Publications by authors named "Orkun Sarioglu"

11 Publications

  • Page 1 of 1

Clot-based radiomics features predict first pass effect in acute ischemic stroke.

Interv Neuroradiol 2021 May 18:15910199211019176. Epub 2021 May 18.

Department of Radiology, Health Sciences University, Tepecik Educational and Research Hospital, Izmir, Turkey.

Purpose: Our aim was to evaluate the performance of clot-based radiomics features (RFs) for predicting first pass effect (FPE) in patients with acute ischemic stroke (AIS). The secondary purpose was to search for any other variables associated with FPE.

Materials And Methods: Patients who underwent mechanical thrombectomy (MT) for anterior circulation large vessel stroke in a single center were retrospectively reviewed. Patients were divided into two groups: FPE and non-FPE. Two observers extracted RFs from the clot on pretreatment noncontrast computed tomography (NCCT) images. Demographic, clinical, periprocedural, and RFs were compared between the groups and receiver operating characteristic (ROC) curves were constructed. Logistic regression analysis was used to determine the independent predictors of FPE.

Results: Fifty-two patients (27 female, 25 male; mean age 64.50 ± 15.15) who were treated by stent retrievers as the first option were included in the study. FPE was achieved in 25 patients (25/52, 48.1%). Twelve RFs were significantly different between patients with FPE and non-FPE. The long-run low gray-level emphasis (odds ratio = 44.24, p = 0.003) and the zone percentage (odds ratio = 16.88, p = 0.017) were found as independent predictors of FPE. Female sex and a baseline ASPECT score of >8.5 were the other independent variables to predict FPE. The diagnostic accuracy to predict FPE was observed as 83% when using all independent predictors in our predictive model.

Conclusions: Clot-based RFs on NCCT may help to estimate the success of the intended outcome of MT in patients with AIS.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1177/15910199211019176DOI Listing
May 2021

The role of CT texture analysis in predicting the clinical outcomes of acute ischemic stroke patients undergoing mechanical thrombectomy.

Eur Radiol 2021 Aug 9;31(8):6105-6115. Epub 2021 Feb 9.

Department of Radiology, Health Sciences University, Tepecik Educational and Research Hospital, 35180 Yenisehir, Konak, Izmir, Turkey.

Objectives: To evaluate the performance of CT-based texture analysis (TA) for predicting clinical outcomes of mechanical thrombectomy (MT) in acute ischemic stroke (AIS).

Methods: This single-center, retrospective study contained 64 consecutive patients with AIS who underwent MT for large anterior circulation occlusion between December 2016 and January 2020. Patients were divided into 2 groups according to the modified Rankin scale (mRS) scores at 3 months as good outcome (mRS ≤ 2) and bad outcome (mRS > 2). Two observers examined the early ischemic changes for TA on baseline non-contrast CT images independently. Demographic, clinical, periprocedural, and texture variables were compared between the groups and ROC curves were made. Logistic regression analysis was used and a model was created to determine the independent predictors of a bad outcome.

Results: Sixty-four patients (32 female, 32 male; mean age 63.03 ± 14.42) were included in the study. Fourteen texture parameters were significantly different between patients with good and bad outcomes. The long-run high gray-level emphasis (LRHGE), which is a gray-level run-length matrix (GLRLM) feature, showed the highest sensitivity (80%) and specificity (70%) rates to predict disability. The GLRLM_LRHGE value of > 4885.0 and the time from onset to puncture of > 237.5 mi were found as independent predictors of the bad outcome. The diagnostic rate was 80.0% when using the combination of the GLRLM_LRHGE and the time from onset to puncture cutoff values.

Conclusion: CT-based TA might be a promising modality to predict clinical outcome after MT in patients with AIS.

