Otmar D Wiestler

Otmar D Wiestler

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Otmar D Wiestler

Otmar D Wiestler

Publications by authors named "Otmar D Wiestler"

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The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary.

Acta Neuropathol 2016 06 9;131(6):803-20. Epub 2016 May 9.

Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN, USA.

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http://dx.doi.org/10.1007/s00401-016-1545-1DOI Listing
June 2016

Assessing CpG island methylator phenotype, 1p/19q codeletion, and MGMT promoter methylation from epigenome-wide data in the biomarker cohort of the NOA-04 trial.

Neuro Oncol 2014 Dec 15;16(12):1630-8. Epub 2014 Jul 15.

Department of Neurooncology (B.W., M.P., W.W.); Department of Neuropathology (D.C., A.v.D.); Department of Pediatric Oncology, Hematology, and Immunology, Heidelberg University Hospital (S.M.P.); Clinical Cooperation Units Neurooncology (B.W., W.W.), Neuropathology (D.C, A.v.D.); Neuroimmunology and Brain Tumor Immunology (M.P.); Division of Molecular Genetics (V.H.); Division of Biostatistics (M.S.); Division of Pediatric Neurooncology (S.M.P., D.T.W.J.), German Cancer Research Center (DKFZ), Heidelberg, Germany (O.D.W.) and German Cancer Consortium (DKTK); Department for Neuropathology, Institute of Pathology, Medical University of Hannover, Hannover, Germany (C.H.); Department of Neuropathology, Heinrich-Heine-University, Düsseldorf, Germany (J.F., G.R.); German Consortium for Translational Cancer Research (DKTK), Düsseldorf, Germany (M.P., G.R.); Institute for Neuropathology, Saarland University, 66421 Saarbrücken, Germany (W.F.); Institute for Neuropathology, University of Essen Medical School, Essen, Germany (K.K.); Institute for Neuropathology, University of Tübingen, Tübingen, Germany (R.M.); Department of Neuropathology, University of Bonn Medical Center, Bonn, Germany (T.P.); Department of Neurology, University Hospital Zurich, Zürich, Switzerland (M.W.).

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http://dx.doi.org/10.1093/neuonc/nou138DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4232086PMC
December 2014

Danger signaling protein HMGB1 induces a distinct form of cell death accompanied by formation of giant mitochondria.

Cancer Res 2010 Nov 19;70(21):8558-68. Epub 2010 Oct 19.

German Cancer Research Center, Institute of Pathology, University of Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1158/0008-5472.CAN-10-0204DOI Listing
November 2010

Mutations of CARD11 but not TNFAIP3 may activate the NF-kappaB pathway in primary CNS lymphoma.

Acta Neuropathol 2010 Oct 11;120(4):529-35. Epub 2010 Jun 11.

Department of Neuropathology, University Hospital Cologne, 50924 Cologne, Germany.

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http://dx.doi.org/10.1007/s00401-010-0709-7DOI Listing
October 2010

Array-based DNA methylation profiling of primary lymphomas of the central nervous system.

BMC Cancer 2009 Dec 21;9:455. Epub 2009 Dec 21.

Institute of Human Genetics, University Hospital Schleswig-Holstein Campus Kiel/Christian-Albrechts University Kiel, Germany.

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http://dx.doi.org/10.1186/1471-2407-9-455DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2807878PMC
December 2009

Outcome prediction in pediatric medulloblastoma based on DNA copy-number aberrations of chromosomes 6q and 17q and the MYC and MYCN loci.

J Clin Oncol 2009 Apr 2;27(10):1627-36. Epub 2009 Mar 2.

Division of Molecular Genetics and Biostatistics and Clinical Cooperation Unit Neuropathology, German Cancer Research Center, Department of Pediatric Oncology, Hematology and Immunology, University of Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1200/JCO.2008.17.9432DOI Listing
April 2009

Mechanisms of Disease: cancer stem cells--targeting the evil twin.

Nat Clin Pract Oncol 2008 Jun 22;5(6):337-47. Epub 2008 Apr 22.

Genetics and Stem Cell Laboratory, Ecole Polytechnique Fédérale de Lausanne, Swiss Institute for Experimental Cancer Research, School of Life Science, Epalinges, Switzerland.

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http://dx.doi.org/10.1038/ncponc1110DOI Listing
June 2008

Basal caspase activity promotes migration and invasiveness in glioblastoma cells.

Mol Cancer Res 2007 Dec;5(12):1232-40

Molecular Neuro-Oncology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.1158/1541-7786.MCR-07-0343DOI Listing
December 2007

The 2007 WHO classification of tumours of the central nervous system.

Acta Neuropathol 2007 Aug 6;114(2):97-109. Epub 2007 Jul 6.

Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.

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http://dx.doi.org/10.1007/s00401-007-0243-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1929165PMC
August 2007

Molecular genetic analysis of central nervous system germ cell tumors with comparative genomic hybridization.

Mod Pathol 2006 Jun;19(6):864-73

Clinic of Paediatric Oncology, Haematology and Immunology, Heinrich-Heine-University, Düsseldorf, Germany.

