Publications by authors named "Ouathek Ouerfelli"

53Publications

Targeting Germline- and Tumor-Associated Nucleotide Excision Repair Defects in Cancer.

Authors:
Sabine Topka Zoe Steinsnyder Vignesh Ravichandran Kaitlyn Tkachuk Yelena Kemel Chaitanya Bandlamudi Mogens Winkel Madsen Helena Furberg Ouathek Ouerfelli Charles M Rudin Gopa Iyer Steven M Lipkin Semanti Mukherjee David B Solit Michael F Berger Dean F Bajorin Jonathan E Rosenberg Barry S Taylor Elisa de Stanchina Joseph Vijai Kenneth Offit

Clin Cancer Res 2020 Nov 16. Epub 2020 Nov 16.

Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.

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November 2020

Alpha radioimmunotherapy using Ac-proteus-DOTA for solid tumors - safety at curative doses.

Authors:
Sarah M Cheal Michael R McDevitt Brian H Santich Mitesh Patel Guangbin Yang Edward K Fung Darren R Veach Meghan Bell Afruja Ahad Daniela Burnes Vargas Blesida Punzalan Naga Vara Kishore Pillarsetty Hong Xu Hong-Fen Guo Sébastien Monette Adam O Michel Alessandra Piersigilli David A Scheinberg Ouathek Ouerfelli Nai-Kong V Cheung Steven M Larson

Theranostics 2020 14;10(25):11359-11375. Epub 2020 Sep 14.

Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY.

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September 2020

A Self-Assembling and Disassembling (SADA) Bispecific Antibody (BsAb) Platform for Curative Two-step Pretargeted Radioimmunotherapy.

Authors:
Brian H Santich Sarah M Cheal Mahiuddin Ahmed Michael R McDevitt Ouathek Ouerfelli Guangbin Yang Darren R Veach Edward K Fung Mitesh Patel Daniela Burnes Vargas Aiza A Malik Hong-Fen Guo Pat B Zanzonico Sebastien Monette Adam O Michel Charles M Rudin Steven M Larson Nai K Cheung

Clin Cancer Res 2021 Jan 21;27(2):532-541. Epub 2020 Sep 21.

Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York.

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January 2021

Synthesis of the PET Tracer I-Trametinib for MAPK/ERK Kinase Distribution and Resistance Monitoring.

Authors:
Edwin C Pratt Elizabeth Isaac Evan P Stater Guangbin Yang Ouathek Ouerfelli Nagavarakishore Pillarsetty Jan Grimm

J Nucl Med 2020 Dec 22;61(12):1845-1850. Epub 2020 May 22.

Department of Pharmacology, Weill Cornell Graduate School, New York, New York

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December 2020

An -Acetylgalactosamino Dendron-Clearing Agent for High-Therapeutic-Index DOTA-Hapten Pretargeted Radioimmunotherapy.

Authors:
Sarah M Cheal Mitesh Patel Guangbin Yang Darren Veach Hong Xu Hong-Fen Guo Pat B Zanzonico Donald B Axworthy Nai-Kong V Cheung Ouathek Ouerfelli Steven M Larson

Bioconjug Chem 2020 03 10;31(3):501-506. Epub 2020 Feb 10.

Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, United States.

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March 2020

A Small-Molecule Pan-Id Antagonist Inhibits Pathologic Ocular Neovascularization.

Authors:
Paulina M Wojnarowicz Raquel Lima E Silva Masayuki Ohnaka Sang Bae Lee Yvette Chin Anita Kulukian Sung-Hee Chang Bina Desai Marta Garcia Escolano Riddhi Shah Marta Garcia-Cao Sijia Xu Rashmi Kadam Yehuda Goldgur Meredith A Miller Ouathek Ouerfelli Guangli Yang Tsutomu Arakawa Steven K Albanese William A Garland Glenn Stoller Jaideep Chaudhary Larry Norton Rajesh Kumar Soni John Philip Ronald C Hendrickson Antonio Iavarone Andrew J Dannenberg John D Chodera Nikola Pavletich Anna Lasorella Peter A Campochiaro Robert Benezra

Cell Rep 2019 10;29(1):62-75.e7

Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Electronic address:

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October 2019

The Polycomb Repressor Complex 1 Drives Double-Negative Prostate Cancer Metastasis by Coordinating Stemness and Immune Suppression.

