Publications by authors named "Ozlem Ozcan Celebi"

49 Publications

Selvester score predicts implantable cardioverter defibrillator shocks in patients with non-ischemic cardiomyopathy.

J Arrhythm 2021 Aug 7;37(4):1046-1051. Epub 2021 Jun 7.

Department of Cardiology University of Health Science Ankara City Hospital Ankara Turkey.

Background: The implantable cardiac defibrillator is the cornerstone of prevention of sudden cardiac death in non-ischemic cardiomyopathy. The Selvester score, which is frequently investigated in ischemic cardiomyopathy, has not been investigated in the field of non-ischemic cardiomyopathy.

Aim: The aim of this study was to evaluate the Selvester score for determining appropriate implantable cardiac defibrillator shocks in non-ischemic cardiomyopathy patients.

Materials And Methods: In all, 131 non-ischemic cardiomyopathy patients were included in the study. A simplified Selvester score was calculated from ECG data. Patients were divided into two groups according to whether they received ICD shock.

Results: Of the patients, 28.2% received appropriate implantable cardiac defibrillator shock. The Selvester score was significantly higher in patients receiving appropriate shock when compared to patients with no implantable cardiac defibrillator shocks (8.8 ± 4.6 vs 7.2 ± 3.3,  = .040). The median QRS duration was significantly longer in patients receiving appropriate shock than in patients with no shocks (130.14 ± 35.08 ms vs 120.12 ± 20.57 ms,  = .045). We determined that the cutoff value for the Selvester score to predict ICD shocks was 6.5 with a sensitivity of 72.0% and a specificity of 83% (AUC = 0.717; %95 GA: 0.627-0.807,  < .001).

Conclusion: Selvester score was higher in patients receiving appropriate shock than in patients who did not receive any implantable cardiac defibrillator shock. From this study, the Selvester score is associated with the risk of ventricular tachycardia/ventricular fibrillation in non-ischemic cardiomyopathy so that careful attention is necessary to manage the patients with high Selvester score.
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http://dx.doi.org/10.1002/joa3.12571DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8339102PMC
August 2021

Appraisal of transthoracic echocardiography for opportunistic screening of abdominal aortic aneurysm.

Medicine (Baltimore) 2021 Jun;100(22):e26171

Department of Cardiology, TOBB Economics and Technology University Medical School, Ankara, Turkey.

Abstract: Abdominal aortic aneurysm is a life threatening disease. Most of the patients diagnosed incidentally because of the asymptomatic nature of this disease. This study aimed to determine the frequency of abdominal aortic aneurysm and evaluate the value of opportunistic screening during transthoracic echocardiography.A total of 5138 patients referred for echocardiographic evaluation for any reason were screened for abdominal aortic aneurysm between November 2014 to July 2019. The aneurysm was defined as an abdominal aorta with a diameter greater than 30 mm, or segmental dilatation of more than 50% of its size in non-dilated parts.The overall frequency of abdominal aortic aneurysm was 2.2% (n = 109) in the study population. Male sex (P < .001), older age (P < .001), presence of diastolic dysfunction (P = .036), hypertension (P < .001), coronary artery disease (P < .001), and hyperlipidemia (P < .001) were associated with abdominal aortic aneurysm. Patients with aneurysm had significantly increased diameters of the aortic trunk (P < .001) and ascending aorta (P < .001), significantly thicker interventricular septum (P < .001) and posterior wall (P < .001), significantly increased end-diastolic diameter (P < .001) and enlarged left atrium (P < .001), and significantly decreased ejection fraction (P < .001). The mostly met criteria for screening abdominal aortic aneurysm in international guidelines was the age of the patients.Based on the results of this study, screening patients over 60 years of age who undergo a transthoracic echocardiography for any reason would be beneficial to detect an asymptomatic abdominal aortic aneurysm in Turkish population.
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http://dx.doi.org/10.1097/MD.0000000000026171DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8183806PMC
June 2021

The Diagnostic Accuracy of the Instantaneous Wave-Free Ratio.

Angiology 2021 08 5;72(7):693. Epub 2021 Apr 5.

