Publications



Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease.
Nat Genet 2017 Sep 17;49(9):1373-1384. Epub 2017 Jul 17.
Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.

Large Perivascular Spaces Visible on Magnetic Resonance Imaging, Cerebral Small Vessel Disease Progression, and Risk of Dementia: The Age, Gene/Environment Susceptibility-Reykjavik Study.
JAMA Neurol 2017 Sep;74(9):1105-1112
Intramural Research Program, Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Bethesda, Maryland.

Coronary Artery Bypass Graft Surgery and Dementia Risk in the Cardiovascular Health Study.
Alzheimer Dis Assoc Disord 2017 Apr-Jun;31(2):120-127
*Institute of Health Research, University of Exeter Medical School, Exeter †School of Psychology, Cardiff University, Cardiff ‡Clinical Trial Service Unit and Epidemiological Studies Unit, University of Oxford, Oxford, UK §Department of Health Science, Brigham Young University, Provo, UT Departments of ∥Epidemiology **Neurology, University of Washington, Seattle, WA Departments of ¶Epidemiology #Neurology and Psychiatry, University of Pittsburgh, Pittsburgh, PA.

Space and location of cerebral microbleeds, cognitive decline, and dementia in the community.
Neurology 2017 May 3;88(22):2089-2097. Epub 2017 May 3.
From the Laboratory of Epidemiology and Population Sciences (J.D., O.M., L.J.L.), National Institute on Aging, NIH, Bethesda, MD; Icelandic Heart Association (S.S., G.E., O.K., V.G.), Kopavogur; Faculty of Medicine (P.V.J., V.G.), University of Iceland, Reykjavik; Department of Psychiatry and Neurology (O.L.L.), University of Pittsburgh, Pennsylvania; and Department of Radiology (M.A.v.B.), Leiden University Medical Center, the Netherlands.


Association of Brain Amyloid-β With Slow Gait in Elderly Individuals Without Dementia: Influence of Cognition and Apolipoprotein E ε4 Genotype.
JAMA Neurol 2017 Jan;74(1):82-90
Alzheimer's Disease Research Center, University of Pittsburgh, Pittsburgh, Pennsylvania4Department of Neurology, University of Pittsburgh, Pittsburgh, Pennsylvania.

Neuropathological and genetic correlates of survival and dementia onset in synucleinopathies: a retrospective analysis.
Lancet Neurol 2017 Jan;16(1):55-65
Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, Morris K Udall Parkinson's Disease Center Of Excellence, Institute on Aging, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.

Novel genetic loci associated with hippocampal volume.
Nat Commun 2017 Jan 18;8:13624. Epub 2017 Jan 18.
Department of Epidemiology, Erasmus University Medical Center, 3015 CE Rotterdam, The Netherlands.

Novel genetic loci underlying human intracranial volume identified through genome-wide association.
Nat Neurosci 2016 Dec 3;19(12):1569-1582. Epub 2016 Oct 3.
Imaging Genetics Center, USC Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of University of Southern California, Los Angeles, California, USA.


Slow gait, white matter characteristics, and prior 10-year interleukin-6 levels in older adults.
Neurology 2016 Nov 12;87(19):1993-1999. Epub 2016 Oct 12.
From the Division of Geriatric Medicine and Gerontology, Department of Medicine (N.K.N.), Department of Neurology (O.L.L.) and the Pittsburgh Alzheimer's Disease Research Center (O.L.L., N.K.N.), University of Pittsburgh School of Medicine, and Department of Epidemiology, Graduate School of Public Health (R.M.B., G.L., A.B.N., C.R.), University of Pittsburgh, PA; Sticht Center on Aging (S.K.), Wake Forest School of Medicine, Winston-Salem, NC; Department of Psychiatry (K.Y.), University of California at San Francisco; and the Longitudinal Studies Section (S.A.S.), Translational Gerontology Branch, National Institute on Aging, Baltimore, MD.





