Publications by authors named "Oscar M Rueda"

70Publications

Metabolic Imaging Detects Resistance to PI3Kα Inhibition Mediated by Persistent FOXM1 Expression in ER Breast Cancer.

Cancer Cell 2020 Oct 24;38(4):516-533.e9. Epub 2020 Sep 24.

Cancer Research UK Cambridge Institute and Department of Oncology, Li Ka Shing Centre, University of Cambridge, Cambridge, UK; Cancer Research UK Cambridge Cancer Centre, Cambridge, UK; Department of Biochemistry, University of Cambridge, Cambridge UK. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2020.08.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7562820PMC
October 2020

Landscape of G-quadruplex DNA structural regions in breast cancer.

Nat Genet 2020 09 3;52(9):878-883. Epub 2020 Aug 3.

Cancer Research UK Cambridge Institute, Li Ka Shing Centre, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1038/s41588-020-0672-8DOI Listing
September 2020

Fbxl17 is rearranged in breast cancer and loss of its activity leads to increased global O-GlcNAcylation.

Cell Mol Life Sci 2020 Jul 27;77(13):2605-2620. Epub 2019 Sep 27.

Department of Pathology at Tennis Court Road, University of Cambridge, Cambridge, CB2 1QP, UK.

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http://dx.doi.org/10.1007/s00018-019-03306-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320043PMC
July 2020

MAP3K1 and MAP2K4 mutations are associated with sensitivity to MEK inhibitors in multiple cancer models.

Cell Res 2018 07 24;28(7):719-729. Epub 2018 May 24.

Division of Molecular Carcinogenesis, Oncode Institute, The Netherlands Cancer Institute, Plesmanlaan 121, Amsterdam, 1066 CX, The Netherlands.

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http://dx.doi.org/10.1038/s41422-018-0044-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6028652PMC
July 2018

Shallow whole genome sequencing for robust copy number profiling of formalin-fixed paraffin-embedded breast cancers.

Exp Mol Pathol 2018 06 31;104(3):161-169. Epub 2018 Mar 31.

Cancer Research UK Cambridge Institute, Li Ka Shing Centre, University of Cambridge, Robinson Way, Cambridge CB2 0RE, UK; Department of Oncology, University of Cambridge, Cambridge CB2 2QQ, UK; Cambridge Breast Unit, Addenbrooke's Hospital, Cambridge University Hospital NHS Foundation Trust, NIHR Cambridge Biomedical Research Centre, Cambridge CB2 2QQ, UK; Cancer Research UK Cambridge Cancer Centre, Cambridge CB2 0QQ, UK. Electronic address:

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http://dx.doi.org/10.1016/j.yexmp.2018.03.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5993858PMC
June 2018

Computational approach to discriminate human and mouse sequences in patient-derived tumour xenografts.

BMC Genomics 2018 01 5;19(1):19. Epub 2018 Jan 5.

CRUK Cambridge Institute and Department of Oncology, University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge, CB2 0RE, UK.

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http://dx.doi.org/10.1186/s12864-017-4414-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5755132PMC
January 2018

Modeling Breast Cancer Intertumor and Intratumor Heterogeneity Using Xenografts.

Cold Spring Harb Symp Quant Biol 2016 5;81:227-230. Epub 2017 Apr 5.

Department of Oncology and Cancer Research UK Cambridge Institute, Li Ka Shing Centre, University of Cambridge, Cambridge CB2 0RE, United Kingdom.

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http://dx.doi.org/10.1101/sqb.2016.81.031112DOI Listing
February 2018

A Biobank of Breast Cancer Explants with Preserved Intra-tumor Heterogeneity to Screen Anticancer Compounds.

Cell 2016 09 15;167(1):260-274.e22. Epub 2016 Sep 15.

Department of Oncology and Cancer Research UK Cambridge Institute, Li Ka Shing Centre, University of Cambridge, Cambridge CB2 0RE, UK; Cambridge Breast Unit, NIHR Cambridge Biomedical Research Centre and Cambridge Experimental Cancer Medicine Centre at Cambridge University Hospitals NHS Foundation Trust, Cambridge CB2 2QQ, UK. Electronic address:

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5037319PMC
http://dx.doi.org/10.1016/j.cell.2016.08.041DOI Listing
September 2016

Context-Specific Effects of TGF-β/SMAD3 in Cancer Are Modulated by the Epigenome.

