Orla Hardiman

Orla Hardiman

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Orla Hardiman

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The clinical and radiological profile of primary lateral sclerosis: a population-based study.

J Neurol 2019 Nov 19;266(11):2718-2733. Epub 2019 Jul 19.

Computational Neuroimaging Group, TBSI, Trinity College Dublin, Dublin, Ireland.

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http://dx.doi.org/10.1007/s00415-019-09473-zDOI Listing
November 2019

Widespread subcortical grey matter degeneration in primary lateral sclerosis: a multimodal imaging study with genetic profiling.

Neuroimage Clin 2019 Nov 12;24:102089. Epub 2019 Nov 12.

Computational Neuroimaging Group, Biomedical Sciences Institute, Trinity College Dublin, 152-160 Pearse Street, Dublin 2, Ireland. Electronic address:

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http://dx.doi.org/10.1016/j.nicl.2019.102089DOI Listing
November 2019

Generation of six induced pluripotent stem cell (iPSC) lines from two patients with amyotrophic lateral sclerosis (NUIGi043-A, NUIGi043-B, NUIGi043-C, NUIGi044-A, NUIGi044-B, NUIGi044-C).

Stem Cell Res 2019 Oct 29;40:101558. Epub 2019 Aug 29.

Regenerative Medicine Institute (REMEDI), School of Medicine, National University of Ireland Galway, Galway, Ireland; FutureNeuro Research Centre, Royal College of Surgeons in Ireland, Dublin D02, Ireland. Electronic address:

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http://dx.doi.org/10.1016/j.scr.2019.101558DOI Listing
October 2019

Brainstem pathology in amyotrophic lateral sclerosis and primary lateral sclerosis: A longitudinal neuroimaging study.

Neuroimage Clin 2019 Oct 24;24:102054. Epub 2019 Oct 24.

Computational Neuroimaging Group, Biomedical Sciences Institute, Trinity College Dublin, 152-160 Pearse Street, Dublin 2, Ireland.

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http://dx.doi.org/10.1016/j.nicl.2019.102054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6849418PMC
October 2019

Measuring network disruption in neurodegenerative diseases: New approaches using signal analysis.

J Neurol Neurosurg Psychiatry 2019 Sep 13;90(9):1011-1020. Epub 2019 Feb 13.

Academic Unit of Neurology, Trinity College Dublin, the University of Dublin, Dublin, Ireland

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http://jnnp.bmj.com/lookup/doi/10.1136/jnnp-2018-319581
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http://dx.doi.org/10.1136/jnnp-2018-319581DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6820156PMC
September 2019

Two heads are better than one: benefits of joint models for ALS trials.

J Neurol Neurosurg Psychiatry 2019 Sep 11;90(9):1071-1072. Epub 2019 Apr 11.

Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands.

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http://jnnp.bmj.com/lookup/doi/10.1136/jnnp-2019-320553
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http://dx.doi.org/10.1136/jnnp-2019-320553DOI Listing
September 2019

Multicentre, population-based, case-control study of particulates, combustion products and amyotrophic lateral sclerosis risk.

J Neurol Neurosurg Psychiatry 2019 Aug 8;90(8):854-860. Epub 2019 Mar 8.

Department of Neurology, Brain Centre Rudolf Magnus, University Medical Centre Utrecht, Utrecht, The Netherlands

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http://dx.doi.org/10.1136/jnnp-2018-319779DOI Listing
August 2019

Lifetime Risk and Heritability of Amyotrophic Lateral Sclerosis.

JAMA Neurol 2019 Jul 22. Epub 2019 Jul 22.

Academic Unit of Neurology, Trinity College Dublin, Dublin, Ireland.

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http://dx.doi.org/10.1001/jamaneurol.2019.2044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6646974PMC
July 2019

Post-polio Syndrome: More Than Just a Lower Motor Neuron Disease.

Front Neurol 2019 16;10:773. Epub 2019 Jul 16.

Computational Neuroimaging Group, Academic Unit of Neurology, Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.

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https://www.frontiersin.org/article/10.3389/fneur.2019.00773
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http://dx.doi.org/10.3389/fneur.2019.00773DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6646725PMC
July 2019

Primary lateral sclerosis: a distinct entity or part of the ALS spectrum?

Amyotroph Lateral Scler Frontotemporal Degener 2019 05 18;20(3-4):133-145. Epub 2019 Jan 18.

a Computational Neuroimaging Group, Academic Unit of Neurology , Biomedical Sciences Institute, Trinity College , Dublin , Ireland.

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https://www.tandfonline.com/doi/full/10.1080/21678421.2018.1
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http://dx.doi.org/10.1080/21678421.2018.1550518DOI Listing
May 2019

Tracking a Fast-Moving Disease: Longitudinal Markers, Monitoring, and Clinical Trial Endpoints in ALS.

Front Neurol 2019 19;10:229. Epub 2019 Mar 19.