Department of Cardiology, 64241University of Health Sciences, Ankara City Hospital, Turkey.

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http://dx.doi.org/10.1177/00033197211006975DOI Listing
August 2021

An extremely rare coronary artery anomaly: Monster left anterior descending coronary artery.

Anatol J Cardiol 2021 Jan;25(1):E1-E2

Department of Cardiology, Faculty of Medicine, University of Health Sciences; Ankara-Turkey.

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http://dx.doi.org/10.14744/AnatolJCardiol.2020.68782DOI Listing
January 2021

Clinical characteristics and in-hospital outcomes of acute decompensated heart failure patients with and without atrial fibrillation.

Anatol J Cardiol 2020 04;23(5):260-267

Department of Cardiology, Faculty of Medicine, Ege University; İzmir-Turkey.

Objective: Atrial fibrillation (AF) and heart failure (HF) are common cardiovascular diseases. The impact of AF on in-hospital outcomes in acute decompensated heart failure (ADHF) is controversial. The aim of this study is to determine the prevalence of AF among hospitalized patients with ADHF and describe the clinical characteristics and in-hospital outcomes of these patients with and without AF.

Methods: We examined the multicenter, observational data from the real-life data of hospitalized patients with HF: Journey HF-TR study in Turkey that studied the clinical characteristics and in-hospital outcomes of hospitalized patients with ADHF between September 2015 and September 2016.

Results: Of the 1,606 patients hospitalized with ADHF, 626 (39%) had a history of AF or developed new-onset AF during hospitalization. The patients with AF were older (71±12 vs. 65±13 years; p<0.001) and more likely to have a history of hypertension, valvular heart disease, and stroke. The AF patients were less likely to have coronary artery disease and diabetes. In-hospital adverse event rates and length of in-hospital stay were similar in ADHF patients, both with and without AF. In-hospital all-cause mortality rate was higher in patients with AF than in patients without AF, although the difference was not statistically significant (8.9% vs. 6.8%; p=0.121).

Conclusion: AF has been found in more than one-third of the patients hospitalized with ADHF, and it has varied clinical features and comorbidities. The presence of AF is not associated with increased adverse events or all-cause mortality during the hospitalization time.
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http://dx.doi.org/10.14744/AnatolJCardiol.2020.94884DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7219303PMC
April 2020

Egg Consumption and Cardiovascular Health: How Many Eggs a Day Keep the Doctor Away?

Angiology 2020 08 6;71(7):667. Epub 2020 Apr 6.

Department of Cardiology, Ankara City Hospital, Ankara, Turkey.

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http://dx.doi.org/10.1177/0003319720916293DOI Listing
August 2020

The association between the fibrinogen-to-albumin ratio and coronary artery disease severity in patients with stable coronary artery disease.

Coron Artery Dis 2020 09;31(6):512-517

Department of Cardiology, TOBB Economics and Technology University Medical School.

Objective: Fibrinogen-to-albumin ratio (FAR) is an inexpensive and easily measurable novel inflammatory index that has been found to be associated with atherosclerosis. In this study, we aimed to investigate the association between the FAR and coronary artery disease (CAD) severity in patients with stable CAD.

Methods: In total, 356 consecutive patients with CAD were classified into three groups, those with a low Synergy between percutaneous coronary intervention and the Taxus and Cardiac Surgery Study (SYNTAX) score (≤22), those with an intermediate SYNTAX score (23≥ SYNTAX score ≤32) and those with a high SYNTAX score (>32).

Results: We determined that there were significant differences in the mean age (P < 0.001), male gender (P = 0.008), serum fibrinogen (P = 0.03), low-density lipoprotein cholesterol (P < 0.001) and FAR (P < 0.001) among the SYNTAX score groups. A strong positive correlation was detected between FAR and SYNTAX score (r = 0.899; P < 0.001), and the cutoff level of FAR for high SYNTAX score was 82 (sensitivity of 82%, specificity of 88.3% and an area under the curve of 0.826).

