Owen A Ross

Owen A Ross

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Owen A Ross

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The unresolved role of mitochondrial DNA in Parkinson's disease: An overview of published studies, their limitations, and future prospects.

Neurochem Int 2019 Oct 21;129:104495. Epub 2019 Jun 21.

Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University, South Africa. Electronic address:

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http://dx.doi.org/10.1016/j.neuint.2019.104495DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6702091PMC
October 2019

A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer's disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity.

Authors:
Sven J van der Lee Olivia J Conway Iris Jansen Minerva M Carrasquillo Luca Kleineidam Erik van den Akker Isabel Hernández Kristel R van Eijk Najada Stringa Jason A Chen Anna Zettergren Till F M Andlauer Monica Diez-Fairen Javier Simon-Sanchez Alberto Lleó Henrik Zetterberg Marianne Nygaard Cornelis Blauwendraat Jeanne E Savage Jonas Mengel-From Sonia Moreno-Grau Michael Wagner Juan Fortea Michael J Keogh Kaj Blennow Ingmar Skoog Manuel A Friese Olga Pletnikova Miren Zulaica Carmen Lage Itziar de Rojas Steffi Riedel-Heller Ignacio Illán-Gala Wei Wei Bernard Jeune Adelina Orellana Florian Then Bergh Xue Wang Marc Hulsman Nina Beker Niccolo Tesi Christopher M Morris Begoña Indakoetxea Lyduine E Collij Martin Scherer Estrella Morenas-Rodríguez James W Ironside Bart N M van Berckel Daniel Alcolea Heinz Wiendl Samantha L Strickland Pau Pastor Eloy Rodríguez Rodríguez Bradley F Boeve Ronald C Petersen Tanis J Ferman Jay A van Gerpen Marcel J T Reinders Ryan J Uitti Lluís Tárraga Wolfgang Maier Oriol Dols-Icardo Amit Kawalia Maria Carolina Dalmasso Mercè Boada Uwe K Zettl Natasja M van Schoor Marian Beekman Mariet Allen Eliezer Masliah Adolfo López de Munain Alexander Pantelyat Zbigniew K Wszolek Owen A Ross Dennis W Dickson Neill R Graff-Radford David Knopman Rosa Rademakers Afina W Lemstra Yolande A L Pijnenburg Philip Scheltens Thomas Gasser Patrick F Chinnery Bernhard Hemmer Martijn A Huisman Juan Troncoso Fermin Moreno Ellen A Nohr Thorkild I A Sørensen Peter Heutink Pascual Sánchez-Juan Danielle Posthuma Jordi Clarimón Kaare Christensen Nilüfer Ertekin-Taner Sonja W Scholz Alfredo Ramirez Agustín Ruiz Eline Slagboom Wiesje M van der Flier Henne Holstege

Acta Neuropathol 2019 Aug 27;138(2):237-250. Epub 2019 May 27.

Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1007/s00401-019-02026-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6660501PMC
August 2019

Heritability and genetic variance of dementia with Lewy bodies.

Neurobiol Dis 2019 07 3;127:492-501. Epub 2019 Apr 3.

Department of Neurodegenerative Diseases, UCL Institute of Neurology, London, UK; UK Dementia Research Institute (UK DRI) at UCL, London, UK. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2019.04.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6588425PMC
July 2019

Diffuse Lewy Body Disease and Alzheimer Disease: Neuropathologic Phenotype Associated With the PSEN1 p.A396T Mutation.

J Neuropathol Exp Neurol 2019 Jul;78(7):585-594

Department of Pathology & Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana.

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http://dx.doi.org/10.1093/jnen/nlz039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6581554PMC
July 2019

Association of MAPT H1 subhaplotypes with neuropathology of lewy body disease.

Mov Disord 2019 Jun 24. Epub 2019 Jun 24.

Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA.

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http://dx.doi.org/10.1002/mds.27773DOI Listing
June 2019

Anticipation in a family with primary familial brain calcification caused by an SLC20A2 variant.

Neurol Neurochir Pol 2018 May - Jun;52(3):386-389. Epub 2018 Apr 11.