Key Points: • The gray-level run-length matrix parameters displayed higher diagnostic performance among the texture features. • The long-run high gray-level emphasis showed the highest sensitivity and specificity rates for predicting a bad outcome in stroke patients undergoing mechanical thrombectomy. • The gray-level run-length matrix_long-run high gray-level emphasis value of > 4885.0 (OR = 11.06; 95% CI = 2.51 - 48.77; p = 0.001) and the time from onset to puncture of > 237.5 min (OR = 8.55; 95% CI = 1.96 - 37.21; p = 0.004) were found as independent predictors of the bad outcome.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00330-021-07720-4DOI Listing
August 2021

Relationship between the first pass effect and the platelet-lymphocyte ratio in acute ischemic stroke.

Interv Neuroradiol 2020 Nov 25:1591019920976251. Epub 2020 Nov 25.

Department of Radiology, Health Sciences University, Tepecik Educational and Research Hospital, Izmir, Turkey.

Purpose: The aim of this study was to evaluate the relationship between platelet-lymphocyte ratio (PLR) and first pass effect (FPE) in patients with acute ischemic stroke (AIS). Our secondary goal was to investigate other laboratory, demographic or technical parameters that may be related to FPE and to search for independent predictors of FPE.

Materials And Methods: Patients who underwent mechanical thrombectomy (MT) in our hospital between January 2017 and February 2020 were reviewed. Patients were divided into two groups: FPE and non-FPE. Demographic features, laboratory parameters, pretreatment imaging and clinical features, angiographic and clinical outcomes were recorded and compared between the two groups. Logistic regression analysis was performed to analyze the independent predictors and a predictive model was produced for demonstrating the possibility to achieve FPE.

Results: The study consisted of 83 patients (37 female, 46 male; mean age 62.69 ± 15.16) who were treated by MT. FPE was achieved in 32 patients (32/83, 38.6%). PLR was higher in the non-FPE group (195.35 ± 101.49) when compared to the FPE group (103.17 ± 37.06). A PLR value of <126.3 and female sex were found as independent predictors of FPE. Our predictive model estimated the chance of FPE as 77.9% in female patients who had PLR values lower than 126.3 while it was 77.1% when only using the PLR cutoff value.

Conclusions: High levels of PLR were associated with the failure of FPE. High values of PLR may be considered as a negative predictor for FPE achievement prior to MT in patients with AIS.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1177/1591019920976251DOI Listing
November 2020

Neuroimaging and calvarial findings in achondroplasia.

Pediatr Radiol 2020 11 2;50(12):1669-1679. Epub 2020 Nov 2.

Department of Radiology, Division of Pediatric Radiology, Dokuz Eylul University School of Medicine, 35340, Balcova, Izmir, Turkey.

Achondroplasia is the most common hereditary form of dwarfism and is characterized by short stature, macrocephaly and various skeletal abnormalities. The phenotypic changes are mainly related to the inhibition of endochondral bone growth. Besides the several commonly known physical features that are characteristic of this syndrome, achondroplasia can affect the central nervous system. The impact on the central nervous system can cause some important clinical conditions. Thus, awareness of detailed neuroimaging features is helpful for the follow-up and management of complications. Although the neuroimaging findings in children with achondroplasia have been noted recently, no literature has specifically reviewed these findings extensively. Radiologists should be familiar of these findings because they have an important role in the diagnosis of achondroplasia and the recognition of complications. The aim of this pictorial essay is to review and systematize the distinctive characteristics and abnormalities of the central nervous system and the calvarium in children with achondroplasia.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00247-020-04841-8DOI Listing
November 2020

Angiographic Findings and Outcomes of Bronchial Artery Embolization in Patients with Pulmonary Tuberculosis.

Eurasian J Med 2020 Jun 2;52(2):126-131. Epub 2020 Jun 2.

Department of Radiology, Health Sciences University, Tepecik Educational and Research Hospital, Izmir, Turkey.

Objective: We aimed to evaluate the angiographic findings and outcomes of bronchial artery embolization in tuberculosis patients and to compare them with those of non-tuberculosis patients.