Conclusion: The novel inflammatory index, FAR, is significantly associated with the severity of CAD in patients with stable CAD.
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http://dx.doi.org/10.1097/MCA.0000000000000868DOI Listing
September 2020

Screening of lower extremity artery disease.

Vascular 2020 06 3;28(3):329-330. Epub 2020 Feb 3.

Department of Cardiology, TOBB Economics and Technology University Medical School, Ankara, Turkey.

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http://dx.doi.org/10.1177/1708538120902295DOI Listing
June 2020

Blood Group Types O and Non-O Are Associated With Coronary Collateral Circulation Development.

Clin Appl Thromb Hemost 2020 Jan-Dec;26:1076029619900544

Department of Cardiology, TOBB Economics and Technology University Medical School, Ankara, Turkey.

Blood group types are associated with coronary artery disease. However, data are scarce about the impact of blood group types on coronary collateral circulation. In this study, we aimed to investigate the relationship between the blood group types and coronary collateral circulation. Two hundred and twelve patients who underwent coronary angiography in our department and had a stenosis of ≥ 90% in at least one major epicardial vessel were included in our study. Collateral degree was graded according to Rentrop-Cohen classification. After grading, patients were divided into poor coronary collateral circulation (Rentrop grade 0 and 1) and good coronary collateral circulation (Rentrop 2 and 3) groups. The ABO blood type of all participants was determined. The incidence rates of O blood group type were significantly higher in the good coronary collateral group compared to the poor collateral group (37.9% vs 17.1%, < .001). The O type blood group was an independent predictor of good coronary collateral circulation (odds ratio = 1.83, 95% confidence interval = 1.56-6.18, = .015). Coronary collateral circulation is associated with blood group types. The O blood group predicts good coronary collateral development among patients with coronary artery disease.
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http://dx.doi.org/10.1177/1076029619900544DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7098203PMC
July 2020

The Usefulness of Admission Plasma NT-pro BNP Level to Predict Left Ventricular Aneurysm Formation after Acute ST-Segment Elevation Myocardial Infarction.

Arq Bras Cardiol 2019 12;113(6):1129-1137

University of Health Science, Turkiye Yuksek Ihtisas Training and Research Hospital - Cardiology, Ankara - Turkey.

Background: Left ventricular aneurysm (LVA) is an important complication of acute myocardial infarction. In this study, we investigated the role of N- Terminal pro B type natriuretic peptide level to predict the LVA development after acute ST-segment elevation myocardial infarction (STEMI).

Methods: We prospectively enrolled 1519 consecutive patients with STEMI. Patients were divided into two groups according to LVA development within the six months after index myocardial infarction. Patients with or without LVAs were examined to determine if a significant relationship existed between the baseline N- Terminal pro B type natriuretic peptide values and clinical characteristics. A p-value < 0.05 was considered statistically significant.

Results: LVA was detected in 157 patients (10.3%). The baseline N- Terminal pro- B type natriuretic peptide level was significantly higher in patients who developed LVA after acute MI (523.5 ± 231.1 pg/mL vs. 192.3 ± 176.6 pg/mL, respectively, p < 0.001). Independent predictors of LVA formation after acute myocardial infarction was age > 65 y, smoking, Killip class > 2, previous coronary artery bypass graft, post-myocardial infarction heart failure, left ventricular ejection fraction < 50%, failure of reperfusion, no-reflow phenomenon, peak troponin I and CK-MB and NT-pro BNP > 400 pg/mL at admission.

Conclusions: Our findings indicate that plasma N- Terminal pro B type natriuretic peptide level at admission among other variables provides valuable predictive information regarding the development of LVA after acute STEMI.
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http://dx.doi.org/10.5935/abc.20190226DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7021256PMC
December 2019

Atrial fibrillation and health-related quality of life.

Pacing Clin Electrophysiol 2020 01 31;43(1):156. Epub 2019 Oct 31.

Department of Cardiology, Ankara City Hospital, Ankara, Turkey.

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http://dx.doi.org/10.1111/pace.13821DOI Listing
January 2020

Invasive screening for lower extremity peripheral artery disease: Killing two birds with one stone?

Vascular 2020 04 11;28(2):196-202. Epub 2019 Oct 11.