Department of Neurology, Mayo Clinic Florida, 4500 San Pablo Road, Jacksonville, FL 32224, USA. Electronic address:

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http://dx.doi.org/10.1016/j.pjnns.2018.03.007DOI Listing
May 2019

Age and Age-Related Diseases: Role of Inflammation Triggers and Cytokines.

Front Immunol 2018 9;9:586. Epub 2018 Apr 9.

Department of Neuroscience, Mayo Clinic, Jacksonville, FL, United States.

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http://dx.doi.org/10.3389/fimmu.2018.00586DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5900450PMC
May 2019

Parkinson's disease in Nigeria: A review of published studies and recommendations for future research.

Parkinsonism Relat Disord 2019 May 8;62:36-43. Epub 2018 Dec 8.

Neurology Unit, Department of Medicine, College of Health Sciences, Obafemi Awolowo University, Ile-Ife, Nigeria. Electronic address:

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http://dx.doi.org/10.1016/j.parkreldis.2018.12.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6556138PMC
May 2019

A comprehensive screening of copy number variability in dementia with Lewy bodies.

Neurobiol Aging 2019 03 24;75:223.e1-223.e10. Epub 2018 Oct 24.

Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK; UK Dementia Research Institute (UK DRI) at UCL, London, UK; Department of Medical Sciences and Institute of Biomedicine, iBiMED, University of Aveiro, Aveiro, Portugal. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01974580183038
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http://dx.doi.org/10.1016/j.neurobiolaging.2018.10.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6541211PMC
March 2019

No evidence for DNM3 as genetic modifier of age at onset in idiopathic Parkinson's disease.

Neurobiol Aging 2019 02 22;74:236.e1-236.e5. Epub 2018 Sep 22.

Department of Neurology, Oslo University Hospital, Oslo, Norway; Faculty of Medicine, University of Oslo, Oslo, Norway.

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http://dx.doi.org/10.1016/j.neurobiolaging.2018.09.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345552PMC
February 2019

point mutations and familial intracranial aneurysms.

Neurology 2018 12 9;91(23):e2170-e2181. Epub 2018 Nov 9.

From the Department of Neuroscience (O.L.-B., C.L., K.H., P.G., A.I.S., R.L.W., O.A.R.), Center for Individualized Medicine (P.R.B., J.M.), Department of Health Sciences Research (P.R.B., Y.A.), Department of Neurology (E.E., R.V.-d-C., W.D.F., J.M.), Clinical Research Internship Study Program (P.G.), Department of Neurosurgery (D.M., W.D.F.), and Department of Clinical Genomics (O.A.R.), Mayo Clinic, Jacksonville, FL; Center for Individualized Medicine (E.W.K.), Department of Health Sciences Research (E.W.K.), Department of Laboratory Medicine and Pathology (E.W.K.), Department of Clinical Genomics (E.W.K.), and Department of Biochemistry and Molecular Biology (A.N.S., K.J.C.), Mayo Clinic, Rochester, MN; Department of Biology (K.H., O.A.R.), Basic Research Internship in Neuroscience and Cancer, University of North Florida, Jacksonville; Program in Molecular Medicine (S.D.), University of Massachusetts Medical School, Worcester; Division of Genetics (M.B.B.), Department of Pediatrics, Nemours/Alfred I. duPont Hospital for Children, Wilmington, DE; and Section of Clinical Genetics & Genetic Counseling (S.J.), St. Christopher's Hospital for Children, Philadelphia, PA.

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http://www.neurology.org/lookup/doi/10.1212/WNL.000000000000
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http://dx.doi.org/10.1212/WNL.0000000000006614DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282233PMC
December 2018

Parkinson-Associated SNCA Enhancer Variants Revealed by Open Chromatin in Mouse Dopamine Neurons.

Am J Hum Genet 2018 12 29;103(6):874-892. Epub 2018 Nov 29.

McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2018.10.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288322PMC
December 2018

ε4 is associated with severity of Lewy body pathology independent of Alzheimer pathology.

Neurology 2018 09 24;91(12):e1182-e1195. Epub 2018 Aug 24.

