Publications by authors named "Ozcan Ozeke"

303 Publications

Telltale termination of an A-on-V tachycardia with two blocked atrial activations: What is the mechanism?

Pacing Clin Electrophysiol 2021 Aug 18. Epub 2021 Aug 18.

Ankara City Hospital, Department of Cardiology, University of Health Sciences, Ankara, Turkey.

The termination of tachycardia may provide important clues toward the mechanism of the tachycardia and that close vigilance may clinch the diagnosis before proceeding to other pacing maneuvers.
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http://dx.doi.org/10.1111/pace.14343DOI Listing
August 2021

Monocyte-to-HDL-cholesterol ratio is associated with Ascending Aorta Dilatation in Patients with Bicuspid Aortic Valve.

Afr Health Sci 2021 Mar;21(1):96-104

Department of Cardiology, Yuksek Ihtisas Education and Research Hospital, Ankara/Turkey.

Background: The importance of monocyte count-to-HDL-cholesterol ratio (MHR) in cardio- vascular diseases has been shown in various studies. Ascending aortic dilatation (AAD) is a common complication in the patients with bicuspid aortic valve. In this study, we aimed to investigate the relationship between MHR and the presence of aortic dilatation in the patients with bicuspid aortic valve.

Methods: The study population included totally 347 patients with bicuspid aortic valve.169 patients with aortic dilatation (ascending aorta diameter ≥ 4.0 cm) and 178 patients with no aortic dilatation. Echocardiographic and laboratory measurement was done and compared between groups.

Results: The mean age of the participants was 44.7 ± 15.4 years and average ascending aorta diameter was 3.2 ± 0.3 cm in dilatation negative group and 4.4 ± 0.4 cm in positive group. MHR was significantly increased in in patients with aortic dilatation. MHR and uric acid level was independently associated with the presence of aortic dilatation in the patients with bicuspid aortic valve.

Conclusion: We found a significant relationship between MHR and aortic dilatation in the patients with bicuspid aortic valve.
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http://dx.doi.org/10.4314/ahs.v21i1.14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8356613PMC
March 2021

The prognostic role of cardiac troponin in hospitalized COVID-19 patients.

Atherosclerosis 2021 05 17;325:83-88. Epub 2021 Apr 17.

University of Health Sciences, Ankara City Hospital, Department of Cardiology, Ankara, Turkey.

Background And Aims: Myocardial injury defined by elevation of cardiac troponins (cTn) in the course of coronavirus disease 2019 (COVID-19) pandemic has been reported, though not fully characterized yet. Using the Turkish nationwide centralized COVID-19 database, we sought to determine whether cTn measured within 24 h of admission may help identify 30-day all-cause mortality in hospitalized patients.

Methods: This retrospective cohort study was conducted at all hospitals in Turkey between March 11, 2020, and June 22, 2020. All hospitalized COVID-19 patients (≥18 years) who had cTn measurements within 24 h of admission were included. The primary outcome was 30-day all-cause mortality.

Results: A total of 14,855 COVID-19 patients (median age 49 years and 54% male) from 81 provinces of Turkey were included. Of these, 2020 patients (13.6%) were transferred to intensive care unit, 1165 patients (7.8%) needed mechanical ventilation, and 882 patients (5.9%) died during hospitalization. The prevalence of cTn positivity was 6.9% (n = 1027) in the hospitalized patients. cTn positivity was 5% in those patients alive at 30-day, and 44% in those who died. In multivariable Cox proportional hazard regression model, age, lactate dehydrogenase, and cTn were the strongest predictors of 30-day mortality, irrespective of cTn definition as a continuous, ordinal variable, or dichotomic variables.

Conclusions: A single measurement of cTn at admission in patients with COVID-19 is associated with 30-day all-cause mortality and may have an important prognostic role for optimizing risk stratification.
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http://dx.doi.org/10.1016/j.atherosclerosis.2021.04.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8052510PMC
May 2021

The transition of the tachycardia from narrow to wide by a spontaneous atrial premature beat: What is the mechanism?