Materials And Methods: Patients who underwent bronchial artery embolization in a single interventional radiology department with hemoptysis were reviewed. A total of 89 patients (66 males and 23 females; mean age 52.71±15.37) were incorporated in the study. The patients were divided into two groups: tuberculosis group (n=36) and non-tuberculosis group (16 malignancy, 22 bronchiectasis, 6 pulmonary infection, 5 chronic obstructive pulmonary disease, 4 idiopathic; n=53). Angiography and embolization procedure were performed by interventional radiologists with 5, 10, and 20 years of experience. Angiographic findings were classified as tortuosity, hypertrophy, hypervascularity, aneurysm, bronchopulmonary shunt, extravasation, and normal bronchial artery. Chi-square test was used to compare angiographic findings between tuberculosis and non-tuberculosis patient groups.

Results: Bronchopulmonary shunt was found to be significantly higher in the tuberculosis group as compared to that in the non-tuberculosis group (p=0.002). Neither of the groups showed a statistically significant difference with respect to recurrence (p=0.436).

Conclusion: Bronchial artery embolization is a useful and effective treatment method of hemoptysis in tuberculosis. Evaluation of bronchopulmonary shunts in patients with tuberculosis is critical for the reduction of catastrophic complications.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.5152/eurasianjmed.2020.19221DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311123PMC
June 2020

MRI-based texture analysis for differentiating pediatric craniofacial rhabdomyosarcoma from infantile hemangioma.

Eur Radiol 2020 Oct 8;30(10):5227-5236. Epub 2020 May 8.

Division of Pediatric Hematology and Oncology, Department of Pediatrics, Dokuz Eylul University School of Medicine, Izmir, Turkey.

Objectives: To evaluate the diagnostic performance of MRI texture analysis (TA) for differentiation of pediatric craniofacial rhabdomyosarcoma (RMS) from infantile hemangioma (IH).

Methods: This study included 15 patients with RMS and 42 patients with IH who underwent MRI before an invasive procedure. All patients had a solitary lesion. T2-weighted and fat-suppressed contrast-enhanced T1-weighted axial images were used for TA. Two readers delineated the tumor borders for TA independently and evaluated the qualitative MRI characteristics in consensus. The differences of the texture features' values between the groups were assessed and ROC curves were calculated. Logistic regression analysis was used to analyze the value of TA with and without the combination of the qualitative MRI characteristics. A p value < 0.05 was considered statistically significant.

Results: Thirty-eight texture features were calculated for each tumor. Eighteen features on T2-weighted images and 25 features on contrast-enhanced T1-weighted images were significantly different between the RMSs and IHs. On contrast-enhanced T1-weighted images, the short-zone emphasis (SZE), which was a gray-level zone length matrix (GLZLM) parameter, had the largest area under the curve: 0.899 (sensitivity 93%, specificity 87%). The independent predictor for the RMS among the qualitative MRI characteristics was heterogeneous contrast enhancement (p < 0.001). Using only a GLZLM_SZE value of lower than 0.72 was found to be the best diagnostic parameter in predicting RMS (p < 0.001; 95% CI, 8.770-992.4).

Conclusion: MRI-based TA may contribute to differentiate RMS from IH without invasive procedures.

Key Points: • Texture analysis may help to distinguish between rhabdomyosarcoma and infantile hemangioma without invasive procedures. • The gray-level zone length matrix parameters, especially the short-zone emphasis, may be a potential predictor for rhabdomyosarcoma. • Using contrast-enhanced T1-weighted images may be superior to T2-weighted images to differentiate rhabdomyosarcoma from infantile hemangioma in texture analysis.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00330-020-06908-4DOI Listing
October 2020

Relationship of arteriovenous fistula stenosis and thrombosis with the platelet-lymphocyte ratio in hemodialysis patients.

J Vasc Access 2020 Sep 30;21(5):630-635. Epub 2019 Dec 30.

Department of Radiology, Izmir University of Health Sciences Tepecik Training and Research Hospital, Izmir, Turkey.

Background: The platelet-lymphocyte ratio, which was reported to have a strong relationship with chronic inflammation and thrombosis, is a useful biomarker. The purpose of this study was to evaluate the relationship between the platelet-lymphocyte ratio, arteriovenous stenosis, and thrombosis in patients with chronic renal failure.