Authors:
Wenjing Su Hyun Ho Han Yan Wang Boyu Zhang Bing Zhou Yuanming Cheng Alekya Rumandla Sreeharsha Gurrapu Goutam Chakraborty Jie Su Guangli Yang Xin Liang Guocan Wang Neal Rosen Howard I Scher Ouathek Ouerfelli Filippo G Giancotti

Cancer Cell 2019 08 18;36(2):139-155.e10. Epub 2019 Jul 18.

Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Unit 1906, PO Box 301429, Houston, TX 77054/77030-1429, USA; Department of Genitourinary Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA. Electronic address:

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August 2019

CRISPR-Cas III-A Csm6 CARF Domain Is a Ring Nuclease Triggering Stepwise cA Cleavage with ApA>p Formation Terminating RNase Activity.

Authors:
Ning Jia Roger Jones Guangli Yang Ouathek Ouerfelli Dinshaw J Patel

Mol Cell 2019 09 17;75(5):944-956.e6. Epub 2019 Jul 17.

Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Electronic address:

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September 2019

Structure and mechanism of pyrimidine-pyrimidone (6-4) photoproduct recognition by the Rad4/XPC nucleotide excision repair complex.

Authors:
Debamita Paul Hong Mu Hong Zhao Ouathek Ouerfelli Philip D Jeffrey Suse Broyde Jung-Hyun Min

Nucleic Acids Res 2019 07;47(12):6015-6028

Department of Chemistry & Biochemistry, Baylor University, Waco, TX 76798, USA.

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July 2019

Opposing reactions in coenzyme A metabolism sensitize to enzyme inhibition.

Authors:
Elaine Ballinger John Mosior Travis Hartman Kristin Burns-Huang Ben Gold Roxanne Morris Laurent Goullieux Isabelle Blanc Julien Vaubourgeix Sophie Lagrange Laurent Fraisse Stéphanie Sans Cedric Couturier Eric Bacqué Kyu Rhee Sarah M Scarry Jeffrey Aubé Guangbin Yang Ouathek Ouerfelli Dirk Schnappinger Thomas R Ioerger Curtis A Engelhart Jennifer A McConnell Kathrine McAulay Allison Fay Christine Roubert James Sacchettini Carl Nathan

Science 2019 02;363(6426)

Department of Microbiology and Immunology, Weill Cornell Medicine, New York, NY, USA.

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February 2019

BET Inhibition-Induced GSK3β Feedback Enhances Lymphoma Vulnerability to PI3K Inhibitors.

Authors:
Enrico Derenzini Patrizia Mondello Tatiana Erazo Ana Portelinha Yuxuan Liu Mary Scallion Zahra Asgari John Philip Patrick Hilden Debora Valli Alessandra Rossi Hakim Djaballah Ouathek Ouerfelli Elisa de Stanchina Venkatraman E Seshan Ronald C Hendrickson Anas Younes

Cell Rep 2018 08;24(8):2155-2166

Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Lymphoma Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA. Electronic address:

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August 2018

Targetable Clinical Nanoparticles for Precision Cancer Therapy Based on Disease-Specific Molecular Inflection Points.

Authors:
Charalambos Kaittanis Alexander Bolaender Barney Yoo Nilesh Shah Ouathek Ouerfelli Jan Grimm

Nano Lett 2017 11 23;17(11):7160-7168. Epub 2017 Oct 23.

Departments of Pharmacology and Radiology, Weill Cornell Medical College , New York, New York 10065, United States.

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November 2017

Distinct Spatiotemporal Dynamics of Peptidoglycan Synthesis between and .

Authors:
Helene Botella Guangli Yang Ouathek Ouerfelli Sabine Ehrt Carl F Nathan Julien Vaubourgeix

mBio 2017 09 12;8(5). Epub 2017 Sep 12.

