Osvaldo Grana

Osvaldo Grana

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Osvaldo Grana

Publications by authors named "Osvaldo Grana"

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Integrative multi-omics analysis identifies a prognostic miRNA signature and a targetable miR-21-3p/TSC2/mTOR axis in metastatic pheochromocytoma/paraganglioma.

Authors:
Bruna Calsina Luis Jaime Castro-Vega Rafael Torres-Pérez Lucía Inglada-Pérez Maria Currás-Freixes Juan María Roldán-Romero Veronika Mancikova Rocío Letón Laura Remacha María Santos Nelly Burnichon Charlotte Lussey-Lepoutre Elena Rapizzi Osvaldo Graña Cristina Álvarez-Escolá Aguirre A de Cubas Javier Lanillos Alfonso Cordero-Barreal Ángel M Martínez-Montes Alexandre Bellucci Laurence Amar Fabio Luiz Fernandes-Rosa María Calatayud Javier Aller Cristina Lamas Júlia Sastre-Marcos Letizia Canu Esther Korpershoek Henri J Timmers Jacques Wm Lenders Felix Beuschlein Martin Fassnacht-Capeller Graeme Eisenhofer Massimo Mannelli Fátima Al-Shahrour Judith Favier Cristina Rodríguez-Antona Alberto Cascón Cristina Montero-Conde Anne-Paule Gimenez-Roqueplo Mercedes Robledo

Theranostics 2019 9;9(17):4946-4958. Epub 2019 Jul 9.

Hereditary Endocrine Cancer Group, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.

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http://dx.doi.org/10.7150/thno.35458DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6691382PMC
July 2019

TWEAK increases CD74 expression and sensitizes to DDT proinflammatory actions in tubular cells.

Authors:
Lara Valiño-Rivas Leticia Cuarental Osvaldo Grana Richard Bucala Lin Leng Ana Sanz Gonzalo Gomez Alberto Ortiz Maria Dolores Sanchez-Niño

PLoS One 2018 20;13(6):e0199391. Epub 2018 Jun 20.

IIS-Fundacion Jimenez Diaz, Madrid, Spain.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0199391PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6010292PMC
April 2019

Bicycle: a bioinformatics pipeline to analyze bisulfite sequencing data.

Authors:
Osvaldo Graña Hugo López-Fernández Florentino Fdez-Riverola David González Pisano Daniel Glez-Peña

Bioinformatics 2018 04;34(8):1414-1415

Departamento de Informática. ESEI-Escuela Superior de Ingeniería Informática, Edificio Politécnico, Campus Universitario As Lagoas S/N, Universidade de Vigo, 32004 Ourense, Spain.

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http://dx.doi.org/10.1093/bioinformatics/btx778DOI Listing
April 2018

Saa3 is a key mediator of the protumorigenic properties of cancer-associated fibroblasts in pancreatic tumors.

Authors:
Magdolna Djurec Osvaldo Graña Albert Lee Kevin Troulé Elisa Espinet Lavinia Cabras Carolina Navas María Teresa Blasco Laura Martín-Díaz Miranda Burdiel Jing Li Zhaoqi Liu Mireia Vallespinós Francisco Sanchez-Bueno Martin R Sprick Andreas Trumpp Bruno Sainz Fátima Al-Shahrour Raul Rabadan Carmen Guerra Mariano Barbacid

Proc Natl Acad Sci U S A 2018 02 19;115(6):E1147-E1156. Epub 2018 Jan 19.

Molecular Oncology, Centro Nacional de Investigaciones Oncológicas (CNIO), 28029 Madrid, Spain;

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http://dx.doi.org/10.1073/pnas.1717802115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5819438PMC
February 2018

Systems analysis identifies melanoma-enriched pro-oncogenic networks controlled by the RNA binding protein CELF1.

Authors:
Metehan Cifdaloz Lisa Osterloh Osvaldo Graña Erica Riveiro-Falkenbach Pilar Ximénez-Embún Javier Muñoz Cristina Tejedo Tonantzin G Calvo Panagiotis Karras David Olmeda Belén Miñana Gonzalo Gómez-López Estela Cañon Eduardo Eyras Haihong Guo Ferdinand Kappes Pablo L Ortiz-Romero Jose L Rodríguez-Peralto Diego Megías Juan Valcárcel María S Soengas

Nat Commun 2017 12 21;8(1):2249. Epub 2017 Dec 21.

