Publications by authors named "Osamu Ohara"

100Publications

Dysregulated metabolism of polyunsaturated fatty acids in eosinophilic allergic diseases.

Prostaglandins Other Lipid Mediat 2020 Jul 23;150:106477. Epub 2020 Jul 23.

Laboratory for Metabolomics, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan; Cellular and Molecular Epigenetics Laboratory, Graduate School of Medical Life Science, Yokohama City University, Kanagawa, Japan; Division of Physiological Chemistry and Metabolism, Graduate School of Pharmaceutical Sciences, Keio University, Tokyo, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.prostaglandins.2020.106477DOI Listing
July 2020

PD-L1 Expression Affects Neoantigen Presentation.

iScience 2020 Jun 4;23(6):101238. Epub 2020 Jun 4.

Laboratory for Immunotherapy, RIKEN Center for Integrative Medical Sciences (IMS), Yokohama, Kanagawa 230-0045, Japan; RIKEN Program for Drug Discovery and Medical Technology Platform (DMP), Yokohama, Kanagawa 230-0045, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.isci.2020.101238DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322261PMC
June 2020

Clinical phenotypes and genetic analyses for diagnosis of systemic autoinflammatory diseases in adult patients with unexplained fever.

Mod Rheumatol 2020 Jul 24:1-6. Epub 2020 Jul 24.

Division of Respirology, Neurology, and Rheumatology, Department of Medicine, Kurume University School of Medicine, Kurume, Japan.

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http://dx.doi.org/10.1080/14397595.2020.1784542DOI Listing
July 2020

Microfluidic Immunoassays for Time-Resolved Measurement of Protein Secretion from Single Cells.

Annu Rev Anal Chem (Palo Alto Calif) 2020 06 7;13(1):67-84. Epub 2020 Feb 7.

Department of Biological Sciences, The University of Tokyo, Tokyo 113-0033, Japan; email:

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http://dx.doi.org/10.1146/annurev-anchem-091619-101212DOI Listing
June 2020

Human gain-of-function STAT1 mutation disturbs IL-17 immunity in mice.

Int Immunol 2020 04;32(4):259-272

Department of Pediatrics, Graduate School of Biomedical & Health Sciences, Hiroshima University, Hiroshima, Japan.

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http://dx.doi.org/10.1093/intimm/dxz079DOI Listing
April 2020

Optimization of Data-Independent Acquisition Mass Spectrometry for Deep and Highly Sensitive Proteomic Analysis.

Int J Mol Sci 2019 Nov 26;20(23). Epub 2019 Nov 26.

Department of Applied Genomics, Kazusa DNA Research Institute, Chiba 292-0818, Japan.

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http://dx.doi.org/10.3390/ijms20235932DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6928715PMC
November 2019

HaloTag-based conjugation of proteins to barcoding-oligonucleotides.

Nucleic Acids Res 2020 01;48(2):e8

Laboratory for Integrative Genomics, RIKEN Center for Integrative Medical Sciences (IMS), Yokohama City 230-0045, Japan.

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http://dx.doi.org/10.1093/nar/gkz1086DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6954424PMC
January 2020

Prognostic factors for survival of herpes simplex virus-associated hemophagocytic lymphohistiocytosis.

Int J Hematol 2020 Jan 23;111(1):131-136. Epub 2019 Sep 23.

Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.

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http://dx.doi.org/10.1007/s12185-019-02738-3DOI Listing
January 2020

PCR-free whole exome sequencing: Cost-effective and efficient in detecting rare mutations.

PLoS One 2019 13;14(9):e0222562. Epub 2019 Sep 13.

Laboratory of Clinical Omics Research, Department of Applied Genomics, Kazusa DNA Research Institute, Chiba, Japan.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0222562PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6743761PMC
March 2020

BTNL2 germline variants may be involved in the pathogenesis of renal granuloma.

Pediatr Int 2019 Aug 27;61(8):834-836. Epub 2019 Aug 27.

Division of Pediatrics, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan.

