Oscar R Benavente

Oscar R Benavente

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Oscar R Benavente

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Publisher Correction: Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes.

Authors:
Rainer Malik Ganesh Chauhan Matthew Traylor Muralidharan Sargurupremraj Yukinori Okada Aniket Mishra Loes Rutten-Jacobs Anne-Katrin Giese Sander W van der Laan Solveig Gretarsdottir Christopher D Anderson Michael Chong Hieab H H Adams Tetsuro Ago Peter Almgren Philippe Amouyel Hakan Ay Traci M Bartz Oscar R Benavente Steve Bevan Giorgio B Boncoraglio Robert D Brown Adam S Butterworth Caty Carrera Cara L Carty Daniel I Chasman Wei-Min Chen John W Cole Adolfo Correa Ioana Cotlarciuc Carlos Cruchaga John Danesh Paul I W de Bakker Anita L DeStefano Marcel den Hoed Qing Duan Stefan T Engelter Guido J Falcone Rebecca F Gottesman Raji P Grewal Vilmundur Gudnason Stefan Gustafsson Jeffrey Haessler Tamara B Harris Ahamad Hassan Aki S Havulinna Susan R Heckbert Elizabeth G Holliday George Howard Fang-Chi Hsu Hyacinth I Hyacinth M Arfan Ikram Erik Ingelsson Marguerite R Irvin Xueqiu Jian Jordi Jiménez-Conde Julie A Johnson J Wouter Jukema Masahiro Kanai Keith L Keene Brett M Kissela Dawn O Kleindorfer Charles Kooperberg Michiaki Kubo Leslie A Lange Carl D Langefeld Claudia Langenberg Lenore J Launer Jin-Moo Lee Robin Lemmens Didier Leys Cathryn M Lewis Wei-Yu Lin Arne G Lindgren Erik Lorentzen Patrik K Magnusson Jane Maguire Ani Manichaikul Patrick F McArdle James F Meschia Braxton D Mitchell Thomas H Mosley Michael A Nalls Toshiharu Ninomiya Martin J O'Donnell Bruce M Psaty Sara L Pulit Kristiina Rannikmäe Alexander P Reiner Kathryn M Rexrode Kenneth Rice Stephen S Rich Paul M Ridker Natalia S Rost Peter M Rothwell Jerome I Rotter Tatjana Rundek Ralph L Sacco Saori Sakaue Michele M Sale Veikko Salomaa Bishwa R Sapkota Reinhold Schmidt Carsten O Schmidt Ulf Schminke Pankaj Sharma Agnieszka Slowik Cathie L M Sudlow Christian Tanislav Turgut Tatlisumak Kent D Taylor Vincent N S Thijs Gudmar Thorleifsson Unnur Thorsteinsdottir Steffen Tiedt Stella Trompet Christophe Tzourio Cornelia M van Duijn Matthew Walters Nicholas J Wareham Sylvia Wassertheil-Smoller James G Wilson Kerri L Wiggins Qiong Yang Salim Yusuf Joshua C Bis Tomi Pastinen Arno Ruusalepp Eric E Schadt Simon Koplev Johan L M Björkegren Veronica Codoni Mete Civelek Nicholas L Smith David A Trégouët Ingrid E Christophersen Carolina Roselli Steven A Lubitz Patrick T Ellinor E Shyong Tai Jaspal S Kooner Norihiro Kato Jiang He Pim van der Harst Paul Elliott John C Chambers Fumihiko Takeuchi Andrew D Johnson Dharambir K Sanghera Olle Melander Christina Jern Daniel Strbian Israel Fernandez-Cadenas W T Longstreth Arndt Rolfs Jun Hata Daniel Woo Jonathan Rosand Guillaume Pare Jemma C Hopewell Danish Saleheen Kari Stefansson Bradford B Worrall Steven J Kittner Sudha Seshadri Myriam Fornage Hugh S Markus Joanna M M Howson Yoichiro Kamatani Stephanie Debette Martin Dichgans

Nat Genet 2019 Jul;51(7):1192-1193

Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany.

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http://dx.doi.org/10.1038/s41588-019-0449-0DOI Listing
July 2019

The uncertain role for phosphodiesterase inhibitors in stroke prevention.

Lancet Neurol 2019 Jun;18(6):515-517

Vancouver Stroke Programme, University of British Columbia and Vancouver General Hospital, Vancouver, BC, Canada.

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https://linkinghub.elsevier.com/retrieve/pii/S14744422193016
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http://dx.doi.org/10.1016/S1474-4422(19)30165-6DOI Listing
June 2019

Effect of Postural Hypotension on Recurrent Stroke: Secondary Prevention of Small Subcortical Strokes (SPS3) Study.

J Stroke Cerebrovasc Dis 2019 May 27. Epub 2019 May 27.

Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota. Electronic address:

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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2019.04.009DOI Listing
May 2019

Genetic and lifestyle risk factors for MRI-defined brain infarcts in a population-based setting.

