Publications by authors named "P Šrenk"

8 Publications

Clinical Presentation, Diagnostic Findings, and Long-term Survival Time in 182 Dogs With Meningoencephalitis of Unknown Origin From Central Europe That Were Administered Glucocorticosteroid Monotherapy.

Top Companion Anim Med 2021 May 5;44:100539. Epub 2021 May 5.

Institute of Mathematics and Statistics, Masaryk University, Brno, 60200 Czech Republic.

Canine non-infectious inflammatory meningoencephalomyelitis is termed meningoencephalomyelitis of unknown origin (MUO) and may affect dogs of every breed at any age. Treatment with immunosuppressive medication, the survival time based on MRI, and cerebrospinal fluid (CSF) findings has been widely reported; however, these studies only included a small number of patients, or they are summaries from the literature. Therefore, the aim of this study was to compare the clinical presentation, diagnostic findings, treatment protocol and long-term survival time in many dogs diagnosed with MUO in one clinic with previously published studies. One hundred eighty-two dogs met the inclusion criteria. Age, sex, duration of clinical signs before diagnosis, presence of neurological signs, MRI and CSF analysis were similar to those in previous reports. Our study revealed that dogs with a brainstem lesion have a 60% lower chance of death before 1 year than dogs with multifocal brain lesions. A total of 55.56% of treated dogs survived for more than 1 year, and 10.55% survived for more than 5 years since diagnosis. The median survival time for all dogs was 540 days. Our findings support glucocorticosteroid monotherapy as a viable treatment option for dogs with MUO.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.tcam.2021.100539DOI Listing
May 2021

Stabilisation of atlantoaxial subluxation in the dog through ventral arthrodesis.

Schweiz Arch Tierheilkd 2008 Feb;150(2):69-76

Referral Small Animal Clinic JAGGY, Brno, Czech Republic.

Ten miniature breed dogs with atlantoaxial subluxation underwent ventral lag screw stabilisation. The procedure did not include bone graft packing into the atlantoaxial articulation. Four dogs showed continuous improvement after surgery. Three dogs developed complications due to external trauma and postoperative implant failure but improved with conservative therapy. Three patients died or were euthanized in early perioperative or postoperative period. The long-term outcome was good or favourable in all surviving patients. Suspected fibrous tissue proliferation and stabilisation without permanent bone fusion was found to be clinically satisfactory when the atlantoaxial joint has been subjected to limited stress during a long-term monitoring period.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1024/0036-7281.150.2.69DOI Listing
February 2008

[Cerebellar cortical abiotrophy in American Staffordshire terriers: clinical and pathological description of 3 cases].

Schweiz Arch Tierheilkd 2003 Aug;145(8):369-75

Institut für Genetik und Ernährung, Universität Bern, Brno, CZ.

Three American Staffordshire Terriers were presented with gait abnormalities and loss of balance at the age of 4.5 (female) and 6 years (2 males). The onset varied between 3 and 5 years of age and the clinical signs were slowly progressive. The neurological examination revealed symmetrical generalized cerebellar ataxia with hypermetria, stiffness, and loss of balance with no evidence of paresis. The menace reflex was decreased in one dog and absent in another. A positional nystagmus was found in two dogs. The dogs were euthanized and a histopathological examination of each brain was performed. Pathological changes were confined to the cerebellum. The main finding was loss of Purkinje cells, as well as depletion of granular cell bodies and shrinkage of the granular and molecular cell layer. These findings are consistent with cerebellar cortical abiotrophy. A genetic basis is supposed, but the mode of inheritance is not determined yet. In contrast to some spinocerebellar ataxias in humans, the cause of Purkinje cell degeneration in cerebellar cortical abiotrophy of dogs is not known.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1024/0036-7281.145.8.369DOI Listing
August 2003

Further contributions to the genetic aspect of congenital sensorineural deafness in Dalmatians.

Vet J 2002 May;163(3):311-8

Department for Clinical Veterinary Medicine, Section of Neurology, Institute of Animal Genetics, Nutrition and Housing, University of Berne, Switzerland.

Sensorineural deafness is a common congenital disorder in Dalmatians and is genetically transmitted. Different modes of inheritance have been proposed and the objective of this study was to study these by segregation analyses using maximum likelihood procedures. Data from 33 complete Dalmatian families were collected and data from 56 single Dalmatians added. This resulted in a total of 575 dogs with 357 known phenotypes. All dogs were clinically evaluated and electrophysiologically tested with brainstem auditory evoked responses. The prevalence of deafness was 16.5% (9.4% unilaterally deaf, 7.1% bilaterally deaf). Females were 4.4% more affected than males but this difference was not significant. Within the same litter, different phenotypic expressions of deafness occurred, which suggested different expressions of the disease. In addition, two data sets were analysed: the first included normal, uni- and bilaterally deaf dogs, the second had normal and deaf Dalmatians. We found that a recessive allele at a single biallelic major locus fitted our data best, although an incomplete penetrance of the recessive homozygotes was observed.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1053/tvjl.2001.0661DOI Listing
May 2002

[Hypothyroid-associated gait abnormalities in the dog].

Schweiz Arch Tierheilkd 2000 May;142(5):251-6

Institut für Tierneurologie der Universität Bern.

View Article and Find Full Text PDF

Download full-text PDF

Source
May 2000