Dr. Osvaldo Contreras, PhD - Pontificia Universidad Católica de Chile

Dr. Osvaldo Contreras

PhD

Pontificia Universidad Católica de Chile

Santiago | Chile

Main Specialties: Biology, Cardiovascular Disease, Neuromuscular Medicine

Additional Specialties: Developmental biology, skeletal muscle, cell biology, molecular biology, life sciences

ORCID logohttps://orcid.org/0000-0002-8722-9371


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Dr. Osvaldo Contreras, PhD - Pontificia Universidad Católica de Chile

Dr. Osvaldo Contreras

PhD

Introduction

I started my journey as an undergraduate researcher in Juan Larrain’s Lab. There I studied the developmental role of the Wnt/PCP pathway in neural tube closure, by investigating the interplay between Van Gogh Like-2 and Syndecan-4. Then, I moved to work with skeletal muscle mesenchymal progenitor cells and to study their role in muscular dystrophy, regeneration, and tissue fibrosis in Enrique Brandan’s Lab. I'm also interested in the regulation of fibroblasts fate and myogenic differentiation.

Then, I traveled to Vancouver to work at the University of British Columbia in Fabio Rossi's Lab in a Co-op project involving the study of fibro-adipogenic progenitors (FAPs) biology and to understand their role in tissue regeneration and their responses to transforming growth factor type beta (TGF-B signaling pathway).

I finished my Ph.D. Thesis titled: "Role of mesenchymal fibro/adipogenic progenitors in homeostasis and disease: from signaling to fibrosis" in May this year (2019). Now, I'm working as a Postdoctoral Researcher in Brandan's Lab. My next step in my early-career is going to happen in Sydney, Australia. There, I'll continue with my Postdoctoral studies in heart development and repair.

I hope you like fibroblasts and stromal progenitor cells!

Would you like to take a look of my thoughts about our last work on the TGF-B/PDGFRA interplay regulating the fate of skeletal muscle & heart fibroblasts/MSCs?

To do so, please, visit my last "First Person" interview from Journal of Cell Science:

https://jcs.biologists.org/content/132/19/jcs238485

Primary Affiliation: Pontificia Universidad Católica de Chile - Santiago , Chile

Specialties:

Additional Specialties:

Research Interests:


View Dr. Osvaldo Contreras’s Resume / CV

Education

May 2019
Pontificia Universidad Católica de Chile
PhD
Cell
Feb 2018 - Sep 2018
University of British Columbia
PhD Candidate
Biomedical Research Center
Mar 2014 - Aug 2015
Pontificia Universidad Católica de Chile
M. Sc. Molecular and Cellular Biology
Biología Celular y Molecular
Mar 2008 - Aug 2012
Pontificia Universidad Católica de Chile
B. Sc. Biology
Biología Celular y Molecular

Publications

13Publications

395Reads

77Profile Views

24PubMed Central Citations

TGF-β-driven downregulation of the transcription factor TCF7L2 affects Wnt/β-catenin signaling in PDGFRα fibroblasts.

J Cell Sci 2020 Jun 19;133(12). Epub 2020 Jun 19.

Departamento de Biología Celular y Molecular and Center for Aging and Regeneration (CARE-ChileUC), Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, 8331150 Santiago, Chile

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http://dx.doi.org/10.1242/jcs.242297DOI Listing
June 2020
5.432 Impact Factor

Single-cell revolution unveils the mysteries of the regenerative mammalian digit tip.

Dev Biol 2020 May 5;461(2):107-109. Epub 2020 Feb 5.

Developmental and Stem Cell Biology Division, Victor Chang Cardiac Research Institute, Darlinghurst, NSW, 2010, Australia; Departamento de Biología Celular y Molecular, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, 8331150, Santiago, Chile. Electronic address:

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http://dx.doi.org/10.1016/j.ydbio.2020.02.002DOI Listing
May 2020
3.547 Impact Factor

Hic1 deletion unleashes quiescent connective tissue stem cells and impairs skeletal muscle regeneration.

J Cell Commun Signal 2020 Mar 21;14(1):131-133. Epub 2019 Dec 21.

Departamento de Biología Celular y Molecular, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, 8331150, Santiago, Chile.

Skeletal muscle fibro-adipogenic progenitors (FAPs) are tissue-resident connective tissue cells and the main cellular source of pathological fibro-fatty scar associated with muscle disorders. Although our knowledge about skeletal muscle mesenchymal progenitor cells has exploded in the past decade, we still lack information about their origin, fate, gene regulation, function, and stemness. A recent study by Underhill and colleagues, published in Cell Stem Cell, described the last census of Hic1 mesenchymal progenitor/stem cells in skeletal muscle regeneration, providing valuable results and data to the ever-expanding community of scientists interested in tissue regeneration and fibrosis. This commentary contextualizes and summarizes these exciting new findings.

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http://dx.doi.org/10.1007/s12079-019-00545-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7176797PMC
March 2020
5 Reads
3.600 Impact Factor

Cross-talk between TGF-β and PDGFRα signaling pathways regulates the fate of stromal fibro-adipogenic progenitors.

J Cell Sci 2019 10 9;132(19). Epub 2019 Oct 9.

Departamento de Biología Celular y Molecular and Center for Aging and Regeneration (CARE-ChileUC), Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, 8331150 Santiago, Chile

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http://dx.doi.org/10.1242/jcs.232157DOI Listing
October 2019
1 Read
5.432 Impact Factor

Denervation-induced skeletal muscle fibrosis is mediated by CTGF/CCN2 independently of TGF-β.