Fetuin-A and risk of coronary heart disease: A Mendelian randomization analysis and a pooled analysis of AHSG genetic variants in 7 prospective studies.
Atherosclerosis 2015 Nov 5;243(1):44-52. Epub 2015 Sep 5.
Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.





Genome-wide studies of verbal declarative memory in nondemented older people: the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium.
Biol Psychiatry 2015 Apr 25;77(8):749-63. Epub 2014 Nov 25.
Department of Medicine and Neurology, University of Mississippi Medical Center, Jackson, Mississippi.

Association of Alzheimer's disease GWAS loci with MRI markers of brain aging.
Neurobiol Aging 2015 Apr 6;36(4):1765.e7-1765.e16. Epub 2015 Jan 6.
INSERM U897, University of Bordeaux, Bordeaux, France; University of Bordeaux, Bordeaux, FranceINSERM U897, University of Bordeaux, Bordeaux, France; Department of Neurology, Boston University School of Medicine, Boston, MA, USA; Department of Neurology, Bordeaux University Hospital, Bordeaux, France. Electronic address:

Rarity of the Alzheimer disease-protective APP A673T variant in the United States.
JAMA Neurol 2015 Feb;72(2):209-16
Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia.

Physical activity, body mass index, and brain atrophy in Alzheimer's disease.
Neurobiol Aging 2015 Jan 27;36 Suppl 1:S194-S202. Epub 2014 Aug 27.
Imaging Genetics Center, and Departments of Neurology, Psychiatry, Pediatrics, Engineering, Radiology, and Ophthalmology, Keck USC School of Medicine, University of Southern California, Los Angeles, CA.

Effects of multiple genetic loci on age at onset in late-onset Alzheimer disease: a genome-wide association study.
JAMA Neurol 2014 Nov;71(11):1394-404
Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois.

Amyloid, neurodegeneration, and small vessel disease as predictors of dementia in the oldest-old.
Neurology 2014 Nov 10;83(20):1804-11. Epub 2014 Oct 10.
From the Departments of Neurology (O.L.L., J.T.B., B.S., M.I., E.M.), Psychiatry (O.L.L., W.E.K., J.T.B., H.J.A.), Radiology (C.M., R.L.C., J.P., A.C.), Pharmaceutical Sciences (C.M.), Psychology (J.T.B.), Biostatistics (L.W.), and Epidemiology, Graduate School of Public Health (L.H.K.), University of Pittsburgh, School of Medicine, PA; and Department of Neurology (S.T.D.), University of Virginia School of Medicine, Charlottesville.

Erratum to "Exploratory analysis of seven Alzheimer's disease genes: disease progression" [Neurobiol. Aging 34 (2013) 1310.e1-1310.e7].
Neurobiol Aging 2014 Nov 17;35(11):2661. Epub 2014 Sep 17.
Memory Clinic of Fundació ACE, Institut Català de Neurociències Aplicades, Barcelona, Spain; Hospital Universitari Vall d'Hebron - Institut de Recerca, Universitat Autònoma de Barcelona (VHIR-UAB), Barcelona, Spain.

Regular fish consumption and age-related brain gray matter loss.
Am J Prev Med 2014 Oct 29;47(4):444-51. Epub 2014 Jul 29.
Department of Psychology, University of Pittsburgh, Pittsburgh, Pennsylvania; Department of Neurology, University of Pittsburgh, Pittsburgh, Pennsylvania; Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania. Electronic address:

Psychotic Alzheimer's disease is associated with gender-specific tau phosphorylation abnormalities.
Neurobiol Aging 2014 Sep 6;35(9):2021-8. Epub 2014 Mar 6.
The Litwin-Zucker Research Center for the Study of Alzheimer's Disease, The Feinstein Institute for Medical Research, Manhasset, NY, USA; Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA; Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA; VISN Q2 4 Mental Illness Research, Education and Clinical Center (MIRECC), VA Pittsburgh Healthcare System, Pittsburgh, PA, USA.