J Arrhythm 2021 Apr 29;37(2):462-463. Epub 2021 Jan 29.

Department of Cardiology University of Health Sciences Ankara City Hospital Ankara Turkey.

The transition of the tachycardia from narrow to wide by a spontaneous atrial premature contraction causing a long-short sequence and right branch block.
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http://dx.doi.org/10.1002/joa3.12499DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8021983PMC
April 2021

Effect of chelation therapy on arrhythmogenic and basal ECG parameters of lead exposed workers.

Arch Environ Occup Health 2021 Apr 10:1-7. Epub 2021 Apr 10.

Department of Cardiology, Ankara City Hospital, Ankara, Turkey.

Lead exposure has etiological role on cardiovascular system diseases as hypertension, atherosclerosis, stroke, and arrhythmic events. In this study, we aimed to compare the basal and arrhythmogenic ECG parameters of lead exposed workers before and after chelation therapy and to evaluate the effect of acute change of blood lead levels on ECG. Fourty consecutive occupationally lead exposed workers were enrolled, demographic, blood, echocardiographic, and electrocardiographic data's were analyzed before and after chelation therapy. Pmax, P min, P Wave Dispersion, and QT Dispersion values which are arrhythmia predictors were significantly lower after chelation therapy compared to values before chelation therapy. Lead exposed workers are under the risk of ventricular and atrial arrythmias and chelation treatment has a positive effect on these parameters.
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http://dx.doi.org/10.1080/19338244.2021.1910116DOI Listing
April 2021

A dual nodal response to the parahisian pacing and induction of the retrograde right bundle branch block maneuvers.

J Arrhythm 2021 Feb 7;37(1):266-268. Epub 2020 Dec 7.

Department of Cardiology Ankara City Hospital University of Health Sciences Ankara Turkey.

We presented intracardiac electrograms during the parahisian pacing, which represent three types of retrograde conduction and focus on the mechanism of types of retrograde conduction on wide QRS complexes and conclude that the two types of QRS of the retrograde conduction resulted from the presence or absence of retrograde block at the right bundle branch.
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http://dx.doi.org/10.1002/joa3.12474DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7896456PMC
February 2021

When You Hear Hoofbeats, Look for Horses, Not Zebras.

Circulation 2021 Feb 22;143(8):862-864. Epub 2021 Feb 22.

University of Health Sciences, Ankara City Hospital, Department of Cardiology, Turkey.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.120.052468DOI Listing
February 2021

Lower levels of triiodothyronine are associated with poor hemodynamic profile and all-cause mortality in heart failure.

Biomark Med 2021 Mar 10;15(4):273-283. Epub 2021 Feb 10.

Department of Cardiology, Ankara City Hospital, Ankara, Turkey.

We aimed to assess the association of triiodothyronine (T3) hormone with invasive hemodynamic parameters and all-cause mortality in heart failure with reduced ejection fraction (HFrEF).  About 483 HFrEF patients were enrolled. Patients with the lowest T3 tertile had advanced New York Heart Association (NYHA) classes, had higher uric acid, brain natriuretic peptide. T3 level had a positive correlation with cardiac index (CI) and a negative correlation with pulmonary vascular resistance and pulmonary capillary wedge pressure. Adjusted with NYHA III-IV classes, uric acid, aspartate aminotransferase and CI, T3 level was found to be an independent predictor of all-cause mortality. In Kaplan-Meier analysis, the lowest T3 tertile had the lowest survival function. Free T3 is positively correlated with CI and negatively correlated with pulmonary vascular resistance and pulmonary capillary wedge pressure in patients with HFrEF. Lower levels of T3 seems to be a poor prognostic factor in this particular patient population.
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http://dx.doi.org/10.2217/bmm-2020-0425DOI Listing
March 2021

Development and validation of clinical prediction model to estimate the probability of death in hospitalized patients with COVID-19: Insights from a nationwide database.

J Med Virol 2021 May 10;93(5):3015-3022. Epub 2021 Feb 10.

Department of Cardiology, University of Health Sciences, Ankara City Hospital, Ankara, Turkey.