From the Department of Neuroscience (D.W.D., M.E.M., A.I.S., R.W., N.E.-T., G.B., O.A.R.), Division of Biomedical Statistics and Informatics (M.G.H., N.N.D.), and Departments of Neurology (J.A.v.G., R.J.U., Z.K.W., N.E.-T., N.R.G.-R.) and Psychiatry and Psychology (T.J.F.), Mayo Clinic, Jacksonville, FL; and Department of Neurology (D.S.K., R.C.P., B.F.B.), Mayo Clinic, Rochester, MN.

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http://dx.doi.org/10.1212/WNL.0000000000006212DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161556PMC
September 2018

Association study between multiple system atrophy and TREM2 p.R47H.

Neurol Genet 2018 Aug 1;4(4):e257. Epub 2018 Aug 1.

Department of Neuroscience (K.O., S.K., Y.A.M, C.L., O.L.-B., R.L.W., A.I.S., S.F., S.G.Y., G.B., D.W.D., O.A.R.), Mayo Clinic, Jacksonville, FL; Department of Neurology (K.O.), Juntendo University Shizuoka Hospital, Izunokunishi, Shizuoka, Japan; Division of Biomedical Statistics and Informatics (M.G.H., E.R.V), Mayo Clinic, Jacksonville, FL; Department of Neurology (R.J.U., J.A.v.G., W.P.C., Z.K.W.), Mayo Clinic, Jacksonville, FL; Department of Neurology (P.A.L., W.S.), Mayo Clinic, Rochester, MN; Mayo Graduate School (O.A.R.), Neurobiology of Disease, Jacksonville, FL; and Department of Clinical Genomics (O.A.R.), Jacksonville, FL.

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http://dx.doi.org/10.1212/NXG.0000000000000257DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6089688PMC
August 2018

A novel link between trafficking and Lewy body disorders.

Lancet Neurol 2018 07 7;17(7):571-573. Epub 2018 Jun 7.

Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.

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http://dx.doi.org/10.1016/S1474-4422(18)30214-XDOI Listing
July 2018

Target-enriched sequencing of chromosome 17q21.31 in sporadic tauopathies reveals no candidate variants.

Neurobiol Aging 2018 06 11;66:177.e7-177.e10. Epub 2018 Jan 11.

Neurogenetics Laboratory, Division of Neurosciences, Center for Applied Medical Research, University of Navarra (CIMA), Pamplona, Spain; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, CIBERNED, Instituto de Salud Carlos III, Madrid, Spain; Movement Disorders Unit, Department of Neurology, Hospital Universitari Mutua de Terrassa, and Fundació per la Recerca Biomèdica i Social Mútua Terrassa, Terrassa, Barcelona, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2017.12.026DOI Listing
June 2018

Establishing diagnostic criteria for Perry syndrome.

J Neurol Neurosurg Psychiatry 2018 May 31;89(5):482-487. Epub 2017 Oct 31.

Department of Neurology, Fukuoka University School of Medicine, Fukuoka, Japan.

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http://dx.doi.org/10.1136/jnnp-2017-316864DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5909757PMC
May 2018

Comparison of clinical features among Parkinson's disease subtypes: A large retrospective study in a single center.

J Neurol Sci 2018 03 11;386:39-45. Epub 2018 Jan 11.

Department of Neurology, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jns.2018.01.013DOI Listing
March 2018

PINK1 Phosphorylates MIC60/Mitofilin to Control Structural Plasticity of Mitochondrial Crista Junctions.

Mol Cell 2018 03 15;69(5):744-756.e6. Epub 2018 Feb 15.

Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2018.01.026DOI Listing
March 2018

Investigating the genetic architecture of dementia with Lewy bodies: a two-stage genome-wide association study.

Lancet Neurol 2018 01 16;17(1):64-74. Epub 2017 Dec 16.

UK Dementia Research Institute, University College London, London, UK; Department of Molecular Neuroscience, UCL Institute of Neurology, University College London, London, UK; Department of Medical Sciences and Institute of Biomedicine, iBiMED, University of Aveiro, Aveiro, Portugal. Electronic address:

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http://dx.doi.org/10.1016/S1474-4422(17)30400-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5805394PMC
January 2018

DCTN1 variation in pathologically-confirmed PSP and CBD tauopathy.

