Othmar G Engelhardt

Nanobodies mapped to cross-reactive and divergent epitopes on A(H7N9) influenza hemagglutinin using yeast display.

Authors:

Tiziano Gaiotto Walter Ramage Christina Ball Paul Risley George W Carnell Nigel Temperton Othmar G Engelhardt Simon E Hufton

Sci Rep 2021 Feb 4;11(1):3126. Epub 2021 Feb 4.

Biotherapeutics Division, National Institute for Biological Standards and Control, a Centre of the Medicines and Healthcare Products Regulatory Agency, Blanche Lane, South Mimms, Potters Bar, Herts, EN6 3QG, UK.

View Article and Find Full Text PDF

February 2021

Development and Assessment of a Pooled Serum as Candidate Standard to Measure Influenza A Virus Group 1 Hemagglutinin Stalk-Reactive Antibodies.

Vaccines (Basel) 2020 Nov 9;8(4). Epub 2020 Nov 9.

Department of Microbiology, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1124, New York, NY 10029, USA.

View Article and Find Full Text PDF

November 2020

Protective efficacy of a polyvalent influenza A DNA vaccine against both homologous (H1N1pdm09) and heterologous (H5N1) challenge in the ferret model.

Authors:

Kate Guilfoyle Diane Major Sarah Skeldon Heather James Jeanette L Tingstedt Charlotta Polacek Ria Lassauniére Othmar G Engelhardt Anders Fomsgaard

Vaccine 2020 Oct 6. Epub 2020 Oct 6.

Virus Research and Development Laboratory, Department of Virus and Microbiological Special Diagnostics, Statens Serum Institut, Artillerivej 5, 2300 Copenhagen S, Denmark; Infectious Disease Research Unit, Clinical Institute, University of Southern Denmark, Sdr. Boulevard 29, DK-5000 Odense C, Denmark.

View Article and Find Full Text PDF

October 2020

Protection From Influenza by Intramuscular Gene Vector Delivery of a Broadly Neutralizing Nanobody Does Not Depend on Antibody Dependent Cellular Cytotoxicity.

Authors:

Joanne Marie M Del Rosario Matthew Smith Kam Zaki Paul Risley Nigel Temperton Othmar G Engelhardt Mary Collins Yasuhiro Takeuchi Simon E Hufton

Front Immunol 2020 29;11:627. Epub 2020 May 29.

Division of Biotherapeutics, National Institute for Biological Standards and Control, Potters Bar, United Kingdom.

View Article and Find Full Text PDF

May 2020

Expansion of the 1st WHO international standard for antiserum to respiratory syncytial virus to include neutralisation titres against RSV subtype B: An international collaborative study.

Authors:

Jacqueline U McDonald Peter Rigsby Eleanor Atkinson Othmar G Engelhardt

Vaccine 2020 01 8;38(4):800-807. Epub 2019 Nov 8.

Division of Virology, National Institute for Biological Standards and Control (NIBSC), South Mimms, Potters Bar, Herts EN6 3QG, UK. Electronic address:

View Article and Find Full Text PDF

January 2020

Biosafety risk assessment for production of candidate vaccine viruses to protect humans from zoonotic highly pathogenic avian influenza viruses.

Authors:

Li-Mei Chen Ruben O Donis David L Suarez David E Wentworth Richard Webby Othmar G Engelhardt David E Swayne

Influenza Other Respir Viruses 2020 03 28;14(2):215-225. Epub 2019 Oct 28.

Exotic and Emerging Avian Viral Diseases Research Unit, Agricultural Research Service, U.S. National Poultry Research Center, U.S. Department of Agriculture, Athens, GA, USA.

View Article and Find Full Text PDF

March 2020

Cross-Reactive and Lineage-Specific Single Domain Antibodies against Influenza B Hemagglutinin.

Authors:

Walter Ramage Tiziano Gaiotto Christina Ball Paul Risley George W Carnell Nigel Temperton Chung Y Cheung Othmar G Engelhardt Simon E Hufton

Antibodies (Basel) 2019 Feb 10;8(1). Epub 2019 Feb 10.

Biotherapeutics Division, National Institute for Biological Standards and Control, Blanche Lane, South Mimms, Potters Bar, Hertfordshire EN6 3QG, UK.

View Article and Find Full Text PDF

February 2019

Segment 2 from influenza A(H1N1) 2009 pandemic viruses confers temperature-sensitive haemagglutinin yield on candidate vaccine virus growth in eggs that can be epistatically complemented by PB2 701D.