Department of Cardiology, TOBB Economics and Technology University Medical School, Ankara, Turkey.

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http://dx.doi.org/10.1177/1708538119881592DOI Listing
April 2020

Mood disorders, survival and medical compliance.

Acta Cardiol 2020 Dec 15;75(8):809. Epub 2019 Sep 15.

Department of Cardiology, Ankara City Hospital, Ankara, Turkey.

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http://dx.doi.org/10.1080/00015385.2019.1666228DOI Listing
December 2020

Predictors of Early and Late New-Onset Atrial Fibrillation in the Course of Acute Myocardial Infarction.

Angiology 2020 02 12;71(2):193. Epub 2019 Sep 12.

Department of Cardiology, University of Health Sciences, Ankara City Hospital, Ankara, Turkey.

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http://dx.doi.org/10.1177/0003319719874619DOI Listing
February 2020

Right ventricular pacing maneuvers for the differential diagnosis of supraventricular tachycardia.

Pacing Clin Electrophysiol 2019 10 18;42(10):1419-1420. Epub 2019 Sep 18.

Department of Cardiology, University of Health Sciences, Ankara City Hospital, Ankara, Turkey.

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http://dx.doi.org/10.1111/pace.13786DOI Listing
October 2019

A Rare Cause of Multiple Pseudoaneurysms of Radial Artery After Coronary Angiography: Behcet's Disease.

Turk Kardiyol Dern Ars 2019 Jul;47(5):410-412

Department of Cardiology, Türkiye Yüksek İhtisas Training and Research Hospital, Ankara, Turkey.

Patients with Behçet's disease are at risk for iatrogenic aneurysms after interventions. Presently described is the case of a 55-year-old male with multiple pseudoaneurysms occurring in the late period after a coronary angiography procedure performed via the radial artery. There was no previous diagnosis of vasculitis. Behçet's disease was revealed to be the underlying pathology.
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http://dx.doi.org/10.5543/tkda.2018.73184DOI Listing
July 2019

A dangerous and risky relationship: Esophagus and left atrium.

Pacing Clin Electrophysiol 2019 05 21;42(5):568-569. Epub 2019 Feb 21.

Department of Cardiology, University of Health Sciences, Yüksek Ihtisas Training and Research Hospital, Ankara, Turkey.

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http://dx.doi.org/10.1111/pace.13630DOI Listing
May 2019

The association of estimated whole blood viscosity with hemodynamic parameters and prognosis in patients with heart failure.

Biomark Med 2019 02 23;13(2):69-82. Epub 2019 Jan 23.

Cardiology Department, Turkey Yuksek Ihtisas Training & Research Hospital, Ankara, Turkey.

Aim: We aimed to investigate the association of estimated whole blood viscosity (WBV) with hemodynamic parameters and prognosis in patients with heart failure with reduced ejection fraction.

Materials & Methods: Total of 542 patients were included and followed-up for median 13 months.

Results: The WBV parameters had negative relationship with right atrium pressure and positive correlation with cardiac index. The WBV parameters were found to be independent predictors of composite end point (CEP) and all-cause mortality. Every one cP increases of WBV(h) and WBV(l) were associated with 17 and 1% reductions of CEP. In Kaplan-Meier analysis, patients with low WBV quartiles were found to have significantly more CEP.

Conclusion: Being an easily accessible and costless prognosticator, WBV seems to be a novel marker for determining prognosis and an emerging tool to individualize heart failure with reduced ejection fraction management.
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http://dx.doi.org/10.2217/bmm-2018-0309DOI Listing
February 2019

Lower rates of vitamin-K-antagonists usage are also related to physicians' and patients' comfort with novel oral anticoagulants.

Acta Cardiol 2020 02 16;75(1):95. Epub 2019 Jan 16.

Department of Cardiology, Turkiye Yuksek Ihtisas Research and Education Hospital, Ankara, Turkey.

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http://dx.doi.org/10.1080/00015385.2018.1555900DOI Listing
February 2020

The association between left ventricular mass index and coronary collateral circulation in patients with chronic total occlusion.

