Publications by authors named "Osama B Abdel-Halim"

7 Publications

  • Page 1 of 1

New prenylated flavonoid and neuroprotective compounds from subsp. .

Nat Prod Res 2020 Sep 2:1-9. Epub 2020 Sep 2.

Department of Pharmacognosy, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt.

Continuation of the phytochemical investigation of the aerial parts of subsp. resulted in the isolation and structural elucidation of a new prenylated flavonoid demeapollinin (), glabratephrinol () and a mixture () of tephroapollin G () and -tephroapollin G (). The neuroprotective activity of compounds () besides the previously isolated compounds; dunensin (), pseudosemiglabrin (), glabratephrin (), apollinin (), kampferol 3, 7--α-L-dirhamnoside () and quercetin 3, 7--α-L-dirhamnoside () was examined. Molecular docking, acetylcholine esterase inhibitory assay and protection against both HO and induced neurotoxicity were used to evaluate their neuroprotective effect. Compound showed the highest acetylcholine esterase inhibitory activity (IC 4.31 ± 0.75 µM) compared to galantamine (IC 1.64 ± 0.32 µM), compounds and exhibited potent protective effect against induced neurotoxicity (IC 7.70 ± 5.23 and 10.91 ± 6.27 µM, respectively) compared to standard epigallocatechin gallate (IC 18.36 ± 6.22 µM).
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http://dx.doi.org/10.1080/14786419.2020.1815739DOI Listing
September 2020

Protective effects of Ajwa date extract against tissue damage induced by acute diclofenac toxicity.

J Taibah Univ Med Sci 2019 Dec 27;14(6):553-559. Epub 2019 Nov 27.

Department of Pharmacognosy and Pharmaceutical Chemistry, College of Pharmacy, Taibah University, Almadinah Almunawwarah, KSA.

Objectives: To investigate the tissue-protective effects of Ajwa date fruits (a Prophetic medicinal remedy) against acute diclofenac toxicity.

Methods: Albino Sprague-Dawley rats were allocated to four experimental groups: a negative control group, an Ajwa-only group that received 2 g/kg of Ajwa date extract (ADE) orally, an acute diclofenac toxicity group that received 200 mg diclofenac once intraperitoneally, and a treatment group that received diclofenac and ADE after 4 h. Histological examinations of rat lung and liver tissues were performed.

Results: Acute diclofenac toxicity caused marked hepatic derangements, such as congested central veins, congested blood sinusoids, hyaline degeneration, and hepatocyte necrosis. Toxic diclofenac overdose resulted in markedly congested alveolar capillaries and alveolar haemorrhages, thick edematous alveolar walls, and edema fluid exudates in the alveoli. Upon treatment with ADE, significant reduction in diclofenac-induced hepatic and pulmonary derangements were observed.

Conclusion: ADE is a safe, tissue-protective nutritional agent that alleviates cellular and tissue-damaging effects due to acute diclofenac toxicity. ADE relieved hepatic and pulmonary changes induced by acute diclofenac toxicity. The use of ADE is recommended for the treatment of acute diclofenac toxicity.
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http://dx.doi.org/10.1016/j.jtumed.2019.10.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6940670PMC
December 2019

New ent-kaurane diterpenoid dimer from Pulicaria inuloides.

Nat Prod Res 2016 Nov 27;30(21):2468-75. Epub 2016 Jun 27.

a Faculty of Pharmacy, Department of Pharmacognosy , Mansoura University , Mansoura , Egypt.

A new naturally occurring ent-kaurane diterpenoid dimer, 15β, 15'β-oxybis (ent-kaur-16-en-19-oic acid) (1) along with six known compounds, 15β-hydroxy-ent-kaur-16-en-19-oic acid (2), 15β-hydroxy-ent-kaur-16-en-19-oate-β-d-glucopyranoside (3), 6-hydroxykaempferol-3, 7-dimethyl ether (4), quercetagetin 3, 7, 3'-trimethyl ether (5), β-sitosterol (6) and β-sitosterol glucoside (daucosterol) (7) were isolated from the aerial parts of Pulicaria inuloides DC. Compounds 2-5 were isolated for the first time from genus Pulicaria. The structures of compounds 1-7 were established on the basis of extensive 1D and 2D NMR spectroscopic techniques in combination with ESI-MS. The antimicrobial activity of the isolated compounds was evaluated against Staphylococcus aureus, Escherichia coli and Candida albicans. Sulphorhodamine B cytotoxic assay against HepG2 (liver cancer) cell line and ABTS antioxidant assay were carried out.
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http://dx.doi.org/10.1080/14786419.2016.1201671DOI Listing
November 2016

Dendrocyin: an isocucurbitacin with novel cyclic side chain from Dendrosicyos socotrana.

