Publications by authors named "P Qiu"

965 Publications

Circular polarization analyzer based on surface plasmon polariton interference.

Opt Express 2021 Nov;29(23):37907-37916

The determination of chirality of circularly polarized light (CPL) is of great significance to the development of various optical techniques. In this paper, a miniature circular polarization analyzer (CPA) based on surface plasmon polariton (SPP) interference is proposed. The proposed CPA consists of a micron scale long sub-wavelength slit and two groups of spatially arranged periodic sub-wavelength rectangular groove pairs, which are etched in a metal layer. Under the illumination of a CPL with a given chirality, the proposed CPA is capable of forming SPP-mediated interference fringes with different periods in far field. The chirality of CPL can be directly and quantitatively differentiated by the frequency value of the far field SPP-mediated interference fringes. Different from the existing SPP-based CPAs, the proposed CPA can directly image the chirality information in far field, avoiding near-field imaging of the SPP field.
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http://dx.doi.org/10.1364/OE.442630DOI Listing
November 2021

Hsa-mir-3163 and CCNB1 may be potential biomarkers and therapeutic targets for androgen receptor positive triple-negative breast cancer.

PLoS One 2021 19;16(11):e0254283. Epub 2021 Nov 19.

Thyroid & Breast Surgery, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, China.

Breast cancer (BC) is the most common malignancy in female, but the role of androgen receptor (AR) in triple-negative breast cancer (TNBC) is still unclear. This study aimed to exam the performance of innovative biomarkers for AR positive TNBC in diagnosis and therapies. Four datasets (GSE42568, GSE45827, GSE54002 and GSE76124) were analyzed by bioinformatic methods and the differential expression genes (DEGs) between the AR positive TNBC tissues and normal tissues were firstly identified by limma package and Venn diagrams. Next, Gene Ontologies (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis were performed to explore the relationship between these DEGs. Then, the Protein-protein interaction (PPI) network was constructed. CytoHubba and bioinformatic approaches including Molecular Complex Detection (MCODE), Gene Expression Profiling Interactive Analysis (GEPIA), the Kaplan-Meier (KM) plotter and The Human Pro-tein Atlas (THPA) were used to identify the hub genes. Lastly, a miRNA-hub-gene regulatory axis was constructed by use of Target Scan database and ENCORI database. As a result, a total of 390 common DEGs were identified, including 250 up-regulated and 140 down-regulated. GO and KEGG enrichment analysis showed that the up-regulated DEGs were mostly enriched in the cell division, mitotic nuclear division, nucleosome, midbody, protein heterodimerization activity, cadherin binding involved in cell-cell adhesion, systemic lupus erythematosus and alcoholism, while the down-regulated DEGs were mainly enriched in carbohydrate metabolic process, extracellular space, extracellular region, zinc ion binding and microRNAs in cancer. Then, 13 hub genes (CCNB2, FOXM1, HMMR, MAD2L1, RRM2, TPX2, TYMS, CEP55, AURKA, CCNB1, CDK1, TOP2A, PBK) were selected. The survival analysis revealed that only CCNB1 was associated with significantly poor survival (P <0.05) in TNBC patients. Finally, we found that hsa-miR-3163 took part in the regulation of CCNB1 and constructed a potential hsa-miR-3163-CCNB1 regulatory axis. The results of current study suggest that CCNB1 and hsa-miR-3163 may serve as highly potential prognostic markers and therapeutic targets for AR positive TNBC. Our findings may make contributions to the diagnosis and therapies of AR positive TNBC.
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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0254283PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8604295PMC
November 2021

A Meta-Analysis of Randomized Controlled Trials on Therapeutic Efficacy and Safety of Autologous Cell Therapy for Atherosclerosis Obliterans.

J Vasc Surg 2021 Nov 14. Epub 2021 Nov 14.

Department of Vascular Surgery, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai 200000, China. Electronic address:

Background: Atherosclerosis obliterans (ASO) is a chronic occlusive arterial disease and the most common type of peripheral arterial disease. Current treatment options like medication and vascularization have limited effects for "no-option" patients, and stem cell therapy is considered a viable option although its application and efficacy have not been standardized. The objective of this review was to assess the safety and efficacy of autologous stem cell therapy in patients with ASO.

Methods: We performed a literature search of published RCTs for ASO patients receiving stem cell therapy without a revascularization option. PubMed, Embase, and the Cochrane Library were searched. This study was conducted by a pair of authors independently and audited by a third author. Data were synthesized with a random-effect model.

Results: 630 patients in 12 RCTs were included. The results showed that cell therapy significantly improved total amputation (RR: 0.64, p = 0.004, 95% CI: [0.47, 0.87]), major amputation (RR: 0.69, p = 0.02, 95% CI: [0.50, 0.94]), ankle-brachial index (ABI) (MD = 0.08, p = 0.004, 95% CI: [0.02, 0.13]), transcutaneous oxygen tension (TcO) (MD = 11.52, p = 0.004, 95% CI: [3.60, 19.43]) and rest pain score (MD = -0.64, p = 0.007, 95% CI: [-1.10, -0.17]) compared to placebo or standard care. However, current studies showed cell therapy was not superior to placebo or standard care in all-cause death (RR: 0.75, p = 0.34, 95% CI: [0.41, 1.36]) and ulcer size (MD = -8.85, p = 0.39, CI: [-29.05,11.36]).

Limitation: The number of trials included was limited. Moreover, most trials were designed for "no-option" patients and thus the results should be applied with caution to other PAD patients.

Conclusion: ASO patients can benefit from autologous cell therapy in limb salvage, limb blood perfusion, and rest pain alleviation.
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http://dx.doi.org/10.1016/j.jvs.2021.10.051DOI Listing
November 2021

Non-parametric treatment time-lag effect estimation.

Stat Methods Med Res 2021 Nov 16:9622802211032693. Epub 2021 Nov 16.

Department of Biostatistics, University of Florida, Gainesville, FL, USA.

In general, the change point problem considers inference of a change in distribution for a set of time-ordered observations. This has applications in a large variety of fields, and can also apply to survival data. In survival analysis, most existing methods compare two treatment groups for the entirety of the study period. Some treatments may take a length of time to show effects in subjects. This has been called the time-lag effect in the literature, and in cases where time-lag effect is considerable, such methods may not be appropriate to detect significant differences between two groups. In this paper, we propose a novel non-parametric approach for estimating the point of treatment time-lag effect by using an empirical divergence measure. Theoretical properties of the estimator are studied. The results from the simulated data and the applications to real data examples support our proposed method.
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http://dx.doi.org/10.1177/09622802211032693DOI Listing
November 2021

New Steroidal Saponins Isolated from the Rhizomes of .

Molecules 2021 Oct 21;26(21). Epub 2021 Oct 21.

Department of Pharmaceutics, School of Pharmacy, Air Force Medical University, Xi'an 710032, China.

The genus is an excellent source of steroidal saponins that exhibit various bioactivities. is a unique species and has been widely used as folk medicine in Southwest China for a long time. With the help of chemical methods and modern spectra analysis, five new steroidal saponins, pamaiosides A-E (-), along with five known steroidal saponins -, were isolated from the rhizomes of . The cytotoxicity of all the new saponins was evaluated against human pancreatic adenocarcinoma PANC-1 and BxPC3 cell lines.
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http://dx.doi.org/10.3390/molecules26216366DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8588014PMC
October 2021
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