Melanoma Laboratory, Molecular Oncology Programme, Spanish National Cancer Research Center (CNIO), 28029, Madrid, Spain.

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http://dx.doi.org/10.1038/s41467-017-02353-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5740069PMC
December 2017

Genomic and Molecular Screenings Identify Different Mechanisms for Acquired Resistance to MET Inhibitors in Lung Cancer Cells.

Authors:
Pol Gimenez-Xavier Eva Pros Ester Bonastre Sebastian Moran Ana Aza Osvaldo Graña Gonzalo Gomez-Lopez Sophia Derdak Marc Dabad Anna Esteve-Codina Jose R Hernandez Mora Diana Salinas-Chaparro Manel Esteller David Pisano Montse Sanchez-Cespedes

Mol Cancer Ther 2017 07 10;16(7):1366-1376. Epub 2017 Apr 10.

Genes and Cancer Group, Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute-IDIBELL, Hospitalet de Llobregat, Barcelona, Spain.

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http://dx.doi.org/10.1158/1535-7163.MCT-17-0104DOI Listing
July 2017

Inactivation of Capicua in adult mice causes T-cell lymphoblastic lymphoma.

Authors:
Lucía Simón-Carrasco Osvaldo Graña Marina Salmón Harrys K C Jacob Alejandro Gutierrez Gerardo Jiménez Matthias Drosten Mariano Barbacid

Genes Dev 2017 07 21;31(14):1456-1468. Epub 2017 Aug 21.

Molecular Oncology Programme, Centro Nacional de Investigaciones Oncológicas (CNIO), 28029 Madrid, Spain.

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http://dx.doi.org/10.1101/gad.300244.117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5588927PMC
July 2017

Genomic Profiling of Patient-Derived Xenografts for Lung Cancer Identifies Inactivation Impairing Immunorecognition.

Authors:
Carolina Pereira Pol Gimenez-Xavier Eva Pros Maria J Pajares Massimo Moro Antonio Gomez Alejandro Navarro Enric Condom Sebastian Moran Gonzalo Gomez-Lopez Osvaldo Graña Miriam Rubio-Camarillo Alex Martinez-Martí Jun Yokota Julian Carretero Jose M Galbis Ernest Nadal David Pisano Gabriella Sozzi Enriqueta Felip Luis M Montuenga Luca Roz Alberto Villanueva Montse Sanchez-Cespedes

Clin Cancer Res 2017 Jun 16;23(12):3203-3213. Epub 2017 Mar 16.

Genes and Cancer Group, Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), Hospitalet de Llobregat, Barcelona, Spain.

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http://dx.doi.org/10.1158/1078-0432.CCR-16-1946DOI Listing
June 2017

Programmed mitophagy is essential for the glycolytic switch during cell differentiation.

Authors:
Lorena Esteban-Martínez Elena Sierra-Filardi Rebecca S McGreal María Salazar-Roa Guillermo Mariño Esther Seco Sylvère Durand David Enot Osvaldo Graña Marcos Malumbres Ales Cvekl Ana María Cuervo Guido Kroemer Patricia Boya

EMBO J 2017 06 2;36(12):1688-1706. Epub 2017 May 2.

Department of Cellular and Molecular Biology, Centro de Investigaciones Biológicas, CSIC, Madrid, Spain

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http://dx.doi.org/10.15252/embj.201695916DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5470043PMC
June 2017

Whole-body imaging of lymphovascular niches identifies pre-metastatic roles of midkine.

Authors:
David Olmeda Daniela Cerezo-Wallis Erica Riveiro-Falkenbach Paula C Pennacchi Marta Contreras-Alcalde Nuria Ibarz Metehan Cifdaloz Xavier Catena Tonantzin G Calvo Estela Cañón Direna Alonso-Curbelo Javier Suarez Lisa Osterloh Osvaldo Graña Francisca Mulero Diego Megías Marta Cañamero Jorge L Martínez-Torrecuadrada Chandrani Mondal Julie Di Martino David Lora Inés Martinez-Corral J Javier Bravo-Cordero Javier Muñoz Susana Puig Pablo Ortiz-Romero José L Rodriguez-Peralto Sagrario Ortega María S Soengas

Nature 2017 06;546(7660):676-680

Melanoma Laboratory, Molecular Oncology Programme, Spanish National Cancer Research Centre (CNIO), Madrid 28029, Spain.