Cell Rep 2015 Dec 10;13(11):2480-2490. Epub 2015 Dec 10.

Cancer Research UK Cambridge Institute, Department of Oncology, University of Cambridge, Cambridge CB2 0RE, UK. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.11.040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4695334PMC
December 2015

Double-stranded microRNA mimics can induce length- and passenger strand-dependent effects in a cell type-specific manner.

RNA 2016 Feb 15;22(2):193-203. Epub 2015 Dec 15.

Cancer Research UK-Cambridge Institute, University of Cambridge, Cambridge CB2 0RE, United Kingdom.

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http://dx.doi.org/10.1261/rna.054072.115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4712670PMC
February 2016

Robust BRCA1-like classification of copy number profiles of samples repeated across different datasets and platforms.

Mol Oncol 2015 Aug 20;9(7):1274-86. Epub 2015 Mar 20.

Department of Molecular Pathology, Netherlands Cancer Institute, Amsterdam, The Netherlands; Department of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands; Division of Medical Oncology, Netherlands Cancer Institute, Amsterdam, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.molonc.2015.03.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5528812PMC
August 2015

A tumor DNA complex aberration index is an independent predictor of survival in breast and ovarian cancer.

Mol Oncol 2015 Jan 8;9(1):115-27. Epub 2014 Aug 8.

Cancer Research UK, Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK; Department of Oncology, University of Cambridge, Hills Road, Cambridge CB2 2XZ, UK; Cambridge Experimental Cancer Medicine Centre, Cambridge CB2 0RE, UK; Cambridge Breast Unit, Addenbrooke's Hospital, Cambridge University Hospital NHS Foundation Trust and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 2QQ, UK. Electronic address:

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http://dx.doi.org/10.1016/j.molonc.2014.07.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4286124PMC
January 2015

JARID1B is a luminal lineage-driving oncogene in breast cancer.

Cancer Cell 2014 Jun;25(6):762-77

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA; Broad Institute, Cambridge, MA 02141, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccr.2014.04.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4079039PMC
June 2014

Genomic and protein expression analysis reveals flap endonuclease 1 (FEN1) as a key biomarker in breast and ovarian cancer.

Mol Oncol 2014 Oct 13;8(7):1326-38. Epub 2014 May 13.

Department of Oncology, Nottingham University Hospitals, Nottingham NG51PB, UK; Academic Unit of Oncology, Division of Cancer and Stem Cells, School of Medicine, University of Nottingham, Nottingham NG51PB, UK. Electronic address:

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http://dx.doi.org/10.1016/j.molonc.2014.04.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4690463PMC
October 2014

TP53 mutation spectrum in breast cancer is subtype specific and has distinct prognostic relevance.

Clin Cancer Res 2014 Jul 6;20(13):3569-80. Epub 2014 May 6.

Authors' Affiliations: Department of Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet; The K.G. Jebsen Center for Breast Cancer Research, Institute for Clinical Medicine, Faculty of Medicine;

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http://dx.doi.org/10.1158/1078-0432.CCR-13-2943DOI Listing
July 2014

Amplification of TRIM44: pairing a prognostic target with potential therapeutic strategy.

J Natl Cancer Inst 2014 Apr 28;106(5). Epub 2014 Apr 28.

Affiliations of authors: MRC Cancer Unit, Cambridge, UK (C-AJO, CSR-I, MO, CEW, AN, RCF); Cancer Research UK Cambridge Institute, Cambridge, UK (NBS, OMR, D-eH, MIK, CC, KB); UK Cambridge Esophagogastric Centre, Addenbrooke's Hospital, Cambridge, UK (RHH).

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http://dx.doi.org/10.1093/jnci/dju050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4112924PMC
April 2014

Master regulators of FGFR2 signalling and breast cancer risk.

Nat Commun 2013 ;4:2464

1] Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge CB2 0RE, UK [2] Department of Oncology, University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK [3] [4].

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http://dx.doi.org/10.1038/ncomms3464DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3778544PMC
April 2014

Analysis of circulating tumor DNA to monitor metastatic breast cancer.

