Osamu Takeuchi

Osamu Takeuchi

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Osamu Takeuchi

Publications by authors named "Osamu Takeuchi"

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Live-Cell Imaging of Protein Degradation Utilizing Designed Protein-Tag Mutant and Fluorescent Probe with Turn-Off Switch.

Bioconjug Chem 2020 Mar 9;31(3):577-583. Epub 2020 Jan 9.

Department of Medical Chemistry, Graduate School of Medicine, Kyoto University, Kyoto 606-8501, Japan.

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http://dx.doi.org/10.1021/acs.bioconjchem.9b00696DOI Listing
March 2020

Prexasertib increases the sensitivity of pancreatic cancer cells to gemcitabine and S‑1.

Oncol Rep 2020 Feb 28;43(2):689-699. Epub 2019 Nov 28.

Center for Education and Research on Clinical Pharmacy, Showa Pharmaceutical University, Tokyo 194‑8543, Japan.

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http://dx.doi.org/10.3892/or.2019.7421DOI Listing
February 2020

Codon bias confers stability to human mRNAs.

EMBO Rep 2019 11 3;20(11):e48220. Epub 2019 Sep 3.

Department of Medical Chemistry, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

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http://dx.doi.org/10.15252/embr.201948220DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6831995PMC
November 2019

Continuous Heteroepitaxy of Two-Dimensional Heterostructures Based on Layered Chalcogenides.

ACS Nano 2019 Jul 20;13(7):7527-7535. Epub 2019 Jun 20.

Department of Physics , Tokyo Metropolitan University , Hachioji, Tokyo 192-0397 , Japan.

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http://dx.doi.org/10.1021/acsnano.8b07991DOI Listing
July 2019

Post-transcriptional control of immune responses and its potential application.

Clin Transl Immunology 2019 17;8(6):e1063. Epub 2019 Jun 17.

Department of Medical Chemistry Graduate School of Medicine Kyoto University Kyoto Japan.

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http://dx.doi.org/10.1002/cti2.1063DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6580065PMC
June 2019

RNA binding proteins in the control of autoimmune diseases.

Immunol Med 2019 Jun 26;42(2):53-64. Epub 2019 Aug 26.

Department of Medical Chemistry, Graduate School of Medicine, Kyoto University , Kyoto , Japan.

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http://dx.doi.org/10.1080/25785826.2019.1655192DOI Listing
June 2019

Individualized treatment based on CYP3A5 single-nucleotide polymorphisms with tacrolimus in ulcerative colitis.

Intest Res 2019 Apr 7;17(2):218-226. Epub 2019 Feb 7.

Center for Advanced IBD Research and Treatment, Department of Research, Kitasato University Kitasato Institute Hospital, Tokyo, Japan.

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http://dx.doi.org/10.5217/ir.2018.00117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6505090PMC
April 2019

Surface-mediated spin dynamics probed by optical-pump-probe scanning tunneling microscopy.

Phys Chem Chem Phys 2019 Apr;21(14):7256-7260

Faculty of Pure and Applied Sciences, University of Tsukuba, Tsukuba, Ibaraki 305-8573, Japan.

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http://xlink.rsc.org/?DOI=C8CP07786J
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http://dx.doi.org/10.1039/c8cp07786jDOI Listing
April 2019

Hassall's corpuscles with cellular-senescence features maintain IFNα production through neutrophils and pDC activation in the thymus.

Int Immunol 2019 03;31(3):127-139

Department of Immunology and Cell Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

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http://dx.doi.org/10.1093/intimm/dxy073DOI Listing
March 2019

Evolution of local conductance pathways in a single-molecule junction studied using the three-dimensional dynamic probe method.

Nanoscale 2019 Mar;11(13):5951-5959

Faculty of Pure and Applied Sciences, University of Tsukuba, Tsukuba 305-8571, Japan.

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http://dx.doi.org/10.1039/c9nr00717bDOI Listing
March 2019

Mechanisms of metformin's anti‑tumor activity against gemcitabine‑resistant pancreatic adenocarcinoma.