Turk Kardiyol Dern Ars 2019 01;47(1):21-28

Department of Cardiology, Türkiye Yüksek İhtisas Training and Research Hospital, Ankara, Turkey.

Objective: Left ventricular (LV) hypertrophy predisposes the myocardium to ischemia through several mechanisms. The LV mass index (LVMI) is used as a readily available and reliable measurement of LV hypertrophy. The LVMI can also be used to evaluate LV remodeling. The hypothesis of this study was that LV hypertrophy might augment coronary collateralization in patients with chronic total occlusion (CTO) and the aim was to research any association between LVMI and collateral formation in CTO. As a secondary goal, specific LV geometric types that might be associated with collateral presence were also investigated.

Methods: A total of 305 patients with CTO were included and categorized into 4 groups based on Rentrop grade.

Results: The LVMI demonstrated an incremental linear trend as the Rentrop grade increased. In the receiver operating characteristic curve, the likelihood that a cut-off value of 100.1 g/m2 would accurately differentiate patients with collaterals from those without collaterals was 75.8%, with 68.5% sensitivity and 68.6% specificity. A 1 gram/m2 increase in LVMI was associated with a 7.5% greater likelihood of collateral development. In addition, compared with normal geometry, the presence of eccentric hypertrophy was associated with 6.7 times higher odds of the presence of coronary collaterals.

Conclusion: The results of this study indicated that a greater LVMI predicted coronary collateral presence. Furthermore, having an eccentric geometric type of hypertrophy increased the likelihood of coronary collaterals more than other geometries. This finding signified that in addition to LV wall thickness, the type of hypertrophy was also decisive in predicting collateral presence.
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http://dx.doi.org/10.5543/tkda.2018.60497DOI Listing
January 2019

New horizon for ventricular pacing.

Pacing Clin Electrophysiol 2018 12 11;41(12):1691. Epub 2018 Nov 11.

Department of Cardiology, Yüksek Ihtisas Training and Research Hospital, University of Health Sciences, Ankara, Turkey.

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http://dx.doi.org/10.1111/pace.13518DOI Listing
December 2018

Beyond Lipids: Antiarrhythmic Effects of Statins.

Angiology 2019 03 13;70(3):283. Epub 2018 Sep 13.

Department of Cardiology, University of Health Sciences, Yüksek Ihtisas Training and Research Hospital, Ankara, Turkey.

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http://dx.doi.org/10.1177/0003319718799585DOI Listing
March 2019

[Increased myocardial energy expenditure in cardiac syndrome X: More work, more pain].

Turk Kardiyol Dern Ars 2018 09;46(6):446-454

Department of Cardiology, Türkiye Yüksek İhtisas Training and Research Hospital, Ankara, Turkey.

Objective: The aim of this study was to assess the myocardial energy expenditure (MEE) in patients with cardiac syndrome X (CSX) and to examine its association with exercise electrocardiogram (ECG) parameters.

Methods: A total of 99 patients who underwent coronary angiography and who were diagnosed as having normal coronary arteries were included. The patients were divided into 2 groups based on symptoms and exercise ECG parameters: 56 CSX patients and 43 control patients with a negative stress test. MEE was calculated using transthoracic echocardiography-derived parameters: circumferential end-systolic stress, left ventricular ejection time, and stroke volume.

Results: In patients with CSX, the MEE at rest was 28% higher in than the control group (89.2±36.3 vs. 69.8±17.2 cal/minute). Correlation analysis revealed a moderately negative correlation between MEE and the Duke treadmill score (DTS) (ß:-0.456; p<0.001). Receiver operating characteristic analysis with a cut-off value of 74.6 cal/minute for MEE had a sensitivity of 78.1% and a specificity of 75.3% for the prediction of CSX (area under the curve: 0.872; p<0.001). An extra 1 calorie spent per minute at rest increased the likelihood of CSX by about 86% (odds ratio: 1.863).