Department of Microbiology and Immunology, Weill Cornell Medical College, New York, New York, USA

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September 2017

Increased Airport Scrutiny by the Transportation Security Administration of a Patient-Passenger Carrying Ammonium Lactate-Containing Moisturizer.

Authors:
Allison Zarbo Ouathek Ouerfelli Mark Klang Mario E Lacouture

JAMA Dermatol 2016 09;152(9):1054-5

Dermatology Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York.

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September 2016

Reply to "Uveal melanoma cells are resistant to EZH2 inhibition regardless of BAP1 status".

Authors:
Lindsay M LaFave Wendy Béguelin Richard Koche Matt Teater Barbara Spitzer Alan Chramiec Efthymia Papalexi Matthew D Keller Todd Hricik Katerina Konstantinoff Jean-Baptiste Micol Benjamin Durham Sarah K Knutson John E Campbell Gil Blum Xinxu Shi Emma H Doud Andrei V Krivtsov Young Rock Chung Inna Khodos Elisa de Stanchina Ouathek Ouerfelli Prasad S Adusumilli Paul M Thomas Neil L Kelleher Minkui Luo Heike Keilhack Omar Abdel-Wahab Ari Melnick Scott A Armstrong Ross L Levine

Nat Med 2016 06;22(6):578-9

Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA.

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June 2016

Proteasome Addiction Defined in Ewing Sarcoma Is Effectively Targeted by a Novel Class of 19S Proteasome Inhibitors.

Authors:
Neerav Shukla Romel Somwar Roger S Smith Sri Ambati Stanley Munoz Melinda Merchant Padraig D'Arcy Xin Wang Rachel Kobos Christophe Antczak Bhavneet Bhinder David Shum Constantin Radu Guangbin Yang Barry S Taylor Charlotte K Y Ng Britta Weigelt Inna Khodos Elisa de Stanchina Jorge S Reis-Filho Ouathek Ouerfelli Stig Linder Hakim Djaballah Marc Ladanyi

Cancer Res 2016 08 2;76(15):4525-34. Epub 2016 Jun 2.

Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York. Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York.

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August 2016

A Phase I Study of Unimolecular Pentavalent (Globo-H-GM2-sTn-TF-Tn) Immunization of Patients with Epithelial Ovarian, Fallopian Tube, or Peritoneal Cancer in First Remission.

Authors:
Roisin E O'Cearbhaill Govind Ragupathi Jianglong Zhu Qian Wan Svetlana Mironov Guangbin Yang Maria K Spassova Alexia Iasonos Sara Kravetz Ouathek Ouerfelli David R Spriggs Samuel J Danishefsky Paul J Sabbatini

Cancers (Basel) 2016 Apr 22;8(4). Epub 2016 Apr 22.

Gynecologic Medical Oncology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

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April 2016

Isocitrate dehydrogenase 1 mutations prime the all-trans retinoic acid myeloid differentiation pathway in acute myeloid leukemia.

Authors:
Héléna Boutzen Estelle Saland Clément Larrue Fabienne de Toni Lara Gales Florence A Castelli Mathilde Cathebas Sonia Zaghdoudi Lucille Stuani Tony Kaoma Romain Riscal Guangli Yang Pierre Hirsch Marion David Véronique De Mas-Mansat Eric Delabesse Laurent Vallar François Delhommeau Isabelle Jouanin Ouathek Ouerfelli Laurent Le Cam Laetitia K Linares Christophe Junot Jean-Charles Portais François Vergez Christian Récher Jean-Emmanuel Sarry

J Exp Med 2016 Apr 7;213(4):483-97. Epub 2016 Mar 7.

Institut National de la Santé et de la Recherche Médicale (INSERM), Cancer Research Center of Toulouse, U1037, F-31024 Toulouse, France Université de Toulouse, F-31300 Toulouse, France

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April 2016

Loss of BAP1 function leads to EZH2-dependent transformation.

