Oscar M Tirado

Oscar M Tirado

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Oscar M Tirado

Oscar M Tirado

Publications by authors named "Oscar M Tirado"

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Targeting fusion proteins: a double edge sword?

Authors:
Oscar M Tirado

Expert Opin Ther Targets 2019 Aug 6;23(8):651-654. Epub 2019 Jun 6.

a Sarcoma Research Group , Oncobell Program, Bellvitge Biomedical Research Institute-Catalan Institute of Oncology (IDIBELL-ICO), L'Hospitalet de Llobregat , Barcelona , Spain.

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http://dx.doi.org/10.1080/14728222.2019.1628219DOI Listing
August 2019

Bcl-x inhibition enhances Dinaciclib-induced cell death in soft-tissue sarcomas.

Sci Rep 2019 Mar 7;9(1):3816. Epub 2019 Mar 7.

Sarcoma Research Group, Oncobell Program, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain.

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http://dx.doi.org/10.1038/s41598-019-40106-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405759PMC
March 2019

DNA methylation profiling opens a new phase in the search of targeted therapy against Ewing sarcoma.

Pharmacogenomics 2017 09 23;18(14):1307-1309. Epub 2017 Aug 23.

Sarcoma Research Group, Institut d'Investigació Biomèdica de Bellvitge-IDIBELL, L'Hospitalet de Llobregat, Barcelona 08908, Spain.

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http://dx.doi.org/10.2217/pgs-2017-0017DOI Listing
September 2017

Desmoplastic small round cell tumor 20 years after its discovery.

Future Oncol 2015 ;11(7):1071-81

Department of Pediatric Oncology, Hospital Sant Joan de Déu, Barcelona, Spain.

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http://dx.doi.org/10.2217/fon.15.32DOI Listing
February 2016

Cell Death Identification in Anticancer Therapy-Response.

Cancer Res 2015 Sep 18;75(17):3682. Epub 2015 Aug 18.

Sarcoma Research Group, Molecular Oncology Laboratory, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain.

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http://dx.doi.org/10.1158/0008-5472.CAN-15-1540DOI Listing
September 2015

Sirolimus plus gemcitabine: a new therapeutic combination for resistant sarcomas?

Expert Rev Anticancer Ther 2015 Mar 14;15(3):257-9. Epub 2015 Jan 14.

The Royal Marsden Hospital, Fulham Road, SW3 6JJ, London, UK.

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http://dx.doi.org/10.1586/14737140.2015.1003045DOI Listing
March 2015

"(Not) all (dead) things share the same breath": identification of cell death mechanisms in anticancer therapy.

Cancer Res 2015 Mar 27;75(6):913-7. Epub 2015 Feb 27.

Sarcoma Research Group, Molecular Oncology Laboratory, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain.

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http://dx.doi.org/10.1158/0008-5472.CAN-14-3494DOI Listing
March 2015

The dual inhibitory effect of thiostrepton on FoxM1 and EWS/FLI1 provides a novel therapeutic option for Ewing's sarcoma.

Int J Oncol 2013 Sep 12;43(3):803-12. Epub 2013 Jul 12.

Department of Radiation Medicine, Molecular Oncology Program, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC 20057, USA.

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http://dx.doi.org/10.3892/ijo.2013.2016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3787886PMC
September 2013

Targeted therapies in sarcomas: challenging the challenge.

Sarcoma 2012 3;2012:626094. Epub 2012 Jun 3.

Laboratori d'Oncología Molecular, Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), L'Hospitalet de Llobregat, 08908 Barcelona, Spain.

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http://dx.doi.org/10.1155/2012/626094DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3372278PMC
August 2012

2-deoxyglucose induces Noxa-dependent apoptosis in alveolar rhabdomyosarcoma.

Cancer Res 2011 Nov 12;71(21):6796-806. Epub 2011 Sep 12.

Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet, Barcelona, Spain.