Conclusion: This study demonstrated that MEE was greater in CSX patients compared with a control group. Increased MEE was determined to be an independent predictor of CSX. DTS was inversely correlated with MEE. Increased MEE may have a crucial role in CSX pathophysiology.
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http://dx.doi.org/10.5543/tkda.2018.76967DOI Listing
September 2018

An unusual cause of angina pectoris due to dynamic coronary artery compression and successful treatment with cardiac surgical reconstruction.

Interact Cardiovasc Thorac Surg 2019 02;28(2):318-320

Department of Cardiovascular Surgery, TOBB Economy and Tecnology University Hospital, Ankara, Turkey.

Extrinsic compression of coronary arteries causing angina pectoris is very unusual. No data regarding the optimal treatment for coronary artery compression due to dilated cardiac chambers have been reported. In this case report, we describe a man with severe mitral valve stenosis and the dilated left atrium, which resulted in coronary artery compression, and the successful management of his condition by surgical reconstruction.
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http://dx.doi.org/10.1093/icvts/ivy218DOI Listing
February 2019

[Daptomycin in left-sided endocarditis: A single center experience].

Turk Kardiyol Dern Ars 2017 Jun;45(4):310-315

Department of Cardiology, Türkiye Yüksek İhtisas Training and Research Hospital, Ankara, Turkey.

Objective: Infective endocarditis (IE) carries a high risk of cardiac morbidity and mortality, despite advances in the contemporary armamentarium. Along with the development of antibiotic resistant strains, research focusing on the efficacy of novel agents other than standard antibiotic regimens continues. Daptomycin, one of these antibiotics, is approved for the treatment of Staphylococcus bacteremia and right-sided endocarditis. This retrospective study was an investigation of the effectiveness of daptomycin in patients with left-sided IE.

Methods: Fourteen patients (mean age 50.9±16.5; range 24 to 70 years) with the diagnosis of left-sided IE based on modified Duke criteria received daptomycin as monotherapy. Outcome was evaluated according to clinical improvement, microbiological eradication, and in-hospital mortality.

Results: Blood culture was positive in 13 patients (92.8%) and staphylococci were isolated in all but 1 patient (92.3%). Daptomycin was administered as monotherapy at a dose of 6 or 8 mg/kg/day for mean of 40.6±4.4 days. Clinical recovery rate was 71.4% and microbiological eradication rate was 85.7%. Mean duration of clinical recovery was 8.7±3.2 days and duration of microbiological eradication was 11.1±3.6 days. Side effects developed in 6 patients, but drug discontinuation was not required in any patient. Ten patients improved without complications. Two patients were lost due to heart failure and multiple-organ failure while treatment was continuing, and 2 patients died in early cardiac postoperative period.

Conclusion: Daptomycin is an effective and safe alternative to standard antibiotic therapy for the treatment of left-sided IE.
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http://dx.doi.org/10.5543/tkda.2017.60784DOI Listing
June 2017

Successful Percutaneous Coronary Intervention for Chronic Total Occlusion of Left Anterior Descending Coronary Artery in a Patient with Dextrocardia.

Int J Angiol 2016 Dec 25;25(5):e70-e72. Epub 2015 May 25.

Department of Cardiology, Medicana International Ankara Hospital, Ankara, Turkey.

Dextrocardia is a rare cardiac anomaly in which the heart is located in the right chest along with the cardiac long axis directing to the right and inferiorly. Although, it is a rare clinical phenomenon, coronary artery disease with dextrocardia is presumed to be of similar frequency as in the general population. Percutaneous coronary intervention has some technical difficulties in these patients. We hereby report a male patient with dextrocardia who was previously treated with coronary artery bypass graft surgery.
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http://dx.doi.org/10.1055/s-0035-1544177DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5186304PMC
December 2016

Percutaneous closure of coronary artery fistula: long-term follow-up results.

Postepy Kardiol Interwencyjnej 2015 12;11(4):318-22. Epub 2015 Jan 12.

Department of Cardiology, Turkiye Yuksek Ihtisas Hospital, Ankara, Turkey.

