Publications by authors named "P Hall"

2,305 Publications

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The Finding My Way UK Clinical Trial: Adaptation Report and Protocol for a Replication Randomized Controlled Efficacy Trial of a Web-Based Psychological Program to Support Cancer Survivors.

JMIR Res Protoc 2021 Sep 20;10(9):e31976. Epub 2021 Sep 20.

College of Education, Psychology & Social Work, Flinders University, Adelaide, Australia.

Background: Cancer survivors frequently report a range of unmet psychological and supportive care needs; these often continue after treatment has finished and are predictive of psychological distress and poor health-related quality of life. Web-based interventions demonstrate good efficacy in addressing these concerns and are more accessible than face-to-face interventions. Finding My Way (FMW) is a web-based, psycho-educational, and cognitive behavioral therapy intervention for cancer survivors developed in Australia. Previous trials have demonstrated that FMW is acceptable, highly adhered to, and effective in reducing the impact of distress on quality of life while leading to cost savings through health resource use reduction.

Objective: This study aims to adapt the Australian FMW website for a UK cancer care context and then undertake a single-blinded, randomized controlled trial of FMW UK against a treatment-as-usual waitlist control.

Methods: To an extent, our trial design replicates the existing Australian randomized controlled trial of FMW. Following a comprehensive adaptation of the web resource, we will recruit 294 participants (147 per study arm) from across clinical sites in North West England and North Wales. Participants will have been diagnosed with cancer of any type in the last 6 months, have received anticancer treatment with curative intent, be aged ≥16 years, be proficient in English, and have access to the internet and an active email address. Participants will be identified and recruited through the National Institute for Health Research clinical research network. Measures of distress, quality of life, and health economic outcomes will be collected using a self-report web-based questionnaire at baseline, midtreatment, posttreatment, and both 3- and 6-month follow-up. Quantitative data will be analyzed using intention-to-treat mixed model repeated measures analysis. Embedded semistructured qualitative interviews will probe engagement with, and experiences of using, FMW UK and suggestions for future improvements.

Results: The website adaptation work was completed in January 2021. A panel of cancer survivors and health care professionals provided feedback on the test version of FMW UK. Feedback was positive overall, although minor updates were made to website navigation, inclusivity, terminology, and the wording of the Improving Communication and Sexuality and Intimacy content. Recruitment for the clinical trial commenced in April 2021. We aim to report on findings from mid-2023.

Conclusions: Replication studies are an important aspect of the scientific process, particularly in psychological and clinical trial literature, especially in different geographical settings. Before replicating the FMW trial in the UK setting, content updating was required. If FMW UK now replicates Australian findings, we will have identified a novel and cost-effective method of psychosocial care delivery for cancer survivors in the United Kingdom.

Trial Registration: International Standard Randomized Controlled Trial Number (ISRCTN) 14317248; https://www.isrctn.com/ISRCTN14317248.

International Registered Report Identifier (irrid): DERR1-10.2196/31976.
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http://dx.doi.org/10.2196/31976DOI Listing
September 2021

Tetraspanin CD53 modulates lymphocyte trafficking but not systemic autoimmunity in Lyn-deficient mice.

Immunol Cell Biol 2021 Sep 12. Epub 2021 Sep 12.

Centre for Inflammatory Diseases, Monash University, Department of Medicine, Monash Medical Centre, 246 Clayton Rd, Clayton, VIC, Australia.

The leukocyte-restricted tetraspanin CD53 has been shown to promote lymphocyte homing to lymph nodes and myeloid cell recruitment to acutely inflamed peripheral organs, and accelerate the onset of immune-mediated disease. However, its contribution in the setting of chronic systemic autoimmunity has not been investigated. We made use of the Lyn autoimmune model, generating Cd53 Lyn mice, and compared trafficking of immune cells into secondary lymphoid organs and systemic autoimmune disease development with mice lacking either gene alone. Consistent with previous observations, absence of CD53 led to reduced lymph node cellularity via reductions in both B and T cells, a phenotype also observed in Cd53 Lyn mice. In some settings, Cd53 Lyn lymphocytes showed greater loss of surface L-selectin and CD69 upregulation above that imparted by Lyn deficiency alone, indicating that absence of these two proteins can mediate additive effects in the immune system. Conversely, prototypical effects of Lyn deficiency including splenomegaly, plasma cell expansion, elevated serum IgM and anti-nuclear antibodies were unaffected by CD53 deficiency. Furthermore, while Lyn mice developed glomerular injury and showed elevated glomerular neutrophil retention above than that in wild-type mice, absence of CD53 in Lyn mice did not alter these responses. Together these findings demonstrate that while tetraspanin CD53 promotes lymphocyte trafficking into lymph nodes independent of Lyn, it does not make an important contribution to development of autoimmunity, plasma cell dysfunction or glomerular injury in the Lyn model of systemic autoimmunity.
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http://dx.doi.org/10.1111/imcb.12501DOI Listing
September 2021

[It is time for individual breast cancer prevention].

Lakartidningen 2021 Sep 3;118. Epub 2021 Sep 3.

verksamhetchef, överläkare, Bröst-cent-rum, Södersjukhuset, Stockholm.

Breast cancer prevention must include interventions aiming at both reducing the risk of breast cancer (primary prevention) and identifying cancers at an early stage (secondary prevention). Sweden has one of the best breast cancer screening programs globally, but women are still screened without taking risk of breast cancer or difficulties diagnosing a cancer into consideration. Today it is possible to identify women at high risk of breast cancer and those women that have high mammographic density. These women should be offered individualised screening.  Women at very high risk of breast cancer should be offered primary preventive initiatives.
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September 2021

Morphology of the Prefrontal Cortex Predicts Body Composition in Early Adolescence: Cognitive Mediators and Environmental Moderators in the ABCD Study.

Soc Cogn Affect Neurosci 2021 Sep 2. Epub 2021 Sep 2.

Department of Psychology, University of Waterloo, Canada.

Morphological features of the lateral prefrontal cortex (PFC) in late childhood and early adolescence may provide important clues as to the developmental etiology of clinical conditions such as obesity. Body composition measurements and structural brain imaging were performed on 11,226 youth at baseline (age 9 or 10) and follow-up (age 11 or 12). Baseline morphological features of the lateral PFC were examined as predictors of body composition. Findings revealed reliable associations between mid-frontal gyrus volume, thickness and surface area and multiple indices of body composition. These findings were consistent across both time points, and remained significant after covariate adjustment. Cortical thickness of the inferior frontal gyrus and lateral orbitofrontal cortex were also reliable predictors. Morphology effects on body composition were mediated by performance on a non-verbal reasoning task. Modest but reliable moderation effects were observed with respect to environmental self-regulatory demand after controlling for sex, race/ethnicity, income and methodological variables. Overall findings suggest that prefrontal cortex morphology is a reliable predictor of body composition in early adolescence, as mediated through select cognitive functions and partially moderated by environmental characteristics.
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http://dx.doi.org/10.1093/scan/nsab104DOI Listing
September 2021
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