Authors:
Lindsay M LaFave Wendy Béguelin Richard Koche Matt Teater Barbara Spitzer Alan Chramiec Efthymia Papalexi Matthew D Keller Todd Hricik Katerina Konstantinoff Jean-Baptiste Micol Benjamin Durham Sarah K Knutson John E Campbell Gil Blum Xinxu Shi Emma H Doud Andrei V Krivtsov Young Rock Chung Inna Khodos Elisa de Stanchina Ouathek Ouerfelli Prasad S Adusumilli Paul M Thomas Neil L Kelleher Minkui Luo Heike Keilhack Omar Abdel-Wahab Ari Melnick Scott A Armstrong Ross L Levine

Nat Med 2015 Nov 5;21(11):1344-9. Epub 2015 Oct 5.

Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA.

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November 2015

Human Cancer Antigen Globo H Is a Cell-Surface Ligand for Human Ribonuclease 1.

Authors:
Chelcie H Eller Tzu-Yuan Chao Kiran K Singarapu Ouathek Ouerfelli Guangbin Yang John L Markley Samuel J Danishefsky Ronald T Raines

ACS Cent Sci 2015 Jul 13;1(4):181-190. Epub 2015 Jul 13.

Department of Biochemistry, National Magnetic Resonance Facility at Madison, and Department of Chemistry, University of Wisconsin-Madison , Madison, Wisconsin 53706, United States ; Department of Biochemistry, National Magnetic Resonance Facility at Madison, and Department of Chemistry, University of Wisconsin-Madison , Madison, Wisconsin 53706, United States.

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July 2015

Stressed mycobacteria use the chaperone ClpB to sequester irreversibly oxidized proteins asymmetrically within and between cells.

Authors:
Julien Vaubourgeix Gang Lin Neeraj Dhar Nicolas Chenouard Xiuju Jiang Helene Botella Tania Lupoli Olivia Mariani Guangli Yang Ouathek Ouerfelli Michael Unser Dirk Schnappinger John McKinney Carl Nathan

Cell Host Microbe 2015 Feb 22;17(2):178-90. Epub 2015 Jan 22.

Department of Microbiology and Immunology, Weill Cornell Medical College, New York, NY 10065, USA. Electronic address:

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February 2015

DNA repair. Mechanism of DNA interstrand cross-link processing by repair nuclease FAN1.

Authors:
Renjing Wang Nicole S Persky Barney Yoo Ouathek Ouerfelli Agata Smogorzewska Stephen J Elledge Nikola P Pavletich

Science 2014 Nov;346(6213):1127-30

Structural Biology Program and Howard Hughes Medical Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

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November 2014

Affinity of monoclonal antibodies for Globo-series glycans.

Authors:
Chelcie H Eller Guangbin Yang Ouathek Ouerfelli Ronald T Raines

Carbohydr Res 2014 Oct 14;397:1-6. Epub 2014 Jul 14.

Department of Biochemistry, University of Wisconsin-Madison, 433 Babcock Drive, Madison, WI 53706-1544, USA; Department Chemistry, University of Wisconsin-Madison, Madison, WI 53706, USA. Electronic address:

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October 2014

Evaluation of glycodendron and synthetically modified dextran clearing agents for multistep targeting of radioisotopes for molecular imaging and radioimmunotherapy.

Authors:
Sarah M Cheal Barney Yoo Sarah Boughdad Blesida Punzalan Guangbin Yang Anna Dilhas Geralda Torchon Jun Pu Don B Axworthy Pat Zanzonico Ouathek Ouerfelli Steven M Larson

Mol Pharm 2014 Feb 23;11(2):400-16. Epub 2013 Nov 23.

Department of Radiology, ‡Organic Synthesis Core Facility, §Program in Molecular Pharmacology and Chemistry, and ∥Molecular Pharmacology and Therapy Service, Memorial Sloan-Kettering Cancer Center , New York, New York 10065, United States.

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February 2014

N-acetylgalactosamino dendrons as clearing agents to enhance liver targeting of model antibody-fusion protein.

