Oscar Lao

Oscar Lao

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Oscar Lao

Oscar Lao

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Novel taxonomy-independent deep learning microbiome approach allows for accurate classification of different forensically relevant human epithelial materials.

Forensic Sci Int Genet 2019 07 4;41:72-82. Epub 2019 Apr 4.

Department of Genetic Identification, Erasmus MC University Medical Center Rotterdam, Rotterdam, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.fsigen.2019.03.015DOI Listing
July 2019

Approximate Bayesian computation with deep learning supports a third archaic introgression in Asia and Oceania.

Nat Commun 2019 01 16;10(1):246. Epub 2019 Jan 16.

CNAG-CRG, Centre for Genomic Regulation (CRG), Barcelona Institute of Science and Technology (BIST), Baldiri i Reixach 4, 08028, Barcelona, Spain.

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http://dx.doi.org/10.1038/s41467-018-08089-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335398PMC
January 2019

Medicine in the Light of Evolution.

Genes (Basel) 2018 Dec 21;10(1). Epub 2018 Dec 21.

Population Genomics Group, Centre Nacional d'Anàlisi Genòmica, Centre de Regulació Genòmica (CRG-CNAG), Parc Científic de Barcelona, Baldiri Reixac 4, 08028 Barcelona, Catalonia, Spain.

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http://dx.doi.org/10.3390/genes10010003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356894PMC
December 2018

Mutation analysis at 17 Y-STR loci (Yfiler) in father-son pairs of male pedigrees from Pakistan.

Forensic Sci Int Genet 2018 09 6;36:e17-e18. Epub 2018 Jul 6.

Department of Genetic Identification, Erasmus MC University Medical Center Rotterdam, 3000 CA Rotterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.fsigen.2018.07.001DOI Listing
September 2018

Evolutionary and Medical Consequences of Archaic Introgression into Modern Human Genomes.

Genes (Basel) 2018 Jul 18;9(7). Epub 2018 Jul 18.

Population Genomics Group, Centre Nacional d'Anàlisi Genòmica, Centre de Regulació Genòmica (CRG-CNAG), Parc Científic de Barcelona, Baldiri Reixac 4, 08028 Barcelona, Catalonia, Spain.

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http://dx.doi.org/10.3390/genes9070358DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6070777PMC
July 2018

A genomic history of Aboriginal Australia.

Nature 2016 Oct 21;538(7624):207-214. Epub 2016 Sep 21.

Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Øster Voldgade 5-7, 1350 Copenhagen, Denmark.

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http://dx.doi.org/10.1038/nature18299DOI Listing
October 2016

Chimpanzee genomic diversity reveals ancient admixture with bonobos.

Science 2016 10 27;354(6311):477-481. Epub 2016 Oct 27.

Institut de Biologia Evolutiva (Consejo Superior de Investigaciones Científicas-Universitat Pompeu Fabra), Barcelona Biomedical Research Park, Doctor Aiguader 88, Barcelona, Catalonia 08003, Spain. National Centre for Genomic Analysis-Centre for Genomic Regulation, Barcelona Institute of Science and Technology, 08028 Barcelona, Spain. Institucio Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Catalonia 08010, Spain.

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http://dx.doi.org/10.1126/science.aag2602DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5546212PMC
October 2016

Evaluation of mRNA markers for estimating blood deposition time: Towards alibi testing from human forensic stains with rhythmic biomarkers.

Forensic Sci Int Genet 2016 Mar 28;21:119-25. Epub 2015 Dec 28.

Department of Genetic Identification, Erasmus MC University Medical Centre Rotterdam, Rotterdam, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.fsigen.2015.12.008DOI Listing
March 2016

Dissecting Daily and Circadian Expression Rhythms of Clock-Controlled Genes in Human Blood.

J Biol Rhythms 2016 Feb 2;31(1):68-81. Epub 2015 Nov 2.

