Publications by authors named "Ouathek Ouerfelli"

53Publications

Synthesis of the PET Tracer I-Trametinib for MAPK/ERK Kinase Distribution and Resistance Monitoring.

J Nucl Med 2020 Dec 22;61(12):1845-1850. Epub 2020 May 22.

Department of Pharmacology, Weill Cornell Graduate School, New York, New York

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December 2020

An -Acetylgalactosamino Dendron-Clearing Agent for High-Therapeutic-Index DOTA-Hapten Pretargeted Radioimmunotherapy.

Bioconjug Chem 2020 03 10;31(3):501-506. Epub 2020 Feb 10.

Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, United States.

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March 2020

The Polycomb Repressor Complex 1 Drives Double-Negative Prostate Cancer Metastasis by Coordinating Stemness and Immune Suppression.

Cancer Cell 2019 08 18;36(2):139-155.e10. Epub 2019 Jul 18.

Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Unit 1906, PO Box 301429, Houston, TX 77054/77030-1429, USA; Department of Genitourinary Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA. Electronic address:

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August 2019

CRISPR-Cas III-A Csm6 CARF Domain Is a Ring Nuclease Triggering Stepwise cA Cleavage with ApA>p Formation Terminating RNase Activity.

Mol Cell 2019 09 17;75(5):944-956.e6. Epub 2019 Jul 17.

Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Electronic address:

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September 2019

BET Inhibition-Induced GSK3β Feedback Enhances Lymphoma Vulnerability to PI3K Inhibitors.

Cell Rep 2018 08;24(8):2155-2166

Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Lymphoma Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA. Electronic address:

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August 2018

Targetable Clinical Nanoparticles for Precision Cancer Therapy Based on Disease-Specific Molecular Inflection Points.

Nano Lett 2017 11 23;17(11):7160-7168. Epub 2017 Oct 23.

Departments of Pharmacology and Radiology, Weill Cornell Medical College , New York, New York 10065, United States.

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November 2017

Distinct Spatiotemporal Dynamics of Peptidoglycan Synthesis between and .

mBio 2017 09 12;8(5). Epub 2017 Sep 12.

Department of Microbiology and Immunology, Weill Cornell Medical College, New York, New York, USA

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September 2017

Increased Airport Scrutiny by the Transportation Security Administration of a Patient-Passenger Carrying Ammonium Lactate-Containing Moisturizer.

JAMA Dermatol 2016 09;152(9):1054-5

Dermatology Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York.

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September 2016

Human Cancer Antigen Globo H Is a Cell-Surface Ligand for Human Ribonuclease 1.

ACS Cent Sci 2015 Jul 13;1(4):181-190. Epub 2015 Jul 13.

Department of Biochemistry, National Magnetic Resonance Facility at Madison, and Department of Chemistry, University of Wisconsin-Madison , Madison, Wisconsin 53706, United States ; Department of Biochemistry, National Magnetic Resonance Facility at Madison, and Department of Chemistry, University of Wisconsin-Madison , Madison, Wisconsin 53706, United States.

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July 2015

DNA repair. Mechanism of DNA interstrand cross-link processing by repair nuclease FAN1.

Science 2014 Nov;346(6213):1127-30

Structural Biology Program and Howard Hughes Medical Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

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November 2014

Affinity of monoclonal antibodies for Globo-series glycans.

Carbohydr Res 2014 Oct 14;397:1-6. Epub 2014 Jul 14.

Department of Biochemistry, University of Wisconsin-Madison, 433 Babcock Drive, Madison, WI 53706-1544, USA; Department Chemistry, University of Wisconsin-Madison, Madison, WI 53706, USA. Electronic address:

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October 2014

Evaluation of glycodendron and synthetically modified dextran clearing agents for multistep targeting of radioisotopes for molecular imaging and radioimmunotherapy.

Mol Pharm 2014 Feb 23;11(2):400-16. Epub 2013 Nov 23.

Department of Radiology, ‡Organic Synthesis Core Facility, §Program in Molecular Pharmacology and Chemistry, and ∥Molecular Pharmacology and Therapy Service, Memorial Sloan-Kettering Cancer Center , New York, New York 10065, United States.

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February 2014

N-acetylgalactosamino dendrons as clearing agents to enhance liver targeting of model antibody-fusion protein.

Bioconjug Chem 2013 Dec 18;24(12):2088-103. Epub 2013 Nov 18.

Organic Synthesis Core Facility, ‡Molecular Pharmacology and Chemistry Program, §Department of Radiology, and ∥Molecular Pharmacology and Therapy Service, Memorial Sloan-Kettering Cancer Center , New York, New York, United States.

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December 2013

Inhibitors of Hedgehog acyltransferase block Sonic Hedgehog signaling.

Nat Chem Biol 2013 Apr 17;9(4):247-9. Epub 2013 Feb 17.

Cell Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.

