Orla Howe

Orla Howe

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Orla Howe

Orla Howe

Publications by authors named "Orla Howe"

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28Publications

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Copper(II) complexes of coumarin-derived Schiff base ligands: Pro- or antioxidant activity in MCF-7 cells?

J Inorg Biochem 2019 Aug 5;197:110702. Epub 2019 May 5.

Centre of Applied Science and Health, TU Dublin - Tallaght Campus, Tallaght D24 FKT9, Ireland. Electronic address:

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http://dx.doi.org/10.1016/j.jinorgbio.2019.110702DOI Listing
August 2019

DNA Damage and Cytokine Production in Non-Target Irradiated Lymphocytes.

Radiat Res 2019 06 17;191(6):545-555. Epub 2019 Apr 17.

a Radiation and Environmental Science Centre, FOCAS Institute.

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http://www.rrjournal.org/doi/10.1667/RR15165.1
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http://dx.doi.org/10.1667/RR15165.1DOI Listing
June 2019

Tetrameric and polymeric silver complexes of the omeprazole scaffold; synthesis, structure, in vitro and in vivo antimicrobial activities and DNA interaction.

J Inorg Biochem 2018 09 31;186:317-328. Epub 2018 May 31.

Department of Physics, Chemistry and Pharmacy, University of Southern Denmark, Campusvej 55, 5230 Odense M, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.jinorgbio.2018.05.018DOI Listing
September 2018

Targeting the Folate Receptor: Improving Efficacy in Inorganic Medicinal Chemistry.

Curr Med Chem 2018 ;25(23):2675-2708

The Centre for Biomimetic & Therapeutic Research, Focas Research Institute, Dublin Institute of Technology, Camden Row, Dublin 8, Ireland.

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http://dx.doi.org/10.2174/0929867325666180209143715DOI Listing
July 2018

Doxorubicin kinetics and effects on lung cancer cell lines using in vitro Raman micro-spectroscopy: binding signatures, drug resistance and DNA repair.

J Biophotonics 2018 01 21;11(1). Epub 2017 Jun 21.

FOCAS Research Institute, Dublin Institute of Technology, Kevin Street, Dublin 8, Ireland.

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http://dx.doi.org/10.1002/jbio.201700060DOI Listing
January 2018

The Antibacterial Activity of Metal Complexes Containing 1,10- phenanthroline: Potential as Alternative Therapeutics in the Era of Antibiotic Resistance.

Curr Top Med Chem 2017 ;17(11):1280-1302

College of Sciences and Health, Dublin Institute of Technology, Kevin Street, Dublin 8, Ireland.

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http://dx.doi.org/10.2174/1568026616666161003143333DOI Listing
April 2017

Vibrational spectroscopy in sensing radiobiological effects: analyses of targeted and non-targeted effects in human keratinocytes.

Faraday Discuss 2016 06;187:213-34

School of Physics, Dublin Institute of Technology, Kevin Street, Dublin 8, Ireland. and DIT Centre for Radiation and Environmental Science, Focas Research Institute, Dublin Institute of Technology, Camden Row, Dublin 8, Ireland.

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http://dx.doi.org/10.1039/c5fd00208gDOI Listing
June 2016

Non-thermal atmospheric plasma induces ROS-independent cell death in U373MG glioma cells and augments the cytotoxicity of temozolomide.

Br J Cancer 2016 Feb 4;114(4):435-43. Epub 2016 Feb 4.

BioPlasma Research Group, School of Food Science and Environmental Health, Dublin Institute of Technology, Dublin, Ireland.

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http://dx.doi.org/10.1038/bjc.2016.12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4815779PMC
February 2016

[Cu(o-phthalate)(phenanthroline)] Exhibits Unique Superoxide-Mediated NCI-60 Chemotherapeutic Action through Genomic DNA Damage and Mitochondrial Dysfunction.

ACS Chem Biol 2016 Jan 10;11(1):159-71. Epub 2015 Nov 10.

School of Chemical Sciences and National Institute for Cellular Biotechnology, Dublin City University , Glasnevin, Dublin 9, Ireland.

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http://dx.doi.org/10.1021/acschembio.5b00513DOI Listing
January 2016

Identification of Key Proteins in Human Epithelial Cells Responding to Bystander Signals From Irradiated Trout Skin.

Dose Response 2015 Jul-Sep;13(3):1559325815597669. Epub 2015 Jul 24.

DIT Centre for Radiation and Environmental Science, Focas Research Institute, Dublin Institute of Technology, Dublin, Ireland ; School of Biological Sciences, College of Sciences and Health, Dublin Institute of Technology, Dublin, Ireland.