Computational Neuroimaging Group, Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.

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http://dx.doi.org/10.3389/fneur.2019.00229DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433752PMC
March 2019

Pathological Crying and Laughing in Motor Neuron Disease: Pathobiology, Screening, Intervention.

Front Neurol 2019 21;10:260. Epub 2019 Mar 21.

Computational Neuroimaging Group, Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.

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https://www.frontiersin.org/article/10.3389/fneur.2019.00260
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http://dx.doi.org/10.3389/fneur.2019.00260DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438102PMC
March 2019

Neurophysiological markers of network dysfunction in neurodegenerative diseases.

Neuroimage Clin 2019 2;22:101706. Epub 2019 Feb 2.

Academic Unit of Neurology, Trinity Biomedical Sciences Institute, 152-160 Pearse St., Trinity College Dublin, The University of Dublin, Ireland. Electronic address:

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http://dx.doi.org/10.1016/j.nicl.2019.101706DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370863PMC
February 2019

Characteristic Increases in EEG Connectivity Correlate With Changes of Structural MRI in Amyotrophic Lateral Sclerosis.

Cereb Cortex 2019 01;29(1):27-41

Academic Unit of Neurology, Trinity Biomedical Sciences Institute, Trinity College Dublin, the University of Dublin, 152-160 Pearse Street, Dublin, Ireland.

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http://dx.doi.org/10.1093/cercor/bhx301DOI Listing
January 2019

Association between alcohol exposure and the risk of amyotrophic lateral sclerosis in the Euro-MOTOR study.

J Neurol Neurosurg Psychiatry 2019 01 3;90(1):11-19. Epub 2018 Aug 3.

'Rita Levi Montalcini' Department of Neurosciences, University of Turin, Turin, Italy.

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http://dx.doi.org/10.1136/jnnp-2018-318559DOI Listing
January 2019

Connectivity-based characterisation of subcortical grey matter pathology in frontotemporal dementia and ALS: a multimodal neuroimaging study.

Brain Imaging Behav 2018 Dec;12(6):1696-1707

Quantitative Neuroimaging Group, Academic Unit of Neurology, Biomedical Sciences Institute, Trinity College Dublin, Pearse Street, Dublin, Ireland.

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http://dx.doi.org/10.1007/s11682-018-9837-9DOI Listing
December 2018

Global burden of motor neuron diseases: mind the gaps.

Authors:
Orla Hardiman

Lancet Neurol 2018 12 5;17(12):1030-1031. Epub 2018 Nov 5.

Academic Unit of Neurology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland. Electronic address:

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http://dx.doi.org/10.1016/S1474-4422(18)30398-3DOI Listing
December 2018

ALS-specific cognitive and behavior changes associated with advancing disease stage in ALS.

Neurology 2018 10 12;91(15):e1370-e1380. Epub 2018 Sep 12.

From Human Cognitive Neuroscience (C.C., J.N., T.B., R.R., S.A.), Psychology, Philosophy, Psychology and Language Sciences, Euan MacDonald Centre for Motor Neurone Disease Research (C.C., S.A.), and Alzheimer Scotland Dementia Research Centre (R.R.), University of Edinburgh; Anne Rowling Regenerative Neurology Clinic (J.N., S.C., S.P., R.R., L.S., R.S., S.A.), Royal Infirmary of Edinburgh, UK; Academic Unit of Neurology (K.L., M.H., I.M., M.P.-G., A.V., O.H.), Trinity College Dublin; Departments of Psychology (K.L., I.M., N.P., M.P.-G.) and Neurology (O.H.), Beaumont Hospital, Dublin, Ireland; and Maurice Wohl Clinical Neuroscience Institute (T.C., C.E.S., A.A.-C.), Department of Basic and Clinical Neuroscience, King's College London, UK.

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http://dx.doi.org/10.1212/WNL.0000000000006317DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6177274PMC
October 2018

Respiratory measures in amyotrophic lateral sclerosis.

Amyotroph Lateral Scler Frontotemporal Degener 2018 08 23;19(5-6):321-330. Epub 2018 Mar 23.

f Eleanor and Lou Gehrig ALS Center, The Neurological Institute, Columbia University , New York , NY , USA.

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http://dx.doi.org/10.1080/21678421.2018.1452945DOI Listing
August 2018

Understanding the use of NIV in ALS: results of an international ALS specialist survey.

Amyotroph Lateral Scler Frontotemporal Degener 2018 08 16;19(5-6):331-341. Epub 2018 Apr 16.

k Department of Neurology, Brain Centre Rudolf Magnus , University Medical Centre Utrecht , Utrecht , The Netherlands.

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http://dx.doi.org/10.1080/21678421.2018.1457058DOI Listing
August 2018

Multicentre, cross-cultural, population-based, case-control study of physical activity as risk factor for amyotrophic lateral sclerosis.