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http://dx.doi.org/10.1038/nature22977DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6005659PMC
June 2017

Liver carcinogenesis by FOS-dependent inflammation and cholesterol dysregulation.

Authors:
Latifa Bakiri Rainer Hamacher Osvaldo Graña Ana Guío-Carrión Ramón Campos-Olivas Lola Martinez Hans P Dienes Martin K Thomsen Sebastian C Hasenfuss Erwin F Wagner

J Exp Med 2017 05 29;214(5):1387-1409. Epub 2017 Mar 29.

Genes, Development and Disease Group, Cancer Cell Biology Programme, Spanish National Cancer Research Centre (CNIO), E-28029 Madrid, Spain

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http://dx.doi.org/10.1084/jem.20160935DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5413325PMC
May 2017

Hepatocellular Carcinomas Originate Predominantly from Hepatocytes and Benign Lesions from Hepatic Progenitor Cells.

Authors:
Krishna S Tummala Marta Brandt Ana Teijeiro Osvaldo Graña Robert F Schwabe Cristian Perna Nabil Djouder

Cell Rep 2017 04;19(3):584-600

Cancer Cell Biology Programme, Growth Factors, Nutrients and Cancer Group, Centro Nacional de Investigaciones Oncológicas (CNIO), Madrid 28029, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.03.059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5409928PMC
April 2017

Lineage-specific roles of the cytoplasmic polyadenylation factor CPEB4 in the regulation of melanoma drivers.

Authors:
Eva Pérez-Guijarro Panagiotis Karras Metehan Cifdaloz Raúl Martínez-Herranz Estela Cañón Osvaldo Graña Celia Horcajada-Reales Direna Alonso-Curbelo Tonantzin G Calvo Gonzalo Gómez-López Nicolas Bellora Erica Riveiro-Falkenbach Pablo L Ortiz-Romero José L Rodríguez-Peralto Lorena Maestre Giovanna Roncador Juan C de Agustín Asensio Colin R Goding Eduardo Eyras Diego Megías Raúl Méndez María S Soengas

Nat Commun 2016 11 18;7:13418. Epub 2016 Nov 18.

Melanoma Group, Molecular Oncology Programme, Spanish National Cancer Research Centre (CNIO), Madrid 28029, Spain.

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http://dx.doi.org/10.1038/ncomms13418DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5120223PMC
November 2016

NSD2 contributes to oncogenic RAS-driven transcription in lung cancer cells through long-range epigenetic activation.

Authors:
Verónica García-Carpizo Jacinto Sarmentero Bomie Han Osvaldo Graña Sergio Ruiz-Llorente David G Pisano Manuel Serrano Harold B Brooks Robert M Campbell Maria J Barrero

Sci Rep 2016 09 8;6:32952. Epub 2016 Sep 8.

CNIO-Lilly Epigenetics Laboratory, Spanish National Cancer Research Center (CNIO), C/ Melchor Fernández Almagro, 3. 28029 Madrid, Spain.

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http://dx.doi.org/10.1038/srep32952DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5015087PMC
September 2016

Telomeric RNAs are essential to maintain telomeres.

Authors:
Juan José Montero Isabel López de Silanes Osvaldo Graña Maria A Blasco

Nat Commun 2016 08 17;7:12534. Epub 2016 Aug 17.

Telomeres and Telomerase Group, Molecular Oncology Programme, Spanish National Cancer Research Centre (CNIO), 28029 Madrid, Spain.

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http://dx.doi.org/10.1038/ncomms12534DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4992061PMC
August 2016

Deep sequencing reveals microRNAs predictive of antiangiogenic drug response.

Authors:
Jesús García-Donas Benoit Beuselinck Lucía Inglada-Pérez Osvaldo Graña Patrick Schöffski Agnieszka Wozniak Oliver Bechter Maria Apellániz-Ruiz Luis Javier Leandro-García Emilio Esteban Daniel E Castellano Aranzazu González Del Alba Miguel Angel Climent Susana Hernando José Angel Arranz Manuel Morente David G Pisano Mercedes Robledo Cristina Rodriguez-Antona

JCI Insight 2016 07 7;1(10):e86051. Epub 2016 Jul 7.