Parkinsonism Relat Disord 2017 11 30;44:151-153. Epub 2017 Aug 30.

Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA. Electronic address:

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http://dx.doi.org/10.1016/j.parkreldis.2017.08.027DOI Listing
November 2017

Parkinson's disease susceptibility variants and severity of Lewy body pathology.

Parkinsonism Relat Disord 2017 Nov 11;44:79-84. Epub 2017 Sep 11.

Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA; Department of Clinical Genomics, Mayo Clinic, Jacksonville, FL, USA; Mayo Graduate School, Neurobiology of Disease, Mayo Clinic, Jacksonville, FL, USA. Electronic address:

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http://dx.doi.org/10.1016/j.parkreldis.2017.09.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5716921PMC
November 2017

Regional analysis and genetic association of nigrostriatal degeneration in Lewy body disease.

Mov Disord 2017 Nov 26;32(11):1584-1593. Epub 2017 Sep 26.

Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA.

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http://dx.doi.org/10.1002/mds.27184DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5915345PMC
November 2017

Identification of novel risk loci for restless legs syndrome in genome-wide association studies in individuals of European ancestry: a meta-analysis.

Lancet Neurol 2017 11;16(11):898-907

Institute of Neurogenomics, Helmholtz Zentrum München, German Research Centre for Environmental Health, Neuherberg, Germany; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany; Institute of Human Genetics, Technische Universität München, Munich, Germany; Neurologische Klinik und Poliklinik, Klinikum rechts der Isar der Technischen Universität München, Munich, Germany. Electronic address:

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http://dx.doi.org/10.1016/S1474-4422(17)30327-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5755468PMC
November 2017

DCTN1-related neurodegeneration: Perry syndrome and beyond.

Parkinsonism Relat Disord 2017 Aug 12;41:14-24. Epub 2017 Jun 12.

Department of Neurology, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL, 32224, USA. Electronic address:

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http://dx.doi.org/10.1016/j.parkreldis.2017.06.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5546300PMC
August 2017

Mitochondrial membrane protein-associated neurodegeneration.

Parkinsonism Relat Disord 2017 06 21;39:1-3. Epub 2017 Mar 21.

Department of Neuroscience, Mayo Clinic, Jacksonville, FL, United States; Department of Clinical Genomics, Mayo Clinic, Jacksonville, FL, United States.

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http://dx.doi.org/10.1016/j.parkreldis.2017.03.014DOI Listing
June 2017

Occurrence of Crohn's disease with Parkinson's disease.

Parkinsonism Relat Disord 2017 04 10;37:116-117. Epub 2017 Feb 10.

Department of Neurology, Mayo Clinic, Jacksonville, FL, United States. Electronic address:

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http://dx.doi.org/10.1016/j.parkreldis.2017.01.013DOI Listing
April 2017

Deep brain stimulation for levodopa-refractory benign tremulous parkinsonism.

Neurol Neurochir Pol 2016;50(5):383-6. Epub 2016 Jun 24.

Department of Neurology, Mayo Clinic, Jacksonville, United States. Electronic address:

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http://dx.doi.org/10.1016/j.pjnns.2016.05.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5012306PMC
January 2017

Analysis of C9orf72 repeat expansions in a large international cohort of dementia with Lewy bodies.

Neurobiol Aging 2017 01 2;49:214.e13-214.e15. Epub 2016 Sep 2.

Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK; Department of Medical Sciences and Institute of Biomedicine-iBiMED, University of Aveiro, Aveiro, Portugal. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2016.08.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5154872PMC
January 2017

Modifiers of LRRK2 parkinsonism: new therapeutic targets.

Lancet Neurol 2016 11 28;15(12):1200-1201. Epub 2016 Sep 28.

Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.

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http://dx.doi.org/10.1016/S1474-4422(16)30243-5DOI Listing
November 2016

Epigenetic regulation in Parkinson's disease.

Acta Neuropathol 2016 10 29;132(4):515-30. Epub 2016 Jun 29.

Department of Neuroscience, Mayo Clinic Jacksonville, 4500 San Pablo Road, Jacksonville, FL, 32224, USA.

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http://dx.doi.org/10.1007/s00401-016-1590-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5026906PMC
October 2016

TREM2 p.R47H substitution is not associated with dementia with Lewy bodies.

