Ovidio Bussolati

Ovidio Bussolati

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Ovidio Bussolati

Ovidio Bussolati

Publications by authors named "Ovidio Bussolati"

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γ-Glutamyltransferase enzyme activity of cancer cells modulates L-γ-glutamyl-p-nitroanilide (GPNA) cytotoxicity.

Sci Rep 2019 Jan 29;9(1):891. Epub 2019 Jan 29.

Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Via Roma 55, 56126, Pisa, Italy.

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http://dx.doi.org/10.1038/s41598-018-37385-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351548PMC
January 2019

GPNA inhibits the sodium-independent transport system L for neutral amino acids.

Amino Acids 2017 08 17;49(8):1365-1372. Epub 2017 May 17.

Laboratory of General Pathology, Department of Medicine and Surgery, University of Parma, Via Volturno 39, 43125, Parma, Italy.

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http://dx.doi.org/10.1007/s00726-017-2436-zDOI Listing
August 2017

The potential of inhibiting glutamine uptake as a therapeutic target for multiple myeloma.

Expert Opin Ther Targets 2017 03 18;21(3):231-234. Epub 2017 Jan 18.

b Department of Biomedical , Biotechnological and Translational Sciences, University of Parma , Parma , Italy.

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http://dx.doi.org/10.1080/14728222.2017.1279148DOI Listing
March 2017

Toxicity determinants of multi-walled carbon nanotubes: The relationship between functionalization and agglomeration.

Toxicol Rep 2016 19;3:230-243. Epub 2016 Jan 19.

Research Unit of Advanced, Composite, Nano-Materials and Nanotechnology, Department of Materials Science and Engineering, School of Chemical Engineering, National Technical University of Athens, GR-157 80 Athens, Greece.

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http://dx.doi.org/10.1016/j.toxrep.2016.01.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5615827PMC
January 2016

Imogolite: an aluminosilicate nanotube endowed with low cytotoxicity and genotoxicity.

Chem Res Toxicol 2014 Jul 16;27(7):1142-54. Epub 2014 Jun 16.

Department of Biomedical, Biotechnological and Translational Sciences (SBiBiT) and ‡Department of Clinical and Experimental Medicine, University of Parma , 43125 Parma, Italy.

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http://pubs.acs.org/doi/10.1021/tx500002d
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http://dx.doi.org/10.1021/tx500002dDOI Listing
July 2014

Changes in the expression of the glutamate transporter EAAT3/EAAC1 in health and disease.

Cell Mol Life Sci 2014 Jun 26;71(11):2001-15. Epub 2013 Oct 26.

Unit of General Pathology, Department of Biomedical, Biotechnological and Translational Sciences (SBiBiT), University of Parma, Via Volturno 39, 43125, Parma, Italy.

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http://dx.doi.org/10.1007/s00018-013-1484-0DOI Listing
June 2014

Oxidative stress induced by copper and iron complexes with 8-hydroxyquinoline derivatives causes paraptotic death of HeLa cancer cells.

Mol Pharm 2014 Apr 12;11(4):1151-63. Epub 2014 Mar 12.

Dipartimento di Chimica, Università degli Studi di Parma , Viale delle Scienze 17/A, 43123 Parma, Italy.

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http://dx.doi.org/10.1021/mp400592nDOI Listing
April 2014

Asparagine levels in the bone marrow of patients with acute lymphoblastic leukemia during asparaginase therapy.

Pediatr Blood Cancer 2013 Nov 30;60(11):1915. Epub 2013 Jul 30.

Unit of General Pathology, Department of Biomedical, Biotechnological and Translational Sciences (SBiBiT), University of Parma, Parma, Italy.

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http://dx.doi.org/10.1002/pbc.24663DOI Listing
November 2013

Glutamine stimulates mTORC1 independent of the cell content of essential amino acids.

Amino Acids 2012 Dec 8;43(6):2561-7. Epub 2012 May 8.

Unit of General and Clinical Pathology, Department of Experimental Medicine, University of Parma, Via Volturno 39, 43125, Parma, Italy.