Authors:
Barney Yoo Sarah M Cheal Geralda Torchon Anna Dilhas Guangbin Yang Jun Pu Blesida Punzalan Steven M Larson Ouathek Ouerfelli

Bioconjug Chem 2013 Dec 18;24(12):2088-103. Epub 2013 Nov 18.

Organic Synthesis Core Facility, ‡Molecular Pharmacology and Chemistry Program, §Department of Radiology, and ∥Molecular Pharmacology and Therapy Service, Memorial Sloan-Kettering Cancer Center , New York, New York, United States.

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December 2013

Inhibitors of Hedgehog acyltransferase block Sonic Hedgehog signaling.

Authors:
Elissaveta Petrova Jessica Rios-Esteves Ouathek Ouerfelli J Fraser Glickman Marilyn D Resh

Nat Chem Biol 2013 Apr 17;9(4):247-9. Epub 2013 Feb 17.

Cell Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.

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April 2013

Nonsteroidal anti-inflammatory drug sensitizes Mycobacterium tuberculosis to endogenous and exogenous antimicrobials.

Authors:
Ben Gold Maneesh Pingle Steven J Brickner Nilesh Shah Julia Roberts Mark Rundell W Clay Bracken Thulasi Warrier Selin Somersan Aditya Venugopal Crystal Darby Xiuju Jiang J David Warren Joseph Fernandez Ouathek Ouerfelli Eric L Nuermberger Amy Cunningham-Bussel Poonam Rath Tamutenda Chidawanyika Haiteng Deng Ronald Realubit J Fraser Glickman Carl F Nathan

Proc Natl Acad Sci U S A 2012 Oct 10;109(40):16004-11. Epub 2012 Sep 10.

Department of Microbiology, Weill Cornell Medical College, New York, NY 10065, USA.

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October 2012

ARN-509: a novel antiandrogen for prostate cancer treatment.

Authors:
Nicola J Clegg John Wongvipat James D Joseph Chris Tran Samedy Ouk Anna Dilhas Yu Chen Kate Grillot Eric D Bischoff Ling Cai Anna Aparicio Steven Dorow Vivek Arora Gang Shao Jing Qian Hong Zhao Guangbin Yang Chunyan Cao John Sensintaffar Teresa Wasielewska Mark R Herbert Celine Bonnefous Beatrice Darimont Howard I Scher Peter Smith-Jones Mark Klang Nicholas D Smith Elisa De Stanchina Nian Wu Ouathek Ouerfelli Peter J Rix Richard A Heyman Michael E Jung Charles L Sawyers Jeffrey H Hager

Cancer Res 2012 Mar 20;72(6):1494-503. Epub 2012 Jan 20.

Human Oncology & Pathogenesis Program, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.

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March 2012

Superoxide dismutase 1 (SOD1) is a target for a small molecule identified in a screen for inhibitors of the growth of lung adenocarcinoma cell lines.

Authors:
Romel Somwar Hediye Erdjument-Bromage Erik Larsson David Shum William W Lockwood Guangli Yang Chris Sander Ouathek Ouerfelli Paul J Tempst Hakim Djaballah Harold E Varmus

Proc Natl Acad Sci U S A 2011 Sep 19;108(39):16375-80. Epub 2011 Sep 19.

High Throughput Screening Core Facility, and Organic Synthesis Core Facility, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA. or

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September 2011

Emergence of potent inhibitors of metastasis in lung cancer via syntheses based on migrastatin.

Authors:
Nicolas Lecomte Jon T Njardarson Pavel Nagorny Guangli Yang Robert Downey Ouathek Ouerfelli Malcolm A S Moore Samuel J Danishefsky

Proc Natl Acad Sci U S A 2011 Sep 1;108(37):15074-8. Epub 2011 Aug 1.

Department of Surgery, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.

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September 2011

Radiosynthesis of the tumor hypoxia marker [18F]TFMISO via O-[18F]trifluoroethylation reveals a striking difference between trifluoroethyl tosylate and iodide in regiochemical reactivity toward oxygen nucleophiles.