J Neurol Neurosurg Psychiatry 2018 08 23;89(8):797-803. Epub 2018 Apr 23.

Department of Neurology, Brain Centre Rudolf Magnus, University Medical Centre Utrecht, Utrecht, The Netherlands.

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http://dx.doi.org/10.1136/jnnp-2017-317724DOI Listing
August 2018

The life expectancy of Stephen Hawking, according to the ENCALS model.

Lancet Neurol 2018 08 17;17(8):662-663. Epub 2018 Jul 17.

Department of Neurology, Brain Centre Rudolf Magnus, University Medical Centre Utrecht, Utrecht 3584 CX, Netherlands. Electronic address:

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http://dx.doi.org/10.1016/S1474-4422(18)30241-2DOI Listing
August 2018

The multistep hypothesis of ALS revisited: The role of genetic mutations.

Neurology 2018 08 25;91(7):e635-e642. Epub 2018 Jul 25.

From the "Rita Levi Montalcini" Department of Neuroscience (A. Chiò, A. Canosa, C.M., U.M., M.B., M.B., A. Calvo), University of Torino; Institute of Cognitive Sciences and Technologies (A. Chiò), National Research Council, Rome; ALS Center (L.M., E.B.), Department of Neurology, Azienda Ospedaliera Universitaria Maggiore della Carità; Department of Health Sciences (S.D., L.C.), Interdisciplinary Research Center of Autoimmune Diseases, "Amedeo Avogadro" University of Eastern Piedmont, Novara, Italy; Department of Medical Statistics (N.P.), London School of Hygiene and Tropical Medicine, UK; Centre for Public Health Research (N.P.), Massey University Wellington Campus, New Zealand; Department of Neurology and Neurosurgery (J.H.V., L.H.v.d.B.), Brain Center Rudolf Magnus, University Medical Center Utrecht, the Netherlands; Academic Unit of Neurology (R.M., A.V., O.H., J.R.), Trinity Biomedical Sciences Institute, Trinity College Dublin, Ireland; Istituti Clinici Scientifici Maugeri (G.M.), IRCCS Milano, Italy (Gabriele Mora); and King's College London (W.S., A.A.-C.), Institute of Psychiatry, Psychology and Neuroscience, Maurice Wohl Clinical Neuroscience Institute, UK.

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http://dx.doi.org/10.1212/WNL.0000000000005996DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6105040PMC
August 2018

Referral bias in ALS epidemiological studies.

PLoS One 2018 16;13(4):e0195821. Epub 2018 Apr 16.

Laboratorio di Malattie Neurologiche, Dipartimento di Neuroscienze, IRCCS Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0195821PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5901916PMC
July 2018

The Study of Language in the Amyotrophic Lateral Sclerosis - Frontotemporal Spectrum Disorder: a Systematic Review of Findings and New Perspectives.

Neuropsychol Rev 2018 06 28;28(2):251-268. Epub 2018 Apr 28.

Academic Unit of Neurology, Trinity Biomedical Sciences Institute, Trinity College Dublin, 152-160 Pearse Street, Dublin 2, Ireland.

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http://dx.doi.org/10.1007/s11065-018-9375-7DOI Listing
June 2018

Determining the incidence of familiality in ALS: A study of temporal trends in Ireland from 1994 to 2016.

Neurol Genet 2018 Jun 18;4(3):e239. Epub 2018 May 18.

Academic Unit of Neurology (M.R., M.H., N.D., E.M.C., A.V., O.H.), Trinity College; Department of Genetics (M.A.D., R.M.), Trinity College; and Department of Psychology (N.P.), Beaumont Hospital, Dublin, Ireland.

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http://dx.doi.org/10.1212/NXG.0000000000000239DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5961194PMC
June 2018

Longitudinal structural changes in ALS: a three time-point imaging study of white and gray matter degeneration.

Amyotroph Lateral Scler Frontotemporal Degener 2018 05 7;19(3-4):232-241. Epub 2017 Dec 7.

a Quantitative Neuroimaging Group, Academic Unit of Neurology , Biomedical Sciences Institute, Trinity College Dublin , Dublin , Ireland and.

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http://dx.doi.org/10.1080/21678421.2017.1407795DOI Listing
May 2018

Virtual brain biopsies in amyotrophic lateral sclerosis: Diagnostic classification based on in vivo pathological patterns.

Neuroimage Clin 2017 9;15:653-658. Epub 2017 Jun 9.

Quantitative Neuroimaging Group, Academic Unit of Neurology, Biomedical Sciences Institute, Trinity College Dublin, Ireland. Electronic address:

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http://dx.doi.org/10.1016/j.nicl.2017.06.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5479963PMC
April 2018

Genome-wide Analyses Identify KIF5A as a Novel ALS Gene.