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http://dx.doi.org/10.1038/modpathol.3800607DOI Listing
June 2006

[Cancer research at the transition from bench to bedside].

Med Klin (Munich) 2006 Feb;101(2):153-9

Vorsitzender und Wissenschaftlicher Vorstand, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120 Heidelberg.

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http://dx.doi.org/10.1007/s00063-006-1021-0DOI Listing
February 2006

VH gene analysis of primary CNS lymphomas.

J Neurol Sci 2005 Feb 19;228(2):143-7. Epub 2004 Dec 19.

Department of Neurology, University of Bonn, Bonn, Germany.

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http://dx.doi.org/10.1016/j.jns.2004.11.038DOI Listing
February 2005

Molecular profiling of temporal lobe epilepsy: comparison of data from human tissue samples and animal models.

Epilepsy Res 2004 Jul-Aug;60(2-3):173-8

Department of Neuropathology, University of Bonn Medical Center, Sigmund-Freud Street 25, D-53105 Bonn, Germany.

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http://dx.doi.org/10.1016/j.eplepsyres.2004.07.002DOI Listing
January 2005

Microtubule-associated protein-2 immunoreactivity: a useful tool in the differential diagnosis of low-grade neuroepithelial tumors.

Acta Neuropathol 2004 Aug 14;108(2):89-96. Epub 2004 May 14.

Department of Neuropathology, University of Erlangen-Nuremberg, 91054, Erlangen, Germany.

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http://dx.doi.org/10.1007/s00401-004-0873-8DOI Listing
August 2004

Analysis of chromosomal instability in focal cortical dysplasia of Taylor's balloon cell type.

Acta Neuropathol 2004 Aug 14;108(2):129-34. Epub 2004 May 14.

Department of Neuropathology, University of Bonn Medical Center, Sigmund-Freud Str. 25, 53105, Bonn, Germany.

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http://dx.doi.org/10.1007/s00401-004-0874-7DOI Listing
August 2004

Analysis of HIC-1 methylation and transcription in human ependymomas.

Int J Cancer 2004 Jul;110(4):542-9

Department of Neuropathology, University of Bonn, Bonn, Germany.

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http://dx.doi.org/10.1002/ijc.20165DOI Listing
July 2004

An isomorphic subtype of long-term epilepsy-associated astrocytomas associated with benign prognosis.

Acta Neuropathol 2004 May 19;107(5):381-8. Epub 2004 Mar 19.

Department of Neuropathology, University of Erlangen-Nürnberg, Krankenhausstrasse 8-10, 91054 Erlangen, Germany.

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http://link.springer.com/content/pdf/10.1007/s00401-004-0833
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http://link.springer.com/10.1007/s00401-004-0833-3
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http://dx.doi.org/10.1007/s00401-004-0833-3DOI Listing
May 2004

Absence of simian virus 40 DNA sequences in primary central nervous system lymphoma in HIV-negative patients.

Virchows Arch 2004 May 24;444(5):436-8. Epub 2004 Mar 24.

Department of Neuropathology, University of Cologne, Joseph-Stelzmann Strasse 9, 50931, Cologne, Germany.

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http://dx.doi.org/10.1007/s00428-004-1001-9DOI Listing
May 2004

Methylation Profiling Identifies Epigenetic Markers for High-grade Gliomas.

Cancer Genomics Proteomics 2004 May-Jun;1(3):209-214. Epub 2004 May 1.

Division of Human Cancer Genetics, Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, Columbus, Ohio, U.S.A.

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May 2004

Oligodendroglial tumors: refinement of candidate regions on chromosome arm 1p and correlation of 1p/19q status with survival.

Brain Pathol 2004 Apr;14(2):121-30

Department of Neuropathology, Heinrich-Heine-University, Moorenstrasse 5, D-40225 Düsseldorf, Germany.

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April 2004

Primary diffuse large B-cell lymphomas of the central nervous system are targeted by aberrant somatic hypermutation.

Blood 2004 Mar 30;103(5):1869-75. Epub 2003 Oct 30.

Department of Neuropathology, University of Cologne, Köln, Germany.

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http://dx.doi.org/10.1182/blood-2003-05-1465DOI Listing
March 2004

Epigenetic silencing of the HIC-1 gene in human medulloblastomas.

J Neuropathol Exp Neurol 2003 Nov;62(11):1192-201

Department of Neuropathology, University of Bonn, Bonn, Germany.

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http://dx.doi.org/10.1093/jnen/62.11.1192DOI Listing
November 2003

Correlated stage- and subfield-associated hippocampal gene expression patterns in experimental and human temporal lobe epilepsy.

Eur J Neurosci 2003 Nov;18(10):2792-802

Department of Neuropathology, University of Bonn Medical Center, Sigmund-Freud Strasse 25, D-53105 Bonn, Germany.

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http://dx.doi.org/10.1111/j.1460-9568.2003.02993.xDOI Listing
November 2003

Migration and differentiation of myogenic precursors following transplantation into the developing rat brain.

Stem Cells 2003 ;21(2):181-9

Institute of Reconstructive Neurobiology, University of Bonn, Germany.