In the current study, we aimed to develop and validate a model, based on our nationwide centralized coronavirus disease 2019 (COVID-19) database for predicting death. We conducted an observational study (CORONATION-TR registry). All patients hospitalized with COVID-19 in Turkey between March 11 and June 22, 2020 were included. We developed the model and validated both temporal and geographical models. Model performances were assessed by area under the curve-receiver operating characteristic (AUC-ROC or c-index), R , and calibration plots. The study population comprised a total of 60,980 hospitalized COVID-19 patients. Of these patients, 7688 (13%) were transferred to intensive care unit, 4867 patients (8.0%) required mechanical ventilation, and 2682 patients (4.0%) died. Advanced age, increased levels of lactate dehydrogenase, C-reactive protein, neutrophil-lymphocyte ratio, creatinine, albumine, and D-dimer levels, and pneumonia on computed tomography, diabetes mellitus, and heart failure status at admission were found to be the strongest predictors of death at 30 days in the multivariable logistic regression model (area under the curve-receiver operating characteristic = 0.942; 95% confidence interval: 0.939-0.945; R  = .457). There were also favorable temporal and geographic validations. We developed and validated the prediction model to identify in-hospital deaths in all hospitalized COVID-19 patients. Our model achieved reasonable performances in both temporal and geographic validations.
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http://dx.doi.org/10.1002/jmv.26844DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8014660PMC
May 2021

Termination, Advancement, and Delaying Responses to His Synchronous Premature Ventricular Contractions During Narrow QRS Tachycardia: What Are the Possible Mechanisms?

J Innov Card Rhythm Manag 2021 Jan 15;12(1):4376-4380. Epub 2021 Jan 15.

Department of Cardiology, Ankara City Hospital, University of Health Sciences, Ankara, Turkey.

The differential diagnosis of a regular, narrow QRS, long-R-P tachycardia includes atypical atrioventricular nodal reentry tachycardia, atrial tachycardia, and atrioventricular reentry tachycardia via a slowly conducting accessory pathway with decremental conduction properties. Almost all described diagnostic maneuvers in the electrophysiology laboratory have exceptions to their primary interpretation. The usual proviso is that the observation must be reproducible.
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http://dx.doi.org/10.19102/icrm.2021.120108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7834043PMC
January 2021

Whole blood viscosity in the evaluation of thrombogenic milieu in mitral stenosis.

Biomark Med 2021 02 20;15(3):181-190. Epub 2021 Jan 20.

Ankara City Hospital, Cardiology Department, Ankara, Turkey.

We aimed to assess the association of whole blood with thromboembolic milieu in significant mitral stenosis patients. We included 122 patients and classified patients into two groups as having thrombogenic milieu, thrombogenic milieu (+), otherwise patients without thrombogenic milieu, thrombogenic milieu (-). Whole blood viscosity (WBV) in both shear rates were higher in thrombogenic milieu (+) group comparing with thrombogenic milieu (-). WBV at high shear rate and WBV at low shear rate parameters were moderately correlated with grade of spontaneous echo contrast. Adjusted with other parameters, WBV parameters at both shear rates were associated with presence of thrombogenic milieu. We found that extrapolated WBV at both shear rates was significantly associated with the thrombogenic milieu in mitral stenosis. This easily available parameter may provide additional perspective about thrombogenic diathesis.
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http://dx.doi.org/10.2217/bmm-2020-0329DOI Listing
February 2021

Left atrial or left atrial appendage thrombus as a cardiac source of embolus: that is the question or Faustian bargain for left atrial appendage closure?

Europace 2021 02;23(2):324

Department of Cardiology, University of Health Sciences, Ankara City Hospital, Kardiyoloji Klinigi, Bilkent, 06800 Ankara, Turkey.

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http://dx.doi.org/10.1093/europace/euaa337DOI Listing
February 2021

Change in the atrial activation timing and sequence during narrow QRS tachycardia: What is the mechanism?

J Cardiovasc Electrophysiol 2021 01 23;32(1):148-150. Epub 2020 Nov 23.