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http://dx.doi.org/10.1111/ped.13923DOI Listing
August 2019

Short DNA Probes Developed for Sample Tracking and Quality Assurance in Gene Panel Testing.

J Mol Diagn 2019 11 22;21(6):1079-1094. Epub 2019 Aug 22.

Department of Technology Development, Kazusa DNA Research Institute, Kisarazu, Japan.

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http://dx.doi.org/10.1016/j.jmoldx.2019.07.003DOI Listing
November 2019

Autosomal dominant Hashimoto's thyroiditis with a mutation in .

Clin Pediatr Endocrinol 2019 20;28(3):91-96. Epub 2019 Jul 20.

Department of Pediatrics, Graduate School of Medicine, Gifu University, Gifu, Japan.

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http://dx.doi.org/10.1297/cpe.28.91DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6646238PMC
July 2019

TGF-β signaling promotes tube-structure-forming growth in pancreatic duct adenocarcinoma.

Sci Rep 2019 08 2;9(1):11247. Epub 2019 Aug 2.

Department of Molecular and Tumor Pathology, Graduate School of Medicine, Chiba University, Chiba, 260-8670, Japan.

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http://dx.doi.org/10.1038/s41598-019-47101-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6677751PMC
August 2019

Cysteinyl leukotriene metabolism of human eosinophils in allergic disease.

Allergol Int 2020 Jan 24;69(1):28-34. Epub 2019 Jun 24.

Laboratory for Metabolomics, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan; Cellular and Molecular Epigenetics Laboratory, Graduate School of Medical Life Science, Yokohama City University, Kanagawa, Japan; Division of Physiological Chemistry and Metabolism, Keio University Faculty of Pharmacy, Tokyo, Japan.

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http://dx.doi.org/10.1016/j.alit.2019.06.002DOI Listing
January 2020

Low-frequency mosaicism in cryopyrin-associated periodic fever syndrome: mosaicism in systemic autoinflammatory diseases.

Int Immunol 2019 09;31(10):649-655

Department of Pediatrics, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

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http://dx.doi.org/10.1093/intimm/dxz047DOI Listing
September 2019

Eomes transcription factor is required for the development and differentiation of invariant NKT cells.

Commun Biol 2019 29;2:150. Epub 2019 Apr 29.

Laboratory for Immunotherapy, RIKEN Center for Integrative Medical Sciences (IMS), Yokohama, Kanagawa 230-0045 Japan.

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http://www.nature.com/articles/s42003-019-0389-3
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http://dx.doi.org/10.1038/s42003-019-0389-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6488575PMC
April 2020

Inhibition of T cell activation and function by the adaptor protein CIN85.

Sci Signal 2019 02 5;12(567). Epub 2019 Feb 5.

Laboratory for Cell Signaling, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa 230-0045, Japan.

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http://dx.doi.org/10.1126/scisignal.aav4373DOI Listing
February 2019

Dysregulated fatty acid metabolism in nasal polyp-derived eosinophils from patients with chronic rhinosinusitis.

Allergy 2019 06 26;74(6):1113-1124. Epub 2019 Feb 26.

Laboratory for Metabolomics, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan.

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http://dx.doi.org/10.1111/all.13726DOI Listing
June 2019

Mosaicism of an ELANE Mutation in an Asymptomatic Mother.

J Clin Immunol 2019 01 12;39(1):106-111. Epub 2019 Jan 12.

Department of Pediatrics, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, 390-8621, Japan.

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http://dx.doi.org/10.1007/s10875-018-0580-1DOI Listing
January 2019

Improving the efficiency of gene insertion in a human artificial chromosome vector and its transfer in human-induced pluripotent stem cells.

Biol Methods Protoc 2018 31;3(1):bpy013. Epub 2018 Dec 31.

Laboratory of Clinical Omics Research, Department of Applied Genomics, Kazusa DNA Research Institute, Chiba, Japan.

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http://dx.doi.org/10.1093/biomethods/bpy013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6994043PMC
December 2018

Obesity Drives STAT-1-Dependent NASH and STAT-3-Dependent HCC.

Cell 2018 11 25;175(5):1289-1306.e20. Epub 2018 Oct 25.

Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia; Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00928674183130
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http://dx.doi.org/10.1016/j.cell.2018.09.053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6242467PMC
November 2018

Proteogenomic Analyses of Cellular Lysates Using a Phenol-Guanidinium Thiocyanate Reagent.

J Proteome Res 2019 01 12;18(1):301-308. Epub 2018 Nov 12.

Department of Genome Research and Development , Kazusa DNA Research Institute , Kisarazu , Chiba 292-0818 , Japan.

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http://pubs.acs.org/doi/10.1021/acs.jproteome.8b00609
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http://dx.doi.org/10.1021/acs.jproteome.8b00609DOI Listing
January 2019

Development of a NanoLC-MS/MS System Using a Nonporous Reverse Phase Column for Ultrasensitive Proteome Analysis.

Anal Chem 2018 11 16;90(21):12334-12338. Epub 2018 Oct 16.

Laboratory for Integrative Genomics , RIKEN Center for Integrative Medical Sciences , Yokohama , Kanagawa 230-0045 , Japan.

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http://dx.doi.org/10.1021/acs.analchem.8b03382DOI Listing
November 2018

Sox12 promotes T reg differentiation in the periphery during colitis.

J Exp Med 2018 10 6;215(10):2509-2519. Epub 2018 Sep 6.

Department of Allergy and Clinical Immunology, Graduate School of Medicine, Chiba University, Japan

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http://dx.doi.org/10.1084/jem.20172082DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6170178PMC
October 2018

Variant PRC1 competes with retinoic acid-related signals to repress in the mouse distal forelimb bud.

Development 2018 10 11;145(19). Epub 2018 Oct 11.

Laboratory for Developmental Genetics, RIKEN Center for Integrative Medical Sciences (RIKEN-IMS), 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan

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http://dx.doi.org/10.1242/dev.166348DOI Listing
October 2018

Recurrent Acute Abdomen as the Main Manifestation of Hereditary Angioedema.

Intern Med 2019 Jan 24;58(2):213-216. Epub 2018 Aug 24.

Department of Pediatrics and Developmental Biology, Tokyo Medical and Dental University, Japan.

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http://dx.doi.org/10.2169/internalmedicine.1559-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378167PMC
January 2019

Clinical and molecular features of X-linked hyper IgM syndrome - An experience from North India.

Clin Immunol 2018 10 25;195:59-66. Epub 2018 Jul 25.

Pediatric Allergy and Immunology Unit, Advanced Pediatrics Centre, Postgraduate Institute of Medical Education and Research, Chandigarh, India. Electronic address:

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http://dx.doi.org/10.1016/j.clim.2018.07.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6666391PMC
October 2018

Challenges in Developing Protein Secretion Assays at a Single-Cell Level.

Methods Mol Biol 2018 ;1808:1-7

Laboratory for Integrative Genomics, RIKEN Center for Integrative Medical Sciences, Tokyo, Japan.

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http://dx.doi.org/10.1007/978-1-4939-8567-8_1DOI Listing
March 2019

Development of a molecular diagnostic test for Retinitis Pigmentosa in the Japanese population.

Jpn J Ophthalmol 2018 Jul 21;62(4):451-457. Epub 2018 May 21.

Laboratory for Retinal Regeneration, RIKEN Center for Developmental Biology, 2-2-3 Minatojimaminamimachi, Chuo-ku, Kobe, Hyogo, 650-0047, Japan.

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http://dx.doi.org/10.1007/s10384-018-0601-xDOI Listing
July 2018

Comprehensive molecular diagnosis of Epstein-Barr virus-associated lymphoproliferative diseases using next-generation sequencing.

Int J Hematol 2018 Sep 18;108(3):319-328. Epub 2018 May 18.

Department of Pediatrics and Developmental Biology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8519, Japan.

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http://dx.doi.org/10.1007/s12185-018-2475-6DOI Listing
September 2018

Inborn Errors of RNA Lariat Metabolism in Humans with Brainstem Viral Infection.

Cell 2018 02;172(5):952-965.e18

St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065, USA; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Paris 75015, France; Paris Descartes University, Imagine Institute, Paris 75015, France; Howard Hughes Medical Institute, New York, NY 10065, USA; Pediatric Immunology-Hematology Unit, Necker Hospital for Sick Children, Paris 75015, France.

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http://dx.doi.org/10.1016/j.cell.2018.02.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5886375PMC
February 2018

Identification of Protein Targets of 12/15-Lipoxygenase-Derived Lipid Electrophiles in Mouse Peritoneal Macrophages Using Omega-Alkynyl Fatty Acid.

ACS Chem Biol 2018 04 1;13(4):887-893. Epub 2018 Mar 1.

Graduate School of Medical Life Science , Yokohama City University , 1-7-29, Suehiro-cho, Tsurumi , Yokohama , Kanagawa 230-0045 , Japan.

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http://dx.doi.org/10.1021/acschembio.7b01092DOI Listing
April 2018

Rbm10 regulates inflammation development via alternative splicing of Dnmt3b.

Int Immunol 2017 12;29(12):581-591

Division of Molecular Psychoimmunology, Institute for Genetic Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.

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http://academic.oup.com/intimm/article/29/12/581/4773579
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http://dx.doi.org/10.1093/intimm/dxx067DOI Listing
December 2017

NK cell and IFN signatures are positive prognostic biomarkers for resectable pancreatic cancer.

Biochem Biophys Res Commun 2018 01 15;495(2):2058-2065. Epub 2017 Dec 15.

Hepato-Biliary-Pancreatic Surgery Division, Department of Surgery, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo 113-8655, Japan; National Center for Global Health and Medicine, Shinjuku-ku, Tokyo 162-8655, Japan.

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http://dx.doi.org/10.1016/j.bbrc.2017.12.083DOI Listing
January 2018

Haploinsufficiency of A20 causes autoinflammatory and autoimmune disorders.

J Allergy Clin Immunol 2018 04 11;141(4):1485-1488.e11. Epub 2017 Dec 11.

Department of Pediatrics and Developmental Biology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2017.10.039DOI Listing
April 2018

Accurate clinical genetic testing for autoinflammatory diseases using the next-generation sequencing platform MiSeq.

Biochem Biophys Rep 2017 Mar 23;9:146-152. Epub 2016 Dec 23.

Department of Technology Development, Kazusa DNA Research Institute, 2-6-7 Kazusa-Kamatari, Kisarazu, Chiba 292-0818, Japan.

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http://dx.doi.org/10.1016/j.bbrep.2016.12.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5614572PMC
March 2017

Immunodeficiency in Two Female Patients with Incontinentia Pigmenti with Heterozygous NEMO Mutation Diagnosed by LPS Unresponsiveness.

J Clin Immunol 2017 Aug 12;37(6):529-538. Epub 2017 Jul 12.

Department of Pediatrics, Graduate School of Medicine, Gifu University, 1-1 Yanagido, Gifu, 501-1194, Japan.

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http://link.springer.com/10.1007/s10875-017-0417-3
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http://dx.doi.org/10.1007/s10875-017-0417-3DOI Listing
August 2017

Heterozygous carriers of succinyl-CoA:3-oxoacid CoA transferase deficiency can develop severe ketoacidosis.

J Inherit Metab Dis 2017 11 10;40(6):845-852. Epub 2017 Jul 10.

Department of Pediatrics, Graduate School of Medicine, Gifu University, 1-1 Yanagido, Gifu City, Gifu, 501-1194, Japan.

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http://dx.doi.org/10.1007/s10545-017-0065-zDOI Listing
November 2017

Mitochonic Acid 5 (MA-5) Facilitates ATP Synthase Oligomerization and Cell Survival in Various Mitochondrial Diseases.

EBioMedicine 2017 Jun 13;20:27-38. Epub 2017 May 13.

Division of Nephrology, Endocrinology and Vascular Medicine, Tohoku University Graduate School of Medicine, Sendai 980-8574, Japan; Department of Medical Science, Tohoku University Graduate School of Biomedical Engineering, Sendai 980-8574, Japan; Department of Clinical Biology and Hormonal Regulation, Tohoku University Graduate School of Medicine, Sendai 980-8574, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.ebiom.2017.05.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5478234PMC
June 2017

Nationwide survey of Baller‑Gerold syndrome in Japanese population.

Mol Med Rep 2017 May 28;15(5):3222-3224. Epub 2017 Mar 28.

Department of Clinical Research, National Hospital Organization Nagara Medical Center, Gifu 502‑8558, Japan.

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http://dx.doi.org/10.3892/mmr.2017.6408DOI Listing
May 2017

A deletion in the intergenic region upstream of Ednrb causes head spot in the rat strain KFRS4/Kyo.

BMC Genet 2017 03 29;18(1):29. Epub 2017 Mar 29.

Medical Institute of Bioregulation, Kyushu University, Fukuoka, 812-8582, Japan.

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http://dx.doi.org/10.1186/s12863-017-0497-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5372274PMC
March 2017

Infection Profile in Chronic Granulomatous Disease: a 23-Year Experience from a Tertiary Care Center in North India.

J Clin Immunol 2017 Apr 22;37(3):319-328. Epub 2017 Mar 22.

Pediatric Allergy and Immunology Unit, Advanced Pediatrics Centre, Department of Pediatrics, Postgraduate Institute of Medical Education and Research, Chandigargh, 160012, India.

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http://dx.doi.org/10.1007/s10875-017-0382-xDOI Listing
April 2017

Molecular mechanism and structural basis of gain-of-function of STAT1 caused by pathogenic R274Q mutation.

J Biol Chem 2017 04 3;292(15):6240-6254. Epub 2017 Mar 3.

From the Department of Technology Development, Kazusa DNA Research Institute, 2-6-7 Kazusa-Kamatari, Kisarazu-Shi, Chiba-Ken, 292-0818.

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http://dx.doi.org/10.1074/jbc.M116.753848DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5391754PMC
April 2017

Alternative pathway for the development of V14 NKT cells directly from CD4CD8 thymocytes that bypasses the CD4CD8 stage.

Nat Immunol 2017 03 30;18(3):274-282. Epub 2017 Jan 30.

Laboratory for Immune Regulation, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.

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http://dx.doi.org/10.1038/ni.3668DOI Listing
March 2017

IκBNS enhances follicular helper T-cell differentiation and function downstream of ASCl2.

J Allergy Clin Immunol 2017 07 28;140(1):288-291.e8. Epub 2016 Dec 28.

Department of Allergy and Clinical Immunology, Graduate School of Medicine, Chiba University, Chiba, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2016.10.047DOI Listing
July 2017

Application of target capture sequencing of exons and conserved non-coding sequences to 20 inbred rat strains.

Genom Data 2016 Dec 14;10:155-157. Epub 2016 Nov 14.

Medical Institute of Bioregulation, Kyushu University, Maidashi 3-1-1, Higashi-ku, Fukuoka 812-8582, Japan; AMED-CREST, Japan Agency for Medical Research and Development, Fukuoka 812-8582, Japan.

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http://dx.doi.org/10.1016/j.gdata.2016.11.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5114524PMC
December 2016

Protective neutralizing influenza antibody response in the absence of T follicular helper cells.

Nat Immunol 2016 Dec 31;17(12):1447-1458. Epub 2016 Oct 31.

Laboratory for Cytokine Regulation, Research Center for Integrative Medical Science (IMS), RIKEN Yokohama Institute, Yokohama, Japan.

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http://dx.doi.org/10.1038/ni.3563DOI Listing
December 2016