Owen Pornillos

Owen Pornillos

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Owen Pornillos

Owen Pornillos

Publications by authors named "Owen Pornillos"

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TRIM5α self-assembly and compartmentalization of the HIV-1 viral capsid.

Nat Commun 2020 Mar 11;11(1):1307. Epub 2020 Mar 11.

Department of Chemistry, Chicago Center for Theoretical Chemistry, Institute for Biophysical Dynamics, and James Franck Institute, The University of Chicago, Chicago, IL, 60637, USA.

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http://dx.doi.org/10.1038/s41467-020-15106-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7066149PMC
March 2020

Biochemical Reconstitution of HIV-1 Assembly and Maturation.

J Virol 2020 Feb 14;94(5). Epub 2020 Feb 14.

Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, Virginia, USA

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http://dx.doi.org/10.1128/JVI.01844-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7022372PMC
February 2020

Hierarchical assembly governs TRIM5α recognition of HIV-1 and retroviral capsids.

Sci Adv 2019 11 27;5(11):eaaw3631. Epub 2019 Nov 27.

Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, VA, USA.

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http://dx.doi.org/10.1126/sciadv.aaw3631DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6881174PMC
November 2019

Restriction of HIV-1 and other retroviruses by TRIM5.

Nat Rev Microbiol 2019 09 16;17(9):546-556. Epub 2019 Jul 16.

Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, VA, USA.

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http://dx.doi.org/10.1038/s41579-019-0225-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6858284PMC
September 2019

Exploration of the TRIM Fold of MuRF1 Using EPR Reveals a Canonical Antiparallel Structure and Extended COS-Box.

J Mol Biol 2019 Jul 22;431(15):2900-2909. Epub 2019 May 22.

Nucleic Acids Structure Research Group, University of Dundee, Dundee, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.jmb.2019.05.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6599887PMC
July 2019

Maturation of retroviruses.

Curr Opin Virol 2019 06 8;36:47-55. Epub 2019 Jun 8.

Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, VA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.coviro.2019.05.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6730672PMC
June 2019

TRIM25 Binds RNA to Modulate Cellular Anti-viral Defense.

J Mol Biol 2018 12 17;430(24):5280-5293. Epub 2018 Oct 17.

Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, VA, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00222836183084
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http://dx.doi.org/10.1016/j.jmb.2018.10.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6289755PMC
December 2018

Retrovirus Restriction by TRIM5α: RINGside at a Cage Fight.

Cell Host Microbe 2018 12;24(6):751-753

Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, VA, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S19313128183059
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http://dx.doi.org/10.1016/j.chom.2018.11.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6464375PMC
December 2018

Structure and catalytic activation of the TRIM23 RING E3 ubiquitin ligase.

Proteins 2017 Oct 24;85(10):1957-1961. Epub 2017 Jul 24.

Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, Virginia.

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http://dx.doi.org/10.1002/prot.25348DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5638660PMC
October 2017

TRIM5α SPRY/coiled-coil interactions optimize avid retroviral capsid recognition.

PLoS Pathog 2017 Oct 17;13(10):e1006686. Epub 2017 Oct 17.

Department of Molecular Physiology and Biological Physics, University of Virginia School of Medicine, Charlottesville, Virginia, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1006686DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5667893PMC
October 2017

Mechanism of Ska Recruitment by Ndc80 Complexes to Kinetochores.

Dev Cell 2017 05;41(4):438-449.e4

Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, 1340 Jefferson Park Avenue, Pinn Hall, Room 6014, Charlottesville, VA 22908, USA. Electronic address:

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http://dx.doi.org/10.1016/j.devcel.2017.04.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5926205PMC
May 2017

Mechanism of TRIM25 Catalytic Activation in the Antiviral RIG-I Pathway.

Cell Rep 2016 08 14;16(5):1315-1325. Epub 2016 Jul 14.

Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, VA 22908, USA. Electronic address:

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5076470PMC
http://dx.doi.org/10.1016/j.celrep.2016.06.070DOI Listing
August 2016

Crystal structure of an HIV assembly and maturation switch.

Elife 2016 07 14;5. Epub 2016 Jul 14.

Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, United States.

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http://dx.doi.org/10.7554/eLife.17063DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4946879PMC
July 2016

STRUCTURAL VIROLOGY. X-ray crystal structures of native HIV-1 capsid protein reveal conformational variability.

Science 2015 Jul 4;349(6243):99-103. Epub 2015 Jun 4.

Christopher S. Bond Life Sciences Center, University of Missouri, Columbia, MO 65211, USA. Department of Molecular Microbiology and Immunology, University of Missouri School of Medicine, Columbia, MO 65211, USA. Department of Biochemistry, University of Missouri, Columbia, MO 65211, USA.

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http://dx.doi.org/10.1126/science.aaa5936DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4584149PMC
July 2015

Structural basis of HIV-1 capsid recognition by PF74 and CPSF6.

