Publications by authors named "Otilia Obreja"

26Publications

Slow depolarizing stimuli differentially activate mechanosensitive and silent C-nociceptors in human and pig skin.

Pain 2020 May 4. Epub 2020 May 4.

Department of Experimental Pain Research, Medical Faculty Mannheim, University of Heidelberg, Germany.

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http://dx.doi.org/10.1097/j.pain.0000000000001912DOI Listing
May 2020

TTX-Resistant Sodium Channels Functionally Separate Silent From Polymodal C-nociceptors.

Front Cell Neurosci 2020 7;14:13. Epub 2020 Feb 7.

Department of Experimental Pain Research, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.

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http://dx.doi.org/10.3389/fncel.2020.00013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7018684PMC
February 2020

Nerve growth factor locally sensitizes nociceptors in human skin.

Pain 2018 03;159(3):416-426

Department of Anesthesiology and Operative Intensive Care, Medical Faculty Mannheim, University of Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1097/j.pain.0000000000001108DOI Listing
March 2018

Cryptococcal Meningoencephalitis in a Patient With Multiple Sclerosis Treated With Fingolimod.

JAMA Neurol 2015 Oct;72(10):1203-5

Department of Neurology, Cantonal Hospital of Aarau, Aarau, Switzerland.

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http://dx.doi.org/10.1001/jamaneurol.2015.1746DOI Listing
October 2015

C-fiber recovery cycle supernormality depends on ion concentration and ion channel permeability.

Biophys J 2015 Mar;108(5):1057-71

Department of Computational Biology, School of Computer Science and Communication, KTH Royal Institute of Technology, Stockholm, Sweden; Stockholm Brain Institute, KTH Royal Institute of Technology, Stockholm, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.bpj.2014.12.034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4816283PMC
March 2015

Comparison of nerve growth factor-induced sensitization pattern in lumbar and tibial muscle and fascia.

Muscle Nerve 2015 Aug 7;52(2):265-72. Epub 2015 Jun 7.

Department of Anesthesiology and Intensive Care Medicine Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany.

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http://dx.doi.org/10.1002/mus.24537DOI Listing
August 2015

Differential axonal conduction patterns of mechano-sensitive and mechano-insensitive nociceptors--a combined experimental and modelling study.

PLoS One 2014 19;9(8):e103556. Epub 2014 Aug 19.

School of Computer Science and Communication, KTH Royal Institute of Technology, Stockholm, Sweden; Stockholm Brain Institute, KTH Royal Institute of Technology, Stockholm, Sweden.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0103556PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4138079PMC
October 2015

Modeling activity-dependent changes of axonal spike conduction in primary afferent C-nociceptors.

J Neurophysiol 2014 May 26;111(9):1721-35. Epub 2013 Dec 26.

Department of Computational Biology, School of Computer Science and Communication, KTH Royal Institute of Technology, Stockholm, Sweden;

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http://dx.doi.org/10.1152/jn.00777.2012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4044369PMC
May 2014

Inflammation meets sensitization--an explanation for spontaneous nociceptor activity?

Pain 2013 Dec 8;154(12):2707-14. Epub 2013 Aug 8.

Department of Anaesthesiology, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.pain.2013.07.054DOI Listing
December 2013

Differential effects of low dose lidocaine on C-fiber classes in humans.

J Pain 2012 Dec;13(12):1232-41

Department of Physiology and Experimental Pathophysiology, University of Erlangen/Nürnberg, Erlangen, Germany.

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http://dx.doi.org/10.1016/j.jpain.2012.09.008DOI Listing
December 2012

NGF-evoked sensitization of muscle fascia nociceptors in humans.

Pain 2012 Aug 15;153(8):1673-9. Epub 2012 Jun 15.

Department of Anaesthesiology and Intensive Care Medicine Mannheim, Heidelberg University, Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.pain.2012.04.033DOI Listing
August 2012

The differential effects of two sodium channel modulators on the conductive properties of C-fibers in pig skin in vivo.

Anesth Analg 2012 Sep 10;115(3):560-71. Epub 2012 May 10.

Department of Anesthesiology and Operative Intensive Care, Heidelberg University, Mannheim, Germany.

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http://dx.doi.org/10.1213/ANE.0b013e3182542843DOI Listing
September 2012

Double spikes to single electrical stimulation correlates to spontaneous activity of nociceptors in painful neuropathy patients.

Pain 2012 Feb 7;153(2):391-8. Epub 2011 Dec 7.

Department of Clinical Neurophysiology, University Hospital, Uppsala, Sweden.

