Publications by authors named "Ossama Abbas"

186 Publications

Primary Localized Cutaneous Amyloidosis of Keratinocyte Origin: An Update with Emphasis on Atypical Clinical Variants.

Am J Clin Dermatol 2021 Sep 21;22(5):667-680. Epub 2021 Jul 21.

Department of Dermatology, American University of Beirut Medical Center, Riad El Solh/Beirut, P.O. Box 11-0236, Beirut, 1107 2020, Lebanon.

Amyloid is a protein derived from at least 20 different substances. Once misfolded, it results in a group of cutaneous and systemic conditions. Primary localized cutaneous amyloidosis of keratinocyte origin is a very common subtype that can manifest either as lichen or macular amyloidosis, lacking systemic involvement. Lichen amyloidosis often presents as multiple hyperpigmented papules on the lower extremities whereas macular amyloidosis is classically characterized by dark brown rippled macules on the interscapular area. Review of the literature reveals that in addition to the classical presentation of primary localized cutaneous amyloidosis there exists a plethora of various manifestations that can be grouped into either geographic or morphologic categories. This review provides clinicians with the intimate knowledge of these presentations and summarizes the available treatment modalities.
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http://dx.doi.org/10.1007/s40257-021-00620-9DOI Listing
September 2021

Localized depression on the buttock in a girl.

Pediatr Dermatol 2021 05;38(3):e20-e21

Department of Dermatology, American University of Beirut Medical Center, Beirut, Lebanon.

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http://dx.doi.org/10.1111/pde.14575DOI Listing
May 2021

Genodermatoses with hearing impairment.

J Am Acad Dermatol 2021 Oct 19;85(4):931-944. Epub 2021 Jun 19.

Department of Dermatology, American University of Beirut Medical Centre, Beirut, Lebanon; Department of Biochemistry and Molecular Genetics, American University of Beirut, Beirut, Lebanon; Division of Genomics and Translational Biomedicine, College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Electronic address:

Hearing loss is a prominent feature in multiple genodermatoses. Underappreciation of auditory deficits can misdirect proper diagnosis by the treating dermatologist. This review reviews the anatomic, developmental, and embryologic aspects that characterize the ear and summarizes genodermatoses that have aberrant auditory findings. The latter are classified into neural crest, metabolic, pigmentary, craniofacial, and a miscellaneous category of disorders lacking specific cutaneous findings. The algorithms provided in this review enable treating dermatologists to better recognize and manage genodermatoses with ear involvement.
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http://dx.doi.org/10.1016/j.jaad.2021.06.850DOI Listing
October 2021

Rapidly Growing Red Nodule on the Scalp.

Am Fam Physician 2021 06;103(12):755-756

American University of Beirut Medical Center, Beirut, Lebanon.

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June 2021

Pityriasis rosea after mRNA COVID-19 vaccination.

Int J Dermatol 2021 Sep 10;60(9):1150-1151. Epub 2021 Jun 10.

Dermatology Department, American University of Beirut Medical Center, Beirut, Lebanon.

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http://dx.doi.org/10.1111/ijd.15700DOI Listing
September 2021

Adnexotropic Variants of the Interface Dermatitides: A Review.

Dermatopathology (Basel) 2021 May 21;8(2):135-146. Epub 2021 May 21.

Department of Dermatology, Boston University School of Medicine, Boston, MA 02118-2415, USA.

The interface dermatitides encompass a vast array of cutaneous entities which, at times, may present with particular clinical variants with adnexal predilection. Similarly, hair follicle and eccrine gland involvement of some of these entities has been observed on histopathology. This review aims to describe the various adnexotropic presentations of the interface dermatitides. Recognizing that the adnexa can be a frequent site of involvement of these conditions may aid dermatopathologists in making the correct diagnosis and avoid misinterpreting adnexotropism for other conditions such as the great imitator, mycosis fungoides.
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http://dx.doi.org/10.3390/dermatopathology8020020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8161827PMC
May 2021

Characterizing the presence of neutrophil extracellular traps in neutrophilic dermatoses.

Exp Dermatol 2021 Jul 9;30(7):988-994. Epub 2021 May 9.

Department of Dermatology, American University of Beirut Medical Center, Beirut, Lebanon.