Authors:
Makiko Suehiro Guangbin Yang Geralda Torchon Ellen Ackerstaff John Humm Jason Koutcher Ouathek Ouerfelli

Bioorg Med Chem 2011 Apr 18;19(7):2287-97. Epub 2011 Feb 18.

Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

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April 2011

A protecting group-free synthesis of deazathiamine: a step toward inhibitor design.

Authors:
Hong Zhao Luiz Pedro S de Carvalho Carl Nathan Ouathek Ouerfelli

Bioorg Med Chem Lett 2010 Nov 16;20(22):6472-4. Epub 2010 Sep 16.

Organic Synthesis Core Facility, Molecular Pharmacology and Chemistry Program, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, PO Box 237, New York, NY 10065, United States.

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November 2010

HSP90 is a therapeutic target in JAK2-dependent myeloproliferative neoplasms in mice and humans.

Authors:
Sachie Marubayashi Priya Koppikar Tony Taldone Omar Abdel-Wahab Nathan West Neha Bhagwat Eloisi Caldas-Lopes Kenneth N Ross Mithat Gönen Alex Gozman James H Ahn Anna Rodina Ouathek Ouerfelli Guangbin Yang Cyrus Hedvat James E Bradner Gabriela Chiosis Ross L Levine

J Clin Invest 2010 Oct 13;120(10):3578-93. Epub 2010 Sep 13.

Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA.

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October 2010

Inhibition of human peptide deformylase disrupts mitochondrial function.

Authors:
Sindy Escobar-Alvarez Jeffrey Gardner Aneesh Sheth Giovanni Manfredi Guangli Yang Ouathek Ouerfelli Mark L Heaney David A Scheinberg

Mol Cell Biol 2010 Nov 30;30(21):5099-109. Epub 2010 Aug 30.

Molecular Pharmacology and Chemistry, Sloan-Kettering Institute, New York, NY 10065, USA.

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November 2010

Confirmation of the Structures of Synthetic Derivatives of Migrastatin in the Light of Recently Disclosed Crystallographically Based Claims.

Authors:
Pavel Nagorny Isaac Krauss Jón T Njardarson Lucy Perez Christoph Gaul Guangli Yang Ouathek Ouerfelli Samuel J Danishefsky

Tetrahedron Lett 2010 Jul;51(30):3873-3875

Laboratory for Bioorganic Chemistry, Sloan-Kettering Institute for Cancer Research, Laboratory for Bioorganic Chemistry.

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July 2010

Activity-based metabolomic profiling of enzymatic function: identification of Rv1248c as a mycobacterial 2-hydroxy-3-oxoadipate synthase.

Authors:
Luiz Pedro S de Carvalho Hong Zhao Caitlyn E Dickinson Nancy M Arango Christopher D Lima Steven M Fischer Ouathek Ouerfelli Carl Nathan Kyu Y Rhee

Chem Biol 2010 Apr;17(4):323-32

Department of Microbiology and Immunology, Weill Cornell Medical College, 1300 York Avenue, New York, NY 10065, USA.

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April 2010

Diverted total synthesis leads to the generation of promising cell-migration inhibitors for treatment of tumor metastasis: in vivo and mechanistic studies on the migrastatin core ether analog.

Authors:
Thordur Oskarsson Pavel Nagorny Isaac J Krauss Lucy Perez Mihirbaran Mandal Guangli Yang Ouathek Ouerfelli Danhua Xiao Malcolm A S Moore Joan Massagué Samuel J Danishefsky

J Am Chem Soc 2010 Mar;132(9):3224-8

Cancer Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10065, USA.

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March 2010

Dual targeting of EGFR can overcome a major drug resistance mutation in mouse models of EGFR mutant lung cancer.

Authors:
Lucia Regales Yixuan Gong Ronglai Shen Elisa de Stanchina Igor Vivanco Aviva Goel Jason A Koutcher Maria Spassova Ouathek Ouerfelli Ingo K Mellinghoff Maureen F Zakowski Katerina A Politi William Pao

J Clin Invest 2009 Oct 14;119(10):3000-10. Epub 2009 Sep 14.

Pao Laboratory, Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.