Neurol Genet 2016 Aug 14;2(4):e85. Epub 2016 Jul 14.

Department of Neuroscience (R.L.W., A.I.S.-O., M.E.M., O.L.-B., K.O., S.R., R.R., N.E.-T., D.W.D., O.A.R., C.L.), Division of Biomedical Statistics and Informatics (M.G.H.), Department of Neurology (N.E.-T., R.J.U., J.A.v.G., Z.K.W., N.R.G.-R.), Department of Psychiatry and Psychology (T.J.F., O.A.R.), Mayo Clinic, Jacksonville, FL; Department of Biology (A.I.S.-O., O.A.R.), University of North Florida, Jacksonville; Department of Psychiatry and Psychology (G.E.S.), Department of Radiology (K.K., V.J.L., D.T.J.), Department of Laboratory Medicine and Pathology (J.E.P., B.F.B.), Department of Neurology (J.E.P., D.T.J., R.S., J.G.-R., D.S.K., R.C.P.), Mayo Clinic, Rochester, MN; Department of Clinical and Health Psychology (G.E.S.), University of Florida, Gainesville; and Mayo Graduate School (T.J.F., O.A.R.), Neurobiology of Disease, Jacksonville, FL.

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http://dx.doi.org/10.1212/NXG.0000000000000085DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4946771PMC
August 2016

Tremor in progressive supranuclear palsy.

Parkinsonism Relat Disord 2016 06 22;27:93-7. Epub 2016 Mar 22.

Department of Neuropathology, 4500 San Pablo Road, Jacksonville, FL 32224, USA. Electronic address:

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http://dx.doi.org/10.1016/j.parkreldis.2016.03.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4887294PMC
June 2016

α-synuclein genetic variability: A biomarker for dementia in Parkinson disease.

Ann Neurol 2016 Jun 5;79(6):991-9. Epub 2016 May 5.

Centre for Applied Neurogenetics, Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada.

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http://doi.wiley.com/10.1002/ana.24664
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http://dx.doi.org/10.1002/ana.24664DOI Listing
June 2016

Rare variants in MC1R/TUBB3 exon 1 are not associated with Parkinson's disease.

Ann Neurol 2016 Feb 19;79(2):331. Epub 2016 Jan 19.

Departments of Neuroscience, Mayo Clinic, Jacksonville, FL.

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http://dx.doi.org/10.1002/ana.24581DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4755887PMC
February 2016

Autosomal dominant Parkinson's disease caused by SNCA duplications.

Parkinsonism Relat Disord 2016 Jan 3;22 Suppl 1:S1-6. Epub 2015 Sep 3.

Department of Neurology, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA. Electronic address:

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http://dx.doi.org/10.1016/j.parkreldis.2015.09.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4820832PMC
January 2016

Genetic susceptibility variants in parkinsonism.

Parkinsonism Relat Disord 2016 Jan 7;22 Suppl 1:S7-11. Epub 2015 Sep 7.

Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA; Department of Biology, University of North Florida, Jacksonville, FL 32224, USA; School of Medicine and Medical Science, University College Dublin, Dublin, Ireland; Mayo Graduate School, Neurobiology of Disease, Jacksonville, FL, USA. Electronic address:

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http://dx.doi.org/10.1016/j.parkreldis.2015.09.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4662622PMC
January 2016

Exome Variant Mining in Familial Parkinson Disease: Will Replication Find the Gold?

JAMA Neurol 2016 Jan;73(1):21-2

Department of Neuroscience, Mayo Clinic, Jacksonville, Florida.

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http://dx.doi.org/10.1001/jamaneurol.2015.3536DOI Listing
January 2016

Mitochondrial targeting sequence variants of the CHCHD2 gene are a risk for Lewy body disorders.

Neurology 2015 Dec 11;85(23):2016-25. Epub 2015 Nov 11.

