Dr Osmar N Silva, PhD - Universidade Católica Dom Bosco - Postdoctoral Researcher

Dr Osmar N Silva

PhD

Universidade Católica Dom Bosco

Postdoctoral Researcher

Campo Grande, Mato Grosso do Sul | Brazil

Main Specialties: Biotechnology

ORCID logohttps://orcid.org/0000-0003-2148-131X

Dr Osmar N Silva, PhD - Universidade Católica Dom Bosco - Postdoctoral Researcher

Dr Osmar N Silva

PhD

Introduction

Postdoctoral Researcher at S-INOVA group with experience in the use of animals in experimental infections and applied immunology. Expert in infections with Escherichia coli, Klebsiella enterica and Staphylococcus aureus. I study the mechanism of action of host defense peptides (HDPs) and their role as modulators of innate immunity, the development of new therapies based on the antibiotic and immunomodulatory activity of HDPs.

Primary Affiliation: Universidade Católica Dom Bosco - Campo Grande, Mato Grosso do Sul , Brazil

Specialties:

Research Interests:

Education

Mar 2009 - May 2015
Universidade Federal de Juiz de Fora
PhD
Ciências Biológicas
Mar 2009 - Feb 2011
Universidade Federal de Juiz de Fora
Master
Ciências Biológicas

Experience

Jun 2016
Universidade Católica Dom Bosco
Postdoctoral Researcher
Biotecnologia

Publications

48Publications

348Reads

1Profile Views

67PubMed Central Citations

Clavanin A-bioconjugated FeO/Silane core-shell nanoparticles for thermal ablation of bacterial biofilms.

Colloids Surf B Biointerfaces 2018 09 27;169:72-81. Epub 2018 Apr 27.

Programa de Pós-Graduação em Inovação Terapêutica, Universidade Federal de Pernambuco, 50670-901 Recife, PE, Brazil; Departamento de Bioquímica, Universidade Federal de Pernambuco, 50670-901 Recife, PE, Brazil. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.colsurfb.2018.04.055DOI Listing
September 2018
5 Reads
4.152 Impact Factor

Host-defense peptides and their potential use as biomarkers in human diseases.

Drug Discov Today 2018 09 24;23(9):1666-1671. Epub 2018 May 24.

S-Inova Biotech, Programa de Pós-Graduação em Biotecnologia, Universidade Católica Dom Bosco, Campo Grande, MS, Brazil; Centro de Análises Proteômicas e Bioquímicas, Universidade Católica de Brasília, Brasília, DF, Brazil; Departamento de Patologia Molecular, Universidade de Brasília, Brasília, DF, Brazil. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.drudis.2018.05.024DOI Listing
September 2018
6 Reads
6.691 Impact Factor

Recombinant Trypsin Inhibitor (ILTI) Production in Confirms Its Potential Anti-Biofilm Effect and Reveals an Anti-Tumoral Activity.

Microorganisms 2018 04 28;6(2). Epub 2018 Apr 28.

Grupo de Engenharia de Biocatalizadores, Instituto de Ciências Biológicas, Universidade de Brasília, CEP 70.790-900 Brasília-DF, Brazil.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/microorganisms6020037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6027459PMC
April 2018
3 Reads

In vivo efficacy of anuran trypsin inhibitory peptides against staphylococcal skin infection and the impact of peptide cyclization.

Malik U, Silva ON, Fensterseifer IC, Chan LY, Clark RJ, Franco OL, Daly NL, Craik DJ, Antimicrobial agents and chemotherapy, 2015, vol. 59, no. 4, pp. 2113-2121

http://europepmc.org/abstract/med/25624332

View Article
May 2015
4 Reads

Clavanin A improves outcome of complications from different bacterial infections.

Silva ON, Fensterseifer IC, Rodrigues EA, Holanda HH, Novaes NR, Cunha JP, Rezende TM, Magalhães KG, Moreno SE, Jerônimo MS, Bocca AL, Franco OL, Antimicrobial agents and chemotherapy, 2015, vol. 59, no. 3, pp. 1620-1626

http://europepmc.org/abstract/med/25547358

View Article
March 2015
91 Reads

Effects of cyclotides against cutaneous infections caused by Staphylococcus aureus.

Fensterseifer IC, Silva ON, Malik U, Ravipati AS, Novaes NR, Miranda PR, Rodrigues EA, Moreno SE, Craik DJ, Franco OL, Peptides, 2015, vol. 63, pp. 38-42

http://europepmc.org/abstract/med/25451333

View Article
January 2015
5 Reads

Investigating specific bacterial resistance to AMPs by using a magainin I-resistant Escherichia coli model.

de Almeida KC, Lima TB, Motta DO, Silva ON, Magalhães BS, Dias SC, Franco OL, The Journal of antibiotics, 2014, vol. 67, no. 10, pp. 681-687

http://europepmc.org/abstract/med/24802209

View Article
October 2014
5 Reads

Investigating specific bacterial resistance to AMPs by using a magainin I-resistant Escherichia coli model.

J Antibiot (Tokyo) 2014 Oct 7;67(10):681-7. Epub 2014 May 7.

1] Centro de Análises Proteômicas e Bioquímicas, Pós-Graduação em Ciências Genômicas e Biotecnologia, Universidade Católica de Brasília, Brasília, Brazil [2] Pós-Graduação em Patologia Molecular, Universidade de Brasília, Brasília, Brazil.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ja.2014.48DOI Listing
October 2014
43 Reads
3 Citations
2.041 Impact Factor

Characterization and pharmacological properties of a novel multifunctional Kunitz inhibitor from Erythrina velutina seeds.

