Cell Tissue Res 2004 May 25;316(2):189-95. Epub 2004 Mar 25.

Department of Cell Biology, Faculty of Biology, University of Murcia, Campus Universitario de Espinardo, 30100 Murcia, Spain.

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http://dx.doi.org/10.1007/s00441-004-0875-9DOI Listing
May 2004

Production and mechanism of secretion of interleukin-1beta from the marine fish gilthead seabream.

Dev Comp Immunol 2004 Mar;28(3):229-37

Department of Cell Biology, Faculty of Biology, University of Murcia, Campus Universitario de Espinardo, 30100, Murcia, Spain

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March 2004

Molecular cloning and expression analysis of tumor necrosis factor alpha from a marine fish reveal its constitutive expression and ubiquitous nature.

Immunogenetics 2002 Jun 17;54(3):200-7. Epub 2002 Apr 17.

Department of Cell Biology, Faculty of Biology, University of Murcia, 30100 Murcia, Spain.

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http://dx.doi.org/10.1007/s00251-002-0451-yDOI Listing
June 2002