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April 2013

Superoxide dismutase 1 (SOD1) is a target for a small molecule identified in a screen for inhibitors of the growth of lung adenocarcinoma cell lines.

Proc Natl Acad Sci U S A 2011 Sep 19;108(39):16375-80. Epub 2011 Sep 19.

High Throughput Screening Core Facility, and Organic Synthesis Core Facility, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA. or

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September 2011

Emergence of potent inhibitors of metastasis in lung cancer via syntheses based on migrastatin.

Proc Natl Acad Sci U S A 2011 Sep 1;108(37):15074-8. Epub 2011 Aug 1.

Department of Surgery, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.

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September 2011

A protecting group-free synthesis of deazathiamine: a step toward inhibitor design.

Bioorg Med Chem Lett 2010 Nov 16;20(22):6472-4. Epub 2010 Sep 16.

Organic Synthesis Core Facility, Molecular Pharmacology and Chemistry Program, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, PO Box 237, New York, NY 10065, United States.

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November 2010

Inhibition of human peptide deformylase disrupts mitochondrial function.

Mol Cell Biol 2010 Nov 30;30(21):5099-109. Epub 2010 Aug 30.

Molecular Pharmacology and Chemistry, Sloan-Kettering Institute, New York, NY 10065, USA.

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November 2010

From synthesis to biologics: preclinical data on a chemistry derived anticancer vaccine.

J Am Chem Soc 2009 Jul;131(26):9298-303

Laboratory for Bioorganic Chemistry, Clinical Immunology Service, Department of Medicine, Sloan-Kettering Institute for Cancer Research, 1275 York Avenue, New York, New York 10065, USA.

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July 2009

Synthesis of Human Cancer Associated Globo-H (MBr1) Glycosylamino Acid: Some Mechanistic and Conformational Reinvestigations.

Heterocycles 2009 Apr;79(1):441-449

Laboratory for Bioorganic Chemistry, Sloan-Kettering Institute for Cancer Research, 1275 York Ave., New York, NY 10065.

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April 2009

Structure and activity of human mitochondrial peptide deformylase, a novel cancer target.

J Mol Biol 2009 Apr 21;387(5):1211-28. Epub 2009 Feb 21.

Molecular Pharmacology and Chemistry Program, Sloan-Kettering Institute, 415 E. 68th Street Zuckerman Z1941, New York, NY 10065, USA.

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April 2009

Characterization of the catalytic activity of the membrane-anchored metalloproteinase ADAM15 in cell-based assays.

Biochem J 2009 Apr 28;420(1):105-13. Epub 2009 Apr 28.

Arthritis and Tissue Degeneration Program, Hospital for Special Surgery at Weill Medical College of Cornell University, 535 E 70th Street, New York, NY 10021, USA.

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April 2009

Stereo-controlled synthesis of novel photoreactive gamma-secretase inhibitors.

Bioorg Med Chem Lett 2009 Feb 7;19(3):922-5. Epub 2008 Dec 7.

Organic Synthesis Core Facility, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.

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February 2009

High-throughput identification of inhibitors of human mitochondrial peptide deformylase.

J Biomol Screen 2007 Jun 13;12(4):521-35. Epub 2007 Apr 13.

High Throughput Screening Core Facility, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.

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June 2007

Novel D761Y and common secondary T790M mutations in epidermal growth factor receptor-mutant lung adenocarcinomas with acquired resistance to kinase inhibitors.

Clin Cancer Res 2006 Nov;12(21):6494-501

Human Oncology and Pathogenesis Program, Thoracic Oncology Service, Varmus Lab, Department of Pathology, Memorial Sloan-Kettering Cancer Center, Weill Medical College of Cornell University, New York, New York 10021, USA.

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November 2006

A peptidomimetic siRNA transfection reagent for highly effective gene silencing.

Mol Biosyst 2006 Jun 17;2(6-7):312-7. Epub 2006 May 17.

Department of Chemistry, New York University, New York, NY 10003, USA.

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June 2006

Preparation and evaluation of unimolecular pentavalent and hexavalent antigenic constructs targeting prostate and breast cancer: a synthetic route to anticancer vaccine candidates.

J Am Chem Soc 2006 Mar;128(8):2715-25

Laboratory of Tumor Vaccinology, Clinical Immunology Service, Department of Medicine, the Laboratory for Bioorganic Chemistry, Sloan-Kettering Institute for Cancer Research, New York, New York 10021, USA.

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March 2006

Synthetic carbohydrate-based antitumor vaccines: challenges and opportunities.

Expert Rev Vaccines 2005 Oct;4(5):677-85

Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.

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October 2005

Chemical inhibition of N-WASP by stabilization of a native autoinhibited conformation.

Nat Struct Mol Biol 2004 Aug 4;11(8):747-55. Epub 2004 Jul 4.

Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, Massachusetts 02115, USA.

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August 2004