Vitamin D and the risk of dementia and Alzheimer disease.
Neurology 2014 Sep 6;83(10):920-8. Epub 2014 Aug 6.
From the University of Exeter Medical School (T.J.L., W.E.H., I.A.L., K.K., M.S., D.J.L.), Exeter, UK; Department of Internal Medicine and Geriatrics (C.A., O.B.), Angers University Hospital, Angers, France; Herbert Wertheim College of Medicine (P.H.M.C.), Florida International University, Miami; Mailman School of Public Health (L.F.), Columbia University, New York; Kidney Research Institute, Division of Nephrology (B.R.K.), University of Washington, Seattle; Departments of Epidemiology (L.H.K.) and Neurology and Psychiatry (O.L.L.), University of Pittsburgh, PA; Division of General Medicine (K.M.L.), Veterans Affairs Ann Arbor Center for Clinical Management Research, Ann Arbor, MI; and the Institute for Social Research and the Institute for Healthcare Policy and Innovation (K.M.L.), University of Michigan, Ann Arbor.

Effects of problem solving therapy on mental health outcomes in family caregivers of persons with a new diagnosis of mild cognitive impairment or early dementia: a randomized controlled trial.
Am J Geriatr Psychiatry 2014 Aug 8;22(8):771-81. Epub 2013 Oct 8.
Departments of Psychiatry, Biostatistics, Epidemiology, Psychology and Clinical and Translational Science, The University of Pittsburgh Schools of Medicine and Public Health, Pittsburgh, PA.

Investigation of an amyloid precursor protein protective mutation (A673T) in a North American case-control sample of late-onset Alzheimer's disease.
Neurobiol Aging 2014 Jul 23;35(7):1779.e15-6. Epub 2014 Jan 23.
Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address:

Joint effect of mid- and late-life blood pressure on the brain: the AGES-Reykjavik study.
Neurology 2014 Jun 4;82(24):2187-95. Epub 2014 Jun 4.
From the Laboratory of Epidemiology and Population Sciences (M.M., T.B.H., L.J.L.), Intramural Research Program, National Institute on Aging, Bethesda, MD; the Departments of Gerontology and Geriatrics (M.M.) and Radiology (M.v.B.), Leiden University Medical Center; Icelandic Heart Association (S.S., O.K., T.A., V.G.), Kopovagur; the Departments of Neurology & Radiology (O.K.) and Geriatrics (P.V.J.), Landspitali National University Hospital, Reykjavik, Iceland; the Department of Neurology (O.L.L.), University of Pittsburgh, PA; and the Faculty of Medicine (P.V.J.), University of Iceland, Reykjavik.


Pulse wave velocity is associated with β-amyloid deposition in the brains of very elderly adults.
Neurology 2013 Nov 16;81(19):1711-8. Epub 2013 Oct 16.
From the Department of Epidemiology, Graduate School of Public Health (T.M.H., L.H.K., E.J.M.B.-M., R.H.M.), and the Departments of Neurology (E.M.M., B.E.S., O.L.L.), Psychiatry (W.E.K., H.J.A., A.D.C.), and Radiology (C.A.M.), School of Medicine, University of Pittsburgh, PA; and the Office of the Dean and Department of Neurology (S.T.D.), School of Medicine, University of Virginia, Charlottesville.








Hyperphosphorylated tau is elevated in Alzheimer's disease with psychosis.
J Alzheimers Dis 2014 ;39(4):759-73
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA VISN 4 Mental Illness Research, Education and Clinical Center, VA Pittsburgh Healthcare System, Pittsburgh, PA, USA Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

Gene-wide analysis detects two new susceptibility genes for Alzheimer's disease.
PLoS One 2014 12;9(6):e94661. Epub 2014 Jun 12.
Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom.

A rare duplication on chromosome 16p11.2 is identified in patients with psychosis in Alzheimer's disease.
PLoS One 2014 7;9(11):e111462. Epub 2014 Nov 7.
Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America; Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.


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