Publications by authors named "P Moghetti"

118 Publications

Accuracy of CGM Systems During Continuous and Interval Exercise in Adults with Type 1 Diabetes.

J Diabetes Sci Technol 2021 Jun 11:19322968211023522. Epub 2021 Jun 11.

Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, University and Hospital of Verona, Verona, Italy.

Background: continuous glucose monitoring systems (CGMs) play an important role in the management of T1D, but their accuracy may reduce during rapid glucose excursions. The aim of study was to assess the accuracy of recent rt-CGMs available in Italy, in subjects with T1D during 2 sessions of physical activity: moderate continuous (CON) and interval exercise (IE).

Method: we recruited 22 patients with T1D, on CSII associated or integrated with a CGM, to which a second different sensor was applied. Data recorded by CGMs were compared with the corresponding plasma glucose (PG) values, measured every 5 minutes with the glucose analyzer. To assess the accuracy of the CGMs, we evaluated the Sensor Bias (SB), the Mean Absolute Relative Difference (MARD) and the Clarke error grid (CEG).

Results: a total of 2355 plasma-sensor glucose paired points were collected. Both average plasma and interstitial glucose concentrations did not significantly differ during CON and IE. During CON: 1. PG change at the end of exercise was greater than during IE ( = .034); 2. all sensors overestimated PG more than during IE, as shown by SB ( < .001) and MARD ( < .001) comparisons. Classifying the performance according to the CEG, significant differences were found between the 2 sessions in distribution of points in A and B zones.

Conclusions: the exercise affects the accuracy of currently available CGMs, especially during CON, suggesting, in this circumstance, the need to maintain blood glucose in a "prudent" range, above that generally recommended. Further studies are needed to investigate additional types of activities.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1177/19322968211023522DOI Listing
June 2021

Insulin-Mediated Substrate Utilization in Women with the Different Phenotypes of PCOS: Role of Androgens.

J Clin Endocrinol Metab 2021 May 29. Epub 2021 May 29.

Endocrinology, Diabetes and Metabolism, University of Verona and Azienda Ospedaliera Universitaria Integrata Verona, Verona, Italy.

Context/objective: Few studies have explored in vivo insulin action on substrate utilization in women with PCOS. In particular, no data are available in women with different PCOS phenotypes. The aim of the study was to evaluate insulin action on glucose (Gox) and lipid (Lox) oxidation, non-oxidative glucose metabolism (Gnonox), and serum free fatty acid (FFA) in different PCOS phenotypes.

Subjects: One hundred and eighty-seven non-diabetic women with PCOS, diagnosed according to the Rotterdam criteria. Data from a historical sample of 20 healthy women were used as reference values.

Design: Whole body substrate utilization data were obtained by the hyperinsulinemic euglycemic clamp associated with indirect calorimetry. Serum androgens were assessed by liquid chromatography-mass spectrometry and equilibrium dialysis.

Results: During hyperinsulinemia, the increase of Gox (Δ Gox), Gnonox, as well as the suppression of Lox (Δ Lox) and serum FFA (Δ% FFA) were altered in each PCOS phenotype. Moreover, Gnonox and Δ% FFA were lower in women with the classic phenotype than in those with the ovulatory or the normoandrogenic phenotypes, and Δ Gox was lower in women with the classic than in those with the ovulatory phenotype. In multivariate analysis fat mass and free testosterone were independent predictors of Δ Gox, Gnonox and Δ% FFA, whereas only fat mass predicted Δ Lox.

Conclusions: In women with PCOS, regardless of their phenotypes, insulin-mediated substrate utilization is impaired. This phenomenon is greater in subjects with the classic phenotype. Free testosterone plays an independent role on insulin action abnormalities on glucose and lipid metabolism.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1210/clinem/dgab380DOI Listing
May 2021

Onset of Addison Disease appeared during the first trimester of a twin pregnancy: A case report.

Clin Case Rep 2021 May 5;9(5):e03784. Epub 2021 May 5.

Department of Medicine Section of General Medicine and Hypertension University of Verona Verona Italy.

Addison Disease is an uncommon, life-threatening condition affecting people at any age, including women during pregnancy. If left untreated, the disease can be rapidly fatal, but the prognosis is good if promptly recognized and hormones are replaced.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1002/ccr3.3784DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8117816PMC
May 2021

Walking for subjects with type 2 diabetes: A systematic review and joint AMD/SID/SISMES evidence-based practical guideline.

Nutr Metab Cardiovasc Dis 2020 10 2;30(11):1882-1898. Epub 2020 Sep 2.

Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy.

Aims: Regular exercise is considered a cornerstone in the management of type 2 diabetes mellitus (T2DM). It improves glucose control and cardiovascular risk factors, contributes to weight loss, and also improves general well-being, likely playing a role in the prevention of chronic complications of diabetes. However, compliance to exercise recommendations is generally inadequate in subjects with T2DM. Walking is the most ancestral form of physical activity in humans, easily applicable in daily life. It may represent, in many patients, a first simple step towards lifestyle changes. Nevertheless, while most diabetic patients do not engage in any weekly walking, exercise guidelines do not generally detail how to improve its use. The aims of this document are to conduct a systematic review of available literature on walking as a therapeutic tool for people with T2DM, and to provide practical, evidence-based clinical recommendations regarding its utilization in these subjects.

Data Synthesis: Analysis of available RCTs proved that regular walking training, especially when supervised, improves glucose control in subjects with T2DM, with favorable effects also on cardiorespiratory fitness, body weight and blood pressure. Moreover, some recent studies have shown that even short bouts of walking, used for breaking prolonged sitting, can ameliorate glucose profiles in diabetic patients with sedentary behavior.

Conclusions: There is sufficient evidence to recognize that walking is a useful therapeutic tool for people with T2DM. This document discusses theoretical and practical issues for improving its use. This article is co-published in the journals Sport Sciences for Health and Nutrition, Metabolism and Cardiovascular Diseases.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.numecd.2020.08.021DOI Listing
October 2020
-->