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http://link.springer.com/content/pdf/10.1007/s00726-012-1312
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http://link.springer.com/10.1007/s00726-012-1312-0
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http://dx.doi.org/10.1007/s00726-012-1312-0DOI Listing
December 2012

Copper-dependent cytotoxicity of 8-hydroxyquinoline derivatives correlates with their hydrophobicity and does not require caspase activation.

J Med Chem 2012 Dec 3;55(23):10448-59. Epub 2012 Dec 3.

Dipartimento di Chimica, Università degli Studi di Parma, Viale delle Scienze 17/A, 43123 Parma, Italy.

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http://pubs.acs.org/doi/10.1021/jm301053a
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http://dx.doi.org/10.1021/jm301053aDOI Listing
December 2012

Towards a metabolic therapy of cancer?

Acta Biomed 2012 Dec;83(3):168-76

Unit of General Pathology, Department of Biomedical, Biotechnological and Translational Sciences, University of Parma, Italy.

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December 2012

The non-proteinogenic amino acids L-methionine sulfoximine and DL-phosphinothricin activate mTOR.

Amino Acids 2012 Jun 17;42(6):2507-12. Epub 2011 Jul 17.

Unit of General and Clinical Pathology, Department of Experimental Medicine, University of Parma, Via Volturno 39, 43125, Parma, Italy.

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http://dx.doi.org/10.1007/s00726-011-0981-4DOI Listing
June 2012

Radiochemical high-performance liquid chromatography detection of arginine metabolism in human endothelial cells.

Anal Biochem 2012 May 28;424(2):156-61. Epub 2012 Feb 28.

Dipartimento di Medicina Sperimentale, Sezione di Patologia Generale e Clinica, Università degli Studi di Parma, 43125 Parma, Italy.

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http://linkinghub.elsevier.com/retrieve/pii/S000326971200132
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http://dx.doi.org/10.1016/j.ab.2012.02.023DOI Listing
May 2012

Impaired phagocytosis in macrophages from patients affected by lysinuric protein intolerance.

Mol Genet Metab 2012 Apr 17;105(4):585-9. Epub 2012 Jan 17.

Dipartimento di Medicina Sperimentale, Sezione di Patologia Generale e Clinica, Università degli Studi di Parma, Parma, Italy.

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http://dx.doi.org/10.1016/j.ymgme.2012.01.008DOI Listing
April 2012

Expanding targets for a metabolic therapy of cancer: L-asparaginase.

Recent Pat Anticancer Drug Discov 2012 Jan;7(1):4-13

Department of Experimental Medicine, Section of General Pathology, University of Pavia, Via Ferrata, 1, 27100 Pavia, Italy.

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January 2012

Arginine transport in human monocytic leukemia THP-1 cells during macrophage differentiation.

J Leukoc Biol 2011 Aug 17;90(2):293-303. Epub 2011 May 17.

Dipartimento di Medicina Sperimentale, Università di Parma, Parma, Italy.

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http://dx.doi.org/10.1189/jlb.0910510DOI Listing
August 2011

Copper binding agents acting as copper ionophores lead to caspase inhibition and paraptotic cell death in human cancer cells.

J Am Chem Soc 2011 Apr 31;133(16):6235-42. Epub 2011 Mar 31.

Dipartimento di Medicina Sperimentale, Sezione di Patologia Generale e Clinica, Via Volturno 39, 43100 Parma, Italy.

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http://dx.doi.org/10.1021/ja109413cDOI Listing
April 2011

Platelet gel in the treatment of cutaneous ulcers: the experience of the Immunohaematology and Transfusion Centre of Parma.

Blood Transfus 2010 Oct;8(4):237-47

U.O. Immunoematologia e Medicina Trasfusionale, Dipartimento di Patologia e Medicina di Laboratorio, Azienda Ospedaliero-Universitaria di Parma, Via Gramsci 14, Parma, Italy.

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http://dx.doi.org/10.2450/2009.0118-09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2957488PMC
October 2010

Regulation of arginine transport and metabolism by protein kinase Calpha in endothelial cells: stimulation of CAT2 transporters and arginase activity.

J Mol Cell Cardiol 2010 Aug 26;49(2):260-70. Epub 2010 Apr 26.