Authors:
Ganesh Chauhan Hieab H H Adams Claudia L Satizabal Joshua C Bis Alexander Teumer Muralidharan Sargurupremraj Edith Hofer Stella Trompet Saima Hilal Albert Vernon Smith Xueqiu Jian Rainer Malik Matthew Traylor Sara L Pulit Philippe Amouyel Bernard Mazoyer Yi-Cheng Zhu Sara Kaffashian Sabrina Schilling Gary W Beecham Thomas J Montine Gerard D Schellenberg Olafur Kjartansson Vilmundur Guðnason David S Knopman Michael E Griswold B Gwen Windham Rebecca F Gottesman Thomas H Mosley Reinhold Schmidt Yasaman Saba Helena Schmidt Fumihiko Takeuchi Shuhei Yamaguchi Toru Nabika Norihiro Kato Kumar B Rajan Neelum T Aggarwal Philip L De Jager Denis A Evans Bruce M Psaty Jerome I Rotter Kenneth Rice Oscar L Lopez Jiemin Liao Christopher Chen Ching-Yu Cheng Tien Y Wong Mohammad K Ikram Sven J van der Lee Najaf Amin Vincent Chouraki Anita L DeStefano Hugo J Aparicio Jose R Romero Pauline Maillard Charles DeCarli Joanna M Wardlaw Maria Del C Valdés Hernández Michelle Luciano David Liewald Ian J Deary John M Starr Mark E Bastin Susana Muñoz Maniega P Eline Slagboom Marian Beekman Joris Deelen Hae-Won Uh Robin Lemmens Henry Brodaty Margaret J Wright David Ames Giorgio B Boncoraglio Jemma C Hopewell Ashley H Beecham Susan H Blanton Clinton B Wright Ralph L Sacco Wei Wen Anbupalam Thalamuthu Nicola J Armstrong Elizabeth Chong Peter R Schofield John B Kwok Jeroen van der Grond David J Stott Ian Ford J Wouter Jukema Meike W Vernooij Albert Hofman André G Uitterlinden Aad van der Lugt Katharina Wittfeld Hans J Grabe Norbert Hosten Bettina von Sarnowski Uwe Völker Christopher Levi Jordi Jimenez-Conde Pankaj Sharma Cathie L M Sudlow Jonathan Rosand Daniel Woo John W Cole James F Meschia Agnieszka Slowik Vincent Thijs Arne Lindgren Olle Melander Raji P Grewal Tatjana Rundek Kathy Rexrode Peter M Rothwell Donna K Arnett Christina Jern Julie A Johnson Oscar R Benavente Sylvia Wasssertheil-Smoller Jin-Moo Lee Quenna Wong Braxton D Mitchell Stephen S Rich Patrick F McArdle Mirjam I Geerlings Yolanda van der Graaf Paul I W de Bakker Folkert W Asselbergs Velandai Srikanth Russell Thomson Rebekah McWhirter Chris Moran Michele Callisaya Thanh Phan Loes C A Rutten-Jacobs Steve Bevan Christophe Tzourio Karen A Mather Perminder S Sachdev Cornelia M van Duijn Bradford B Worrall Martin Dichgans Steven J Kittner Hugh S Markus Mohammad A Ikram Myriam Fornage Lenore J Launer Sudha Seshadri W T Longstreth Stéphanie Debette

Neurology 2019 Jan 16. Epub 2019 Jan 16.

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http://dx.doi.org/10.1212/WNL.0000000000006851DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369905PMC
January 2019

Rivaroxaban for Stroke Prevention after Embolic Stroke of Undetermined Source.

N Engl J Med 2018 Jun 16;378(23):2191-2201. Epub 2018 May 16.