From the Department of Neuroscience (K.O., S.K., F.C.F., M.A., C.L., O.L.-B., E.L.M.-L., A.I.S.-O., R.L.W., W.S., D.W.D., O.A.R.), the Division of Biomedical Statistics and Informatics (M.G.H.), and the Department of Neurology (A.J.S., R.J.U., N.R.G.-R., Z.K.W.), Mayo Clinic, Jacksonville, FL; the Department of Neurology (K.O., M.A., K.N., M.F., N.H.), Juntendo University School of Medicine, Tokyo, Japan; the Dublin Neurological Institute at the Mater Misericordiae University Hospital (A.M., T.L.), Conway, and Institute of Biomolecular & Biomedical Research, University College Dublin, Ireland; the Department of Neurology (J.S., G.O., M.R.), Medical University of Silesia, Katowice; the Department of Neurology (A.K.-W.), Jagiellonian University, Krakow; the Department of Neurodegenerative Disorders (M.B.), Medical Research Centre, Polish Academy of Sciences, Warsaw; the Department of Neurology (K.C.), Central Hospital of the Ministry of Interior and Administration, Warsaw, Poland; the Departments of Clinical Sciences and Neurology (A.P.), Lund University; the Department of Neurology (A.P.), Skåne University Hospital, Sweden; the Research Institute for Diseases of Old Age, Graduate School of Medicine (M.F., N.H.), Juntendo University, Tokyo, Japan; the Departments of Pathology and Laboratory Medicine (J.E.P.) and Neurology (R.C.P., B.F.B.), Mayo Clinic, Rochester, MN; the School of Medicine and Medical Science (O.A.R.), University College Dublin, Ireland; and Mayo Graduate School (O.A.R.), Neurobiology of Disease, Jacksonville, FL.

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http://dx.doi.org/10.1212/WNL.0000000000002170DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4676755PMC
December 2015

Role for the microtubule-associated protein tau variant p.A152T in risk of α-synucleinopathies.

Neurology 2015 Nov 2;85(19):1680-6. Epub 2015 Sep 2.

From the Departments of Neuroscience (C.L., K.O., O.L.-B., A.I.S.-O., R.L.W., S.R., M.E.M., P.J.M., R.R., N.E.-T., D.W.D., O.A.R.), Neurology (S.F., N.E.-T., N.R.G.-R., R.J.U., Z.K.W.), and Psychiatry and Psychology (T.J.F.), Division of Biomedical Statistics and Informatics (M.G.H.), and Mayo Graduate School (P.J.M., O.A.R.), Mayo Clinic, Jacksonville, FL; Dublin Neurological Institute at the Mater Misericordiae University Hospital (A.M., T.L.), Conway; Institute of Biomolecular & Biomedical Research (A.M., T.L.), University College Dublin, Ireland; Department of Clinical Sciences (A.P.), Lund University, and Department of Neurology, Skåne University Hospital, Sweden; Department of Neurology (J.S., G.O.), Medical University of Silesia, Katowice; Department of Neurology (M.R., A.K.-W.), Jagiellonian University, Krakow; Department of Neurodegenerative Disorders (M.B.), Medical Research Centre, Polish Academy of Sciences, Warsaw; Department of Neurology (K.C.), Central Hospital of the Ministry of Interior and Administration, Warsaw, Poland; Lviv Regional Clinical Hospital (Y.S.), Ukraine; Department of Neurology and School of Medicine (I.R.), Central European Institute of Technology, Masaryk University, Brno, Czech Republic; Departments of Neurology (A.H., J.E.A., B.F.B., R.C.P.) and Pathology and Laboratory Medicine (J.E.P.), Mayo Clinic, Rochester, MN; Department of Neurology (D.M.M.), NorthShore University Health System, Evanston, IL; and Department of Neurology (C.H.A.), Mayo Clinic, Scottsdale, AZ.

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http://dx.doi.org/10.1212/WNL.0000000000001946DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4653108PMC
November 2015

A Novel Tau Mutation in Exon 12, p.Q336H, Causes Hereditary Pick Disease.

J Neuropathol Exp Neurol 2015 Nov;74(11):1042-52

From the Departments of Neurology (PT, ZKW), Neuroscience (MD, KMH, W-LL, MS-C, YC, RR, OAR, DWD), and Psychiatry and Psychology (OP), Mayo Clinic Florida, Jacksonville, Florida.

