Owen J Sansom

Owen J Sansom

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Owen J Sansom

Publications by authors named "Owen J Sansom"

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Neutrophils: Homing in on the myeloid mechanisms of metastasis.

Mol Immunol 2019 Jun;110:69-76

Cancer Research UK Beatson Institute, Garscube Estate, Switchback Rd, Glasgow G61 1BD, UK; Institute of Cancer Sciences, University of Glasgow, Glasgow, UK. Electronic address:

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http://dx.doi.org/10.1016/j.molimm.2017.12.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6544568PMC
June 2019

RAL GTPases Drive Intestinal Stem Cell Function and Regeneration through Internalization of WNT Signalosomes.

Cell Stem Cell 2019 Apr 7;24(4):592-607.e7. Epub 2019 Mar 7.

Cancer Research UK Beatson Institute, Glasgow G61 1BD, UK; Institute of Cancer Sciences, University of Glasgow, Glasgow G61 1QH, UK. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S19345909193004
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http://dx.doi.org/10.1016/j.stem.2019.02.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459002PMC
April 2019

Preclinical Evaluation of AZ12601011 and AZ12799734, Inhibitors of Transforming Growth Factor Superfamily Type 1 Receptors.

Mol Pharmacol 2019 02 20;95(2):222-234. Epub 2018 Nov 20.

Cancer Research UK Beatson Institute, Garscube Estate, Bearsden, Glasgow, United Kingdom (L.C.S., G.J.F., B.H., O.J.S., G.J.I.);Institute of Cancer Sciences, University of Glasgow, Glasgow, United Kingdom (O.J.S., G.J.I.) Division of Cellular Medicine, School of Medicine, University of Dundee, Dundee, United Kingdom (R.G.T., L.S.S.); and AstraZeneca Bioscience, Oncology (G.D.H., S.T.B., B.R.D.) and Medicinal Chemistry, Oncology (F.W.G.), IMED Biotech Unit, AstraZeneca, Cambridge, United Kingdom

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http://dx.doi.org/10.1124/mol.118.112946DOI Listing
February 2019

FGFR3 mutation increases bladder tumourigenesis by suppressing acute inflammation.

J Pathol 2018 11 19;246(3):331-343. Epub 2018 Sep 19.

School of Medicine, Dentistry and Nursing, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.

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http://dx.doi.org/10.1002/path.5143DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334176PMC
November 2018

Cancer cell adaptation to hypoxia involves a HIF-GPRC5A-YAP axis.

EMBO Mol Med 2018 11;10(11)

Cancer Research UK Colorectal Tumour Biology Group, School of Cellular & Molecular Medicine, Faculty of Life Sciences University of Bristol, Bristol, UK

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http://embomolmed.embopress.org/lookup/doi/10.15252/emmm.201
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http://dx.doi.org/10.15252/emmm.201708699DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6220329PMC
November 2018

The role of mTOR-mediated signals during haemopoiesis and lineage commitment.

Biochem Soc Trans 2018 10 28;46(5):1313-1324. Epub 2018 Aug 28.

Institute of Cancer Sciences, College of Medicine, Veterinary and Life Sciences, University of Glasgow, Glasgow, U.K.

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http://biochemsoctrans.org/lookup/doi/10.1042/BST20180141
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http://dx.doi.org/10.1042/BST20180141DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6195642PMC
October 2018

Systems level expression correlation of Ras GTPase regulators.

Cell Commun Signal 2018 08 15;16(1):46. Epub 2018 Aug 15.

Centre for Genomic Regulation (CRG), Systems Biology Programme. The Barcelona Institute of Science and Technology, Dr. Aiguader 88, Barcelona, 08003, Spain.

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http://dx.doi.org/10.1186/s12964-018-0256-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6094892PMC
August 2018

Intestinal Stem Cell Dynamics: A Story of Mice and Humans.

Cell Stem Cell 2018 06;22(6):785-787

CRUK Beatson Institute, Glasgow G61 1BD, UK; Institute of Cancer Sciences (ICS), University of Glasgow, Glasgow G61 1QH, UK. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2018.05.005DOI Listing
June 2018

Role of Wnt signalling in advanced prostate cancer.

J Pathol 2018 May 1;245(1):3-5. Epub 2018 Mar 1.

CRUK Beatson Institute, Bearsden, Glasgow, UK.

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http://dx.doi.org/10.1002/path.5029DOI Listing
May 2018

Spatiotemporal regulation of liver development by the Wnt/β-catenin pathway.