From the Departments of Medicine-Neurology (R.G.H., M.S., A.S.), Health Research Methods, Evidence, and Impact (S.I.B.), Pathology and Molecular Medicine (G. Pare), and Medicine-Cardiology (S.J.C.), Population Health Research Institute (B.S., P.S., E.T.), and the Thrombosis and Atherosclerosis Research Institute and McMaster University (J.I.W.), Hamilton, ON, the Vancouver Stroke Program, University of British Columbia, Vancouver (O.R.B.), and Sunnybrook Health Sciences Centre, University of Toronto, Toronto (C.J.) - all in Canada; Bayer, Wuppertal (H.M.), Klinik für Neurologie, Charité-Universitätsmedizin Berlin (M.E.), and Bayer (B.K.), Berlin, and Bayer, Leverkusen (C.P.) - all in Germany; the Department of Neurology, University of Pennsylvania, Philadelphia (S.E.K.), and Janssen Research and Development, Spring House (G. Peters) - both in Pennsylvania; Bayer U.S., Pharmaceuticals Clinical Development Thrombosis, Whippany, NJ (S.D.B.); Clínica Alemana de Santiago, Santiago, Chile (P.L.); the Department of Neurology and Stroke Center, Beijing Tiantan Hospital, Beijing (Yongjun Wang, Yilong Wang); Hospital Germans Trias i Pujol, Universitat Autònoma de Barcelona, Barcelona (A.D.); Pirogov Russian National Research Medical University, Moscow (N.S.); International Clinical Research Center and Neurology Department, St. Anne's University Hospital, Brno, Czech Republic (R.M.); Centro Hospitalar e Universitário de Coimbra, Hospitais da Universidade de Coimbra, Coimbra, Portugal (L.C.); the Department of Clinical Sciences (Neurology), Lund University, and the Department of Neurology and Rehabilitation Medicine, Skåne University Hospital, Lund (A.L.), and the Department of Clinical Neuroscience-Neurology, Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Gothenburg (T.T.) - all in Sweden; Instituto Nacional de Neurología y Neurocirugía, Mexico City (A.A.); Hospital St. John of God, Sigmund Freud Private University, Medical Faculty, Vienna (W.L.); the 2nd Department of Neurology, Institute of Psychiatry and Neurology, and the Department of Pharmacology, Medical University of Warsaw, Warsaw, Poland (A.C.); the Department of Internal Medicine, University Hospital Basel, Basel, Switzerland (J.E.); Irmandade da Santa Casa de Misericórdia de São Paulo, São Paulo (R.J.G.); Assistance Publique-Hôpitaux de Paris, Bichat Hospital, Paris-Diderot, Sorbonne Paris Cité University, Paris (P.A.); Institute for Neurological Research-Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia, Buenos Aires (S.F.A.); the Department of Neurology, Helsinki University Central Hospital, Helsinki (T.T.); Imperial College London, London (R.V.); Medical School, University of Western Australia, and Sir Charles Gairdner Hospital, Perth, Australia (G.J.H.); the Department of Human Neurosciences, Sapienza University of Rome, Rome (D.T.); the Department of Neurology, Semmelweis University, Budapest, Hungary (D.B.); International University of Health and Welfare, Sanno Hospital and Sanno Medical Center, Tokyo (S.U.); the Department of Medicine, University of Thessaly, Larissa, Greece (G.N.); Seoul National University College of Medicine, Seoul National University Hospital, Seoul, South Korea (B.-W.Y.); the Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel, Brussels (R.B.); the Department of Neurology, ZorgSaam Hospital, Terneuzen, the Netherlands (R.B.); Institute of Neuroscience and Psychology, University of Glasgow, Queen Elizabeth University Hospital, Glasgow, United Kingdom (K.W.M.); Shaare Zedek Medical Center, Jerusalem (N.B.); the Department of Neurology, Selcuk University, Konya, Turkey (S.O.); Health Research Board Clinical Research Facility, National University of Ireland, Galway (M.J.O.); Tiervlei Trial Centre and Head of Internal Medicine Karl Bremer Hospital, Bellville, South Africa (M.M.D.V.B.); and Baylor College of Medicine, Houston (W.F.P.).

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http://dx.doi.org/10.1056/NEJMoa1802686DOI Listing
June 2018

Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes.

Authors:
Rainer Malik Ganesh Chauhan Matthew Traylor Muralidharan Sargurupremraj Yukinori Okada Aniket Mishra Loes Rutten-Jacobs Anne-Katrin Giese Sander W van der Laan Solveig Gretarsdottir Christopher D Anderson Michael Chong Hieab H H Adams Tetsuro Ago Peter Almgren Philippe Amouyel Hakan Ay Traci M Bartz Oscar R Benavente Steve Bevan Giorgio B Boncoraglio Robert D Brown Adam S Butterworth Caty Carrera Cara L Carty Daniel I Chasman Wei-Min Chen John W Cole Adolfo Correa Ioana Cotlarciuc Carlos Cruchaga John Danesh Paul I W de Bakker Anita L DeStefano Marcel den Hoed Qing Duan Stefan T Engelter Guido J Falcone Rebecca F Gottesman Raji P Grewal Vilmundur Gudnason Stefan Gustafsson Jeffrey Haessler Tamara B Harris Ahamad Hassan Aki S Havulinna Susan R Heckbert Elizabeth G Holliday George Howard Fang-Chi Hsu Hyacinth I Hyacinth M Arfan Ikram Erik Ingelsson Marguerite R Irvin Xueqiu Jian Jordi Jiménez-Conde Julie A Johnson J Wouter Jukema Masahiro Kanai Keith L Keene Brett M Kissela Dawn O Kleindorfer Charles Kooperberg Michiaki Kubo Leslie A Lange Carl D Langefeld Claudia Langenberg Lenore J Launer Jin-Moo Lee Robin Lemmens Didier Leys Cathryn M Lewis Wei-Yu Lin Arne G Lindgren Erik Lorentzen Patrik K Magnusson Jane Maguire Ani Manichaikul Patrick F McArdle James F Meschia Braxton D Mitchell Thomas H Mosley Michael A Nalls Toshiharu Ninomiya Martin J O'Donnell Bruce M Psaty Sara L Pulit Kristiina Rannikmäe Alexander P Reiner Kathryn M Rexrode Kenneth Rice Stephen S Rich Paul M Ridker Natalia S Rost Peter M Rothwell Jerome I Rotter Tatjana Rundek Ralph L Sacco Saori Sakaue Michele M Sale Veikko Salomaa Bishwa R Sapkota Reinhold Schmidt Carsten O Schmidt Ulf Schminke Pankaj Sharma Agnieszka Slowik Cathie L M Sudlow Christian Tanislav Turgut Tatlisumak Kent D Taylor Vincent N S Thijs Gudmar Thorleifsson Unnur Thorsteinsdottir Steffen Tiedt Stella Trompet Christophe Tzourio Cornelia M van Duijn Matthew Walters Nicholas J Wareham Sylvia Wassertheil-Smoller James G Wilson Kerri L Wiggins Qiong Yang Salim Yusuf Joshua C Bis Tomi Pastinen Arno Ruusalepp Eric E Schadt Simon Koplev Johan L M Björkegren Veronica Codoni Mete Civelek Nicholas L Smith David A Trégouët Ingrid E Christophersen Carolina Roselli Steven A Lubitz Patrick T Ellinor E Shyong Tai Jaspal S Kooner Norihiro Kato Jiang He Pim van der Harst Paul Elliott John C Chambers Fumihiko Takeuchi Andrew D Johnson Dharambir K Sanghera Olle Melander Christina Jern Daniel Strbian Israel Fernandez-Cadenas W T Longstreth Arndt Rolfs Jun Hata Daniel Woo Jonathan Rosand Guillaume Pare Jemma C Hopewell Danish Saleheen Kari Stefansson Bradford B Worrall Steven J Kittner Sudha Seshadri Myriam Fornage Hugh S Markus Joanna M M Howson Yoichiro Kamatani Stephanie Debette Martin Dichgans