PLoS One 2013 28;8(5):e63571. Epub 2013 May 28.

Laboratório de Química e Função de Proteínas Bioativas, Departamento de Bioquímica, Centro de Biociências, Universidade Federal do Rio Grande do Norte, Natal, RN, Brasil.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0063571PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3666885PMC
February 2014
37 Reads
7 Citations
3.234 Impact Factor

Dentistry proteomics: from laboratory development to clinical practice.

Rezende TM, Lima SM, Petriz BA, Silva ON, Freire MS, Franco OL, Journal of cellular physiology, 2013, vol. 228, no. 12, pp. 2271-2284

http://europepmc.org/abstract/med/24037769

View Article
2013
5 Reads

Dentistry proteomics: from laboratory development to clinical practice.

J Cell Physiol 2013 Dec;228(12):2271-84

Centro de Análises Proteômicas e Bioquímicas, Programa de Pós-Graduação em Ciências Genômicas e Biotecnologia, Universidade Católica de Brasília, Brasília, Distrito Federal, Brazil; Curso de Odontologia, Universidade Católica de Brasília, Brasília, Distrito Federal, Brazil.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jcp.24410DOI Listing
December 2013
39 Reads
2 Citations
3.840 Impact Factor

Structural and functional characterization of a multifunctional alanine-rich peptide analogue from Pleuronectes americanus.

PLoS One 2012 8;7(10):e47047. Epub 2012 Oct 8.

Centro de Análises Proteômicas e Bioquímicas-Programa de Pós-Graduação em Ciências Genômicas e Biotecnologia, Universidade Católica de Brasília, Distrito Federal, Brazil.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0047047PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3466273PMC
May 2013
32 Reads
4 Citations
3.234 Impact Factor

In vivo antimicrobial evaluation of an alanine-rich peptide derived from Pleuronectes americanus.

Peptides 2013 Apr 13;42:144-8. Epub 2013 Feb 13.

Centro de Análises Proteômicas e Bioquímicas, Pós-Graduação em Ciências Genômicas e Biotecnologia, Universidade Católica de Brasília, Brasília, DF, Brazil.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.peptides.2013.02.001DOI Listing
April 2013
4 Reads
3 Citations
2.620 Impact Factor

Effects of acute exercise over heart proteome from monogenic obese (ob/ob) mice.

J Cell Physiol 2013 Apr;228(4):824-34

Centro de Análises Proteômicas e Bioquímicas Programa de Pós-Graduação em Ciências Genômicas e Biotecnologia, Universidade Católica de Brasília, Brasília-DF, Brazil.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jcp.24231DOI Listing
April 2013
25 Reads
4 Citations
3.840 Impact Factor

Cn-AMP1: a new promiscuous peptide with potential for microbial infections treatment.

Biopolymers 2012 ;98(4):322-31

Centro de Análises Proteômicas e Bioquímicas, Programa de Pós-Graduação em Ciências Genômicas e Biotecnologia, Universidade Católica de Brasília, Brasília-DF, Brazil.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/bip.22071DOI Listing
January 2013
33 Reads
11 Citations
2.385 Impact Factor

Exploring the pharmacological potential of promiscuous host-defense peptides: from natural screenings to biotechnological applications.

Front Microbiol 2011 22;2:232. Epub 2011 Nov 22.

Programa de Pós-Graduação em Ciências Genômicas e Biotecnologia, Centro de Análises Protômicas e Bioquímicas, Universidade Católica de Brasília Brasília, Brazil.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fmicb.2011.00232DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3222093PMC
October 2012
28 Reads
8 Citations
3.941 Impact Factor

Functional characterization of a synthetic hydrophilic antifungal peptide derived from the marine snail Cenchritis muricatus.

Biochimie 2012 Apr 24;94(4):968-74. Epub 2011 Dec 24.

Centro de Estudios de Proteínas, Facultad de Biología, Universidad de La Habana, Calle 25 entre J e I, Vedado, Municipio Plaza, La Habana 10400, Cuba.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.biochi.2011.12.016DOI Listing
April 2012
14 Reads
9 Citations
2.963 Impact Factor

A Kunitz proteinase inhibitor from corms of Xanthosoma blandum with bactericidal activity.

J Nat Prod 2011 May 26;74(5):969-75. Epub 2011 Apr 26.

Centro de Análises Proteômicas e Bioquímicas, Programa de Pós-Graduação em Ciências Genômicas e Biotecnologia, Universidade Católica de Brasília, Brasília, Brazil.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/np200312rDOI Listing
May 2011
7 Reads
4 Citations
3.800 Impact Factor

Top co-authors

Octavio L Franco
Octavio L Franco

Centro de Análises Proteômicas e Bioquímicas

9
Ludovico Migliolo
Ludovico Migliolo

Centro de Biociências

8
Simoni C Dias
Simoni C Dias

Centro de Análises Proteômicas e Bioquímicas

6
Octavio L Franco
Octavio L Franco

Centro de Análises Proteômicas e Bioquímicas

5
Maysa P Costa
Maysa P Costa

Centro de Estudios de Proteínas

3
William F Porto
William F Porto

Centro de Análises Proteômicas e Bioquímicas

3
Carolina R Costa
Carolina R Costa

Institute of Tropical Pathology and Public Health

3
Beatriz S Magalhaes
Beatriz S Magalhaes

Pós-Graduação em Ciências Genômicas e Biotecnologia

2