Department of Cardiology, University of Health Sciences, Ankara City Hospital, Ankara, Turkey.

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http://dx.doi.org/10.1111/jce.14813DOI Listing
January 2021

The role of Frailty on Adverse Outcomes Among Older Patients with COVID-19.

J Infect 2020 12 28;81(6):944-951. Epub 2020 Sep 28.

University of Health Sciences, Ankara City Hospital, Department of Cardiology, Ankara, Turkey.

Background: Diagnosis and screening of frailty, a condition characterized by an increased vulnerability to adverse outcomes of COVID-19, has emerged as an essential clinical tool which is strongly recommended by healthcare providers concerned with hospitalized elderly population. The data showing the role of frailty in patients infected with COVID-19 is needed.

Methods: This was a nationwide cohort study conducted at all hospitals in Turkey. All COVID-19 hospitalized patients (≥ 65 years) were included. Patients who were alive and not discharged up to July 20, 2020, were excluded. The frailty was assessed by using the "Hospital Frailty Risk Score" (HFRS). Patients were classified into three risk groups of frailty based on previously validated cut points as low (<5 points), intermediate (5-15 points), and high (>15 points). Additionally, patients who had the HFRS of ≥5 were defined as frail. The primary outcome was in-hospital mortality rates by frailty group.

Results: Between March 11, 2020, and June 22, 2020, a total of 18,234 COVID-19 patients from all of 81 provinces of Turkey were included. Totally, 12,295 (67.4%) patients were defined as frail (HFRS of >5) of which 2,801 (15.4%) patients were categorized in the highest level of frailty (HFRS of >15). Observed in-hospital mortality rates were 697 (12.0%), 1,751 (18.2%) and 867 (31.0%) in low, intermediate and high hospital frailty risk, respectively (p<0.001). Compared with low HFRS (<5), the adjusted odds ratios for in-hospital mortality were 1.482 (1.334-1.646) for intermediate HFRS (5-15) and 2.084; 95% CI, 1.799-2.413 for high HFRS (>15).

Conclusions: As a claims-based frailty model, the HFRS provides clinicians and health systems, a standardized tool for an effective detection and grading of frailty in patients in COVID-19. A frailty-based tailored management of the older population may provide a more accurate risk categorization for both therapeutic and preventive strategies.
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http://dx.doi.org/10.1016/j.jinf.2020.09.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7521439PMC
December 2020

The other side of the medallion in heart failure: Reverse metabolic syndrome.

Nutr Metab Cardiovasc Dis 2020 10 2;30(11):2041-2050. Epub 2020 Jul 2.

Ankara City Hospital, Cardiology Department, Ankara, Turkey.

Background And Aims: Lower levels of cardiovascular risk factors are associated with an increase in mortality in H.F. To explain this paradox, the term reverse metabolic syndrome (RMetS) has recently been proposed. We suggest defining these patients with lower levels of three risk factors can be combined under the heading "RMetS." We aimed to investigate the effect of MetS and RMetS on hemodynamic parameters and prognosis in patients with H.F. and reduced ejection fraction (HFrEF).

Methods And Results: We included 304 patients who were performed right heart catheterization and followed up for a median of 16 (0-48) months. We first grouped patients according to the presence of MetS or not, then we added the RMetS category and stratified patients into three groups as MetS, RMetS, and metabolic healthy. Compared with not MetS group, Pulmonary arterial pressures and VO were higher in MetS group. In the second step, LVEF, CI, VOI, O delivery, and LVSWI were lowest in RMetS, pulmonary artery pressures were higher in MetS group. In multivariate Cox regression analysis, being in RMetS group was associated with 2.4 times and 1.8 times increased risk for composite end point (CEP) and all-cause mortality, respectively. In Kaplan Meier analysis, RMetS had the highest all-cause mortality and CEP.

Conclusions: We determined that RMetS patients had the worst prognosis with unfavorable hemodynamic profile. Hence, a better understanding of the pathophysiology of RMetS may help refine the treatment targets of CV risk factors, may yield new interventions targeting catabolic syndrome.
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http://dx.doi.org/10.1016/j.numecd.2020.06.027DOI Listing
October 2020

Coronary Sinus Diameter to Inferior Vena Cava Diameter Ratio in the Diagnosis of Cardiac Tamponade: A Novel Approach.