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http://dx.doi.org/10.1097/NEN.0000000000000248DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4607649PMC
November 2015

A commentary on fine mapping and resequencing of the PARK16 locus in Parkinson's disease.

J Hum Genet 2015 Aug 2;60(8):405-6. Epub 2015 Jul 2.

Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.

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http://dx.doi.org/10.1038/jhg.2015.76DOI Listing
August 2015

CHCHD2 and Parkinson's disease.

Lancet Neurol 2015 Jul;14(7):679

Department of Neuroscience, Mayo Clinic Jacksonville, Jacksonville, FL, USA.

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http://dx.doi.org/10.1016/S1474-4422(15)00095-2DOI Listing
July 2015

TREM2 R47H variant and risk of essential tremor: a cross-sectional international multicenter study.

Parkinsonism Relat Disord 2015 Mar 24;21(3):306-9. Epub 2014 Dec 24.

Neurogenetics Laboratory, Division of Neurosciences, Center for Applied Medical Research, University of Navarra (CIMA), Pamplona, Spain; Department of Neurology, Clínica Universidad de Navarra, University of Navarra School of Medicine, Pamplona, Spain; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, CIBERNED, Instituto de Salud Carlos III, Madrid, Spain; Department of Neurology, Hospital Universitari Mutua de Terrassa, Terrassa, Barcelona, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.parkreldis.2014.12.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4408541PMC
March 2015

PARK10 is a major locus for sporadic neuropathologically confirmed Parkinson disease.

Neurology 2015 Mar 6;84(10):972-80. Epub 2015 Feb 6.

From the John P. Hussman Institute for Human Genomics (G.W.B., W.K.S., E.R.M., K.N., L.W., D.M.D., M.A.P.-V., J.M.V.) and University of Miami Brain Endowment Bank (D.C.M.), Miller School of Medicine, University of Miami, FL; Departments of Neuroscience (D.W.D., O.A.R.) and Neurology (Z.K.W.), Mayo Clinic Florida, Jacksonville; Department of Pathology & Laboratory Medicine (G.S., J.Q.T., V.M.V.D., H.I.H.), Perelman School of Medicine, Center for Neurodegenerative Disease Research, University of Pennsylvania, Philadelphia; Group Health Research Institute (E.B.L.), Seattle, WA; Departments of Psychiatry, and Genetics and Genomic Sciences (J.D.B.), Mount Sinai School of Medicine, New York, NY; Arizona Alzheimer's Consortium (T.G.B.), Phoenix; Sun Health Research Institute (T.G.B.), Sun City, AZ; Division of Neuropathology, Department of Pathology (J.C.T., O.P.), and Department of Neurology and the Solomon H. Snyder Department of Neuroscience (T.M.D.), Johns Hopkins University School of Medicine, Baltimore, MD; Kubik Laboratory for Neuropathology (M.P.F.), Massachusetts General Hospital and Harvard Medical School, Charlestown, MA; Department of Pathology and Laboratory Medicine, Indiana Alzheimer Disease Center (B.G.), and Department of Medical and Molecular Genetics (T.M.F.), Indiana University School of Medicine, Indianapolis; Departments of Neurology (L.S.H., K.M.) and Psychiatry (K.M.), Gertrude H. Sergievsky Center, and Taub Institute for Research on Alzheimer's Disease and the Aging Brain, New York; Department of Pathology and Cell Biology (J.P.V.), Taub Institute for Research on Alzheimer's Disease and the Aging Brain, New York, NY; The Parkinson's Institute (S.M.G.), Sunnyvale, CA; Departments of Pathology and Laboratory Medicine (Neuropathology) and Neurology (H.V.V.), David Geffen School of Medicine at University of California Los Angeles; Department of Pathology (T.J.M.), University of Washington School of Medicine, Seattle; VA Puget Sound Health Care System (

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http://www.neurology.org/content/early/2015/02/06/WNL.000000
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http://www.neurology.org/cgi/doi/10.1212/WNL.000000000000133
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http://dx.doi.org/10.1212/WNL.0000000000001332DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4352096PMC
March 2015

Linking the VPS35 and EIF4G1 pathways in Parkinson's disease.

Neuron 2015 Jan;85(1):1-3

Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2014.12.045DOI Listing
January 2015