Int J Oncol 2019 Feb 10;54(2):764-772. Epub 2018 Dec 10.

Department of Surgery, Keio University School of Medicine, Tokyo 160‑8582, Japan.

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http://dx.doi.org/10.3892/ijo.2018.4662DOI Listing
February 2019

A Simple 1-Day Colon Capsule Endoscopy Procedure Demonstrated to be a Highly Acceptable Monitoring Tool for Ulcerative Colitis.

Inflamm Bowel Dis 2018 10;24(11):2404-2412

Center for Advanced IBD Research and Treatment, Kitasato University Kitasato Institute Hospital, Tokyo, Japan.

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http://dx.doi.org/10.1093/ibd/izy125DOI Listing
October 2018

Post-transcriptional regulation of immune responses by RNA binding proteins.

Proc Jpn Acad Ser B Phys Biol Sci 2018 ;94(6):248-258

Laboratory of Infection and Prevention, Institute for Frontier Life and Medical Sciences, Kyoto University.

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http://dx.doi.org/10.2183/pjab.94.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6085518PMC
October 2018

Translation of Hepatitis A Virus IRES Is Upregulated by a Hepatic Cell-Specific Factor.

Front Genet 2018 10;9:307. Epub 2018 Aug 10.

Laboratory of Biochemistry, Graduate School of Pharmaceutical Sciences, Kindai University, Osaka, Japan.

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http://dx.doi.org/10.3389/fgene.2018.00307DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6095998PMC
August 2018

Pulmonary Regnase-1 orchestrates the interplay of epithelium and adaptive immune systems to protect against pneumonia.

Mucosal Immunol 2018 07 25;11(4):1203-1218. Epub 2018 Apr 25.

Laboratory of Infection and Prevention, Department of Virus Research, Institute for Frontier Life and Medical Sciences, Kyoto University, 253 Shogoin Kawara-cho, Sakyo-ku, Kyoto, 606-8507, Japan.

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http://dx.doi.org/10.1038/s41385-018-0024-5DOI Listing
July 2018

The effect of nitrogen lone-pair interaction on the conduction in a single-molecule junction with amine-Au bonding.

Sci Rep 2018 Mar 27;8(1):5222. Epub 2018 Mar 27.

Faculty of Pure and Applied Sciences, University of Tsukuba, Tsukuba, 305-8571, Japan.

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http://dx.doi.org/10.1038/s41598-018-22893-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5869721PMC
March 2018

Akirin2-Mediated Transcriptional Control by Recruiting SWI/SNF Complex in B Cells.

Crit Rev Immunol 2016 ;36(5):395-406

Laboratory of Infection and Prevention, Institute for Frontier Life and Medical Sciences, Kyoto University, 53 Shogoin, Kawara-Cho, Sakyo-Ku, Kyoto 606-8507, Japan; AMED-CREST, Japan Agency for Medical Research and Development, Kyoto 606-8501, Japan.

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http://dx.doi.org/10.1615/CritRevImmunol.2017019629DOI Listing
January 2018

Endonuclease Regnase-1/Monocyte chemotactic protein-1-induced protein-1 (MCPIP1) in controlling immune responses and beyond.

Authors:
Osamu Takeuchi

Wiley Interdiscip Rev RNA 2018 01 20;9(1). Epub 2017 Sep 20.

Laboratory of Infection and Prevention, Institute for Frontier Life and Medical Sciences, Kyoto University, AMED-CREST, AMED, Kyoto, Japan.

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http://dx.doi.org/10.1002/wrna.1449DOI Listing
January 2018

Regnase-1 and Roquin Nonredundantly Regulate Th1 Differentiation Causing Cardiac Inflammation and Fibrosis.

J Immunol 2017 12 10;199(12):4066-4077. Epub 2017 Nov 10.

Laboratory of Infection and Prevention, Department of Virus Research, Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto 606-8507, Japan;

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http://www.jimmunol.org/lookup/doi/10.4049/jimmunol.1701211
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http://dx.doi.org/10.4049/jimmunol.1701211DOI Listing
December 2017

NSD3 keeps IRF3 active.