Sci Rep 2018 02 9;8(1):2735. Epub 2018 Feb 9.

Centre for Regenerative Medicine, Department of Biology & Biochemistry, University of Bath, Claverton Down, Bath, BA2 7AY, UK.

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http://dx.doi.org/10.1038/s41598-018-20888-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5807466PMC
February 2018

Gemcitabine-Induced TIMP1 Attenuates Therapy Response and Promotes Tumor Growth and Liver Metastasis in Pancreatic Cancer.

Cancer Res 2017 11 1;77(21):5952-5962. Epub 2017 Aug 1.

Department of Oncology, CRUK/MRC Oxford Institute for Radiation Oncology, University of Oxford, Oxford, United Kingdom.

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http://dx.doi.org/10.1158/0008-5472.CAN-16-2833DOI Listing
November 2017

Defining key concepts of intestinal and epithelial cancer biology through the use of mouse models.

Carcinogenesis 2017 10;38(10):953-965

Cancer Research UK Beatson Institute, Garscube Estate, Bearsden, Glasgow, G61 1BD, UK.

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http://dx.doi.org/10.1093/carcin/bgx080DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5862284PMC
October 2017

PTEN deficiency permits the formation of pancreatic cancer in the absence of autophagy.

Cell Death Differ 2017 07 20;24(7):1303-1304. Epub 2017 Jan 20.

Cancer Research UK Beatson Institute, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK.

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http://dx.doi.org/10.1038/cdd.2016.120DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5520160PMC
July 2017

Intestinal stem cell overproliferation resulting from inactivation of the APC tumor suppressor requires the transcription cofactors Earthbound and Erect wing.

PLoS Genet 2017 Jul 14;13(7):e1006870. Epub 2017 Jul 14.

Department of Molecular and Systems Biology and the Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth College, Hanover, NH, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1006870DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5510812PMC
July 2017

R-spondin Is More Than Just Wnt's Sidekick.

Dev Cell 2017 06;41(5):456-458

Cancer Research UK Beatson Institute, Glasgow, Scotland; Institute of Cancer Sciences, University Of Glasgow, Glasgow, Scotland. Electronic address:

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http://dx.doi.org/10.1016/j.devcel.2017.05.018DOI Listing
June 2017

Lgr5 joins the club of gastric stem cell markers in the corpus.

Nat Cell Biol 2017 Jun;19(7):752-754

Cancer Research UK Beatson Institute, Garscube Estate, Bearsden, Glasgow G61 1BD, UK and at the Institute of Cancer Sciences, University of Glasgow, Glasgow G61 1BD, UK.

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http://dx.doi.org/10.1038/ncb3567DOI Listing
June 2017

Loss of TGF-β signaling drives cSCC from skin stem cells - More evidence.

Cell Cycle 2017 03 18;16(5):386-387. Epub 2016 Nov 18.

a Division of Cancer Research , School of Medicine, University of Dundee , Dundee , UK.

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https://www.tandfonline.com/doi/full/10.1080/15384101.2016.1
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http://dx.doi.org/10.1080/15384101.2016.1259892DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5351926PMC
March 2017

Genetic dissection of colorectal cancer progression by orthotopic transplantation of engineered cancer organoids.

Proc Natl Acad Sci U S A 2017 03 7;114(12):E2357-E2364. Epub 2017 Mar 7.

Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences and University Medical Center (UMC) Utrecht, 3584 CT Utrecht, The Netherlands;

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http://dx.doi.org/10.1073/pnas.1701219114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5373343PMC
March 2017

Hypermutation In Pancreatic Cancer.

Gastroenterology 2017 01 15;152(1):68-74.e2. Epub 2016 Nov 15.

Wolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, University of Glasgow, Glasgow, Scotland, United Kingdom; Department of Surgery, Bankstown Hospital, Bankstown, Sydney, New South Wales, Australia; South Western Sydney Clinical School, Faculty of Medicine, University of New South Wales Australia, Liverpool, New South Wales, Australia; West of Scotland Pancreatic Unit, Glasgow Royal Infirmary, Glasgow, United Kingdom. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00165085163518
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http://dx.doi.org/10.1053/j.gastro.2016.09.060DOI Listing
January 2017

CXCR2 inhibition in pancreatic cancer: opportunities for immunotherapy?

Immunotherapy 2017 01;9(1):9-12

Cancer Research UK Beatson Institute, Switchback Rd, Glasgow, G61 1BD, UK.