Authors:

Saira Hussain Matthew L Turnbull Rute M Pinto John W McCauley Othmar G Engelhardt Paul Digard

J Gen Virol 2019 07 6;100(7):1079-1092. Epub 2019 Jun 6.

1 The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Edinburgh, EH25 9RG, UK.

View Article and Find Full Text PDF

July 2019

Cross-Protective Potential and Protection-Relevant Immune Mechanisms of Whole Inactivated Influenza Virus Vaccines Are Determined by Adjuvants and Route of Immunization.

Authors:

Yoshita Bhide Wei Dong Inta Gribonika Daniëlle Voshart Tjarko Meijerhof Jacqueline de Vries-Idema Stephen Norley Kate Guilfoyle Sarah Skeldon Othmar G Engelhardt Louis Boon Dennis Christensen Nils Lycke Anke Huckriede

Front Immunol 2019 29;10:646. Epub 2019 Mar 29.

Department of Medical Microbiology and Infection Prevention, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.

View Article and Find Full Text PDF

August 2020

Establishment of the first WHO International Standard for antiserum to Respiratory Syncytial Virus: Report of an international collaborative study.

Authors:

Jacqueline U McDonald Peter Rigsby Thomas Dougall Othmar G Engelhardt

Vaccine 2018 11 30;36(50):7641-7649. Epub 2018 Oct 30.

Division of Virology, National Institute for Biological Standards and Control (NIBSC), South Mimms, Potters Bar, Herts EN6 3QG, UK. Electronic address:

View Article and Find Full Text PDF

November 2018

Mutation of Influenza A Virus PA-X Decreases Pathogenicity in Chicken Embryos and Can Increase the Yield of Reassortant Candidate Vaccine Viruses.

Authors:

Saira Hussain Matthew L Turnbull Helen M Wise Brett W Jagger Philippa M Beard Kristina Kovacikova Jeffery K Taubenberger Lonneke Vervelde Othmar G Engelhardt Paul Digard

J Virol 2019 01 4;93(2). Epub 2019 Jan 4.

The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Edinburgh, United Kingdom

View Article and Find Full Text PDF

January 2019

Cross-Protective Immune Responses Induced by Sequential Influenza Virus Infection and by Sequential Vaccination With Inactivated Influenza Vaccines.

Authors:

Wei Dong Yoshita Bhide Federica Sicca Tjarko Meijerhof Kate Guilfoyle Othmar G Engelhardt Louis Boon Cornelis A M de Haan George Carnell Nigel Temperton Jacqueline de Vries-Idema David Kelvin Anke Huckriede

Front Immunol 2018 9;9:2312. Epub 2018 Oct 9.

Department of Medical Microbiology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.

View Article and Find Full Text PDF

October 2019

Workshop report: Experimental animal models for universal influenza vaccines.

Authors:

Flavia D'Alessio Gerrit Koopman Sophie Houard Edmond J Remarque Norbert Stockhofe Othmar G Engelhardt

Vaccine 2018 11 16;36(46):6895-6901. Epub 2018 Oct 16.

National Institute for Biological Standards and Control, Medicines and Healthcare Products Regulatory Agency, Blanche Lane, South Mimms, Potters Bar, Hertfordshire EN6 3QG, UK.

View Article and Find Full Text PDF

November 2018

Comparison of single radial immunodiffusion, SDS-PAGE and HPLC potency assays for inactivated influenza vaccines shows differences in ability to predict immunogenicity of haemagglutinin antigen.

Authors:

Othmar G Engelhardt Chantal Edge Una Dunleavy Kate Guilfoyle Ruth Harvey Diane Major Robert Newman Rebecca Penn Sarah Skeldon Claire Storey Jun Wheeler John Wood Philip Minor

Vaccine 2018 07 9;36(29):4339-4345. Epub 2018 Jun 9.

Division of Virology, National Institute for Biological Standards and Control, Blanche Lane, South Mimms, Potters Bar EN6 3QG, UK.

View Article and Find Full Text PDF

July 2018

Report on eighth WHO meeting on development of influenza vaccines that induce broadly protective and long-lasting immune responses: Chicago, USA, 23-24 August 2016.

Authors:

Justin R Ortiz Julian Hickling Rebecca Jones Armen Donabedian Othmar G Engelhardt Jacqueline M Katz Shabir A Madhi Kathleen M Neuzil Guus F Rimmelzwaan James Southern David J Spiro Joachim Hombach

Vaccine 2018 02 6;36(7):932-938. Epub 2017 Dec 6.