Hereditary Endocrine Cancer Group, Human Cancer Genetics Programme, Spanish National Cancer Research Centre, Madrid, Spain.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5033860PMC
http://dx.doi.org/10.1172/jci.insight.86051DOI Listing
July 2016

Chronic skin inflammation leads to bone loss by IL-17-mediated inhibition of Wnt signaling in osteoblasts.

Authors:
Özge Uluçkan Maria Jimenez Susanne Karbach Anke Jeschke Osvaldo Graña Johannes Keller Björn Busse Andrew L Croxford Stephanie Finzel Marije Koenders Wim van den Berg Thorsten Schinke Michael Amling Ari Waisman Georg Schett Erwin F Wagner

Sci Transl Med 2016 Mar 16;8(330):330ra37. Epub 2016 Mar 16.

Cancer Cell Biology Program, Spanish National Cancer Research Centre (CNIO), 28029 Madrid, Spain.

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http://dx.doi.org/10.1126/scitranslmed.aad8996DOI Listing
March 2016

MYC/PGC-1α Balance Determines the Metabolic Phenotype and Plasticity of Pancreatic Cancer Stem Cells.

Authors:
Patricia Sancho Emma Burgos-Ramos Alejandra Tavera Tony Bou Kheir Petra Jagust Matthieu Schoenhals David Barneda Katherine Sellers Ramon Campos-Olivas Osvaldo Graña Catarina R Viera Mariia Yuneva Bruno Sainz Christopher Heeschen

Cell Metab 2015 Oct 10;22(4):590-605. Epub 2015 Sep 10.

Centre for Stem Cells in Cancer & Ageing, Barts Cancer Institute, Queen Mary University of London, London EC1M 6BQ, UK; Stem Cells & Cancer Group, Molecular Pathology Programme, Spanish National Cancer Research Centre (CNIO), Madrid 28029, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2015.08.015DOI Listing
October 2015

The pluripotency factor NANOG promotes the formation of squamous cell carcinomas.

Authors:
Adelaida R Palla Daniela Piazzolla Noelia Alcazar Marta Cañamero Osvaldo Graña Gonzalo Gómez-López Orlando Dominguez Marta Dueñas Jesús M Paramio Manuel Serrano

Sci Rep 2015 May 19;5:10205. Epub 2015 May 19.

1] Molecular Oncology Unit, CIEMAT, Madrid 28040, Spain [2] Oncogenomic Unit, Institute of Biomedical Research, University Hospital "12 de Octubre", Madrid 28040, Spain.

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http://dx.doi.org/10.1038/srep10205DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4437308PMC
May 2015

The contribution of cohesin-SA1 to gene expression and chromatin architecture in two murine tissues.

Authors:
Ana Cuadrado Silvia Remeseiro Osvaldo Graña David G Pisano Ana Losada

Nucleic Acids Res 2015 Mar 3;43(6):3056-67. Epub 2015 Mar 3.

Chromosome Dynamics Group, Molecular Oncology Programme, Spanish National Cancer Research Centre (CNIO), Melchor Fernández Almagro 3, 28029 Madrid, Spain

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http://dx.doi.org/10.1093/nar/gkv144DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4381060PMC
March 2015

Nuclear DICKKOPF-1 as a biomarker of chemoresistance and poor clinical outcome in colorectal cancer.

Authors:
Óscar Aguilera José Manuel González-Sancho Sandra Zazo Raúl Rincón Agustín F Fernández Olga Tapia Francesc Canals Beatriz Morte Vincenzo Calvanese José L Orgaz Núria Niell Susana Aguilar José M Freije Osvaldo Graña David G Pisano Aurea Borrero Javier Martínez-Useros Benilde Jiménez Mario F Fraga Jesús García-Foncillas Carlos López-Otín Miguel Lafarga Federico Rojo Alberto Muñoz

Oncotarget 2015 Mar;6(8):5903-17

Instituto de Investigaciones Biomédicas "Alberto Sols", Consejo Superior de Investigaciones Científicas (CSIC), Universidad Autónoma de Madrid, Madrid, Spain.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4467410PMC
http://dx.doi.org/10.18632/oncotarget.3464DOI Listing
March 2015

Inhibition of de novo NAD(+) synthesis by oncogenic URI causes liver tumorigenesis through DNA damage.

Authors:
Krishna S Tummala Ana L Gomes Mahmut Yilmaz Osvaldo Graña Latifa Bakiri Isabel Ruppen Pilar Ximénez-Embún Vinayata Sheshappanavar Manuel Rodriguez-Justo David G Pisano Erwin F Wagner Nabil Djouder

Cancer Cell 2014 Dec 20;26(6):826-839. Epub 2014 Nov 20.