Authors:
Aude Nicolas Kevin P Kenna Alan E Renton Nicola Ticozzi Faraz Faghri Ruth Chia Janice A Dominov Brendan J Kenna Mike A Nalls Pamela Keagle Alberto M Rivera Wouter van Rheenen Natalie A Murphy Joke J F A van Vugt Joshua T Geiger Rick A Van der Spek Hannah A Pliner Shankaracharya Bradley N Smith Giuseppe Marangi Simon D Topp Yevgeniya Abramzon Athina Soragia Gkazi John D Eicher Aoife Kenna Gabriele Mora Andrea Calvo Letizia Mazzini Nilo Riva Jessica Mandrioli Claudia Caponnetto Stefania Battistini Paolo Volanti Vincenzo La Bella Francesca L Conforti Giuseppe Borghero Sonia Messina Isabella L Simone Francesca Trojsi Fabrizio Salvi Francesco O Logullo Sandra D'Alfonso Lucia Corrado Margherita Capasso Luigi Ferrucci Cristiane de Araujo Martins Moreno Sitharthan Kamalakaran David B Goldstein Aaron D Gitler Tim Harris Richard M Myers Hemali Phatnani Rajeeva Lochan Musunuri Uday Shankar Evani Avinash Abhyankar Michael C Zody Julia Kaye Steven Finkbeiner Stacia K Wyman Alex LeNail Leandro Lima Ernest Fraenkel Clive N Svendsen Leslie M Thompson Jennifer E Van Eyk James D Berry Timothy M Miller Stephen J Kolb Merit Cudkowicz Emily Baxi Michael Benatar J Paul Taylor Evadnie Rampersaud Gang Wu Joanne Wuu Giuseppe Lauria Federico Verde Isabella Fogh Cinzia Tiloca Giacomo P Comi Gianni Sorarù Cristina Cereda Philippe Corcia Hannu Laaksovirta Liisa Myllykangas Lilja Jansson Miko Valori John Ealing Hisham Hamdalla Sara Rollinson Stuart Pickering-Brown Richard W Orrell Katie C Sidle Andrea Malaspina John Hardy Andrew B Singleton Janel O Johnson Sampath Arepalli Peter C Sapp Diane McKenna-Yasek Meraida Polak Seneshaw Asress Safa Al-Sarraj Andrew King Claire Troakes Caroline Vance Jacqueline de Belleroche Frank Baas Anneloor L M A Ten Asbroek José Luis Muñoz-Blanco Dena G Hernandez Jinhui Ding J Raphael Gibbs Sonja W Scholz Mary Kay Floeter Roy H Campbell Francesco Landi Robert Bowser Stefan M Pulst John M Ravits Daniel J L MacGowan Janine Kirby Erik P Pioro Roger Pamphlett James Broach Glenn Gerhard Travis L Dunckley Christopher B Brady Neil W Kowall Juan C Troncoso Isabelle Le Ber Kevin Mouzat Serge Lumbroso Terry D Heiman-Patterson Freya Kamel Ludo Van Den Bosch Robert H Baloh Tim M Strom Thomas Meitinger Aleksey Shatunov Kristel R Van Eijk Mamede de Carvalho Maarten Kooyman Bas Middelkoop Matthieu Moisse Russell L McLaughlin Michael A Van Es Markus Weber Kevin B Boylan Marka Van Blitterswijk Rosa Rademakers Karen E Morrison A Nazli Basak Jesús S Mora Vivian E Drory Pamela J Shaw Martin R Turner Kevin Talbot Orla Hardiman Kelly L Williams Jennifer A Fifita Garth A Nicholson Ian P Blair Guy A Rouleau Jesús Esteban-Pérez Alberto García-Redondo Ammar Al-Chalabi Ekaterina Rogaeva Lorne Zinman Lyle W Ostrow Nicholas J Maragakis Jeffrey D Rothstein Zachary Simmons Johnathan Cooper-Knock Alexis Brice Stephen A Goutman Eva L Feldman Summer B Gibson Franco Taroni Antonia Ratti Cinzia Gellera Philip Van Damme Wim Robberecht Pietro Fratta Mario Sabatelli Christian Lunetta Albert C Ludolph Peter M Andersen Jochen H Weishaupt William Camu John Q Trojanowski Vivianna M Van Deerlin Robert H Brown Leonard H van den Berg Jan H Veldink Matthew B Harms Jonathan D Glass David J Stone Pentti Tienari Vincenzo Silani Adriano Chiò Christopher E Shaw Bryan J Traynor John E Landers

Neuron 2018 03;97(6):1268-1283.e6

Department of Neurology, University of Massachusetts Medical School, Worcester, MA 01605, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2018.02.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5867896PMC
March 2018

ECAS A-B-C: alternate forms of the Edinburgh Cognitive and Behavioural ALS Screen.

Amyotroph Lateral Scler Frontotemporal Degener 2018 02 5;19(1-2):57-64. Epub 2017 Dec 5.

a Department of Psychology , University of Edinburgh , Edinburgh , UK.