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http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
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http://dx.doi.org/10.1158/0008-5472.CAN-11-0759DOI Listing
November 2011

Auto-stimulatory action of secreted caveolin-1 on the proliferation of Ewing's sarcoma cells.

Int J Oncol 2011 May 3;38(5):1259-65. Epub 2011 Mar 3.

Department of Radiation Medicine, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC 20057, USA.

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http://dx.doi.org/10.3892/ijo.2011.963DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3335731PMC
May 2011

Caveolin-1 in sarcomas: friend or foe?

Oncotarget 2011 Apr;2(4):305-12

Sarcoma Research Group, Bellvitge Biomedical Research Institute, L'Hospitalet de Llobregat, Barcelona, Spain.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3248165PMC
http://dx.doi.org/10.18632/oncotarget.255DOI Listing
April 2011

Caveolin-1 modulates the ability of Ewing's sarcoma to metastasize.

Mol Cancer Res 2010 Nov;8(11):1489-500

Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), Hospital Duran i Reynals-3 Planta Gran via s/n Km. 2, 7, 08907 L'Hospitalet de Llobregat, Barcelona, Spain.

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http://dx.doi.org/10.1158/1541-7786.MCR-10-0060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3679656PMC
November 2010

Caveolin-1 promotes resistance to chemotherapy-induced apoptosis in Ewing's sarcoma cells by modulating PKCalpha phosphorylation.

Int J Cancer 2010 Jan;126(2):426-36

Institut d'Investigació Biomédica de Bellvitge, Centre d'Oncología Molecular, L'Hospitalet de Llobregat, Barcelona, Spain.

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http://dx.doi.org/10.1002/ijc.24754DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2794946PMC
January 2010

Pyrazolo[1,5-a]-1,3,5-triazine as a purine bioisostere: access to potent cyclin-dependent kinase inhibitor (R)-roscovitine analogue.

J Med Chem 2009 Feb;52(3):655-63

Institut de Chimie et Biochimie Moleculaires et Supramoleculaires, UMR-CNRS 5246, Laboratoire de Chimie Organique 1, Universite de Lyon, Universite Claude Bernard-Lyon 1, Batiment Curien, 43 Boulevard du 11 Novembre 1918, F-69622 Villeurbanne, France.

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http://dx.doi.org/10.1021/jm801340zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3744883PMC
February 2009

PCPH/ENTPD5 expression confers to prostate cancer cells resistance against cisplatin-induced apoptosis through protein kinase Calpha-mediated Bcl-2 stabilization.

Cancer Res 2009 Jan;69(1):102-10

Laboratory of Experimental Carcinogenesis, Department of Radiation Medicine, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, 3970 Reservoir Road Northwest, Washington, DC 20057-1482, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-08-2922DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2614304PMC
January 2009

PCPH/ENTPD5 expression enhances the invasiveness of human prostate cancer cells by a protein kinase C delta-dependent mechanism.

Cancer Res 2007 Nov;67(22):10859-68

Laboratory of Experimental Carcinogenesis, Department of Radiation Medicine, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, District of Columbia 20057-1482, USA.

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http://cancerres.aacrjournals.org/lookup/doi/10.1158/0008-54
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http://dx.doi.org/10.1158/0008-5472.CAN-07-2041DOI Listing
November 2007

Combined transcriptional and translational targeting of EWS/FLI-1 in Ewing's sarcoma.

Clin Cancer Res 2006 Nov;12(22):6781-90

Laboratory of Experimental Carcinogenesis, Department of Radiation Medicine, V.T. Lombardi Comprehensive Cancer Center, Georgetown University, Washington, District of Columbia 20057-1482, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-06-0609DOI Listing
November 2006

Caveolin-1 (CAV1) is a target of EWS/FLI-1 and a key determinant of the oncogenic phenotype and tumorigenicity of Ewing's sarcoma cells.

Cancer Res 2006 Oct;66(20):9937-47

Laboratory of Experimental Carcinogenesis, Department of Radiation Medicine, Georgetown University Medical Center, Washington, DC 20057, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-06-0927DOI Listing
October 2006

PCPH expression is an early event in the development of testicular germ cell tumors.