Introduction: Coronary artery fistula consists of abnormal congenital connections between a coronary artery and cardiac chambers, a coronary vessel or an intrathoracic vessel that can be complicated by intracardiac shunts, endocarditis, myocardial infarction, or coronary aneurysms. Recent reports have emphasized the efficacy of percutaneous transcatheter techniques as an alternative to surgical closure, but the reported experience is relatively limited.

Aim: To assess angiographic outcomes in a series of 20 patients who underwent transcatheter closure of coronary artery fistula.

Material And Methods: We evaluated all patients presenting with significant coronary artery fistula and undergoing transcatheter closure with coils and a vascular plug between March 2008 and June 2012.

Results: There were 20 patients (14 men; mean age: 53 ±8 years) with coronary artery fistula. Fistula diameter ranged from 4 to 12 mm; an average of three coils were used in the percutaneous procedure. Post-deployment angiograms demonstrated complete occlusion in all patients. The patients were followed up for 4 ±1.6 years. The control coronary computed tomographic angiography was performed in the sixth month and no patients had recanalization of the embolized vessel.

Conclusions: Percutaneous closure of coronary artery fistula is a safe and effective treatment modality.
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http://dx.doi.org/10.5114/pwki.2015.55603DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4679800PMC
December 2015

Procalcitonin: a marker of heart failure.

Acta Cardiol 2015 Aug;70(4):473-8

Objective: Serum procalcitonin levels are associated with congestive heart failure, but are not established biomarkers of the disease. We evaluated the predictive value of serum procalcitonin levels for diagnosing heart failure and assessing its severity.

Methods And Results: This retrospective, case-control study involved 59 subjects (mean age 59.7-10.1 years; 38 males), including 21 outpa- tients and 19 inpatients with heart failure and left ventricular ejection fractions <45%, and 19 healthy controls. Serum procalcitonin levels were measured and compared among the 3 groups. Procalcitonin levels were significantly higher among inpatients (median [interquartile range], 1.45 [0.25-5.801 ng/mL) than among the outpatients (0.35 [0.001.-1.70] ng/mL; P< 0.001) or controls (0.05 [0.02-0.08] ng/mL; P< 0.0011. Using a procalcitonin cut-off level of 0.09 ng/mL, 35 (87.5%) of the 40 inpatients and outpatients were procalcitonin-positive; all control individuals were procalcitonin-negative. Serum procalcitonin levels differentiated between heart failure patients and healthy controls (sensitivity, 88.9% [95% confidence interval, 75.9-96.2%]; specificity, 100% [82.2-100.0%]; positive predictive value, 100% [91.1-100.0%]; negative predictive value, 79.2% [57.8-92.8%]). Pro calcitonin levels were >0.53 ng/mL in 4/21 (19%) outpatients and in 16/19 (84.2%) inpatients. The sensitivity and specificity of serum procalcitonin levels for differentiating between inpatients and outpatients were 84.2% and 81.0%, respectively (positive predictive value 80% [95% confidence interval, 67.6-92.4%] and 85.0% [73.9-96.1%], respectively).

Conclusion: Serum procalcitonin levels, showing high sensitivity and specificity for diagnosing and assessing the severity of heart failure in this small study, might be considered ootential heart failure biomarkers.
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http://dx.doi.org/10.1080/ac.70.4.3096896DOI Listing
August 2015

[A rare complication of cardiac radiofrequency catheter ablation: Esophageal irritation].

Turk Kardiyol Dern Ars 2015 Jun;43(4):389-91

Department of Cardiology, Medicana International Ankara Hospital, Ankara, Turkey.

The complication rate of radiofrequency catheter ablation varies depending on patient characteristics and treatment, and has been reported to be approximately 3%. Esophageal irritation is one significant complication of catheter ablation, and its most common result is atrio-esophageal fistulae. However, rarely, unexpected complications and clinical variants occur due to irritation of the vagal nerve or peri-esophageal tissue without fistula formation. In this case report, attention is drawn to this rare complication in two cases, one of which occurred after paraseptal-epicardial accessory pathway ablation, and the other after atrial fibrillation ablation. Both were symptomatic with severe gag reflex.
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http://dx.doi.org/10.5543/tkda.2015.36926DOI Listing
June 2015
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