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http://dx.doi.org/10.1080/21678421.2017.1407793DOI Listing
February 2018

Insular Celtic population structure and genomic footprints of migration.

PLoS Genet 2018 01 25;14(1):e1007152. Epub 2018 Jan 25.

Complex Trait Genomics Laboratory, Smurfit Institute of Genetics, School of Genetics and Microbiology, Trinity College Dublin, College Green, Dublin, Republic of Ireland.

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http://dx.doi.org/10.1371/journal.pgen.1007152DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5784891PMC
January 2018

Needs of informal caregivers across the caregiving course in amyotrophic lateral sclerosis: a qualitative analysis.

BMJ Open 2018 01 27;8(1):e018721. Epub 2018 Jan 27.

Academic Unit of Neurology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.

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http://dx.doi.org/10.1136/bmjopen-2017-018721DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5829772PMC
January 2018

Genetic screening in sporadic ALS and FTD.

J Neurol Neurosurg Psychiatry 2017 12 22;88(12):1042-1044. Epub 2017 Jun 22.

Nuffield Department of Clinical Neurosciences, Oxford University, Oxford, UK.

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http://dx.doi.org/10.1136/jnnp-2017-315995DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5740553PMC
December 2017

Amyotrophic lateral sclerosis.

Lancet 2017 Nov 25;390(10107):2084-2098. Epub 2017 May 25.

Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/S0140-6736(17)31287-4DOI Listing
November 2017

Neuroimaging patterns along the ALS-FTD spectrum: a multiparametric imaging study.

Amyotroph Lateral Scler Frontotemporal Degener 2017 11 31;18(7-8):611-623. Epub 2017 May 31.

a Quantitative Neuroimaging Group, Academic Unit of Neurology , Biomedical Sciences Institute, Trinity College Dublin , Dublin , Ireland.

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http://dx.doi.org/10.1080/21678421.2017.1332077DOI Listing
November 2017

A mapping review of international guidance on the management and care of amyotrophic lateral sclerosis (ALS).

Amyotroph Lateral Scler Frontotemporal Degener 2016 Jul-Aug;17(5-6):325-36. Epub 2016 Apr 14.

m Walter Sermeus, KU Leuven Institute for Healthcare Policy, Department of Public Health and Primary Care , University of Leuven - KU Leuven , Leuven , Belgium.

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http://dx.doi.org/10.3109/21678421.2016.1167911DOI Listing
October 2017

The selective anatomical vulnerability of ALS: 'disease-defining' and 'disease-defying' brain regions.

Amyotroph Lateral Scler Frontotemporal Degener 2016 Oct - Nov;17(7-8):561-570. Epub 2016 Apr 18.

a Quantitative Neuroimaging Group, Academic Unit of Neurology , Biomedical Sciences Institute, Trinity College Dublin , Ireland.

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http://dx.doi.org/10.3109/21678421.2016.1173702DOI Listing
October 2017

Survival analysis of geospatial factors in the Irish ALS cohort.

Amyotroph Lateral Scler Frontotemporal Degener 2016 Oct - Nov;17(7-8):555-560. Epub 2016 May 4.

a Academic Unit of Neurology , Trinity Biomedical Sciences Institute, Trinity College Dublin.

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http://dx.doi.org/10.1080/21678421.2016.1179326DOI Listing
October 2017

Discordant performance on the 'Reading the Mind in the Eyes' Test, based on disease onset in amyotrophic lateral sclerosis.

Amyotroph Lateral Scler Frontotemporal Degener 2016 Oct - Nov;17(7-8):467-472. Epub 2016 May 6.

a Departments of Psychology , Trinity College , Dublin.

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http://dx.doi.org/10.1080/21678421.2016.1177088DOI Listing
October 2017

The beginning of precision medicine in ALS? Treatment to fit the genes.

Neurology 2017 10 4;89(18):1850-1851. Epub 2017 Oct 4.

From the Tel Aviv University Sackler School of Medicine and Yitzhak Shamir (Assaf Harofeh) Medical Center (C.A.), Israel; and Academic Unit of Neurology (O.H.), Trinity Biomedical Sciences Institute, Trinity College, Dublin, Ireland.

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http://dx.doi.org/10.1212/WNL.0000000000004612DOI Listing
October 2017

Amyotrophic lateral sclerosis.

Nat Rev Dis Primers 2017 Oct 5;3:17071. Epub 2017 Oct 5.

Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands.

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http://dx.doi.org/10.1038/nrdp.2017.71DOI Listing
October 2017

A case-control study of hormonal exposures as etiologic factors for ALS in women: Euro-MOTOR.

Neurology 2017 Sep 23;89(12):1283-1290. Epub 2017 Aug 23.