Neutrophil extracellular traps (NETs) are implicated in the pathogenesis of multiple inflammatory dermatoses. However, characterization of NETs in neutrophilic dermatoses was performed on very limited number of patients; this limitation precluded definitive conclusions. In this case series of 57 patients, we compared the amounts of neutrophils producing NETs in cutaneous lesions of different entities of neutrophilic dermatoses (17 with pyoderma gangrenosum, 37 with Sweet's syndrome and three with subcorneal pustular dermatosis). NETs were identified by double immunofluorescence on formalin-fixed paraffin-embedded skin biopsies using antibodies against elastase and citrullinated histone 3. Percentages of neutrophils showing NETs were high across all three entities (62.9% in PG, 48.5% in SS and 37.8% in subcorneal pustular dermatosis). The differences in mean percentages were significant between entities, with PG showing significantly superior percentage of NETs compared with SS. In our series, 15.8% of neutrophilic dermatoses were associated with malignancies, 10.5% with autoimmune diseases and 73.7% were idiopathic. Percentages of NETs were not statistically different between aetiologies. These findings suggest that NETs are abundantly produced in the various entities and different aetiologies of neutrophilic dermatoses. In comparison with SS, the superior percentage of NETs in PG is clinically mirrored in its greater ulceronecrotic nature.
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http://dx.doi.org/10.1111/exd.14360DOI Listing
July 2021

Genodermatoses with behavioural sequelae.

Postgrad Med J 2021 Apr 29. Epub 2021 Apr 29.

Department of Dermatology, American University of Beirut Medical Center, Beirut, Lebanon

Children with genodermatoses are at an increased risk of developing behavioural disorders which may impart lasting damage on the individual and their family members. As such, early recognition of childhood mental health disorders via meticulous history taking, thorough physical examination, and disorder-specific testing is of paramount importance for timely and effective intervention. If carried out properly, prompt psychiatric screening and intervention can effectively mitigate, prevent or even reverse, the psychiatric sequela in question. To that end, this review aims to inform the concerned physician of the manifestations and treatment strategies relevant to the psychological sequelae of genodermatoses.
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http://dx.doi.org/10.1136/postgradmedj-2020-139539DOI Listing
April 2021

Herpes zoster emergence following mRNA COVID-19 vaccine.

J Med Virol 2021 Sep 3;93(9):5231-5232. Epub 2021 May 3.

Dermatology Department, American University of Beirut Medical Center, Beirut, Lebanon.

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http://dx.doi.org/10.1002/jmv.27036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8242521PMC
September 2021

Imatinib-induced eruptive nevi.

Clin Exp Pharmacol Physiol 2021 09 25;48(9):1298-1299. Epub 2021 Mar 25.

Department of Dermatology, American University of Beirut Medical Centre, Beirut, Lebanon.

Imatinib mesylate is a tyrosine kinase inhibitor used in the treatment of a variety of oncological conditions. It has been associated with a spectrum of pigmentary cutaneous side effects. Despite the well-known association of eruptive melanocytic nevi with the use of other tyrosine kinase inhibitors, this phenomenon has not been linked to the administration of imatinib. We present the first case of imatinib-induced eruptive nevi in an 18-year-old patient with acute lymphocytic leukaemia in remission.
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http://dx.doi.org/10.1111/1440-1681.13491DOI Listing
September 2021

A necrotic arm with a palpable pulse.

Int J Dermatol 2021 Jul 17;60(7):e253-e255. Epub 2021 Mar 17.

Department of Dermatology, American University of Beirut Medical Center, Beirut, Lebanon.

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http://dx.doi.org/10.1111/ijd.15477DOI Listing
July 2021

Plasmacytoid dendritic cells and type I interferons in flares of systemic lupus erythematosus triggered by COVID-19.

Rheumatol Int 2021 05 5;41(5):1019-1020. Epub 2021 Mar 5.

Department of Dermatology, American University of Beirut Medical Center, P.O. Box 11-0236, Riad El Solh, 1107 2020, Lebanon.

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http://dx.doi.org/10.1007/s00296-021-04825-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7933913PMC
May 2021

Reply to "Immune checkpoint inhibitor-related dermatologic adverse events".

J Am Acad Dermatol 2021 06 1;84(6):e297-e298. Epub 2021 Mar 1.

Department of Dermatology, American University of Beirut Medical Center, Beirut, Lebanon. Electronic address:

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http://dx.doi.org/10.1016/j.jaad.2021.02.064DOI Listing
June 2021

Osteoclast-Like Giant Cells: Focus on Entities Relevant to Dermatopathology and Underlying Pathogenesis.