Department of Genetic Identification, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands

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http://dx.doi.org/10.1177/0748730415611761DOI Listing
February 2016

BMD Loci Contribute to Ethnic and Developmental Differences in Skeletal Fragility across Populations: Assessment of Evolutionary Selection Pressures.

Mol Biol Evol 2015 Nov 29;32(11):2961-72. Epub 2015 Jul 29.

Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands The Generation R Study Group, Erasmus University Medical Center, Rotterdam, The Netherlands Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands

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http://dx.doi.org/10.1093/molbev/msv170DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4651235PMC
November 2015

Detecting individual ancestry in the human genome.

Investig Genet 2015 1;6. Epub 2015 May 1.

Department of Forensic Molecular Biology, Erasmus MC University Medical Center Rotterdam, 3000 CA Rotterdam, The Netherlands ; Current address: Centro Nacional de Análisis Genómico, Baldiri Reixac, 4, Barcleona Science Park - Tower I, 08028 Barcelona, Spain.

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http://dx.doi.org/10.1186/s13323-015-0019-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4416275PMC
May 2015

Implications of population history of European Romani on genetic susceptibility to disease.

Hum Hered 2013 21;76(3-4):194-200. Epub 2014 May 21.

Institut de Biologia Evolutiva (CSIC-UPF), Departament de Ciències de la Salut i de la Vida, Universitat Pompeu Fabra, Barcelona, Spain.

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http://dx.doi.org/10.1159/000360762DOI Listing
January 2015

GAGA: a new algorithm for genomic inference of geographic ancestry reveals fine level population substructure in Europeans.

PLoS Comput Biol 2014 Feb 20;10(2):e1003480. Epub 2014 Feb 20.

Department of Forensic Molecular Biology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands.

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https://dx.plos.org/10.1371/journal.pcbi.1003480
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http://dx.doi.org/10.1371/journal.pcbi.1003480DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3930519PMC
February 2014

Effect of sleep deprivation on rhythms of clock gene expression and melatonin in humans.

Chronobiol Int 2013 Aug 5;30(7):901-9. Epub 2013 Jun 5.

Department of Forensic Molecular Biology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands.

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http://dx.doi.org/10.3109/07420528.2013.784773DOI Listing
August 2013

Clinal distribution of human genomic diversity across the Netherlands despite archaeological evidence for genetic discontinuities in Dutch population history.

Investig Genet 2013 May 20;4(1). Epub 2013 May 20.

Department of Forensic Molecular Biology, Erasmus MC University Medical Center Rotterdam, P,O, Box 2040, Rotterdam 3000 CA, Netherlands.

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http://dx.doi.org/10.1186/2041-2223-4-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3707805PMC
May 2013

Comprehensive candidate gene study highlights UGT1A and BNC2 as new genes determining continuous skin color variation in Europeans.

Hum Genet 2013 Feb 11;132(2):147-58. Epub 2012 Oct 11.

Department of Dermatology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands.

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http://link.springer.com/10.1007/s00439-012-1232-9
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http://dx.doi.org/10.1007/s00439-012-1232-9DOI Listing
February 2013

Adaptive evolution of loci covarying with the human African Pygmy phenotype.

Hum Genet 2012 Aug 11;131(8):1305-17. Epub 2012 Mar 11.

Departament de Ciències de la Salut i de la Vida, Institut de Biologia Evolutiva (CSIC-UPF), Universitat Pompeu Fabra, 08003 Barcelona, Spain.

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http://dx.doi.org/10.1007/s00439-012-1157-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3397127PMC
August 2012

Diurnal rhythms in blood cell populations and the effect of acute sleep deprivation in healthy young men.

Sleep 2012 Jul 1;35(7):933-40. Epub 2012 Jul 1.

Department of Forensic Molecular Biology, Erasmus MC University Medical Centre Rotterdam, Rotterdam, The Netherlands.

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http://dx.doi.org/10.5665/sleep.1954DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3369228PMC
July 2012

Postnatal parental smoking: an important risk factor for SIDS.