Initiative for Vaccine Research, World Health Organization (WHO), Geneva, Switzerland. Electronic address:

View Article and Find Full Text PDF

February 2018

Workshop report: Immunoassay standardisation for "universal" influenza vaccines.

Authors:

Sophia Pavlova Flavia D'Alessio Sophie Houard Edmond J Remarque Norbert Stockhofe Othmar G Engelhardt

Influenza Other Respir Viruses 2017 05 8;11(3):194-201. Epub 2017 Apr 8.

National Institute for Biological Standards and Control, Medicines and Healthcare products Regulatory Agency, South Mimms, Potters Bar, Hertfordshire, UK.

View Article and Find Full Text PDF

May 2017

The Ability of a Non-Egg Adapted (Cell-Like) A(H1N1)pdm09 Virus to Egg-Adapt at HA Loci Other than 222 and 223 and Its Effect on the Yield of Viral Protein.

Authors:

Carolyn Nicolson Ruth Harvey Othmar G Engelhardt James S Robertson

PLoS One 2016 18;11(11):e0166761. Epub 2016 Nov 18.

National Institute for Biological Standards and Control, MHRA, Blanche Lane, South Mimms, Potters Bar, Hertfordshire, EN6 3QG, United Kingdom.

View Article and Find Full Text PDF

June 2017

CONSISE statement on the reporting of Seroepidemiologic Studies for influenza (ROSES-I statement): an extension of the STROBE statement.

Authors:

Peter W Horby Karen L Laurie Benjamin J Cowling Othmar G Engelhardt Katharine Sturm-Ramirez Jose L Sanchez Jacqueline M Katz Timothy M Uyeki John Wood Maria D Van Kerkhove

Influenza Other Respir Viruses 2017 01 9;11(1):2-14. Epub 2016 Aug 9.

Center for Global Health, Institut Pasteur, Paris, France.

View Article and Find Full Text PDF

January 2017

Comparability of neuraminidase inhibition antibody titers measured by enzyme-linked lectin assay (ELLA) for the analysis of influenza vaccine immunogenicity.

Authors:

Maryna C Eichelberger Laura Couzens Yonghong Gao Min Levine Jacqueline Katz Ralf Wagner Catherine I Thompson Katja Höschler Karen Laurie Tian Bai Othmar G Engelhardt John Wood

Vaccine 2016 Jan 18;34(4):458-465. Epub 2015 Dec 18.

Formerly National Institute for Biological Standards and Control, United Kingdom.

View Article and Find Full Text PDF

January 2016

International Laboratory Comparison of Influenza Microneutralization Assays for A(H1N1)pdm09, A(H3N2), and A(H5N1) Influenza Viruses by CONSISE.

Authors:

Karen L Laurie Othmar G Engelhardt John Wood Alan Heath Jacqueline M Katz Malik Peiris Katja Hoschler Olav Hungnes Wenqing Zhang Maria D Van Kerkhove

Clin Vaccine Immunol 2015 Aug 24;22(8):957-64. Epub 2015 Jun 24.

Center for Global Health, Institut Pasteur, Paris, France.

View Article and Find Full Text PDF

August 2015

A promoter mutation in the haemagglutinin segment of influenza A virus generates an effective candidate live attenuated vaccine.

Authors:

Ruth Harvey Rachel E Johnson Kirsty MacLellan-Gibson James S Robertson Othmar G Engelhardt

Influenza Other Respir Viruses 2014 Nov 2;8(6):605-12. Epub 2014 Aug 2.

National Institute for Biological Standards and Control, Medicines and Healthcare products Regulatory Agency, Potters Bar, UK.

View Article and Find Full Text PDF

November 2014

The breadth of cross sub-type neutralisation activity of a single domain antibody to influenza hemagglutinin can be increased by antibody valency.

Authors:

Simon E Hufton Paul Risley Christina R Ball Diane Major Othmar G Engelhardt Stephen Poole

PLoS One 2014 1;9(8):e103294. Epub 2014 Aug 1.

Biotherapeutics Group, National Institute for Biological Standards and Control, a centre of the Medicines and Healthcare Products Regulatory Agency, South Mimms, Potters Bar, Hertfordshire, United Kingdom.

View Article and Find Full Text PDF

April 2015

WHO recommendations for the viruses used in the 2013-2014 Northern Hemisphere influenza vaccine: Epidemiology, antigenic and genetic characteristics of influenza A(H1N1)pdm09, A(H3N2) and B influenza viruses collected from October 2012 to January 2013.