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http://dx.doi.org/10.1177/1559325815597669DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4674182PMC
December 2015

Regulating bioactivity of Cu2+ bis-1,10-phenanthroline artificial metallonucleases with sterically functionalized pendant carboxylates.

J Med Chem 2013 Nov 6;56(21):8599-615. Epub 2013 Nov 6.

School of Chemical Sciences and the National Institute for Cellular Biotechnology, Dublin City University , Dublin 9, Ireland.

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http://pubs.acs.org/doi/10.1021/jm401465m
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http://dx.doi.org/10.1021/jm401465mDOI Listing
November 2013

Apoptosis is signalled early by low doses of ionising radiation in a radiation-induced bystander effect.

Mutat Res 2013 Jan-Feb;741-742:35-43. Epub 2013 Feb 20.

Dublin Institute of Technology, Dublin 8, Ireland.

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http://dx.doi.org/10.1016/j.mrfmmm.2013.02.001DOI Listing
July 2013

Radical-induced DNA damage by cytotoxic square-planar copper(II) complexes incorporating o-phthalate and 1,10-phenanthroline or 2,2'-dipyridyl.

Free Radic Biol Med 2012 Aug 1;53(3):564-76. Epub 2012 Jun 1.

School of Chemical Sciences and National Institute for Cellular Biotechnology, Dublin City University, Glasnevin, Dublin 9, Ireland.

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http://dx.doi.org/10.1016/j.freeradbiomed.2012.05.034DOI Listing
August 2012

Quantitative reagent-free detection of fibrinogen levels in human blood plasma using Raman spectroscopy.

Analyst 2012 Apr 2;137(8):1807-14. Epub 2012 Mar 2.

RESC, Focas Research Institute, Dublin Institute of Technology, Kevin Street, Dublin 8, Ireland.

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http://xlink.rsc.org/?DOI=c2an35042d
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http://dx.doi.org/10.1039/c2an35042dDOI Listing
April 2012

DNA cleavage reactions of the dinuclear chemotherapeutic agent copper(II) bis-1,10- phenanthroline terephthalate.

Int J Clin Pharmacol Ther 2012 Jan;50(1):79-81

The inorganic pharmaceutical and biomimetic research center, Focas Research Institute, Dublin Institute of Technology, Dublin, Ireland.

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http://dx.doi.org/10.5414/cpp50079DOI Listing
January 2012

Reactive oxygen species-induced release of signalling factors in irradiated cells triggers membrane signalling and calcium influx in bystander cells.

Int J Radiat Biol 2011 Jul 7;87(7):683-95. Epub 2011 Feb 7.

Radiation and Environmental Science Centre, Focas Research Institute, Dublin Institute of Technology, Ireland.

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http://dx.doi.org/10.3109/09553002.2010.549533DOI Listing
July 2011

Bis-phenanthroline copper(II) phthalate complexes are potent in vitro antitumour agents with 'self-activating' metallo-nuclease and DNA binding properties.

Dalton Trans 2011 Feb 16;40(5):1024-7. Epub 2010 Dec 16.

The inorganic pharmaceutical and biomimetic research centre, Focas Research Institute, Dublin Institute of Technology, Camden Row, Dublin, 8, Ireland.

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http://dx.doi.org/10.1039/c0dt01607aDOI Listing
February 2011

Evaluation of the potential of Raman microspectroscopy for prediction of chemotherapeutic response to cisplatin in lung adenocarcinoma.

Analyst 2010 Dec 7;135(12):3070-6. Epub 2010 Oct 7.

DIT Centre for Radiation and Environmental Science (RESC), Focas Research Institute, Dublin Institute of Technology, Kevin Street, Dublin, 8, Ireland.

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http://dx.doi.org/10.1039/c0an00541jDOI Listing
December 2010

Do radiation-induced bystander effects correlate to the intrinsic radiosensitivity of individuals and have clinical significance?

Radiat Res 2009 May;171(5):521-9

Radiation and Environmental Science Centre, Dublin Institute of Technology, Dublin 8, Ireland.

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http://dx.doi.org/10.1667/RR1579.1DOI Listing
May 2009

Cell death mechanisms associated with G2 radiosensitivity in patients with prostate cancer and benign prostatic hyperplasia.

Radiat Res 2005 Nov;164(5):627-34

Radiation and Environmental Science Centre, Focus Institute, Dublin Institute of Technology, Dublin 8, Ireland.

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http://dx.doi.org/10.1667/rr3454.1DOI Listing
November 2005

Aprataxin, a novel protein that protects against genotoxic stress.

Hum Mol Genet 2004 May 25;13(10):1081-93. Epub 2004 Mar 25.

Radiation Biology and Oncology, The Queensland Institute of Medical Research, Herston, Australia.

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http://dx.doi.org/10.1093/hmg/ddh122DOI Listing
May 2004