Growth Factors, Nutrients and Cancer Group, BBVA Foundation-Cancer Cell Biology Programme, Spanish National Cancer Research Centre, CNIO, 28029 Madrid, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2014.10.002DOI Listing
December 2014

Identification of TERRA locus unveils a telomere protection role through association to nearly all chromosomes.

Authors:
Isabel López de Silanes Osvaldo Graña Maria Luigia De Bonis Orlando Dominguez David G Pisano Maria A Blasco

Nat Commun 2014 Sep 3;5:4723. Epub 2014 Sep 3.

Telomeres and Telomerase Group, Spanish National Cancer Research Centre (CNIO), C/Melchor Fernández Almagro, 3, 28029 Madrid, Spain.

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http://www.nature.com/articles/ncomms5723
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http://dx.doi.org/10.1038/ncomms5723DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4164772PMC
September 2014

RAB7 controls melanoma progression by exploiting a lineage-specific wiring of the endolysosomal pathway.

Authors:
Direna Alonso-Curbelo Erica Riveiro-Falkenbach Eva Pérez-Guijarro Metehan Cifdaloz Panagiotis Karras Lisa Osterloh Diego Megías Estela Cañón Tonantzin G Calvo David Olmeda Gonzalo Gómez-López Osvaldo Graña Víctor Javier Sánchez-Arévalo Lobo David G Pisano Hao-Wei Wang Pablo Ortiz-Romero Damià Tormo Keith Hoek José L Rodríguez-Peralto Johanna A Joyce María S Soengas

Cancer Cell 2014 Jul 26;26(1):61-76. Epub 2014 Jun 26.

Melanoma Laboratory, Molecular Oncology Programme, Spanish National Cancer Research Centre (CNIO), Madrid 28029, Spain. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15356108140021
Publisher Site
http://dx.doi.org/10.1016/j.ccr.2014.04.030DOI Listing
July 2014

PLCG1 mutations in cutaneous T-cell lymphomas.

Authors:
José P Vaqué Gonzalo Gómez-López Verónica Monsálvez Ignacio Varela Nerea Martínez Cristina Pérez Orlando Domínguez Osvaldo Graña José L Rodríguez-Peralto Socorro M Rodríguez-Pinilla Carmen González-Vela Miriam Rubio-Camarillo Esperanza Martín-Sánchez David G Pisano Evangelia Papadavid Theodora Papadaki Luis Requena José A García-Marco Miriam Méndez Mariano Provencio Mercedes Hospital Dolores Suárez-Massa Concepción Postigo David San Segundo Marcos López-Hoyos Pablo L Ortiz-Romero Miguel A Piris Margarita Sánchez-Beato

Blood 2014 Mar 4;123(13):2034-43. Epub 2014 Feb 4.

Instituto Formación Investigación Hospital Universitario Marqués de Valdecilla, Santander, Spain;

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http://dx.doi.org/10.1182/blood-2013-05-504308DOI Listing
March 2014

Reprogramming in vivo produces teratomas and iPS cells with totipotency features.

Authors:
María Abad Lluc Mosteiro Cristina Pantoja Marta Cañamero Teresa Rayon Inmaculada Ors Osvaldo Graña Diego Megías Orlando Domínguez Dolores Martínez Miguel Manzanares Sagrario Ortega Manuel Serrano

Nature 2013 Oct 11;502(7471):340-5. Epub 2013 Sep 11.

Tumour Suppression Group, Spanish National Cancer Research Centre (CNIO), Madrid E-28029, Spain.

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http://dx.doi.org/10.1038/nature12586DOI Listing
October 2013

New mutations in chronic lymphocytic leukemia identified by target enrichment and deep sequencing.

Authors:
Elena Doménech Gonzalo Gómez-López Daniel Gzlez-Peña Mar López Beatriz Herreros Juliane Menezes Natalia Gómez-Lozano Angel Carro Osvaldo Graña David G Pisano Orlando Domínguez José A García-Marco Miguel A Piris Margarita Sánchez-Beato

PLoS One 2012 1;7(6):e38158. Epub 2012 Jun 1.