J Exp Med 2017 12 20;214(12):3475-3476. Epub 2017 Nov 20.

Laboratory of Infection and Prevention, Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto, Japan; Japan Agency for Medical Research and Development-Core Research for Evolutional Medical Science and Technology (AMED-CREST), Tokyo, Japan.

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http://dx.doi.org/10.1084/jem.20171980DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5716047PMC
December 2017

Regnase-1 Is an Endoribonuclease Essential for the Maintenance of Immune Homeostasis.

J Interferon Cytokine Res 2017 05;37(5):220-229

1 Laboratory of Infection and Prevention, Institute for Frontier Life and Medical Sciences, Kyoto University , Kyoto, Japan .

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http://dx.doi.org/10.1089/jir.2017.0001DOI Listing
May 2017

Regnase-1 Maintains Iron Homeostasis via the Degradation of Transferrin Receptor 1 and Prolyl-Hydroxylase-Domain-Containing Protein 3 mRNAs.

Cell Rep 2017 05;19(8):1614-1630

Laboratory of Infection and Prevention, Department of Virus Research, Institute for Frontier Life and Medical Sciences, Kyoto University, 53 Shogoin Kawara-cho, Sakyo-ku, Kyoto 606-8507, Japan; Agency for Medical Research and Development-Core Research for Evolutional Medical Science and Technology (AMED-CREST), Japan Agency for Medical Research and Development, Tokyo 100-0004, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.05.009DOI Listing
May 2017

Evaluation of Suppressive Effects of Tranilast on the Invasion/Metastasis Mechanism in a Murine Pancreatic Cancer Cell Line.

Pancreas 2017 04;46(4):567-574

From the *Department of Surgery, Kitasato Institute Hospital; †Department of Surgery, Keio University School of Medicine; ‡Biomedical Laboratory, Kitasato Institute Hospital; and §Department of Pharmacy, Center for Clinical Pharmacy and Clinical Science, Kitasato University, Tokyo, Japan.

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http://dx.doi.org/10.1097/MPA.0000000000000779DOI Listing
April 2017

Translational control of mRNAs by 3'-Untranslated region binding proteins.

BMB Rep 2017 Apr;50(4):194-200

Laboratory of Infection and Prevention, Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto 606-8507, Japan.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5437963PMC
http://dx.doi.org/10.5483/bmbrep.2017.50.4.040DOI Listing
April 2017

Pathogen recognition and Toll-like receptor targeted therapeutics in innate immune cells.

Int Rev Immunol 2017 03 6;36(2):57-73. Epub 2017 Jan 6.

a Laboratory of Infection and Prevention, Institute for Virus Research, Kyoto University , Kawara-Cho, Sakyo-Ku, Kyoto , Japan.

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http://dx.doi.org/10.1080/08830185.2016.1261318DOI Listing
March 2017

Mitochondrial damage elicits a TCDD-inducible poly(ADP-ribose) polymerase-mediated antiviral response.

Proc Natl Acad Sci U S A 2017 03 17;114(10):2681-2686. Epub 2017 Feb 17.

Division of Inflammation Biology, Institute for Enzyme Research, Tokushima University, Tokushima 770-8503, Japan;

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http://dx.doi.org/10.1073/pnas.1621508114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5347618PMC
March 2017

Sex Differences in mRNA Expression of Reduced Folate Carrier-1, Folypolyformyl Glutamate Synthase, and γ-Glutamyl Hydrolase in a Healthy Japanese Population.

J Clin Pharmacol 2016 12 18;56(12):1563-1569. Epub 2016 May 18.

Division for Evaluation and Analysis of Drug Information, Faculty of Pharmacy, Keio University, Minato-ku, Tokyo, Japan.

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http://doi.wiley.com/10.1002/jcph.760
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http://dx.doi.org/10.1002/jcph.760DOI Listing
December 2016

Genetic polymorphisms of enzyme proteins and transporters related to methotrexate response and pharmacokinetics in a Japanese population.

J Pharm Health Care Sci 2016 9;2:35. Epub 2016 Dec 9.

Division for Evaluation and Analysis of Drug Information, Faculty of Pharmacy, Keio University, 1-5-30 Shibakoen, Minato-ku, Tokyo, 105-8512 Japan.

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http://dx.doi.org/10.1186/s40780-016-0069-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5148839PMC
December 2016

Revealing the Conformational Dynamics in a Single-Molecule Junction by Site- and Angle-Resolved Dynamic Probe Method.

ACS Nano 2016 12 2;10(12):11211-11218. Epub 2016 Dec 2.

Faculty of Pure and Applied Sciences, University of Tsukuba , Tsukuba 305-8571, Japan.

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http://pubs.acs.org/doi/10.1021/acsnano.6b06278
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http://dx.doi.org/10.1021/acsnano.6b06278DOI Listing
December 2016

Flesh-eating Streptococcus pyogenes triggers the expression of receptor activator of nuclear factor-κB ligand.

Cell Microbiol 2016 10 22;18(10):1390-404. Epub 2016 Mar 22.

Laboratory of Cell and Tissue Biology, Keio University School of Medicine, Shinjuku-ku, Tokyo, 160-8582, Japan.

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http://dx.doi.org/10.1111/cmi.12581DOI Listing
October 2016

Nanoparticle-Mediated Delivery of Mitochondrial Division Inhibitor 1 to the Myocardium Protects the Heart From Ischemia-Reperfusion Injury Through Inhibition of Mitochondria Outer Membrane Permeabilization: A New Therapeutic Modality for Acute Myocardial Infarction.

J Am Heart Assoc 2016 07 22;5(7). Epub 2016 Jul 22.

Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan Department of Cardiovascular Research, Development, and Translational Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan

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http://dx.doi.org/10.1161/JAHA.116.003872DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5015412PMC
July 2016

Attractive interaction between Mn atoms on the GaAs(110) surface observed by scanning tunneling microscopy.

Nanoscale 2016 Jun;8(24):12118-22

Faculty of Pure and Applied Sciences, University of Tsukuba, Tsukuba, Ibaraki 305-8573, Japan.

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http://dx.doi.org/10.1039/c6nr02190eDOI Listing
June 2016

Inhibition of IL-1R1/MyD88 signalling promotes mesenchymal stem cell-driven tissue regeneration.

Nat Commun 2016 Mar 22;7:11051. Epub 2016 Mar 22.

WPI Immunology Frontier Research Center, Osaka University, 3-1 Yamada-oka, Suita, Osaka 565-0871, Japan.

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http://dx.doi.org/10.1038/ncomms11051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4804175PMC
March 2016

Nickel ions selectively inhibit lipopolysaccharide-induced interleukin-6 production by decreasing its mRNA stability.

PLoS One 2015 5;10(3):e0119428. Epub 2015 Mar 5.

Laboratory of Pharmacotherapy of Life-Style Related Diseases, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Miyagi, Japan.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0119428PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4351189PMC
January 2016

Microscopic basis for the band engineering of Mo1-xWxS2-based heterojunction.

Sci Rep 2015 Oct 7;5:14808. Epub 2015 Oct 7.

Faculty of Pure and Applied Sciences, University of Tsukuba, Tsukuba 305-8573, Japan.

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http://dx.doi.org/10.1038/srep14808DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4595798PMC
October 2015

Essential Function for the Nuclear Protein Akirin2 in B Cell Activation and Humoral Immune Responses.

J Immunol 2015 Jul 3;195(2):519-27. Epub 2015 Jun 3.

Laboratory of Infection and Prevention, Institute for Virus Research, Kyoto University, Kyoto 606-8507, Japan; Core Research for Engineering, Science, and Technology, Japan Science and Technology Agency, Kyoto 606-8507, Japan; and

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http://dx.doi.org/10.4049/jimmunol.1500373DOI Listing
July 2015

Regnase-1 and Roquin regulate inflammatory mRNAs.

Oncotarget 2015 Jul;6(20):17869-70

Laboratory of Infection and Prevention, Institute for Virus Research, Kyoto University, Kyoto, Japan.

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http://www.oncotarget.com/fulltext/4891
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4627220PMC
http://dx.doi.org/10.18632/oncotarget.4891DOI Listing
July 2015

Chromatin Remodeling and Transcriptional Control in Innate Immunity: Emergence of Akirin2 as a Novel Player.

Biomolecules 2015 Jul 22;5(3):1618-33. Epub 2015 Jul 22.

Laboratory of Infection and Prevention, Institute for Virus research, Kyoto University, 53 Shogoin, Kawara-Cho, Sakyo-Ku, Kyoto 606-8507, Japan.

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http://dx.doi.org/10.3390/biom5031618DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4598767PMC
July 2015

HuR keeps interferon-β mRNA stable.

Authors:
Osamu Takeuchi

Eur J Immunol 2015 May;45(5):1296-9

Laboratory of Infection and Prevention, Institute for Virus Research, Kyoto University, Kyoto, Japan.

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http://dx.doi.org/10.1002/eji.201545616DOI Listing
May 2015

Regnase-1 and Roquin Regulate a Common Element in Inflammatory mRNAs by Spatiotemporally Distinct Mechanisms.

Cell 2015 May;161(5):1058-1073

Laboratory of Infection and Prevention, Institute for Virus Research, Kyoto University, Kyoto 606-8507, Japan; CREST, JST, Kyoto 606-8507, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2015.04.029DOI Listing
May 2015

5-Azacytidine-induced protein 2 (AZI2) regulates bone mass by fine-tuning osteoclast survival.

J Biol Chem 2015 Apr 17;290(15):9377-86. Epub 2015 Feb 17.

From the Laboratory of Host Defense, World Premier International (WPI) Immunology Frontier Research Center (IFReC), Osaka University, Osaka 565-0871, the Research Institute for Microbial Diseases, Osaka University, Osaka 565-0871,

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http://www.jbc.org/content/290/15/9377.full.pdf
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http://www.jbc.org/lookup/doi/10.1074/jbc.M114.631374
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http://dx.doi.org/10.1074/jbc.M114.631374DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4392245PMC
April 2015

[Posttranscriptional control of inflammation by an RNase Regnase-1].

Authors:
Osamu Takeuchi

Nihon Yakurigaku Zasshi 2015 Mar;145(3):129-33

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http://dx.doi.org/10.1254/fpj.145.129DOI Listing
March 2015

Force measurement enabling precise analysis by dynamic force spectroscopy.

Int J Mol Sci 2012 29;13(1):453-65. Epub 2011 Dec 29.

Institute of Applied Physics, University of Tsukuba, 1-1-1 Tennodai, Tsukuba 305-8573, Japan; E-Mails: (A.T.); (Y.H.); (O.T.).

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http://dx.doi.org/10.3390/ijms13010453DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3269697PMC
February 2015

Acquired resistance to gemcitabine and cross-resistance in human pancreatic cancer clones.

Anticancer Drugs 2015 Jan;26(1):90-100

aBiomedical Laboratory, Biomedical Research Center bDepartment of Pharmacy cDepartment of Surgery, Kitasato University Kitasato Institute Hospital dDepartment of Clinical Pharmacy, School of Pharmacy, Center for Clinical Pharmacy and Clinical Sciences, Kitasato University, Tokyo, Japan.

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http://dx.doi.org/10.1097/CAD.0000000000000165DOI Listing
January 2015

Negative regulation of melanoma differentiation-associated gene 5 (MDA5)-dependent antiviral innate immune responses by Arf-like protein 5B.

J Biol Chem 2015 Jan 1;290(2):1269-80. Epub 2014 Dec 1.

From the Laboratory of Molecular Immunobiology, Graduate School of Biological Sciences, Nara Institute of Science and Technology (NAIST), 8916-5 Takayama-cho, Ikoma, Nara 630-0192, Japan,

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http://www.jbc.org/content/290/2/1269.full.pdf
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http://www.jbc.org/lookup/doi/10.1074/jbc.M114.611053
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http://dx.doi.org/10.1074/jbc.M114.611053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4294491PMC
January 2015

Akirin2 is critical for inducing inflammatory genes by bridging IκB-ζ and the SWI/SNF complex.

EMBO J 2014 Oct 8;33(20):2332-48. Epub 2014 Aug 8.

Laboratory of Infection and Prevention Institute for Virus Research Kyoto University, Sakyo-ku Kyoto, Japan CREST JST, Sakyo-ku Kyoto, Japan Laboratory of Host Defense WPI Immunology Frontier Research Center (IFReC), Osaka University Suita, Osaka, Japan

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http://dx.doi.org/10.15252/embj.201488447DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4253523PMC
October 2014

[Innate immunity].

Authors:
Osamu Takeuchi

Rinsho Ketsueki 2014 Oct;55(10):2175-82

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October 2014

Probing ultrafast spin dynamics with optical pump-probe scanning tunnelling microscopy.

Nat Nanotechnol 2014 Aug 29;9(8):588-93. Epub 2014 Jun 29.

Faculty of Pure and Applied Sciences, University of Tsukuba, Tsukuba 305-8571, Japan.

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http://dx.doi.org/10.1038/nnano.2014.125DOI Listing
August 2014

Enamel matrix derivative protein enhances production of matrixmetalloproteinase-2 by osteoblasts.

BMC Oral Health 2014 Jul 10;14:85. Epub 2014 Jul 10.

Department of Biochemistry, Osaka Dental University, Osaka, Japan.

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http://dx.doi.org/10.1186/1472-6831-14-85DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4115475PMC
July 2014

Post-transcriptional regulation of cytokine mRNA controls the initiation and resolution of inflammation.

Biotechnol Genet Eng Rev 2013 ;29:49-60

a Laboratory of Infection and Prevention, Department of Biological Responses , Institute for Virus Research, Kyoto University , Kyoto , Japan.

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http://dx.doi.org/10.1080/02648725.2013.801236DOI Listing
May 2014

Pivotal role of RNA-binding E3 ubiquitin ligase MEX3C in RIG-I-mediated antiviral innate immunity.

Proc Natl Acad Sci U S A 2014 Apr 27;111(15):5646-51. Epub 2014 Mar 27.

Laboratory of Host Defense, World Premier International Immunology Frontier Research Center, and Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Osaka 565-0871, Japan.

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http://dx.doi.org/10.1073/pnas.1401674111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3992669PMC
April 2014

Nucleic acid sensing by T cells initiates Th2 cell differentiation.

Nat Commun 2014 Apr 10;5:3566. Epub 2014 Apr 10.

1] Laboratory for Cell Signaling, RCAI, RIKEN Center for Integrative Medical Sciences (IMS-RCAI), Yokohama, Kanagawa 230-0045, Japan [2] Laboratory for Cell Signaling, WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka 565-0871, Japan.

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http://dx.doi.org/10.1038/ncomms4566DOI Listing
April 2014

Strawberry notch homologue 2 regulates osteoclast fusion by enhancing the expression of DC-STAMP.

J Exp Med 2013 Sep 26;210(10):1947-60. Epub 2013 Aug 26.

Laboratory of Host Defense, WPI Immunology Frontier Research Center (IFReC), Research Institute for Microbial Diseases, Osaka University, Suita, Osaka 565-0871, Japan.

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http://dx.doi.org/10.1084/jem.20130512DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3782043PMC
September 2013

Zinc-finger antiviral protein mediates retinoic acid inducible gene I-like receptor-independent antiviral response to murine leukemia virus.

Proc Natl Acad Sci U S A 2013 Jul 8;110(30):12379-84. Epub 2013 Jul 8.

Laboratory of Host Defense, World Premier International Immunology Frontier Research Center, Osaka University, Osaka 565-0871, Japan.

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http://dx.doi.org/10.1073/pnas.1310604110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3725099PMC
July 2013

Critical role of AZI2 in GM-CSF-induced dendritic cell differentiation.

J Immunol 2013 Jun 22;190(11):5702-11. Epub 2013 Apr 22.

Laboratory of Host Defense, Immunology Frontier Research Center, Osaka University, Suita, Osaka 565-0871, Japan.

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http://dx.doi.org/10.4049/jimmunol.1203155DOI Listing
June 2013

Arid5a controls IL-6 mRNA stability, which contributes to elevation of IL-6 level in vivo.

Proc Natl Acad Sci U S A 2013 Jun 15;110(23):9409-14. Epub 2013 May 15.

Laboratory of Immune Regulation, World Premier International Immunology Frontier Research Center, Osaka University, Osaka 565-0871, Japan.

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http://dx.doi.org/10.1073/pnas.1307419110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3677444PMC
June 2013

Combined effect of dehydroxymethylepoxyquinomicin and gemcitabine in a mouse model of liver metastasis of pancreatic cancer.

Clin Exp Metastasis 2013 Apr 31;30(4):381-92. Epub 2012 Oct 31.

Department of Surgery, Kitasato Institute Hospital, 5-9-1 Shirogane, Minato-ku, Tokyo 108-8642, Japan.

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http://dx.doi.org/10.1007/s10585-012-9544-7DOI Listing
April 2013

IL-33 causes selective mast cell tolerance to bacterial cell wall products by inducing IRAK1 degradation.

Eur J Immunol 2013 Apr 6;43(4):979-88. Epub 2013 Mar 6.

Faculty of Human and Medical Sciences, University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1002/eji.201242786DOI Listing
April 2013

Essential roles of K63-linked polyubiquitin-binding proteins TAB2 and TAB3 in B cell activation via MAPKs.

J Immunol 2013 Apr 15;190(8):4037-45. Epub 2013 Mar 15.

Laboratory of Infection and Prevention, Institute for Virus Research, Kyoto University, Kyoto 606-8507, Japan.

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http://dx.doi.org/10.4049/jimmunol.1300173DOI Listing
April 2013

Critical role of Trib1 in differentiation of tissue-resident M2-like macrophages.

Nature 2013 Mar 20;495(7442):524-8. Epub 2013 Mar 20.

Laboratory of Host Defense, WPI Immunology Frontier Research Center, Osaka University, 3-1 Yamada-oka, Suita, Osaka 565-0871, Japan.

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http://www.nature.com/articles/nature11930
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March 2013

TRAF family member-associated NF-κB activator (TANK) is a negative regulator of osteoclastogenesis and bone formation.

J Biol Chem 2012 Aug 6;287(34):29114-24. Epub 2012 Jul 6.

Laboratory of Host Defense, WPI Immunology Frontier Research Center (IFReC), Osaka University, 3-1 Yamada-oka, Suita, Osaka 565-0871, Japan.

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http://dx.doi.org/10.1074/jbc.M112.347799DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3436591PMC
August 2012

Effect of a combination of S-1 and gemcitabine on cell cycle regulation in pancreatic cancer cell lines.

Anticancer Drugs 2012 Jun;23(5):505-14

Division of Research, BioMedical Laboratory, Kitasato Institute Hospital, Tokyo, Japan.

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http://dx.doi.org/10.1097/CAD.0b013e328350e8c7DOI Listing
June 2012

IRF3: a molecular switch in pathogen responses.

Authors:
Osamu Takeuchi

Nat Immunol 2012 Jun 19;13(7):634-5. Epub 2012 Jun 19.

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http://dx.doi.org/10.1038/ni.2346DOI Listing
June 2012

Bruton's tyrosine kinase phosphorylates Toll-like receptor 3 to initiate antiviral response.

Proc Natl Acad Sci U S A 2012 Apr 27;109(15):5791-6. Epub 2012 Mar 27.

Immunology Group, Bioprocessing Technology Institute, Agency for Science, Technology and Research (ASTAR), Republic of Singapore 138668.

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http://dx.doi.org/10.1073/pnas.1119238109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3326448PMC
April 2012

Nanoscale probing of transient carrier dynamics modulated in a GaAs-PIN junction by laser-combined scanning tunneling microscopy.

Nanoscale 2012 Feb 10;4(3):757-61. Epub 2012 Jan 10.

Institute of Applied Physics, University of Tsukuba, Tsukuba, 305-8573, Japan.

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http://xlink.rsc.org/?DOI=c2nr11551d
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February 2012

Functional characterization of protein domains common to animal viruses and mouse.

BMC Genomics 2011 Nov 30;12 Suppl 3:S21. Epub 2011 Nov 30.

Institute for Protein Research, Osaka University, 3-2 Yamadaoka, Suita, Osaka 565-0871, Japan.

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http://dx.doi.org/10.1186/1471-2164-12-S3-S21DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3333181PMC
November 2011

Scanning tunneling microscopy/spectroscopy on self-assembly of a glycine/Cu(111) nanocavity array.

Chem Commun (Camb) 2011 Oct 16;47(40):11312-4. Epub 2011 Sep 16.

Institute of Applied Physics, University of Tsukuba, 305-8573 Tsukuba, Japan.

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http://dx.doi.org/10.1039/c1cc11829cDOI Listing
October 2011

The TRAF-associated protein TANK facilitates cross-talk within the IkappaB kinase family during Toll-like receptor signaling.

Proc Natl Acad Sci U S A 2011 Oct 23;108(41):17093-8. Epub 2011 Sep 23.

Medical Research Council Protein Phosphorylation Unit, College of Life Sciences, Sir James Black Centre, University of Dundee, Dundee, DD1 5EH Scotland, United Kingdom.

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http://www.pnas.org/cgi/doi/10.1073/pnas.1114194108
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3193242PMC
October 2011

The IκB kinase complex regulates the stability of cytokine-encoding mRNA induced by TLR-IL-1R by controlling degradation of regnase-1.

Nat Immunol 2011 Oct 30;12(12):1167-75. Epub 2011 Oct 30.

Laboratory of Host Defense, World Premier International Immunology Frontier Research Center, Osaka University, Osaka, Japan.

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http://www.nature.com/articles/ni.2137
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October 2011

Antiviral protein Viperin promotes Toll-like receptor 7- and Toll-like receptor 9-mediated type I interferon production in plasmacytoid dendritic cells.

Immunity 2011 Mar;34(3):352-63

Laboratory of Host Defense, WPI Immunology Frontier Research Center, Osaka University, 3-1 Yamada-oka, Suita, Osaka 565-0871, Japan.

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https://linkinghub.elsevier.com/retrieve/pii/S10747613110008
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March 2011

IL-1α modulates neutrophil recruitment in chronic inflammation induced by hydrocarbon oil.

J Immunol 2011 Feb 29;186(3):1747-54. Epub 2010 Dec 29.

Division of Rheumatology and Clinical Immunology, University of Florida, Gainesville, FL 32610, USA.

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http://dx.doi.org/10.4049/jimmunol.1001328DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3607541PMC
February 2011

Akt contributes to activation of the TRIF-dependent signaling pathways of TLRs by interacting with TANK-binding kinase 1.

J Immunol 2011 Jan 24;186(1):499-507. Epub 2010 Nov 24.

School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju, Korea.

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http://dx.doi.org/10.4049/jimmunol.0903534DOI Listing
January 2011

BID, BIM, and PUMA are essential for activation of the BAX- and BAK-dependent cell death program.

Science 2010 Dec;330(6009):1390-3

Molecular Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1126/science.1190217DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3163443PMC
December 2010

[Regulation of immune responses by mRNA stability control].

Authors:
Osamu Takeuchi

Seikagaku 2010 Dec;82(12):1124-8

Laboratory of Host Defense, WPI Immunology Frontier Research Center (IFReC), Osaka University, 3-1 Yamada-oka, Suita, Osaka 565-0871, Japan.

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December 2010

Laser-combined scanning tunnelling microscopy for probing ultrafast transient dynamics.

J Phys Condens Matter 2010 Jul 14;22(26):264008. Epub 2010 Jun 14.

Institute of Applied Physics, CREST-JST, University of Tsukuba, Tsukuba 305-8573, Japan.

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July 2010