From the Academic Unit of Neurology (J.P.K.R., O.H.), Trinity Biomedical Sciences Institute, Trinity College Dublin, Ireland; Department of Neurology and Neurosurgery (A.E.V., J.H.V., L.H.v.d.B.), Brain Center Rudolf Magnus, University Medical Center Utrecht, the Netherlands; Department of Neuroscience (F.D., A.C.), ALS Centre, University of Torino, Turin, Italy; Institute for Risk Assessment Sciences (R.V.), Department of Environmental Epidemiology, University of Utrecht, the Netherlands; Department of Neurosciences (E.B.), IRCSS, Mario Negri Institute of Pharmacological Research, Milan; and Department of Neuroscience (G.L.), University of Bari, Italy.

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http://dx.doi.org/10.1212/WNL.0000000000004390DOI Listing
September 2017

Critical issues in ALS case-control studies: the case of the Euro-MOTOR study.

Amyotroph Lateral Scler Frontotemporal Degener 2017 08 10;18(5-6):411-418. Epub 2017 Feb 10.

f Neurological Diseases Laboratory, Department of Neurosciences , IRCCS Mario Negri , Milano , Italy.

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http://dx.doi.org/10.1080/21678421.2017.1285939DOI Listing
August 2017

Cerebral venous sinus thrombosis in homocystinuria: Dietary intervention in conjunction with anticoagulation.

SAGE Open Med Case Rep 2017 1;5:2050313X17722289. Epub 2017 Aug 1.

Department of Neurology, Beaumont Hospital, Dublin, UK.

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http://dx.doi.org/10.1177/2050313X17722289DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5542071PMC
August 2017

The changing picture of amyotrophic lateral sclerosis: lessons from European registers.

J Neurol Neurosurg Psychiatry 2017 07 11;88(7):557-563. Epub 2017 Mar 11.

Academic Unit of Neurology, Trinity Biomedical Sciences Institute, Trinity College, Dublin, Ireland.

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http://dx.doi.org/10.1136/jnnp-2016-314495DOI Listing
July 2017

Edaravone: a new treatment for ALS on the horizon?

Lancet Neurol 2017 07 15;16(7):490-491. Epub 2017 May 15.

University Medical Center Utrecht, Netherlands.

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http://dx.doi.org/10.1016/S1474-4422(17)30163-1DOI Listing
July 2017

Assessing behavioural changes in ALS: cross-validation of ALS-specific measures.

J Neurol 2017 Jul 9;264(7):1397-1401. Epub 2017 Jun 9.

Academic Unit of Neurology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland.

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http://dx.doi.org/10.1007/s00415-017-8536-6DOI Listing
July 2017

Benefits, pitfalls, and future design of population-based registers in neurodegenerative disease.

Neurology 2017 Jun 17;88(24):2321-2329. Epub 2017 May 17.

From the Academic Unit of Neurology (J.P.K.R., K.T., O.H.), Trinity Biomedical Sciences Institute, Trinity College Dublin, Ireland; Department of Public Health and Primary Care (C.B.), School of Clinical Medicine, University of Cambridge, UK; Department of Basic Medical Sciences, Neuroscience and Sense Organs (G.L.), University of Bari "Aldo Moro," Bari; Unit of Neurodegenerative Diseases (G.L.), Department of Clinical Research in Neurology, University of Bari "Aldo Moro," Pia Fondazione Cardinale G. Panico, Tricase, Lecce, Italy; Department of Epidemiology and Biostatistics (M.M.G.), University of California, San Francisco; and Department of Neurology (O.H.), Beaumont Hospital, Dublin, Ireland.

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http://dx.doi.org/10.1212/WNL.0000000000004038DOI Listing
June 2017

Amyotrophic lateral sclerosis patient iPSC-derived astrocytes impair autophagy via non-cell autonomous mechanisms.

Mol Brain 2017 06 13;10(1):22. Epub 2017 Jun 13.

Regenerative Medicine Institute (REMEDI), School of Medicine, National University of Ireland Galway, Galway, Ireland.

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http://dx.doi.org/10.1186/s13041-017-0300-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5470320PMC
June 2017

What does the ALSFRS-R really measure? A longitudinal and survival analysis of functional dimension subscores in amyotrophic lateral sclerosis.

J Neurol Neurosurg Psychiatry 2017 05 25;88(5):381-385. Epub 2016 Nov 25.

Academic Unit of Neurology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.

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http://dx.doi.org/10.1136/jnnp-2016-314661DOI Listing
May 2017

Visual encoding, consolidation, and retrieval in amyotrophic lateral sclerosis: executive function as a mediator, and predictor of performance.

Amyotroph Lateral Scler Frontotemporal Degener 2017 05 13;18(3-4):193-201. Epub 2017 Jan 13.

a Department of Psychology , Beaumont Hospital , Dublin , Ireland.

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http://dx.doi.org/10.1080/21678421.2016.1272615DOI Listing
May 2017

Caregivers of patients with amyotrophic lateral sclerosis: investigating quality of life, caregiver burden, service engagement, and patient survival.

J Neurol 2017 May 9;264(5):898-904. Epub 2017 Mar 9.