Molecular Pathology Programme, Spanish National Cancer Research Centre, CNIO, Madrid, Spain.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0038158PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3365884PMC
October 2012

A DNA methylation fingerprint of 1628 human samples.

Authors:
Agustin F Fernandez Yassen Assenov Jose Ignacio Martin-Subero Balazs Balint Reiner Siebert Hiroaki Taniguchi Hiroyuki Yamamoto Manuel Hidalgo Aik-Choon Tan Oliver Galm Isidre Ferrer Montse Sanchez-Cespedes Alberto Villanueva Javier Carmona Jose V Sanchez-Mut Maria Berdasco Victor Moreno Gabriel Capella David Monk Esteban Ballestar Santiago Ropero Ramon Martinez Marta Sanchez-Carbayo Felipe Prosper Xabier Agirre Mario F Fraga Osvaldo Graña Luis Perez-Jurado Jaume Mora Susana Puig Jaime Prat Lina Badimon Annibale A Puca Stephen J Meltzer Thomas Lengauer John Bridgewater Christoph Bock Manel Esteller

Genome Res 2012 Feb 25;22(2):407-19. Epub 2011 May 25.

Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet, 08908 Barcelona, Catalonia, Spain.

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http://genome.cshlp.org/cgi/doi/10.1101/gr.119867.110
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http://dx.doi.org/10.1101/gr.119867.110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3266047PMC
February 2012

Long-range epigenetic silencing associates with deregulation of Ikaros targets in colorectal cancer cells.

Authors:
Biola M Javierre Javier Rodriguez-Ubreva Fatima Al-Shahrour Marina Corominas Osvaldo Graña Laura Ciudad Xabier Agirre David G Pisano Alfonso Valencia Jose Roman-Gomez Maria Jose Calasanz Felipe Prosper Manel Esteller Rogelio Gonzalez-Sarmiento Esteban Ballestar

Mol Cancer Res 2011 Aug 7;9(8):1139-51. Epub 2011 Jul 7.

Chromatin and Disease Group, Cancer Epigenetics and Biology Programme, Bellvitge Biomedical Research Institute, Barcelona, Spain.

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http://dx.doi.org/10.1158/1541-7786.MCR-10-0515DOI Listing
August 2011

The REGIA database (RegiaDB): status, limitations and future developments.

Authors:
Ramon Alonso-Allende José M Fernández-González Osvaldo Graña Alfonso Valencia

Comp Funct Genomics 2002 ;3(2):109-14

Protein Design Group, National Center for Biotechnology, CNB-CSIC Cantoblanco, Madrid E-28049, Spain.

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http://dx.doi.org/10.1002/cfg.144DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2447265PMC
June 2010

MidA is a putative methyltransferase that is required for mitochondrial complex I function.

Authors:
Sergio Carilla-Latorre M Esther Gallardo Sarah J Annesley Javier Calvo-Garrido Osvaldo Graña Sandra L Accari Paige K Smith Alfonso Valencia Rafael Garesse Paul R Fisher Ricardo Escalante

J Cell Sci 2010 May 20;123(Pt 10):1674-83. Epub 2010 Apr 20.

Instituto de Investigaciones Biomédicas Alberto Sols (CSIC-UAM), Arturo Duperier 4, 28029 Madrid, Spain.

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http://dx.doi.org/10.1242/jcs.066076DOI Listing
May 2010

Assessment of domain boundary predictions and the prediction of intramolecular contacts in CASP8.

Authors:
Iakes Ezkurdia Osvaldo Graña José M G Izarzugaza Michael L Tress

Proteins 2009 ;77 Suppl 9:196-209

Structural Biology and Biocomputing Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.

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http://dx.doi.org/10.1002/prot.22554DOI Listing
January 2010

The dynamic DNA methylomes of double-stranded DNA viruses associated with human cancer.

Authors:
Agustin F Fernandez Cecilia Rosales Pilar Lopez-Nieva Osvaldo Graña Esteban Ballestar Santiago Ropero Jesus Espada Sonia A Melo Amaia Lujambio Mario F Fraga Irene Pino Biola Javierre Francisco J Carmona Francesco Acquadro Renske D M Steenbergen Peter J F Snijders Chris J Meijer Pascal Pineau Anne Dejean Belen Lloveras Gabriel Capella Josep Quer Maria Buti Juan-Ignacio Esteban Helena Allende Francisco Rodriguez-Frias Xavier Castellsague Janos Minarovits Jordi Ponce Daniela Capello Gianluca Gaidano Juan Cruz Cigudosa Gonzalo Gomez-Lopez David G Pisano Alfonso Valencia Miguel Angel Piris Francesc X Bosch Ellen Cahir-McFarland Elliott Kieff Manel Esteller

Genome Res 2009 Mar 10;19(3):438-51. Epub 2009 Feb 10.