Phytochemistry 2004 Sep;65(18):2551-6

Pharmacognosy Department, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt.

Dendrosicyos socotrana Balf.f. is a unique species (Cucurbitaceae) native to Socotra island in the horn of Africa. From the chloroform extract of the stems, A new isocucurbitacin (Dendrocyin) with unusual cyclization in the side chain; 24beta-ethoxy-20-25-epoxy-3alpha,16alpha-dihydroxy-9-methyl-19-norlanost-5(6) ene-2,11,22-trione has been isolated alongside isocucurbitacin R. Their structural configuration were established by usual spectroscopic (1H NMR, 13C NMR and DEPT) and two-dimensional NMR techniques (1H-1H Cosy, HMBC and HMQC).
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http://dx.doi.org/10.1016/j.phytochem.2004.07.016DOI Listing
September 2004

Cytotoxic hydroazulene diterpenes from the brown alga Cystoseira myrica.

Z Naturforsch C J Biosci 2003 Jan-Feb;58(1-2):33-8

Department of Chemistry, Faculty of Science, Mansoura University, New Damietta, Egypt.

Cytotoxicity-guided fractionation of the alcohol extract of the brown alga, Cystoseira myrica, afforded four new cytotoxic hydroazulene diterpenes, dictyone acetate (2), dictyol F monoacetate (4), isodictytriol monoacetate (6), and cystoseirol monoacetate (8), together with two known cytotoxic hydroazulene diterpenes, pachydictyol A (1) and dictyone (3). The constitution of each isolated compound has been determined on the basis of spectroscopic and chemical evidence.
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http://dx.doi.org/10.1515/znc-2003-1-205DOI Listing
April 2003

New erythroxane-type diterpenoids from Fagonia boveana (Hadidi) Hadidi & Graf.

Z Naturforsch C J Biosci 2003 Jan-Feb;58(1-2):23-32

Department of Pharmacognosy, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt.

The aerial parts of Fagonia boveana afforded two new erythroxane-type diterpenes, 3beta,15,16-trihydroxy-erythrox-4(18)-ene (2) and 15,16-dihydroxy-cis-ent-erythrox-3-ene (fagonene) (3) together with two known ones; 16-O-acetylfagonone (1) and 7beta-hydroxy fagonene (8). Also a new guaiane sesquiterpene alcohol, 6,10-epoxy-4alpha-hydroxy guaiane type sesquiterpene (4) has been isolated. In addition three 8-methoxy flavonols, 8-methoxy-quercetin-3,7,3'-trimethyl ether (ternatin) (5), gossypetin, 3,8,3',4' tetramethyl ether (6) and herbacetin-3,8-dimethyl ether (7) were also isolated. The structures of the isolated compounds have been determined on the basis of spectroscopic evidences as well as physical and chemical correlation with known compounds. On performing different assays for biological activities, 6 displayed significant cytotoxic activity against KA3IT and NIH3T3 cell lines, 8 was the most active antiviral against Herpes simplex type 1 while 7 was the most active cancer-preventive agent using protein-tyrosine kinase inhibitory method.
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http://dx.doi.org/10.1515/znc-2003-1-204DOI Listing
April 2003

Cytotoxic hydroazulene diterpenes from the brown alga Dictyota dichotoma.

Z Naturforsch C J Biosci 2003 Jan-Feb;58(1-2):17-22

Department of Pharmacognosy, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt.

Two new hydroazulenoid (prenyl guaiane) diterpenes, dictyone acetate (2) and 3,4-epoxy 13-hydroxy pachydictyol A (4) were isolated from the petroleum ether fraction of the alcoholic extract of the brown alga, Dictyota dichotoma (Hudson) Lamouroux, which was collected from the Red Sea coasts at Hurgada, Egypt, together with three known ones, pachydictyol A (1), dictyone (3) and 11-hydroxypachydictyol A (dictyol E) (5). In addition, the steroidal compound, stigmasta-5,(E)-24(28)-dien-3-beta-ol (fucosterol) (6) was also isolated. The structures of the isolated compounds have been determined on the basis of spectroscopic evidences as well as physical and chemical correlation with known compounds. Compounds 1, 2, 3 and 5 showed moderate cytotoxic activity.
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http://dx.doi.org/10.1515/znc-2003-1-203DOI Listing
April 2003