Oscar Zaragoza

Oscar Zaragoza

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Oscar Zaragoza

Oscar Zaragoza

Publications by authors named "Oscar Zaragoza"

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72Publications

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Cryptococcal pathogenic mechanisms: a dangerous trip from the environment to the brain.

Mem Inst Oswaldo Cruz 2018 16;113(7):e180057. Epub 2018 Apr 16.

Department of Medicine, Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, USA.

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May 2018

Cryptococcus neoformans can form titan-like cells in vitro in response to multiple signals.

PLoS Pathog 2018 05 18;14(5):e1007007. Epub 2018 May 18.

Mycology Reference Laboratory, National Centre for Microbiology, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain.

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May 2018

Capsule Enlargement in Is Dependent on Mitochondrial Activity.

Front Microbiol 2017 31;8:1423. Epub 2017 Jul 31.

Mycology Reference Laboratory, National Centre for Microbiology, Instituto de Salud Carlos IIIMadrid, Spain.

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July 2017

Fungemia due to rare opportunistic yeasts: data from a population-based surveillance in Spain.

Med Mycol 2017 Feb 4;55(2):125-136. Epub 2016 Aug 4.

Unit of Infectious Diseases, Hospital Universitario "12 de Octubre," Instituto de Investigación Hospital "12 de Octubre" (i+12), Universidad Complutense, Madrid, Spain.

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February 2017

New Panfungal Real-Time PCR Assay for Diagnosis of Invasive Fungal Infections.

J Clin Microbiol 2016 12 14;54(12):2910-2918. Epub 2016 Sep 14.

Mycology Department, National Centre for Microbiology, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain

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December 2016

Role of catalase overproduction in drug resistance and virulence in Candida albicans.

Future Microbiol 2016 Oct 3. Epub 2016 Oct 3.

Departamento de Microbiología II, Facultad de Farmacia, Universidad Complutense de Madrid, Plaza de Ramón y Cajal s/n, E-28040 Madrid, Spain.

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October 2016

Fungal morphogenetic changes inside the mammalian host.

Semin Cell Dev Biol 2016 09 19;57:100-109. Epub 2016 Apr 19.

Mycology Reference Laboratory, National Centre for Microbiology, Instituto de Salud Carlos III, Carretera Majadahonda-Pozuelo Km2, Majadahonda 28220, Madrid, Spain. Electronic address:

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September 2016

Erratum for Marcos-Zambrano et al., Comparison between the EUCAST Procedure and the Etest for Determination of the Susceptibility of Candida Species Isolates to Micafungin.

Antimicrob Agents Chemother 2016 07 20;60(7):4429. Epub 2016 Jun 20.

Clinical Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Marañón, Madrid, Spain Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain CIBER Enfermedades Respiratorias-CIBERES (CD06/06/0058), Palma de Mallorca, Spain Medicine Department, School of Medicine, Universidad Complutense de Madrid, Madrid, Spain.

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July 2016

Biofilm Production and Antibiofilm Activity of Echinocandins and Liposomal Amphotericin B in Echinocandin-Resistant Yeast Species.

Antimicrob Agents Chemother 2016 06 23;60(6):3579-86. Epub 2016 May 23.

Clinical Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Marañón, Madrid, Spain Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain CIBER Enfermedades Respiratorias-CIBERES (CB06/06/0058), Madrid, Spain Medicine Department, School of Medicine, Universidad Complutense de Madrid, Madrid, Spain

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June 2016

Corrigendum: Impact of Resistance to Fluconazole on Virulence and Morphological Aspects of Cryptococcus neoformans and Cryptococcus gattii Isolates.

Front Microbiol 2016 22;7:537. Epub 2016 Apr 22.

Laboratório de Micologia Clínica e Núcleo de Proteômica, Faculdade de Ciências Farmacêuticas, Universidade Estadual Paulista Júlio Mesquita Filho Araraquara, Brazil.

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May 2016

Cell Wall Changes in Amphotericin B-Resistant Strains from Candida tropicalis and Relationship with the Immune Responses Elicited by the Host.

Antimicrob Agents Chemother 2016 Apr 25;60(4):2326-35. Epub 2016 Mar 25.