Proc Natl Acad Sci U S A 2014 Dec 17;111(52):18625-30. Epub 2014 Dec 17.

Department of Molecular Physiology and Biological Physics, Center for Membrane Biology, Cardiovascular Research Center, and Division of Cardiovascular Medicine, Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA 22908

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http://dx.doi.org/10.1073/pnas.1419945112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4284599PMC
December 2014

The tripartite motif coiled-coil is an elongated antiparallel hairpin dimer.

Proc Natl Acad Sci U S A 2014 Feb 3;111(7):2494-9. Epub 2014 Feb 3.

Department of Molecular Physiology and Biological Physics and The Myles H. Thaler Center for AIDS and Human Retrovirus Research, University of Virginia, Charlottesville, VA 22908.

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http://dx.doi.org/10.1073/pnas.1318962111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3932864PMC
February 2014

Assembly and architecture of HIV.

Adv Exp Med Biol 2012 ;726:441-65

Department of Molecular Physiology and Biological Physics, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.

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http://dx.doi.org/10.1007/978-1-4614-0980-9_20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6743068PMC
April 2012

Hexagonal assembly of a restricting TRIM5alpha protein.

Proc Natl Acad Sci U S A 2011 Jan 27;108(2):534-9. Epub 2010 Dec 27.

Department of Molecular Physiology and Biological Physics, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.

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http://dx.doi.org/10.1073/pnas.1013426108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3021009PMC
January 2011

Atomic-level modelling of the HIV capsid.

Nature 2011 Jan;469(7330):424-7

Department of Molecular Physiology and Biological Physics, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA.

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http://dx.doi.org/10.1038/nature09640DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3075868PMC
January 2011

Disulfide bond stabilization of the hexameric capsomer of human immunodeficiency virus.

J Mol Biol 2010 Sep 26;401(5):985-95. Epub 2010 Jun 26.

Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, VA 22908, USA.

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http://dx.doi.org/10.1016/j.jmb.2010.06.042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3050670PMC
September 2010

Inhibition of protein kinase CK2 expression and activity blocks tumor cell growth.

Mol Cell Biochem 2010 Jan 21;333(1-2):159-67. Epub 2009 Jul 21.

Celgene Corporation, 4550 Towne Centre Court, San Diego, CA 92121, USA.

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http://link.springer.com/10.1007/s11010-009-0216-0
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http://dx.doi.org/10.1007/s11010-009-0216-0DOI Listing
January 2010

X-ray structures of the hexameric building block of the HIV capsid.

Cell 2009 Jun 11;137(7):1282-92. Epub 2009 Jun 11.

Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1016/j.cell.2009.04.063DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2840706PMC
June 2009

X-ray structure of EmrE supports dual topology model.

Proc Natl Acad Sci U S A 2007 Nov 16;104(48):18999-9004. Epub 2007 Nov 16.

Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, CB-105, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1073/pnas.0709387104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2141897PMC
November 2007

Functional characterization of the heterooligomeric EbrAB multidrug efflux transporter of Bacillus subtilis.

Biochemistry 2007 May 7;46(17):5218-25. Epub 2007 Apr 7.

Division of Biological Sciences, University of California at San Diego, La Jolla, California 92093-0116, USA.

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http://dx.doi.org/10.1021/bi7001604DOI Listing
May 2007

Inverted repeat domains in membrane proteins.

FEBS Lett 2006 Jan 28;580(2):358-62. Epub 2005 Dec 28.

The Scripps Research Institute, Department of Molecular Biology, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1016/j.febslet.2005.12.054DOI Listing
January 2006

X-ray structure of the EmrE multidrug transporter in complex with a substrate.

Science 2005 Dec;310(5756):1950-3

Department of Molecular Biology, The Scripps Institute, 10550 North Torrey Pines Road, CB-105, Jolla, CA 92037, USA.

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http://dx.doi.org/10.1126/science.1119776DOI Listing
December 2005

Mechanisms of enveloped RNA virus budding.

Trends Cell Biol 2002 Dec;12(12):569-79

Dept of Biochemistry, University of Utah, Salt Lake City, UT 84132, USA.

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http://dx.doi.org/10.1016/s0962-8924(02)02402-9DOI Listing
December 2002

Structure of the Tsg101 UEV domain in complex with the PTAP motif of the HIV-1 p6 protein.

Nat Struct Biol 2002 Nov;9(11):812-7

Department of Biochemistry, University of Utah, Salt Lake City, Utah 84132, USA.

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http://dx.doi.org/10.1038/nsb856DOI Listing
November 2002

Structure and functional interactions of the Tsg101 UEV domain.

EMBO J 2002 May;21(10):2397-406

Department of Biochemistry and Center for Biomolecular Interactions Analysis, University of Utah, Salt Lake City 84132, USA.

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http://emboj.embopress.org/cgi/doi/10.1093/emboj/21.10.2397
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http://dx.doi.org/10.1093/emboj/21.10.2397DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC125378PMC
May 2002