Methods: Patients who were referred to our interventional radiology department due to arteriovenous fistula dysfunction from dialysis units between August 2015 and December 2018 were retrospectively reviewed. In the study, 95 patients with arteriovenous fistula access problems were included. Patients were divided into two groups: stenosis ( = 52) and thrombosis ( = 43). Thirty-six subjects with a patent left radiocephalic arteriovenous fistula proven by both color Doppler ultrasonography and clinically were added to the control group. Blood samples were obtained on the same day before the fistulography.

Results: Platelet counts, lymphocyte counts, and platelet-lymphocyte ratio were found to be significantly different between the three groups. After the Bonferroni post hoc analysis, there was a significant difference between the stenosis and control group ( = 0.017), and the thrombosis and control group ( < 0.001) in terms of the platelet-lymphocyte ratio. No significant difference for any parameter was found between stenosis and thrombosis group.

Conclusion: High levels of the platelet-lymphocyte ratio may be a supportive finding of arteriovenous fistula stenosis and thrombosis and can be taken into consideration during hemodialysis-dependent patients' follow-up.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1177/1129729819894113DOI Listing
September 2020

The effect of anatomic variations and maxillary sinus volume in antrochoanal polyp formation.

Eur Arch Otorhinolaryngol 2020 Apr 17;277(4):1067-1072. Epub 2019 Dec 17.

Otorhinolaryngology Clinic, Univercity of Health Science, Tepecik Training and Research Hospital, İzmir, Turkey.

Purpose: The antrochoanal polyp (ACP), otherwise known as the Killain polyp, is a benign lesion that originates from maxillary sinus mucosa, extending from the accessory ostium towards the middle meatus, and later tends to protrude posteriorly towards the choana and nasopharynx. Many studies have emphasized that its etiopathogenesis is unclear. Research suggests that chronic sinusitis and allergic rhinitis are factors that play an important role in the formation of ACP, as well as anatomical variations. In this study, we aimed to evaluate the effect of anatomical variations and maxillary sinus volume in patients diagnosed with anthrochoanal polyp.

Methods: Paranasal sinus computed tomography (PNS CT) images of patients with unilateral ACP patients were examined. The non-ACP sides of the patients comprised the control group. Nasal septal deviation, agger nasi cells, concha bullosa, paradoxical middle turbinate, hyperpneumotized ethmoid bulla, uncinate pathology (medialized or pneumatized uncinate), haller cell, accessory ostium, maxillary sinus retention cyst and maxillary sinus volumes were evaluated.

Results: The study included a total of 54 patients (33 females, 21 males). Mean patient age was 22.92 ± 13.95 (range 6-56) years. Mean maxillary sinus volume was 17.88 ± 5.16 mm for the ACP sides and 16.37 ± 4.55 mm for the non-ACP sides. Maxillary sinus volume was significantly larger in the ACP side (p = 0.000). Concha bullosa was observed on the ACP side in 23 patients (42.6%) and in the non-ACP side in 21 patients (38.9%). Agger nasi cells were observed in the ACP side in 47 patients (87.0%) and in the non-ACP side in 42 patients (77.7%). Hyperpneumatized ethmoid bulla was observed in the ACP side in 14 patients (25.9%) and in the non-ACP side in 12 patients (22.2%). Haller cells were observed in the ACP side in seven patients (12.96%) and in the non-ACP side in ten patients (18.51%).

Conclusion: Disrupted airflow of the well-developed maxillary sinus cavity due to anatomical variations seems to be an effective factor in the formation of ACP.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00405-019-05762-5DOI Listing
April 2020

Interventional treatment options in pseudoaneurysms: different techniques in different localizations.

Pol J Radiol 2019 23;84:e319-e327. Epub 2019 Aug 23.

Department of Radiology, Health Sciences University, Tepecik Educational and Research Hospital, Izmir, Turkey.