Nat Genet 2018 04 12;50(4):524-537. Epub 2018 Mar 12.

Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany.

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http://dx.doi.org/10.1038/s41588-018-0058-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5968830PMC
April 2018

Impact of Clopidogrel Therapy on Mortality and Cancer in Patients With Cardiovascular and Cerebrovascular Disease: A Patient-Level Meta-Analysis.

Circ Cardiovasc Interv 2018 01;11(1):e005795

From the Cardiology Division, Department of Medicine, Massachusetts General Hospital (S.E.), Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital (D.L.B., L.M.), Smith Center for Outcomes Research in Cardiology, Department of Medicine, Beth-Israel Deaconess Medical Center (R.W.Y.), Harvard Medical School, Boston, MA (S.E., D.L.B., R.W.Y., L.M.); Baim Institute for Clinical Research, Boston, MA (S.E., G.D., Y.L., W.-H.H., R.W.Y., L.M.); Department of Biostatistics, Boston University School of Public Health, MA (G.D.); University of British Columbia, Vancouver, Canada (O.R.B.); Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada (S.J.C., S.Y.); and Scripps Translational Science Institute, La Jolla, CA (S.R.S.).

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http://dx.doi.org/10.1161/CIRCINTERVENTIONS.117.005795DOI Listing
January 2018

Microbleeds, Cerebral Hemorrhage, and Functional Outcome After Stroke Thrombolysis.

Stroke 2017 08;48(8):2084-2090

From the Stroke Research Centre, UCL Institute of Neurology, London, United Kingdom (A.C., D.W., D.J.W.); Hemorrhagic Stroke Research Group, Massachusetts General Hospital, Boston (A.C.); Departments of Neurology and Radiology, Hôpital Sainte-Anne, Université Paris Descartes, France (G.T., C.O., M.E.-G., J.-C.B.); Department of Neurology, the 2nd Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, China (S.Y., M.L.); Department of Neurology and Center for Stroke Research, Charite Universitätsmedizin, Berlin, Germany (J.F.S., H.E., C.H.N.); Department of Diagnostic and Interventional Neuroradiology, and Neurology, Inselspital, University Hospital Bern, Switzerland (P.P.K.-G., M.E.-K., H.P.M., S.J.); Department of Neurology, Tokai University School of Medicine, Japan (W.T., Y.M., S.T.); Department of Neurology, University of Arizona, Tucson (C.S.K.); UCLA Comprehensive Stroke Center, Geffen School of Medicine, Los Angeles (J.L.S.); Univ. Lille, Inserm, CHU Lille, U1171, Degenerative and Vascular Cognitive Disorders, France (A.S., S.M., C.C.); Department of Neurology, Austin Health and Florey Institute, Heidelberg, Victoria, Australia (V.T.); Department of Statistical Science, University College London, United Kingdom (Z.F., G.A.); Department of Medicine (Neurology), McMaster University and Population Health Research Institute, Hamilton, Ontario, Canada (A.S.); Stanford Stroke Center, Palo Alto, CA (G.W.A.); Division of Neurology, Stroke and Cerebrovascular Health Program, University of British Columbia Hospital, Vancouver, Canada (O.R.B.); Lysholm Department of Neuroradiology, National Hospital, London, United Kingdom (H.R.J.); Department of Neurological Science, Nippon Medical School Graduate School of Medicine, Tokyo, Japan (J.A., K.K.); and Department of Rehabilitation Medicine, the Jikei University School of Medicine, Tokyo, Japan (W.K.).

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https://www.ahajournals.org/doi/10.1161/STROKEAHA.116.012992
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http://dx.doi.org/10.1161/STROKEAHA.116.012992DOI Listing
August 2017

Analyses of Randomized Clinical Trial for the Effect of Clopidogrel Added to Aspirin on Kidney Function.

Clin J Am Soc Nephrol 2017 Jul 26;12(7):1040-1047. Epub 2017 Apr 26.

The Kidney Health Research Collaborative, University of California, San Francisco, California;

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http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.00100117
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http://dx.doi.org/10.2215/CJN.00100117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5498342PMC
July 2017

Pharmacogenetic Associations of β1-Adrenergic Receptor Polymorphisms With Cardiovascular Outcomes in the SPS3 Trial (Secondary Prevention of Small Subcortical Strokes).

Stroke 2017 05 28;48(5):1337-1343. Epub 2017 Mar 28.

From the Department of Pharmacotherapy and Translational Research, Center for Pharmacogenomics, College of Pharmacy, University of Florida, Gainesville (O.M., C.W.M., Y.G., J.A.J.); Department of Epidemiology and Biostatistics, Dornsife School of Public Health, Drexel University, Philadelphia, PA (L.A.M.); College of Pharmacy, University of Texas, Austin (R.L.T.); Division of Endocrinology, Diabetes and Nutrition and Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore (R.B.H., A.R.S., B.D.M.); Department of Neurology, University of British Columbia, Vancouver, Canada (O.R.B.); and Geriatrics Research and Education Clinical Center, Baltimore Veterans Administration Medical Center, MD (B.D.M.).

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http://dx.doi.org/10.1161/STROKEAHA.116.015936DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5404951PMC
May 2017

Morphological classification of penetrating artery pontine infarcts and association with risk factors and prognosis: The SPS3 trial.

Int J Stroke 2016 06 8;11(4):412-9. Epub 2016 Mar 8.

Center for Brain Health, and Division of Neurology, University of British Columbia, Vancouver BC Canada

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http://dx.doi.org/10.1177/1747493016637366DOI Listing
June 2016

High Prevalence of Cerebral Microbleeds in Inner City Young Stroke Patients.

J Stroke Cerebrovasc Dis 2016 Apr 13;25(4):733-8. Epub 2016 Jan 13.

Department of Medicine (Neurology), University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2015.11.022DOI Listing
April 2016

Inflammatory Markers and Outcomes After Lacunar Stroke: Levels of Inflammatory Markers in Treatment of Stroke Study.

Stroke 2016 Mar;47(3):659-67

From the Department of Neurology, College of Physicians and Surgeons (A.K.B., J.M.L., M.S.V.E.) and Department of Epidemiology, Mailman School of Public Health (A.K.B., M.S.V.E.), Columbia University, New York; Department of Epidemiology and Biostatistics, Dornsife School of Public Health, Drexel University, Philadelphia, PA (L.A.M.); Department of Biostatistics, School of Public Health, University of Alabama at Birmingham (Y.Z.); Department of Neurological Sciences, Universidad de Especialidades Espíritu Santo, Guayaquil, Ecuador (O.H.D.B.); and Department of Neurology, University of British Columbia, Vancouver, Canada (O.R.B.).

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http://dx.doi.org/10.1161/STROKEAHA.115.012166DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4766076PMC
March 2016

Achieved Blood Pressure and Outcomes in the Secondary Prevention of Small Subcortical Strokes Trial.

Hypertension 2016 Jan 9;67(1):63-9. Epub 2015 Nov 9.

From the School of Biological and Population Health Sciences, Oregon State University, Corvallis (M.C.O.); Department of Biostatistics, University of Alabama at Birmingham (L.A.M.); Division of Nephrology, Department of Internal Medicine, Bone and Mineral Metabolism, University of Kentucky, Lexington (B.P.S.); Department of Health Restoration and Care Systems Management, School of Nursing, University of Texas Health Science Center, San Antonio (C.L.W.); Department of Medicine, University of California, San Francisco (C.A.P.); Center for Brain Health, Department of Medicine, University of British Columbia, Vancouver, Canada (T.S.F., O.R.B.); Population Health Research Institute, Hamilton, CA (R.G.H.); and Renal Associates PA, San Antonio, TX (P.E.P.).

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.115.06480DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4679688PMC
January 2016

Effect of addition of clopidogrel to aspirin on stroke incidence: Meta-analysis of randomized trials.

Int J Stroke 2015 Jul 22;10(5):686-91. Epub 2013 May 22.

Department of Medicine (Neurology), Brain Research Center, University of British Columbia, Vancouver, BC, Canada.

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http://dx.doi.org/10.1111/ijs.12050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3971006PMC
July 2015

Should Blood Pressure Targets After Lacunar Stroke Vary by Body Size? The SPS3 Trial.

Am J Hypertens 2015 Jun 1;28(6):756-64. Epub 2014 Dec 1.

Hotchkiss Brain Center, Department of Neurosciences, University of Calgary, Calgary, Alberta, Canada.

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http://dx.doi.org/10.1093/ajh/hpu228DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4447819PMC
June 2015

Left Ventricular Geometry on Transthoracic Echocardiogram and Prognosis after Lacunar Stroke: The SPS3 Trial.

J Stroke Cerebrovasc Dis 2015 Jun 1;24(6):1423-9. Epub 2015 Apr 1.

Division of Neurology, Center for Brain Health, University of British Columbia, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2015.03.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4457650PMC
June 2015

Vertebrobasilar ectasia in patients with lacunar stroke: the secondary prevention of small subcortical strokes trial.