National Centre for Microbiology, Mycology Reference Laboratory, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain

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April 2016

Cryptococcus neoformans induces antimicrobial responses and behaves as a facultative intracellular pathogen in the non mammalian model Galleria mellonella.

Virulence 2015 ;6(1):66-74

a Mycology Reference Laboratory ; National Center for Microbiology ; Instituto de Salud Carlos III ; Carretera Majadahonda-Pozuelo, Km2 ; Majadahonda , 28220 , Madrid , Spain.

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February 2016

Impact of Resistance to Fluconazole on Virulence and Morphological Aspects of Cryptococcus neoformans and Cryptococcus gattii Isolates.

Front Microbiol 2016 16;7:153. Epub 2016 Feb 16.

Faculdade de Ciências Farmacêuticas, UNESP - Universidade Estadual Paulista, Campus Araraquara, Departamento de Análises Clíncas São Paulo, Brazil.

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February 2016

The formation of titan cells in Cryptococcus neoformans depends on the mouse strain and correlates with induction of Th2-type responses.

Cell Microbiol 2016 Jan 6;18(1):111-24. Epub 2015 Sep 6.

Mycology Reference Laboratory, National Centre for Microbiology, Instituto de Salud Carlos III, Carretera Majadahonda-Pozuelo Km2, Majadahonda, Madrid, 28220, Spain.

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January 2016

Role of Cln1 during melanization of Cryptococcus neoformans.

Front Microbiol 2015 12;6:798. Epub 2015 Aug 12.

Mycology Reference Laboratory, National Centre for Microbiology, Instituto de Salud Carlos III Majadahonda, Spain.

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August 2015

Distinct and redundant roles of exonucleases in Cryptococcus neoformans: implications for virulence and mating.

Fungal Genet Biol 2014 Dec 28;73:20-8. Epub 2014 Sep 28.

Institut Pasteur, Unité Biologie et Pathogénicité Fongiques - INRA USC2019, 75015 Paris, France. Electronic address:

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December 2014

Molecular identification and antifungal susceptibility of yeast isolates causing fungemia collected in a population-based study in Spain in 2010 and 2011.

Antimicrob Agents Chemother 2014 23;58(3):1529-37. Epub 2013 Dec 23.

Clinical Microbiology and Infectious Diseases Department, Hospital General Universitario Gregorio Marañón, Universidad Complutense de Madrid, Madrid, Spain.

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October 2014

Paradoxical growth of Candida albicans in the presence of caspofungin is associated with multiple cell wall rearrangements and decreased virulence.

Antimicrob Agents Chemother 2014 2;58(2):1071-83. Epub 2013 Dec 2.

Mycology Reference Laboratory, National Center for Microbiology, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain.

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September 2014

Capsule growth in Cryptococcus neoformans is coordinated with cell cycle progression.

MBio 2014 Jun 17;5(3):e00945-14. Epub 2014 Jun 17.

Mycology Reference Laboratory, National Centre for Microbiology, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain

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June 2014

Expanding the use of alternative models to investigate novel aspects of immunity to microbial pathogens.

Virulence 2014 May 9;5(4):454-6. Epub 2014 Apr 9.

Mycology Reference Laboratory; National Centre for Microbiology; Instituto de Salud Carlos III; Madrid, Spain.

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May 2014

Comparison between the EUCAST procedure and the Etest for determination of the susceptibility of Candida species isolates to micafungin.

Antimicrob Agents Chemother 2013 Nov 26;57(11):5767-70. Epub 2013 Aug 26.

Clinical Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Marañón, Madrid, Spain.

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November 2013

Titan cells in Cryptococcus neoformans: cells with a giant impact.

Curr Opin Microbiol 2013 Aug 12;16(4):409-13. Epub 2013 Apr 12.

National Centre for Microbiology, Instituto de Salud Carlos III, Carretera Majadahonda-Pozuelo, Km 2, Majadahonda 28220, Madrid, Spain.

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August 2013

Galleria mellonella as a model host to study Paracoccidioides lutzii and Histoplasma capsulatum.

Virulence 2013 Feb 9;4(2):139-46. Epub 2013 Jan 9.

Institute of Biomedical Science, Department of Microbiology, University of São Paulo, São Paulo, Brazil.

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February 2013

It only takes one to do many jobs: Amphotericin B as antifungal and immunomodulatory drug.

Front Microbiol 2012 8;3:286. Epub 2012 Aug 8.

Mycology Reference Laboratory, National Centre for Microbiology, Instituto de Salud Carlos III Majadahonda, Madrid, Spain ; Group of Investigative Dermatology, University of Antioquia Medellín, Colombia.

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October 2012

Catch me if you can: phagocytosis and killing avoidance by Cryptococcus neoformans.

FEMS Immunol Med Microbiol 2012 Mar;64(2):147-61

Mycology Reference Laboratory, National Centre for Microbiology, Instituto de Salud Carlos III, Madrid, Spain.

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March 2012

Cryptococcus neoformans capsular enlargement and cellular gigantism during Galleria mellonella infection.

PLoS One 2011 7;6(9):e24485. Epub 2011 Sep 7.

Mycology Reference Laboratory, National Centre for Microbiology, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain.

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February 2012

Multiple Disguises for the Same Party: The Concepts of Morphogenesis and Phenotypic Variations in Cryptococcus neoformans.

Authors:
Oscar Zaragoza

Front Microbiol 2011 6;2:181. Epub 2011 Sep 6.

Mycology Reference Laboratory, National Centre for Microbiology, Instituto de Salud Carlos III Madrid, Spain.

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November 2011

High-resolution melting analysis for identification of the Cryptococcus neoformans-Cryptococcus gattii complex.

J Clin Microbiol 2011 Oct 10;49(10):3663-6. Epub 2011 Aug 10.

Servicio de Micología, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Ctra Majadahonda-Pozuelo, Km 2, 28220 Majadahonda (Madrid), Spain.

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October 2011

Amphotericin B induces trehalose synthesis and simultaneously activates an antioxidant enzymatic response in Candida albicans.

Biochim Biophys Acta 2011 Aug 5;1810(8):777-83. Epub 2011 May 5.

Área de Microbiología, Facultad de Biología, Universidad de Murcia, E-30071, Murcia, Spain.

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August 2011

The interaction between Candida krusei and murine macrophages results in multiple outcomes, including intracellular survival and escape from killing.

Infect Immun 2011 Jun 21;79(6):2136-44. Epub 2011 Mar 21.

Mycology Reference Laboratory, National Centre for Microbiology, Instituto de Salud Carlos III, Crta. Majadahonda-Pozuelo, Km2, Majadahonda 28220, Madrid, Spain.

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June 2011

Amphotericin B mediates killing in Cryptococcus neoformans through the induction of a strong oxidative burst.

Microbes Infect 2011 May 21;13(5):457-67. Epub 2011 Feb 21.

Mycology Reference Laboratory, National Centre for Microbiology, Instituto de Salud Carlos III, Crta Majadahonda-Pozuelo Km 2, Majadahonda 28220, Madrid, Spain.

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May 2011

Process analysis of variables for standardization of antifungal susceptibility testing of nonfermentative yeasts.

Antimicrob Agents Chemother 2011 Apr 18;55(4):1563-70. Epub 2011 Jan 18.

Servicio de Micología, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Carretera Majadahonda-Pozuelo, km 2, Majadahonda 28220, Madrid, Spain.

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April 2011

Fungal cell gigantism during mammalian infection.

PLoS Pathog 2010 Jun 17;6(6):e1000945. Epub 2010 Jun 17.

Servicio de Micología, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain.

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June 2010

The capsule of the fungal pathogen Cryptococcus neoformans.

Adv Appl Microbiol 2009 ;68:133-216

Servicio de Micología, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Crta Majadahonda-Pozuelo, Km2, Majadahonda 28220, Madrid, Spain.

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July 2009

Pharmacotherapy of yeast infections.

Expert Opin Pharmacother 2008 Nov;9(16):2801-16

Instituto de Salud Carlos III, Servicio de Micología, Centro Nacional de Microbiología, Carretera Majadahonda-Pozuelo, Km2, Majadahonda 28220, Madrid, Spain.