Int J Oncol 2006 Mar;28(3):595-604

Department of Anatomy, Histology and Neurosciences, School of Medicine, Autónoma University, Alcalá, Spain.

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March 2006

Roscovitine is an effective inducer of apoptosis of Ewing's sarcoma family tumor cells in vitro and in vivo.

Cancer Res 2005 Oct;65(20):9320-7

Laboratory of Experimental Carcinogenesis, Department of Radiation Medicine, Georgetown University Medical Center, Washington, DC 20057-1482, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-05-1276DOI Listing
October 2005

Rapamycin induces apoptosis of JN-DSRCT-1 cells by increasing the Bax : Bcl-xL ratio through concurrent mechanisms dependent and independent of its mTOR inhibitory activity.

Oncogene 2005 May;24(20):3348-57

Laboratory of Experimental Carcinogenesis, Department of Radiation Medicine, Georgetown University Medical Center, Washington, DC, USA.

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http://www.nature.com/articles/1208471
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http://dx.doi.org/10.1038/sj.onc.1208471DOI Listing
May 2005

Estrogen receptor beta expression and apoptosis of spermatocytes of mice overexpressing a rat androgen-binding protein transgene.

Biol Reprod 2004 Nov 23;71(5):1461-8. Epub 2004 Jun 23.

Grup de Recerca en Endocrinologia Molecular, Hospital Universitari Vall d'Hebron, Pg. Vall d'Hebron, 119-129, 08035 Barcelona, Spain.

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http://dx.doi.org/10.1095/biolreprod.103.025619DOI Listing
November 2004

Deregulated expression of the PCPH proto-oncogene in human breast cancers.

Int J Oncol 2004 Oct;25(4):821-30

Department of Anatomy, Veterinary School, Universidad Complutense, Madrid, Spain.

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October 2004

Increased expression of estrogen receptor beta in pachytene spermatocytes after short-term methoxyacetic acid administration.

J Androl 2004 Jan-Feb;25(1):84-94

Unitat de Recerca Biomèdica, Hospital Materno-Infantil Vall d'Hebron, Barcelona, Spain.

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August 2004

Rapamycin induces the fusion-type independent downregulation of the EWS/FLI-1 proteins and inhibits Ewing's sarcoma cell proliferation.

Oncogene 2003 Dec;22(58):9282-7

Laboratory of Experimental Carcinogenesis, Department of Radiation Medicine, Georgetown University Medical Center, Washington, DC 20057-1482, USA.

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http://dx.doi.org/10.1038/sj.onc.1207081DOI Listing
December 2003

The PCPH oncoprotein antagonizes the proapoptotic role of the mammalian target of rapamycin in the response of normal fibroblasts to ionizing radiation.

Cancer Res 2003 Oct;63(19):6290-8

Laboratory of Experimental Carcinogenesis, Department of Radiation Medicine, Georgetown University Medical Center, 3970 Reservoir Road NW, Washington, DC 20057-1482, USA.

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October 2003

Methoxyacetic acid disregulation of androgen receptor and androgen-binding protein expression in adult rat testis.

Biol Reprod 2003 Apr 27;68(4):1437-46. Epub 2002 Nov 27.

Unitat de Recerca Biomedica, Hospital Materno-Infantil Vall d'Hebron, Barcelona, Spain.

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http://dx.doi.org/10.1095/biolreprod.102.004937DOI Listing
April 2003

Androgen-binding protein and reproduction: where do we stand?

J Androl 2002 Sep-Oct;23(5):598-609

Unitat de Recerca Biomèdica, Hospital Materno-Infantil Vall d'Hebron, Barcelona, Spain.

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February 2003

Laser capture microdissection to assess development.

Methods Enzymol 2002 ;356:145-56

Department of Cell Biology, Georgetown University Medical School, Washington, D.C. 20007, USA.

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http://dx.doi.org/10.1016/s0076-6879(02)56930-5DOI Listing
December 2002