J Stroke Cerebrovasc Dis 2015 May 25;24(5):1052-8. Epub 2015 Mar 25.

Division of Neurology, Faculty of Medicine, Brain Research Center, University of British Columbia, Vancouver, British Columbia, Canada; Division of Neurology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.

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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2014.12.039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4408219PMC
May 2015

CYP2C19 metabolizer status and clopidogrel efficacy in the Secondary Prevention of Small Subcortical Strokes (SPS3) study.

J Am Heart Assoc 2015 May 27;4(6):e001652. Epub 2015 May 27.

Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, MD (B.D.M., R.B.H., J.P.L., A.R.S.) Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, MD (B.D.M., R.B.H., J.P.L., A.R.S.) Geriatric Research and Education Clinical Center, Veterans Administration Medical Center, Baltimore, MD (B.D.M., A.R.S.).

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http://dx.doi.org/10.1161/JAHA.114.001652DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4599525PMC
May 2015

Efficacy of antiplatelet therapy in secondary prevention following lacunar stroke: pooled analysis of randomized trials.

Stroke 2015 Apr 26;46(4):1014-23. Epub 2015 Feb 26.

From the Institute of Cardiovascular Sciences, University of Manchester, Manchester, UK (C.S.K.); Institute of Applied Health Sciences, School of Medicine and Dentistry, University of Aberdeen, Aberdeen, Scotland, UK (C.S.K., P.K.M.); Department of Medicine, McMaster University/Population Health Research Institute, Hamilton, Ontario, Canada (A.S.); Department of Surgery, Addenbrooke's Hospital, Cambridge, UK (H.C.C.); Department of Medicine and Health Sciences, Norwich Medical School, University of East Anglia, Norwich Research Park, Norwich, UK (Y.K.L.); and Department of Medicine, Brain Research Centre, University of British Columbia, Vancouver Stroke Program, Vancouver, Canada (O.R.B.).

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http://dx.doi.org/10.1161/STROKEAHA.114.008422DOI Listing
April 2015

Long-term disability after lacunar stroke: secondary prevention of small subcortical strokes.

Neurology 2015 Mar 6;84(10):1002-8. Epub 2015 Feb 6.

From the Department of Neurology (M.S.D.), Mount Sinai School of Medicine, New York, NY; Department of Biostatistics (L.A.M.), University of Alabama at Birmingham; School of Nursing (C.L.W.), University of Texas Health Sciences Center, San Antonio; Department of Neurology (K.L.), University of Minnesota Medical Center, Minneapolis; Department of Neurology (O.R.B.), University of British Columbia, Vancouver, Canada; Departments of Neurology and Epidemiology (M.S.V.E.), Columbia University, New York, NY.

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http://www.neurology.org/cgi/doi/10.1212/WNL.000000000000133
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http://dx.doi.org/10.1212/WNL.0000000000001331DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4352098PMC
March 2015

Clinical-MRI correlations in a multiethnic cohort with recent lacunar stroke: the SPS3 trial.

Int J Stroke 2014 Dec 27;9(8):1057-64. Epub 2014 May 27.

Department of Medicine, Division of Neurology, Brain Research Center, University of British Columbia, Vancouver, Canada.

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http://dx.doi.org/10.1111/ijs.12282DOI Listing
December 2014

Effects of long-term blood pressure lowering and dual antiplatelet treatment on cognitive function in patients with recent lacunar stroke: a secondary analysis from the SPS3 randomised trial.

Lancet Neurol 2014 Dec 23;13(12):1177-85. Epub 2014 Oct 23.

Division of Neurology, Department of Medicine, Brain Research Centre, University of British Columbia, Vancouver, BC, Canada. Electronic address:

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http://dx.doi.org/10.1016/S1474-4422(14)70224-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4284947PMC
December 2014

Predictors of mortality in patients with lacunar stroke in the secondary prevention of small subcortical strokes trial.

Stroke 2014 Oct 26;45(10):2989-94. Epub 2014 Aug 26.

From the Divisions of Neurology (M.S., R.G.H.) and Cardiology (S.J.C.), Department of Medicine, McMaster University/Population Health Research Institute, Hamilton, Ontario, Canada; Biostatistics Consultant, Minot, ND (L.A.P.); Division of Neurology, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada (O.R.B.); Department of Neurology, University of Minnesota, Minneapolis (D.C.A.); Department of Neurology, University of Texas Health Science Center, San Antonio (S.P.); and Department of Biostatistics, University of Iowa, Iowa City (C.S.C.).

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http://dx.doi.org/10.1161/STROKEAHA.114.005789DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4175186PMC
October 2014

Clinical correlates of infarct shape and volume in lacunar strokes: the Secondary Prevention of Small Subcortical Strokes trial.

Stroke 2014 Oct 4;45(10):2952-8. Epub 2014 Sep 4.