Vaccine 2014 Aug 28;32(37):4713-25. Epub 2014 Feb 28.

WHO Global Influenza Programme (GIP), Geneva, Switzerland.

View Article and Find Full Text PDF

August 2014

The consortium for the standardization of influenza seroepidemiology (CONSISE): a global partnership to standardize influenza seroepidemiology and develop influenza investigation protocols to inform public health policy.

Authors:

Maria D Van Kerkhove Eeva Broberg Othmar G Engelhardt John Wood Angus Nicoll

Influenza Other Respir Viruses 2013 May 26;7(3):231-4. Epub 2012 Dec 26.

MRC Centre for Outbreak Analysis and Modelling, Department of Infectious Disease Epidemiology, Imperial College London, London, UK.

View Article and Find Full Text PDF

May 2013

WHO recommendations for the viruses to be used in the 2012 Southern Hemisphere Influenza Vaccine: epidemiology, antigenic and genetic characteristics of influenza A(H1N1)pdm09, A(H3N2) and B influenza viruses collected from February to September 2011.

Vaccine 2012 Oct 20;30(45):6461-71. Epub 2012 Aug 20.

WHO Collaborating Centre for Surveillance, Epidemiology and Control of Influenza, Influenza Division, Centres for Disease Control and Prevention, NE, Atlanta, GA 30333, USA.

View Article and Find Full Text PDF

October 2012

Many ways to make an influenza virus--review of influenza virus reverse genetics methods.

Authors:

Othmar G Engelhardt

Influenza Other Respir Viruses 2013 May 19;7(3):249-56. Epub 2012 Jun 19.

Division of Virology, National Institute for Biological Standards and Control, Health Protection Agency, Potters Bar, UK.

View Article and Find Full Text PDF

May 2013

Permissible variation in the 3' non-coding region of the haemagglutinin genome segment of the H5N1 candidate influenza vaccine virus NIBRG-14 [corrected].

Authors:

Rachel E Johnson Michelle Hamill Ruth Harvey Carolyn Nicolson James S Robertson Othmar G Engelhardt

PLoS One 2012 11;7(5):e36241. Epub 2012 May 11.

Division of Virology, National Institute for Biological Standards and Control, Health Protection Agency, Blanche Lane, Potters Bar, Hertfordshire, United Kingdom.

View Article and Find Full Text PDF

October 2012

Application of deglycosylation to SDS PAGE analysis improves calibration of influenza antigen standards.

Authors:

Ruth Harvey Michelle Hamill James S Robertson Philip D Minor Galina M Vodeiko Jerry P Weir Hitoshi Takahashi Yuichi Harada Shigeyuki Itamura Pearl Bamford Tania Dalla Pozza Othmar G Engelhardt

Biologicals 2012 Jan 12;40(1):96-9. Epub 2012 Jan 12.

Division of Virology, National Institute for Biological Standards and Control, Health Protection Agency, Blanche Lane, South Mimms, Potters Bar, Hertfordshire EN6 3QG, United Kingdom.

View Article and Find Full Text PDF

January 2012

An additional oligosaccharide moiety in the HA of a pandemic influenza H1N1 candidate vaccine virus confers increased antigen yield in eggs.

Authors:

Carolyn Nicolson Ruth Harvey Rachel Johnson Kate Guilfoyle Othmar G Engelhardt James S Robertson

Vaccine 2012 Jan 30;30(4):745-51. Epub 2011 Nov 30.

Division of Virology, National Institute for Biological Standards and Control, South Mimms, Potters Bar, Hertfordshire, EN6 3QG, UK.

View Article and Find Full Text PDF

January 2012

Characterization of the interaction between the influenza A virus polymerase subunit PB1 and the host nuclear import factor Ran-binding protein 5.

Authors:

Edward C Hutchinson Olivia E Orr Sai Man Liu Othmar G Engelhardt Ervin Fodor

J Gen Virol 2011 Aug 11;92(Pt 8):1859-1869. Epub 2011 May 11.

Sir William Dunn School of Pathology, University of Oxford, Oxford, UK.

View Article and Find Full Text PDF

August 2011

Publications by authors named "Othmar G Engelhardt"

Authors:

Authors:

Authors:

Authors:

Authors:

Authors:

Authors:

Authors:

Authors:

Authors:

Authors:

Authors:

Authors:

Authors:

Authors:

Authors:

Authors:

Authors:

Authors:

Authors:

Authors:

Authors:

Authors:

Authors:

Authors:

Authors:

Authors:

Authors:

Authors:

Authors: