Oscar Franzen

Oscar Franzen

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Oscar Franzen

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PanglaoDB: a web server for exploration of mouse and human single-cell RNA sequencing data.

Database (Oxford) 2019 01;2019

Integrated Cardio Metabolic Centre (ICMC), Department of Medicine, Karolinska Institutet, Novum SE Huddinge, Sweden.

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https://academic.oup.com/database/article/doi/10.1093/databa
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http://dx.doi.org/10.1093/database/baz046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450036PMC
January 2019

GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes.

Authors:
Nora Franceschini Claudia Giambartolomei Paul S de Vries Chris Finan Joshua C Bis Rachael P Huntley Ruth C Lovering Salman M Tajuddin Thomas W Winkler Misa Graff Maryam Kavousi Caroline Dale Albert V Smith Edith Hofer Elisabeth M van Leeuwen Ilja M Nolte Lingyi Lu Markus Scholz Muralidharan Sargurupremraj Niina Pitkänen Oscar Franzén Peter K Joshi Raymond Noordam Riccardo E Marioni Shih-Jen Hwang Solomon K Musani Ulf Schminke Walter Palmas Aaron Isaacs Adolfo Correa Alan B Zonderman Albert Hofman Alexander Teumer Amanda J Cox André G Uitterlinden Andrew Wong Andries J Smit Anne B Newman Annie Britton Arno Ruusalepp Bengt Sennblad Bo Hedblad Bogdan Pasaniuc Brenda W Penninx Carl D Langefeld Christina L Wassel Christophe Tzourio Cristiano Fava Damiano Baldassarre Daniel H O'Leary Daniel Teupser Diana Kuh Elena Tremoli Elmo Mannarino Enzo Grossi Eric Boerwinkle Eric E Schadt Erik Ingelsson Fabrizio Veglia Fernando Rivadeneira Frank Beutner Ganesh Chauhan Gerardo Heiss Harold Snieder Harry Campbell Henry Völzke Hugh S Markus Ian J Deary J Wouter Jukema Jacqueline de Graaf Jacqueline Price Janne Pott Jemma C Hopewell Jingjing Liang Joachim Thiery Jorgen Engmann Karl Gertow Kenneth Rice Kent D Taylor Klodian Dhana Lambertus A L M Kiemeney Lars Lind Laura M Raffield Lenore J Launer Lesca M Holdt Marcus Dörr Martin Dichgans Matthew Traylor Matthias Sitzer Meena Kumari Mika Kivimaki Mike A Nalls Olle Melander Olli Raitakari Oscar H Franco Oscar L Rueda-Ochoa Panos Roussos Peter H Whincup Philippe Amouyel Philippe Giral Pramod Anugu Quenna Wong Rainer Malik Rainer Rauramaa Ralph Burkhardt Rebecca Hardy Reinhold Schmidt Renée de Mutsert Richard W Morris Rona J Strawbridge S Goya Wannamethee Sara Hägg Sonia Shah Stela McLachlan Stella Trompet Sudha Seshadri Sudhir Kurl Susan R Heckbert Susan Ring Tamara B Harris Terho Lehtimäki Tessel E Galesloot Tina Shah Ulf de Faire Vincent Plagnol Wayne D Rosamond Wendy Post Xiaofeng Zhu Xiaoling Zhang Xiuqing Guo Yasaman Saba Abbas Dehghan Adrie Seldenrijk Alanna C Morrison Anders Hamsten Bruce M Psaty Cornelia M van Duijn Deborah A Lawlor Dennis O Mook-Kanamori Donald W Bowden Helena Schmidt James F Wilson James G Wilson Jerome I Rotter Joanna M Wardlaw John Deanfield Julian Halcox Leo-Pekka Lyytikäinen Markus Loeffler Michele K Evans Stéphanie Debette Steve E Humphries Uwe Völker Vilmundur Gudnason Aroon D Hingorani Johan L M Björkegren Juan P Casas Christopher J O'Donnell

Nat Commun 2018 12 3;9(1):5141. Epub 2018 Dec 3.

Intramural Administration Management Branch, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD, 20892, USA.

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http://dx.doi.org/10.1038/s41467-018-07340-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277418PMC
December 2018

CD90 Identifies Adventitial Mesenchymal Progenitor Cells in Adult Human Medium- and Large-Sized Arteries.

Stem Cell Reports 2018 07 28;11(1):242-257. Epub 2018 Jun 28.

The Zena and Michael A. Wiener Cardiovascular Institute and Cardiovascular Research Center, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1030, New York, NY 10029, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2018.06.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6067150PMC
July 2018

A novel high-resolution multilocus sequence typing of Giardia intestinalis Assemblage A isolates reveals zoonotic transmission, clonal outbreaks and recombination.

Infect Genet Evol 2018 06 10;60:7-16. Epub 2018 Feb 10.

Department of Cell and Molecular Biology, BMC, Box 596, Uppsala University, SE-751 24 Uppsala, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.meegid.2018.02.012DOI Listing
June 2018

Large-Scale Identification of Common Trait and Disease Variants Affecting Gene Expression.

Am J Hum Genet 2017 Jun 25;100(6):885-894. Epub 2017 May 25.

Department of Psychiatry and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Genetics and Genomic Sciences and Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Mental Illness Research Education and Clinical Center, James J. Peters VA Medical Center, Bronx, New York, NY 10468, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2017.04.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5474225PMC
June 2017

Regulation of PfEMP1-VAR2CSA translation by a Plasmodium translation-enhancing factor.

Nat Microbiol 2017 May 8;2:17068. Epub 2017 May 8.

Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institutet, Box 280, Nobels väg 16, 171 77 Stockholm, Sweden.

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http://dx.doi.org/10.1038/nmicrobiol.2017.68DOI Listing
May 2017

Poliovirus Receptor-Related 2: A Cholesterol-Responsive Gene Affecting Atherosclerosis Development by Modulating Leukocyte Migration.

Arterioscler Thromb Vasc Biol 2017 Mar 5;37(3):534-542. Epub 2017 Jan 5.

From the Division of Vascular Biology, Department of Medical Biochemistry and Biophysics (A.R., H.G., C.M., H.F.A., H.A.T., J.L.M.B., E.F., J.S.) and Unit of Computational Medicine, Department of Medicine (M.-M.S.), Karolinska Institutet, Stockholm, Sweden; Department of Genetics and Genomic Sciences, Institute of Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY (O.F., J.L.M.B.); and Department of Molecular Genetics and Microbiology, Stony Brook University, New York, NY (S.M.).

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http://dx.doi.org/10.1161/ATVBAHA.116.308715DOI Listing
March 2017

Systematic Evaluation of Pleiotropy Identifies 6 Further Loci Associated With Coronary Artery Disease.

Authors:
Thomas R Webb Jeanette Erdmann Kathleen E Stirrups Nathan O Stitziel Nicholas G D Masca Henning Jansen Stavroula Kanoni Christopher P Nelson Paola G Ferrario Inke R König John D Eicher Andrew D Johnson Stephen E Hamby Christer Betsholtz Arno Ruusalepp Oscar Franzén Eric E Schadt Johan L M Björkegren Peter E Weeke Paul L Auer Ursula M Schick Yingchang Lu He Zhang Marie-Pierre Dube Anuj Goel Martin Farrall Gina M Peloso Hong-Hee Won Ron Do Erik van Iperen Jochen Kruppa Anubha Mahajan Robert A Scott Christina Willenborg Peter S Braund Julian C van Capelleveen Alex S F Doney Louise A Donnelly Rosanna Asselta Pier A Merlini Stefano Duga Nicola Marziliano Josh C Denny Christian Shaffer Nour Eddine El-Mokhtari Andre Franke Stefanie Heilmann Christian Hengstenberg Per Hoffmann Oddgeir L Holmen Kristian Hveem Jan-Håkan Jansson Karl-Heinz Jöckel Thorsten Kessler Jennifer Kriebel Karl L Laugwitz Eirini Marouli Nicola Martinelli Mark I McCarthy Natalie R Van Zuydam Christa Meisinger Tõnu Esko Evelin Mihailov Stefan A Escher Maris Alver Susanne Moebus Andrew D Morris Jarma Virtamo Majid Nikpay Oliviero Olivieri Sylvie Provost Alaa AlQarawi Neil R Robertson Karen O Akinsansya Dermot F Reilly Thomas F Vogt Wu Yin Folkert W Asselbergs Charles Kooperberg Rebecca D Jackson Eli Stahl Martina Müller-Nurasyid Konstantin Strauch Tibor V Varga Melanie Waldenberger Lingyao Zeng Rajiv Chowdhury Veikko Salomaa Ian Ford J Wouter Jukema Philippe Amouyel Jukka Kontto Børge G Nordestgaard Jean Ferrières Danish Saleheen Naveed Sattar Praveen Surendran Aline Wagner Robin Young Joanna M M Howson Adam S Butterworth John Danesh Diego Ardissino Erwin P Bottinger Raimund Erbel Paul W Franks Domenico Girelli Alistair S Hall G Kees Hovingh Adnan Kastrati Wolfgang Lieb Thomas Meitinger William E Kraus Svati H Shah Ruth McPherson Marju Orho-Melander Olle Melander Andres Metspalu Colin N A Palmer Annette Peters Daniel J Rader Muredach P Reilly Ruth J F Loos Alex P Reiner Dan M Roden Jean-Claude Tardif John R Thompson Nicholas J Wareham Hugh Watkins Cristen J Willer Nilesh J Samani Heribert Schunkert Panos Deloukas Sekar Kathiresan

J Am Coll Cardiol 2017 Feb;69(7):823-836

Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts; Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts; Department of Medicine, Harvard Medical School, Boston, Massachusetts; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts; Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts.

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http://dx.doi.org/10.1016/j.jacc.2016.11.056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5314135PMC
February 2017

Meta-Analysis of Genome-Wide Association Studies for Abdominal Aortic Aneurysm Identifies Four New Disease-Specific Risk Loci.

Authors:
Gregory T Jones Gerard Tromp Helena Kuivaniemi Solveig Gretarsdottir Annette F Baas Betti Giusti Ewa Strauss Femke N G Van't Hof Thomas R Webb Robert Erdman Marylyn D Ritchie James R Elmore Anurag Verma Sarah Pendergrass Iftikhar J Kullo Zi Ye Peggy L Peissig Omri Gottesman Shefali S Verma Jennifer Malinowski Laura J Rasmussen-Torvik Kenneth M Borthwick Diane T Smelser David R Crosslin Mariza de Andrade Evan J Ryer Catherine A McCarty Erwin P Böttinger Jennifer A Pacheco Dana C Crawford David S Carrell Glenn S Gerhard David P Franklin David J Carey Victoria L Phillips Michael J A Williams Wenhua Wei Ross Blair Andrew A Hill Thodor M Vasudevan David R Lewis Ian A Thomson Jo Krysa Geraldine B Hill Justin Roake Tony R Merriman Grzegorz Oszkinis Silvia Galora Claudia Saracini Rosanna Abbate Raffaele Pulli Carlo Pratesi Athanasios Saratzis Ana R Verissimo Suzannah Bumpstead Stephen A Badger Rachel E Clough Gillian Cockerill Hany Hafez D Julian A Scott T Simon Futers Simon P R Romaine Katherine Bridge Kathryn J Griffin Marc A Bailey Alberto Smith Matthew M Thompson Frank M van Bockxmeer Stefan E Matthiasson Gudmar Thorleifsson Unnur Thorsteinsdottir Jan D Blankensteijn Joep A W Teijink Cisca Wijmenga Jacqueline de Graaf Lambertus A Kiemeney Jes S Lindholt Anne Hughes Declan T Bradley Kathleen Stirrups Jonathan Golledge Paul E Norman Janet T Powell Steve E Humphries Stephen E Hamby Alison H Goodall Christopher P Nelson Natzi Sakalihasan Audrey Courtois Robert E Ferrell Per Eriksson Lasse Folkersen Anders Franco-Cereceda John D Eicher Andrew D Johnson Christer Betsholtz Arno Ruusalepp Oscar Franzén Eric E Schadt Johan L M Björkegren Leonard Lipovich Anne M Drolet Eric L Verhoeven Clark J Zeebregts Robert H Geelkerken Marc R van Sambeek Steven M van Sterkenburg Jean-Paul de Vries Kari Stefansson John R Thompson Paul I W de Bakker Panos Deloukas Robert D Sayers Seamus C Harrison Andre M van Rij Nilesh J Samani Matthew J Bown

Circ Res 2017 Jan 29;120(2):341-353. Epub 2016 Nov 29.

For the author affiliations, please see the Appendix.

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http://dx.doi.org/10.1161/CIRCRESAHA.116.308765DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5253231PMC
January 2017

Preservation Analysis of Macrophage Gene Coexpression Between Human and Mouse Identifies PARK2 as a Genetically Controlled Master Regulator of Oxidative Phosphorylation in Humans.

G3 (Bethesda) 2016 10 13;6(10):3361-3371. Epub 2016 Oct 13.

Sorbonne Universités, Université Pierre et Marie Curie, Paris 06, Institut National de la Santé et de la Recherche Médicale, Unité Mixte de Recherche en Santé 1166, F-75013 Paris, France Institute for Cardiometabolism and Nutrition, F-75013 Paris, France

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http://dx.doi.org/10.1534/g3.116.033894DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5068955PMC
October 2016

Cardiometabolic risk loci share downstream cis- and trans-gene regulation across tissues and diseases.

Science 2016 Aug;353(6301):827-30

Department of Genetics and Genomic Sciences, The Icahn Institute for Genomics and Multiscale Biology Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York , NY 10029, USA. Clinical Gene Networks AB, Jungfrugatan 10, 114 44 Stockholm, Sweden. Department of Pathophysiology, Institute of Biomedicine and Translation Medicine, University of Tartu, Biomeedikum, Ravila 19, 50411, Tartu, Estonia. Division of Vascular Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Scheeles Väg 2, 171 77 Stockholm, Sweden.