Department of Psychology, Lower Ground Floor, Beaumont Hospital, Beaumont Road, Dublin 9, Ireland.

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http://dx.doi.org/10.1007/s00415-017-8448-5DOI Listing
May 2017

Survival prediction in Amyotrophic lateral sclerosis based on MRI measures and clinical characteristics.

BMC Neurol 2017 Apr 17;17(1):73. Epub 2017 Apr 17.

Quantitative Neuroimaging Group, Academic Unit of Neurology, Room 5.43, Biomedical Sciences Institute, Trinity College Dublin, Pearse Street, Dublin 2, Ireland.

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http://bmcneurol.biomedcentral.com/articles/10.1186/s12883-0
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http://dx.doi.org/10.1186/s12883-017-0854-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5393027PMC
April 2017

A genetic overview of Atlantic coastal populations from Europe and North-West Africa based on a 17 X-STR panel.

Forensic Sci Int Genet 2017 03 30;27:167-171. Epub 2016 Nov 30.

BIOMICs Research Group, Lascaray Research Center, University of the Basque Country UPV/EHU. Avda. Miguel de Unamuno, 3, 01006 Vitoria-Gasteiz, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.fsigen.2016.11.011DOI Listing
March 2017

Genetic testing in ALS: A survey of current practices.

Neurology 2017 Mar 3;88(10):991-999. Epub 2017 Feb 3.

From the Academic Unit of Neurology (A.V., R.L.M., M.H., O.T., O.H.), Trinity College Dublin; Cognitive Aging and Epidemiology Centre (S.A.), University of Edinburgh; and Institute of Psychiatry, Psychology and Neuroscience (A.A.-C.), King's College London, UK.

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http://dx.doi.org/10.1212/WNL.0000000000003686DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5333513PMC
March 2017

From first symptoms to diagnosis of amyotrophic lateral sclerosis: perspectives of an Irish informal caregiver cohort-a thematic analysis.

BMJ Open 2017 03 20;7(3):e014985. Epub 2017 Mar 20.

Academic Unit of Neurology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland.

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http://dx.doi.org/10.1136/bmjopen-2016-014985DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5372020PMC
March 2017

Genetic correlation between amyotrophic lateral sclerosis and schizophrenia.

Nat Commun 2017 03 21;8:14774. Epub 2017 Mar 21.

Department of Neurology and Neurosurgery, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht 3584 CX, The Netherlands.

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http://dx.doi.org/10.1038/ncomms14774DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5364411PMC
March 2017

Identifying behavioural changes in ALS: Validation of the Beaumont Behavioural Inventory (BBI).

Amyotroph Lateral Scler Frontotemporal Degener 2017 Feb 28;18(1-2):68-73. Epub 2016 Nov 28.

a Academic Unit of Neurology, Trinity Biomedical Sciences Institute , Trinity College Dublin , Ireland.

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http://dx.doi.org/10.1080/21678421.2016.1248976DOI Listing
February 2017

Screening for cognitive dysfunction in ALS: validation of the Edinburgh Cognitive and Behavioural ALS Screen (ECAS) using age and education adjusted normative data.

Amyotroph Lateral Scler Frontotemporal Degener 2017 Feb 28;18(1-2):99-106. Epub 2016 Nov 28.

a Academic Unit of Neurology , Trinity Biomedical Sciences Institute, Trinity College Dublin , Ireland.

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http://dx.doi.org/10.1080/21678421.2016.1249887DOI Listing
February 2017

A population-based epidemiologic study of adult neuromuscular disease in the Republic of Ireland.

Neurology 2017 Jan 7;88(3):304-313. Epub 2016 Dec 7.

From the Department of Neurology (S.L., A.M.R.), Cork University Hospital; and Department of Neurology (O.H.), Beaumont Hospital, Dublin, Ireland.

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http://www.neurology.org/lookup/doi/10.1212/WNL.000000000000
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http://dx.doi.org/10.1212/WNL.0000000000003504DOI Listing
January 2017

Age-period-cohort analysis of trends in amyotrophic lateral sclerosis incidence.

J Neurol 2016 Oct 2;263(10):1919-26. Epub 2016 Jul 2.

Academic Unit of Neurology, School of Medicine, Trinity College Dublin, TBSI, 152-160 Pearse Street, Dublin 2, Ireland.

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http://dx.doi.org/10.1007/s00415-016-8215-zDOI Listing
October 2016

Amyotrophic lateral sclerosis: moving towards a new classification system.

Lancet Neurol 2016 10;15(11):1182-94

Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Netherlands.

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http://dx.doi.org/10.1016/S1474-4422(16)30199-5DOI Listing
October 2016

NEK1 variants confer susceptibility to amyotrophic lateral sclerosis.

Nat Genet 2016 09 25;48(9):1037-42. Epub 2016 Jul 25.

Department of Neurology, University of Massachusetts Medical School, Worcester, Massachusetts, USA.