Am J Dermatopathol 2021 Mar;43(3):163-173

Professor, Dermatopathology Section, Department of Dermatology, Boston University School of Medicine, Boston, MA.

Abstract: Osteoclast-like giant cells (OLGCs) resemble osteoclasts with their abundant cytoplasm and well-developed organelles. OLGCs are characteristic features of giant cell tumor of the tendon sheath and giant cell tumor of soft tissue but they have also been described in numerous other cutaneous conditions. The diagnostic and prognostic significance of the presence of OLGCs is unknown. Here, we summarize the clinical entities that can exhibit these cells to avoid a histological overlap, affecting diagnosis and management.
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http://dx.doi.org/10.1097/DAD.0000000000001769DOI Listing
March 2021

Plasmacytoid dendritic cell and type I interferons as possible explanation for clearance of longstanding warts during COVID-19 in a transplant patient, reply to Erkayman et al.

Transpl Infect Dis 2021 08 26;23(4):e13585. Epub 2021 Feb 26.

Department of Dermatology, American University of Beirut Medical Center, Beirut, Lebanon.

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http://dx.doi.org/10.1111/tid.13585DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7995015PMC
August 2021

Reply to ''Coexistence of frontal fibrosing alopecia and alopecia areata: 3 new cases and review of the literature'': plasmacytoid dendritic cell as possible link.

Int J Dermatol 2021 06 16;60(6):e234-e235. Epub 2021 Feb 16.

Department of Dermatology, American University of Beirut Medical Center, Beirut, Lebanon.

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http://dx.doi.org/10.1111/ijd.15469DOI Listing
June 2021

Diagnostic utility of plasmacytoid dendritic cells in dermatopathology.

Indian J Dermatol Venereol Leprol 2021 Jan-Feb;87(1):3-13

Department of Dermatology, American University of Beirut Medical Center, Beirut, Lebanon.

Differentiating cutaneous diseases that mimic each other clinically and histopathologically can at times be a challenging task for the dermatopathologist. At the same time, differentiation of entities with overlapping features may be crucial for patient management. Although not seen in normal skin, plasmacytoid dendritic cells usually infiltrate the skin in several infectious, inflammatory/autoimmune and neoplastic entities. Plasmacytoid dendritic cells can be identified in tissue using specific markers such as CD123 and/or blood-derived dendritic cell antigen-2. Plasmacytoid dendritic cells are the most potent producers of type I interferons and their activity may therefore be assessed indirectly in tissue using human myxovirus resistance protein A, a surrogate marker for type I interferon production. In recent years, accumulating evidence has established the utility of evaluating for specific plasmacytoid dendritic cell-related parameters (plasmacytoid dendritic cell content, distribution and clustering and/ or human myxovirus resistance protein A expression) as a diagnostic tool in differentiating cutaneous diseases with overlapping features such as the alopecias, lupus and its mimics, and neoplastic entities. In this review, we provide an update on the current evidence on this topic and on the contexts where this can be a useful adjunct to reach the histopathological diagnosis.
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http://dx.doi.org/10.25259/IJDVL_638_19DOI Listing
August 2019

Investigating the presence of neutrophil extracellular traps in septal and lobular cutaneous panniculitides.

Int J Dermatol 2021 Jun 13;60(6):724-729. Epub 2021 Feb 13.

Department of Dermatology, American University of Beirut Medical Center, Beirut, Lebanon.

Background: Panniculitides are a heterogeneous group of inflammatory dermatoses involving the subcutaneous fatty tissue. Histologically, they are classified into septal and lobular panniculitis, according to the predominant localization of the inflammatory infiltrate. Neutrophils are frequently found in panniculitis, mainly at the early stages. Here, we investigated whether neutrophils contribute to various types of cutaneous panniculitis by releasing neutrophil extracellular traps (NETs).

Materials And Methods: Formalin-fixed paraffin-embedded skin biopsies from 25 patients with panniculitis were included in the study. Our cohort was divided into n = 10 erythema nodosum (septal panniculitis) and n = 15 lobular panniculitis, including n = 7 lupus panniculitis, n = 1 pancreatic panniculitis, n = 1 Weber-Christian disease, n = 1 deep fungal infection, n = 2 lipodermatosclerosis, and three cases did not have an identified etiology. The presence of neutrophils and NETs was assessed by double immunofluorescence using antibodies against elastase, a neutrophilic marker, and citrullinated histone 3, a marker of NETs.