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http://dx.doi.org/10.2217/imt-2016-0115DOI Listing
January 2017

Functional exploration of colorectal cancer genomes using Drosophila.

Nat Commun 2016 11 29;7:13615. Epub 2016 Nov 29.

Department of Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, Annenberg 25-40, New York, New York 10029, USA.

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http://dx.doi.org/10.1038/ncomms13615DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5141297PMC
November 2016

Notch3 drives development and progression of cholangiocarcinoma.

Proc Natl Acad Sci U S A 2016 10 10;113(43):12250-12255. Epub 2016 Oct 10.

Medical Research Council Centre for Regenerative Medicine, University of Edinburgh, Edinburgh EH16 4UU, United Kingdom; The Scottish Liver Transplant Unit, Royal Infirmary of Edinburgh, Edinburgh EH16 4SA, United Kingdom

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http://dx.doi.org/10.1073/pnas.1600067113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5086988PMC
October 2016

A YY1-dependent increase in aerobic metabolism is indispensable for intestinal organogenesis.

Development 2016 10;143(20):3711-3722

Rutgers University, Department of Genetics, Human Genetics Institute of New Jersey (HGINJ), 145 Bevier Road, Piscataway Township, NJ 08854, USA

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http://dx.doi.org/10.1242/dev.137992DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5087649PMC
October 2016

Constitutively active transforming growth factor β receptor 1 in the mouse ovary promotes tumorigenesis.

Oncotarget 2016 Jul;7(27):40904-40918

Department of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX, USA.

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http://dx.doi.org/10.18632/oncotarget.10149DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5173031PMC
July 2016

Sleeping Beauty screen reveals Pparg activation in metastatic prostate cancer.

Proc Natl Acad Sci U S A 2016 07 29;113(29):8290-5. Epub 2016 Jun 29.

Cancer Research UK Beatson Institute, Bearsden, Glasgow G61 1BD, United Kingdom; Institute of Cancer Sciences, University of Glasgow, Glasgow G61 1QH, United Kingdom;

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http://dx.doi.org/10.1073/pnas.1601571113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4961202PMC
July 2016

Genomic analyses identify molecular subtypes of pancreatic cancer.

Authors:
Peter Bailey David K Chang Katia Nones Amber L Johns Ann-Marie Patch Marie-Claude Gingras David K Miller Angelika N Christ Tim J C Bruxner Michael C Quinn Craig Nourse L Charles Murtaugh Ivon Harliwong Senel Idrisoglu Suzanne Manning Ehsan Nourbakhsh Shivangi Wani Lynn Fink Oliver Holmes Venessa Chin Matthew J Anderson Stephen Kazakoff Conrad Leonard Felicity Newell Nick Waddell Scott Wood Qinying Xu Peter J Wilson Nicole Cloonan Karin S Kassahn Darrin Taylor Kelly Quek Alan Robertson Lorena Pantano Laura Mincarelli Luis N Sanchez Lisa Evers Jianmin Wu Mark Pinese Mark J Cowley Marc D Jones Emily K Colvin Adnan M Nagrial Emily S Humphrey Lorraine A Chantrill Amanda Mawson Jeremy Humphris Angela Chou Marina Pajic Christopher J Scarlett Andreia V Pinho Marc Giry-Laterriere Ilse Rooman Jaswinder S Samra James G Kench Jessica A Lovell Neil D Merrett Christopher W Toon Krishna Epari Nam Q Nguyen Andrew Barbour Nikolajs Zeps Kim Moran-Jones Nigel B Jamieson Janet S Graham Fraser Duthie Karin Oien Jane Hair Robert Grützmann Anirban Maitra Christine A Iacobuzio-Donahue Christopher L Wolfgang Richard A Morgan Rita T Lawlor Vincenzo Corbo Claudio Bassi Borislav Rusev Paola Capelli Roberto Salvia Giampaolo Tortora Debabrata Mukhopadhyay Gloria M Petersen Donna M Munzy William E Fisher Saadia A Karim James R Eshleman Ralph H Hruban Christian Pilarsky Jennifer P Morton Owen J Sansom Aldo Scarpa Elizabeth A Musgrove Ulla-Maja Hagbo Bailey Oliver Hofmann Robert L Sutherland David A Wheeler Anthony J Gill Richard A Gibbs John V Pearson Nicola Waddell Andrew V Biankin Sean M Grimmond

Nature 2016 Mar 24;531(7592):47-52. Epub 2016 Feb 24.