Pseudoaneurysms are commonly experienced vascular abnormalities. The increase in the number of surgical and arteriographic procedures has caused a higher prevalence of pseudoaneurysms. Conventional angiography is still the gold standard method for diagnosis, but other imaging modalities such as duplex Doppler ultrasonography, magnetic resonance angiography and computed tomographic angiography are useful in noninvasive detection. Over the past few years, interventional radiological treatment has evolved and taken the place of surgery in management. There are different kinds of percutaneous and endovascular treatment methods in pseudoaneurysm management. Treatment options depend on certain conditions. We used a case-based approach to discuss pseudoaneurysms and their appropriate treatment by interventional radiological methods in this article.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.5114/pjr.2019.88021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6798774PMC
August 2019

Evaluation of vertebral bone mineral density in scoliosis by using quantitative computed tomography.

Pol J Radiol 2019 25;84:e131-e135. Epub 2019 Feb 25.

Department of Radiology, Dokuz Eylul University Faculty of Medicine, Turkey.

Purpose: Scoliosis is described as a lateral curvature of the spine. We aimed to evaluate bone mineral density (BMD) in patients with scoliosis by using quantitative computed tomography (QCT) and compare the BMD of idiopathic and congenital scoliosis patients.

Material And Methods: Forty-three patients aged 1 to 40 years with idiopathic, congenital, or neuromuscular scoliosis and 41 matched controls of the same sex and approximate age were included in the study. Measurements of BMD were performed by QCT analysis for each vertebral body from T12 to L5, and mean BMD was calculated for each case.

Results: Twenty-two of the patients with scoliosis were idiopathic, 15 were congenital, four were neuromuscular, and two were neurofibromatosis. The mean BMD values of patients with scoliosis were significantly lower compared with the control group (106.8 ± 33.4 mg/cm vs. 124.9 ± 29.1 mg/cm, = 0.009). No significant difference in BMD values was found between idiopathic and congenital scoliosis patients ( > 0.05).

Conclusions: This study illustrated that the vertebral body BMD values of the patients with scoliosis were significantly lower than those seen in the control group.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.5114/pjr.2019.84060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6479145PMC
February 2019

Drug-Eluting Balloon Angioplasty for Juxta-Anastomotic Stenoses in Distal Radiocephalic Hemodialysis Fistulas: Long-Term Patency Results.

Cardiovasc Intervent Radiol 2019 Jun 29;42(6):835-840. Epub 2019 Mar 29.

Department of Radiology, Faculty of Medicine, Dokuz Eylul University, Mithatpasa Cad., Inciralti, 35340, Izmir, Turkey.

Purpose: To evaluate long-term primary and secondary patency results of drug-eluting balloon angioplasty for the treatment of juxta-anastomotic stenoses in distal radiocephalic arteriovenous fistulas.

Materials And Methods: Thirty-eight patients with juxta-anastomotic stenotic distal radiocephalic arteriovenous fistulas who underwent endovascular treatment with drug-eluting balloons between January 2014 and August 2016 in our interventional radiology department were included in this retrospective study. Color Doppler examination for follow-up was performed 15 days, 6 months, 12 months, 18 months, 24 months, 36 months, and 48 months after the procedure. Kaplan-Meier analysis was used to estimate primary and secondary patency rates.

Results: Totally, 42 angioplasty with drug-eluting balloons was performed in 38 patients (20 men and 18 women; mean age 66.42 ± 12.01). Technical and clinical success rate was 100% (42/42). The mean follow-up period was 27.71 months ± 12.98 (range, 1-54 months). The estimated primary patency rates at 6 months were 94.7% (95% CI, 80.9%-99.0%), at 12 months were 81.2% (95% CI, 64.6%-91.4%), at 24 months were 60.7% (95% CI, 43.6%-75.7%), and at 48 months were 53.1% (95% CI, 36.5%-69.1%). The estimated secondary patency rates at 6 months were 97.3% (95% CI, 84.5%-99.8%), at 12 months were 86.5% (95% CI, 70.7%-94.8%), at 24 months were 69.0% (95% CI, 51.8%-82.4%), and at 48 months were 61.7% (95% CI, 44.6%-76.5%).

Conclusion: Drug-eluting balloon angioplasty is a useful, effective technique in dysfunctional radiocephalic fistulas due to juxta-anastomotic stenoses. We demonstrated remarkably high primary patency rates at 6, 12, 24, and 48 months.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00270-019-02213-wDOI Listing
June 2019
-->