Results: The mean percentages (±SEM) of elastase-positive neutrophils showing NETs were 44% ± 3% in erythema nodosum and 43% ± 7% in lobular panniculitis. The difference was not statistically significant and reflects the implication of NETs not only in severe scarring lobular panniculitis but also in benign non-scarring self-remitting reactive inflammation such as erythema nodosum. In tissues, NETs were located in the interlobular septa in erythema nodosum and in the inflamed fat lobules in lobular panniculitis.

Conclusions: NETs are massively present in septal and lobular subtypes of panniculitides, suggesting their involvement in tissue damage.
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http://dx.doi.org/10.1111/ijd.15450DOI Listing
June 2021

Generalized granuloma annulare associated with interstitial lung disease: Good response to doxycycline.

Dermatol Ther 2021 03 17;34(2):e14864. Epub 2021 Feb 17.

American University of Beirut Medical Center, Beirut, Lebanon.

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http://dx.doi.org/10.1111/dth.14864DOI Listing
March 2021

Reply to "Elastin fiber but not collagen fiber is decreased dramatically in the dermis of vitiligo patients": possible mechanisms of decreased elastin fibers.

Int J Dermatol 2021 03 7;60(3):e80. Epub 2021 Jan 7.

Department of Dermatology, American University of Beirut Medical Center, Beirut, Lebanon.

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http://dx.doi.org/10.1111/ijd.15412DOI Listing
March 2021

Dowling-Degos disease: a review.

Int J Dermatol 2021 Aug 23;60(8):944-950. Epub 2020 Dec 23.

Department of Dermatology, American University of Beirut, Beirut, Lebanon.

Dowling-Degos disease is a rare autosomal dominant genodermatosis. It is characterized by acquired reticulate hyperpigmentation over the flexures, comedone-like follicular papules, and pitted perioral scars that usually develop during adulthood. Mutations in genes affecting melanosome transfer, and melanocyte and keratinocyte differentiation have been implicated in the pathogenesis of this disease. These genes include KRT5, POFUT1, POGLUT1 and, most recently, PSENEN. Dowling-Degos disease can be found in isolation or with other associated findings, most notably hidradenitis suppurativa. This condition belongs to a spectrum of conditions that all result in reticulate hyperpigmentation that at times are hard to distinguish from each other. The most closely linked entity is Galli-Galli, which is clinically indistinguishable from Dowling-Degos disease and can only be distinguished by the presence of acantholysis on microscopy. Unfortunately, Dowling-Degos disease is generally progressive and recalcitrant to treatment.
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http://dx.doi.org/10.1111/ijd.15385DOI Listing
August 2021

Reply to: "The histopathological spectrum of Melkersson-Rosenthal syndrome: Analysis of 47 cases".

J Cutan Pathol 2021 04 18;48(4):604-605. Epub 2020 Dec 18.

Department of Dermatology, American University of Beirut Medical Center, Beirut, Lebanon.

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http://dx.doi.org/10.1111/cup.13935DOI Listing
April 2021

Neuroendocrine Differentiation of Skin Tumors: A Comprehensive Review.

Am J Dermatopathol 2020 Dec;42(12):899-910

Professor, Dermatopathology Section, Department of Dermatology, Boston University School of Medicine, Boston, MA.

Neuroendocrine differentiation is characterized by endocrine and neuronal features with prominent dense secretory granules and neuropeptides. Neuroendocrine differentiation of skin tumors is of unknown clinical significance. Nonetheless, the acknowledgment of this line of differentiation is important to prevent diagnostic pitfalls and subsequent inappropriate management. This review aims at summarizing the skin neoplasms that can express neuroendocrine markers.
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http://dx.doi.org/10.1097/DAD.0000000000001664DOI Listing
December 2020

Asymptomatic growth overlying a scar in a child.

Pediatr Dermatol 2020 Nov;37(6):e93-e94

Department of Dermatology, American University of Beirut Medical Center, Beirut, Lebanon.

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http://dx.doi.org/10.1111/pde.14396DOI Listing
November 2020

Comparative characterization of sun exposed and sun protected skin-derived mesenchymal-like stem cells in variegate porphyria and healthy individuals.

Photodermatol Photoimmunol Photomed 2021 May 11;37(3):202-213. Epub 2020 Dec 11.

Faculty of Medicine, Dermatology Department, American University of Beirut, Beirut, Lebanon.