J Comput Assist Tomogr 2020 Jul/Aug;44(4):599-604

From the Cardiology Department, Ankara City Hospital.

Background: In cardiac tamponade, coronary sinus (CS) as an intrapericardial structure can be easily compressed, whereas inferior vena cava (IVC) dilates. This inverse relationship may augment their roles in the evaluation of tamponade imaging.

Aim: We assessed the usefulness of computerized tomographic measures of CS diameter and also CS/IVC ratio to predict tamponade in clinically stable patients with large pericardial effusion.

Methods: Sixty-six clinically stable patients who had large pericardial effusions were included. Coronary sinus diameter was measured from the point at 1 cm proximal to the CS ostium. Inferior vena cava diameter was measured from the segment between its right atrial orifice and hepatic vein.

Results: Patients with tamponade had smaller CS diameter and CS/IVC ratio. After adjusting with other parameters, only either CS diameter or CS/IVC ratio predicted tamponade, respectively. (Nagelkerke r value for CS was 53.7% and 72.1% for CS/IVC ratio). In Receiver Operating Characteristic Curve analysis, a cutoff value of 6.85 mm for CS diameter had 82.6% sensitivity and 83.7% specificity and a cutoff value of 27% for CS/IVC ratio had 87.0% sensitivity and 86.0% specificity for predicting cardiac tamponade.

Conclusions: The tomographic measures of both the CS diameter and the CS/IVC ratio predicted tamponade in clinically stable patients with large pericardial effusion. Compared with CS diameter, CS/IVC ratio seemed to be a more powerful predictor of tamponade.
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http://dx.doi.org/10.1097/RCT.0000000000001064DOI Listing
July 2020

EP lessons by legendary quartet of "Jackman-Klein-Prystowsky-Stevenson": "A priceless opportunity" during the COVID-19 era.

J Cardiovasc Electrophysiol 2020 12 22;31(12):3104-3105. Epub 2020 Jun 22.

Department of Cardiology, Ankara City Hospital, Health Sciences University, Ankara, Turkey.

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http://dx.doi.org/10.1111/jce.14615DOI Listing
December 2020

His bundle pacing using a simple stylet and a standard active fixation electrode.

J Electrocardiol 2020 Jul - Aug;61:37-40. Epub 2020 Apr 29.

Division of Arrhythmia and Electrophysiology, Department of Cardiology, University of Health Sciences, Ankara City Hospital, Ankara, Turkey.

Conventionally, His bundle pacing (HBP) is achieved using specially designed pacing leads and delivery sheaths. This paper describes the feasibility of permanent HBP with a pre-shaped simple stylet and a standard active-fixation electrode, through axillary vein access, without using dedicated delivery tools. This method may be a feasible and safe alternative to the only commercially available system.
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http://dx.doi.org/10.1016/j.jelectrocard.2020.04.020DOI Listing
June 2021

Simple approaches to reduce radiation in the electrophysiology laboratory.

J Cardiovasc Electrophysiol 2020 09 2;31(9):2544-2545. Epub 2020 Jun 2.

Department of Cardiology, Division of Arrhythmia and Electrophysiology, University of Health Sciences, Ankara City Hospital, Ankara, Turkey.

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http://dx.doi.org/10.1111/jce.14587DOI Listing
September 2020

A new risk model for the evaluation of the thromboembolic milieu in patients with atrial fibrillation: the PALSE score.

Kardiol Pol 2020 08 1;78(7-8):732-740. Epub 2020 Jun 1.

Cardiology Department, Ankara City Hospital, Ankara, Turkey

Background: The evaluation of thromboembolic risk is the cornerstone of atrial fibrillation (AF) management. Thromboembolic risk is associated with the presence of left atrial (LA) thrombus and spontaneous echo contrast (SEC), namely the thromboembolic milieu.