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http://dx.doi.org/10.1038/ng.3626DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5560030PMC
September 2016

Genome-wide association analyses identify new risk variants and the genetic architecture of amyotrophic lateral sclerosis.

Authors:
Wouter van Rheenen Aleksey Shatunov Annelot M Dekker Russell L McLaughlin Frank P Diekstra Sara L Pulit Rick A A van der Spek Urmo Võsa Simone de Jong Matthew R Robinson Jian Yang Isabella Fogh Perry Tc van Doormaal Gijs H P Tazelaar Max Koppers Anna M Blokhuis William Sproviero Ashley R Jones Kevin P Kenna Kristel R van Eijk Oliver Harschnitz Raymond D Schellevis William J Brands Jelena Medic Androniki Menelaou Alice Vajda Nicola Ticozzi Kuang Lin Boris Rogelj Katarina Vrabec Metka Ravnik-Glavač Blaž Koritnik Janez Zidar Lea Leonardis Leja Dolenc Grošelj Stéphanie Millecamps François Salachas Vincent Meininger Mamede de Carvalho Susana Pinto Jesus S Mora Ricardo Rojas-García Meraida Polak Siddharthan Chandran Shuna Colville Robert Swingler Karen E Morrison Pamela J Shaw John Hardy Richard W Orrell Alan Pittman Katie Sidle Pietro Fratta Andrea Malaspina Simon Topp Susanne Petri Susanne Abdulla Carsten Drepper Michael Sendtner Thomas Meyer Roel A Ophoff Kim A Staats Martina Wiedau-Pazos Catherine Lomen-Hoerth Vivianna M Van Deerlin John Q Trojanowski Lauren Elman Leo McCluskey A Nazli Basak Ceren Tunca Hamid Hamzeiy Yesim Parman Thomas Meitinger Peter Lichtner Milena Radivojkov-Blagojevic Christian R Andres Cindy Maurel Gilbert Bensimon Bernhard Landwehrmeyer Alexis Brice Christine A M Payan Safaa Saker-Delye Alexandra Dürr Nicholas W Wood Lukas Tittmann Wolfgang Lieb Andre Franke Marcella Rietschel Sven Cichon Markus M Nöthen Philippe Amouyel Christophe Tzourio Jean-François Dartigues Andre G Uitterlinden Fernando Rivadeneira Karol Estrada Albert Hofman Charles Curtis Hylke M Blauw Anneke J van der Kooi Marianne de Visser An Goris Markus Weber Christopher E Shaw Bradley N Smith Orietta Pansarasa Cristina Cereda Roberto Del Bo Giacomo P Comi Sandra D'Alfonso Cinzia Bertolin Gianni Sorarù Letizia Mazzini Viviana Pensato Cinzia Gellera Cinzia Tiloca Antonia Ratti Andrea Calvo Cristina Moglia Maura Brunetti Simona Arcuti Rosa Capozzo Chiara Zecca Christian Lunetta Silvana Penco Nilo Riva Alessandro Padovani Massimiliano Filosto Bernard Muller Robbert Jan Stuit Ian Blair Katharine Zhang Emily P McCann Jennifer A Fifita Garth A Nicholson Dominic B Rowe Roger Pamphlett Matthew C Kiernan Julian Grosskreutz Otto W Witte Thomas Ringer Tino Prell Beatrice Stubendorff Ingo Kurth Christian A Hübner P Nigel Leigh Federico Casale Adriano Chio Ettore Beghi Elisabetta Pupillo Rosanna Tortelli Giancarlo Logroscino John Powell Albert C Ludolph Jochen H Weishaupt Wim Robberecht Philip Van Damme Lude Franke Tune H Pers Robert H Brown Jonathan D Glass John E Landers Orla Hardiman Peter M Andersen Philippe Corcia Patrick Vourc'h Vincenzo Silani Naomi R Wray Peter M Visscher Paul I W de Bakker Michael A van Es R Jeroen Pasterkamp Cathryn M Lewis Gerome Breen Ammar Al-Chalabi Leonard H van den Berg Jan H Veldink

Nat Genet 2016 09 25;48(9):1043-8. Epub 2016 Jul 25.

Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, the Netherlands.

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http://dx.doi.org/10.1038/ng.3622DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5556360PMC
September 2016

Caregiving in ALS - a mixed methods approach to the study of Burden.

BMC Palliat Care 2016 Sep 5;15(1):81. Epub 2016 Sep 5.

Academic Unit of Neurology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland.

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http://dx.doi.org/10.1186/s12904-016-0153-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5011853PMC
September 2016

CCNF mutations in amyotrophic lateral sclerosis and frontotemporal dementia.

Nat Commun 2016 Apr 15;7:11253. Epub 2016 Apr 15.

Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, New South Wales 2109, Australia.

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http://dx.doi.org/10.1038/ncomms11253DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4835537PMC
April 2016