Publications by authors named "Ousmane Abdoulaye"

3 Publications

  • Page 1 of 1

Laboratory organisation and management of SARS-CoV-2 infection in Niger, West Africa.

Afr J Lab Med 2020 21;9(1):1308. Epub 2020 Dec 21.

Faculté des Sciences de la Santé, Université Abdou Moumouni, Niamey, Niger.

Background: As the coronavirus disease 2019 (COVID-19) pandemic unfolds, laboratory services have been identified as key to its containment. This article outlines the laboratory organisation and management and control interventions in Niger.

Intervention: The capitol city of Niger, Niamey, adopted a 'National COVID-19 Emergency Preparedness and Response Plan' to strengthen the preparedness of the country for the detection of severe acute respiratory syndrome coronavirus-2. Laboratory training and diagnostic capacity building were supported by existing active clinical and research laboratories for more rapid and practicable responses. The National Reference Laboratory for Respiratory Viruses located at the was designated as the reference centre for COVID-19 testing. The national plan for COVID-19 testing is being gradually adopted in other regions of the country in response to the rapidly evolving COVID-19 emergency and to ensure a more rapid turn-around time.

Lessons Learnt: After the decentralisation of COVID-19 testing to other regions of the country, turn-around times were reduced from 48-72 h to 12-24 h. Reducing turn-around times allowed Niger to reduce the length of patients' stays in hospitals and isolation facilities. Shortages in testing capacity must be anticipated and addressed. In an effort to reduce risk of shortages and increase availability of reagents and consumables, Niamey diversified real-time reverse transcriptase-polymerase chain reaction kits for severe acute respiratory syndrome coronavirus-2 detection.

Recommendations: Continued investment in training programmes and laboratory strategy is needed in order to strengthen Niger's laboratory capacity against the outbreak.
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December 2020

[Epidemiological, clinical and evolutionary profile of patients with tuberculosis at the Regional Hospital of Maradi, Republic of the Niger].

Pan Afr Med J 2019 17;33:120. Epub 2019 Jun 17.

Service de Médecine Interne, Hôpital Général de Référence Niamey, Faculté des Sciences de la Santé de l'UAM de Niamey, Niamey, Niger.

Introduction: This study aimed to describe the epidemiological, clinical and evolutionary profile of patients treated for tuberculosis at the Regional Hospital of Maradi.

Methods: We conducted a retrospective, descriptive and analytical study of data from the medical records of patients treated for tuberculosis from 1 January 2015 to 31 December 2017.

Results: A total of 595 patients were followed (406 men, 68.24%, and 189 women, 31.76%) with a prevalence of 27,71%. The average age of patients was 42.3 ranging from 13 months to 85 years; 70.5% of these patients were from urban areas. Merchants represented 36.9% of the cases. Bacterial test was positive in 64.7% of cases. Functional signs included: coughing (99.5%), fever (79.5%), and chest pain. Pulmonary tuberculosis represented 78.7% of cases. Therapy was effective in 81.28% of cases. HIV prevalence was 13.6%, lethality 10.42% (40.4% of patients died from TB/HIV co-infection).

Conclusion: Tuberculosis is a scourge in low-income countries, with 10.42% of deaths. HIV/AIDS infection has negatively contributed to these deaths during the study period. The search for comorbidities in any patient with tuberculosis should be systematic in order to improve their global management.
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September 2019

[Epidemiological and bacteriological features of surgical site infections (ISO) in the Division of Surgery at the Niamey National Hospital (HNN)].

Pan Afr Med J 2018 14;31:33. Epub 2018 Sep 14.

Faculté de Sciences de la Santé, Laboratoire de Bactériologie Virologie, Université Abdou Moumouni de Niamey, Niger.

This study aims to evaluate the epidemiological and bacteriological features of bacterial strains isolated from surgical site infections (ISO) at the Niamey National Hospital. We conducted a retrospective, descriptive study over a period of 24 months. All strains isolated from bacteriological samplings from patients with a surgical site infection have been identified and tested for antibiotic sensitivity according to conventional methods. The bacteriological analysis allowed the isolation of 126 bacterial strains with a predominance of S.aureus (n=39, 31%) followed by Escherichia coli (n=29, 23%) and Pseudomonas aeruginosa (n=12, 9.5%). The strains of Escherichia coli were 100% sensitive to imipenem. They showed marked ampicillin, amoxicillin, clavulanic acid and ticarcillin resistance. They had variable resistance to aminoglycoside antibiotics (62% to gentamycin, and 78% to amikacin) and to fluoroquinolones (nalidixic acid 74%, pefloxacine 33%, ofloxacin 69%, ciprofloxacin 61%). All enterobacterial isolates were sensitive to imipenem. The strains of S.aureus showed resistance to penicillin G (88.6%) and oxacillin (83%). They also showed resistance to vancomycin and teicoplanin (37% and 57% respectively). By contrast, they were sensitive to lincomycin and aminoglycoside antibiotics tested. In the light of these results, we believe that it will be necessary to improve prophylaxis protocol and probabilistic antibiotic therapy in the Surgical Division and to conduct periodic surveillance studies of the ISO.
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April 2019