Queensland Centre for Medical Genomics, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Brisbane, Queensland 4072, Australia.

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http://dx.doi.org/10.1038/nature16965DOI Listing
March 2016

Mouse models of intestinal cancer.

J Pathol 2016 Jan 29;238(2):141-51. Epub 2015 Oct 29.

Cancer Research UK Beatson Institute, Glasgow, UK.

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http://dx.doi.org/10.1002/path.4645DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4832380PMC
January 2016

Opposing effects of TIGAR- and RAC1-derived ROS on Wnt-driven proliferation in the mouse intestine.

Genes Dev 2016 Jan 17;30(1):52-63. Epub 2015 Dec 17.

Cancer Research UK Beatson Institute, Glasgow, G61 1BD, United Kingdom.

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http://dx.doi.org/10.1101/gad.271130.115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4701978PMC
January 2016

ADF and Cofilin1 Control Actin Stress Fibers, Nuclear Integrity, and Cell Survival.

Cell Rep 2015 Dec 19;13(9):1949-64. Epub 2015 Nov 19.

Edinburgh Cancer Research UK Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Crewe Road South, Edinburgh EH4 2XR, UK. Electronic address:

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http://www.cell.com/cell-reports/pdf/S2211-1247(15)01245-0.p
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http://linkinghub.elsevier.com/retrieve/pii/S221112471501245
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http://dx.doi.org/10.1016/j.celrep.2015.10.056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4678118PMC
December 2015

Elp3 drives Wnt-dependent tumor initiation and regeneration in the intestine.

J Exp Med 2015 Nov 2;212(12):2057-75. Epub 2015 Nov 2.

Interdisciplinary Cluster for Applied Genoproteomics, University of Liège, 4000 Liège, Belgium Laboratory of Medical Chemistry, University of Liège, 4000 Liège, Belgium GIGA-Signal Transduction, University of Liège, 4000 Liège, Belgium Walloon Excellence in Life Sciences and Biotechnology, 1300 Wavre, Belgium

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http://dx.doi.org/10.1084/jem.20142288DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4647259PMC
November 2015

GEMMs as preclinical models for testing pancreatic cancer therapies.

Dis Model Mech 2015 Oct;8(10):1185-200

Cancer Research UK Beatson Institute, Glasgow, G61 1BD, UK

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http://dx.doi.org/10.1242/dmm.021055DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4610236PMC
October 2015

Serine 62-Phosphorylated MYC Associates with Nuclear Lamins and Its Regulation by CIP2A Is Essential for Regenerative Proliferation.

Cell Rep 2015 Aug 30;12(6):1019-31. Epub 2015 Jul 30.

Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, 20520 Turku, Finland; Department of Pathology, University of Turku, 20520 Turku, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.07.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4535171PMC
August 2015

Reserve stem cells: Differentiated cells reprogram to fuel repair, metaplasia, and neoplasia in the adult gastrointestinal tract.

Sci Signal 2015 Jul 14;8(385):re8. Epub 2015 Jul 14.

Cancer Research UK Beatson Institute, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK.

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http://stke.sciencemag.org/lookup/doi/10.1126/scisignal.aaa7
Publisher Site
http://dx.doi.org/10.1126/scisignal.aaa7540DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4858190PMC
July 2015

Frizzled7 functions as a Wnt receptor in intestinal epithelial Lgr5(+) stem cells.

Stem Cell Reports 2015 May 16;4(5):759-67. Epub 2015 Apr 16.

Department of Anatomy and Neuroscience, University of Melbourne, Melbourne, VIC 3010, Australia; Victorian Infectious Diseases Reference Laboratory, Melbourne, VIC 3000, Australia; Curtin University, Perth, WA 6845, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2015.03.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4437483PMC
May 2015

Fascin expression is increased in metastatic lesions but does not correlate with progression nor outcome in melanoma.

Melanoma Res 2015 Apr;25(2):169-72

aBeatson Institute for Cancer Research, Glasgow bEdinburgh Cancer Centre cDepartment of Pathology, NHS Lothian, Western General Hospital dEdinburgh Cancer Research Centre, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, MRC Human Genetics Unit, Western General Hospital, Edinburgh, UK eMedical Oncology Group, Ingham Institute for Applied Medical Research, School of Medicine, University of New South Wales, New South Wales, Australia.

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http://dx.doi.org/10.1097/CMR.0000000000000135DOI Listing
April 2015