From the Division of Neurology, Department of Medicine, Brain Research Centre, University of British Columbia, Vancouver, British Columbia, Canada (N.A., M.N., T.S.F., F.C., O.R.B.); Biostatistics Consultant, Minot, ND (L.A.P.); Department of Radiology, University of Texas Health Sciences Centre, San Antonio (C.B.); Department of Biostatistics, University of Alabama at Birmingham (L.A.M.); Department of Neurology, Hennepin County Medical Center and the University of Minnesota, Minneapolis (D.C.A.); Division of Neurology, Department of Medicine, McMaster University, Hamilton, Ontatio, Canada (R.G.H.); SPS3 Coordinating Center (N.A., L.A.P., M.N., T.S.F., C.B., F.C., R.G.H., O.R.B.); and SPS3 Statistical Center (L.A.M.).

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http://dx.doi.org/10.1161/STROKEAHA.114.005211DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4198938PMC
October 2014

Lacunar strokes in patients with diabetes mellitus: risk factors, infarct location, and prognosis: the secondary prevention of small subcortical strokes study.

Stroke 2014 Sep 17;45(9):2689-94. Epub 2014 Jul 17.

From the Departments of Neurology (S.P.), Radiology (C.B.), and Medicine (P.P.), University of Texas Health Science Center, San Antonio, TX; University of Alabama at Birmingham (L.A.M.); Department of Medicine (Neurology), University of British Columbia, Vancouver, British Columbia, Canada (O.R.B.); and Department of Medicine (Neurology), McMaster University/Population Health Research Institute Hamilton, Ontario, Canada (R.G.H.).

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http://dx.doi.org/10.1161/STROKEAHA.114.005018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4146755PMC
September 2014

The relevance of living supports on antiplatelet adherence and trial participation: the SPS3 trial.

Int J Stroke 2014 Jun 24;9(4):443-8. Epub 2014 Mar 24.

Division of Neurology, Brain Research Center, The University of British Columbia, Vancouver, BC, Canada.

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http://dx.doi.org/10.1111/ijs.12267DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4167670PMC
June 2014

C-reactive protein as a prognostic marker after lacunar stroke: levels of inflammatory markers in the treatment of stroke study.

Stroke 2014 Mar 12;45(3):707-16. Epub 2014 Feb 12.

From the Department of Neurology, College of Physicians and Surgeons (M.S.V.E., J.M.L.), Department of Epidemiology, Mailman School of Public Health (M.S.V.E., J.M.L.), and Gertrude H. Sergievsky Center (M.S.V.E.), Columbia University, New York, NY; Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL (L.A.M., Y.Z.); Department of Biostatistics, University of Iowa, Iowa City, IA (C.S.C.); Department of Neurology, University of Texas at Houston, Houston, TX (A.R.); School of Medicine, Universidad Espíritu Santo-Ecuador, Guayaquil, Ecuador (O.H.D.B.); Department of Neurology, Hospital Alberto Sabogal, Lima, Peru (E.J.P.); Department of Neurology, University of Kentucky, Lexington, KY (L.C.P.); Department of Neurology, University of San Diego, San Diego, CA (B.C.M.); Department of Neurology, Pontificia Universidad Católica de Chile, Santiago, Chile (J.T.); School of Nursing and Secondary Prevention of Small Subcortical Strokes (SPS3) Coordinating Center, University of Texas Health Science Center at San Antonio, San Antonio, TX (C.W.); and Department of Medicine, Division of Neurology, University of British Columbia, Vancouver, BC, Canada (O.R.B.).

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http://dx.doi.org/10.1161/STROKEAHA.113.004562DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4114338PMC
March 2014

ASA failure: does the combination ASA/clopidogrel confer better long-term vascular protection?

Neurology 2014 Feb 2;82(5):382-9. Epub 2014 Jan 2.

From the Department of Neurology, Neurosurgery and Medicine (R.C.), McGill University, Montreal, Canada; Department of Biostatistics (Y.Z., L.A.M.), University of Alabama at Birmingham; Department of Medicine (Neurology) (R.G.H.), McMaster University, Hamilton, Canada; Hennepin County Medical Center (Neurology) (D.C.A.), University of Minnesota Medical School, Minneapolis; Department of Clinical Pharmacy (R.L.T.), University of Texas, Austin; and Department of Medicine (O.R.B.), Brain Research Center, University of British Columbia, Vancouver, Canada.

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http://dx.doi.org/10.1212/WNL.0000000000000076DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3917683PMC
February 2014

Stroke Genetics Network (SiGN) study: design and rationale for a genome-wide association study of ischemic stroke subtypes.

Stroke 2013 Oct 10;44(10):2694-702. Epub 2013 Sep 10.