Cancer Epigenetics Group, Spanish National Cancer Research Centre (CNIO), Madrid E-28029, Spain.

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http://dx.doi.org/10.1101/gr.083550.108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2661803PMC
March 2009

Assessment of intramolecular contact predictions for CASP7.

Authors:
José M G Izarzugaza Osvaldo Graña Michael L Tress Alfonso Valencia Neil D Clarke

Proteins 2007 ;69 Suppl 8:152-8

Structural Biology and Biocomputing Programme, Spanish National Cancer Research Centre, 3E-28029 Madrid, Spain.

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http://dx.doi.org/10.1002/prot.21637DOI Listing
January 2008

Assessment of predictions submitted for the CASP6 comparative modeling category.

Authors:
Michael Tress Iakes Ezkurdia Osvaldo Graña Gonzalo López Alfonso Valencia

Proteins 2005 ;61 Suppl 7:27-45

Protein Design Group, CNB-CSIC, Cantoblanco, Madrid, Spain.

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http://dx.doi.org/10.1002/prot.20720DOI Listing
May 2006

CASP6 assessment of contact prediction.

Authors:
Osvaldo Graña David Baker Robert M MacCallum Jens Meiler Marco Punta Burkhard Rost Michael L Tress Alfonso Valencia

Proteins 2005 ;61 Suppl 7:214-24

Protein Design Group, Centro Nacional de Biotecnologia (CNB-CSIC), C/Darwin 3, Cantoblanco, Madrid, Spain.

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http://dx.doi.org/10.1002/prot.20739DOI Listing
May 2006

Scoring docking models with evolutionary information.

Authors:
Michael Tress David de Juan Osvaldo Graña Manuel J Gómez Paulino Gómez-Puertas Jose M González Gonzalo López Alfonso Valencia

Proteins 2005 Aug;60(2):275-80

Protein Design Group, CNB-CSIC, Cantoblanco, Madrid, Spain.

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http://dx.doi.org/10.1002/prot.20570DOI Listing
August 2005

EVAcon: a protein contact prediction evaluation service.

Authors:
Osvaldo Graña Volker A Eyrich Florencio Pazos Burkhard Rost Alfonso Valencia

Nucleic Acids Res 2005 Jul;33(Web Server issue):W347-51

Protein Design Group, Centro Nacional de Biotecnologia (CNB-CSIC) Cantoblanco, 28049 Madrid, Spain.

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http://dx.doi.org/10.1093/nar/gki411DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1160172PMC
July 2005

SQUARE--determining reliable regions in sequence alignments.

Authors:
Michael L Tress Osvaldo Graña Alfonso Valencia

Bioinformatics 2004 Apr 5;20(6):974-5. Epub 2004 Feb 5.

CNB-CSIC, Calle Darwin, Cantoblanco, 28049 Madrid, Spain.

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http://dx.doi.org/10.1093/bioinformatics/bth032DOI Listing
April 2004

CAFASP3 in the spotlight of EVA.

Authors:
Volker A Eyrich Dariusz Przybylski Ingrid Y Y Koh Osvaldo Grana Florencio Pazos Alfonso Valencia Burkhard Rost

Proteins 2003 ;53 Suppl 6:548-60

CUBIC, Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York 10032, USA.

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http://dx.doi.org/10.1002/prot.10534DOI Listing
January 2004

EVA: Evaluation of protein structure prediction servers.

Authors:
Ingrid Y Y Koh Volker A Eyrich Marc A Marti-Renom Dariusz Przybylski Mallur S Madhusudhan Narayanan Eswar Osvaldo Graña Florencio Pazos Alfonso Valencia Andrej Sali Burkhard Rost

Nucleic Acids Res 2003 Jul;31(13):3311-5

Columbia University Center for Computational Biology and Bioinformatics (C2B2), Russ Berrie Pavilion, 1150 St Nicholas Avenue, New York, NY 10032, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC169025PMC
http://dx.doi.org/10.1093/nar/gkg619DOI Listing
July 2003