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http://dx.doi.org/10.1634/stemcells.21-2-181DOI Listing
September 2003

Chromosomal region 15q21.1 is a frequent target of allelic imbalance in advanced breast carcinomas.

Int J Cancer 2003 Aug;106(1):74-7

Department of Obstetrics and Gynecology, Medical Center, University of Bonn, Bonn, Germany.

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http://dx.doi.org/10.1002/ijc.11169DOI Listing
August 2003

Neurocytoma arising in the pelvis.

Virchows Arch 2003 Aug 3;443(2):217-9. Epub 2003 Jul 3.

Institute of Pathology, University of Bonn, Sigmund-Freud-Strasse 25, 53127 Bonn, Germany.

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http://dx.doi.org/10.1007/s00428-003-0852-9DOI Listing
August 2003

Analysis of the TP53 gene in laser-microdissected glioblastoma vasculature.

Acta Neuropathol 2003 Apr 14;105(4):328-32. Epub 2003 Feb 14.

Department of Pathology and Neuropathology, Tartu University Clinics, Tartu, Estonia.

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http://dx.doi.org/10.1007/s00401-003-0681-6DOI Listing
April 2003

Genetic alterations commonly found in diffusely infiltrating cerebral gliomas are rare or absent in pleomorphic xanthoastrocytomas.

J Neuropathol Exp Neurol 2002 Dec;61(12):1092-9

Department of Neuropathology, Heinrich-Heine-University, Düsseldorf, Germany.

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http://dx.doi.org/10.1093/jnen/61.12.1092DOI Listing
December 2002

Mutational and expression analysis of the reelin pathway components CDK5 and doublecortin in gangliogliomas.

Acta Neuropathol 2002 Oct 19;104(4):403-8. Epub 2002 Jun 19.

Department of Neuropathology, University of Bonn Medical Center, Sigmund-Freud-Strasse 25, 53105 Bonn, Germany.

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http://link.springer.de/link/service/journals/00401/contents
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http://dx.doi.org/10.1007/s00401-002-0570-4DOI Listing
October 2002

Tau EGFP embryonic stem cells: an efficient tool for neuronal lineage selection and transplantation.

J Neurosci Res 2002 Sep;69(6):918-24

Institute of Reconstructive Neurobiology and Department of Neuropathology, University of Bonn Medical Center, Bonn, Germany.

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http://dx.doi.org/10.1002/jnr.10395DOI Listing
September 2002

The natural history of Rasmussen's encephalitis.

Brain 2002 Aug;125(Pt 8):1751-9

Department of Epileptology, University of Bonn, Bonn, Germany.

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http://dx.doi.org/10.1093/brain/awf176DOI Listing
August 2002

Functional genomics in experimental and human temporal lobe epilepsy: powerful new tools to identify molecular disease mechanisms of hippocampal damage.

Prog Brain Res 2002 ;135:161-73

Department of Neuropathology, University of Bonn Medical Center, Sigmund-Freud Str. 25, 53105 Bonn, Germany.

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http://linkinghub.elsevier.com/retrieve/pii/S007961230235016
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http://dx.doi.org/10.1016/S0079-6123(02)35016-7DOI Listing
August 2002

Gangliogliomas: an intriguing tumor entity associated with focal epilepsies.

J Neuropathol Exp Neurol 2002 Jul;61(7):575-84

Department of Neuropathology, University of Erlangen, Germany.

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http://dx.doi.org/10.1093/jnen/61.7.575DOI Listing
July 2002

Transcriptional profiling in human epilepsy: expression array and single cell real-time qRT-PCR analysis reveal distinct cellular gene regulation.

Neuroreport 2002 Jul;13(10):1327-33

Department of Neuropathology, University of Bonn Medical Center, Sigmund-Freud Str. 25, 53105 Bonn, Germany.

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http://dx.doi.org/10.1097/00001756-200207190-00023DOI Listing
July 2002

Prognostic impact of TP53 mutations and P53 protein overexpression in supratentorial WHO grade II astrocytomas and oligoastrocytomas.

Clin Cancer Res 2002 May;8(5):1117-24

Department of Neurosurgery, Klinikum Grosshadern, Ludwig-Maximilians-University, Munich, Germany 81377.

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May 2002

Impact of genotype and morphology on the prognosis of glioblastoma.

J Neuropathol Exp Neurol 2002 Apr;61(4):321-8

Department of Neurosurgery, University of Bonn Medical Center, Germany.

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http://dx.doi.org/10.1093/jnen/61.4.321DOI Listing
April 2002

Ammon's horn sclerosis: a maldevelopmental disorder associated with temporal lobe epilepsy.

Brain Pathol 2002 Apr;12(2):199-211

Department of Neuropathology, University of Bonn Medical Center, Germany.

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April 2002

Chromosomal imbalances in choroid plexus tumors.

Am J Pathol 2002 Mar;160(3):1105-13

Institute of Neuropathology, University Hospital Münster, Münster, Germany.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1867193PMC
http://dx.doi.org/10.1016/S0002-9440(10)64931-0DOI Listing
March 2002