From the Mayo Clinic Jacksonville, FL (J.F.M.); University of Alabama at Birmingham (D.K.A., L.A.M.); Mayo Clinic Rochester, MN (R.D.B.); Massachusetts General Hospital, Boston, MA (H.A., J.R., O.W.); University of British Columbia, Vancouver, British Columbia, Canada (O.R.B.); University of Maryland School of Medicine and Veterans Administration Medical Center, Baltimore, MD (J.W.C., P.F.M., B.D.M., A.R.S., S.J.K.); University Medical Center Utrecht, Utrecht, The Netherlands (P.I.W.d.B.); Brigham and Women's Hospital, Harvard Medical School, Boston, MA (P.I.W.d.B.); Broad Institute of Harvard, MIT, Cambridge, MA (P.I.W.d.B.); Klinikum der Universität München, Ludwig-Maximilians-University, Munich, Germany (M.D.); Johns Hopkins University, Baltimore, MD (K.F.D.); University of Texas Health Science Center at Houston (M.F.); Saint Francis Medical Center, Lynwood, CA (R.P.G.); NINDS Neurogenetics Cluster, Bethesda, MD (K.G.); IMIM-Hospital Universitari del Mar, Barcelona, Spain (J.J.C.); University of Florida, College of Pharmacy, Gainesville, FL (J.A.J.); Institute of Neuroscience and Physiology, the Sahlgrenska Academy at University of Gothenburg, Sweden (K.J., C.J.); University of Washington, Seattle, WA (C.C.L.); Washington University School of Medicine, St. Louis, MO (J.-M.L.); Lund University, Lund, Sweden (A.L.); St. George's University of London, London, United Kingdom (H.S.M.); Medical University Graz, Graz, Austria (R.S.); Brigham and Women's Hospital, Boston, MA (K.M.R.); University of Virginia, Charlottesville, VA (S.S.R., B.B.W.); Radcliffe Infirmary, Oxford, England (P.M.R.); University of Miami, Coral Gables, FL (T.R., R.L.S.); Imperial College London, London, United Kingdom (P.S.); Jagiellonian University, Krakow, Poland (A.S.); Albert Einstein College of Medicine, Bronx, NY (S.W.-S.); University of Edinburgh, Edinburgh, United Kingdom (C.S.); Universitaire Ziekenhuizen Leuven, Leuven, Belgium (V.N.S.T.); and University of Cincinnati, Cincinnati, OH (

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http://dx.doi.org/10.1161/STROKEAHA.113.001857DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4056331PMC
October 2013

Combination aspirin and clopidogrel for secondary prevention of ischemic stroke.

Curr Treat Options Cardiovasc Med 2013 Jun;15(3):348-59

Division of Neurology, (Department of Medicine), Vancouver Stroke Program, Brain Research Center, University of British Columbia, S169-2211 Wesbrook Mall, Vancouver, BC, V6T 2B5, Canada,

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http://dx.doi.org/10.1007/s11936-013-0241-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3979285PMC
June 2013

A quantitative systematic review of domain-specific cognitive impairment in lacunar stroke.

Neurology 2013 Jan;80(3):315-22

School of Population and Public Health, University of British Columbia, Vancouver, Canada.

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http://dx.doi.org/10.1212/WNL.0b013e31827deb85DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3589178PMC
January 2013

Cognitive impairment in lacunar strokes: the SPS3 trial.

Ann Neurol 2012 Sep;72(3):351-62

Division of Neurology, Department of Medicine, Brain Research Center, University of British Columbia, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1002/ana.23733DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4198173PMC
September 2012

Effect of addition of clopidogrel to aspirin on mortality: systematic review of randomized trials.

Stroke 2012 Aug;43(8):2157-62

Department of Neurology, University of Texas Health Science Center, San Antonio, Texas 78229-3900, USA.

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http://dx.doi.org/10.1161/STROKEAHA.112.656173DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3970708PMC
August 2012

Penetrating artery territory pontine infarction.

Rev Neurol Dis 2011 ;8(1-2):30-8

Division of Neurology, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada.

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March 2012

The correlates and course of depression in patients with lacunar stroke: results from the Secondary Prevention of Small Subcortical Strokes (SPS3) study.

Cerebrovasc Dis 2011 15;32(4):354-60. Epub 2011 Sep 15.

School of Nursing, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229-3900, USA.

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http://dx.doi.org/10.1159/000330350DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3712814PMC
March 2012

Current status of antiplatelet agents to prevent stroke.

Curr Neurol Neurosci Rep 2011 Feb;11(1):6-14

Department of Medicine, Division of Neurology, University of British Columbia, S169-2211 Wesbrook Mall, Vancouver, BC, V6T 2B5, Canada.

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http://dx.doi.org/10.1007/s11910-010-0162-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3970569PMC
February 2011

Reliability and validity of blood pressure measurement in the Secondary Prevention of Small Subcortical Strokes study.

Blood Press Monit 2007 Feb;12(1):1-8

Department of Medicine, Division of Nephrology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.

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http://dx.doi.org/10.1097/MBP.0b013e3280858d5bDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3970705PMC
February 2007

Development and progression of leukoaraiosis in patients with brain ischemia and carotid artery disease.

Stroke 2003 Aug 17;34(8):1913-6. Epub 2003 Jul 17.

Neurology Unit, Rabin Medical Center, Golda Campus, 7 Keren Kayemet St, Petach-Tikva 49372, Israel.

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http://dx.doi.org/10.1161/01.STR.0000080939.39414.83DOI Listing
August 2003

Prognostic importance of leukoaraiosis in patients with symptomatic internal carotid artery stenosis.

Stroke 2002 Jun;33(6):1651-5

Neurology Unit, Rabin Medical Center, Golda Campus, Petach Tikva, Israel.

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June 2002