Eur J Pediatr 2011 Oct 15;170(10):1281-91. Epub 2011 Mar 15.

Department of Forensic Molecular Biology, Erasmus MC University Medical Center Rotterdam, 2040, 3000 CA, Rotterdam, The Netherlands.

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http://search.proquest.com/openview/d9c5ad4cb3b0a23ee75d93e6
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http://link.springer.com/10.1007/s00431-011-1433-6
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http://dx.doi.org/10.1007/s00431-011-1433-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3175033PMC
October 2011

IrisPlex: a sensitive DNA tool for accurate prediction of blue and brown eye colour in the absence of ancestry information.

Forensic Sci Int Genet 2011 Jun 27;5(3):170-80. Epub 2010 Mar 27.

Department of Forensic Molecular Biology, Erasmus University Medical Centre Rotterdam, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.fsigen.2010.02.004DOI Listing
June 2011

Unexpected island effects at an extreme: reduced Y chromosome and mitochondrial DNA diversity in Nias.

Mol Biol Evol 2011 Apr 8;28(4):1349-61. Epub 2010 Nov 8.

Department of Forensic Molecular Biology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1093/molbev/msq300DOI Listing
April 2011

Recent human evolution has shaped geographical differences in susceptibility to disease.

BMC Genomics 2011 Jan 24;12:55. Epub 2011 Jan 24.

Institute of Evolutionary Biology (UPF-CSIC), PRBB, Doctor Aiguader 88, 08003, Barcelona, Catalonia, Spain.

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http://dx.doi.org/10.1186/1471-2164-12-55DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3039608PMC
January 2011

Evaluating self-declared ancestry of U.S. Americans with autosomal, Y-chromosomal and mitochondrial DNA.

Hum Mutat 2010 Dec;31(12):E1875-93

Department of Forensic Molecular Biology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1002/humu.21366DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3051415PMC
December 2010

Demographic history of Oceania inferred from genome-wide data.

Curr Biol 2010 Nov 11;20(22):1983-92. Epub 2010 Nov 11.

Cologne Center for Genomics, University of Cologne, D-50931 Cologne, Germany.

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http://dx.doi.org/10.1016/j.cub.2010.10.040DOI Listing
November 2010

Statistical analysis of post mortem DNA damage-derived miscoding lesions in Neandertal mitochondrial DNA.

BMC Res Notes 2008 Jul 10;1:40. Epub 2008 Jul 10.

Institut de Biologia Evolutiva (CSIC-UPF), Dr, Aiguader 88, 08003 Barcelona, Spain.

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http://dx.doi.org/10.1186/1756-0500-1-40DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2547106PMC
July 2008

The Mediterranean paradox for susceptibility factors in coronary heart disease extends to genetics.

Ann Hum Genet 2008 Jan 7;72(Pt 1):48-56. Epub 2007 Aug 7.

Unitat de Biologia Evolutiva, Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona, Catalonia, Spain.

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http://dx.doi.org/10.1111/j.1469-1809.2007.00387.xDOI Listing
January 2008

Genome-wide analysis indicates more Asian than Melanesian ancestry of Polynesians.

Am J Hum Genet 2008 Jan;82(1):194-8

Department of Forensic Molecular Biology, Erasmus University Medical Center Rotterdam, PO Box 2040, 3000 CA Rotterdam, The Netherlands.

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http://linkinghub.elsevier.com/retrieve/pii/S000292970700016
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http://dx.doi.org/10.1016/j.ajhg.2007.09.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2253960PMC
January 2008

Identification of a candidate genetic variant for the high prevalence of type II diabetes in Polynesians.

Eur J Hum Genet 2007 May 28;15(5):584-9. Epub 2007 Feb 28.

Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany.

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http://dx.doi.org/10.1038/sj.ejhg.5201793DOI Listing
May 2007

CYP2D6 worldwide genetic variation shows high frequency of altered activity variants and no continental structure.

Pharmacogenet Genomics 2007 Feb;17(2):93-101

Department of Forensic Medicine, University of Helsinki, Finland.