Aims: We aimed to assess the predictors of the thromboembolic milieu in terms of LA thrombus and/ or SEC in patients with paroxysmal AF undergoing electrical cardioversion or catheter ablation, and to develop an effective risk model for detecting the thromboembolic milieu.

Methods: We included a total of 434 patients with nonvalvular paroxysmal AF who underwent transesophageal echocardiography prior to cardioversion or catheter ablation.

Results: In patients with the thromboembolic milieu, total protein and C‑reactive protein levels, LA diameter, and systolic pulmonary artery pressure (SPAP) were higher, while left ventricular ejection fraction (LVEF) was lower than in patients without the thromboembolic milieu. In a multivariate logistic regression analysis, age, total protein levels, LVEF, LA diameter, and SPAP were independent predictors of LA thrombus and/or SEC. In a receiver operating characteristic curve analysis, the optimal cutoff values for the discrimination of patients with the thromboembolic milieu were as follows: 60 years for age; 7.3 mg/dl for total protein; 40% for LVEF; 40 mm for LA diameter; and 35 mm Hg for SPAP. Based on these cutoff values, we developed a novel risk model, namely, the PALSE score. The area under the curve for the PALSE score was 0.833. Patients with a PALSE score lower than 1 did not show thrombus or spontaneous echo contrast.

Conclusions: The PALSE score, which includes total protein levels, age, LA diameter, SPAP, and LVEF, seemed to accurately predict the presence of the thromboembolic milieu in patients with paroxysmal AF.
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http://dx.doi.org/10.33963/KP.15402DOI Listing
August 2020

Percutaneous Interventricular Septal Access Guided by Subcostal Echocardiography and Fluoroscopy for Ventricular Tachycardia Ablation in a Patient with Aortic and Mitral Mechanical Valves.

J Innov Card Rhythm Manag 2019 Jul 15;10(7):3719-3721. Epub 2019 Jul 15.

Department of Cardiology, Turkiye Yuksek Ihtisas Training and Research Hospital, Health Sciences University, Ankara, Turkey.

Mechanical prosthetic aortic and mitral valves preclude either a retrograde aortic or transseptal approach to the left ventricular (LV) endocardium. Several operators have reported on the application of nonconventional techniques for ventricular tachycardia (VT) ablation including transventricular septal puncture, epicardial approach, transmechanical valve approach, transcoronary venous approach, and transapical approach. Incorporating transventricular access to the LV under intracardiac echocardiography (ICE) guidance has been previously attempted in VT ablation procedures in patients with both aortic and mitral mechanical valves. However, while ICE is readily used in the United States, its use is less common in Europe, since the health insurance agencies largely do not cover the costs of ICE catheters. We therefore herein present a case of VT ablation in the LV using a transventricular approach in a patient who underwent mechanical double valve replacement performed under subcostal echocardiographic and fluoroscopic guidance.
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http://dx.doi.org/10.19102/icrm.2019.100702DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7252692PMC
July 2019

The other side of the circulation: The arterial system.

J Cardiovasc Electrophysiol 2020 08 29;31(8):2267. Epub 2020 May 29.

Division of Arrhythmia and Electrophysiology, Department of Cardiology, Ankara City Hospital, University of Health Sciences, Ankara, Turkey.

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http://dx.doi.org/10.1111/jce.14574DOI Listing
August 2020

Overcoming difficulties related with persistent left superior vena cava.

J Cardiovasc Electrophysiol 2020 08 25;31(8):2264-2265. Epub 2020 May 25.

Division of Arrhythmia and Electrophysiology, Department of Cardiology, Ankara City Hospital, University of Health Sciences, Ankara, Turkey.

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http://dx.doi.org/10.1111/jce.14578DOI Listing
August 2020

An alternative way to reach the ventricular surface of the sinuses of valsalva: Antegrade transseptal approach.

J Cardiovasc Electrophysiol 2020 08 16;31(8):2257-2259. Epub 2020 May 16.

Division of Arrhythmia and Electrophysiology, Department of Cardiology, University of Health Sciences, Ankara City Hospital, Ankara, Turkey.