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http://dx.doi.org/10.1016/j.pain.2011.10.041DOI Listing
February 2012

Nerve growth factor selectively decreases activity-dependent conduction slowing in mechano-insensitive C-nociceptors.

Pain 2011 Sep 18;152(9):2138-46. Epub 2011 Jul 18.

Department of Anesthesiology Mannheim, Heidelberg University, Mannheim, Germany.

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http://dx.doi.org/10.1016/j.pain.2011.05.021DOI Listing
September 2011

NGF enhances electrically induced pain, but not axon reflex sweating.

Pain 2011 Aug 4;152(8):1856-63. Epub 2011 May 4.

Department of Anaesthesiology and Intensive Care Medicine, Medical Faculty Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, Mannheim 68167, Germany.

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http://dx.doi.org/10.1016/j.pain.2011.04.002DOI Listing
August 2011

Nerve growth factor-evoked nociceptor sensitization in pig skin in vivo.

J Neurosci Res 2010 Jul;88(9):2066-72

University Clinics of Anaesthesiology and Intensive Care Medicine, University Medicine Mannheim, University of Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany.

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http://dx.doi.org/10.1002/jnr.22351DOI Listing
July 2010

NGF induces non-inflammatory localized and lasting mechanical and thermal hypersensitivity in human skin.

Pain 2010 Mar 22;148(3):407-13. Epub 2009 Dec 22.

Department of Anaesthesiology and Intensive Care Medicine Mannheim, Heidelberg University, Germany.

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http://dx.doi.org/10.1016/j.pain.2009.11.022DOI Listing
March 2010

Single-fiber recordings of unmyelinated afferents in pig.

Neurosci Lett 2010 Feb 8;470(3):175-9. Epub 2009 Oct 8.

Dept. Anesthesiology and Intensive Care Medicine, Medical Faculty Mannheim, University of Heidelberg, Theodor-Kutzer Ufer 1-3, 68137 Mannheim, Germany.

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http://dx.doi.org/10.1016/j.neulet.2009.10.006DOI Listing
February 2010

A subpopulation of capsaicin-sensitive porcine dorsal root ganglion neurons is lacking hyperpolarization-activated cyclic nucleotide-gated channels.

Eur J Pain 2008 Aug 22;12(6):775-89. Epub 2008 Jan 22.

Department of Anesthesiology and Intensive Care Medicine, Faculty of Clinical Medicine, University of Heidelberg, Mannheim, Germany.

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http://dx.doi.org/10.1016/j.ejpain.2007.11.010DOI Listing
August 2008

Potentiation of nociceptive responses to low pH injections in humans by prostaglandin E2.

J Pain 2007 May 6;8(5):443-51. Epub 2007 Mar 6.

Department of Anesthesiology and Intensive Care Medicine, Clinical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.

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http://dx.doi.org/10.1016/j.jpain.2006.12.004DOI Listing
May 2007

Neurogenic components of trypsin- and thrombin-induced inflammation in rat skin, in vivo.

Exp Dermatol 2006 Jan;15(1):58-65

Department of Anaesthesiology and Intensive Care, Faculty of Clinical Medicine Mannheim, University of Medicine Heidelberg, Mannheim, Germany.

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http://dx.doi.org/10.1111/j.0906-6705.2005.00392.xDOI Listing
January 2006

IL-1 beta potentiates heat-activated currents in rat sensory neurons: involvement of IL-1RI, tyrosine kinase, and protein kinase C.

FASEB J 2002 Oct;16(12):1497-503

Institut fuer Physiologie und Experimentelle Pathophysiologie, Friedrich-Alexander Universitaet, 91054 Erlangen, Germany.

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http://dx.doi.org/10.1096/fj.02-0101comDOI Listing
October 2002

PKA/AKAP/VR-1 module: A common link of Gs-mediated signaling to thermal hyperalgesia.

J Neurosci 2002 Jun;22(11):4740-5

Institute of Physiology, Department of Anaesthesiology, University of Erlangen, D-91054 Erlangen, Germany.

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http://dx.doi.org/20026461DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6758778PMC
June 2002

Interleukin-6 in combination with its soluble IL-6 receptor sensitises rat skin nociceptors to heat, in vivo.

Pain 2002 Mar;96(1-2):57-62

Institut für Physiologie und Experimentelle Pathophysiologie, Universitätsstrasse 17, Erlangen, Germany.

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http://dx.doi.org/10.1016/s0304-3959(01)00420-1DOI Listing
March 2002