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http://dx.doi.org/10.1126/science.aad6970DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5534139PMC
August 2016

Cross-Tissue Regulatory Gene Networks in Coronary Artery Disease.

Cell Syst 2016 03 3;2(3):196-208. Epub 2016 Mar 3.

Cardiovascular Genomics Group, Division of Vascular Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 171 77 Stockholm, Sweden; Department of Physiology, Institute of Biomedicine and Translation Medicine, University of Tartu, 51014 Tartu, Estonia; Clinical Gene Networks AB, 114 44 Stockholm, Sweden; Department of Genetics & Genomic Sciences, Institute of Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Cardiovascular Institute, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cels.2016.02.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4855300PMC
March 2016

Improved OTU-picking using long-read 16S rRNA gene amplicon sequencing and generic hierarchical clustering.

Microbiome 2015 Oct 5;3:43. Epub 2015 Oct 5.

Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

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http://dx.doi.org/10.1186/s40168-015-0105-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4593230PMC
October 2015

Erratum to: Improved OTU-picking using long-read 16S rRNA gene amplicon sequencing and generic hierarchical clustering.

Microbiome 2015 Oct 28;3:57. Epub 2015 Oct 28.

Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

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http://dx.doi.org/10.1186/s40168-015-0123-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4624701PMC
October 2015

Comparative genomic analyses of freshly isolated Giardia intestinalis assemblage A isolates.

BMC Genomics 2015 Sep 15;16:697. Epub 2015 Sep 15.

Department of Cell and Molecular Biology, Science for Life Laboratory, BMC, Uppsala University, Box 596, SE-751 24, Uppsala, Sweden.

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http://dx.doi.org/10.1186/s12864-015-1893-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4570179PMC
September 2015

Complex polymorphisms in the Plasmodium falciparum multidrug resistance protein 2 gene and its contribution to antimalarial response.

Antimicrob Agents Chemother 2014 Dec 29;58(12):7390-7. Epub 2014 Sep 29.

Drug Resistance and Pharmacogenetics, Center for Biodiversity, Functional and Integrative Genomics, Faculdade de Ciências, Universidade de Lisboa, Lisbon, Portugal Harpur College of Arts and Sciences, Binghamton University, The State University of New York, Binghamton, New York, USA Division of Pharmacogenetics, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1128/AAC.03337-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4249497PMC
December 2014

A particular set of small non-coding RNAs is bound to the distinctive Argonaute protein of Trypanosoma cruzi: insights from RNA-interference deficient organisms.

Gene 2014 Apr 23;538(2):379-84. Epub 2014 Jan 23.

Laboratory of Functional Genomics, Institut Pasteur of Montevideo, Montevideo, Uruguay; Department of Medicine, Hospital de Clínicas, Montevideo, Uruguay. Electronic address:

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http://dx.doi.org/10.1016/j.gene.2014.01.023DOI Listing
April 2014

Transcriptome profiling of Giardia intestinalis using strand-specific RNA-seq.

PLoS Comput Biol 2013 28;9(3):e1003000. Epub 2013 Mar 28.

Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1371/journal.pcbi.1003000DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3610916PMC
November 2013

Multiple mitochondrial introgression events and heteroplasmy in trypanosoma cruzi revealed by maxicircle MLST and next generation sequencing.

PLoS Negl Trop Dis 2012 10;6(4):e1584. Epub 2012 Apr 10.

Department of Pathogen Molecular Biology, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom.

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http://dx.doi.org/10.1371/journal.pntd.0001584DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3323513PMC
August 2012

The short non-coding transcriptome of the protozoan parasite Trypanosoma cruzi.

PLoS Negl Trop Dis 2011 Aug 30;5(8):e1283. Epub 2011 Aug 30.

Science for Life Laboratory, Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1371/journal.pntd.0001283DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3166047PMC
August 2011

Shotgun sequencing analysis of Trypanosoma cruzi I Sylvio X10/1 and comparison with T. cruzi VI CL Brener.

PLoS Negl Trop Dis 2011 Mar 8;5(3):e984. Epub 2011 Mar 8.

Science for Life Laboratory, Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1371/journal.pntd.0000984DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3050914PMC
March 2011

Two pools of vesicles associated with the presynaptic cytosolic projection in Drosophila neuromuscular junctions.

J Struct Biol 2010 Dec 1;172(3):389-94. Epub 2010 Aug 1.

Department of Neuroscience, DBRM, Karolinska Institutet, 17177 Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.jsb.2010.07.007DOI Listing
December 2010