Background And Purpose: We hypothesized that upon sun exposure, a sub-population of primary skin-derived mesenchymal-like cells is deleteriously affected and thus contribute to the chronic inflammatory state in autosomal recessive variegate porphyria patients. The aim of this study was to isolate and characterize the mesenchymal-like stem cells from different areas of the skin in a porphyria patient (sun exposed, SE, and sun protected, SP) and to compare them with cells from a healthy individual.

Methods: The proliferation rate and the migration ability of SE and SP cells were evaluated in the presence of an antioxidant compound, N-acetylcysteine. A co-culture of SE-damaged cells with the conditioned medium from the enriched mesenchymal cell-like SP population was performed in order to regenerate the dermal injured tissue after sun exposure in patients.

Results: Results showed that the percentage of CD105 cells varies between 3.9% in SP and 5% in SE of the healthy individual and between 3.6% and 1.4% in SP and SE in the porphyria patient, respectively. The osteogenic differentiation potential was lower in the porphyria patient when compared to the control. Furthermore, the expression of stem cell markers was more pronounced in SE than in SP cells of both control and porphyria. The use of N-acetyl cysteine did not show any beneficial effects on porphyria SE cells. Treatment with SP-conditioned medium slightly increased the expression of stem cell markers in SE of porphyria patient.

Conclusion: In conclusion, the pool of mesenchymal stem-like SE cells is affected in variegate porphyria patient along with modification of their self-renewal and differentiation properties.
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http://dx.doi.org/10.1111/phpp.12635DOI Listing
May 2021

Elastophagocytosis in Juvenile Xanthogranuloma: A Case Report.

Am J Dermatopathol 2021 Jun;43(6):468-469

Department of Dermatology, Lebanese American University Medical Center-Rizk Hospital, Beirut, Lebanon.

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http://dx.doi.org/10.1097/DAD.0000000000001848DOI Listing
June 2021

Integrative Transcriptome Analyses Empower the Anti-COVID-19 Drug Arsenal.

iScience 2020 Nov 19;23(11):101697. Epub 2020 Oct 19.

Department of Pharmacology and Physiology, Université de Montréal, Montreal, QC, Canada.

The beginning of the 21st century has been marked by three distinct waves of zoonotic coronavirus outbreaks into the human population. The COVID-19 (coronavirus disease 2019) pandemic is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and emerged as a global threat endangering the livelihoods of millions worldwide. Currently, and despite collaborative efforts, diverse therapeutic strategies from ongoing clinical trials are still debated. To address the need for such an immediate call of action, we leveraged the largest dataset of drug-induced transcriptomic perturbations, public SARS-CoV-2 transcriptomic datasets, and expression profiles from normal lung transcriptomes. Most importantly, our unbiased systems biology approach prioritized more than 50 repurposable drug candidates (e.g., corticosteroids, Janus kinase and Bruton kinase inhibitors). Further clinical investigation of these FDA-approved candidates as monotherapy or in combination with an antiviral regimen (e.g., remdesivir) could lead to promising outcomes in patients with COVID-19.
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http://dx.doi.org/10.1016/j.isci.2020.101697DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7571421PMC
November 2020

A rapidly growing crateriform nodule on the nose.

Indian J Dermatol Venereol Leprol 2020 Nov-Dec;86(6):752

Department of Dermatology, American University of Beirut Medical Center, Beirut, Lebanon.

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http://dx.doi.org/10.4103/ijdvl.IJDVL_422_20DOI Listing
September 2021

Follicular mucinosis: a review.

Int J Dermatol 2021 Feb 2;60(2):159-165. Epub 2020 Sep 2.

Dermatology Department, American University of Beirut Medical Center, Beirut, Lebanon.

Follicular mucinosis (FM) is an epithelial reaction pattern characterized by follicular mucin accumulation. It has been described in association with various inflammatory and neoplastic cutaneous disorders. FM is generally divided into a primary benign idiopathic form and a secondary form usually occurring in association with cutaneous lymphomas (especially mycosis fungoides), among other entities. Distinction between the two forms can be challenging as they share many overlapping features and the lack of a single diagnostic tool to differentiate between the two. Making the distinction may require evaluating and correlating the clinical, histologic, immunohistochemical, and molecular studies together. Long-term clinical follow-up also remains very important. In this review, we describe the different entities associated with FM, its pathogenesis, and possible therapeutic options.
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http://dx.doi.org/10.1111/ijd.15165DOI Listing
February 2021
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