Orit Rozenblatt-Rosen

Orit Rozenblatt-Rosen

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Orit Rozenblatt-Rosen

Orit Rozenblatt-Rosen

Publications by authors named "Orit Rozenblatt-Rosen"

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57Publications

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Transcriptional Atlas of Intestinal Immune Cells Reveals that Neuropeptide α-CGRP Modulates Group 2 Innate Lymphoid Cell Responses.

Immunity 2019 Oct;51(4):696-708.e9

Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Molecular Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA; Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA; Center for Microbiome Informatics and Therapeutics, Massachusetts Institute of Technology, Cambridge, MA 02114, USA; Center for Computational and Integrative Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10747613193037
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http://dx.doi.org/10.1016/j.immuni.2019.09.004DOI Listing
October 2019

An Integrative Model of Cellular States, Plasticity, and Genetics for Glioblastoma.

Cell 2019 Aug 18;178(4):835-849.e21. Epub 2019 Jul 18.

Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA; Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2019.06.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6703186PMC
August 2019

A Cellular Taxonomy of the Bone Marrow Stroma in Homeostasis and Leukemia.

Cell 2019 Jun 23;177(7):1915-1932.e16. Epub 2019 May 23.

Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA 02114, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00928674193045
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http://dx.doi.org/10.1016/j.cell.2019.04.040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6570562PMC
June 2019

The Pediatric Cell Atlas: Defining the Growth Phase of Human Development at Single-Cell Resolution.

Dev Cell 2019 Apr 28;49(1):10-29. Epub 2019 Mar 28.

Department of Biomedical Informatics, University of Cincinnati College of Medicine, and Cincinnati Children's Hospital Medical Center, Division of Biomedical Informatics, Cincinnati, OH 45229, USA.

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http://dx.doi.org/10.1016/j.devcel.2019.03.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6616346PMC
April 2019

Lineage Tracing in Humans Enabled by Mitochondrial Mutations and Single-Cell Genomics.

Cell 2019 Mar 28;176(6):1325-1339.e22. Epub 2019 Feb 28.

Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Division of Hematology/Oncology, Boston Children's Hospital and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00928674193005
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http://dx.doi.org/10.1016/j.cell.2019.01.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408267PMC
March 2019

Checkpoint Blockade Immunotherapy Induces Dynamic Changes in PD-1CD8 Tumor-Infiltrating T Cells.

Immunity 2019 01 8;50(1):181-194.e6. Epub 2019 Jan 8.

Evergrande Center for Immunologic Diseases and Ann Romney Center for Neurologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA 02115, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10747613183052
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http://dx.doi.org/10.1016/j.immuni.2018.11.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336113PMC
January 2019

T Helper Cell Cytokines Modulate Intestinal Stem Cell Renewal and Differentiation.

Cell 2018 11 1;175(5):1307-1320.e22. Epub 2018 Nov 1.

Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Boston, MA 02114, USA; Center for Microbiome informatics and Therapeutics, MIT, Cambridge, MA 02139, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00928674183131
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http://dx.doi.org/10.1016/j.cell.2018.10.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6239889PMC
November 2018

Single-Cell Transcriptomic Analysis of Primary and Metastatic Tumor Ecosystems in Head and Neck Cancer.

Cell 2017 Dec 30;171(7):1611-1624.e24. Epub 2017 Nov 30.

Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00928674173127
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http://dx.doi.org/10.1016/j.cell.2017.10.044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5878932PMC
December 2017

Single-cell transcriptomics to explore the immune system in health and disease.

Science 2017 10;358(6359):58-63

Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.

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http://dx.doi.org/10.1126/science.aan6828DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5654495PMC
October 2017

Core Circadian Clock Genes Regulate Leukemia Stem Cells in AML.

Cell 2016 Apr;165(2):303-16

Department of Medicine, Division of Hematology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; Broad Institute of Harvard University and MIT, Cambridge, MA 02142, USA; Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2016.03.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4826477PMC
April 2016

Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma.

Science 2014 Jun 12;344(6190):1396-401. Epub 2014 Jun 12.

Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA. Broad Institute of Harvard and Massachusetts Institute of Techonology (MIT), Cambridge, MA 02142, USA. Howard Hughes Medical Institute Chevy Chase, MD 20815, USA.

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http://www.sciencemag.org/cgi/doi/10.1126/science.1254257
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http://dx.doi.org/10.1126/science.1254257DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4123637PMC
June 2014

Reconstructing and reprogramming the tumor-propagating potential of glioblastoma stem-like cells.

Cell 2014 Apr 10;157(3):580-94. Epub 2014 Apr 10.

Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2014.02.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4004670PMC
April 2014

Merkel cell polyomavirus large T antigen has growth-promoting and inhibitory activities.

J Virol 2013 Jun 20;87(11):6118-26. Epub 2013 Mar 20.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1128/JVI.00385-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3648111PMC
June 2013

Transcriptional activators enhance polyadenylation of mRNA precursors.

Mol Cell 2011 Feb;41(4):409-18

Department of Biological Sciences, Columbia University, New York, NY 10027, USA.

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http://dx.doi.org/10.1016/j.molcel.2011.01.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3060669PMC
February 2011

The menin tumor suppressor protein is phosphorylated in response to DNA damage.

PLoS One 2011 Jan 14;6(1):e16119. Epub 2011 Jan 14.

Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0016119PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3021530PMC
January 2011

The tumor suppressor Cdc73 functionally associates with CPSF and CstF 3' mRNA processing factors.

Proc Natl Acad Sci U S A 2009 Jan 9;106(3):755-60. Epub 2009 Jan 9.

Department of Medical Oncology, Dana-Farber Cancer Institute, and Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1073/pnas.0812023106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2615665PMC
January 2009

Phosphorylation of the menin tumor suppressor protein on serine 543 and serine 583.

Mol Cancer Res 2006 Oct;4(10):793-801

Department of Medical Oncology, Dana-Farber Cancer Institute, 44 Binney St., Boston, MA 02115, USA.

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http://dx.doi.org/10.1158/1541-7786.MCR-06-0123DOI Listing
October 2006

Menin regulates pancreatic islet growth by promoting histone methylation and expression of genes encoding p27Kip1 and p18INK4c.

Proc Natl Acad Sci U S A 2005 Oct 29;102(41):14659-64. Epub 2005 Sep 29.

Departments of Developmental Biology and Medicine (Oncology Division), Stanford University School of Medicine, Stanford, CA 94305-5329.

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http://dx.doi.org/10.1073/pnas.0503484102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1253549PMC
October 2005

The menin tumor suppressor protein is an essential oncogenic cofactor for MLL-associated leukemogenesis.

Cell 2005 Oct;123(2):207-18

Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA.

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http://dx.doi.org/10.1016/j.cell.2005.09.025DOI Listing
October 2005

Menin and MLL cooperatively regulate expression of cyclin-dependent kinase inhibitors.

Proc Natl Acad Sci U S A 2005 Jan 7;102(3):749-54. Epub 2005 Jan 7.

Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1073/pnas.0408836102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC545577PMC
January 2005

Induction of chondrocyte growth arrest by FGF: transcriptional and cytoskeletal alterations.

J Cell Sci 2002 Feb;115(Pt 3):553-62

Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel.

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February 2002