Dipartimento di Medicina Sperimentale, Università degli Studi di Parma, 43100 Parma, Italy.

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http://dx.doi.org/10.1016/j.yjmcc.2010.04.007DOI Listing
August 2010

Arginine transport in human erythroid cells: discrimination of CAT1 and 4F2hc/y+LAT2 roles.

Pflugers Arch 2009 Oct 28;458(6):1163-73. Epub 2009 Jun 28.

Unit of General and Clinical Pathology, Department of Experimental Medicine, University of Parma, Via Volturno, 39-43125, Parma, Italy.

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http://dx.doi.org/10.1007/s00424-009-0692-9DOI Listing
October 2009

The ATRA-dependent overexpression of the glutamate transporter EAAC1 requires RARbeta induction.

Biochim Biophys Acta 2009 Sep 18;1788(9):1861-8. Epub 2009 May 18.

Department of Experimental Medicine, Unit of General and Clinical Pathology, University of Parma, via Volturno 39, 43100 Parma, Italy.

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http://dx.doi.org/10.1016/j.bbamem.2009.05.005DOI Listing
September 2009

Treatment of chronic venous leg ulcers by platelet gel.

Dermatol Ther 2008 Jul;21 Suppl 1:S13-7

Section of Dermatology, Department of Surgical Sciences, Parma University, Parma, Italy.

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http://dx.doi.org/10.1111/j.1529-8019.2008.00196.xDOI Listing
July 2008

In human endothelial cells rapamycin causes mTORC2 inhibition and impairs cell viability and function.

Cardiovasc Res 2008 Jun 4;78(3):563-71. Epub 2008 Feb 4.

Department of Experimental Medicine, Unit of General and Clinical Pathology, University of Parma, Via Volturno 39, 43100 Parma, Italy.

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http://dx.doi.org/10.1093/cvr/cvn024DOI Listing
June 2008

Non-functionalized multi-walled carbon nanotubes alter the paracellular permeability of human airway epithelial cells.

Toxicol Lett 2008 May 4;178(2):95-102. Epub 2008 Mar 4.

Department of Experimental Medicine, Unit of General and Clinical Pathology, University of Parma, via Volturno 14, 43100 Parma, Italy.

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http://dx.doi.org/10.1016/j.toxlet.2008.02.007DOI Listing
May 2008

Alveolar macrophages from normal subjects lack the NOS-related system y+ for arginine transport.

Am J Respir Cell Mol Biol 2007 Jul 15;37(1):105-12. Epub 2007 Mar 15.

Sezione di Patologia Generale e Clinica, Dipartimento di Medicina Sperimentale, Università di Parma, Via Volturno 39, 43100 Parma, Italy.

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http://dx.doi.org/10.1165/rcmb.2006-0262OCDOI Listing
July 2007

Rapamycin stimulates arginine influx through CAT2 transporters in human endothelial cells.

Biochim Biophys Acta 2007 Jun 24;1768(6):1479-87. Epub 2007 Feb 24.

Department of Experimental Medicine, Unit of General and Clinical Pathology, University of Parma, via Volturno 39, 43100 Parma, Italy.

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http://linkinghub.elsevier.com/retrieve/pii/S000527360700065
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http://dx.doi.org/10.1016/j.bbamem.2007.02.016DOI Listing
June 2007

Thioamido coordination in a thioxo-1,2,4-triazole copper(II) complex enhances nonapoptotic programmed cell death associated with copper accumulation and oxidative stress in human cancer cells.

J Med Chem 2007 Apr 21;50(8):1916-24. Epub 2007 Mar 21.

Dipartimento di Chimica Generale ed Inorganica, Chimica Analitica, Chimica Fisica, Università degli Studi di Parma, Viale G.P. Usberti 17/A, 43100 Parma, Italy.

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http://dx.doi.org/10.1021/jm061174fDOI Listing
April 2007

Amino acid starvation induces the SNAT2 neutral amino acid transporter by a mechanism that involves eukaryotic initiation factor 2alpha phosphorylation and cap-independent translation.