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October 2009

Radiosynthesis of [(131)I]IAZGP via nucleophilic substitution and its biological evaluation as a hypoxia marker - is specific activity a factor influencing hypoxia-mapping ability of a hypoxia marker?

Authors:
Makiko Suehiro Paul Burgman Sean Carlin Sean Burke Guangbin Yang Ouathek Ouerfelli Christoph Oehler-Janne Joseph O'Donoghue Clifton Ling John Humm

Nucl Med Biol 2009 Jul 7;36(5):477-87. Epub 2009 May 7.

Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

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July 2009

From synthesis to biologics: preclinical data on a chemistry derived anticancer vaccine.

Authors:
Jianglong Zhu Qian Wan Dongjoo Lee Guangbin Yang Maria K Spassova Ouathek Ouerfelli Govind Ragupathi Payal Damani Philip O Livingston Samuel J Danishefsky

J Am Chem Soc 2009 Jul;131(26):9298-303

Laboratory for Bioorganic Chemistry, Clinical Immunology Service, Department of Medicine, Sloan-Kettering Institute for Cancer Research, 1275 York Avenue, New York, New York 10065, USA.

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July 2009

Early hematopoietic zinc finger protein prevents tumor cell recognition by natural killer cells.

Authors:
Rosanna La Rocca Mariateresa Fulciniti Tadepally Lakshmikanth Maria Mesuraca Talib Hassan Ali Valerio Mazzei Nicola Amodio Lucio Catalano Bruno Rotoli Ouathek Ouerfelli Michele Grieco Elio Gulletta Heather M Bond Giovanni Morrone Soldano Ferrone Ennio Carbone

J Immunol 2009 Apr;182(8):4529-37

Department of Experimental and Clinical Medicine G Salvatore, University of Catanzaro Magna Graecia, Catanzaro, Italy.

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April 2009

Synthesis of Human Cancer Associated Globo-H (MBr1) Glycosylamino Acid: Some Mechanistic and Conformational Reinvestigations.

Authors:
Jianglong Zhu Qian Wan Guangbin Yang Ouathek Ouerfelli Samuel J Danishefsky

Heterocycles 2009 Apr;79(1):441-449

Laboratory for Bioorganic Chemistry, Sloan-Kettering Institute for Cancer Research, 1275 York Ave., New York, NY 10065.

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April 2009

Structure and activity of human mitochondrial peptide deformylase, a novel cancer target.

Authors:
Sindy Escobar-Alvarez Yehuda Goldgur Guangli Yang Ouathek Ouerfelli Yueming Li David A Scheinberg

J Mol Biol 2009 Apr 21;387(5):1211-28. Epub 2009 Feb 21.

Molecular Pharmacology and Chemistry Program, Sloan-Kettering Institute, 415 E. 68th Street Zuckerman Z1941, New York, NY 10065, USA.

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April 2009

Characterization of the catalytic activity of the membrane-anchored metalloproteinase ADAM15 in cell-based assays.

Authors:
Thorsten Maretzky Guangli Yang Ouathek Ouerfelli Christopher M Overall Susanne Worpenberg Ulrich Hassiepen Joerg Eder Carl P Blobel

Biochem J 2009 Apr 28;420(1):105-13. Epub 2009 Apr 28.

Arthritis and Tissue Degeneration Program, Hospital for Special Surgery at Weill Medical College of Cornell University, 535 E 70th Street, New York, NY 10021, USA.

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April 2009

Stereo-controlled synthesis of novel photoreactive gamma-secretase inhibitors.

Authors:
Guangli Yang Ye Ingrid Yin Jiong Chun Christopher C Shelton Ouathek Ouerfelli Yue-Ming Li

Bioorg Med Chem Lett 2009 Feb 7;19(3):922-5. Epub 2008 Dec 7.

Organic Synthesis Core Facility, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.

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February 2009

Pilot study of a heptavalent vaccine-keyhole limpet hemocyanin conjugate plus QS21 in patients with epithelial ovarian, fallopian tube, or peritoneal cancer.