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http://dx.doi.org/10.1097/01.fpc.0000239974.69464.f2DOI Listing
February 2007

Tracking down human contamination in ancient human teeth.

Mol Biol Evol 2006 Sep 29;23(9):1801-7. Epub 2006 Jun 29.

Unitat de Biologia Evolutiva, Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona, Spain.

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http://academic.oup.com/mbe/article/23/9/1801/1014297/Tracki
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http://dx.doi.org/10.1093/molbev/msl047DOI Listing
September 2006

Proportioning whole-genome single-nucleotide-polymorphism diversity for the identification of geographic population structure and genetic ancestry.

Am J Hum Genet 2006 Apr 14;78(4):680-90. Epub 2006 Feb 14.

Department of Forensic Molecular Biology, Erasmus University Medical Centre Rotterdam, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1086/501531DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1424693PMC
April 2006

The portability of tagSNPs across populations: a worldwide survey.

Genome Res 2006 Mar 8;16(3):323-30. Epub 2006 Feb 8.

Unitat de Biologia Evolutiva, Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, 08003 Barcelona, Catalonia, Spain.

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http://dx.doi.org/10.1101/gr.4138406DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1415211PMC
March 2006

Association Cluster Detector: a tool for heuristic detection of significance clusters in whole-genome scans.

Bioinformatics 2005 Sep;21 Suppl 2:ii180-1

Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona, Spain.

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http://dx.doi.org/10.1093/bioinformatics/bti1118DOI Listing
September 2005

Geographic stratification of linkage disequilibrium: a worldwide population study in a region of chromosome 22.

Hum Genomics 2004 Nov;1(6):399-409

Unitat de Biologia Evolutiva, Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona, Catalonia, Spain.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3500194PMC
November 2004

Comparative genetics of functional trinucleotide tandem repeats in humans and apes.

J Mol Evol 2004 Sep;59(3):329-39

Unitat de Biologia Evolutiva, Facultat de Ciències de la Salut i de la Vida, Universitat Pompeu Fabra, Barcelona, Spain.

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http://link.springer.com/content/pdf/10.1007/s00239-004-2628
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http://link.springer.com/10.1007/s00239-004-2628-5
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http://dx.doi.org/10.1007/s00239-004-2628-5DOI Listing
September 2004

Admixture, migrations, and dispersals in Central Asia: evidence from maternal DNA lineages.

Eur J Hum Genet 2004 Jun;12(6):495-504

Unitat de Biologia Evolutiva, Departament de Ciències de la Salut i de la Vida, Universitat Pompeu Fabra, Barcelona 08003, Spain.

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http://dx.doi.org/10.1038/sj.ejhg.5201160DOI Listing
June 2004

The west side story: MEFV haplotype in Spanish FMF patients and controls, and evidence of high LD and a recombination "hot-spot" at the MEFV locus.

Hum Mutat 2004 Apr;23(4):399

Servei d'Immunologia, Institut d'Investigacions Biomèdiques Agustí Pi i Sunyer, Hospital Clínic, Barcelona, Catalonia, Spain.

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http://dx.doi.org/10.1002/humu.9229DOI Listing
April 2004

Spatial patterns of cystic fibrosis mutation spectra in European populations.

Eur J Hum Genet 2003 May;11(5):385-94

Unitat de Biologia Evolutiva, Facultat de Ciències de la Salut i de la Vida, Universitat Pompeu Fabra, Barcelona, Catalonia, Spain.

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http://dx.doi.org/10.1038/sj.ejhg.5200970DOI Listing
May 2003

Dynamics of CAG repeat loci revealed by the analysis of their variability.

Hum Mutat 2003 Jan;21(1):61-70

Unitat de Biologia Evolutiva, Facultat de Ciències de la Salut i de la Vida, Universitat Pompeu Fabra, Barcelona, Spain.

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http://dx.doi.org/10.1002/humu.10151DOI Listing
January 2003