Publications by authors named "Owain W Howell"

27Publications

B cell rich meningeal inflammation associates with increased spinal cord pathology in multiple sclerosis.

Brain Pathol 2020 07 26;30(4):779-793. Epub 2020 Apr 26.

Department of Brain Sciences, Faculty of Medicine, Imperial College, London, UK.

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http://dx.doi.org/10.1111/bpa.12841DOI Listing
July 2020

Localization of sterols and oxysterols in mouse brain reveals distinct spatial cholesterol metabolism.

Proc Natl Acad Sci U S A 2020 03 4;117(11):5749-5760. Epub 2020 Mar 4.

Institute of Life Science, Swansea University Medical School, SA2 8PP Swansea, Wales, United Kingdom;

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http://dx.doi.org/10.1073/pnas.1917421117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7084107PMC
March 2020

Using biomarkers to predict clinical outcomes in multiple sclerosis.

Pract Neurol 2019 Aug 26;19(4):342-349. Epub 2019 Jun 26.

Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK

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http://dx.doi.org/10.1136/practneurol-2018-002000DOI Listing
August 2019

Meningeal inflammation and cortical demyelination in acute multiple sclerosis.

Ann Neurol 2018 12 30;84(6):829-842. Epub 2018 Nov 30.

Institute of Life Sciences, Swansea University Medical School, Swansea, United Kingdom.

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http://dx.doi.org/10.1002/ana.25365DOI Listing
December 2018

Tissue microarray methodology identifies complement pathway activation and dysregulation in progressive multiple sclerosis.

Brain Pathol 2018 07 30;28(4):507-520. Epub 2017 Jul 30.

Division of Infection and Immunity, Henry Wellcome Building, Cardiff University, Cardiff, CF14 4XW, United Kingdom.

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http://dx.doi.org/10.1111/bpa.12546DOI Listing
July 2018

Complement is activated in progressive multiple sclerosis cortical grey matter lesions.

J Neuroinflammation 2016 06 22;13(1):161. Epub 2016 Jun 22.

Institute of Life Sciences, Swansea University School of Medicine, Swansea, SA2 8PP, UK.

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http://dx.doi.org/10.1186/s12974-016-0611-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4918026PMC
June 2016

Extensive grey matter pathology in the cerebellum in multiple sclerosis is linked to inflammation in the subarachnoid space.

Neuropathol Appl Neurobiol 2015 Oct 2;41(6):798-813. Epub 2015 May 2.

Wolfson Neuroscience Laboratories, Centre for Neuroinflammation and Neurodegeneration, Division of Brain Sciences, Imperial College London, London, UK.

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http://dx.doi.org/10.1111/nan.12199DOI Listing
October 2015

Complement activation in multiple sclerosis plaques: an immunohistochemical analysis.

Acta Neuropathol Commun 2014 May 9;2:53. Epub 2014 May 9.

Institute of Infection and Immunity, School of Medicine, Cardiff University, Cardiff, UK.

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http://dx.doi.org/10.1186/2051-5960-2-53DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4048455PMC
May 2014

Cortical grey matter demyelination can be induced by elevated pro-inflammatory cytokines in the subarachnoid space of MOG-immunized rats.

Brain 2013 Dec 30;136(Pt 12):3596-608. Epub 2013 Oct 30.

1 Wolfson Neuroscience Laboratories, Division of Brain Sciences, Faculty of Medicine, Imperial College London, UK.

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http://dx.doi.org/10.1093/brain/awt279DOI Listing
December 2013

Polymorphisms in neuropsychiatric and neuroinflammatory disorders and the role of next generation sequencing in early diagnosis and treatment.

Adv Protein Chem Struct Biol 2012 ;89:85-116

Institute of Life Science, College of Medicine, Swansea University, Swansea, UK.

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http://dx.doi.org/10.1016/B978-0-12-394287-6.00004-5DOI Listing
November 2013

Meningeal inflammation plays a role in the pathology of primary progressive multiple sclerosis.

Brain 2012 Oct 20;135(Pt 10):2925-37. Epub 2012 Aug 20.

Wolfson Neuroscience Laboratories, Centre for Neuroscience, Imperial College Faculty of Medicine, Hammersmith Hospital, London W12 0NN, UK.

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http://dx.doi.org/10.1093/brain/aws189DOI Listing
October 2012

Meningeal inflammation is widespread and linked to cortical pathology in multiple sclerosis.

Brain 2011 Sep 11;134(Pt 9):2755-71. Epub 2011 Aug 11.

Centre for Neuroscience, Division of Experimental Medicine, Imperial College Faculty of Medicine, Hammersmith Hospital Campus, Burlington Danes Building, Du Cane Road, London W12 0NN, UK.

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http://dx.doi.org/10.1093/brain/awr182DOI Listing
September 2011

A Gradient of neuronal loss and meningeal inflammation in multiple sclerosis.

Ann Neurol 2010 Oct;68(4):477-93

Centre for Neuroscience, Imperial College, Faculty of Medicine, London, United Kingdom.

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http://dx.doi.org/10.1002/ana.22230DOI Listing
October 2010

Activated microglia mediate axoglial disruption that contributes to axonal injury in multiple sclerosis.

J Neuropathol Exp Neurol 2010 Oct;69(10):1017-1033

Centre for Neuroscience, Division of Experimental Medicine, Imperial College Faculty of Medicine, Hammersmith Hospital Campus, London W12 0NN.

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http://dx.doi.org/10.1097/NEN.0b013e3181f3a5b1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4335193PMC
October 2010

Two binding sites for [3H]PBR28 in human brain: implications for TSPO PET imaging of neuroinflammation.

J Cereb Blood Flow Metab 2010 Sep 28;30(9):1608-18. Epub 2010 Apr 28.

Department of Experimental Medicine and Toxicology, Imperial College London, Hammersmith Hospital, London, UK.

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http://dx.doi.org/10.1038/jcbfm.2010.63DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2949260PMC
September 2010

NPY mediates basal and seizure-induced proliferation in the subcallosal zone.

Neuroreport 2007 Jul;18(10):1005-8

Division of Clinical Neurosciences, University of Southampton, UK.

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http://dx.doi.org/10.1097/WNR.0b013e32815277abDOI Listing
July 2007

Neuropeptide Y is important for basal and seizure-induced precursor cell proliferation in the hippocampus.

Neurobiol Dis 2007 Apr 30;26(1):174-88. Epub 2006 Dec 30.

Division of Clinical Neurosciences, University of Southampton, Room LD70, D Level, South Academic Block, Southampton General Hospital, Southampton SO16 6YD, UK.

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http://dx.doi.org/10.1016/j.nbd.2006.12.014DOI Listing
April 2007

Neuropeptide Y is neuroproliferative for post-natal hippocampal precursor cells.

J Neurochem 2003 Aug;86(3):646-59

Division of Clinical Neurosciences, University of Southampton, Southampton, UK CNRRR, Helen Hayes Hospital, West Haverstraw, New York, USA.

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http://dx.doi.org/10.1046/j.1471-4159.2003.01895.xDOI Listing
August 2003