J Biol Chem 2006 Jun 18;281(26):17929-40. Epub 2006 Apr 18.

Departments of Nutrition and Biochemistry, Case Western Reserve University School of Medicine, 10900 Euclid Avenue, Cleveland, OH 44106, USA.

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http://dx.doi.org/10.1074/jbc.M600341200DOI Listing
June 2006

PKC-dependent stimulation of EAAT3 glutamate transporter does not require the integrity of actin cytoskeleton.

Neurochem Int 2006 Apr 18;48(5):341-9. Epub 2006 Jan 18.

Unit of General and Clinical Pathology, Department of Experimental Medicine, University of Parma, Italy.

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http://dx.doi.org/10.1016/j.neuint.2005.11.013DOI Listing
April 2006

Inhibition of glutamine synthetase triggers apoptosis in asparaginase-resistant cells.

Cell Physiol Biochem 2005 ;15(6):281-92

Units of General and Clinical Pathology, Department of Experimental Medicine, Universita degli Studi di Parma, Parma, Italy.

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http://dx.doi.org/10.1159/000087238DOI Listing
November 2005

SNAT2 silencing prevents the osmotic induction of transport system A and hinders cell recovery from hypertonic stress.

FEBS Lett 2005 Jun;579(16):3376-80

Sezione di Patologia Generale e Clinica, Dipartimento di Medicina, Sperimentale, Università degli Studi di Parma, Via Volturno 39, 43100 Parma, Italy.

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http://dx.doi.org/10.1016/j.febslet.2005.05.002DOI Listing
June 2005

The transport of cationic amino acids in human airway cells: expression of system y+L activity and transepithelial delivery of NOS inhibitors.

FASEB J 2005 May 3;19(7):810-2. Epub 2005 Mar 3.

Sezione di Patologia Generale e Clinica, Dipartimento di Medicina Sperimentale, Università degli Studi di Parma, Parma, Italy.

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http://dx.doi.org/10.1096/fj.04-2924fjeDOI Listing
May 2005

The synthesis of SNAT2 transporters is required for the hypertonic stimulation of system A transport activity.

Biochim Biophys Acta 2004 Dec;1667(2):157-66

Dipartimento di Medicina Sperimentale, Sezione di Patologia Generale e Clinica, Università degli Studi di Parma, Via Volturno 39, 43100 Parma, Italy.

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http://dx.doi.org/10.1016/j.bbamem.2004.09.012DOI Listing
December 2004

The stimulation of arginine transport by TNFalpha in human endothelial cells depends on NF-kappaB activation.

Biochim Biophys Acta 2004 Jul;1664(1):45-52

Dipartimento di Medicina Sperimentale, Sezione di Patologia Generale e Clinica, Università degli Studi di Parma, Via Volturno, 39 Parma 43100, Italy.

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http://linkinghub.elsevier.com/retrieve/pii/S000527360400096
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http://dx.doi.org/10.1016/j.bbamem.2004.04.001DOI Listing
July 2004

INFgamma stimulates arginine transport through system y+L in human monocytes.

FEBS Lett 2004 Jul;571(1-3):177-81

Dipartimento di Medicina Sperimentale, Sezione di Patologia Generale e Clinica, Plesso Biotecnologico Integrato, Università degli Studi di Parma, Via Volturno 39, 43100 Parma, Italy.

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http://dx.doi.org/10.1016/j.febslet.2004.06.086DOI Listing
July 2004

Endothelial cell injury induced by preservation solutions: a confocal microscopy study.

Ann Thorac Surg 2002 May;73(5):1606-14; discussion 1614-5

Department of Cardiac Surgery, Centro Cardiologico-Fondazione I Monzino IRCCS, University of Milan, Italy.

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May 2002

Two-way arginine transport in human endothelial cells: TNF-alpha stimulation is restricted to system y(+).

Am J Physiol Cell Physiol 2002 Jan;282(1):C134-43

Dipartimento di Medicina Sperimentale, Sezione di Patologia Generale e Clinica, Università degli Studi di Parma, 43100 Parma, Italy.

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http://dx.doi.org/10.1152/ajpcell.2002.282.1.C134DOI Listing
January 2002