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November 2008

Update on the epidemiology and diagnosis of invasive fungal infection.

Int J Antimicrob Agents 2008 Nov;32 Suppl 2:S143-7

Servicio de Micología, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain.

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November 2008

Capsule enlargement in Cryptococcus neoformans confers resistance to oxidative stress suggesting a mechanism for intracellular survival.

Cell Microbiol 2008 Oct 28;10(10):2043-57. Epub 2008 Jun 28.

Servicio de Micología, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Carretera Majadahonda-Pozuelo, Km 2, Majadahonda, 28220, Madrid, Spain.

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October 2008

Finite-element model of interaction between fungal polysaccharide and monoclonal antibody in the capsule of Cryptococcus neoformans.

J Phys Chem B 2008 Jul 28;112(29):8514-22. Epub 2008 Jun 28.

Department of Biological and Environmental Engineering, Cornell University, Ithaca, New York 14853, USA.

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July 2008

The relative susceptibility of mouse strains to pulmonary Cryptococcus neoformans infection is associated with pleiotropic differences in the immune response.

Infect Immun 2007 Jun 19;75(6):2729-39. Epub 2007 Mar 19.

Departments of Microbiology and Immunology and Medicine, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA.

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June 2007

The volume and hydration of the Cryptococcus neoformans polysaccharide capsule.

Fungal Genet Biol 2007 Mar 11;44(3):180-6. Epub 2006 Sep 11.

Albert Einstein College of Medicine, Department of Microbiology and Immunology, Bronx, NY 10461, USA.

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March 2007

Radial mass density, charge, and epitope distribution in the Cryptococcus neoformans capsule.

Eukaryot Cell 2007 Jan 17;6(1):95-109. Epub 2006 Nov 17.

Department of Microbiology and Immunology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA.

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January 2007

Vesicular polysaccharide export in Cryptococcus neoformans is a eukaryotic solution to the problem of fungal trans-cell wall transport.

Eukaryot Cell 2007 Jan 17;6(1):48-59. Epub 2006 Nov 17.

Laboratório de Estudos Integrados em Bioquímica Microbiana, Instituto de Microbiologia Professor Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941590, Brazil.

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January 2007

Monoclonal antibodies can affect complement deposition on the capsule of the pathogenic fungus Cryptococcus neoformans by both classical pathway activation and steric hindrance.

Cell Microbiol 2006 Dec 4;8(12):1862-76. Epub 2006 Jul 4.

Albert Einstein College of Medicine, Departments of Microbiology and Immunology, 1300 Morris Park Avenue, Bronx, NY 10461, USA.

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December 2006

Characterization of a flocculation-like phenotype in Cryptococcus neoformans and its effects on pathogenesis.

Cell Microbiol 2006 Nov 7;8(11):1730-9. Epub 2006 Jun 7.

Department of Medicine, Department of Microbiology and Immunology, Albert-Einstein College of Medicine, Ullmann Building 1223, 1300 Morris Park Ave, Bronx, NY 10461, USA.

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November 2006

The capsular dynamics of Cryptococcus neoformans.

Trends Microbiol 2006 Nov 25;14(11):497-505. Epub 2006 Sep 25.

Department of Medicine, Division of Infectious Disease, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

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November 2006

Efficacy of voriconazole in experimental Cryptococcus neoformans infection.

Mycopathologia 2006 Aug;162(2):111-4

Department of Microbiology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

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August 2006

Equatorial ring-like channels in the Cryptococcus neoformans polysaccharide capsule.

FEMS Yeast Res 2006 Jun;6(4):662-6

Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

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June 2006

Structural and functional characterization of glycosylation in an immunoglobulin G1 to Cryptococcus neoformans glucuronoxylomannan.

Mol Immunol 2006 Mar 19;43(7):987-98. Epub 2005 Jul 19.

Laboratory for Macromolecular Analysis and Proteomics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA.

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March 2006

The polysaccharide capsule of the pathogenic fungus Cryptococcus neoformans enlarges by distal growth and is rearranged during budding.