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http://dx.doi.org/10.1111/jce.14536DOI Listing
August 2020

Bear track hypothesis in outcomes of ventricular tachycardia ablation: Risk factor or risk marker or both for heart failure?

Pacing Clin Electrophysiol 2020 06 30;43(6):621-622. Epub 2020 May 30.

Department of Cardiology, Ankara City Hospital, Yuksek Iktisas Kalp Damar Hastanesi, Health Sciences University, Ankara, Turkey.

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http://dx.doi.org/10.1111/pace.13942DOI Listing
June 2020

The boundaries between primary and secondary prevention with defibrillators after acute myocardial infarction: Gray areas of the terminology and definition.

J Cardiovasc Electrophysiol 2020 07 11;31(7):1888-1889. Epub 2020 May 11.

Department of Cardiology, Ankara City Hospital, Health Sciences University, Ankara, Turkey.

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http://dx.doi.org/10.1111/jce.14528DOI Listing
July 2020

Wettability and roughness: Important determinants of bacterial adhesion and biofilm formation.

J Cardiovasc Electrophysiol 2020 07 30;31(7):1885. Epub 2020 Apr 30.

Division of Arrhythmia and Electrophysiology, Department of Cardiology, Ankara City Hospital, University of Health Sciences, Ankara, Turkey.

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http://dx.doi.org/10.1111/jce.14515DOI Listing
July 2020

Multimodality imaging to characterize a mass on a lead.

J Cardiovasc Electrophysiol 2020 07 24;31(7):1884. Epub 2020 Apr 24.

Department of Cardiology, Division of Arrhythmia and Electrophysiology, Ankara City Hospital, University of Health Sciences, Ankara, Turkey.

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http://dx.doi.org/10.1111/jce.14504DOI Listing
July 2020

Usefulness of positive T wave in lead aVR in predicting arrhythmic events and mortality in patients with hypertrophic cardiomyopathy.

Heart Rhythm 2020 08 14;17(8):1312-1319. Epub 2020 Apr 14.

Department of Cardiology, Turkiye Yuksek Ihtisas Training and Research Hospital, Ankara, Turkey.

Background: Positive T wave in lead aVR (TaVR) has been associated with increased risk of adverse events in patients with various cardiovascular diseases.

Objective: The purpose of this study was to investigate the prevalence and prognostic significance of positive TaVR in patients with hypertrophic cardiomyopathy (HCM).

Methods: This study investigated 421 consecutive patients with HCM (177 women; age 51.1 ± 14.9 years). Admission electrocardiogram was examined for the presence of a positive TaVR. The primary endpoint was defined as a composite of major arrhythmic events (MAEs), which included sudden cardiac death, sustained ventricular tachycardia or fibrillation, or appropriate implantable cardioverter-defibrillator therapy. Cardiovascular mortality and all-cause death were evaluated as secondary endpoints.

Results: During median follow-up period of 6.0 years (interquartile range 4.0-11.6 years), 53 patients (12.6%) experienced the primary endpoint. On multivariable competing analysis, after adjusting for other confounding factors, the presence of positive TaVR was found to be an independent and strong predictor of the primary composite endpoint. Time-dependent receiver operating characteristic analysis, net reclassification index, and integrated discrimination improvement showed that the addition of positive TaVR to conventional HCM risk factors improved prediction of arrhythmic events. However, in subgroup analysis, a positive TaVR lost statistical significance in patients with apical HCM but remained significant in patients with all other hypertrophy patterns.

Conclusion: Positive TaVR is associated with MAE in HCM patients, independent of and incremental to traditional risk factors.
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http://dx.doi.org/10.1016/j.hrthm.2020.03.030DOI Listing
August 2020

Time perception: What's "early"? What's "delayed"?

J Cardiovasc Electrophysiol 2020 07 16;31(7):1880. Epub 2020 Apr 16.

Department of Cardiology Division of Arrhythmia and Electrophysiology, Ankara City Hospital, University of Health Sciences, Ankara, Turkey.

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http://dx.doi.org/10.1111/jce.14492DOI Listing
July 2020
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