N Engl J Med 2013 Mar 13;368(13):1199-209. Epub 2013 Mar 13.

Department of Oncology, University of Cambridge and Cancer Research UK Cambridge Institute, Li Ka Shing Centre, Cambridge, United Kingdom.

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http://dx.doi.org/10.1056/NEJMoa1213261DOI Listing
March 2013

Finding common regions of alteration in copy number data.

Methods Mol Biol 2013 ;973:339-53

Cancer Research UK Cambridge Research Institute, Li Ka Shing Centre, Cambridge, UK.

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http://dx.doi.org/10.1007/978-1-62703-281-0_21DOI Listing
July 2013

A new genome-driven integrated classification of breast cancer and its implications.

EMBO J 2013 Mar 8;32(5):617-28. Epub 2013 Feb 8.

Cancer Research UK, Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge, UK.

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http://dx.doi.org/10.1038/emboj.2013.19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3590990PMC
March 2013

Penalized regression elucidates aberration hotspots mediating subtype-specific transcriptional responses in breast cancer.

Bioinformatics 2011 Oct 30;27(19):2679-85. Epub 2011 Jul 30.

Cambridge Research Institute, Cancer Research UK, Li Ka Shing Centre, Cambridge CB2 0RE, UK.

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https://academic.oup.com/bioinformatics/article-lookup/doi/1
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http://dx.doi.org/10.1093/bioinformatics/btr450DOI Listing
October 2011

waviCGH: a web application for the analysis and visualization of genomic copy number alterations.

Nucleic Acids Res 2010 Jul 27;38(Web Server issue):W182-7. Epub 2010 May 27.

Bioinformatics Unit, Spanish National Cancer Research Centre.

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http://dx.doi.org/10.1093/nar/gkq441DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2896163PMC
July 2010

Detection of recurrent copy number alterations in the genome: taking among-subject heterogeneity seriously.

BMC Bioinformatics 2009 Sep 23;10:308. Epub 2009 Sep 23.

Structural and Computational Biology Programme, Spanish National Cancer Centre (CNIO), Melchor Fernández Almagro 3, 28029 Madrid, Spain.

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http://dx.doi.org/10.1186/1471-2105-10-308DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2760535PMC
September 2009

RJaCGH: Bayesian analysis of aCGH arrays for detecting copy number changes and recurrent regions.

Bioinformatics 2009 Aug 6;25(15):1959-60. Epub 2009 May 6.

Structural Biology and Biocomputing Programme, Spanish National Cancer Center (CNIO), Madrid 28029, Spain.

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http://dx.doi.org/10.1093/bioinformatics/btp307DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2712338PMC
August 2009

ADaCGH: A parallelized web-based application and R package for the analysis of aCGH data.

PLoS One 2007 Aug 15;2(8):e737. Epub 2007 Aug 15.

Structural Biology and Biocomputing Programme, Spanish National Cancer Center, Madrid, Spain.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0000737PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1940324PMC
August 2007

Flexible and accurate detection of genomic copy-number changes from aCGH.

PLoS Comput Biol 2007 Jun 16;3(6):e122. Epub 2007 May 16.

Structural and Computational Biology Programme, Spanish National Cancer Centre (CNIO), Madrid, Spain.

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http://dx.doi.org/10.1371/journal.pcbi.0030122DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1894821PMC
June 2007

Asterias: integrated analysis of expression and aCGH data using an open-source, web-based, parallelized software suite.

Nucleic Acids Res 2007 Jul 8;35(Web Server issue):W75-80. Epub 2007 May 8.

Statistical Computing Team, Structural and Computational Biology Programme, Spanish National Cancer Center (CNIO), Melchor Fernández Almagro 3, Madrid, 28029, Spain.

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http://dx.doi.org/10.1093/nar/gkm229DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1933128PMC
July 2007

Asterias: a parallelized web-based suite for the analysis of expression and aCGH data.

Cancer Inform 2007 Feb 3;3:1-9. Epub 2007 Feb 3.

Statistical Computing Team, Structural and Computational Biology Programme, Spanish National Cancer Center (CNIO), Melchor Fernández Almagro 3, Madrid, Spain.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2675829PMC
February 2007