Matrix Biol 2019 09 1;82:20-37. Epub 2019 Feb 1.

Centro de Envejecimiento y Regeneración, CARE Chile UC, Chile; Departamento de Biología Celular y Molecular, Chile. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S0945053X183045
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http://dx.doi.org/10.1016/j.matbio.2019.01.002DOI Listing
September 2019
13 Reads
5.074 Impact Factor

Expression of CTGF/CCN2 in response to LPA is stimulated by fibrotic extracellular matrix via the integrin/FAK axis.

Am J Physiol Cell Physiol 2018 04 27;314(4):C415-C427. Epub 2017 Dec 27.

Centro de Envejecimiento y Regeneración, CARE Chile UC, and Departamento de Biología Celular y Molecular, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile , Santiago , Chile.

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http://dx.doi.org/10.1152/ajpcell.00013.2017DOI Listing
April 2018
2 Reads
3.780 Impact Factor

Nilotinib impairs skeletal myogenesis by increasing myoblast proliferation.

Skelet Muscle 2018 02 20;8(1). Epub 2018 Feb 20.

Departamento de Biología Celular y Molecular and Center for Aging and Regeneration (CARE-ChileUC), Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Libertador Bernardo O'Higgins 340, 8331150, Santiago, Chile.

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http://dx.doi.org/10.1186/s13395-018-0150-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5819301PMC
February 2018
296 Reads

Fibro/adipogenic progenitors safeguard themselves: a novel mechanism to reduce fibrosis is discovered.

J Cell Commun Signal 2017 Mar 20;11(1):77-78. Epub 2016 Dec 20.

Faculty of Biological Sciences, Pontificia Universidad Católica de Chile, Libertador Bernardo O'Higgins 340, Postal Code 8331150, Santiago, Chile.

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http://dx.doi.org/10.1007/s12079-016-0372-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5362578PMC
March 2017
2 Reads
1 Citation

Connective tissue cells expressing fibro/adipogenic progenitor markers increase under chronic damage: relevance in fibroblast-myofibroblast differentiation and skeletal muscle fibrosis.

Cell Tissue Res 2016 06 7;364(3):647-660. Epub 2016 Jan 7.

Center for Aging and Regeneration, CARE Chile UC and Department of Cell and Molecular Biology, Faculty of Biological Sciences, Pontificia Universidad Católica de Chile, Libertador Bernardo O´Higgins 340, 8331150, Santiago, Chile.

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http://dx.doi.org/10.1007/s00441-015-2343-0DOI Listing
June 2016
20 Reads
9 Citations
3.565 Impact Factor

RECK-Mediated β1-Integrin Regulation by TGF-β1 Is Critical for Wound Contraction in Mice.

PLoS One 2015 6;10(8):e0135005. Epub 2015 Aug 6.

Centro de Regeneración y Envejecimiento (CARE), Departamento de Biología Celular y Molecular, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago, Chile.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0135005PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4527692PMC
May 2016
8 Reads
2 Citations
3.234 Impact Factor

Transforming growth factor type-β inhibits Mas receptor expression in fibroblasts but not in myoblasts or differentiated myotubes; Relevance to fibrosis associated to muscular dystrophies.

Biofactors 2015 Mar-Apr;41(2):111-20. Epub 2015 Mar 23.

Center for Aging and Regeneration, CARE Chile-UC and Department of Cell and Molecular Biology, Faculty of Biological Sciences, Pontificia Universidad Católica de Chile, Santiago, Chile.

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http://dx.doi.org/10.1002/biof.1208DOI Listing
January 2016
11 Reads
4.592 Impact Factor

Erratum for: Transforming growth factor type-β inhibits Mas receptor expression in fibroblasts but not in myoblasts or differentiated myotubes; Relevance to fibrosis associated to muscular dystrophies.

Biofactors 2015 May 12;41(3):209. Epub 2015 Jun 12.

Center for Aging and Regeneration, CARE Chile-UC and Department of Cell and Molecular Biology, Faculty of Biological Sciences, Pontificia Universidad Católica de Chile, Santiago, Chile.

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http://dx.doi.org/10.1002/biof.1220DOI Listing
May 2015
16 Reads
4.592 Impact Factor

Syndecan 4 interacts genetically with Vangl2 to regulate neural tube closure and planar cell polarity.

Development 2013 Jul 12;140(14):3008-17. Epub 2013 Jun 12.

Center for Aging and Regeneration, Millennium Nucleus in Regenerative Biology, Faculty of Biological Sciences, P. Universidad Católica de Chile, Alameda 340 Santiago, Chile.

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http://dx.doi.org/10.1242/dev.091173DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3699283PMC
July 2013
21 Reads
12 Citations
6.462 Impact Factor

Top co-authors

Enrique Brandan
Enrique Brandan

Pontificia Universidad Católica de Chile

10
Daniela L Rebolledo
Daniela L Rebolledo

Center for Aging and Regeneration

2
Claudio Cabello-Verrugio
Claudio Cabello-Verrugio

Centro de Regulación Celular y Patología

2
Hesham Soliman
Hesham Soliman

University of British Columbia

2
Cecilia Riquelme
Cecilia Riquelme

University of Colorado-Boulder

2
Marine Theret
Marine Theret

Université Claude Bernard Lyon 1

2
Catalina Cofre
Catalina Cofre

Center for Aging and Regeneration

2
Maria Gabriela Morales
Maria Gabriela Morales

Centro de Regulación Celular y Patología (CRCP)

2