Mol Microbiol 2006 Jan;59(1):67-83

Department of Microbiology and Immunology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA.

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January 2006

Comparative analysis of Cryptococcus neoformans acid-resistant particles generated from pigmented cells grown in different laccase substrates.

Fungal Genet Biol 2005 Dec 11;42(12):989-98. Epub 2005 Nov 11.

Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

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December 2005

Effect of amphotericin B on capsule and cell size in Cryptococcus neoformans during murine infection.

Antimicrob Agents Chemother 2005 Oct;49(10):4358-61

Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York 10461, USA.

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October 2005

Antibody-mediated protection against Cryptococcus neoformans pulmonary infection is dependent on B cells.

Infect Immun 2005 Feb;73(2):1141-50

Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA.

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February 2005

Antibodies produced in response to Cryptococcus neoformans pulmonary infection in mice have characteristics of nonprotective antibodies.

Infect Immun 2004 Jul;72(7):4271-4

Department of Medicine, Albert Einstein College of Medicine, 1300 Morris Park Ave., Bronx, NY 10461, USA.

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July 2004

Effects of voriconazole on Cryptococcus neoformans.

Antimicrob Agents Chemother 2004 Jun;48(6):2014-20

Division of Infectious Diseases, Department of Medicine, Albert Einstein College of Medicine, 1300 Morris Park Ave., Bronx, NY 10461, USA.

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June 2004

Immunoreactivity of cryptococcal antigen is not stable under prolonged incubations in human serum.

J Clin Microbiol 2004 Jun;42(6):2786-8

Department of Medicine, Albert Einstein College of Medicine, 1300 Morris Park Ave., Golding 701, Bronx, NY 10461, USA.

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June 2004

Experimental modulation of capsule size in Cryptococcus neoformans.

Biol Proced Online 2004 3;6:10-15. Epub 2004 Mar 3.

Department of Microbiology and Immunology, Albert Einstein College of Medicine. 1300 Morris Park Avenue, Bronx, New York 10461. USA.

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March 2004

Induction of capsule growth in Cryptococcus neoformans by mammalian serum and CO(2).

Infect Immun 2003 Nov;71(11):6155-64

Departments of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York 10461, USA.

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November 2003

The efficacy of complement-mediated phagocytosis of Cryptococcus neoformans is dependent on the location of C3 in the polysaccharide capsule and involves both direct and indirect C3-mediated interactions.

Eur J Immunol 2003 Jul;33(7):1957-67

Department of Microbiology and Immunology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA.

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July 2003

Trehalose accumulation induced during the oxidative stress response is independent of TPS1 mRNA levels in Candida albicans.

Int Microbiol 2003 Jun 29;6(2):121-5. Epub 2003 May 29.

Unidad de Bioquímica y Genética de Levaduras, Instituto de Investigaciones Biomédicas, CSIC, Madrid, Spain.

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June 2003

More is not necessarily better: prozone-like effects in passive immunization with IgG.

J Immunol 2003 Apr;170(7):3621-30

Department of Medicine, Division of Infectious Diseases, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

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April 2003

Generation of disruption cassettes in vivo using a PCR product and Saccharomyces cerevisiae.

Authors:
Oscar Zaragoza

J Microbiol Methods 2003 Jan;52(1):141-5

Instituto de Investigaciones Biomédicas Alberto Sols CSIC-UAM, C/Arturo Duperier 4, Madrid 28029, Spain.

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January 2003

Protective role of trehalose during severe oxidative stress caused by hydrogen peroxide and the adaptive oxidative stress response in Candida albicans.

Microbiology 2002 Aug;148(Pt 8):2599-606

Area de Microbiologia, Facultad de Biologia, Universidad de Murcia, Campus de Espinardo, E-30071 Murcia, Spain.

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August 2002

Disruption in Candida albicans of the TPS2 gene encoding trehalose-6-phosphate phosphatase affects cell integrity and decreases infectivity.

Microbiology 2002 May;148(Pt 5):1281-90

Instituto de Investigaciones Biomédicas Alberto Sols CSIC-UAM, Unidad de Bioquímica y Genética de Levaduras, 28029 Madrid, Spain.

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May 2002