Authors:
Paul J Sabbatini Govind Ragupathi Chandra Hood Carol A Aghajanian Margrit Juretzka Alexia Iasonos Martee L Hensley Maria K Spassova Ouathek Ouerfelli David R Spriggs William P Tew Jason Konner Henrik Clausen Nadeem Abu Rustum Samuel J Dansihefsky Philip O Livingston

Clin Cancer Res 2007 Jul;13(14):4170-7

Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.

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July 2007

High-throughput identification of inhibitors of human mitochondrial peptide deformylase.

Authors:
Christophe Antczak David Shum Sindy Escobar Bhramdeo Bassit Earl Kim Venkatraman E Seshan Nian Wu Guangli Yang Ouathek Ouerfelli Yue-Ming Li David A Scheinberg Hakim Djaballah

J Biomol Screen 2007 Jun 13;12(4):521-35. Epub 2007 Apr 13.

High Throughput Screening Core Facility, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.

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June 2007

Novel D761Y and common secondary T790M mutations in epidermal growth factor receptor-mutant lung adenocarcinomas with acquired resistance to kinase inhibitors.

Authors:
Marissa N Balak Yixuan Gong Gregory J Riely Romel Somwar Allan R Li Maureen F Zakowski Anne Chiang Guangli Yang Ouathek Ouerfelli Mark G Kris Marc Ladanyi Vincent A Miller William Pao

Clin Cancer Res 2006 Nov;12(21):6494-501

Human Oncology and Pathogenesis Program, Thoracic Oncology Service, Varmus Lab, Department of Pathology, Memorial Sloan-Kettering Cancer Center, Weill Medical College of Cornell University, New York, New York 10021, USA.

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November 2006

A peptidomimetic siRNA transfection reagent for highly effective gene silencing.

Authors:
Yeliz Utku Elinor Dehan Ouathek Ouerfelli Fabio Piano Ronald N Zuckermann Michele Pagano Kent Kirshenbaum

Mol Biosyst 2006 Jun 17;2(6-7):312-7. Epub 2006 May 17.

Department of Chemistry, New York University, New York, NY 10003, USA.

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June 2006

Preparation and evaluation of unimolecular pentavalent and hexavalent antigenic constructs targeting prostate and breast cancer: a synthetic route to anticancer vaccine candidates.

Authors:
Govind Ragupathi Fusataka Koide Philip O Livingston Young Shin Cho Atsushi Endo Qian Wan Maria K Spassova Stacy J Keding Jennifer Allen Ouathek Ouerfelli Rebecca M Wilson Samuel J Danishefsky

J Am Chem Soc 2006 Mar;128(8):2715-25

Laboratory of Tumor Vaccinology, Clinical Immunology Service, Department of Medicine, the Laboratory for Bioorganic Chemistry, Sloan-Kettering Institute for Cancer Research, New York, New York 10021, USA.

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March 2006

Synthetic carbohydrate-based antitumor vaccines: challenges and opportunities.

Authors:
Ouathek Ouerfelli J David Warren Rebecca M Wilson Samuel J Danishefsky

Expert Rev Vaccines 2005 Oct;4(5):677-85

Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.

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October 2005

Sequence characteristics of functional siRNAs.

Authors:
Bernd Jagla Nathalie Aulner Peter D Kelly Da Song Allen Volchuk Andrzej Zatorski David Shum Thomas Mayer Dino A De Angelis Ouathek Ouerfelli Urs Rutishauser James E Rothman

RNA 2005 Jun;11(6):864-72

Functional Proteomics Project, Memorial Sloan-Kettering Cance Center, New York, NY, USA.

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June 2005

Chemical inhibition of N-WASP by stabilization of a native autoinhibited conformation.

Authors:
Jeffrey R Peterson Lincoln C Bickford David Morgan Annette S Kim Ouathek Ouerfelli Marc W Kirschner Michael K Rosen

Nat Struct Mol Biol 2004 Aug 4;11(8):747-55. Epub 2004 Jul 4.

Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, Massachusetts 02115, USA.

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August 2004